Exhibit 10.18

                                    Addendum

This Addendum is made the 23rd day of April 2002 by and between:

     (1)  Bjorn  Nordenvall,  Ph.D.,  M.D.,  with  residence at 319  Malborough,
          Boston MA 02116, USA (hereinafter referred to as "the Executive"); and

     (2)  OXiGENE Inc., a Delaware  corporation with its principal office at 321
          Arsenal Street,  Watertown,  MA 02472 (hereinafter referred to as "the
          Company").

     (1)  and (2) hereinafter collectively referred to as "the Parties".

                                   WITNESSETH

     WHEREAS the Parties  entered  into an Executive  Employment  Agreement on 9
October  1995,  as  amended  by  addendums  on 1  July  1999  and  1  July  2001
(hereinafter "the Agreement");

     WHEREAS the Parties wish to agree on certain matters in connection with the
termination of the Executive's employment as CEO with the Company;

     NOW THEREFORE,  the Parties to this Addendum  (hereinafter  "the Addendum")
hereby agree as follows:

1. Definitions and Interpretation

     1.1 Terms defined in the Agreement shall have the same respective  meanings
in this Addendum unless the context otherwise requires.

     1.2 Subject to the provisions of this Addendum:

          -    the Agreement  shall remain in full force and effect and shall be
               read and construed as one document with this Addendum

          -    nothing in this Addendum shall  constitute a waiver or release of
               any rights under the Agreement,  or otherwise prejudice any right
               or remedy either of the Parties have under the Agreement.

2. Effective Date

     This Addendum shall take effect from 23rd April, 2002.

3. Discontinuance of the Executive's Employment with the Company

     3.1 It is hereby agreed that the  Executive's  resign from his functions as
CEO of the Company in connection with the annual general meeting of shareholders
in the Company on 11 June 2002. The  Employment  Term shall end on 30 June 2002.
In  connection  herewith  the  Executive  shall he entitled to receive,  and the
Company shall pay, compensation as follows:

     3.1.1 The Company  shall pay to the Executive the Base Salary until 30 June
2002.

     3.1.2 The  Company  shall on or before 31 July 2002  effect a final  single
payment of salary of US$ 125,000 to the Executive.

     3.1.3 The Company  shall until 31 July 2002 provide the  residence  and car
benefits  to the  Executive  as they are  presently  being  provided  under  the
Agreement.

     This  Addendum  has been  executed on the date first  written  above in two
counterparts of which the Parties have taken one each.


The Company                                              The Executive

OXiGENE Inc.

/s/ Frederick Driscoll                                   /s/ Bjorn Nordenvall
- ----------------------                                   --------------------
President and CEO



                                ADDENDUM TO THE

                         EXECUTIVE EMPLOYMENT AGREEMENT

                               OF OCTOBER 9, 1995

- --------------------------------------------------------------------------------

This Addendum to the Executive Employment Agreement, originally dated October 9,
1995,  is executed  on May  __,2001,  to be  effective  on July 1, 2001,  by and
between  OXiGENE,  Inc. a Delaware  corporation with its principal office at 321
Arsenal  Street,  Watertown,  MA 02472 (the  "Company"),  and Bjorn  Nordenvall,
Ph.D.,  M.D.,  currently with a residence at 319 Marlborough,  Boston,  MA 02116
(the "Executive").  The parties to this Agreement are referred to, collectively,
as the "Parties".

Whereas,  the Parties  have  entered  into an  Executive  Employment  Agreement,
originally  dated October 9, 1995, and thereafter  amended,  of which the latest
amendment  is  dated  July 1,  1999  (as so  amended  to  date,  the  "Executive
Employment Agreement"); and.

Whereas, the Parties have agreed, taking into account the move of Executive from
Sweden to the United  States at the  request of the  Company and the role played
and  anticipated  by Executive  in the  Company's  success,  upon an increase in
Executive's  present  annual Base Salary of $225,000 to a new annual Base Salary
of $250,000 and the promise by the Company to Executive of a rent-free residence
and the use of an automobile in the Boston, Massachusetts, USA, area.

Now therefore the Parties agree as follows:

1.   The minimum annual Base Salary provided for in Section 2(a) ("Base Salary")
     of the  Executive  Employment  Agreement is hereby  amended to  $250,000.00
     (U.S.) per annum.

2.   The following shall be added to, and shall become and be a part of, Section
     4 ("Benefits") of the Executive Employment Agreement:

     (d)  Residence benefit.  The Company shall, during the period July 1, 2001,
          through and including June 30, 2002, make available to Executive,  for
          use by himself and his family,  a rent-free  residence  in the Boston,
          Massachusetts,  area on the terms herein set forth.  Pursuant  hereto,
          the  Company  shall  also bear the  expense of  electricity,  heating,
          water,  refuse  collection and other similar  expenses  related to the
          residence.  The  Executive  shall  approve a  residence  chosen by the
          Company,  and the Parties have  estimated  that the monthly rental due
          thereon shall be  approximately  $6,000.00  (excluding  other expenses
          associated with the expected occupancy and use of the premises).

     (e)  Car  benefit.  The  Company  shall,  during the  period  July 1, 2001,
          through and including June 30, 2002,  make  available  without cost to
          the Executive an automobile for use in connection  with his activities
          on behalf of the Company in the United States, and particularly in the
          Boston, Massachusetts, area. Pursuant hereto, the Company shall pay up
          to $600  per  month  for  the  cost of  usage  of the car and  related
          insurance.  Additionally,  the Company will pay for the lull operating
          costs  of  the  vehicle,   including  reasonable  fuel,   consumables,
          maintenance  and  repairs,  registration  and  licensing,  parking and
          tolls.

3.   The Parties hereto agree further that the provisions  hereinabove set forth
     shall be extended for an  additional  twelve month period if the  Executive
     Employment  Agreement  has not been  terminated on or before June 30, 2002,
     and the  Executive's  principal place of employment for the Company remains
     at the Company's principal office in the Boston, Massachusetts, area.

4.   This Addendum shall become  effective July 1, 2001, and, unless extended as
     set forth in Paragraph numbered 3 above, shall terminate on June 30, 2002.

5.   Except as set forth in this Addendum,  the Executive  Employment  Agreement
     and all prior  amendments  thereof and addenda  thereto  shall in all other
     respects be unchanged and remain in lull force and effect.

This  Addendum has been executed in two (2)  originals,  of which each Party has
retained one.

The Company                                 The Executive

OXiGENE, Inc.


/s/ Frederick Driscoll                      /s/ Bjorn Nordenvall
- ----------------------                      --------------------
    Frederick Driscoll                          Bjorn Nordenvall


.


                                    AMENDMENT
                                       TO
                          EXECUTIVE EMPLOYMENT CONTRACT


This Agreement is made and entered into on July 1, 1999, by and between OXiGENE,
Inc. a Delaware Corporation with its principal office at One Copley Place, Suite
602, Boston,  MA 02116 ("the Company"),  and Bjorn Nordenvall,  Ph.D.,  M.D., an
adult resident of Sweden ("the Executive").

WHEREAS, the Company and the Executive have entered into an Executive Employment
Agreement dated October 9, 1995 and an undated Addendum thereto,

WHEREAS,  the Company is at a phase where the work the  Executive  performs with
respect to commercializing the pharmaceutical products will increase,

WHEREAS, the Company's focus and the duties of the Executive has shifted towards
the United States,

WHEREAS,  the work the Executive performs with respect it investor relations has
increased and become more important to the Company, and

WHEREAS, the parties agree upon that the compensation the Executive has received
up to this date is to low for the services to be performed  in  comparison  with
executives of comparable pharmaceutical companies in the United States.

NOW, THEREFORE the parties agree as follows:

- -    Section 2 (a) ("Base  Salary") of the  Executive  Employment  Agreement  is
     Amended by replacing the minimum amount "$ 50,000.00" with $ 225,000.00.

In all other aspects, the Executive Employment Agreement with the change made in
the Addendum thereto shall be unchanged and remain in full force and effect.

This  amendment has been drawn in to originals,  of which the parties have taken
one each.



OXiGENE, Inc.                                Executive



By:   /s/ Bo Haglund                         /s/ Bjorn Nordenvall
      ----------------------------------     -----------------------------
          Bo Haglund                             Bjorn Nordenvall, Ph.D., M.D.
Title:    Chief Financial Officer