U.S. Securities and Exchange Commission
                             Washington, D.C. 20549


                                    Form 10-Q


           [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                  For the quarterly period ended March 31, 2001

          [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934
         For the transition period from _____________ to _______________

                         Commission File Number 0-21021


                            Enterprise Bancorp, Inc.
             (Exact name of registrant as specified in its charter)


                  Massachusetts                         04-3308902
        (State or other jurisdiction                   (IRS Employer
       of incorporation or organization)             Identification No.)

               222 Merrimack Street, Lowell, Massachusetts, 01852
               (Address of principal executive offices) (Zip code)

                                 (978) 459-9000
                         (Registrant's telephone number)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes ..X.... No......

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date:

April 30, 2001 Common Stock - Par Value $0.01, 3,411,167 shares outstanding































                                       1


                   ENTERPRISE BANCORP, INC.
                            INDEX
                                                                Page Number

    Cover Page                                                      1

    Index                                                           2

                        PART I FINANCIAL INFORMATION

Item 1     Financial Statements

  Consolidated Balance Sheets - March 31, 2000
     and December 31, 2000                                          3

  Consolidated Statements of Income -
  Three months ended March 31, 2001 and 2000                        4

  Consolidated Statements of Changes in Stockholders'
  Equity-Three months ended March 31, 2001                          5

  Consolidated Statements of Cash Flows -
  Three months ended March 31, 2001 and 2000                        6

  Notes to Financial Statements                                     8

Item 2     Management's Discussion and Analysis of
            Financial Condition and Results of Operations           9

Item 3     Quantitative and Qualitative Disclosures About
           Market Risk                                             17


                        PART II OTHER INFORMATION
Item 1     Legal Proceedings                                       18

Item 2     Changes in Securities and Use of Proceeds               18

Item 3     Defaults upon Senior Securities                         18

Item 4     Submission of Matters to a Vote of Security Holders     18

Item 5     Other Information                                       18

Item 6     Exhibits and Reports on Form 8-K                        18

           Signature Page                                          19

               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This report contains certain  "forward-looking  statements" including statements
concerning plans,  objectives,  future events or performance and assumptions and
other statements that are other than statements of historical  fact.  Enterprise
Bancorp,  Inc.  (the  "company")  wishes to caution  readers that the  following
important  factors,  among  others,  may adversely  affect the company's  future
results and could cause the company's  results for subsequent  periods to differ
materially  from those expressed in any  forward-looking  statement made herein:
(i) the effect of  unforeseen  changes  in  interest  rates;  (ii) the effect of
changes in the business  cycle and downturns in the local,  regional or national
economies,  including  unanticipated  deterioration  in the  local  real  estate
market;  (iii)  changes in asset  quality  and  unanticipated  increases  in the
company's reserve for loan losses; (iv) the effect on the company's  competitive
position  within its  market  area of the  increasing  competition  from  larger
regional and out-of-state banking organizations as well as non-bank providers of
various  financial  services;  (v)  the  effect  of  technological  changes  and
unanticipated technology-related expenses; (vi) the effect of unforeseen changes
in consumer  spending;  (vii) the effect of changes in laws and regulations that
apply to the company's  business and operations and  unanticipated  increases in
the company's  regulatory  compliance costs; (viii)  unanticipated  increases in
employee  compensation and benefit  expenses;  and (xi) the effect of changes in
accounting policies and practices,  as may be adopted by the regulatory agencies
as well as by the Financial Accounting Standards Board.



                                       2





                            ENTERPRISE BANCORP, INC.

                           Consolidated Balance Sheets


                                                                            March 31,          December 31,
                                                                              2001                 2000
($ in thousands)                                                           (Unaudited)
                                                                         -------------      ------------
Assets

Cash and cash equivalents
                                                                                            
Cash and due from banks                                               $         26,698            26,080
     Daily federal funds sold                                                   30,000            28,025
                                                                         -------------      ------------
               Total cash and cash equivalents                                  56,698            54,105

Investment securities at fair value                                            196,661           185,184
Loans, less allowance for loan losses of $6,459 at March 31,
      2001 and $6,220 at December 31 2000, respectively                        317,962           305,598
Premises and equipment                                                          10,960            10,903
Accrued interest receivable                                                      3,736             4,078
Deferred income taxes, net                                                       1,700             2,209
Prepaid expenses and other assets                                                3,069             2,735
Income taxes receivable                                                             28               415
Intangible assets, net of amortization                                           7,389             7,587
                                                                         -------------     -------------

               Total assets                                           $        598,203           572,814
                                                                         =============     =============

Liabilities, Trust Preferred Securities and Stockholders' Equity

Deposits                                                              $        472,948           461,975
Short-term borrowings                                                           70,610            58,271
Escrow deposits of borrowers                                                     1,238             1,106
Accrued expenses and other liabilities                                           3,352             3,418
Accrued interest payable                                                         1,019             1,389
                                                                         -------------     -------------

               Total liabilities                                               549,167           526,159
                                                                         -------------     -------------

Trust preferred securities                                            $         10,500            10,500

Stockholders' equity:
Preferred stock, $.01 par value; 1,000,000 shares
        authorized, no shares issued                                                 -                 -
Common stock $.01 par value; 10,000,000 shares authorized;
             3,409,542 and 3,408,667 shares issued and
             outstanding at March 31, 2001 and December 31, 2000,
             respectively                                                           34                34
Additional paid-in capital                                                      17,849            17,843
Retained earnings                                                               17,974            16,793
Accumulated other comprehensive income                                           2,679             1,485
                                                                         -------------    --------------
               Total stockholders' equity                                       38,536            36,155
                                                                         -------------    --------------
               Total liabilities, trust preferred
                securities and stockholders' equity                   $        598,203           572,814
                                                                         =============    ==============




                                       3





                         ENTERPRISE BANCORP, INC.

                     Consolidated Statements of Income

                 Three months ended March 31, 2001 and 2000

                                                                           March 31,         March 31,
($ in thousands, except per share data)                                      2001              2000
                                                                         (Unaudited)        (Unaudited)
                                                                      ----------------    --------------
Interest and dividend income:
                                                                                             
     Loans                                                            $          7,076             5,895
     Investment securities                                                       3,023             2,460
     Federal funds sold                                                            219                 -
                                                                         --------------   --------------
               Total interest income                                            10,318             8,355
                                                                         -------------    --------------
Interest expense:
     Deposits                                                                    3,290             2,680
     Short-term borrowings                                                         777               955
                                                                         -------------    --------------
               Total interest expense                                            4,067             3,635
                                                                         -------------    --------------

               Net interest income                                               6,251             4,720

Provision for loan losses                                                          210               126
                                                                         -------------    --------------
           Net interest income after provision for loan losses                   6,041             4,594
                                                                         -------------    --------------

Non-interest income:
     Investment management and trust service fees                                  506               333
     Deposit service fees                                                          346               214
     Net gains on sales of investment securities                                   390                 -
     Gains on sales of loans                                                        62                10
     Other income                                                                  202               111
                                                                         -------------    --------------
               Total non-interest income                                         1,506               668
                                                                         -------------    --------------

Non-interest expense:
     Salaries and employee benefits                                              3,261             2,345
     Occupancy expenses                                                            955               721
     Advertising and public relations                                              140                84
     Audit, legal and other professional fees                                      152               125
     Trust professional and custodial expenses                                     182                99
     Office and data processing supplies                                           139               102
     Trust preferred expense                                                       290                29
     Amortization of intangible assets                                             198                 -
     Other operating expenses                                                      609               451
                                                                         -------------    --------------
               Total non-interest expense                                        5,926             3,956
                                                                         -------------    --------------

Income before income taxes                                                       1,621             1,306
Income tax expense                                                                 440               337
                                                                         -------------    --------------
               Net income                                             $          1,181               969
                                                                         =============    ==============
Basic earnings per average common share outstanding                   $           0.35              0.30
                                                                         =============    ==============
Diluted earnings per average common share outstanding                 $           0.34              0.29
                                                                         =============    ==============
Basic weighted average common shares outstanding                             3,409,093         3,230,538
                                                                         =============    ==============
Diluted weighted average common shares outstanding                           3,489,837         3,324,767
                                                                         =============    ==============


                                       4






                            ENTERPRISE BANCORP, INC.

           Consolidated Statements of Changes in Stockholders' Equity

                        Three months ended March 31, 2001


                                 Common Stock            Additional                   Comprehensive Income        Total
                           --------------------------     Paid-in      Retained     -----------------------     Stockholders'
($ in thousands)            Shares            Amount      Capital      Earnings      Period    Accumulated        Equity
                           ----------      ----------   -----------   -----------   --------   ------------     -----------


                                                                                                
Balance at December         3,408,667         $ 34        $ 17,843     $ 16,793                 $ 1,485           $36,155
31, 2000
Comprehensive income
 Net income                                                               1,181      $ 1,181                        1,181
 Unrealized appreciation
   on securities, net of
   reclassification                                                                    1,194      1,194             1,194
                                                                                     -------
Total comprehensive income,                                                          $ 2,375
 net of tax                                                                          =======

Stock options exercised           875            -               6                                                      6
                            ---------       ------        --------     ---------               --------           -------
Balance at March 31,        3,409,542         $ 34        $ 17,849     $ 17,974                $  2,679           $38,536
 2001                       =========       ======        ========     =========               ========           =======

Disclosure of reclassification amount:
Gross unrealized holding appreciation                                                $ 2,198
arising during the period Tax expense                                                   (747)
                                                                                     -------
Unrealized holding appreciation, net                                                   1,451
of tax                                                                               -------
Less: reclassification adjustment for
net gains included in net income (net                                                    257
of $133 tax)                                                                         -------
Net unrealized appreciation on                                                       $ 1,194
securities                                                                           =======



























                                       5







                                   ENTERPRISE BANCORP, INC.

                            Consolidated Statements of Cash Flows

                          Three months ended March 31, 2001 and 2000

                                                                    March 31,          March 31,
                                                                      2001               2000
($ in thousands)                                                  (Unaudited)         (Unaudited)
                                                                ---------------   ---------------

Cash flows from operating activities:
                                                                                      
     Net income                                                $        1,181               969
     Adjustments to reconcile net income to net
        cash provided by operating activities:
           Provision for loan losses                                      210               126
           Depreciation and amortization                                  530               393
           Amortization of intangible assets                              198                 -
           Net gains on sales of investment securities                   (390)                -
           Gains on sales of loans                                        (62)              (10)
           (Increase) decrease in:
               Loans held for sale                                        311               752
               Accrued interest receivable                                342                80
               Prepaid expenses and other assets                         (334)           (1,007)
               Deferred income taxes                                     (105)              (63)
               Income taxes receivable                                    387                15
           Increase (decrease) in:
               Accrued expenses and other liabilities                     (66)             (939)
               Accrued interest payable                                  (370)              148
                                                                -------------    --------------
                  Net cash provided by operating activities             1,832               464
                                                                -------------    --------------

Cash flows from investing activities:
     Proceeds from maturities, calls and paydowns
        of investment securities                                        4,091             1,488
     Proceeds from sales of investment securities                      10,037                 -
     Purchase of investment securities                                (23,437)          (15,347)
     Net increase in loans                                            (12,823)           (4,410)
     Additions to premises and equipment, net                            (557)             (548)
                                                                -------------    --------------
                  Net cash used in investing activities               (22,689)          (18,817)
                                                                -------------    --------------

Cash flows from financing activities:
     Net increase in deposits, including escrow deposits               11,105            33,131
     Net increase (decrease) in short-term borrowings                  12,339           (25,892)
     Proceeds from issuance of trust preferred securities                   -            10,500
     Stock options exercised                                                6               383
                                                                -------------    --------------
                  Net cash provided by financing activities            23,450            18,122
                                                                -------------    --------------

Net increase (decrease) in cash and cash equivalents                    2,593              (231)

Cash and cash equivalents at beginning of period                       54,105            17,089
                                                                -------------    --------------

Cash and cash equivalents at end of period                     $       56,698            16,858
                                                                =============    ==============


                                       6






                                   ENTERPRISE BANCORP, INC.

                            Consolidated Statements of Cash Flows
                                         (Continued)

                          Three months ended March 31, 2001 and 2000


Supplemental financial data:
     Cash paid for:
                                                                                    
        Interest expense                                     $          4,722             3,487
        Income taxes                                                      200               438



















































                                       7


                            ENTERPRISE BANCORP, INC.
                          Notes to Financial Statements

(1)      Organization of Holding Company

Enterprise Bancorp, Inc. (the "company") is a Massachusetts  corporation,  which
was  organized on February 29, 1996,  at the  direction of  Enterprise  Bank and
Trust Company,  a Massachusetts  trust company (the "bank"),  for the purpose of
becoming the holding company for the bank.

(2)      Basis of Presentation

The accompanying  unaudited  financial  statements should be read in conjunction
with the company's  December 31, 2000,  audited  financial  statements and notes
thereto.  Interim  results  are not  necessarily  indicative  of  results  to be
expected for the entire year.

In preparing the financial statements,  management is required to make estimates
and assumptions that affect the reported amounts of assets and liabilities as of
the date of the balance  sheet and revenues and expenses for the period.  Actual
results  could  differ  from  those  estimates.   Material  estimates  that  are
particularly  susceptible to change relate to the determination of the allowance
for loan losses.

In the opinion of management,  the accompanying financial statements reflect all
necessary  adjustments  consisting  of  normal  recurring  accruals  for a  fair
presentation.

(3)      Earnings Per Share

Basic  earnings per share are  calculated  by dividing net income by the year to
date  weighted  average  number of common shares that were  outstanding  for the
period. Diluted earnings per share reflect the effect on weighted average shares
outstanding  of the number of additional  shares  outstanding  if dilutive stock
options were converted  into common stock using the treasury  stock method.  The
increase in average shares outstanding, using the treasury stock method, for the
diluted  earnings per share  calculation were 80,744 and 94,229 for the quarters
ended March 31, 2001 and March 31, 2000, respectively.

(4)      Dividend Reinvestment Plan

The company maintains a Dividend  Reinvestment Plan (the "DRP"). The DRP enables
stockholders,  at their discretion, to elect to reinvest dividends paid on their
outstanding  shares of company common stock by purchasing  additional  shares of
company  common stock from the  company.  The  stockholders  utilized the DRP to
reinvest  $493,000  of the  dividends  paid by the  company in 2000 into  47,800
shares of the company's common stock.

(5)      Fleet Branch Acquisition

On July 21, 2000 the bank  completed its  acquisition of two Fleet National Bank
branch offices (the "Fleet  branches").  The excess of cost over the fair market
value of assets acquired and liabilities  assumed of approximately  $7.9 million
has been  allocated  to  identified  intangible  assets and  goodwill  (combined
"intangible assets") and is being amortized over a ten-year period.

(6)      Trust Preferred Securities

On March 10, 2000 the company  organized  Enterprise  (MA) Capital  Trust I (the
"Trust"),  a statutory  business  trust created under the laws of Delaware.  The
company  is the owner of all the common  shares of  beneficial  interest  of the
Trust.  On March 23,  2000 the Trust  issued  $10.5  million  of  10.875%  trust
preferred securities. The trust preferred securities have a thirty year maturity
and may be  redeemed at the option of the Trust  after ten years.  The  proceeds
from the sale of the trust preferred  securities  were used by the Trust,  along
with the company's $0.3 million capital  contribution,  to acquire $10.8 million
in aggregate  principal  amount of the  company's  10.875%  Junior  Subordinated
Deferrable   Interest   Debentures  due  2030.  The  company  has,  through  the
Declaration  of  Trust  establishing  the  Trust,   fully  and   unconditionally
guaranteed on a subordinated  basis all of the Trust's  obligations with respect
to distributions and amounts payable upon liquidation, redemption or repayment.

(7)      Reclassification

Certain fiscal 2000  information  has been  reclassified  to conform to the 2001
presentation.

                                       8


ITEM 2 - Management's Discussion and Analysis of Financial Condition and Results
         of Operations

Capital Resources

The company's  actual capital amounts and capital  adequacy ratios are presented
in the table  below.  The  bank's  capital  amounts  and  ratios  do not  differ
materially from the amounts and ratios presented.



                                                                   Minimum Capital              Minimum Capital
                                                                     for Capital                     to be
                                          Actual                 Adequacy Purposes             Well Capitalized
                                 -------------------------   ------------------------    ---------------------------
($ in thousands)                     Amount        Ratio        Amount         Ratio        Amount          Ratio
                                 --------------  ---------   -------------  ---------    ------------   ------------

As of March 31, 2001:

Total Capital
                                                                                         
   (to risk weighted assets)     $       43,618     11.93%   $      23,837      8.00%    $     29,797      10.00%

Tier 1 Capital
   (to risk weighted assets)             39,023     10.67%          11,919      4.00%          17,878       6.00%

Tier 1 Capital*
   (to average assets)                   39,023      6.96%          17,902      4.00%          22,378       5.00%

          * For the bank to qualify as "well  capitalized",  it must  maintain a
          leverage  capital ratio (Tier 1 capital to average assets) of at least
          5%. This  requirement  does not apply to the company and is  reflected
          merely for informational purposes with respect to the bank.


On April 17, 2001,  the board of directors  declared a dividend in the amount of
$0.2875 per share to be paid on or about June 28, 2001 to shareholders of record
as of the close of business on June 8, 2001.  The board of directors  intends to
consider the payment of future dividends on an annual basis.

Balance Sheet

Total Assets

Total assets  increased  $25.4  million,  or 4.4 %, since December 31, 2000. The
increase is primarily  attributable  to increases in  investment  securities  of
$11.5  million  and gross  loans of $12.6  million.  The  increase in assets was
funded  primarily by growth in deposits and  short-term  borrowings of $11.1 and
$12.3 million, respectively.

Investments

At March 31, 2001 all of the bank's  investment  securities  were  classified as
available-for-sale and carried at fair value. The net unrealized appreciation at
March 31, 2001 was $4.1  million  compared to $2.3 million at December 31, 2000.
The net  unrealized  appreciation/depreciation  in the  portfolio  fluctuates as
interest  rates  rise and fall.  Due to the  fixed  rate  nature  of the  bank's
investment portfolio,  as rates rise the value of the portfolio declines, and as
rates fall the value of the portfolio  rises. The unrealized  appreciation  will
only be realized if the securities are sold. The unrealized  appreciation on the
investment  portfolio  will decrease as interest rates rise or as the securities
approach maturity.

Loans

Total loans, before the allowance for loan losses, were $324.4 million, or 54.2%
of total  assets,  at March 31, 2001,  compared to $311.8  million,  or 54.4% of
total assets,  at December 31, 2000.  The increase in loans of $12.6 million for
the quarter ended March 31, 2001 was primarily  attributed to  originations  for
commercial and commercial real estate loans and drawdowns on commercial lines of
credit.

                                       9


Deposits and Borrowings

Total deposits, including escrow deposits of borrowers, increased $11.1 million,
or 2.4%,  during the first three months of 2001, from $463.1 million at December
31, 2000,  to $474.2  million at March 31, 2001.  The increase of $11.1  million
consists  of growth of $25.9  million  in  savings,  checking  and money  market
deposits   primarily   attributable  to  sales  efforts  and  increased   market
penetration,  offset by a $14.8  million  decrease  in  certificates  of deposit
primarily  attributable  to interest rate decreases  during the first quarter of
2001.

Short-term  borrowings,  consisting  of  securities  sold  under  agreements  to
repurchase  and Federal  Home Loan Bank  ("FHLB")  borrowings,  increased  $12.3
million,  or 21.2%,  from $58.3 million at December 31, 2000 to $70.6 million at
March 31,  2001.  The  increase was  primarily  attributable  to growth of $12.4
million  in  commercial  sweep  balances,   which  along  with  term  repurchase
agreements are classified as securities sold under agreements to repurchase. The
bank had $470,000 in borrowings outstanding from the FHLB at March 31, 2001.


Loan Loss Experience/Non-performing Assets

The following table summarizes the activity in the allowance for loan losses for
the periods indicated:



                                                                      Three months ended March 31,
($ in thousands)                                                      2001                     2000
                                                                 -------------            --------------

                                                                                             
Balance at beginning of year                                  $          6,220                     5,446
Loans charged-off
     Commercial                                                              -                        24
     Commercial real estate                                                  -                         -
     Construction                                                            -                         -
     Residential real estate                                                 -                         -
     Home equity                                                             -                         -
     Other                                                                  20                         2
                                                                 -------------            --------------
                                                                            20                        26

Recoveries on loans charged off
     Commercial                                                             25                        21
     Commercial real estate                                                  -                        11
     Construction                                                            -                         -
     Residential real estate                                                20                         -
     Home equity                                                             -                         -
     Other                                                                   4                         -
                                                                 -------------            --------------
                                                                            49                        32

Net loan recoveries                                                         29                         6
Provision charged to operations                                            210                       126
                                                                 -------------            --------------
Balance at March 31                                           $          6,459                     5,578
                                                                 =============            ==============

Annualized net recoveries: Average loans outstanding                     0.04%                     0.01%
                                                                 =============            ==============
Allowance for loan losses: Gross loans                                   1.98%                    2.10%
                                                                 =============            ==============
Allowance for loan losses: Non-performing loans                        614.56%                  242.21%
                                                                 =============            ==============



                                       10






The following table sets forth non-performing assets at the dates indicated:

($ in thousands)                                          March 31,     December 31,    March 31,
                                                            2001            2000           2000
                                                       -------------    -------------   -------------
                                                                                       
Non-accrual loans                                      $       1,051            1,054           2,294
Accruing loans > 90 days past due                                  -               26               9
                                                       -------------    -------------   -------------
Total non-performing loans                                     1,051            1,080           2,303
Other real estate owned                                            -                -               -
                                                       -------------    -------------   -------------
     Total non-performing assets                    $          1,051            1,080           2,303
                                                       =============    =============   =============

Non-performing loans: Gross loans                              0.32%            0.34%           0.87%
                                                       =============    =============   =============
Non-performing assets: Total assets                            0.18%            0.19%           0.50%
                                                       =============    =============   =============
Delinquent loans 30-89 days past due: Gross loans              0.18%            0.14%           0.41%
                                                       =============    =============   =============


Total non-performing  assets decreased $1.3 million from March 31, 2000 to March
31, 2001, and the ratio of  non-performing  loans to gross loans  decreased from
0.50% to 0.18% over the same period. The decreases are primarily attributable to
non-performing  loans paid off and a strong  economy  during 2000.  The level of
non-performing  assets is  largely a function  of  economic  conditions  and the
overall  banking  environment,  as  well  as the  strength  of the  bank's  loan
underwriting.    Adverse  changes  in  local,   regional  or  national  economic
conditions could  negatively  impact the level of  non-performing  assets in the
future, despite prudent underwriting.


































                                       11




                              Results of Operations
     Three Months Ended March 31, 2001 vs. Three Months Ended March 31, 2000

The company  reported net income of $1,181,000  for the three months ended March
31, 2001, versus $969,000 for the three months ended March 31, 2000. The company
had basic earnings per common share of $0.35 and $0.30 and diluted  earnings per
share of $0.34 and $0.29 for the three  months  ending  March 31, 2001 and March
31, 2000, respectively.

The following table highlights  changes,  which affected the company's  earnings
for the periods indicated:



                                                            Three months ended March 31,
($ in thousands)                                            2001                     2000
                                                       -------------            --------------

                                                                              
Average assets (1)                                    $      569,020                   451,006
Average deposits and short-term borrowings                   518,825                   416,031
Average investment securities and fed funds sold (1)         209,924                   164,628
Average loans, net of deferred loan fees                     315,273                   260,128
Net interest income                                            6,251                     4,720
Provision for loan losses                                        210                       126
Tax expense                                                      440                       337
Average loans: Average deposits and borrowings                60.77%                    62.53%
Non-interest expense: Average assets (2)                       4.22%                     3.53%
Non-interest income: Average assets (2) (3)                    0.80%                     0.60%
Average tax equivalent rate earned on interest                 8.14%                     8.11%
earning assets
Average rate paid on interest bearing deposits and
   short-term borrowings                                       3.92%                     4.20%
Net interest margin                                            5.00%                     4.67%

(1) Excludes the effect of SFAS No. 115
(2) Ratios have been annualized based on number of days for the period
(3)Excludes net gains on sales of investment securities


Net Interest Income

The  company's  net interest  income was  $6,251,000  for the three months ended
March 31, 2001, an increase of $1,531,000 or 32.4% from $4,720,000 for the three
months ended March 31, 2000.  Interest income  increased  $1,963,000,  primarily
resulting from  increases in average loan balances of $55.1  million,  or 21.2%,
and average investment security and fed funds sold balances of $45.3 million, or
27.5%,  from the quarter  ended  March 31,  2000 to the quarter  ended March 31,
2001. Included in the average loan balance at March 31, 2001 are $7.0 million in
loans  purchased from Fleet  National Bank. The increase in interest  income was
partially offset by an increase in interest  expense of $432,000,  primarily due
to an increase of $508,000 in savings,  personal  interest  checking ("PIC") and
money market  interest  expense  resulting from an average  balance  increase of
$81.3  million and an  increases in time  deposit  interest  expense of $102,000
offset by a decrease in short-term  borrowing  expense of $178,000 over the same
period.  The average  balance on time  deposits  decreased to $150.9  million at
March 31, 2001 from $153.9  million at March 31,  2000.  The average  balance on
short-term  borrowings  decreased to $62.8  million at March 31, 2001 from $67.8
million at March 31,  2000.  The change  consists of an  increase in  repurchase
agreements  of $32.5  million  offset by a decrease in FHLB  borrowings of $37.5
million.  Included in the average  deposit  balance at March 31, 2001 are $34.7,
$14.0 and $9.6  million in  savings/PIC/MMDA,  time,  and  non-interest  bearing
deposits, respectively, assumed from Fleet National Bank on July 21, 2000.

The average  tax-equivalent  yield on earning  assets in the three  months ended
March 31,  2001,  was 8.14%,  up 3 basis  points from 8.11% in the three  months
ended March 31, 2000.  The average rate earned on loans  decreased 1 basis point
from  9.11% at March  31,  2000 to 9.10% at March  31,  2001.  The  average  tax
equivalent rate earned on investment  securities increased to 6.79% at March 31,
2001  from 6.53 % at March  31,  2000  primarily  due to  investment  securities
purchased  during  the 2nd  quarter of 2000 when  market  rates were at a higher
point in the interest rate cycle.


                                       12



The average rate paid on interest bearing deposits and short-term borrowings for
the three months ended March 31, 2001,  was 3.92%, a decrease of 28 basis points
from 4.20% for the three  months ended March 31, 2000.  The  resulting  interest
rate spread  increased 31 basis points to 4.22% for the three months ended March
31, 2001, from 3.91% for the three months ended March 31, 2000. The average rate
paid on savings/PIC/money markets accounts increased to 2.42% from 2.33% for the
period  ended  March 31, 2001  versus the same  period in 2000,  primarily  from
growth in tiered rate  business  savings and tiered rate  personal  money market
accounts,  which were  introduced in late 1999 and mid 2000,  respectively.  The
average  rate paid on  certificates  of deposit  increased to 5.51% at March 31,
2001 compared to 5.09% March 31, 2000. The increase is primarily attributable to
higher market rates on certificates  of deposit  originated in 2000. The average
rate paid on short-term  borrowings,  which includes  repurchase  agreements and
FHLB  borrowings,  decreased  from 5.66% at March 31, 2000 to 5.02% at March 31,
2001  primarily due to pay downs of higher costing FHLB  borrowings,  which were
accomplished in part through the use of the net proceeds received by the bank in
connection with the Fleet Branch acquisition.

Net interest margin increased to 5.00% at March 31, 2001 from 4.67% at March 31,
2000,  primarily due to the 28 basis point decrease in the rate paid on interest
bearing  deposits and  short-term  borrowings  and the 3 basis point increase in
yield on interest earning assets.



The following table sets forth,  among other things, the extent to which changes
in interest rates and changes in the average balances of interest-earning assets
and  interest-bearing  liabilities  have  affected  interest  income and expense
during the three months ended March 31, 2001, and March 31, 2000,  respectively.
For each category of interest-earning  assets and interest-bearing  liabilities,
information  is  provided  on changes  attributable  to:  (1) volume  (change in
average portfolio  balance  multiplied by prior year average rate); (2) interest
rate (change in average interest rate multiplied by prior year average balance);
and (3) rate and volume (the remaining difference).






































                                       13





                                                  AVERAGE BALANCES, INTEREST AND AVERAGE INTEREST RATES

                                          Three Months Ended March 31, 2001             Three Months Ended March 31, 2000
                                        -------------------------------------       -------------------------------------------
                                          Average                    Interest         Average                         Interest
($ in thousands)                          Balance     Interest       Rates (3)        Balance        Interest         Rates (3)
                                        ----------  ------------     ---------      ------------   --------------     ---------
Assets:
                                                                                                 
    Loans  (1)  (2)                     $  315,273  $    7,076         9.10%         $  260,128      $    5,895          9.11%
    Investment securities (3)  (5)         194,120       3,023         6.79             164,628           2,460          6.53
    Federal funds sold                      15,804         219         5.61                   -               -             -
                                        ----------  ----------                       ----------      ----------
    Total interest earnings assets         525,197      10,318         8.14%            424,756           8,355          8.11%
                                                    ----------                                       ----------
    Other assets (4) (5)                    43,823                                       26,250
                                        ----------                                   ----------
      Total assets  (5)                 $  569,020                                   $  451,006
                                        ==========                                   ==========

Liabilities and stockholders' equity:
    Savings/PIC/MMDA                    $  207,408       1,238         2.42%         $  126,074            730            2.33%
    Time deposits                          150,947       2,052         5.51             153,941          1,950            5.09
    Short-term borrowings                   62,813         777         5.02              67,838            955            5.66
    Interest bearing deposits and          421,168       4,067         3.92%            347,853          3,635            4.20%
     Borrowings                         ----------  ----------                       ----------

    Non-interest bearing deposits           97,657                                      68,178
    Other liabilities                        3,670                                       3,039
                                        ----------                                  ----------
      Total liabilities                    522,495                                     419,070

Trust preferred securities                  10,500                                       1,038

Stockholders' equity  (5)                   36,025                                      30,898
                                        ----------                                  ----------

  Total liabilities, trust preferred
  securities and stockholders' equity   $  569,020                                  $  451,006
   (5)                                  ==========                                  ==========

Net interest rate spread                                               4.22%                                             3.91%

Net interest income                     $    6,251                                                $    4,720
                                        ==========                                                ==========

Net interest margin                                                    5.00%                                             4.67%


















                                       14





                                                          Changes due to
($ in thousands)                    -----------------------------------------------------------------
                                                                        Interest             Rate/
Assets:                             Total              Volume             Rate               Volume
                                    ----------     ------------        -----------        -----------
                                                                        
    Loans  (1)  (2)                 $   1,181      $    1,239         $       (8)         $     (50)
    Investment securities (3)  (5)        563             475                105                (17)
    Federal funds sold                    219             219                  -                  -
                                    ----------     ------------        -----------        -----------
    Total interest earnings assets      1,963           1,933                 97                (67)
                                    ----------     ------------        -----------        -----------
    Other assets (4) (5)


      Total assets  (5)

Liabilities and stockholders' equity:
    Savings/PIC/MMDA                      508             467                 29                 12
    Time deposits                         102             (38)               159                (19)
    Short-term borrowings                (178)            (70)              (108)                 -
                                     ---------      -----------        -----------        -----------
Interest bearing deposits and
     Borrowings                     $     432             359                 80                 (7)
                                     ---------      -----------        -----------        -----------
    Non-interest bearing deposits
    Other liabilities
      Total liabilities

Trust preferred securities

Stockholders' equity  (5)


  Total liabilities, trust preferred
  securities and stockholders' equity
   (5)

Net interest rate spread

Net interest income                     1,531      $    1,574         $       17         $      (60)
                                      =========     ============       ============       ============

Net interest margin



(1)  Average loans include non-accrual loans.
(2)  Average loans are net of average deferred loan fees.
(3)  Average  balances  are  presented  at average  amortized  cost and  average
     interest rates are presented on a tax-equivalent basis.
(4)  Other assets include cash and due from banks,  accrued interest receivable,
     allowance for loan losses,  deferred income taxes,  intangible  assets, and
     other miscellaneous assets.
(5)  Excludes the effect of SFAS No. 115

The bank manages its earning assets by fully using available  capital  resources
within what  management  believes are prudent  credit and  leverage  parameters.
Loans, investment securities, and federal funds sold comprise the bank's earning
assets.









                                       15


Provision for Loan Losses

The  provision  for loan losses  amounted to $210,000 and $126,000 for the three
months  ended March 31, 2001 and March 31,  2000,  respectively.  The  provision
reflects  real  estate  values and  economic  conditions  in New  England and in
Greater  Lowell,  in  particular,  the  level of  non-accrual  loans,  levels of
charge-offs  and  recoveries,  levels of outstanding  loans,  known and inherent
risks in the nature of the loan portfolio and management's assessment of current
risk.  The  provision  for loan  losses is a  significant  factor in the  bank's
operating results.

Non-Interest Income

Non-interest  income  increased by $838,000 to  $1,506,000  for the three months
ended March 31, 2001,  compared to $668,000 for the three months ended March 31,
2000.  This increase was primarily  caused by increases in net gains on security
sales of $390,000,  investment  management  and trust  service fees of $173,000,
deposit  service  fees of  $132,000,  gains on loan sales of  $52,000  and other
income of $91,000.

Net gains on sales of investment  securities amounted to $390,000 and $0 for the
three months ended March 31, 2001 and March 31,  2000,  respectively.  The gains
resulted  from  management's  decision to take  advantage of certain  investment
opportunities and asset/liability repositioning.

Investment  management and trust service fees  increased by $173,000,  or 52.0%,
for the three  months  ended March 31, 2001  compared to the same period in 2000
due to an  increase  in trust  assets  and the  establishment  of an  investment
services unit.  Trust assets  increased from $238.8 million at March 31, 2000 to
$276.2 million at March 31, 2001.

Deposit service fees increased by $132,000, or 61.7%, for the three months ended
March 31, 2001, compared to the three months ended March 31, 2000, due primarily
to an increase in savings, checking and money market balances of $124.0 million,
or 60% from March 31,  2000 to March 31,  2001.  The  deposit  balance  increase
resulted in higher checking and overdraft fees.  Included in the  aforementioned
deposit  growth are $44.3  million in savings,  PIC, and money  market  balances
assumed from Fleet National Bank on July 21, 2000.

Gains on loan sales  increased  by $52,000 for the three  months ended March 31,
2001,  compared to the three  months  ended March 31,  2000,  due  primarily  to
decreases in interest rates  beginning in December of 2000 that have resulted in
increased refinance and sales volume.

Other income for the three months ended March 31, 2001, was $202,000 compared to
$111,000 for the three months ended March 31, 2000,  due  primarily to increases
in debit card fees, ATM  surcharges,  check printing fees, safe deposit fees and
wire transfer fees.

Non-Interest Expenses

Salaries  and benefits  expense  totaled  $3,261,000  for the three months ended
March 31, 2001,  compared with  $2,345,000  for the three months ended March 31,
2000,  an increase of $916,000 or 39.1%.  This increase was primarily due to the
acquisition  of the Fleet  branches,  new hires  due to bank  growth,  strategic
initiatives implemented by the bank, and annual pay raises.

Occupancy  expense was  $955,000  for the three  months  ended  March 31,  2001,
compared with $721,000 for the three months ended March 31, 2000, an increase of
$234,000 or 32.5%.  The increase was  primarily  due to the  acquisition  of the
Fleet branches,  office renovations for operational support departments and loan
officers and ongoing enhancements to the bank's computer systems.

Advertising  and public  relations  expenses  increased by $56,000 for the three
months ended March 31, 2001 compared to the same period in 2000 primarily due to
the timing of expenses associated with the advertising programs and bank growth.

Audit, legal and other professional  expenses increased by $27,000 for the three
months  ended  March 31,  2001  compared  to the same  period in 2000  primarily
resulting from increased  compliance and audit related expenses  associated with
the bank's growth.

                                       16


Trust  professional  and custodial  expenses  increased by $83,000 for the three
months ended March 31, 2001 as compared to the same period in 2000. The increase
was  primarily  due to asset growth and an increase in  professional  management
fees as a percentage of assets.

Office and data processing  supplies expense  increased by $37,000 for the three
months  ended March 31, 2001  compared to the same period in 2000.  The increase
was primarily due to the timing of purchases and growth.

Trust  preferred  expense was  $290,000  and $29,000 for the three  months ended
March  31,  2001 and March 31,  2000,  respectively.  The  expense  consists  of
interest  costs and the  amortization  of deferred  underwriting  costs from the
trust preferred securities issued on March 23, 2000.

Amortization of intangible assets was $198,000 and $0 for the three months ended
March  31,  2001 and March 31,  2000,  respectively.  The  expense  consists  of
intangible  assets  acquired in  connection  with the Fleet branch  acquisition,
which are being amortized over ten years.

Other  operating  expense was  $609,000  and $451,000 for the three months ended
March 31, 2001 and March 31,  2000,  respectively.  The  increase of $158,000 is
primarily due to the bank's growth and consists of increased expenses for ATM's,
courier services,  general insurance,  telephone,  postage, internet banking and
EDP system security.

Income Tax Expense

Income tax expense and the  effective  tax rate for the three months ended March
31,  2001 and March 31, 2000 were  $440,000  and 27.1% and  $337,000  and 25.8%,
respectively.  The increase in effective tax rate resulted primarily from higher
pre-tax income which decreases the impact of tax exempt municipal income.


ITEM 3 - Quantitative and Qualitative Disclosures About Market Risk

The company's primary market risk is interest rate risk,  specifically,  changes
in the interest rate environment. The bank's investment committee is responsible
for establishing  policy guidelines on acceptable exposure to interest rate risk
and liquidity.  The investment  committee is comprised of certain members of the
Board of  Directors  and  certain  members  of senior  management.  The  primary
objectives of the company's  asset/liability policy is to monitor,  evaluate and
control the bank's  interest rate risk,  as a whole,  within  certain  tolerance
levels while ensuring adequate  liquidity and adequate  capital.  The investment
committee  establishes  and  monitors  guidelines  for the net  interest  margin
sensitivity,  equity and capital ratios,  liquidity, FHLB borrowing capacity and
loan to deposit ratio. The asset/liability  strategies are reviewed regularly by
management and presented and discussed with the investment committee on at least
a quarterly basis. The  asset/liability  strategies are revised based on changes
in  interest  rate  levels,  general  economic  conditions,  competition  in the
marketplace,  the current position of the bank,  anticipated  growth of the bank
and other factors.

One of the  principal  factors in  maintaining  planned  levels of net  interest
income is the  ability to design  effective  strategies  to manage the impact of
changes in  interest  rates on future net  interest  income.  The  balancing  of
changes in interest income from interest  earning assets and interest expense of
interest  bearing  liabilities  is  accomplished   through  the  asset/liability
management  program.  The bank's simulation model analyzes various interest rate
scenarios.  Variations in the interest rate environment affect numerous factors,
including prepayment speeds,  reinvestment rates, maturities of investments (due
to call provisions), and interest rates on various asset and liability accounts.
The  investment  committee   periodically  reviews  guidelines  or  restrictions
contained in the asset/liability policy and adjusts them accordingly. The bank's
current  asset/liability  policy is designed to limit the impact on net interest
income to 10% in the 24 month period  following the date of the  analysis,  in a
rising and falling rate shock analysis of 100 and 200 basis points.

Management  believes  there have been no material  changes in the interest  rate
risk  reported in the  company's  Annual  Report on Form 10-K for the year ended
December 31, 2000.

                                       17


                            PART II OTHER INFORMATION


Item 1            Legal Proceedings
                  Not Applicable

Item 2            Changes in Securities and Use of Proceeds
                  Not Applicable

Item 3            Defaults upon Senior Securities
                  Not Applicable

Item 4            Submission of Matters to a Vote of Security Holders
                  Not Applicable

Item 5            Other Information
                  None

Item 6            Exhibits and Reports on Form 8-K
                  The following exhibits are included with this Report:



                  27.0           Financial data schedule (electronic copy only)














































                                       18




                                   SIGNATURES


Pursuant to the  requirements  of the  Securities  and Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


                                      ENTERPRISE BANCORP, INC.

DATE:  May  11, 2001                  /s/ John P. Clancy, Jr.
                                      ------------------------
                                      John P. Clancy, Jr.
                                      Treasurer
























































                                       19