SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

 Date of Report (Date of Earliest Event Reported): March 7, 2003 (March 5, 2003)

                              --------------------


                            ENTERPRISE BANCORP, INC.
               (exact name of registrant as specified in charter)

Massachusetts                     0-21021                   04-3308902
(State or Other Jurisdiction     (Commission                (IRS Employer
of Incorporation)                 File Number)              Identification No.)

222 Merrimack Street                                        01852
Lowell, Massachusetts                                       (Zip Code)
(address of principal office)

                                 (508) 459-9000
              (Registrant's telephone number, including area code)






Item 9.   Regulation FD Disclosure.

          On March 5, 2003,  Massachusetts  Governor Mitt Romney signed into law
          legislation  intended to close a projected  $650 million  state budget
          deficit for the current  fiscal year ending on June 30, 2003.  The new
          law includes, among other revenue enhancing provisions, changes to the
          state's  tax laws that are applied to banking  organizations,  such as
          the Registrant, on a retroactive basis to include prior tax years back
          to the year ended on December 31, 1999. This change in the law affects
          the  taxation  of  income  earned  by  the  Registrant's  real  estate
          investment trust  subsidiary,  Enterprise  Realty Trust, Inc. ("ERT"),
          and as explained further below will result in the Registrant recording
          a one-time  income tax expense of $2.3 million,  net of federal income
          tax benefit.  This expense will not effect the  Registrant's  earnings
          for the year ended  December  31,  2002,  but will be  included in the
          Registrant's first quarter ending on March 31, 2003.

          The   Registrant   is   currently   engaged  in  a  dispute  with  the
          Massachusetts  Department of Revenue (the "DOR") as to whether  income
          earned  by ERT  and  paid as  dividends  to the  Registrant's  banking
          subsidiary,  Enterprise  Bank  and  Trust  Company  ("EBTC"),  may  be
          substantially   free  of  state   income   taxation   based  on  ERT's
          qualification as a real estate  investment trust and EBTC's ability to
          exclude  95%  of  all  dividends  received  by it  from  subsidiaries,
          including   ERT,   from  state  income   taxation   under   applicable
          Massachusetts  tax law. The  retroactive  feature of the new law would
          require the Registrant to pay the additional  taxes that the DOR seeks
          to collect for all tax years from 1999 through 2002.

          The Registrant believes that it has complied fully with the applicable
          Massachusetts  tax laws in deducting 95% of the dividends  received by
          EBTC from ERT in calculating its taxable income for  Massachusetts tax
          purposes.  The  registrant  also  believes  that  ERT  is  a  properly
          qualified real estate  investment trust and, as such, owes no taxes to
          the  Commonwealth of  Massachusetts on any amounts that it has paid as
          dividends to EBTC in prior years.  Moreover,  the  Registrant has been
          advised that the  constitutionality  of the retroactive changes to the
          state's tax laws  contained  in the  recently  passed  legislation  is
          questionable.

          The  $2.3  million  one-time  income  tax  expense  referred  to above
          consists of $3.5  million of state income tax  liability,  net of $1.2
          million  in  federal  income tax  benefit.  The $3.5  million in state
          income tax liability consists of the following:

          (i)  payment to the Commonwealth of Massachusetts  of  $1.2 million as
               estimated  state  taxes due for the tax year ended  December  31,
               2002,  which amount would be refunded if the Registrant  prevails
               in its  current  dispute  with  the  DOR  and if the  retroactive
               feature of the new legislation, as it applies to 2002, is held to
               be unconstitutional; and

          (ii) a liability for state income taxes to be paid of $2.3 million for
               the tax years ended December 31, 2001, 2000 and 1999,  which will
               become payable to the  Commonwealth of  Massachusetts  if the DOR
               prevails in its current  dispute  with the  Registrant  or if the
               retroactive   feature   of   the   new   legislation   withstands
               constitutional challenge.

          In addition,  the Registrant will record,  in 2003 and for the periods
          thereafter, state income tax liability on ERT's taxable income.


                     [Remainder of Page Intentionally Blank]



                                   Signatures

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                            ENTERPRISE BANCORP, INC.



Date:  March 7, 2003                        By: /s/John P. Clancy, Jr.
                                                --------------------------------
                                                   John P. Clancy, Jr.
                                                   President and Treasurer
                                                   (Principal Financial Officer)