SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

        Date of Report (Date of Earliest Event Reported): January 3, 2005
                                                         (December 31, 2004)

                              --------------------


                            ENTERPRISE BANCORP, INC.
               (exact name of registrant as specified in charter)

Massachusetts                            0-21021             04-3308902
(State or Other Jurisdiction             (Commission         (IRS Employer
of Incorporation)                        File Number)        Identification No.)

222 Merrimack Street                                         01852
Lowell, Massachusetts                                        (Zip Code)
(address of principal executive offices)

                                 (978) 459-9000
              (Registrant's telephone number, including area code)



         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions:

         []  Written  communications  pursuant to Rule 425 under the  Securities
             Act (17 CFR 230.425)

         []  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act
             (17 CFR 240.14a-12)

         []  Pre-commencement communications pursuant to Rule 14d-2(b) under the
             Exchange Act (17 CFR 240.14d-2(b))

         []  Pre-commencement communications pursuant to Rule 13e-4(c) under the
             Exchange Act (17 CFR 240.13e-4(c))











Items 1.01, 5.02 and 8.01.  Entry into a Material Definitive Agreement
                            Departure of Directors or Principal Officers;
                            Election of Directors; Appointment of Principal
                            Officers
                            Other Events

                  The registrant's  board of directors  approved certain changes
         in title with respect to two of the  registrant's  executive  officers.
         These changes became effective on December 31, 2004.

                  The changes are as follows:

                    o    Richard  W.  Main has  relinquished  his title as Chief
                         Operating   Officer  of  the   registrant's   principal
                         subsidiary,  Enterprise  Bank and  Trust  Company  (the
                         "Bank"),  and  has  been  appointed  President  of  the
                         registrant.  Mr.  Main now serves as  President  of the
                         registrant  and President and Chief Lending  Officer of
                         the Bank.

                    o    John P.  Clancy,  Jr.  has  relinquished  his titles as
                         President and Treasurer of the registrant and Treasurer
                         of the  Bank.  He has  been  appointed  Executive  Vice
                         President   and   Chief   Operating   Officer   of  the
                         registrant,  and, in addition to being  Executive  Vice
                         President  of the  Bank,  he has been  appointed  Chief
                         Operating Officer of the Bank. Mr. Clancy now serves as
                         Executive Vice President and Chief Operating Officer of
                         the registrant and the Bank.

                  Additional  information  regarding Messrs.  Main and Clancy is
         included in the registrant's proxy statement for its most recent annual
         meeting of stockholders, which was held on May 4, 2004.

                  Each of Messrs.  Main and Clancy  consented  to the changes in
         his  title for  purposes  of  Section  1.7 of his  existing  employment
         agreement  and each of them  entered  into an amendment to his existing
         employment  agreement to reflect these  changes.  No other changes have
         been made to the  existing  employment  agreement of either Mr. Main or
         Mr. Clancy.  Copies of the  amendments to the employment  agreements of
         Messrs. Main and Clancy are included with this report.

                  In  addition  to  the  changes  in  executive  officer  titles
         described  above,  James A. Marcotte,  who previously  served as Senior
         Vice  President and Chief  Financial  Officer of the registrant and the
         Bank,  has  been  appointed  to  serve  as  Executive  Vice  President,
         Treasurer and Chief  Financial  Officer of the registrant and the Bank,
         and  Stephen  J.  Irish,  who  previously   served  as  Executive  Vice
         President,  Chief Information  Officer and Chief Operations  Officer of
         the Bank, has relinquished  his title as Chief  Operations  Officer and
         now serves as Executive Vice President and Chief Information Officer of
         the Bank.


Item 9.01.        Financial Statements and Exhibits

    (a)  Not applicable

    (b)  Not applicable

    (c)  The following exhibits are included with this report:

         Exhibit 10.34  Amendment No. 1 dated as of December 31, 2004 to Amended
                        and Restated Employment Agreement dated January 1, 2004
                        by and among the registrant, the Bank and Richard W.
                        Main.

         Exhibit 10.35  Amendment  No.  1  dated  as of  December 31,  2004  to
                        Employment Agreement dated April 1, 2004 by and among
                        the registrant, the Bank and John P. Clancy, Jr.








                     [Remainder of Page Intentionally Blank]







                                   Signatures

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                      ENTERPRISE BANCORP, INC.



Date:  January 3, 2005                By:  /s/ James A. Marcotte
                                          --------------------------------------
                                           James A. Marcotte
                                           Executive Vice President, Treasurer
                                           and Chief Financial Officer