SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549
                                               
                            -------------------


                                  FORM 8-A
             FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                 PURSUANT TO SECTION 12(b) OR 12(g) OF THE
                      SECURITIES EXCHANGE ACT OF 1934
                                            
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                           U.S. BIOSCIENCE, INC.
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           (Exact Name of Registrant as Specified in its Charter)

           Delaware                                    23-2460100
- ------------------------------               ------------------------------
    (State of Incorporation                         (I.R.S. Employer
       or Organization)                            Identification No.)

               One Tower Bridge
               100 Front Street
       West Conshohocken, Pennsylvania                         14428
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       (Address and Telephone Number of                     (Zip Code)
         Principal Executive Offices)


If this Form relates to the registration of a class of debt securities and
is effective upon filing pursuant to General Instruction A(c)(1) please
check the following box. [_]

If this Form relates to the registration of a class of debt securities and
is to become effective simultaneously with the effectiveness of a
concurrent registration statement under the Securities Act of 1933 pursuant
to General Instruction A(c)(2) please check the following box. [_]

     Securities to be registered pursuant to Section 12(b) of the Act:


      Title of Each Class                    Name of Each Exchange on Which
      to be so Registered                    Each Class is to be Registered
- ------------------------------               ------------------------------

Preferred Stock Purchase                     American Stock Exchange
Rights                                       ("AMEX")


     Securities to be registered pursuant to Section 12(g) of the Act:

                                    None
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                              (Title of Class)






Item 1.  Description of Securities to be Registered.
         ------------------------------------------

          On May 19, 1995, the Board of Directors of the Company declared a
dividend of one Preferred Stock Purchase Right (the "Right(s)") for each
outstanding share of Common Stock, par value $0.005 per share (the "Common
Stock"), of the Company.  The dividend is payable as of May 29, 1995 to
stockholders of record on that date.  Each Right entitles the registered
holder to purchase from the Company one one-hundredth (1/100) of a share of
a new series of preferred shares of the Company, designated as Series A
Junior Preferred Stock ("Preferred Stock"), at a price of $15 per one
one-hundredth (1/100) of a share (the "Exercise Price"), subject to certain
adjustments.  The description and terms of the Rights are set forth in a
Rights Agreement, dated as of May 19, 1995, (the "Rights Agreement"),
between the Company and Chemical Mellon Shareholder Services L.L.C., as
Rights Agent ("Rights Agent").

          Initially the Rights will not be exercisable, certificates will
not be sent to stockholders, and the Rights will automatically trade with
the Common Stock.

          The Rights, unless earlier redeemed by the Board of Directors,
become exercisable upon the close of business on the day (the "Distribution
Date") which is the earlier of (i) the tenth day following a public
announcement that a person or group of affiliated or associated persons,
with certain exceptions set forth below, has acquired beneficial ownership
of 15% or more of the outstanding voting stock of the Company (an
"Acquiring Person") and (ii) the tenth business day (or such later date as
may be determined by the Board of Directors prior to such time as any
person or group of affiliated or associated persons becomes an Acquiring
Person) after the date of the commencement or announcement of a person's or
group's intention to commence a tender or exchange offer the consummation
of which would result in the ownership of 30% or more of the Company's





outstanding voting stock (even if no shares are actually purchased pursuant
to such offer); prior thereto, the Rights would not be exercisable, would
not be represented by a separate certificate, and would not be transferable
apart from the Company's Common Stock, but will instead be evidenced, with
respect to any of the Common Stock certificates outstanding as of May 29,
1995, by such Common Stock certificate with a copy of this Summary of
Rights attached thereto.  An Acquiring Person does not include (A) the
Company, (B) any subsidiary of the Company, (C) any employee benefit plan
or employee stock plan of the Company or of any subsidiary of the Company,
or any trust or other entity organized, appointed, established or holding
Common Stock for or pursuant to the terms of any such plan or (D) any
person or group whose ownership of 15% or more of the shares of voting
stock of the Company then outstanding results solely from (i) any action or
transaction or transactions approved by the Board of Directors before such
person or group became an Acquiring Person or (ii) a reduction in the
number of issued and outstanding shares of voting stock of the Company
pursuant to a transaction or transactions approved by the Board of
Directors (provided that any person or group that does not become an
Acquiring Person by reason of clause (i) or (ii) above shall become an
Acquiring Person upon acquisition of an additional 1% of the Company's
voting stock unless such acquisition of additional voting stock will not
result in such person or group becoming an Acquiring Person by reason of
such clause (i) or (ii)). 

          Until the Distribution Date (or earlier redemption or expiration
of the Rights), new Common Stock certificates issued after May 29, 1995
will contain a legend incorporating the Rights Agreement by reference. 
Until the Distribution Date (or earlier redemption or expiration of the
Rights), the surrender for transfer of any of the Company's Common Stock
certificates outstanding as of May 29, 1995 with or without a copy of the





Summary of Rights attached, will also constitute the transfer of the Rights
associated with the Common Stock represented by such certificate.  As soon
as practicable following the Distribution Date, separate certificates
evidencing the Rights ("Right Certificates") will be mailed to holders of
record of the Company's Common Stock as of the close of business on the
Distribution Date and such separate certificates alone will evidence the
Rights from and after the Distribution Date.

          The Rights are not exercisable until the Distribution Date.  The
Rights will expire at the close of business on May 19, 2005, unless earlier
redeemed by the Company as described below.

          The Preferred Stock is non-redeemable and, unless otherwise
provided in connection with the creation of a subsequent series of
preferred stock, subordinate to any other series of the Company's preferred
stock.  The Preferred Stock may not be issued except upon exercise of
Rights.  Each share of Preferred Stock will be entitled to receive when, as
and if declared, a quarterly dividend in an amount equal to the greater of
$1.00 per share and 100 times the cash dividends declared on the Company's
Common Stock.  In addition, the Preferred Stock is entitled to 100 times
any non-cash dividends (other than dividends payable in equity securities)
declared on the Common Stock, in like kind.  In the event of liquidation,
the holders of Preferred Stock will be entitled to receive for each share
of Series A Preferred Stock, a liquidation payment in an amount equal to
the greater of $1,500 or 100 times the payment made per share of Common
Stock.  Each share of Preferred Stock will have 100 votes, voting together
with the Common Stock.  In the event of any merger, consolidation or other
transaction in which Common Stock is exchanged, each share of Preferred
Stock will be entitled to receive 100 times the amount received per share
of Common Stock.  The rights of Preferred Stock as to dividends,
liquidation and voting are protected by anti-dilution provisions.





          The number of shares of Preferred Stock issuable upon exercise of
the Rights is subject to certain adjustments from time to time in the event
of a stock dividend on, or a subdivision or combination of, the Common
Stock.  The Exercise Price for the Rights is subject to adjustment in the
event of extraordinary distributions of cash or other property to holders
of Common Stock.

          Unless the Rights are earlier redeemed or the transaction is
approved by the Board of Directors and the Continuing Directors, in the
event that, after the time that the Rights become exercisable, the Company
were to be acquired in a merger or other business combination (in which any
shares of the Company's Common Stock are changed into or exchanged for
other securities or assets) or more than 50% of the assets or earning power
of the Company and its subsidiaries (taken as a whole) were to be sold or
transferred in one or a series of related transactions, the Rights
Agreement provides that proper provision will be made so that each holder
of record of a Right will from and after such date have the right to
receive, upon payment of the Exercise Price, that number of shares of
common stock of the acquiring company having a market value at the time of
such transaction equal to two times the Exercise Price.  In addition,
unless the Rights are earlier redeemed, if a person or group (with certain
exceptions) becomes the beneficial owner of 15% or more of the Company's
voting stock (other than pursuant to a tender or exchange offer (a
"Qualifying Tender Offer") for all outstanding shares of Common Stock that
is approved by the Board of Directors, after taking into account the long-
term value of the Company and all other factors they consider relevant in
the circumstances), the Rights Agreement provides that proper provision
will be made so that each holder of record of a Right, other than the
Acquiring Person (whose Rights will thereupon become null and void), will
thereafter have the right to receive, upon payment of the Exercise Price,





that number of shares of the Company's Preferred Stock having a market
value at the time of the transaction equal to two times the Exercise Price
(such market value to be determined with reference to the market value of
the Company's Common Stock as provided in the Rights Agreement).

          Fractions of shares of Preferred Stock (other than fractions that
are integral multiples of one one-hundredth (1/100) of a share) may, at the
election of the Company, be evidenced by depositary receipts.  The Company
may also issue cash in lieu of fractional shares which are not integral
multiples of one one-hundredth (1/100) of a share.

          At any time on or prior to the close of business on the tenth day
after the time that a person has become an Acquiring Person (or such later
date as a majority of the Board of Directors and a majority of the
Continuing Directors (as defined in the Rights Agreement) may determine),
the Company may redeem the Rights in whole, but not in part, at a price of
$.001 per Right ("Redemption Price").  The Rights may be redeemed after the
time that any Person has become an Acquiring Person only if approved by a
majority of the Continuing Directors.  Immediately upon the effective time
of the action of the Board of Directors of the Company authorizing
redemption of the Rights, the right to exercise the Rights will terminate
and the only right of the holders of the Rights will be to receive the
Redemption Price.

          For as long as the Rights are then redeemable, the Company may,
except with respect to the redemption price or date of expiration of the
Rights, amend the Rights in any manner, including an amendment to extend
the time period in which the Rights may be redeemed.  At any time when the
Rights are not then redeemable, the Company may amend the Rights in any
manner that does not materially adversely affect the interests of holders
of the Rights as such.  Amendments to the Rights Agreement from and after
the time that any Person becomes an Acquiring Person requires the approval





of a majority of the Continuing Directors (as provided in the Rights
Agreement).

          Until a Right is exercised, the holder, as such, will have no
rights as a stockholder of the Company, including, without limitation, the
right to vote or to receive dividends.

          As of March 15, 1995 there were 40,770,780 shares of Common Stock
issued and outstanding (and 7,341,342 and 1,096,634 shares reserved for
issuance under the Company's existing stock option plans and warrants,
respectively).  500,000 shares of Preferred Stock have been reserved for
issuance upon exercise of the Rights.

          The Rights have certain anti-takeover effects.  The Rights will
cause substantial dilution to a person or group who attempts to acquire the
Company on terms not approved by the Company's Board of Directors.  The
Rights should not interfere with any merger or other business combination
approved by the Board since they may be redeemed by the Company at $.01 per
Right at any time until the close of business on the tenth day (or such
later date as described above) after a person or group has obtained
beneficial ownership of 15% or more of the voting stock.

          The form of Rights Agreement between the Company and Chemical
Mellon Shareholder Services, L.L.C., as rights agent, specifying the terms
of the Rights, which includes as Exhibit A the form of Summary of Rights to
Purchase Series A Junior Preferred Stock, as Exhibit B the form of Right
Certificate and as Exhibit C the form of Certificate of Designations of the
Company setting forth the terms of the Preferred Stock is incorporated 
herein by reference to the Company's Current Report on Form 8-K dated
the date hereof.  The foregoing description of the Rights is qualified
by reference to such exhibits.






Item 2.  Exhibits.
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          1.   Rights Agreement dated as of May 19, 1995 between U.S.
               Bioscience, Inc.and Chemical Mellon Shareholder Services
               L.L.C. as Rights Agent (Incorporated by reference to the
               Company's Form 8-K, dated May 19, 1995).

          2.   Letter to Stockholders, dated June 7, 1995.






                                 SIGNATURES
                                 ----------

          Pursuant to the requirements of Section 12 of the Securities
Exchange Act of 1934, the registrant has duly caused this registration
statement to be signed on its behalf by the undersigned hereunto duly
authorized.
                              U.S. BIOSCIENCE, INC.

                              By: /s/ Robert I. Kriebel
                                 -----------------------------
                                 Name: Robert I. Kriebel  
                                 Title:  Senior Vice President
                                         


June 7, 1995





                               EXHIBIT INDEX


Exhibit No.         Description                                        Page
- ----------          -----------                                        ----

     1.        Rights Agreement dated as of May 19, 1995 between U.S.
               Bioscience, Inc. and Chemical Mellon Shareholder
               Services L.L.C. as Rights Agent (Incorporated by
               reference to the Company's Form 8-K, dated May 19,
               1995).

     2.        Letter to Stockholders, dated June 7, 1995.