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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              ---------------------
                                    FORM 8-K

             Current Report Filed Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934


                                 Date of Report
               (Date of earliest event reported): February 7, 2000


                          ENERGY BIOSYSTEMS CORPORATION
             (Exact name of registrant as specified in its charter)



                                                                           

               Delaware                                0-21130                                04-3078857


    (State or other jurisdiction of            (Commission File Number)          (I.R.S. Employer Identification No.)
    incorporation or organization)



                           4200 Research Forest Drive
                           The Woodlands, Texas 77381
                              (Address of principal
                                executive offices
                                  and zip code)


                                 (281) 364-6100
                         (Registrant's telephone number,
                              including area code)
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ITEM 5. OTHER EVENTS

         On February 7, 2000,  Energy  BioSystems  Corporation  (the  "Company")
issued a press release  announcing that it has completed the  demonstration of a
new, proprietary gene shuffling technology. Gene shuffling is a method to create
a new,  proprietary  genes  coding for enzymes  with  improved  properties.  The
Company  has  successfully  applied  the  technology  to its  biodesulfurization
development  efforts and is now exploring  opportunities  for the  technology in
areas beyond biorefining including the chemical, pharmaceutical and agricultural
biotechnology sectors.

         The press release is filed as an exhibit to this Current Report on Form
8-K and is incorporated by reference herein.

ITEM 7.  EXHIBITS

         Exhibit 99.1      -- Press Release







                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            ENERGY BIOSYSTEMS CORPORATION

Date: February 7, 2000

                                            By:   /s/ Paul G. Brown, III
                                                  ------------------------
                                                  Paul G. Brown, III
                                                  Vice President, Finance and
                                                    Administration and Chief
                                                    Financial Officer