ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 Statement Regarding Computation of Per Share Earnings The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Quarter Ended June 30, 1995: 5,232,463 53 277,320,513 5,233,599 38 198,876,743 91 476,197,256 /91 5,291,081 (1,943,000) (0.37) Six Months Ended June 30, 1995: 5,202,476 2 10,404,951 5,214,976 2 10,429,951 5,221,604 82 428,171,528 5,232,463 4 20,929,850 5,232,463 53 277,320,513 5,233,599 38 198,876,743 181 946,133,536 /181 5,227,257 (3,952,000) (0.76) Quarter Ended June 30, 1996: 10,847,725 5 54,238,623 10,848,023 7 75,936,158 10,849,767 3 32,549,301 10,851,626 1 10,851,626 10,858,605 2 21,717,209 10,862,095 1 10,862,095 10,962,004 4 43,848,014 10,962,593 2 21,925,185 10,965,241 1 10,965,241 10,965,939 6 65,795,631 10,967,993 5 54,839,963 10,972,354 2 21,944,708 10,977,354 7 76,841,478 10,978,310 4 43,913,240 10,983,980 1 10,983,980 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 6 83,976,459 13,996,949 1 13,996,949 14,446,949 5 72,234,745 14,453,492 5 72,267,460 14,456,109 1 14,456,109 14,465,806 2 28,931,612 14,472,786 1 14,472,786 14,473,658 3 43,420,974 14,478,658 1 14,478,658 14,481,500 3 43,444,499 14,483,680 1 14,483,680 14,484,059 2 28,968,118 14,485,899 3 43,457,696 14,488,079 3 43,464,237 14,526,802 1 14,526,802 91 1,128,775,033 /91 12,404,121 (2,327,000) (0.19) Continued WOD01:1996.1 ARONEX PHARMACEUTICALS, INC. Exhibit 11.1 Contnued Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Six Months Ended June 30, 1996: 10,847,725 1 10,847,725 10,848,023 5 54,240,113 10,849,767 7 75,948,369 10,851,626 3 32,554,877 10,858,605 1 10,858,605 10,862,095 2 21,724,189 10,962,004 1 10,962,004 10,962,593 4 43,850,370 10,965,241 2 21,930,482 10,965,939 1 10,965,939 10,967,993 6 65,807,955 10,927,354 5 54,861,770 10,977,354 2 21,954,708 10,978,310 7 76,848,170 10,983,980 4 43,935,920 10,989,215 1 10,989,215 13,992,587 1 13,992,587 13,996,077 1 13,996,077 13,996,949 6 83,981,694 14,446,949 1 14,446,949 14,453,492 5 72,267,460 14,456,109 5 72,280,545 14,465,806 1 14,465,806 14,472,786 2 28,945,571 14,473,658 1 14,473,658 14,478,658 3 43,435,974 14,481,500 1 14,481,500 14,483,680 3 43,451,040 14,484,059 1 14,484,059 14,485,899 2 28,971,797 14,488,079 3 43,464,237 14,526,802 3 43,580,405 10,380,056 1 10,380,056 10,390,003 10 103,900,030 10,409,608 4 41,638,432 10,418,676 2 20,837,351 10,478,786 1 10,478,786 10,046,458 3 30,139,374 10,598,792 1 10,598,792 10,678,561 2 21,357,121 10,680,653 1 10,680,653 10,680,903 3 32,042,709 10,710,132 4 42,840,526 10,718,504 6 64,311,024 10,727,170 4 42,908,678 10,728,565 1 10,728,565 10,729,263 1 10,729,263 10,729,394 7 75,105,758 10,731,487 19 203,898,253 10,742,559 7 75,197,913 10,771,115 2 21,542,230 10,775,477 2 21,550,954 10,776,991 4 43,107,962 10,784,842 1 10,784,842 10,812,921 1 10,812,921 10,832,546 2 21,665,092 10,847,725 2 21,695,449 182 2,097,932,497 /182 11,527,102 (4,400,000)(0.38)