EXHIBIT 99.1
 
                          ARONEX PHARMACEUTICALS, INC.
                     1993 AMENDED AND RESTATED NON-EMPLOYEE
                           DIRECTOR STOCK OPTION PLAN


     Aronex Pharmaceuticals, Inc., a Delaware Corporation (the "Company") hereby
amends and  restates  its 1993  Non-Employee  Director  Stock  Option Plan (this
"Plan"), effective as of November 4, 1995, subject to stockholder approval.

          1. PURPOSE.

          The purpose of this Plan is to promote and  advance the  interests  of
the  Company  by aiding  the  Company  in  attracting  and  retaining  qualified
directors of the Company who, at the time of their service, are not employees of
the  Company  or any  of its  subsidiaries  ("Non-Employee  Directors"),  and to
further  align  the  interests  of such  Non-Employee  Directors  with  those of
stockholders  through stock  options.  An additional  purpose of this Plan is to
recognize  and  reward  the  contributions  of  Non-Employee  Directors  who are
actively  involved in aspects of the  Company's  business  beyond  their role as
directors.

          2. ADMINISTRATION.

          This Plan shall be administered by the  Compensation  Committee of the
Board of Directors of the Company (the "Committee"),  which shall consist of not
less  than  two  members  of the  Board  of  Directors,  each of whom  will be a
"disinterested  person"  within the meaning of Rule 16b-3 of the  Securities and
Exchange Commission (or any successor rule to the same effect) as in effect from
time to time and an "outside  director"  within the meaning of Section 162(m) of
the Internal Revenue Code of 1986, as amended.  For the purposes of this Plan, a
majority  of the  members of the  Committee  shall  constitute  a quorum for the
transaction of business,  and the vote of a majority of those members present at
any meeting shall decide any question brought before that meeting.  No member of
the Committee shall be liable for any act or omission of any other member of the
Committee  or for  any  act or  omission  on his own  part,  including  (without
limitation)  the  exercise  of any power or  discretion  given to him under this
Plan,   except  those  resulting  from  his  own  gross  negligence  or  willful
misconduct.  All questions of interpretation and application of this Plan, or as
to  options  granted  hereunder  (the  "Options"),   shall  be  subject  to  the
determination,  which  shall be final and  binding,  of a majority  of the whole
Committee.

          3. OPTION SHARES.

          The stock  subject to the  Options and other  provisions  of this Plan
shall be shares of the Company's  Common  Stock,  par value $.001 per share (the
"Common  Stock").  The total  amount of the Common  Stock with  respect to which
Options  may be  granted  shall not  exceed  600,000  shares  in the  aggregate;
provided,  that the class and aggregate number of shares which may be subject to
the Options granted  hereunder shall be subject to adjustment in accordance with
the provisions of Section 11 of this Plan. Such shares may be treasury shares or
authorized but unissued shares.

          If any outstanding  Option for any reason shall expire or terminate by
reason of the death of the optionee or the fact that the optionee ceases to be a
director,  the surrender of any such Option,  or any other cause,  the shares of
Common Stock  allocable to the  unexercised  portion of such Option may again be
subject to an Option under this Plan.






          4. GRANT OF OPTIONS.

          a. Formula Grants.

          i. Directors on the Effective Date of the Amendment and Restatement of
     this Plan.  Subject to the provisions of Section 15 hereof,  there shall be
     granted to each person who is a Non-Employee  Director,  upon the effective
     date of the amendment and  restatement  of this Plan, an Option to purchase
     25,000  shares of the Common Stock at a per share Option Price equal to the
     fair market value (as defined in Subsection  4(a)(iv)  below) of a share of
     Common Stock on such date.

          ii.  Directors  Elected after the Effective  Date of the Amendment and
     Restatement  of this Plan.  Subject to the provisions of Section 15 hereof,
     for so long as this Plan is in effect  and  shares  are  available  for the
     grant of Options hereunder, each person who is not otherwise an employee of
     the Company,  and who is first elected to the Board of Directors  after the
     effective  date of the amendment  and  restatement  of this Plan,  shall be
     granted,  on the date of his election,  an Option to purchase 25,000 shares
     of Common  Stock (such number of shares  being  subject to the  adjustments
     provided in Section 11 of this Plan) at a per share  Option  Price equal to
     the fair market value of a share of Common Stock on such date.

          iii.  Annual Grants.  On December 31 of each year that this Plan is in
     effect (commencing with December 31, 1996), each Non-Employee  Director who
     is in office on that day  (provided  that such  Non-Employee  Director  has
     served as a  director  for at least six months  prior to such  date)  shall
     automatically  receive an Option to purchase  7,500  shares of Common Stock
     (such number of shares being subject to the adjustments provided in Section
     11 of this Plan) at a per share Option Price equal to the fair market value
     of a share of Common Stock on such date.

          iv.  Fair Market  Value.  For  purposes  of this  Section 4, the "fair
     market  value" of a share of Common Stock as of any  particular  date shall
     mean (i) if the  Common  Stock is  listed or  admitted  to  trading  on any
     securities  exchange or on the National  Association of Securities  Dealers
     (the "NASD")  Automated  Quotation System ("Nasdaq")  National Market,  the
     closing  price on such day on the principal  securities  exchange or on the
     Nasdaq National Market on which the Common Stock is traded or quoted, or if
     such day is not a trading  day for such  securities  exchange or the Nasdaq
     National  Market,  the closing price on the first  preceding day that was a
     trading  day,  (ii) if the Common  Stock is not then  listed or admitted to
     trading on any securities  exchange or on the Nasdaq National  Market,  the
     closing bid price on such day as reported by the NASD,  or if no such price
     is reported by the NASD for such day,  the closing bid price as reported by
     the NASD on the first preceding day for which such price is available,  and
     (iii) if the Common  Stock is not then listed or admitted to trading on any
     securities  exchange or on the Nasdaq  National  Market and no such closing
     bid price is reported by the NASD,  as  determined by the Committee in good
     faith.

          v. No  Discretion  with Respect to Formula  Grants.  The  selection of
     Non-Employee  Directors to whom Options are to be granted  pursuant to this
     Section 4(a), the number of shares subject to any such Option, the exercise
     price  of any such  Option  and the  term of any  such  Option  shall be as
     provided  herein  and the  Committee  shall have no  discretion  as to such
     matters.

          b. Discretionary Grants. The Committee may from time to time authorize
grants to any Non-Employee  Director (provided that no such grant may be made to
a Non-Employee Director who is a member of the Committee, and that no such grant
may be made that would  prevent the members of the Committee  from  constituting
"disinterested persons" within the meaning of Rule 16b-3) of Options to purchase
shares of Common  Stock upon such terms and  conditions  as it may  determine in
accordance with the following provisions:


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          i. Each grant  will  specify  the number of shares of Common  Stock to
     which the Option granted pertains.

          ii. Each grant will specify the Option Price of the Option,  which may
     be less than,  equal to or greater than the fair market value of a share of
     Common Stock on the date of grant.

          iii.  Each  grant  may  specify  the  required  period or  periods  of
     continuous  service  by the  grantee  with the  Company  and/or  the  other
     conditions  of vesting (if any) before the Option or  installments  thereof
     will become exercisable.

          c.  Outstanding  Options.  The amendment and  restatement of this Plan
shall not  affect  the terms and  conditions  of any  Options  (including  terms
relating  to the vesting and term  thereof)  outstanding  under this Plan on the
effective date of such amendment and restatement.

          5. VESTING AND TERM OF OPTIONS.

          Each Option granted under Section 4(a) of this Plan shall vest in full
and be  exercisable to purchase all of the shares of Common Stock subject to the
Option on the date on which the  Option was  granted,  and each  Option  granted
under  Section 4(b) of this Plan shall vest and be  exercisable  to purchase the
number of shares subject to the Option at such times and upon such conditions as
may be established  by the Committee on the date of grant,  subject in each case
to earlier  termination  as  provided  in Section 8 of this  Plan.  Each  Option
granted  under this Plan shall  expire on the tenth  anniversary  of the date on
which the Option was granted.

          6. EXERCISE OF OPTIONS.

          An optionee  may exercise  his Option by  delivering  to the Company a
written notice stating (a) that such optionee  wishes to exercise such Option on
the date such notice is so  delivered,  (b) the number of shares of Common Stock
with  respect to which such  Option is to be  exercised  and (c) the  address to
which the certificate  representing such shares of stock should be mailed. To be
effective,  such written  notice shall be  accompanied  by payment of the Option
Price of each of such shares of Common Stock. Each such payment shall be made by
cash,  cashier's check or bank draft drawn on a national banking  association or
postal or express  money  order,  payable to the order of the  Company in United
States dollars.

          Any Option granted under the Plan may be exercised by a  broker-dealer
acting on behalf of an optionee if (i) the  broker-dealer  has received from the
optionee or the Company a duly  endorsed  agreement  evidencing  such Option and
instructions signed by the optionee requesting the Company to deliver the shares
of Common  Stock  subject to such Option to the  broker-dealer  on behalf of the
Participant  and  specifying  the  account  into  which  such  shares  should be
deposited,  (ii) adequate provision has been made with respect to the payment of
any withholding  taxes due on such exercise and (iii) the  broker-dealer and the
optionee have  otherwise  complied with Section  220.3(e)(4) of Regulation T, 12
CFR Part 220.

          As promptly as  practicable  after the receipt by the Company,  in the
form required by the foregoing provisions of this Section 6, of (a) such written
notice from the optionee  and (b) payment,  of the Option Price of the shares of
stock with respect to which such Option is to be  exercised,  the Company  shall
deliver to such  optionee  a  certificate  representing  the number of shares of
stock with respect to which such Option has been so exercised  registered in the
name of such  optionee,  provided that such delivery shall be considered to have
been made when such certificate shall have been mailed, postage prepaid, to such
optionee at the address  specified for such purpose in such written  notice from
the optionee to the Company.


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          7. TRANSFERABILITY OF OPTIONS.

          Options shall not be  transferable  by the optionee  otherwise than by
will or under the laws of descent and distribution.

          8. TERMINATION.

          Except  as may  be  otherwise  expressly  provided  in  this  Plan  or
otherwise  determined by the Committee,  each Option, to the extent it shall not
have  been  exercised  previously,  shall  terminate  on  the  earliest  of  the
following:

          (a) On the last day of the 24 month period  commencing  on the date on
     which  the  optionee  ceases  to be a  member  of the  Company's  Board  of
     Directors,  for any  reason  other than the death of the  optionee,  during
     which period the optionee shall be entitled to exercise all Options held by
     the optionee on the date on which the optionee ceased to be a member of the
     Company's Board of Directors which could have been exercised on such date;

          (b) On the last day of the six-month period  commencing on the date of
     the  optionee's  death while serving as a member of the Company's  Board of
     Directors,  during  which  period  the  executor  or  administrator  of the
     optionee's  estate or the person or persons to whom the  optionee's  Option
     shall have been transferred by will or the laws of descent or distribution,
     shall be  entitled  to  exercise  all  Options  in respect of the number of
     shares that the  optionee  would have been  entitled  to  purchase  had the
     optionee exercised such Options on the date of his death; or

          (c) Ten years after the date of grant of such Option.

          9. REQUIREMENTS OF LAW.

          The Company  shall not be  required to sell or issue any shares  under
any Option if the  issuance of such shares  shall  constitute a violation by the
optionee  or the  Company  of any  provisions  of any law or  regulation  of any
governmental authority.  Each Option granted under this Plan shall be subject to
the  requirement  that,  if at any time the Board of Directors of the Company or
the  Committee   shall   determine  that  (i)  the  listing,   registration   or
qualification  of the shares  subject  thereto upon any  securities  exchange or
under any state or federal law of the United  States or of any other  country or
governmental   subdivision  thereof,   (ii)  the  consent  or  approval  of  any
governmental  regulatory  body,  or (iii)  the  making  of  investment  or other
representations,  are  necessary or desirable  in  connection  with the issue or
purchase of shares subject thereto,  no such Option may be exercised in whole or
in part unless such listing, registration,  qualification,  consent, approval or
representation  shall have been effected or obtained free of any  conditions not
acceptable to the Board of Directors.  Any  determination  in this connection by
the Committee shall be final, binding and conclusive.  If the shares issuable on
exercise of an Option are not  registered  under the Securities Act of 1933, the
Company may imprint on the certificate  for such shares the following  legend or
any legend  which  counsel for the Company  considers  necessary or advisable to
comply with the Securities Act of 1933:

     THE  SHARES OF STOCK  REPRESENTED  BY THIS  CERTIFICATE  HAVE NOT BEEN
     REGISTERED  UNDER THE  SECURITIES  ACT OF 1933 OR UNDER THE SECURITIES
     LAWS OF ANY STATE AND MAY NOT BE SOLD OR TRANSFERRED  EXCEPT UPON SUCH
     REGISTRATION  OR UPON  RECEIPT  BY THE  CORPORATION  OF AN  OPINION OF
     COUNSEL  SATISFACTORY  TO  THE  CORPORATION,  IN  FORM  AND  SUBSTANCE
     SATISFACTORY TO THE CORPORATION, THAT REGISTRATION IS NOT REQUIRED FOR
     SUCH SALE OR TRANSFER.



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     The  Company  may,  but shall in no event be  obligated  to,  register  any
securities  covered  hereby  pursuant to the  Securities  Act of 1933 (as now in
effect or as  hereinafter  amended)  and, if any shares are so  registered,  the
Company may remove any legend on  certificates  representing  such  shares.  The
Company shall not be obligated to take any other affirmative action to cause the
exercise of an Option or the issuance of shares pursuant  thereto to comply with
any law or regulation or any governmental authority.

          10. NO RIGHTS AS STOCKHOLDER.

          No optionee shall have rights as a stockholder  with respect to shares
covered by his Option until the date of issuance of a stock certificate for such
shares;  and, except as otherwise  provided in Section 11 hereof,  no adjustment
for dividends, or otherwise,  shall be made if the record date therefor is prior
to the date of issuance of such certificate.

          11. CHANGES IN THE COMPANY'S CAPITAL STRUCTURE.

          The existence of  outstanding  Options shall not affect in any way the
right or power of the Company or its  stockholders  to make or authorize  any of
all  adjustments,  recapitalizations,  reorganizations  or other  changes in the
Company's  capital  structure or its business or any merger or  consolidation of
the Company,  or any issue of bonds,  debentures,  preferred or prior preference
stock  ahead of or  affecting  the Common  Stock or the rights  thereof,  or the
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its  assets or  business,  or any  other  corporate  act or  proceeding,
whether of a similar character or otherwise.

          If the Company shall effect a subdivision or  consolidation  of shares
or other capital readjustment, the payment of a stock dividend or other increase
or reduction of the number of shares of the Common  Stock  outstanding,  without
receiving  consideration  therefor in money, services or property,  then (a) the
number,  class and per share  price of shares of stock  subject  to  outstanding
Options hereunder shall be appropriately adjusted in such a manner as to entitle
an optionee to receive upon exercise of an Option,  for the same  aggregate cash
consideration,  the same total number and class or classes of shares as he would
have received had he exercised his Option in full immediately prior to the event
requiring the  adjustment;  and (b) the number and class of shares then reserved
for  issuance  under  this Plan and the  number of shares to be  subject  to the
grants to be made  pursuant to Section  4(a)(ii)  and (iii) shall be adjusted by
substituting  for the total number and class of shares of stock then reserved or
subject  to grant the  number and class or classes or shares of stock that would
have been  received  by the owner of an equal  number of  outstanding  shares of
Common Stock as the result of the event requiring the  adjustment,  disregarding
any fractional shares.

          If the  Company  merges  or  consolidates  with  another  corporation,
whether or not the  Company is a  surviving  corporation,  or if the  Company is
liquidated  or sells or otherwise  disposes of  substantially  all of its assets
while unexercised Options remain outstanding under this Plan, or if any "person"
(as that term is used in Section 13(d) and 14(d)(2) of the  Securities  Exchange
Act of 1934) is or becomes the  beneficial  owner,  directly or  indirectly,  of
securities of the Company  representing  greater than 50% of the combined voting
power of the Company's then outstanding securities,  after the effective date of
such merger, consolidation,  liquidation, sale or other disposition, as the case
may be, each holder of an outstanding Option shall be entitled, upon exercise of
such Option, to receive, in lieu of shares of Common Stock, the number and class
or classes of shares of such stock or other securities or property to which such
holder  would  have  been  entitled  if,   immediately  prior  to  such  merger,
consolidation,  liquidation, sale or other disposition, such holder had been the
holder of record of a number of shares of Common  Stock  equal to the  number of
shares as to which such Option may be exercised.

          Except as otherwise  expressly provided in this Plan, the issue by the
Company of shares of stock of any class, or securities  convertible  into shares
of stock of any class,  for cash or  property,  or for labor or services  either
upon  direct  sale or upon the  exercise  of rights  or  warrants  to  subscribe
therefor, or upon conversion of shares or obligations of the Company convertible
into such shares or other  securities,  shall not affect,  and no  adjustment by
reason  thereof  shall be made with respect to, the number or price of shares of
Common Stock then subject to outstanding Options.


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          12. AMENDMENT OR TERMINATION OF PLAN.

          The Board of Directors  may modify,  revise or terminate  this Plan at
any time and from time to time;  provided,  however,  that  without  the further
approval  of the  holders of at least a majority  of the  outstanding  shares of
voting  stock,  or if  the  provisions  of  the  corporate  charter,  bylaws  or
applicable  state law prescribes a greater  degree of  stockholder  approval for
this action, without the degree of stockholder approval thus required, the Board
of  Directors  may  not  (a)  materially   increase  the  benefits  accruing  to
participants  under this Plan; (b)  materially  increase the number of shares of
Common Stock that may be issued under this Plan;  or (c)  materially  modify the
requirements as to eligibility for  participation in this Plan,  unless, in each
such case,  the Board of Directors of the Company shall have obtained an opinion
of legal counsel to the effect that stockholder approval of the amendment is not
required (x) by law, (y) by the rules and regulations of, or any agreement with,
the National Association of Securities Dealers, Inc. or (z) to make available to
the optionee with respect to any Option  granted under this Plan the benefits of
Rule 16b-3 under the  Securities  Exchange Act of 1934 (the "1934 Act"),  or any
similar or successor  rule. In addition,  this Plan may not be amended more than
once every six months with  respect to the plan  provisions  referred to in Rule
16b-3(c)(2)(ii)(A)  under the 1934 Act other than to comport with changes in the
Internal  Revenue  Code of 1986,  as amended,  the  Employee  Retirement  Income
Security Act of 1974, as amended,  or the rules thereunder.  All Options granted
under this Plan shall be  subject to the terms and  provisions  of this Plan and
any amendment,  modification  or revision of this Plan shall be deemed to amend,
modify or revise  all  Options  outstanding  under this Plan at the time of such
amendment, modification or revision. If this Plan is terminated by action of the
Board of Directors, all outstanding Options may be terminated.

          13. WRITTEN AGREEMENT.

          Each Option  granted  hereunder  shall be embodied in a written option
agreement,  which shall be subject to the terms and conditions prescribed above,
and  shall be signed  by the  optionee  and by the  appropriate  officer  of the
Company  for and in the  name  and on  behalf  of the  Company.  Such an  option
agreement shall contain such other provisions as the Committee in its discretion
shall deem advisable.

          14. INDEMNIFICATION OF COMMITTEE AND BOARD OF DIRECTORS.

          The Company shall, to the fullest extent permitted by law,  indemnify,
defend and hold  harmless any person who at any time is a party or is threatened
to be made a party to any  threatened,  pending  or  completed  action,  suit or
proceeding (whether civil, criminal, administrative or investigative) in any way
relating  to or  arising  out of this  Plan or any  Option  or  Options  granted
hereunder  by  reason  of the  fact  that  such  person  is or was at any time a
director of the Company or a member of the Committee against  judgments,  fines,
penalties,  settlements  and reasonable  expenses  (including  attorney's  fees)
actually  incurred  by such  person  in  connection  with such  action,  suit or
proceeding.  This right of  indemnification  shall  inure to the  benefit of the
heirs,  executors and  administrators  of each such person and is in addition to
all other rights to which such person may be entitled by virtue of the bylaws of
the Company or as a matter of law, contract or otherwise.

          15. EFFECTIVE DATE OF AMENDED AND RESTATED PLAN.

          The amendment  and  restatement  of this Plan shall become  effective,
subject to  stockholder  approval,  on November  14,  1995.  The  amendment  and
restatement of this Plan, and all Options granted  pursuant to the amendment and
restatement of this Plan prior to stockholder approval,  shall be void and of no
further force and effect unless the amendment and restatement of this Plan shall
have been approved by the requisite vote of the stockholders entitled to vote at
a meeting of the  stockholders  of the Company  called for such purpose prior to
July 30, 1996. In the event such stockholder approval is not obtained, this Plan
shall continue in existence with the terms and conditions in effect prior to the
effective date of the amendment and restatement  provided for hereby.  No Option
shall be granted pursuant to this Plan on or after September 30, 2003.


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