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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                    FORM 8-K

             Current Report Filed Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934


                                 Date of Report
              (Date of earliest event reported): September 13, 1999


                                  ZONAGEN, INC.
             (Exact name of registrant as specified in its charter)


                                                                        

               Delaware                                0-21198                                76-0233274
    (State or other jurisdiction of            (Commission File Number)          (I.R.S. Employer Identification No.)
    incorporation or organization)


                        2408 Timberloch Place, Suite B-4
                           The Woodlands, Texas 77380
                              (Address of principal
                                executive offices
                                  and zip code)
                                 (281) 719-3400
                         (Registrant's telephone number,
                              including area code)

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Item 5. Other Events

         On September 13, 1999, Zonagen,  Inc. issued a press release announcing
the focus of its  resources  on its lead product  candidates  -  Vasomax(R)  and
Vasofem(TM).   The  action  will  result  in  the  dismissal  of  15  employees,
representing a reduction of approximately one-third of the Company's work force.

         The press release is filed as an exhibit to this Current Report on Form
8-K and is incorporated by reference herein.

Item 7.  Exhibits

         Exhibit 99.1      -- Press Release

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                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                         ZONAGEN, INC.

Date: September 14, 1999

                                         By:      /s/ F. Scott Reding
                                             ---------------------------------
                                                  F. Scott Reding
                                                  Chief Financial Officer




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