SECURITIES AND EXCHANGE COMMISSION
                          Washington, State D.C. 20549

                                  SCHEDULE 13D

                   Under the Securities Exchange Act of 1934
                              (Amendment No. 11)*

                          Amylin Pharmaceuticals, Inc.
                                (Name of Issuer)

                         Common Stock, Par Value $.001
                         (Title of Class of Securities)

                                   032346108
                                 (CUSIP Number)

                               Marc Weitzen, Esq.
                                Icahn Capital LP
                          767 Fifth Avenue, 47th Floor
                            New York, New York 10153
                                 (212) 702-4388
          (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                January 22, 2010
            (Date of Event which Requires Filing of this Statement)

If  the filing person has previously filed a statement on Schedule 13G to report
the  acquisition  that  is  the subject of this Schedule 13D, and is filing this
schedule  because  of  Section 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the  following  box  /  /.

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to  whom  copies  are  to  be  sent.

*The  remainder  of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent  amendment  containing  information  which  would  alter
disclosures  provided  in  a  prior  cover  page.

The information required on the remainder of this cover page shall not be deemed
to  be  "filed"  for the purpose of Section 18 of the Securities Exchange Act of
1934  ("Act") or otherwise subject to the liabilities of that section of the Act
but  shall  be  subject  to  all  other  provisions of the Act (however, see the
Notes).



                                  SCHEDULE 13D
                                AMENDMENT NO. 11

Item 1. Security and Issuer

The  Schedule  13D  filed with the Securities and Exchange Commission ("SEC") by
the  Reporting  Persons  on  May  22,  2008  (as amended, the "Initial 13D"), as
amended by amendment No. 1 filed on September 12, 2009, amendment no. 2 filed on
January  29,  2009,  amendment  no. 3 filed on January 30, 2009, amendment no. 4
filed on February 5, 2009, amendment no. 5 filed on April 9, 2009, amendment no.
6  filed  on  April 16, 2009, amendment no. 7 filed on April 21, 2009, amendment
no.  8  filed  on  April  22, 2009 , amendment no. 9 filed on April 30, 2009 and
amendment  no.  10  filed on May 14, 2009 thereto, with respect to the shares of
Common  Stock, par value $.001 (the "Shares"), issued by Amylin Pharmaceuticals,
Inc.,  (the  "Issuer"),  is hereby amended to furnish the additional information
set  forth  herein.  All  capitalized  terms  contained herein but not otherwise
defined  shall  have the meanings ascribed to such terms in the Initial 13D. The
address  of  the  principal executive offices of the Issuer is 9360 Towne Centre
Drive,  San  Diego,  California  92121.

Item 4. Purpose of Transaction

Item 4 is here by amended by the addition of the following:

Recently,  representatives  of the Reporting Persons have spoken either directly
or  indirectly  with  Board members and officers of Issuer and have been assured
that  a  sufficient  number  of  Board members are in favor of, and will vote at
their  upcoming  Board  meeting  to  re-nominate  each  of  the twelve incumbent
directors,  including  Alexander  Denner and M. Kathleen Behrens, as the Board's
slate  of director nominees at the Issuer's 2010 Annual Meeting of Stockholders.
Based  upon  these  assurances  that  the  Board will nominate Dr. Denner and Ms
Behrens  and given that Reporting Persons believe that the Board of Directors is
functioning  more  satisfactorily  than  in the past, the Reporting Persons have
determined  not  to give notice of their intent to nominate persons for election
to  the  Board  of  Directors  at  the  2010  Annual  Meeting.





                                   SIGNATURE

     After  reasonable  inquiry  and  to  the  best  of  each of the undersigned
knowledge and belief, each of the undersigned certifies that the information set
forth  in  this  statement  is  true,  complete  and  correct.

Dated:  January  25,  2010


ICAHN  PARTNERS  MASTER  FUND  LP

     By:  /s/  Edward  E.  Mattner
         -------------------------
         Name:  Edward  E.  Mattner
         Title:  Authorized  Signatory

ICAHN  PARTNERS  MASTER  FUND  II  LP

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory

ICAHN  PARTNERS  MASTER  FUND  III  LP

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory

ICAHN  OFFSHORE  LP

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory

ICAHN  PARTNERS  LP

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory

ICAHN  ONSHORE  LP

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory



               [Signature Page of Schedule 13D Amendment No. 11 -
                         Amylin Pharmaceuticals, Inc.]




ICAHN  CAPITAL  LP
     By:  IPH  GP  LLC,  its  general  partner
     By:  Icahn  Enterprises  Holdings  L.P.,  its  sole  member
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner

       By:  /s/  Dominick  Ragone
            ---------------------
            Name:  Dominick  Ragone
            Title:  Chief  Financial  Officer

IPH  GP  LLC
     By:  Icahn  Enterprises  Holdings  L.P.,  its  sole  member
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner

       By:  /s/  Dominick  Ragone
            ---------------------
            Name:  Dominick  Ragone
            Title:  Chief  Financial  Officer


ICAHN  ENTERPRISES  HOLDINGS  L.P.
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner

       By:  /s/  Dominick  Ragone
            ---------------------
            Name:  Dominick  Ragone
            Title:  Chief  Financial  Officer



               [Signature Page of Schedule 13D Amendment No. 11 -
                         Amylin Pharmaceuticals, Inc.]



ICAHN  ENTERPRISES  G.P.  INC.

By:  /s/  Dominick  Ragone
     ---------------------
     Name:  Dominick  Ragone
     Title:  Chief  Financial  Officer


BECKTON  CORP.

By:  /s/  Edward  E.  Mattner
     ------------------------
     Name:  Edward  E.  Mattner
     Title:  Authorized  Signatory














               [Signature Page of Schedule 13D Amendment No. 11 -
                         Amylin Pharmaceuticals, Inc.]






Dated:  January  25,  2010










/s/ Carl C. Icahn
- -----------------
CARL  C.  ICAHN







               [Signature Page of Schedule 13D Amendment No. 11 -
                         Amylin Pharmaceuticals, Inc.]