SCHEDULE 14A
                   Proxy Statement Pursuant to Section 14(a)
             of the Securities Exchange Act of 1934 (Amendment No.)


Filed by the Registrant                     [ ]

Filed by a Party other than the Registrant  [x]

Check the appropriate box:

[X] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
[ ] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to 240.14a-12

                              GENZYME CORPORATION
                (Name of Registrant as Specified In Its Charter)

                              DR. STEPHEN BURAKOFF
                            DR. ALEXANDER J. DENNER
                               MR. CARL C. ICAHN
                              DR. RICHARD MULLIGAN
                                 DR. ERIC ENDE
                         HIGH RIVER LIMITED PARTNERSHIP
                             HOPPER INVESTMENTS LLC
                                 BARBERRY CORP.
                               ICAHN PARTNERS LP
                         ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                       ICAHN PARTNERS MASTER FUND III LP
                          ICAHN ENTERPRISES G.P. INC.
                        ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                               ICAHN OFFSHORE LP
                                 BECKTON CORP.
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act Rule 14a-6(i)(4) and 0-11.

     1)   Title  of  each  class  of  securities  to  which transaction applies:

     2)   Aggregate  number  of  securities  to  which  transaction  applies:

     3)   Per unit  price  or  other  underlying  value  of transaction computed
          pursuant  to Exchange Act Rule 0-11 (set forth the amount on which the
          filing  fee  is  calculated  and  state  how  it  was  determined):

     4)   Proposed  maximum  aggregate  value  of  transaction:

     5)   Total  fee  paid:

[ ] Fee paid previously with preliminary materials.

[ ] Check  box  if  any part of the fee is offset as provided by Exchange Act
    Rule  0-11(a)(2)  and  identify the filing for which the offsetting fee was
    paid  previously.  Identify  the  previous filing by registration statement
    number,  or  the  Form  or  Schedule  and  the  date  of  its  filing.

     1)   Amount  Previously  Paid:

     2)   Form,  Schedule  or  Registration  Statement  No.:

     3)   Filing  Party:

     4)   Date  Filed:




                  [PRELIMINARY COPIES, SUBJECT TO COMPLETION]
                      2010 ANNUAL MEETING OF SHAREHOLDERS

                                       OF

                              GENZYME CORPORATION

                              ___________________

                                PROXY STATEMENT

                                       OF

                              DR. STEPHEN BURAKOFF
                            DR. ALEXANDER J. DENNER
                               MR. CARL C. ICAHN
                              DR. RICHARD MULLIGAN
                                 DR. ERIC ENDE
                        HIGH RIVER LIMITED  PARTNERSHIP
                             HOPPER INVESTMENTS LLC
                                 BARBERRY CORP.
                               ICAHN PARTNERS LP
                         ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                       ICAHN PARTNERS MASTER FUND III LP
                          ICAHN ENTERPRISES G.P. INC.
                        ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                               ICAHN OFFSHORE LP
                                 BECKTON CORP.
                              ___________________

To Our Fellow Genzyme Shareholders:

     This  Proxy  Statement  and  the  accompanying  GOLD  proxy  card are being
furnished  to  shareholders ("Shareholders") of Genzyme Corporation, 500 Kendall
Street,  Cambridge,  Massachusetts 02142 ("Genzyme," "Corporation" or "Company")
in  connection  with  the  solicitation  of  proxies  by  Carl  C. Icahn and the
Participants  (as  hereinafter  defined),  to be used at the 2010 Annual Meeting
(the  "Annual Meeting") of Shareholders of Genzyme which is scheduled to be held
at  the  American  Academy  of  Arts and Sciences, 136 Irving Street, Cambridge,
Massachusetts,  on June 16, 2010, at 9 a.m. local time, and at any adjournments,
postponements  or continuations thereof. This Proxy Statement and the GOLD proxy
card  are  first  being  furnished  to  Shareholders  on  or  about  [  ].

     At  the Annual Meeting, the Participants will seek to elect to the Board of
Directors  ("Board")  of  Genzyme  the  following  persons (each a "Nominee" and
collectively,  the  "Nominees"):

                              DR. STEPHEN BURAKOFF
                            DR. ALEXANDER J. DENNER
                               MR. CARL C. ICAHN
                              DR. RICHARD MULLIGAN

     The Icahn Parties (as hereinafter defined) believe that Genzyme's inability
to  fully manufacture and supply certain of its products leads to the conclusion
that the manufacturing system at Genzyme is "broken." This conclusion is further
evidenced  by  Genzyme's  subsequent  announcement  of  the  Food  and  Drug
Administration's  enforcement  action. As Board members, the Nominees will work,
subject  to  their fiduciary duties, to understand and then help Genzyme correct
what  they  believe  is  "broken."

     The  Icahn  Parties  believe  that Nominees knowledge of science, medicine,
finance  and  business  will  significantly  improve  the  science  and business
expertise  of  the Board of Directors of Genzyme. The Icahn Parties also believe
that  each  Nominee  is  a  strong shareholder-oriented individual who will help
represent  the  best  interests  of  Genzyme's  shareholders.

     Each  of  our Nominees has consented to being named in this Proxy Statement
and,  if  elected,  to  serve  as  a  director.

     Under  the  proxy rules we may only solicit proxies for our Nominees, which
would result in limiting the ability of Shareholders that would like to vote for
our  Nominees  to  fully  exercise  their voting rights to vote for up to a full
complement of ten directors. Alternatively, we may solicit proxies in support of
our  Nominees  and  also  seek authority to vote for all of the Genzyme nominees
other  than  those  Genzyme nominees we specify. This would enable a Shareholder
who  desires to vote for up to a full complement of ten director nominees to use
the GOLD proxy card to vote for our Nominees as well as the Genzyme nominees for
whom  we are seeking authority to vote other than those nominees as to which the
Shareholder specifically withholds our authority to vote for. We have determined
to  nominate  a  slate  of  four  Nominees, Mr. Icahn, Drs. Burakoff, Denner and
Mulligan and are seeking authority to vote for up to all of the Genzyme nominees
other  than  [ ]. As a result, should a Shareholder so authorize us, on the GOLD
proxy  card,  we  would  cast  votes for our four Nominees and up to six Genzyme
nominees.  None  of the Genzyme nominees for whom we seek authority to vote have
agreed  to  serve with any of our Nominees, if elected. Additionally, if Genzyme
does  not  nominate  the  respective  individuals for which we seek authority to
vote,  our  GOLD  proxy card will not allow such Shareholder to utilize the GOLD
proxy  card  to  vote  for  such  individual.

     THE  PARTICIPANTS  URGE  YOU  TO  VOTE  THE GOLD PROXY CARD FOR DR. STEPHEN
BURAKOFF, DR. ALEXANDER J. DENNER, MR. CARL C. ICAHN AND DR. RICHARD MULLIGAN AS
DIRECTORS.

     The Nominees and each of the other Participants have no interest in Genzyme
other  than through the beneficial ownership (if any) of shares of Common Stock,
par  value  $.01  per share, of Genzyme (the "Common Stock") or other securities
(if  any)  of Genzyme, except as disclosed herein, including the Annexes hereto,
and  in  the case of Dr. Ende pursuant to his Consulting Agreement, as described
herein,  and in the case of Drs. Burakoff and Mulligan, pursuant to an agreement
in  which  certain  affiliates  of Carl C. Icahn have agreed to pay each of Drs.
Burakoff  and  Mulligan  $25,000  and  to indemnify each Nominee (other than Mr.
Icahn) with respect to certain costs incurred by each such Nominee in connection
with the proxy contest relating to the Annual Meeting (the "Nominee Agreement").

     DR.  STEPHEN  BURAKOFF,  DR. ALEXANDER J. DENNER, MR. CARL C. ICAHN AND DR.
RICHARD  MULLIGAN  ARE  COMMITTED  TO  ACTING  IN  THE  BEST  INTEREST  OF  ALL
SHAREHOLDERS  OF GENZYME. THE PARTICIPANTS URGE YOU TO VOTE YOUR GOLD PROXY CARD
FOR  DR.  STEPHEN  BURAKOFF,  DR. ALEXANDER J. DENNER, MR. CARL C. ICAHN AND DR.
RICHARD  MULLIGAN.




                                   IMPORTANT

     According  to Genzyme's Proxy Statement, the Bylaws and applicable law, the
election  of  the  Nominees  requires the affirmative vote of a plurality of the
votes  cast  by  the  holders  of Genzyme's Common Stock at a meeting at which a
quorum  is  present in person or represented by proxy. As a result, your vote is
extremely  important.  We  urge you to mark, sign, date, and return the enclosed
GOLD  proxy  card  to  vote  FOR  the  election  of  each  Nominee.

     WE  URGE YOU NOT TO SIGN ANY PROXY CARD SENT TO YOU BY GENZYME. IF YOU HAVE
ALREADY  DONE  SO,  YOU  MAY  REVOKE YOUR PROXY BY DELIVERING A LATER-DATED GOLD
PROXY  CARD  IN  THE  ENCLOSED  POSTAGE-PREPAID  ENVELOPE,  EXECUTING A VOTE VIA
INTERNET OR TELEPHONE, OR BY VOTING IN PERSON AT THE ANNUAL MEETING. SEE "VOTING
PROCEDURES"  AND  "PROXY  PROCEDURES"  BELOW.

     If  you attend the Annual Meeting and you beneficially own shares of Common
Stock  but  are not the record owner, your mere attendance at the Annual Meeting
WILL  NOT  be  sufficient  to  cancel your prior given proxy card. You must have
written  authority  from  the record owner to vote the shares of Common Stock in
its  name  at  the meeting. Contact D.F. King & Co., Inc. at the number shown in
this  Proxy  Statement  for  assistance  or  if  you  have  any  questions.

     If  you  have  any  questions  or  require any assistance in executing your
proxy,  please  call:

                             D.F. KING & CO., INC.
                  SHAREHOLDERS CALL TOLL-FREE: (800) 347-4750
                 BANKS AND BROKERS CALL COLLECT: (212) 269-5550

    THE PROXY STATEMENT, AS WELL AS OTHER PROXY MATERIALS DISTRIBUTED BY THE
  PARTICIPANTS, ARE AVAILABLE FREE OF CHARGE ONLINE AT WWW.DFKING.COM/GENZYME.

     Only  holders  of  record  of  Genzyme's  Common  Stock  as of the close of
business  on April 9, 2010 (the "Record Date") are entitled to notice of, and to
attend  and to vote at, the Annual Meeting and any adjournments or postponements
thereof.  According  to the definitive proxy statement of Genzyme filed with the
Securities  and  Exchange  Commission  ("Genzyme's  Proxy Statement"), as of the
Record  Date,  there  were  outstanding  266,470,351  shares  of  Common  Stock.
Shareholders  of  record  at  the  close  of business on the Record Date will be
entitled  to  one  vote  at the Annual Meeting for each share of Common Stock of
Genzyme  held  on  the  Record  Date.


     As  of  the Record Date, the Participants and their affiliates beneficially
owned  an  aggregate  of  13,100,000  shares  of  Common  Stock,  representing
approximately  4.92% of the outstanding shares of Common Stock. The Participants
and their affiliates intend to vote such shares of Common Stock FOR the election
of  the  Nominees.

   VOTE FOR THE NOMINEES BY USING THE ENCLOSED GOLD PROXY TO VOTE TODAY - BY
 TELEPHONE, BY INTERNET, OR BY MARKING, SIGNING, DATING AND RETURNING THE GOLD
            PROXY CARD IN THE POSTAGE-PAID ENVELOPE PROVIDED TO YOU.

PARTICIPANTS IN SOLICITATION OF PROXIES

     In addition to the Nominees (who are Dr. Stephen Burakoff, Dr. Alexander J.
Denner,  Mr.  Carl  C.  Icahn and Dr. Richard Mulligan), the participants in the
solicitation  of  proxies  (the  "Participants")  from  Shareholders  of Genzyme
include  the  following:  High  River  Limited  Partnership,  a Delaware limited
partnership ("High River"), Hopper Investments LLC, a Delaware limited liability
company  ("Hopper"),  Barberry Corp., a Delaware corporation ("Barberry"), Icahn
Partners  LP,  a Delaware limited partnership ("Icahn Partners"), Icahn Partners
Master  Fund  LP,  a  Cayman Islands limited partnership ("Icahn Master"), Icahn
Partners  Master Fund II LP, a Cayman Islands limited partnership ("Icahn Master
II"),  Icahn  Partners  Master Fund III LP, a Cayman Islands limited partnership
("Icahn  Master  III"), Beckton Corp., a Delaware corporation ("Beckton"), Icahn
Enterprises  G.P.  Inc.,  a Delaware corporation ("Icahn Enterprises GP"), Icahn
Enterprises  Holdings  L.P.,  a Delaware limited partnership ("Icahn Enterprises
Holdings"),  IPH  GP  LLC,  a  Delaware limited liability company ("IPH"), Icahn
Capital LP, a Delaware limited partnership ("IcahnCapital"), Icahn Onshore LP, a
Delaware  limited  partnership  ("Icahn Onshore"), Icahn Offshore LP, a Delaware
limited  partnership  ("Icahn  Offshore")  and  Dr.  Eric  Ende.


     Icahn  Partners,  Icahn  Master,  Icahn  Master  II  and  Icahn  Master III
(collectively,  the "Funds") and High River (together with the Funds, the "Icahn
Parties"),  are  entities  controlled  by  Mr.  Icahn. Dr. Denner is an employee
and/or  officer  and/or director of the Icahn Parties and various other entities
controlled  by  Mr.  Icahn,  and who will participate in soliciting proxies from
Genzyme  Shareholders.  Dr.  Denner  does  not  own beneficially any interest in
securities  of  Genzyme. Dr. Denner will not receive any special compensation in
connection  with  this  solicitation. In connection with their employment by Mr.
Icahn  and  his  affiliated  companies, Dr. Denner, among other employees, has a
participatory  interest  in the profits and fees derived by Mr. Icahn and/or his
affiliated  entities  in  the  Funds.  Because  only  a  portion  of such profit
interests  are  distributed and because of Dr. Denner's other investments in the
Funds,  Dr.  Denner  also  has  capital accounts in the Funds. Generally, in the
aggregate,  Dr.  Denner's  profit  interests  and  capital accounts in the Funds
entitle  him  to less than 2% of the profits generated by the Funds. Dr. Ende is
an  independent  consultant  retained  by  Icahn  Capital to solicit proxies and
provide consulting services relating to this solicitation and general consulting
services  relating  to other investments by the Icahn Parties. Dr. Ende does not
own  beneficially  any  interest  in  securities of Genzyme. Assuming the Annual
Meeting  of  Genzyme  is  held  in  June  and  further  assuming  the contest is
successful  the  agreement  referred to herein may provide for payments of up to
approximately  $200,000.00. The business address of Dr. Ende is 102 via Palacio,
Palm  Beach  Gardens,  Florida  33418.

     In  consideration  of providing certain investment advisory, administrative
and  back  office  services  to the Funds, Icahn Onshore, the general partner of
Icahn  Partners  and  Icahn Offshore, the general partner of Icahn Master, Icahn
Master  II  and  Icahn  Master  III,  (together,  the  "General  Partners"), are
allocated  from  the  Funds  on  an  annual  basis  (i) special profits interest
allocations  ranging  from  1.5%  to  2.5%  of the balance in each of the Funds'
capital  accounts  attributable to fee-paying investors but such allocations are
made  only  to the extent that there is sufficient profits to cover such amounts
and  (ii)  incentive  allocations,  subject  to  a "Highwater Mark" (whereby the
General Partners do not earn incentive allocations during a particular year even
though the fund had a positive return in such year until losses in prior periods
are  recovered),  ranging  from  15%  to  25%  of  the  net profits generated by
fee-paying  investors  of  the  Funds.  Therefore,  the  amounts received by the
General  Partners will be affected by the combination of fee-paying assets under
management  and  the investment performance of the Funds (including any increase
or decrease in the value of shares of the Corporation). The General Partners are
owned  by  Icahn Capital, which is a subsidiary of Icahn Enterprises L.P., a New
York  Stock  Exchange  listed  master limited partnership ("Icahn Enterprises").
Carl  C. Icahn is the indirect owner of the general partner of Icahn Enterprises
and  the  indirect  holder of approximately 92.34% of the outstanding depositary
units  representing  limited  partnership  interests  in  Icahn  Enterprises.

     Annex  A  attached  hereto  sets  forth,  as  to the Nominees and the other
Participants, all transactions in securities of Genzyme effected during the past
two  years  and  their  beneficial  ownership  of  securities  of  Genzyme.

     With  respect  to  each Participant (including the Nominees), except as set
forth  herein  or in any of the Annexes attached hereto, (i) such Participant is
not,  nor  was  within  the  past  year, a party to any contract, arrangement or
understanding  with  any  person  with  respect  to  any  securities of Genzyme,
including, but not limited to, joint ventures, loan or option arrangements, puts
or calls, guarantees against loss or guarantees of profit, division of losses or
profits,  or  the  giving  or  withholding  of  proxies;  and  (ii) neither such
Participant  nor  any  of  such Participant's associates have any arrangement or
understanding  with  any  person  with  respect  to (A) any future employment by
Genzyme or its affiliates or (B) any future transactions to which Genzyme or any
of  its  affiliates  will  or  may  be  a  party.


PROPOSAL  1  --  ELECTION  OF  DIRECTORS

     Given that the Icahn Parties believe that the Company has not yet been able
to  cure,  among other things, its severe manufacturing and supply problems, the
Icahn Parties believe that a change in Board composition at Genzyme is necessary
to  bring  new  ideas and ways of looking at problems to the existing Board. The
Nominees  are  committed  to  the best interests of all Genzyme Shareholders and
intend  to  work  to  correct  the problems associated with manufacturing and to
improving shareholder value. The Nominees are unable to fully formulate specific
plans  with  respect  to  the  Company  as  they  are  not  privy  to non-public
information  regarding  Genzyme's  manufacturing  problems.  The  Icahn  Parties
believe  that  the  Nominees,  based  upon  their  vast experiences as disclosed
herein,  can  help  to effect positive change at the Company by working with the
other  Board  members  and management in correcting these problems and improving
shareholder  value.

     Article  I,  Section 5, of Genzyme's Amended and Restated Bylaws, effective
May 24, 2007, provide that Shareholder nominations of directors may be made by "
any  shareholder  entitled  to vote for the election of directors at the meeting
who  complies with the notice procedures set forth in this section." On February
19,  2009  the  Icahn  Parties, record holders of Common Stock, delivered timely
notice  in  accordance  with  the  foregoing,  notifying  Genzyme that the Icahn
Parties  intend  to  nominate and will seek to elect at the Annual Meeting - Dr.
Stephen  Burakoff,  Dr.  Alexander  J. Denner, Mr. Carl C. Icahn and Dr. Richard
Mulligan  as  members  of  the  board  of directors of Genzyme. Each Nominee, if
elected,  would  serve  a  one-year  term  and hold office until the 2011 annual
meeting  of  Shareholders  and  until  a  successor  has  been  duly elected and
qualified.  Background information about each of the Nominees is set forth below
and  the  Annexes  attached  hereto.

     According  to  Genzyme's  Proxy  Statement, the Board of Genzyme intends to
nominate  ten  candidates  for election as directors at the Annual Meeting. This
Proxy  Statement  is  soliciting  proxies  to  elect  Dr.  Stephen Burakoff, Dr.
Alexander  J.  Denner, Mr. Carl C. Icahn and Dr. Richard Mulligan, and to enable
Shareholders  to vote for the Genzyme nominees other than [ ]. Therefore, should
a  Shareholder  so authorize us, we will cast votes for our four Nominees and up
to  six  Genzyme  nominees.  None  of  such  Genzyme  nominees  for whom we seek
authority  to  vote  have  agreed to serve with any of our Nominees, if elected.

     If  elected,  the Nominees will be a minority of the directors and will not
alone  be  able to adopt resolutions. However, the Nominees expect to be able to
actively  engage other Board members in full discussion of the issues facing the
Company and resolve them together. By utilizing their respective experiences and
working  constructively with Board members, the Nominees believe they can effect
positive  change  at  the  Company.

     Mr.  Icahn  has  an  interest  in  the  election of directors at the Annual
Meeting  indirectly  through  the beneficial ownership of securities, as further
described  in  Annex  A.  Dr.  Stephen Burakoff, Dr. Alexander J. Denner and Dr.
Richard  Mulligan  are  each  party to a Nominee Agreement, substantially in the
form attached hereto as Annex B, pursuant to which the Icahn Parties have agreed
to  pay  certain  fees  to  each  such  Nominee  (other  than Dr. Denner) and to
indemnify  each such Nominee with respect to certain costs incurred by each such
Nominee  in  connection  with  the proxy contest relating to the Annual Meeting.
Except  as  disclosed  in  this  Proxy Statement, including the Annexes attached
hereto  and  as  provided  in  the Nominee Agreement (which, among other things,
provides  for  a  payment  to  Dr.  Stephen Burakoff and Dr. Richard Mulligan of
$25,000),  none  of  the  Nominees will receive any compensation from any of the
Participants  or  any  of  their  affiliates  in  connection  with  this  proxy
solicitation.  Dr. Stephen Burakoff and Dr. Richard Mulligan have an interest in
the  election  of  directors  at  the  Annual  Meeting  pursuant  to the Nominee
Agreement. Dr. Denner has an interest in the election of directors at the Annual
Meeting  indirectly  through  his  capital accounts and other investments in the
Funds.

     The  Nominees  would  not be barred from being considered independent under
the  independence  requirements  of  The  NASDAQ  Stock  Market,  Inc.  and  the
independence  standards applicable to Genzyme under paragraph (a)(1) of Item 407
of  Regulation  S-K  under  the  Securities  Exchange  Act  of 1934, as amended.


DR. STEPHEN BURAKOFF, age 67

     Dr.  Steven  Burakoff's  principal  occupation  is  serving as Professor of
Medicine,  Hematology and Medical Oncology at the Mount Sinai School of Medicine
and  director  of  the Tisch Cancer Institute at the Mount Sinai Medical Center,
since  2007. Prior to his appointment at Mount Sinai, Dr. Burakoff was the Laura
and  Isaac  Perlmutter  Professor,  New  York  University  School  of  Medicine;
Director, New York University Cancer Institute; and Director, Skirball Institute
of  Biomolecular  Medicine, New York University School of Medicine, from 2000 to
2007.  Previously,  Dr.  Burakoff  was  Chair  of  Pediatric  Oncology  at  the
Dana-Farber  Cancer  Institute; the Margaret M. Dyson Professor of Pediatrics at
the  Harvard  Medical  School, and also received an Honorary Master's of Science
Degree  from  Harvard  University.  He  was  the  recipient of the first Harvard
Medical  School  Excellence  in  Mentoring  Award.  He was also the Ted Williams
Senior Investigator at the Dana-Farber Cancer Institute, and he also served as a
member  of  the  Board  of  Trustees  of  the  Dana-Farber Cancer Institute. Dr.
Burakoff  serves  as  a  member  of the External Advisory Committee at: the Cold
Spring Harbor Laboratory Cancer Center, the Baylor Medical School Cancer Center,
and  the  Cancer  Center  of the University of Massachusetts Medical School, the
Albert  Einstein  College  of  Medicine  Cancer Center and the St. Jude's Cancer
Center.  Dr.  Burakoff  holds  memberships  in  many  professional societies and
organizations,  including:  Alpha  Omega Alpha, the American Society of Clinical
Investigation,  and  the  Association  of  American Physicians, and the American
Association  of Immunologist where he serves as Secretary-Treasurer. He has been
an Editor and Associate Editor for numerous journals and author of more than 300
publications  in  peer-reviewed journals. On May 11, 2009, Dr. Burakoff received
the  American  Association  of  Immunologists  Lifetime  Achievement  Award.  On
September  22,  2009,  Dr.  Burakoff  received the Lillian and Henry M. Stratton
Professor  of  Cancer Medicine endowed professorship from the Mount Sinai School
of  Medicine.  Since  2009,  Dr.  Burakoff  has  served  as a director of Ligand
Pharmaceuticals  Incorporated,  a  publicly  traded royalty-driven biotechnology
company  and  from  2005  through  2008  served as a director of Pharmacopeia, a
publicly  traded  biopharmaceutical  company  which was then acquired by Ligand.

     Dr.  Burakoff  graduated  from Lehigh University with a Bachelor of Science
degree,  received  his  Master's  degree  from Queens College, and his M.D. from
Albany  Medical  College.  Dr.  Burakoff's  business  address  is  Tisch  Cancer
Institute,  Mount Sinai School of Medicine, One Gustave L. Levy Place, New York,
New  York  10029.

     Dr.  Burakoff  is a highly accomplished research oncologist. Based upon Dr.
Burakoff's  medical background and education, the Icahn Parties believe that Dr.
Burakoff  has the requisite set of skills to serve as a Board member of Genzyme.


DR. ALEXANDER J. DENNER, age 40

     Dr.  Denner's  principal  occupation  is  serving  as  Managing Director of
entities  affiliated with Carl C. Icahn, including Icahn Partners, Icahn Master,
Icahn Master II and Icahn Master III. Icahn Partners, Icahn Master, Icahn Master
II  and  Icahn Master III are private investment funds. Dr. Denner has served in
this position since August 2006. Dr. Denner's previous employment was serving as
a  portfolio  manager  specializing  in healthcare investments for Viking Global
Investors  from  April  2005  to May 2006. Previously, he served in a variety of
roles  at  Morgan  Stanley, beginning in 1996, including as portfolio manager of
healthcare  and  biotechnology  mutual funds. Dr. Denner was the chairman of the
Executive Committee of the Board of Directors of ImClone Systems Incorporated, a
publicly  traded  biopharmaceutical  company,  and a director of ImClone Systems
Incorporated  from  April 2006 until the company was purchased in December 2008.
He  served  on  the  Board  of  Adventrx Pharmaceuticals Inc., a publicly traded
biopharmaceutical  company  from  October 2006 to October 2009. In addition, Dr.
Denner  has  served  as  a  director  of Biogen Idec Pharmaceuticals, a publicly
traded  biopharmaceutical  company  from  June,  2009  until  the  present, as a
director  of  Amylin  Pharmaceuticals, Inc., a publicly traded biopharmaceutical
company  since  June  2009,  as  a director of Enzon Pharmaceuticals, a publicly
traded  biopharmaceutical  company  from  May  2009  until  the  present, and as
Chairman  of  the  Board  of  Directors of Enzon Pharmaceuticals from July, 2009
until  the  present.  Dr. Denner received his S.B. degree from the Massachusetts
Institute  of  Technology  and  his  M.S.,  M.Phil., and Ph.D. degrees from Yale
University. The business address of Dr. Denner is c/o Icahn Associates Corp, 767
Fifth  Avenue,  Suite  4700,  New  York,  NY  10153.

     Based  upon  Dr. Denner's experience of overseeing the operations, research
and  development  of  biopharmaceutical  companies;  service  on  boards  of
biopharmaceutical  companies;  financial  background,  including with respect to
biotechnology  companies;  and  education,  the  Icahn  Parties believe that Dr.
Denner  has  the  requisite set of skills to serve as a Board member of Genzyme.

MR. CARL C. ICAHN, age 74

     Carl  C.  Icahn  has  served  as  chairman  of  the board and a director of
Starfire Holding Corporation ("Starfire"), a privately-held holding company, and
chairman  of the board and a director of various subsidiaries of Starfire, since
1984.  Since  August  2007,  through  his position as Chief Executive Officer of
Icahn  Capital  LP,  a wholly-owned subsidiary of Icahn Enterprises L.P. ("Icahn
Enterprises"), and certain related entities, Mr. Icahn's principal occupation is
managing  private  investment funds, including Icahn Partners LP, Icahn Partners
Master Fund LP, Icahn Partners Master Fund II LP, and Icahn Partners Master Fund
III  LP.  From November 2004 to August 2007, Mr. Icahn conducted this occupation
through  his  entities  CCI  Onshore Corp. and CCI Offshore Corp. Since November
1990,  Mr.  Icahn has been chairman of the board of Icahn Enterprises G.P. Inc.,
the  general  partner  of  Icahn Enterprises. Icahn Enterprises is a diversified
holding  company  engaged  in  a  variety  of  businesses,  including investment
management,  metals,  automotive,  real  estate, railcar, food/packaging, casino
gaming  and home fashion. In March 2010, Mr. Icahn was appointed Chairman of the
Board  of  Tropicana  Entertainment Inc., which owns and operates a diversified,
multi-jurisdictional  collection  of  casino  gaming  properties.  Mr. Icahn was
chairman  of  the  board  and  president  of  Icahn  &  Co.,  Inc., a registered
broker-dealer  and  a  member of the National Association of Securities Dealers,
from  1968  to  2005.  Mr.  Icahn  has  served as chairman of the board and as a
director  of  American  Railcar  Industries,  Inc.,  a company that is primarily
engaged in the business of manufacturing covered hopper and tank railcars, since
1994.  From  October  1998  through  May 2004, Mr. Icahn was the president and a
director of Stratosphere Corporation, the owner and operator of the Stratosphere
Hotel  and  Casino in Las Vegas, which, until February 2008, was a subsidiary of
Icahn Enterprises. From September 2000 to February 2007, Mr. Icahn served as the
chairman  of the board of GB Holdings, Inc., which owned an interest in Atlantic
Coast  Holdings,  Inc.,  the  owner and operator of The Sands casino in Atlantic
City  until November 2006. From September 2006 to November 2008, Mr. Icahn was a
director  of  ImClone  Systems  Incorporated  ("ImClone"),  a  biopharmaceutical
company,  and  from  October  2006  to November 2008, he was the chairman of the
board  of ImClone. Mr. Icahn has been chairman of the board and a director of XO
Holdings, Inc., a telecommunications services provider, since February 2006, and
of its predecessor from January 2003 to February 2006. Mr. Icahn has served as a
director  of Cadus Corporation, a company engaged in the ownership and licensing
of  yeast-based  drug  discovery  technologies since July 1993. From May 2005 to
January  2010, Mr. Icahn served as a director of Blockbuster Inc., a provider of
in-home movie rental and game entertainment. In October 2005, Mr. Icahn became a
director  of  WestPoint International, Inc., a manufacturer of bed and bath home
fashion  products.  From August 2007 to September 2009, Mr. Icahn was a director
of  WCI  Communities,  Inc., a homebuilding company. In December 2007, Mr. Icahn
became  a director of Federal-Mogul Corporation ("Federal-Mogul"), a supplier of
automotive  products, and since January 2008, has been the chairman of the board
of  Federal-Mogul. From August 2008 to October 2009, Mr. Icahn was a director of
Yahoo!  Inc.,  a  company that provides Internet services to users, advertisers,
publishers  and developers worldwide. Mr. Icahn received his B.A. from Princeton
University. The business address of Mr. Icahn is c/o Icahn Capital LP, 767 Fifth
Avenue,  Suite  4700,  New  York,  NY  10153.

     Mr.  Icahn  is  internationally  recognized  as  a leading financier and is
generally  known  for  his  financial acumen. Mr. Icahn has had a long career of
serving  on boards of many companies and his focus on various means of enhancing
shareholder  value  for  those  companies.  Based  upon  Mr.  Icahn's  financial
experience  and  expertise,  the  Icahn  Parties  believe that Mr. Icahn has the
requisite  set  of  skills  to  serve  as  a  Board  member  of  Genzyme.

DR. RICHARD MULLIGAN, age 55

     Dr.  Mulligan's  principal  occupation  is  serving  as  the  Mallinckrodt
Professor  of  Genetics  at  Harvard Medical School, and Director of the Harvard
Gene  Therapy  Initiative.  Professor Mulligan received his B.S. degree from the
Massachusetts  Institute  of  Technology,  and  his Ph.D. from the Department of
Biochemistry  at  Stanford  University  School  of  Medicine.  After  receiving
postdoctoral  training  at  the  Center  for  Cancer  Research at MIT, Professor
Mulligan  joined  the  MIT  faculty  and subsequently was appointed Professor of
Molecular  Biology and Member of the Whitehead Institute for Biomedical Research
before moving to Children's Hospital and Harvard in 1996. His honors include the
MacArthur  Foundation  Prize,  the  Rhodes  Memorial  Award  of  the  American
Association  for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation
International  Prize.

     Dr.  Mulligan  served  as  a  director  of  ImClone  System Incorporated, a
publicly  traded  biopharmaceutical  company, from September 2006 until November
2008,  and  as a member of Scientific Advisory Board and Executive Committee. In
addition,  Dr. Mulligan has served as a director of Biogen Idec Pharmaceuticals,
a publicly traded biopharmaceutical company from June 2009 until the present, as
a director of Enzon Pharmaceuticals, a publicly traded biopharmaceutical company
from  May  2009  until  the  present,  and  as  a  director  of  Cellectis SA, a
biotechnology  company  which  specializes in genome engineering, since 2007. He
has  also served on the National Institutes of Health's Recombinant DNA Advisory
Committee  and  on  the  U.S.  Food  and Drug Administration Biological Response
Modifiers  Advisory  Committee.  Dr.  Mulligan's  business  address  is  Harvard
Institutes  of  Medicine Rm 407, 4 Blackfan Circle, Boston, Massachusetts 02115.

     Based  upon  Dr.  Mulligan's  expertise  in  genetics  and  gene  therapy;
experience  in  overseeing  the  operations,  research  and  development  of
biopharmaceutical  companies;  service  on  boards  of  biotechnology  and/or
biopharmaceutical  companies;  and his education, the Icahn Parties believe that
Dr.  Mulligan  has  the  requisite  set  of skills to serve as a Board member of
Genzyme.

     Dr. Denner and Mr. Icahn have no prior relationships with Dr. Burakoff. Dr.
Burakoff  was a professor at Harvard Medical School during Dr. Mulligan's tenure
at  Harvard  Medical  School.

     Drs.  Denner  and  Mulligan  currently  serve  on the Board of Directors of
Biogen  Idec  Inc.  ("Biogen")  and  Enzon Pharmaceuticals, Inc. ("Enzon"). Drs.
Denner  and  Mulligan were elected to the Board of Directors of Biogen Idec Inc.
at  the  2009  Annual  Meeting  of  Stockholders  following  their nomination by
entities  affiliated  with  Mr.  Icahn.  In January 2009, representatives of Mr.
Icahn  and  his  affiliated  entities,  suggested  Drs.  Denner  and Mulligan as
potential directors to the Board of Directors of Enzon. Drs. Denner and Mulligan
were  subsequently  nominated on Enzon's board slate of directors and elected at
the  2009  Annual  Meeting  of  Stockholders.

     Drs.  Denner,  Mulligan  and  Mr.  Icahn  served  together  on the Board of
Directors  of ImClone Systems Incorporated ("ImClone"). Following discussions in
April  2006  between  ImClone  and Mr. Icahn, a then stockholder of ImClone, Dr.
Denner,  who  was  not  then  employed  by affiliated entities of Mr. Icahn, was
appointed  to  the  Board of ImClone. In August 2006, representatives of ImClone
offered  to  nominate on management's slate of directors, Mr. Icahn, Dr. Denner,
then  an  employee  of  entities  affiliated  with  Mr.  Icahn,  and two persons
recommended  to ImClone by Mr. Icahn, including Dr. Richard Mulligan, and all of
such  nominees  were  subsequently  elected  at  the  2006  Annual  Meeting  of
Stockholders.

     As  disclosed  in  this Proxy Statement, Drs. Denner and Mulligan currently
serve on the Board of Directors of Biogen. The Icahn Parties have considered the
applicability  of  Section  8  of  the  Clayton  Act, which includes a statutory
prohibition  on  interlocking  directorates  between competing corporations, and
although  there  can  be  no  assurances,  the  Icahn  Parties  believe that the
prohibitions  thereunder are not applicable because Biogen and the Company would
not now be deemed competitors within the meaning of Section 8 of the Clayton Act
based  upon  the  assumption made by the Icahn Parties, which they believe to be
reasonable,  that sales of drugs by Genzyme and Biogen which might be considered
as  competing  were de minimus, as defined with respect Section 8 of the Clayton
Act,  during  2009.


     The  Icahn Parties do not believe a conflict of interest arises from having
membership  on  the  Board  of Directors of Biogen and Genzyme. The Nominees are
aware that if elected they will have fiduciary obligations to Genzyme regardless
of  any  other  affiliations.  The  Nominees  intend  to  fulfill their distinct
fiduciary obligations to each entity on whose board they serve. Additionally, to
the  extent  there  are  conflicts,  the  Nominees  intend  to  take measures to
otherwise  alleviate  the conflict including, if necessary, recusal with respect
to  the  specific  conflict.

     WE  STRONGLY URGE YOU TO VOTE FOR THE ELECTION OF DR. STEPHEN BURAKOFF, DR.
ALEXANDER  J.  DENNER,  MR.  CARL  C. ICAHN AND DR. RICHARD MULLIGAN BY MARKING,
SIGNING,  DATING  AND RETURNING THE ENCLOSED GOLD PROXY CARD IN THE POSTAGE PAID
ENVELOPE  PROVIDED  TO  YOU WITH THIS PROXY STATEMENT OR BY USING THE GOLD PROXY
CARD  TO  VOTE  BY TELEPHONE OR INTERNET. IF YOU HAVE SIGNED THE GOLD PROXY CARD
AND NO MARKING IS MADE, YOU WILL BE DEEMED TO HAVE GIVEN A DIRECTION TO VOTE ALL
THE  SHARES  OF COMMON STOCK REPRESENTED BY THE GOLD PROXY CARD FOR THE ELECTION
DR. STEPHEN BURAKOFF, DR. ALEXANDER J. DENNER, MR. CARL C. ICAHN AND DR. RICHARD
MULLIGAN  AND  THE  GENZYME  NOMINEES  OTHER  THAN  [  ].


OTHER MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

     According  to Genzyme's Proxy Statement, Genzyme is soliciting proxies with
respect to five other proposals. Please refer to Genzyme's Proxy Statement for a
detailed  discussion of these proposals, including various arguments in favor of
and  against  such  proposals.  These  proposals are outlined below. IF YOU HAVE
SIGNED  THE  GOLD  PROXY CARD AND NO MARKING IS MADE, YOU WILL BE DEEMED TO HAVE
GIVEN  A DIRECTION TO VOTE ALL OF THE SHARES OF COMMON STOCK REPRESENTED BY YOUR
GOLD  PROXY  CARD  [  ]  PROPOSALS  [  ]  LISTED  BELOW.

PROPOSAL 2 -- PROPOSAL TO AMEND 2004 EQUITY INCENTIVE PLAN

     According  to  the  Company's  2010 Definitive Proxy Statement, the Company
will also solicit proxies with respect to a proposal for Shareholders to approve
an  increase  of  2,750,000  shares available for issuance under the 2004 Equity
Incentive  Plan.  Please  refer to the Company's 2010 Definitive Proxy Statement
for  a  discussion  of  such  proposal.  The  Participants  intend  to vote, and
recommend  that  you  vote,  [  ]  this  proposal.

PROPOSAL 3 -- PROPOSAL TO AMEND 2009 EMPLOYEE STOCK PURCHASE PLAN

     According  to  the  Company's 2010 Definitive Proxy Statement, the Company
will also solicit proxies with respect to a proposal for Shareholders to approve
an  increase  of  1,500,000  shares under the 2009 Employee Stock Purchase Plan.
Please  refer to the Company's 2010 Definitive Proxy Statement for a discussion
of  such proposal. The Participants intend to vote, and recommend that you vote,
[  ]  this  proposal.

PROPOSAL 4 -- PROPOSAL TO AMEND 2007 DIRECTOR EQUITY PLAN

     According  to  the  Company's  2010 Definitive Proxy Statement, the Company
will also solicit proxies with respect to a proposal for Shareholders to approve
the  increase  of  250,000 shares available for issuance under the 2007 Director
Equity Plan. Please refer to the Company's 2010 Definitive Proxy Statement for a
discussion of such proposal. The Participants intend to vote, and recommend that
you  vote,  [  ]  this  proposal.

PROPOSAL 5 -- PROPOSAL TO AMEND AND RESTATE OUR CHARTER

     According  to  the  Company's  2010 Definitive Proxy Statement, the Company
will also solicit proxies with respect to a proposal for Shareholders to approve
an amendment to the Company's Restated Articles of Organization to reduce to 40%
the  percentage of shares required for Shareholders to call a special meeting of
Shareholders.  Please refer to the Company's 2010 Definitive Proxy Statement for
a  discussion  of  such proposal. The Participants intend to vote, and recommend
that  you  vote,  [  ]  this  proposal.

PROPOSAL 6 -- PROPOSAL TO RATIFY SELECTION OF AUDITORS

     According  to  the  Company's  2010 Definitive Proxy Statement, the Company
will  also solicit proxies to ratify the selection of PricewaterhouseCoopers LLP
to  serve  as  the auditors for the fiscal year ending December 31, 2010. Please
refer  to the Company's 2010 Definitive Proxy Statement for a discussion of such
proposal. The Participants intend to vote, and recommend that you vote, [ ] this
proposal.

OTHER PROPOSALS

     The  Participants  and  their  affiliates  know  of no other business to be
presented  at  the  Annual  Meeting.  If  any other matters should properly come
before the Annual Meeting, it is intended that the persons named on the enclosed
GOLD  proxy  card  will vote that proxy on such other matters in accordance with
their  judgment.

VOTING PROCEDURES

     According  to  Genzyme's  Proxy  Statement,  the Bylaws and applicable law,
holders  of  shares  of  Genzyme's Common Stock, at the close of business on the
Record  Date are entitled to notice of, and to vote at, the Annual Meeting. Each
share  of Common Stock outstanding on the Record Date is entitled to one vote on
each  matter  presented  at  the  Annual  Meeting.

     According to Genzyme's Proxy Statement, the Bylaws and applicable law, when
the  number  of  nominees  timely  nominated  for  election at an annual meeting
exceeds  the  number  of directors to be elected at the meeting, the election of
directors  at  such  annual  meeting  is  a  contested  election. In a contested
election  directors  are elected by a plurality of the votes cast by the holders
of  Genzyme's  Common Stock at a meeting at which a quorum is present. Plurality
means  that  the  individuals  who  receive the largest number of votes cast are
elected  as directors, up to the maximum number of directors to be chosen at the
meeting.  Consequently,  any  shares  of  Common  Stock  not  voted  (whether by
abstention,  broker  nonvote  or  otherwise)  have  no impact in the election of
directors.  A  quorum is the presence by person or by proxy of a majority of the
shares of Common Stock issued and outstanding and entitled to vote at the Annual
Meeting.  The shares of Common Stock represented by a proxy marked "withhold" or
"abstain"  will  be  considered  present  at  the Annual Meeting for purposes of
determining  a  quorum.

BROKER NON-VOTES

     If  you  hold  your  shares of Common Stock through a bank, broker or other
nominee  and  do  not  provide  voting  instructions to the record holder of the
shares  of  Common  Stock,  your shares of Common Stock will not be voted on any
proposal  on  which your broker or nominee does not have discretionary authority
to  vote.  In  this  case,  a  "broker  non-vote" occurs. Shares of Common Stock
constituting  broker  non-votes  are  not  counted  or  deemed  to be present or
represented  for the purpose of determining whether shareholders have approved a
matter,  but they are counted as present for the purpose of determining a quorum
at  the  Annual  Meeting.

     The  election  of directors at the Annual Meeting is a "non-routine matter"
and  brokers  do  not have discretionary authority to vote your shares of Common
Stock  on  "non-routine  matters." Therefore, unless you provide specific voting
instructions  to  your broker, your broker will not have discretionary authority
to  vote your shares of Common Stock for the election of directors at the Annual
Meeting  and  your  shares of Common Stock will not be voted for the election of
directors.  If  your shares of Common Stock are held in street name, your broker
or  nominee has enclosed a voting instruction card with this Proxy Statement. We
strongly  encourage  you  to  vote  your shares of Common Stock by following the
instructions  provided  on  the  voting  instruction  card.

     According  to Genzyme's Proxy Statement, the Bylaws and applicable law, the
affirmative  vote  of  a majority of shares of Common Stock present in person or
represented  by  proxy  at  the  Annual  Meeting and entitled to vote thereon is
required  to  approve  the  Amendment  to the Restated Articles of Organization.
According  to  Genzyme's  Proxy  Statement,  the  Bylaws and applicable law, the
approval  of  each  of (i) the amendment to the 2004 Equity Incentive Plan; (ii)
the  amendment  to the 2009 Employee Stock Purchase Plan; (iii) the Amendment to
the 2007 Director Equity Plan; and (iv) the ratification of the selection of the
Independent  Registered Accounting Firm require that the number of votes cast in
favor  of  the  proposal  exceed  the number of votes cast against the proposal.

     As  explained  in  the detailed instructions on your GOLD proxy card, there
are  four  ways  you  may  vote.  You  may:

     1.   Sign, date  and  return  the  enclosed  GOLD  proxy  card  in  the
          enclosed postage-paid envelope. We recommend that you vote on the GOLD
          proxy  card  even  if  you  plan  to  attend  the  Annual  Meeting;
     2.   Vote via  the  Internet  by  following  the voting instructions on the
          GOLD  proxy  card  or the voting instructions provided by your broker,
          bank  or  other  holder  of  record.
     3.   Vote by  telephone  by  following  the  voting  instructions  on  the
          GOLD  proxy  card or the instructions provided by your broker, bank or
          other  holder  of  record;  or
     4.   Vote in  person  by  attending  the  Annual  Meeting.  Written ballots
          will  be distributed to Shareholders who wish to vote in person at the
          Annual  Meeting.  If  you  hold  your shares of Common Stock through a
          bank,  broker  or  other custodian, you must obtain a legal proxy from
          such  custodian  in  order  to  vote  in  person  at  the  meeting.

     To  submit  a  proxy  with voting instructions by telephone please call the
telephone  number  listed  on the GOLD proxy card. Proxies may also be submitted
over  the  Internet.  Please  refer  to  the  GOLD  proxy  card  for the website
information.  In  each  case Shareholders will be required to provide the unique
control  number which has been printed on each Shareholder's GOLD proxy card. In
addition  to  the  instructions that appear on the GOLD proxy card, step-by-step
instructions  will  be  provided  by  a  recorded  telephone  message  for those
Shareholders  submitting  proxies by telephone, or at the designated website for
those Shareholders submitting proxies over the Internet. Shareholders submitting
their  proxies  with  voting instructions by telephone or over the Internet will
receive  confirmation  on  the  telephone  that  their  vote  by  telephone  was
successfully  submitted,  and may provide an email address for confirmation that
their  vote  by  Internet  was  successfully  submitted.

     Whether  or not you are able to attend the Annual Meeting, you are urged to
complete  the  enclosed GOLD proxy and return it in the enclosed self-addressed,
prepaid envelope. All valid proxies received prior to the meeting will be voted.
If  you specify a choice with respect to any item by marking the appropriate box
on  the  proxy, the shares of Common Stock will be voted in accordance with that
specification.  IF  NO SPECIFICATION IS MADE, THE SHARES OF COMMON STOCK WILL BE
VOTED  (I)  FOR  DR.  STEPHEN  BURAKOFF  FOR DIRECTOR; (II) FOR DR. ALEXANDER J.
DENNER  FOR  DIRECTOR;  (III)  FOR  MR.  CARL C. ICAHN FOR DIRECTOR (IV) FOR DR.
RICHARD  MULLIGAN  FOR  DIRECTOR  (V) FOR THE PERSONS WHO HAVE BEEN NOMINATED BY
GENZYME  TO  SERVE  AS  DIRECTORS, OTHER THAN [ ]; (VI) [ ] THE AMENDMENT TO THE
2004  EQUITY  INCENTIVE PLAN; (VII) [ ] THE AMENDMENT TO THE 2009 EMPLOYEE STOCK
PURCHASE PLAN; (VIII) [ ] THE AMENDMENT TO THE 2007 DIRECTOR EQUITY PLAN; (IX) [
]THE AMENDMENT TO THE RESTATED ARTICLES OF ORGANIZATION; (X) [ ]THE RATIFICATION
OF  THE SELECTION OF THE INDEPENDENT REGISTERED ACCOUNTING FIRM; AND (XI) IN THE
PROXY  HOLDERS' DISCRETION AS TO OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE
ANNUAL  MEETING.


     If  you  have  any  questions  or  require any assistance in executing your
proxy,  please  call:

                             D.F. KING & CO., INC.
                  SHAREHOLDERS CALL TOLL-FREE: (800) 347-4750
                 BANKS AND BROKERAGE FIRMS CALL: (212) 269-5550

PROXY PROCEDURES

     IN  ORDER  FOR  YOUR  VIEWS TO BE REPRESENTED AT THE ANNUAL MEETING, PLEASE
MARK,  SIGN,  DATE  AND  RETURN  THE  ENCLOSED  GOLD  PROXY CARD IN THE ENCLOSED
POSTAGE-PREPAID  ENVELOPE  OR  USE  THE  GOLD PROXY CARD TO VOTE BY TELEPHONE OR
INTERNET.

     The  accompanying  GOLD  proxy  card will be voted at the Annual Meeting in
accordance  with  your  instructions  on  such  card.

     Only  holders of record as of the close of business on the Record Date will
be entitled to vote. If you were a Shareholder of record on the Record Date, you
will  retain  your  voting  rights  at  the Annual Meeting even if you sell such
shares  of Common Stock after the Record Date. Accordingly, it is important that
you  vote  the shares of Common Stock held by you on the Record Date, or grant a
proxy  to  vote  such shares of Common Stock on the GOLD proxy card, even if you
sell  such  shares  of  Common  Stock  after  the  Record  Date.

     IF  YOUR  SHARES  OF COMMON STOCK ARE HELD IN THE NAME OF A BROKERAGE FIRM,
BANK,  BANK  NOMINEE  OR  OTHER INSTITUTION ON THE RECORD DATE, ONLY IT CAN VOTE
SUCH SHARES OF COMMON STOCK AND ONLY UPON RECEIPT OF YOUR SPECIFIC INSTRUCTIONS.
ACCORDINGLY, PLEASE CONTACT THE PERSON RESPONSIBLE FOR YOUR ACCOUNT AND INSTRUCT
THAT  PERSON  TO EXECUTE ON YOUR BEHALF THE GOLD PROXY CARD AS SOON AS POSSIBLE.

REVOCATION OF PROXIES

     Any  Shareholder  of  record  may  revoke  or  change  his  or  her  proxy
instructions  at  any  time  prior  to  the  vote  at  the  Annual  Meeting  by:

     -    submitting  a  properly  executed,  subsequently  dated  GOLD  proxy
          card that will revoke all prior proxy cards, including any white proxy
          cards  which  you  may  have  submitted  to  Genzyme;

     -    instructing  the  Icahn  Parties  by  telephone or via the Internet as
          to  how you would like your shares of Common Stock voted (instructions
          are  on  your  GOLD  proxy  card);

     -    attending  the  Annual  Meeting  and  withdrawing  his or her proxy by
          voting  in  person (although attendance at the Annual Meeting will not
          in  and  of  itself  constitute  revocation  of  a  proxy);  or

     -    delivering  written  notice  of  revocation  either  to  the  Icahn
          Parties c/o D.F. King & Co., Inc., 48 Wall Street, New York, NY 10005,
          or  the  Corporate  Secretary  of  Genzyme.

     Although  a  revocation  is  effective  if  delivered to Genzyme, the Icahn
Parties  request  that either the original or a copy of any revocation be mailed
to  the  Icahn  Parties  c/o D.F. King & Co., Inc., 48 Wall Street, New York, NY
10005,  so  that  the  Icahn  Parties  will  be  aware  of  all  revocations.

     IF  YOU  PREVIOUSLY  SIGNED  AND RETURNED A WHITE PROXY CARD TO GENZYME, WE
URGE  YOU  TO  REVOKE  IT BY (1) MARKING, SIGNING, DATING AND RETURNING THE GOLD
PROXY  CARD,  (2)  INSTRUCTING US BY TELEPHONE OR VIA THE INTERNET AS TO HOW YOU
WOULD  LIKE  YOUR  SHARES  OF  COMMON STOCK VOTED WITH RESPECT TO THE GOLD PROXY
CARD,  (3) ATTENDING THE ANNUAL MEETING AND VOTING IN PERSON OR (4) DELIVERING A
WRITTEN  NOTICE OF REVOCATION TO THE ICAHN PARTIES OR TO THE CORPORATE SECRETARY
OF  THE  COMPANY.

COST AND METHOD OF SOLICITATION

     Solicitation  of  proxies will be made by Mr. Icahn, Drs. Burakoff, Denner,
Ende  and  Mulligan.


     Pursuant  to  an Agreement dated April 27, 2010, Icahn Capital has retained
D.F.  King & Co., Inc. ("D.F. King") to conduct the solicitation, for which D.F.
King  is  to receive a fee of up to $175,000, plus expenses and a success fee of
up  to $175,000. Icahn Capital has agreed to indemnify D.F. King against certain
liabilities  and  expenses,  including  certain  liabilities  under  the federal
securities  laws.  Insofar  as indemnification for liabilities arising under the
federal  securities laws may be permitted to D.F. King pursuant to the foregoing
provisions,  we  have  been  informed  that in the opinion of the Securities and
Exchange  Commission,  such  indemnification  is  against  public  policy and is
therefore  unenforceable.  Proxies  may  be solicited by mail, courier services,
Internet,  advertising,  telephone or telecopier or in person. It is anticipated
that  D.F.  King  will  employ up to 100 persons to solicit proxies from Genzyme
Shareholders  for  the Annual Meeting. The total expenditures in furtherance of,
or in connection with, the solicitation of proxies is approximately to date, and
is  estimated  to  be  [  ]  in  total.

     The Icahn Parties will pay all costs associated with this solicitation. The
Icahn  Parties  do  not  intend to seek reimbursement for the costs and expenses
associated with the proxy solicitation in the event that any of the Nominees are
elected  to  the  Board  of  Directors  of  Genzyme.


ADDITIONAL INFORMATION

     Certain  information  regarding the securities of Genzyme held by Genzyme's
directors,  management  and  5%  Shareholders  is  contained  in Genzyme's Proxy
Statement.  Information  concerning  the  date  by  which  proposals of security
holders  intended  to be presented at the next annual meeting of Shareholders of
Genzyme  must  be received by Genzyme for inclusion in Genzyme's Proxy Statement
and  form  of  proxy  for  that  meeting  is  also  contained in Genzyme's Proxy
Statement.  This  information  is  expected  to be contained in Genzyme's public
filings.  The  Participants  take  no  responsibility  for  the  accuracy  or
completeness  of  such  information  contained  in  Genzyme's  public  filings.


Date:  [ ]

                                               DR. STEPHEN BURAKOFF
                                               DR. ALEXANDER J. DENNER
                                               MR. CARL C. ICAHN
                                               DR. RICHARD MULLIGAN
                                               DR. ERIC ENDE
                                               HIGH RIVER LIMITED PARTNERSHIP
                                               HOPPER INVESTMENTS LLC
                                               BARBERRY CORP.
                                               ICAHN PARTNERS LP
                                               ICAHN PARTNERS MASTER FUND LP
                                               ICAHN PARTNERS MASTER FUND II LP
                                               ICAHN PARTNERS MASTER FUND III LP
                                               ICAHN ENTERPRISES G.P. INC.
                                               ICAHN ENTERPRISES HOLDINGS L.P.
                                               IPH GP LLC
                                               ICAHN CAPITAL L.P.
                                               ICAHN ONSHORE LP
                                               ICAHN OFFSHORE LP
                                               BECKTON CORP.




                                                                         ANNEX A

                     SECURITY OWNERSHIP OF THE PARTICIPANTS
                     --------------------------------------

(1) TITLE OF      (2) NAME OF             (3) AMOUNT OF         (4) PERCENT OF
    CLASS             BENEFICIAL              BENEFICIAL            CLASS (2)
                      OWNER (1)               OWNERSHIP
    --------          ----------              ----------            ----------
Common Stock, par     High River               2,620,000               0.98%
value $0.01 per
share ("Shares")
Shares                Icahn Partners           3,873,541               1.45%
Shares                Icahn Master             4,359,306               1.64%
Shares                Icahn Master II          1,630,324               0.61%
Shares                Icahn Master III           616,829               0.23%


_________________________
(1)  Please note that each record holder listed in this table is, as of the date
     of  this  filing, the direct beneficial owner of the Shares set forth under
     the  heading  "(3)  Amount  of  Beneficial  Ownership"  and  that  indirect
     beneficial ownership of Shares is described below in the text of this Annex
     A  under  the  heading  "Description  of  Beneficial  Ownership."

(2)  Please  note  that  percentages  of ownership set forth in this column were
     calculated based on the number of Shares stated to be outstanding as of the
     Record  Date  by  the  Corporation  in  the  Corporation's Definitive Proxy
     Statement.




           DESCRIPTION OF BENEFICIAL OWNERSHIP AND BENEFICIAL OWNERS


     Barberry  Corp., a Delaware corporation ("Barberry"), is the sole member of
Hopper  Investments  LLC, a Delaware limited liability company ("Hopper"), which
is  the  general  partner  of  High River. Beckton Corp., a Delaware corporation
("Beckton")  is  the sole stockholder of Icahn Enterprises G.P. Inc., a Delaware
corporation  ("Icahn  Enterprises  GP"),  which  is the general partner of Icahn
Enterprises  Holdings  L.P.,  a Delaware limited partnership ("Icahn Holdings").
Icahn  Holdings  is  the sole member of IPH GP LLC, a Delaware limited liability
company  ("IPH"), which is the general partner of Icahn Capital L.P., a Delaware
limited  partnership  ("Icahn Capital"). Icahn Capital is the general partner of
each  of  Icahn Onshore LP, a Delaware limited partnership ("Icahn Onshore") and
Icahn  Offshore  LP,  a  Delaware  limited partnership ("Icahn Offshore"). Icahn
Onshore  is the general partner of Icahn Partners. Icahn Offshore is the general
partner  of  each of Icahn Master, Icahn Master II and Icahn Master III. Each of
Barberry  and  Beckton  is  100 percent owned by Carl C. Icahn ("Mr. Icahn," and
collectively  with  Barberry,  Hopper,  Beckton,  Icahn  Enterprises  GP,  Icahn
Holdings,  IPH,  Icahn  Capital,  Icahn Onshore, Icahn Offshore, the "Beneficial
Owners"  and  each  of  them  a  "Beneficial  Owner." As such, Mr. Icahn is in a
position  indirectly  to  determine  the investment and voting decisions made by
each  of  the  Icahn  Parties.

     The  principal  business  address  of  each  of  (i)  Icahn Offshore, Icahn
Onshore, Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP and Beckton is
White Plains Plaza, 445 Hamilton Avenue - Suite 1210, White Plains, NY 10601 and
(ii)  Barberry and Hopper is c/o Icahn Capital LP, 767 Fifth Avenue, 47th Floor,
New  York,  NY  10153.  The  address of Icahn Partners is 767 Fifth Avenue, 47th
Floor,  New  York,  NY  10153.  The  address  of Icahn Master is c/o Walkers SPV
Limited,  P.O.  Box  908GT,  87  Mary  Street, George Town, Grand Cayman, Cayman
Islands.  The  address  of  Icahn  Master  II is c/o Walkers SPV Limited, Walker
House,  87  Mary Street, George Town, Grand Cayman KY1-9002, Cayman Islands. The
address  of  Icahn  Master III is c/o Walkers SPV Limited, Walker House, 87 Mary
Street,  George Town, Grand Cayman KY1-9002, Cayman Islands. The address of High
River  is  767  Fifth  Avenue,  47th  Floor,  New  York,  NY  10153.

     Barberry is primarily engaged in the business of serving as the sole member
of  Hopper  and  investing  in  securities.  Hopper  is primarily engaged in the
business  of  serving  as  the  general  partner  of High River and investing in
securities.  Icahn  Offshore  is primarily engaged in the business of serving as
the  general  partner  of each of Icahn Master, Icahn Master II and Icahn Master
III.  Icahn  Onshore  is  primarily  engaged  in  the business of serving as the
general  partner  of  Icahn  Partners. Icahn Capital is primarily engaged in the
business  of  serving as the general partner of each of Icahn Offshore and Icahn
Onshore.  IPH  is  primarily  engaged  in the business of serving as the general
partner of Icahn Capital. Icahn Holdings is primarily engaged in the business of
holding  direct  or  indirect  interests  in various operating businesses. Icahn
Enterprises  GP  is  primarily engaged in the business of serving as the general
partner  of  each  of Icahn Enterprises and Icahn Holdings. Beckton is primarily
engaged  in  the  business of holding the capital stock of Icahn Enterprises GP.
Each  of  High  River,  Icahn  Master,  Icahn Master II, Icahn Master III, Icahn
Partners  and  High  River are primarily engaged in the business of investing in
securities.

     The  Icahn  Parties and Carl C. Icahn may be deemed to beneficially own, in
the  aggregate,  13,100,000  Shares,  representing  approximately  4.92%  of the
Corporation's outstanding Shares (based upon the 266,470,351 Shares stated to be
outstanding  as  of  the  Record  Date  by  the Corporation in the Corporation's
Definitive  Proxy filed with the Securities and Exchange Commission on April 26,
2010).

     High  River has sole voting power and sole dispositive power with regard to
2,620,000 Shares. Each of Hopper, Barberry and Mr. Icahn has shared voting power
and shared dispositive power with regard to such Shares. Icahn Partners has sole
voting power and sole dispositive power with regard to 3,873,541 Shares. Each of
Icahn Onshore, Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP, Beckton
and  Mr.  Icahn has shared voting power and shared dispositive power with regard
to  such  Shares.  Icahn Master has sole voting power and sole dispositive power
with  regard  to  4,359,306  Shares. Each of Icahn Offshore, Icahn Capital, IPH,
Icahn  Holdings,  Icahn  Enterprises GP, Beckton and Mr. Icahn has shared voting
power  and  shared dispositive power with regard to such Shares. Icahn Master II
has  sole  voting  power  and  sole  dispositive  power with regard to 1,630,324
Shares.  Each  of  Icahn  Offshore,  Icahn  Capital,  IPH, Icahn Holdings, Icahn
Enterprises  GP,  Beckton  and  Mr.  Icahn  has  shared  voting power and shared
dispositive  power  with regard to such Shares. Icahn Master III has sole voting
power  and  sole  dispositive power with regard to 616,829 Shares. Each of Icahn
Offshore,  Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP, Beckton and
Mr.  Icahn  has  shared voting power and shared dispositive power with regard to
such  Shares.

     Each of Hopper, Barberry and Mr. Icahn, by virtue of their relationships to
High  River,  may  be deemed to indirectly beneficially own the 2,620,000 Shares
which  High  River  directly  beneficially  owns.  Each  of Icahn Onshore, Icahn
Capital,  IPH,  Icahn  Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn, by
virtue  of  their  relationships  to Icahn Partners, may be deemed to indirectly
beneficially own the 3,873,541 Shares which Icahn Partners directly beneficially
owns.  Each  of  Icahn  Offshore,  Icahn  Capital,  IPH,  Icahn  Holdings, Icahn
Enterprises GP, Beckton and Mr. Icahn, by virtue of their relationships to Icahn
Master,  Icahn  Master  II  and  Icahn  Master  III, may be deemed to indirectly
beneficially  own  the  6,606,459 Shares which Icahn Master, Icahn Master II and
Icahn  Master  III  directly  beneficially  own.

     On January 5, 2001, Reliance Group Holdings, Inc. ("Reliance") commenced an
action in the United States District Court for the Southern District of New York
against  Mr.  Icahn,  Icahn  Associates  Corp. and High River alleging that High
River's  tender offer for Reliance 9% senior notes violated Section 14(e) of the
Exchange  Act. Reliance sought a temporary restraining order and preliminary and
permanent injunctive relief to prevent defendants from purchasing the notes. The
Court  initially  imposed  a  temporary  restraining  order.  Defendants  then
supplemented  the tender offer disclosures. The Court conducted a hearing on the
disclosures  and  other  matters  raised by Reliance. It then denied plaintiff's
motion  for  a  preliminary  injunction and ordered dissolution of its temporary
restraining  order  following  dissemination of the supplement. Reliance took an
immediate  appeal  to  the United States Court of Appeals for the Second Circuit
and  sought  a  stay  to  restrain  defendants  from purchasing notes during the
pendency  of  the  appeal.  On  January  30,  2001,  the Court of Appeals denied
plaintiff's  stay  application.  On  January  30, Reliance also sought a further
temporary  restraining  order  from the District Court. The Court considered the
matter  and  reimposed  its original restraint until noon the next day, at which
time the restraint was dissolved. The appeal was argued on March 9 and denied on
March  22,  2001.


                            TWO YEAR SUMMARY TABLE:

The  following  table indicates the date of each purchase and sale of Shares, as
well as the exercise of any call options, if any, by the Participants and by Mr.
Icahn  and his affiliates within the past two years, and the number of shares in
each  such  purchase  and  sale.

                                                  SHARES PURCHASED/(SOLD)
NAME                          DATE                AND CALL OPTIONS EXERCISED
- ----                          ----                ------------------------------
High River                  8/19/2009                          8,800
High River                  8/25/2009                        157,475
High River                  8/27/2009                         16,000
High River                  8/28/2009                        117,725
High River                  8/31/2009                         12,600
High River                   9/2/2009                          7,400
High River                   9/8/2009                         30,000
High River                  9/10/2009                         10,000
High River                  9/16/2009                          2,700
High River                  10/1/2009                         20,740
High River                 10/27/2009                         66,000
High River                  11/2/2009                         30,000
High River                 12/21/2009                          8,600
High River                 12/22/2009                          5,000
High River                 12/28/2009                      1,048,830 (3)
High River                  1/28/2010                          9,180
High River                   2/5/2010                         65,400
High River                   2/8/2010                          4,774
High River                   2/9/2010                          2,385
High River                  2/10/2010                         23,792
High River                  2/11/2010                         25,940
High River                  2/12/2010                          4,472
High River                  2/16/2010                        116,000
High River                  2/17/2010                        116,120
High River                  2/18/2010                         81,000
High River                  2/19/2010                         40,000
High River                  2/23/2010                             20
High River                  2/25/2010                         12,508
High River                   3/4/2010                          5,060
High River                  3/24/2010                        400,000
High River                  3/25/2010                        171,479
Icahn Partners              8/19/2009                         12,050
Icahn Partners              8/25/2009                        215,637
Icahn Partners              8/27/2009                         21,910
Icahn Partners              8/28/2009                        161,204
Icahn Partners              8/31/2009                         17,254
Icahn Partners               9/2/2009                         11,139
Icahn Partners               9/8/2009                         41,175
Icahn Partners              9/10/2009                         13,725
Icahn Partners              9/16/2009                          3,705
Icahn Partners              10/1/2009                         29,874
Icahn Partners             10/27/2009                         90,853
Icahn Partners              11/2/2009                         74,457
Icahn Partners             12/21/2009                         12,380
Icahn Partners             12/22/2009                          7,198
Icahn Partners             12/28/2009                      1,507,035 (4)
Icahn Partners               2/5/2010                        170,634
Icahn Partners               2/8/2010                          7,059
Icahn Partners               2/9/2010                          3,527
Icahn Partners              2/10/2010                         35,182
Icahn Partners              2/11/2010                         38,358
Icahn Partners              2/12/2010                          6,611
Icahn Partners              2/16/2010                        171,528
Icahn Partners              2/17/2010                        171,707
Icahn Partners              2/18/2010                        118,393
Icahn Partners              2/19/2010                         59,120
Icahn Partners              2/23/2010                             29
Icahn Partners              2/25/2010                         18,487
Icahn Partners               3/4/2010                          8,402
Icahn Partners              3/24/2010                        591,385
Icahn Partners              3/25/2010                        253,523
Icahn Master                8/19/2009                         14,837
Icahn Master                8/25/2009                        265,515
Icahn Master                8/27/2009                         26,977
Icahn Master                8/28/2009                        198,493
Icahn Master                8/31/2009                         21,244
Icahn Master                 9/2/2009                         12,682
Icahn Master                 9/8/2009                         50,601
Icahn Master                9/10/2009                         16,868
Icahn Master                9/16/2009                          4,554
Icahn Master                10/1/2009                         37,434
Icahn Master               10/27/2009                        111,736
Icahn Master                11/2/2009                         45,543
Icahn Master                11/4/2009                         66,921
Icahn Master               11/13/2009                         75,664
Icahn Master               11/16/2009                        206,077
Icahn Master               11/18/2009                         91,658
Icahn Master               12/21/2009                         14,720
Icahn Master               12/22/2009                          8,559
Icahn Master                 1/5/2010                      1,369,237 (5)
Icahn Master                 2/5/2010                         50,688
Icahn Master                 2/8/2010                          7,945
Icahn Master                 2/9/2010                          3,969
Icahn Master                2/10/2010                         39,595
Icahn Master                2/11/2010                         43,168
Icahn Master                2/12/2010                          7,441
Icahn Master                2/16/2010                        193,041
Icahn Master                2/17/2010                        193,240
Icahn Master                2/18/2010                        137,241
Icahn Master                2/19/2010                         66,615
Icahn Master                2/23/2010                             34
Icahn Master                2/25/2010                         20,829
Icahn Master                 3/4/2010                          5,317
Icahn Master                3/24/2010                        665,546
Icahn Master                3/25/2010                        285,317
Icahn Master II             8/19/2009                          6,020
Icahn Master II             8/25/2009                        107,728
Icahn Master II             8/27/2009                         10,945
Icahn Master II             8/28/2009                         80,534
Icahn Master II             8/31/2009                          8,621
Icahn Master II              9/2/2009                          4,099
Icahn Master II              9/8/2009                         20,433
Icahn Master II             9/10/2009                          6,809
Icahn Master II             9/16/2009                          1,839
Icahn Master II             10/1/2009                         11,623
Icahn Master II            10/27/2009                         44,516
Icahn Master II             11/4/2009                         19,324
Icahn Master II            11/13/2009                         27,937
Icahn Master II            11/16/2009                         76,091
Icahn Master II            11/18/2009                         33,843
Icahn Master II            11/24/2009                         44,702
Icahn Master II            11/30/2009                         49,668
Icahn Master II             12/3/2009                         56,250
Icahn Master II             12/4/2009                         27,122
Icahn Master II             12/7/2009                         49,222
Icahn Master II             12/8/2009                         36,918
Icahn Master II             12/9/2009                         37,641
Icahn Master II            12/15/2009                         49,223
Icahn Master II            12/16/2009                        116,909
Icahn Master II            12/17/2009                         12,306
Icahn Master II            12/21/2009                          5,291
Icahn Master II            12/22/2009                          3,076
Icahn Master II             1/28/2010                         27,387
Icahn Master II              2/5/2010                         29,014
Icahn Master II              2/8/2010                          2,969
Icahn Master II              2/9/2010                          1,482
Icahn Master II             2/10/2010                         14,794
Icahn Master II             2/11/2010                         16,129
Icahn Master II             2/12/2010                          2,781
Icahn Master II             2/16/2010                         72,128
Icahn Master II             2/17/2010                         72,202
Icahn Master II             2/18/2010                         49,603
Icahn Master II             2/19/2010                         24,856
Icahn Master II             2/23/2010                             12
Icahn Master II             2/25/2010                          7,773
Icahn Master II              3/4/2010                          4,898
Icahn Master II             3/24/2010                        248,901
Icahn Master II             3/25/2010                        106,705
Icahn Master III            8/19/2009                          2,293
Icahn Master III            8/25/2009                         41,022
Icahn Master III            8/27/2009                          4,168
Icahn Master III            8/28/2009                         30,667
Icahn Master III            8/31/2009                          3,281
Icahn Master III             9/2/2009                          1,680
Icahn Master III             9/8/2009                          7,791
Icahn Master III            9/10/2009                          2,598
Icahn Master III            9/16/2009                            702
Icahn Master III            10/1/2009                          4,029
Icahn Master III           10/27/2009                         16,895
Icahn Master III           12/21/2009                          2,009
Icahn Master III           12/22/2009                          1,167
Icahn Master III           12/28/2009                        241,572 (6)
Icahn Master III            1/28/2010                          9,332
Icahn Master III             2/5/2010                         11,264
Icahn Master III             2/8/2010                          1,124
Icahn Master III             2/9/2010                            563
Icahn Master III            2/10/2010                          5,599
Icahn Master III            2/11/2010                          6,105
Icahn Master III            2/12/2010                          1,053
Icahn Master III            2/16/2010                         27,303
Icahn Master III            2/17/2010                         27,331
Icahn Master III            2/18/2010                         18,763
Icahn Master III            2/19/2010                          9,409
Icahn Master III            2/23/2010                              5
Icahn Master III            2/25/2010                          2,941
Icahn Master III             3/4/2010                          1,623
Icahn Master III            3/24/2010                         94,168
Icahn Master III            3/25/2010                         40,372
_________________________
(3)  High River  acquired  these  Shares  upon  the  exercise of call options as
     described  on  Attachment  I-A  to  this  Annex  A.
(4)  Icahn Partners  acquired  these Shares upon the exercise of call options as
     described  on  Attachment  I-A  to  this  Annex  A.
(5)  Icahn Master  acquired  these  Shares  upon the exercise of call options as
     described  on  Attachment  I-A  to  this  Annex  A.
(6)  Icahn Master III acquired these Shares upon the exercise of call options as
     described  on  Attachment  I-A  to  this  Annex  A.

Shares  of Common Stock purchased by each of the Icahn Parties are maintained in
margin  accounts that include positions in securities in addition to the shares.
As  of  April  26, 2010, the indebtedness of the margin account of each of Icahn
Partners,  Icahn  Master,  Icahn Master II, Icahn Master III and High River were
approximately  $62,996,468,  $83,120,686,  $28,174,139,  $18,180,300,  and
$650,717,210,  respectively.



                                                                         ANNEX A
                                                                  ATTACHMENT 1-A

The  following  are American call options purchased by the Record Holders, which
were  written  by  UBS  AG  with a $33.25 strike price and an expiration date of
November  4, 2011, and which provide for physical settlement.  These are further
described in the chart set forth below.  On December 28, 2009, High River, Icahn
Partners  and  Icahn  Master III and on January 5, 2010, Icahn Master, exercised
all  of  their  respective call options as further described in the chart below.

                                         NUMBER OF SHARES
NAME                    DATE             SUBJECT TO OPTION             PREMIUM
- ----                    ----             -----------------             -------
High River            11/04/2009             40,000.00                715,388.00
High River            11/13/2009             45,000.00                781,006.50
High River            11/16/2009            122,560.00              2,036,689.82
High River            11/18/2009             54,512.00                900,091.24
High River            11/24/2009             72,000.00              1,213,646.40
High River            11/30/2009             80,000.00              1,408,896.00
High River            12/02/2009              4,493.00                 79,692.34
High River            12/03/2009             95,000.00              1,658,500.50
High River            12/04/2009             44,080.00                737,387.87
High River            12/07/2009             80,000.00              1,325,744.00
High River            12/08/2009             60,000.00                966,522.00
High River            12/09/2009             61,177.00                970,212.16
High River            12/15/2009             80,000.00              1,283,200.00
High River            12/16/2009            190,008.00              3,003,038.44
High River            12/17/2009             20,000.00                305,080.00
Icahn Partners        11/04/2009             66,516.00              1,189,618.71
Icahn Partners        11/13/2009             65,797.00              1,141,952.99
Icahn Partners        11/16/2009            179,202.00              2,977,960.92
Icahn Partners        11/18/2009             79,706.00              1,316,089.53
Icahn Partners        11/24/2009            105,273.00              1,774,502.74
Icahn Partners        11/30/2009            116,973.00              2,060,034.90
Icahn Partners        12/03/2009            123,029.00              2,147,827.98
Icahn Partners        12/04/2009             63,456.00              1,061,517.35
Icahn Partners        12/07/2009            115,164.00              1,908,474.78
Icahn Partners        12/08/2009             86,372.00              1,391,340.64
Icahn Partners        12/09/2009             88,067.00              1,396,663.36
Icahn Partners        12/15/2009            115,164.00              1,847,230.56
Icahn Partners        12/16/2009            273,527.00              4,323,039.53
Icahn Partners        12/17/2009             28,789.00                439,147.41
Icahn Master          11/24/2009            121,064.00              2,040,679.00
Icahn Master          11/30/2009            134,514.00              2,368,952.96
Icahn Master          12/02/2009             17,972.00                318,769.36
Icahn Master          12/03/2009            179,438.00              3,132,610.66
Icahn Master          12/04/2009             75,454.00              1,262,224.69
Icahn Master          12/07/2009            136,942.00              2,269,375.44
Icahn Master          12/08/2009            102,706.00              1,654,460.14
Icahn Master          12/09/2009            104,720.00              1,660,764.95
Icahn Master          12/15/2009            136,941.00              2,196,533.64
Icahn Master          12/16/2009            325,249.00              5,140,495.40
Icahn Master          12/17/2009             34,237.00                522,251.20
Icahn Master III      11/04/2009              7,239.00                129,467.34
Icahn Master III      11/13/2009             10,602.00                184,005.13
Icahn Master III      11/16/2009             28,870.00                479,758.77
Icahn Master III      11/18/2009             12,841.00                212,028.02
Icahn Master III      11/24/2009             16,961.00                285,898.01
Icahn Master III      11/30/2009             18,845.00                331,883.06
Icahn Master III      12/03/2009             21,283.00                371,556.49
Icahn Master III      12/04/2009             10,288.00                172,101.78
Icahn Master III      12/07/2009             18,672.00                309,428.65
Icahn Master III      12/08/2009             14,004.00                225,586.23
Icahn Master III      12/09/2009             14,279.00                226,452.09
Icahn Master III      12/15/2009             18,672.00                299,498.88
Icahn Master III      12/16/2009             44,348.00                700,911.27
Icahn Master III      12/17/2009              4,668.00                 71,205.67



                                                                         ANNEX A
                                                                  ATTACHMENT 1-B

The  following are European put options which were written by the Record Holders
to  UBS  AG and have a $33.25 strike price and an expiration date of November 4,
2011,  and  provide  for  cash  settlement only and are further described in the
chart  set  forth  below.  On  December 28, 2009, High River, Icahn Partners and
Icahn Master III and on January 5, 2010, Icahn Master, exercised all of the call
options  described  in  Annex  A  Attachment  1-A, and upon exercise of the call
options, all of the put options described below expired pursuant to their terms.


NAME                    DATE                  QUANTITY        OPTION PREMIUM ($)
- ----                    ----                  --------        ------------------
High River            11/04/2009             40,000.00              7,153.88
High River            11/13/2009             45,000.00              7,810.07
High River            11/16/2009            122,560.00             20,366.90
High River            11/18/2009             54,512.00              9,000.91
High River            11/24/2009             72,000.00             12,136.46
High River            11/30/2009             80,000.00             14,088.96
High River            12/02/2009              4,493.00                796.92
High River            12/03/2009             95,000.00             16,585.01
High River            12/04/2009             44,080.00              7,373.88
High River            12/07/2009             80,000.00             13,257.44
High River            12/08/2009             60,000.00              9,665.22
High River            12/09/2009             61,177.00              9,702.12
High River            12/15/2009             80,000.00             12,832.00
High River            12/16/2009            190,008.00             30,030.38
High River            12/17/2009             20,000.00              3,050.80
Icahn Partners        11/04/2009             66,516.00             11,896.19
Icahn Partners        11/13/2009             65,797.00             11,419.53
Icahn Partners        11/16/2009            179,202.00             29,779.61
Icahn Partners        11/18/2009             79,706.00             13,160.90
Icahn Partners        11/24/2009            105,273.00             17,745.03
Icahn Partners        11/30/2009            116,973.00             20,600.35
Icahn Partners        12/03/2009            123,029.00             21,478.28
Icahn Partners        12/04/2009             63,456.00             10,615.17
Icahn Partners        12/07/2009            115,164.00             19,084.75
Icahn Partners        12/08/2009             86,372.00             13,913.41
Icahn Partners        12/09/2009             88,067.00             13,966.63
Icahn Partners        12/15/2009            115,164.00             18,472.31
Icahn Partners        12/16/2009            273,527.00             43,230.40
Icahn Partners        12/17/2009             28,789.00              4,391.47
Icahn Master          11/24/2009            121,064.00             20,406.79
Icahn Master          11/30/2009            134,514.00             23,689.53
Icahn Master          12/02/2009             17,972.00              3,187.69
Icahn Master          12/03/2009            179,438.00             31,326.11
Icahn Master          12/04/2009             75,454.00             12,622.25
Icahn Master          12/07/2009            136,942.00             22,693.75
Icahn Master          12/08/2009            102,706.00             16,544.60
Icahn Master          12/09/2009            104,720.00             16,607.65
Icahn Master          12/15/2009            136,941.00             21,965.34
Icahn Master          12/16/2009            325,249.00             51,404.95
Icahn Master          12/17/2009             34,237.00              5,222.51
Icahn Master III      11/04/2009              7,239.00              1,294.67
Icahn Master III      11/13/2009             10,602.00              1,840.05
Icahn Master III      11/16/2009             28,870.00              4,797.59
Icahn Master III      11/18/2009             12,841.00              2,120.28
Icahn Master III      11/24/2009             16,961.00              2,858.98
Icahn Master III      11/30/2009             18,845.00              3,318.83
Icahn Master III      12/03/2009             21,283.00              3,715.56
Icahn Master III      12/04/2009             10,288.00              1,721.02
Icahn Master III      12/07/2009             18,672.00              3,094.29
Icahn Master III      12/08/2009             14,004.00              2,255.86
Icahn Master III      12/09/2009             14,279.00              2,264.52
Icahn Master III      12/15/2009             18,672.00              2,994.99
Icahn Master III      12/16/2009             44,348.00              7,009.11
Icahn Master III      12/17/2009              4,668.00                712.06




                                                                         ANNEX B

                          [FORM OF NOMINEE AGREEMENT]

                         HIGH RIVER LIMITED PARTNERSHIP
                               ICAHN PARTNERS LP
                         ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                       ICAHN PARTNERS MASTER FUND III LP

                               FEBRUARY 17, 2010

Dear  ___________:


     This will confirm our understanding as follows:

     You agree that you are willing, should we so elect, to become a member of a
slate  of  nominees  (the "Slate") to stand for election as directors of Genzyme
Corporation  ("Genzyme")  in  connection with a proxy contest with management of
Genzyme  in  respect  of the election of directors of Genzyme at the 2010 Annual
Meeting  of  Shareholders of Genzyme (the "Annual Meeting"), expected to be held
in  the  Spring  of 2010, or a special meeting of shareholders of Genzyme called
for  a  similar  purpose  (the  "Proxy  Contest").

     High  River  Limited  Partnership, Icahn Partners LP, Icahn Partners Master
Fund  LP, Icahn Partners Master Fund II LP and Icahn Partners Master Fund III LP
(collectively,  "Icahn"),  agree  to  pay  the  costs  of  the  Proxy  Contest.

     In addition, upon our filing of a preliminary proxy statement with the SEC,
which  indicates  that  Icahn intends to nominate you for election at the Annual
Meeting, you will be entitled to be paid $25,000 by Icahn unless you are elected
to  serve as a director of Genzyme at the Annual Meeting or a special meeting of
shareholders  of  Genzyme  called  for a similar purpose or in connection with a
settlement of the Proxy Contest by Icahn and Genzyme, in which case you will not
receive  any payment from Icahn in connection with the Proxy Contest. Payment to
you  pursuant  to  this paragraph, if any, will be made by Icahn, subject to the
terms  hereof,  upon the earliest of (i) the certification of the results of the
election  in  respect  of  the  Proxy  Contest, (ii) the settlement of the Proxy
Contest  by  Icahn  and Genzyme, or (iii) the withdrawal of the Proxy Contest by
Icahn. (7)

     You  understand  that  it  may  be difficult, if not impossible, to replace
nominees  who,  such  as  yourself,  have agreed to serve on the Slate and later
change their minds and determine not to seek election. Accordingly, the Slate is
relying  upon your agreement to seek election. In that connection, you are being
supplied  with  a questionnaire in which you will provide Icahn with information
necessary  for  Icahn to make appropriate disclosure both to Genzyme and for use
in  creating  the proxy material to be sent to shareholders of Genzyme and to be
filed  with the Securities and Exchange Commission. You have agreed that (i) you
will  immediately  complete  and sign the questionnaire and return it to Tara L.
Keating,  Assistant  General  Counsel,  Icahn  Enterprises LP, 767 Fifth Avenue,
Suite 4700, New York, NY 10153, Tel: (212) 702-4365, Fax: (212) 688-1158, Email:
tkeating@sfire.com  and  (ii)  your responses to the questions contained therein
will  be  true  and  correct in all respects. In addition, you have agreed that,
concurrently  with  your execution of this letter, you will execute the attached
instrument  directed  to  Genzyme  informing  Genzyme  that you consent to being
nominated  by  Icahn  for  election  as  a  director of Genzyme and, if elected,
consent  to  serving  as a director of Genzyme. Upon being notified that we have
chosen  you,  we  may  forward that consent and your completed questionnaire (or
summaries  thereof)  to  Genzyme.

________________________
(7)  This paragraph is not contained in Dr. Denner's Nominee Agreement.





     Icahn hereby agrees that, so long as you actually serve on the Slate, Icahn
will  defend,  indemnify  and  hold  you  harmless  from and against any and all
losses,  damages, penalties, judgments, awards, liabilities, costs, expenses and
disbursements (including, without limitation, reasonable attorneys' fees, costs,
expenses  and  disbursements) incurred by you in the event that (i) you become a
party,  or  are  threatened  to  be  made  a  party,  to  any  civil,  criminal,
administrative or arbitrative action, suit or proceeding, and any appeal thereof
relating  solely  to your role as a nominee for director of Genzyme on the Slate
(a  "Proceeding")  or (ii) you are called to testify or give a deposition in any
Proceeding  (whether or not you are a party or are threatened to be made a party
to  such  Proceeding),  including,  in  each case, the advancement to you of all
reasonable  attorneys' costs and expenses incurred by you in connection with any
Proceeding.  Your  right  of indemnification hereunder shall continue (i) in the
event  that  Icahn determines to withdraw the Slate or remove you from the Slate
and  (ii)  after  the  election  has taken place but only for events which occur
prior  to  such  election  and  subsequent  to  the date hereof. Anything to the
contrary  herein  notwithstanding,  Icahn is not indemnifying you for any action
taken  by  you  or  on  your  behalf  which  occurs  prior to the date hereof or
subsequent  to  the  Annual  Meeting or such earlier time as you are no longer a
nominee  of  the  Slate  for election to Genzyme's Board of Directors or for any
actions  taken  by  you  as  a  director of Genzyme, if you are elected. Nothing
herein  shall be construed to provide you an indemnity: (i) in the event you are
found to have engaged in a violation of any provision of state or federal law in
connection  with  the  Proxy Contest unless you demonstrate that your action was
taken  in  good  faith  and  in a manner you reasonably believed to be in or not
opposed  to  the best interests of electing the Slate; or (ii) if you acted in a
manner  which  constitutes  gross negligence or willful misconduct. In the event
that  you shall make any claim for indemnification hereunder, you shall promptly
notify Icahn in the event of any third-party claims actually made against you or
known  by  you  to  be  threatened. In addition, with respect to any such claim,
Icahn  shall  be  entitled to control your defense with counsel chosen by Icahn.
Icahn  shall  not  be  responsible  for  any settlement of any claim against you
covered  by this indemnity without its prior written consent. However, Icahn may
not enter into any settlement of any such claim without your consent unless such
settlement  includes  a  release of you from any and all liability in respect of
such  claim.

     Each  of us recognizes that should you be elected to the Board of Directors
of  Genzyme  all of your activities and decisions as a director will be governed
by  applicable  law  and  subject  to your fiduciary duty to the shareholders of
Genzyme  and,  as  a result, that there is, and can be, no agreement between you
and  Icahn  which  governs  the  decisions  which you will make as a director of
Genzyme.

     Should  the  foregoing agree with your understanding, please so indicate in
the  space provided below, whereupon this letter will become a binding agreement
between  us.

                                          Very  truly  yours,

                                          HIGH  RIVER  LIMITED  PARTNERSHIP


                                          By:  __________________________
                                               Name:  Edward  E.  Mattner
                                               Title:  Authorized  Signatory


                                          ICAHN  PARTNERS  LP


                                          By:  __________________________
                                               Name:  Edward  E.  Mattner
                                               Title:  Authorized  Signatory

                                          ICAHN  PARTNERS  MASTER  FUND  LP


                                          By:  __________________________
                                               Name:  Edward  E.  Mattner
                                               Title:  Authorized  Signatory

                                          ICAHN  PARTNERS  MASTER  FUND  II  LP


                                          By:  __________________________
                                               Name:  Edward  E.  Mattner
                                               Title:  Authorized  Signatory

                                          ICAHN  PARTNERS  MASTER  FUND  III  LP


                                          By:  __________________________
                                               Name:  Edward  E.  Mattner
                                               Title:  Authorized  Signatory

Agreed  to  and  Accepted  as
of  the  date  first  above  written:

__________________________
Name:




                                   IMPORTANT
                                   ---------

     1.  If  your shares of Common Stock are held in your own name, please mark,
date  and  mail the enclosed GOLD proxy card to our Proxy Solicitor, D.F. King &
Co.,  Inc.,  in  the  postage-paid  envelope  provided.

     2. If your shares of Common Stock are held in the name of a brokerage firm,
bank  nominee or other institution, only it can vote such shares of Common Stock
and  only  upon  receipt  of your specific instructions. Accordingly, you should
contact the person responsible for your account and give instructions for a GOLD
proxy  card  to  be  signed  representing  your  shares  of  Common  Stock.

     3.  If  you  have  already  submitted a white proxy card to Genzyme for the
Annual  Meeting,  you  may  change  your  vote to a vote FOR the election of the
Nominee  by  marking, signing, dating and returning the enclosed GOLD proxy card
for  the  Annual  Meeting,  which  must  be  dated  after any proxy you may have
submitted  to  Genzyme.  You may also submit your later-dated proxy by using the
enclosed  GOLD  proxy card to vote by telephone or by Internet. ONLY YOUR LATEST
DATED  PROXY  FOR  THE  ANNUAL  MEETING  WILL  COUNT  AT  THE  ANNUAL  MEETING.

     If  you  have  any  questions  or  require any assistance in executing your
proxy,  please  call:

                             D.F. KING & CO., INC.
                  STOCKHOLDERS CALL TOLL-FREE:  (800) 347-4750
                BANKS AND BROKERAGE FIRMS CALL:  (212) 269-5550




            [PRELIMINARY COPY OF PROXY CARD, SUBJECT TO COMPLETION]

                              GENZYME CORPORATION
                         ANNUAL MEETING OF SHAREHOLDERS
                                 JUNE 16, 2010
GOLD PROXY CARD                                                  GOLD PROXY CARD


                          THIS PROXY IS SOLICITED BY:
DR.  STEVEN  BURAKOFF,  DR.  ALEXANDER J. DENNER, MR. CARL C. ICAHN, DR. RICHARD
MULLIGAN, DR. ERIC ENDE, HIGH RIVER LIMITED PARTNERSHIP, HOPPER INVESTMENTS LLC,
BARBERRY CORP., ICAHN PARTNERS LP, ICAHN PARTNERS MASTER FUND LP, ICAHN PARTNERS
MASTER  FUND  II  LP,  ICAHN PARTNERS MASTER FUND III LP, ICAHN ENTERPRISES G.P.
INC.,  ICAHN  ENTERPRISES  HOLDINGS  L.P., IPH GP LLC, ICAHN CAPITAL L.P., ICAHN
ONSHORE  LP,  ICAHN  OFFSHORE  LP  AND  BECKTON  CORP.  (THE  "PARTICIPANTS")

                                                         VOTING  CONTROL  NUMBER

        THERE ARE THREE WAYS TO AUTHORIZE THE PROXIES TO CAST YOUR VOTES
      YOUR TELEPHONE OR INTERNET VOTE AUTHORIZES THE NAMED PROXIES TO VOTE
     YOUR SHARES IN THE SAME MANNER AS IF YOU HAD RETURNED YOUR PROXY CARD.
      WE ENCOURAGE YOU TO USE THESE COST EFFECTIVE AND CONVENIENT WAYS OF
                     VOTING, 24 HOURS A DAY, 7 DAYS A WEEK.

TELEPHONE VOTING               INTERNET VOTING               VOTING BY MAIL
This method of voting is      Visit the Internet voting    Simply sign and date
available for residents of    Web site at http:// [ ].     your proxy card and
the U.S. and Canada. On a     Have this proxy card ready   and return it in the
touch tone telephone, call    and follow the instructions  postage-paid envelope
TOLL FREE [ ], 24 hours a     on your screen. You will     to [  ].  If you are
day, 7 days a week. Have      incur only your usual        voting by telephone
this proxy card ready, then   Internet charges. Available  or the Internet,
follow the prerecorded        24 hours a day, 7 days a     please do not mail
instructions. Your vote       week until [ ] p.m.          your proxy card.
will be confirmed and cast    Eastern Daylight Time on
as you have directed.         [ ] 2010.
Available 24 hours a day, 7
days a week until [ ] p.m.
Eastern Daylight Time on
[ ] , 2010.

                   DETACH BELOW AND RETURN USING THE ENVELOPE
                    PROVIDED ONLY IF YOU ARE VOTING BY MAIL.


           YOUR VOTE, WHETHER BY INTERNET, TELEPHONE OR MAIL, MUST BE
        RECEIVED NO LATER THAN [ ] TO BE INCLUDED IN THE VOTING RESULTS.
                                  DETACH HERE


            [PRELIMINARY COPY OF PROXY CARD, SUBJECT TO COMPLETION]

                              GENZYME CORPORATION
                         ANNUAL MEETING OF SHAREHOLDERS
                                 JUNE 16, 2010
GOLD PROXY CARD                                                  GOLD PROXY CARD
                          THIS PROXY IS SOLICITED BY:
DR.  STEVEN  BURAKOFF,  DR.  ALEXANDER J. DENNER, MR. CARL C. ICAHN, DR. RICHARD
MULLIGAN,  DR.  ERIC  ENDE,  HIGH  RIVER LIMITED PARTNERSHIP, HOPPER INVESTMENTS
LLC,BARBERRY  CORP.,  ICAHN  PARTNERS  LP,  ICAHN PARTNERS MASTER FUND LP, ICAHN
PARTNERS MASTER FUND II LP, ICAHN PARTNERS MASTER FUND III LP, ICAHN ENTERPRISES
G.P.  INC.,  ICAHN  ENTERPRISES  HOLDINGS  L.P., IPH GP LLC, ICAHN CAPITAL L.P.,
ICAHN  ONSHORE  LP,  ICAHN  OFFSHORE  LP  AND BECKTON CORP. (THE "PARTICIPANTS")


The  undersigned hereby appoints and constitutes each of Alexander J. Denner and
[  ]  (acting  alone or together) as proxies, with full power of substitution in
each,  to  represent  the  undersigned  at the Annual Meeting of Shareholders of
Genzyme Corporation ("Genzyme") to be held on June 16, 2010 at 9 a.m. local time
at  the  American  Academy  of  Arts and Sciences, 136 Irving Street, Cambridge,
Massachusetts,  and  at any adjournment or postponement or continuations thereof
(the  "Annual  Meeting"),  hereby revoking any proxies previously given, to vote
all  shares  of  Common  Stock  of  Genzyme  held or owned by the undersigned as
directed  below,  and  in  their  discretion upon such other matters as may come
before  the  meeting  (provided,  however,  that the persons named above will be
permitted to use such discretionary authority only for matters which they do not
know,  a  reasonable  time  before  the solicitation, are to be presented at the
meeting).

  IF  NO  DIRECTION  IS  MADE,  THE  PERSONS  NAMED  IN  THIS GOLD PROXY CARD
  WILL  VOTE YOUR SHARES: (I) FOR DR. STEPHEN BURAKOFF FOR DIRECTOR; (II) FOR
  DR.  ALEXANDER  J.  DENNER  FOR  DIRECTOR;  (III) FOR MR. CARL C. ICAHN FOR
  DIRECTOR (IV) FOR DR. RICHARD MULLIGAN FOR DIRECTOR (V) FOR THE PERSONS WHO
  HAVE  BEEN NOMINATED BY GENZYME TO SERVE AS DIRECTORS, OTHER THAN [ ]; (VI)
  [  ]  THE  AMENDMENT  TO  THE  2004  EQUITY  INCENTIVE  PLAN; (VII) [ ] THE
  AMENDMENT  TO  THE  2009  EMPLOYEE  STOCK  PURCHASE  PLAN;  (VIII)  [ ] THE
  AMENDMENT  TO  THE  2007 DIRECTOR EQUITY PLAN; (IX) [ ]THE AMENDMENT TO THE
  RESTATED ARTICLES OF ORGANIZATION; (X) [ ]THE RATIFICATION OF THE SELECTION
  OF  THE  INDEPENDENT  REGISTERED  ACCOUNTING  FIRM;  AND  (XI) IN THE PROXY
  HOLDERS'  DISCRETION  AS TO OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE
  ANNUAL  MEETING.

    THE PROXY STATEMENT, AS WELL AS OTHER PROXY MATERIALS DISTRIBUTED BY THE
  PARTICIPANTS, ARE AVAILABLE FREE OF CHARGE ONLINE AT WWW.DFKING.COM/GENZYME.
 SIGN, DATE AND MAIL YOUR PROXY TODAY UNLESS YOU HAVE VOTED BY TELEPHONE OR BY
          INTERNET, (CONTINUED AND TO BE SIGNED ON THE REVERSE SIDE.)



  IF YOU HAVE NOT VOTED BY INTERNET OR TELEPHONE, PLEASE DATE, MARK, SIGN AND
RETURN THIS PROXY PROMPTLY.  YOUR VOTE, WHETHER BY INTERNET, TELEPHONE OR MAIL,
  MUST BE RECEIVED NO LATER THAN [  ]  TO BE INCLUDED IN THE VOTING RESULTS.



            [PRELIMINARY COPY OF PROXY CARD, SUBJECT TO COMPLETION]

[X]  PLEASE MARK VOTES AS IN THIS EXAMPLE.

THE PARTICIPANTS RECOMMEND A VOTE "FOR" THE ELECTION OF THE NOMINEES LISTED IN
PROPOSAL 1 BELOW AND PROPOSALS [ ].

1.  Election of directors -- Nominees:     [ ]             [ ]             [ ]
    (01) Dr. Steven  Burakoff              FOR ALL    WITHHELD FROM      FOR ALL
    (02) Dr. Alexander  J.  Denner         NOMINEES   ALL NOMINEES       EXCEPT
    (03) Mr. Carl  C.  Icahn
    (04) Dr. Richard  Mulligan

    The persons who have been nominated by Genzyme to serve as directors, [ ].

     The  Participants  are  NOT  seeking  authority  to  vote  for and WILL NOT
     exercise  any  authority to vote for [ ]. There is no assurance that any of
     the Genzyme nominees, will serve as directors if any or all of the Nominees
     are  elected to the Board. You should refer to the proxy statement and form
     of  proxy distributed Genzyme for the names, background, qualifications and
     other  information  concerning  Genzyme  nominees.

     NOTE:  IF  YOU  DO  NOT  WISH YOUR SHARES VOTED "FOR" A PARTICULAR NOMINEE,
     MARK  THE  "FOR ALL EXCEPT" BOX AND WRITE THE NAME(S) OF THE NOMINEE(S) YOU
     DO  NOT  SUPPORT ON THE LINE BELOW. YOU MAY ALSO WITHHOLD AUTHORITY TO VOTE
     FOR  THE  PERSONS  WHO HAVE BEEN NOMINATED BY GENZYME TO SERVE AS DIRECTORS
     OTHER  THAN  [  ]  BY WRITING THE NAMES OF SUCH NOMINEES BELOW. YOUR SHARES
     WILL  THEN BE  VOTED  FOR  THE  REMAINING  NOMINEE(S).

     ___________________________________________________________________________

2.  A proposal to amend the 2004 Equity            [ ]       [ ]          [ ]
    Incentive Plan to increase the number          FOR     AGAINST      ABSTAIN
    of shares of common stock available
    for issuance under the plan by
    2,750,000  shares.

3.  A proposal to amend the 2009 Employee          [ ]       [ ]          [ ]
    Stock Purchase Plan to increase the            FOR     AGAINST      ABSTAIN
    number of shares of common stock under
    the  plan  by  1,500,000.

4.  A proposal to amend the 2007 Director          [ ]       [ ]          [ ]
    Equity Plan to increase the number of          FOR     AGAINST      ABSTAIN
    shares of common stock available for
    issuance under the plan by 250,000
    shares.

5.  A proposal to amend the Restated               [ ]       [ ]          [ ]
    Articles of Organization to reduce the         FOR     AGAINST      ABSTAIN
    percentage of shares required for
    shareholders to call a special meeting
    of shareholders from 90% to 40%.

6.  A proposal to ratify the audit committee's     [ ]       [ ]          [ ]
    selection of independent auditors for 2010.    FOR     AGAINST      ABSTAIN


    Please  be  sure  to  sign  and  date  this  Proxy.


          -------------------------------------       --------------------------
          SIGNATURE(S)  OF  SHAREHOLDER(S)               DATE


          -------------------------------------       --------------------------
          SIGNATURE(S)  IF  HELD  JOINTLY                DATE


          ----------------------------------------------------------------------
          TITLE,  IF  ANY