Exhibit 16.1


November 28, 2000

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549

Commissioners:

We have read the statements made by IGI, Inc. (copy attached), which we
understand will be filed with the Commission, pursuant to Item 4 of Form 8-
K, as part of the Company's Form 8-K report dated November 28, 2000. We
agree with the statements concerning our Firm in such Form 8-K.

Very truly yours,



PricewaterhouseCoopers LLP