EXHIBIT 4.3


               PATENT COLLATERAL ASSIGNMENT AND SECURITY AGREEMENT
               ---------------------------------------------------


     AGREEMENT  made this 17th day of  September,  2002 by and between  AMERICAN
BIOGENETIC  SCIENCES,  INC., a Delaware corporation  ("DEBTOR"),  with its chief
executive office at 1375 Akron Street,  Copiague,  New York 11726, and ALFRED J.
ROACH,  an  individual   ("SECURED   PARTY"),   residing  at  207  Inlet  Drive,
Lindenhurst, New York 11757.

                              W I T N E S S E T H:

     WHEREAS,  Debtor has  adopted,  used and is using,  and is the owner of the
entire  right,  title,  and  interest  in and to the  patents  and  applications
therefor described in Exhibit A annexed hereto and made a part hereof; and

     WHEREAS,  Secured  Party  is  contemporaneously  herewith  making a loan to
Debtor in the principal amount of $75,000 pursuant to a certain  Promissory Note
of even date herewith (as same may be amended, modified, supplemented, extended,
renewed,  restated or replaced,  the "NOTE"),  and may, but is not obligated to,
make  additional  loans to, and/or provide other financial  accommodations  for,
Debtor in the future; and

     WHEREAS, in order to induce Secured Party to make the loan evidenced by the
Note and, if mutually determined among the parties, make other loans or advances
to, and/or provide other  financial  accommodations  for,  Debtor in the future,
Debtor has agreed to grant to Secured Party certain  collateral  security as set
forth herein;

     NOW,  THEREFORE,  in  consideration  of the premises and for other good and
valuable  consideration,  the  receipt  and  sufficiency  of  which  are  hereby
acknowledged, Debtor hereby agrees as follows:

     1.   GRANT OF SECURITY INTEREST
          --------------------------

     As  collateral  security  for  the  prompt   performance,   observance  and
indefeasible payment in full of all of the Obligations (as hereinafter defined),
Debtor hereby grants to Secured Party a continuing  security  interest in, and a
general lien upon,  and hereby  assigns to Secured Party all of Debtor's  right,
title  and  interest  in and to the  following,  in  each  case  whether  now or
hereafter  existing or in which Debtor now has or hereafter acquires an interest
and wherever the same may be located (the "COLLATERAL"):

          (a) the patents, applications,  registrations and recordings described
in Exhibit A hereto in the United States  Patent and Trademark  Office or in any
similar office or agency of the United States, any State thereof,  any political
subdivision thereof or in any other countries, and all reissues,  extensions and
renewals  thereof,  all  rights  (but  not  obligations)  corresponding  thereto
(including  without  limitation  the right (but not the  obligation)  to sue for
past,  present and future  infringements in the name of Debtor or in the name of
Secured Party (the "PATENTS"),  it being understood that the rights and interest
assigned hereby shall include, without limitation, all



rights  and  interests   pursuant  to  licensing or other  contracts in favor of
Debtor pertaining to the Patents;

          (b) all general intangibles relating to the Patents;

          (c) all books, records, ledger cards, files, correspondence,  computer
programs,  tapes,  disks and related data  processing  software that at any time
evidence  or  contain  information  relating  to any of  the  Collateral  or are
otherwise  necessary  or  helpful  in  the  collection  thereof  or  realization
thereupon; and

          (d) all  proceeds,  products,  rents and  profits  (including  without
limitation license royalties and proceeds of infringement  suits) of or from any
and all of the foregoing  Collateral and, to the extent not otherwise  included,
all payments  under  insurance  (whether or not Secured  Party is the loss payee
thereof), or any indemnity,  warranty or guaranty,  payable by reason of loss or
damage to or otherwise with respect to any of the foregoing Collateral.

     In addition to, and not by way of limitation of, the granting of a security
interest in the Collateral  pursuant to this Section,  Debtor hereby,  effective
upon the  occurrence  of an Event of Default (as  hereinafter  defined) and upon
written notice from Secured Party, grants,  sells, conveys,  transfers,  assigns
and sets over to Secured Party, all of Debtor's right, title and interest in and
to the Collateral.

     2.   OBLIGATIONS SECURED
          -------------------

     The security  interest,  lien and other interests  granted to Secured Party
pursuant to this Agreement shall secure the prompt  performance,  observance and
indefeasible payment in full of any and all loans, indebtedness, liabilities and
obligations of any kind owing by Debtor to Secured Party  (including the payment
of amounts that would become due but for the  operation  of the  automatic  stay
under  Section  362(a) of the  Bankruptcy  Code, 11 U.S.C.(S)  362(a)),  and all
extensions  or renewals  thereof,  whether for  principal,  interest  (including
without limitation interest that, but for the filing of a petition in bankruptcy
with respect to Debtor,  would accrue on such  obligations),  however evidenced,
whether as principal,  guarantor or otherwise, whether arising under the Note or
otherwise, whether direct or indirect, absolute or contingent, joint or several,
secured or  unsecured,  due or not due,  primary  or  secondary,  liquidated  or
unliquidated,  original,  renewed  or  extended,  whether  arising  directly  or
acquired from others and including, without limitation, Secured Party's charges,
commissions,  interest, expenses, costs and attorneys' fees chargeable to Debtor
under  this  Agreement,  the Note or in  connection  with  any of the  foregoing
(including the payment of amounts that would become due but for the operation of
the automatic  stay under Section  362(a) of the  Bankruptcy  Code, 11 U.S.C.(S)
362(a)), and all



                                      -2-



extensions  or renewals  thereof,  whether for  principal,  interest  (including
without limitation interest that, but for the filing of a petition in bankruptcy
with respect to Debtor,  would  accrue on such  obligations),  (all  hereinafter
referred to as "OBLIGATIONS").

     3.   REPRESENTATIONS, WARRANTIES AND COVENANTS
          -----------------------------------------

     Debtor hereby  represents,  warrants and covenants (which shall survive the
execution and delivery of this Agreement) to Secured Party that:

          (a) Debtor will pay and perform all of the  Obligations  according  to
their terms.

          (b) The chief place of business and chief  executive  office of Debtor
and the  office  where  Debtor  keeps  its  books  and  records  concerning  the
Collateral are located at the address first specified above for Debtor.

          (c) Debtor  conducts,  and for the past five years has  conducted,  no
business  under any name,  fictitious  name, or trade name,  other than American
Biogenetic  Sciences,  Inc. which is Debtor's legal name.  Debtor's  federal tax
identification number is 11-2655906.

          (d) Debtor has exclusive possession and control of all Collateral.

          (e) All corporate  action  required to authorize  Debtor's  execution,
delivery and performance of this Agreement has been duly and validly taken.

          (f) Not change its jurisdiction of incorporation or organization.

          (g) All of the existing  Collateral  is valid and  subsisting  in full
force and effect,  and Debtor owns the sole, full, and clear title thereto,  and
the right and power to grant the security  interests granted  hereunder.  Debtor
will, at Debtor's expense,  perform all acts and execute all documents necessary
to maintain the existence of the Collateral as valid,  subsisting and registered
patents including,  without limitation, the filing of any renewal affidavits and
applications.  The  Collateral is not subject to any liens,  claims,  mortgages,
assignments,  licenses,  security  interests,  or  encumbrances  of  any  nature
whatsoever,  except the security  interests  granted  hereunder and the licenses
permitted under Section 3(k).

          (h) Debtor will not assign, sell, mortgage,  lease, transfer,  pledge,
hypothecate,  grant a  security  interest  in or lien upon,  encumber,  grant an
exclusive  or  non-exclusive  license  relating  to the  Collateral,  except  as
permitted  herein,  or otherwise  dispose of any of the  Collateral  without the
prior  written  consent of Secured  Party.  Nothing in this  Agreement  shall be
deemed a consent by Secured  Party to any such action,  except as such action is
expressly permitted hereunder.



                                      -3-


          (i) Debtor will, at Debtor's expense, perform all acts and execute all
documents requested at any time by Secured Party to evidence, perfect, maintain,
record, or enforce the security interest in the Collateral  granted hereunder or
to otherwise further the provisions of this Agreement.  Debtor hereby authorizes
Secured Party to execute and file one or more  financing  statements (or similar
documents)  with respect to the  Collateral  signed only by Secured  Party or as
otherwise  determined by Secured Party.  Debtor further authorizes Secured Party
to file  financing  statements  and/or have this or any other  similar  security
agreement  filed  with the  Commissioner  of  Patents  and  Trademarks  or other
appropriate federal, state or government office.

          (j) This Agreement,  together with the filing of a financing statement
describing the  Collateral  with the Secretary of State of the State of Delaware
and the recording of this  Agreement with the United States Patent and Trademark
Office,  which  will be made,  creates a valid,  perfected  and  first  priority
security  interest in the Collateral,  securing the payment of the  Obligations,
and all other  filings and other  actions  necessary or desirable to perfect and
protect such security  interest have been or will be duly made or taken.  Except
therefor,  all actions  necessary to perfect and protect the  security  interest
created hereby have been duly taken. Except for the foregoing, no authorization,
approval or other action by, and no notice to or filing with,  any  governmental
authority or any other person is required  either (i) for the grant by Debtor of
the  security  interest  granted  hereby  or  for  the  execution,  delivery  or
performance  of this  Agreement by Debtor or (ii) for the  perfection  of or the
exercise by Secured Party of its rights and remedies hereunder.

          (k) Debtor has not granted  any  licenses  with  respect to any of the
Collateral other than as set forth on Exhibit C hereto.

          (l) Debtor will,  concurrently with the execution and delivery of this
Agreement,  execute and deliver to Secured Party five (5) originals of a Special
Power of Attorney in the form of Exhibit B annexed hereto for the implementation
of the  assignment,  sale or other  disposition  of the  Collateral  pursuant to
Secured  Party's  exercise of the rights and remedies  granted to Secured  Party
hereunder.

          (m) Debtor shall not file any  application  for the  registration of a
Patent with the United States Patent and Trademark  Office or any similar office
or agency in the United States, any state therein, or any other country,  unless
Debtor has by thirty (30) days prior written  notice  informed  Secured Party of
such action.  Upon request of Secured Party, Debtor shall execute and deliver to
Secured Party any and all assignments,  agreements,  instruments, documents, and
such other papers as may be requested by Secured  Party to evidence the security
interests of Secured Party in such Patent.



                                      -4-


          (o) Debtor has not abandoned any of the Patents and Debtor will not do
any act,  nor omit to do any act,  whereby  the  Patents  may become  abandoned,
invalidated,  unenforceable,  avoided, or avoidable. Debtor shall notify Secured
Party  immediately  if it  knows or has  reason  to know of any  reason  why any
application,   registration,  or  recording  may  become  abandoned,   canceled,
invalidated, avoided, or avoidable.

          (p) Debtor will render all  assistance  necessary to Secured  Party in
any proceeding before the United States Patent and Trademark Office, any federal
or state  court,  or any  similar  office or agency in the United  States or any
state therein or any other country to maintain such application and registration
of the Patents as Debtor's  exclusive  property and to protect  Secured  Party's
interest therein, including, without limitation,  filing of renewals, affidavits
of  use,  affidavits  of  incontestability  and  opposition,  interference,  and
cancellation proceedings.

          (q)  Debtor  will  promptly  notify  Secured  Party if Debtor  (or any
affiliate or  subsidiary  thereof)  learns of any use by any person of any other
process or product  which  infringes  upon any Patent.  If  requested by Secured
Party, Debtor, at Debtor's expense, shall join with Secured Party in such action
as Secured  Party,  in Secured  Party's  discretion,  may deem advisable for the
protection of Secured Party's interest in and to the Patents.

          (r) Debtor assumes all  responsibility  and liability arising from the
use of the  Patents  and  Debtor  hereby  indemnifies  and holds  Secured  Party
harmless from and against any claim,  suit, loss,  damage, or expense (including
attorneys' fees) arising out of any alleged defect in any product  manufactured,
promoted,  or sold by  Debtor  (or  any  affiliate  or  subsidiary  thereof)  in
connection with any Patent or out of the manufacture,  promotion, labeling, sale
or  advertisement  of any such product by Debtor (or any affiliate or subsidiary
thereof).

          (s) Debtor will  promptly pay Secured  Party for any and all costs and
reasonable  expenditures incurred by Secured Party pursuant to the provisions of
this  Agreement  or  for  the  defense,   protection,   or  enforcement  of  the
Obligations,  the  Collateral,  or the  security  interests  granted  hereunder,
including,  but not  limited  to, all filing or  recording  fees,  court  costs,
collection  charges,  travel expenses,  and attorneys' fees and reasonable legal
expenses.  Such costs and  reasonable  expenditures  shall be payable on demand,
together  with  interest at the then  applicable  rate set forth in the Note and
shall be part of the Obligations secured hereby.

     4.   EVENTS OF DEFAULT
          -----------------

     All Obligations shall become immediately due and payable, without notice or
demand,  at the option of Secured Party,  upon the occurrence of any one or more
Events of Default under the Note (each an "EVENT OF DEFAULT" hereunder).



                                      -5-


     5.   RIGHTS AND REMEDIES
          -------------------

     Upon the occurrence of any such Event of Default and during the continuance
thereof, in addition to all other rights and remedies of Secured Party,  whether
provided  under  law,  the  Note or  otherwise,  Secured  Party  shall  have the
following  rights and  remedies  which may be  exercised  without  notice to, or
consent by,  Debtor  except as such notice or consent is expressly  provided for
hereunder:

          (a) Secured Party may require that neither Debtor nor any affiliate or
subsidiary  of Debtor make any use of the  Patents  for any purpose  whatsoever.
Secured  Party may make use of any Patents for the sale of goods,  completion of
work-in-process  or  rendering  of  services or  otherwise  in  connection  with
enforcing any other security  interest granted to Secured Party by Debtor or any
subsidiary or affiliate of Debtor.

          (b) Secured  Party may grant such license or licenses  relating to the
Collateral for such term or terms, on such  conditions,  and in such manner,  as
Secured Party shall in its discretion deem appropriate. Such license or licenses
may be general,  special,  or  otherwise,  and may be granted on an exclusive or
non-exclusive  basis throughout all or any part of the United States of America,
its territories and possessions, and all foreign countries.

          (c)  Secured  Party may  assign,  sell,  or  otherwise  dispose of the
Collateral or any part  thereof,  either with or without  special  conditions or
stipulations  except  that if  notice  to  Debtor  of  intended  disposition  of
Collateral is required by law, the giving of five (5) business days prior notice
in the manner  set forth in  Section  10(d)  hereof  shall be deemed  reasonable
notice thereof and Debtor waives any other notice with respect thereto.  Secured
Party  shall  have the  power to buy the  Collateral  or any part  thereof,  and
Secured  Party shall also have the power to execute  assurances  and perform all
other acts which  Secured  Party may, in its  discretion,  deem  appropriate  or
proper to complete such assignment, sale, or disposition.

          (d) Upon written demand from Secured  Party,  Debtor shall execute and
deliver to Secured Party an assignment  or  assignments  of the Patents and such
other  documents  as are  necessary or  appropriate  to carry out the intent and
purposes of this  Agreement;  provided that the failure of Debtor to comply with
such demand will not impair or affect the validity of the conditional assignment
effected by the last paragraph of Section 2 or its effectiveness  upon notice by
Secured  Party as  specified in the last  paragraph of Section 2. Debtor  agrees
that such an assignment (including without limitation the conditional assignment
effected by the last paragraph of Section 2) and/or  recording  shall be applied
to reduce the  Obligations  outstanding  only to the extent that  Secured  Party
receives cash proceeds in respect of the sale of, or other realization upon, the
Collateral.



                                      -6-


          (e)  In  addition  to  the  foregoing,   in  order  to  implement  the
assignment,  sale, or other disposition of any of the Collateral pursuant to the
last  paragraph of Section 2 or Section 5(c)  hereof,  Secured  Party may at any
time execute and deliver on behalf of Debtor,  pursuant to the authority granted
in the  Powers  of  Attorney  described  in  Section 3 (h)  hereof,  one or more
instruments of assignment of the Patents (or any application,  registration,  or
recording  relating  thereto),  in  form  suitable  for  filing,  recording,  or
registration. Debtor agrees to pay Secured Party on demand all costs incurred in
any such transfer of the Collateral,  including,  but not limited to, any taxes,
fees, and reasonable attorneys' fees and legal expenses.

          (f) Secured Party may first apply the proceeds  actually received from
any such license,  assignment,  sale, or other  disposition of Collateral to the
costs and expenses thereof, including,  without limitation,  attorneys' fees and
all legal,  travel,  and other  expenses which may be incurred by Secured Party.
Thereafter,  Secured  Party  may  apply any  remaining  proceeds  to such of the
Obligations  as Secured  Party may in its  discretion  determine.  Debtor  shall
remain liable to Secured Party for any expenses or obligations  remaining unpaid
after the  application  of such  proceeds,  and Debtor will pay Secured Party on
demand any such unpaid  amount,  together  with  interest at a rate equal to the
highest rate then payable on the Obligations.

          (g)  Debtor  shall  supply  to  Secured  Party or to  Secured  Party's
designee,  Debtor's knowledge and expertise relating to the manufacture and sale
of the products and services to which the Patents  relate and Debtor's  customer
lists and other records relating to the Patents and the distribution thereof.

         Nothing  contained herein shall be construed as requiring Secured Party
to take any such action at any time. All of Secured Party's rights and remedies,
whether  provided  under law, this  Agreement,  the Note or otherwise,  shall be
cumulative  and none is  exclusive.  Such  rights and  remedies  may be enforced
alternatively, successively, or concurrently.

     6.   SECURED PARTY APPOINTED ATTORNEY-IN-FACT.
          -----------------------------------------

     Debtor hereby irrevocably appoints Secured Party Debtor's attorney-in-fact,
with full  authority in the place and stead of Debtor and in the name of Debtor,
after the  occurrence of an Event of Default,  to take any action and to execute
any instrument which Secured Party may deem necessary or advisable to accomplish
the  purposes  of  this  Agreement,  including,  without  limitation,  (a)  file
financing  statements (and similar  documents) and file or record this Agreement
with the Secretary of State of the State of Delaware and with any other federal,
state or foreign government or agency to evidence,  perfect, maintain, record or
enforce the security  interest  and lien in the  Collateral  granted  hereunder,
including  without  limitation,  recording this Agreement with the United States
Patent and Trademark  Office,  (b) to ask, demand,  collect,  sue for,  recover,
compromise,  receive and give  acquittance  and  receipts  for moneys due and to
become due under or in respect of any of the Collateral,  (c) to file any claims
or take any action or institute  any  proceedings  which  Secured Party may deem
necessary or desirable for the


                                      -7-


protection  of any of the  Collateral  or  otherwise  to  enforce  the rights of
Secured Party with respect to any of the Collateral, (d) to pay or discharge any
taxes, liens, or other encumbrances at any time levied,  placed on or threatened
against the Collateral;  and (e) generally, to otherwise do such acts and things
which  Secured Party deems  necessary or useful to protect,  preserve or realize
upon the Collateral and Secured Party's security interest therein,  in each case
as full and effectually as if Secured Party were the absolute owner thereof. The
powers conferred on Secured Party hereunder shall not impose any duty upon it to
exercise any such powers.  Neither Secured Party nor any attorney-in-fact  shall
be liable for any act or omission,  error in judgment or mistake of law provided
the same is not the result of gross  negligence  or willful  misconduct.  Debtor
hereby ratifies and approves all acts of Secured Party, as its attorney-in-fact,
and Secured Party, as its  attorney-in-fact,  will not be liable for any acts of
commission or omission, nor for any error of judgment or mistake of fact or law.
These powers,  being coupled with an interest,  are until all of the Obligations
are  indefeasibly  paid in full and this  Agreement  is  terminated.  After  the
occurrence of an Event of Default,  Debtor also authorizes Secured Party, at any
time and from time to time, to communicate in its own name with any party to any
contract,  agreement or instrument included in the Collateral with regard to the
assignment of such contract,  agreement or instrument and other matters relating
thereto. Secured Party may, but shall be under no obligation, to take any of the
foregoing  actions and Secured  Party shall have no liability or  responsibility
for any act or omission taken with respect thereto.

     7.   SECURED PARTY MAY PERFORM.

          (a) Secured Party may, in its discretion, pay any amount or do any act
which Debtor fails to pay or do as required hereunder or as requested by Secured
Party to  preserve,  defend,  protect,  maintain,  record,  amend or enforce the
Obligations,  the  Collateral,  or  the  security  interest  granted  hereunder,
including  but not  limited  to all  filing  or  recording  fees,  court  costs,
collection charges and reasonable attorneys' fees.

          (b) If Debtor fails to perform any agreement contained herein, Secured
Party may itself  perform,  or cause  performance  of, such  agreement,  and the
expenses of the incurred in connection  therewith  shall be payable by Debtor on
demand  together with interest at the then applicable rate set forth in the Note
and shall be part of the Obligations secured hereby.

     8.   SECURED PARTY'S DUTIES.
          -----------------------

          (a) The powers  conferred  on Secured  Party  hereunder  are solely to
protect Secured Party's interest in the Collateral and shall not impose any duty
upon it to exercise any such powers. Secured Party shall not have any duty as to
any  Collateral  or as to the taking of any necessary  steps to preserve  rights
against prior parties or any other Person pertaining to any Collateral.




                                      -8-


          (b) Anything  contained  herein to the contrary  notwithstanding,  (i)
Debtor shall remain liable under any contracts  and  agreements  included in the
Collateral,  to the extent set forth  therein,  to perform all of its duties and
obligations  thereunder  to the same  extent as if this  Agreement  had not been
executed,  (ii) the  exercise  by Secured  Party of any of its rights  hereunder
shall  not  release  Debtor  from any of its  duties  or  obligations  under the
contracts and  agreements  included in the  Collateral,  and (iii) Secured Party
shall not have any  obligation or liability  under any contracts and  agreements
included in the Collateral by reason of this Agreement,  nor shall Secured Party
be obligated to perform any of the obligations or duties of Debtor thereunder or
to take any  action  to  collect  or  enforce  any claim  for  payment  assigned
hereunder.

     9.   INDEMNITY AND EXPENSES.
          -----------------------

         Debtor  agrees to indemnify  Secured Party from and against any and all
claims,  losses and liabilities  growing out of or resulting from this Agreement
(including, without limitation, enforcement of this Agreement). Debtor will upon
demand  pay to  Secured  Party the  amount of any and all  reasonable  expenses,
including  the fees and  out-of-pocket  disbursements  of its counsel and of any
experts and agents,  which Secured Party may incur in connection with (i) filing
or recording fees incurred in connection with this Agreement,  (ii) the custody,
preservation,  use or operation  of, or the sale of,  collection  from, or other
realization  upon, any of the  Collateral,  (iii) the exercise or enforcement of
any of the rights of Secured Party  hereunder,  or (iv) the failure by Debtor to
perform or observe any of the provisions hereof.

     10.  MISCELLANEOUS
          -------------

          (a)  Any  failure  or  delay  by  Secured  Party  to  require   strict
performance  by  Debtor  of  any  of  the  provisions,  warranties,  terms,  and
conditions contained herein or in any other agreement,  document, or instrument,
shall not  affect  Secured  Party or  Secured  Party's  right to  demand  strict
compliance and  performance  therewith,  and any waiver of any default shall not
waive or affect any other  default,  whether  prior or subsequent  thereto,  and
whether of the same or of a different type. None of the warranties,  conditions,
provisions,  and terms contained herein or in any other agreement,  document, or
instrument  shall be  deemed  to have been  waived  by any act or  knowledge  of
Secured Party, its agents,  officers, or employees, but only by an instrument in
writing,  signed  by an  officer  of  Secured  Party  and  directed  to  Debtor,
specifying such waiver.

          (b) No provision  hereof shall be modified,  altered or limited except
by a written  instrument  expressly  referring to this  Agreement  signed by the
party to be charged thereby.

          (c) In the  event  that any  provision  hereof  shall be  deemed to be
invalid by any court,  such  invalidity  shall not affect the  remainder of this
Agreement.



                                      -9-


          (d) Except as  otherwise  expressly  provided in this  Agreement,  any
notice, request, demand or other communication permitted or required to be given
under this Agreement shall be in writing,  shall be sent by one of the following
means to the parties at their  respective  addresses set forth below (or to such
other  address  as to which a party may from time to time give  notice to other)
and shall be deemed  conclusively to have been given:  (a) on the first business
day  following  the day timely  deposited  for next  business day delivery  with
Federal Express (or other similar national  overnight courier service) or United
States Express Mail, with the cost of delivery prepaid or for the account of the
sender;  (b) on the fifth  business day following the day duly sent by certified
or registered United States mail,  postage prepaid and return receipt requested;
or (c) when otherwise  actually  received by the addressee by hand delivery on a
business day (or on the next business day if received by hand delivery after the
close of normal business hours or on any non-business day)


          If to Debtor:           American Biogenetic Sciences, Inc.
                                  1375 Akron Street
                                  Copiague, New York 11726
                                  Attention: President

          If to Secured Party:    Mr. Alfred J. Roach
                                  207 Inlet Drive
                                  Lindenhurst, New York 11757

          (e) This  Agreement  shall be governed by and  construed in accordance
with the laws of the State of New York (without giving effect to its conflict of
laws rule that would  otherwise  require the  application of the laws of another
jurisdiction).

          (f) Any judicial  proceeding brought by or against Debtor with respect
to any of the  Obligations,  this  Agreement  or the Note may be  brought in any
court of  competent  jurisdiction  in the  State of New York,  United  States of
America,  and, by execution and delivery of this  Agreement,  Debtor accepts for
itself and in connection with its properties, generally and unconditionally, the
non-exclusive jurisdiction of the aforesaid courts, and irrevocably agrees to be
bound by any judgment rendered thereby in connection with the Obligations,  this
Agreement or the Note. Nothing herein shall affect the right to serve process in
any manner  permitted by law or shall limit the right of Secured  Party to bring
proceedings  against  Debtor in the  courts of any  other  jurisdiction.  Debtor
waives  any  objection  to  jurisdiction  and  venue  of any  action  instituted
hereunder  and shall not assert any  defense  based on lack of  jurisdiction  or
venue or based upon forum non  conveniens.  Any judicial  proceedings  by Debtor
against Secured Party involving,  directly or indirectly, any matter or claim in
any way arising  out of,  related to or  connected  with the  Obligations,  this
Agreement or the Note, shall be brought only in a federal or state court located
in the County of Suffolk, State of New York.



                                      -10-


          (g) THE  BORROWER  WAIVES ANY RIGHT TO JURY TRIAL IN  CONNECTION  WITH
THIS AGREEMENT OR THE NOTE, AND THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.

          (h) This  Agreement  shall be binding on Debtor and its successors and
assigns  and  shall  inure  to the  benefit  of  Secured  Party  and his  heirs,
executors,  estate,  successors  and assigns,  except that Debtor may not assign
this  Agreement  or the  Note,  or  assign or  delegate  any of its  obligations
hereunder or thereunder without the prior written consent of Secured Party.

          (i) All  references  to Debtor and Secured  Party herein shall include
their  respective  successors  and assigns.  All references to the term "person"
herein  shall mean an  individual,  sole  proprietorship,  limited  partnership,
general partnership,  a corporation  (including a business trust), a joint stock
company, a trust, an unincorporated  association,  a joint venture  association,
organization  or  other  entity  or  a  government  department  or  any  agency,
instrumentality or political subdivision thereof.

          (j) In the event of any conflict of any of the terms or  provisions of
this  Agreement  with any of the terms or provisions  of the Note,  the terms or
provisions of the Note shall control.

     IN WITNESS  WHEREOF,  Debtor and Secured Party have executed this Agreement
as of the day and year first above written.

                                   AMERICAN BIOGENETIC SCIENCES, INC.

                                   By: /s/ James H. McLinden
                                       -----------------------------------------
                                           James H. McLinden, President


                                       /s/ Alfred J. Roach
                                       -----------------------------------------
                                           Alfred J. Roach



                                      -11-



STATE OF NEW YORK     )
                      ) ss.:
COUNTY OF SUFFOLK     )


     As of this 17th day of September,  2002, before me personally came James H.
McLinden,  to me known,  who being duly  sworn,  did depose and say,  that he is
President of AMERICAN BIOGENETIC  SCIENCES,  INC., the corporation  described in
and which executed the foregoing instrument; and that he signed his name thereto
by order of the Board of Directors of said corporation.


                                       /s/ Leonard W. Suroff
                                       -----------------------------------------
                                       Notary Public




STATE OF NEW YORK     )
                      ) ss.:
COUNTY OF SUFFOLK     )


     As of this 17th day of September, 2002, before me personally came Alfred J.
Roach,  to me known,  who, being duly sworn,  did depose and say, that he is the
individual described in and who executed the foregoing  instrument;  and that he
signed his name thereto.

                                       /s/ Leonard W. Suroff
                                       -----------------------------------------
                                       Notary Public




                                      -12-




                                                              EXHIBIT A

                                                  LIST OF PATENTS AND APPLICATIONS


- ------------------------------------------------------------------------------------------------------------------------------------
DOCKET      PAT    RELATED    COUNTRY          SERIAL NO.       FILED     TITLE                           STATUS
            TYPE                                                                                          ISSUED
                                                                                                          EXPIRES/YR

                                                                                     
4697-034    CIP    4697-026   United States    07/364,053       6/8/89    Method For Production of        U.S. Patent No.
                                                                          Monoclonal Antibodies           5,120,834;
                                                                          Utilizing A Germfree Animal
                                                                                                          Issued
                                                                                                          6/9/92
                                                                                                          2009
4697-034-                     Canada           602,660          6/13/89                                   Patent No. 1,339,737
001                                                                                                       Issued 3/17/98
4697-034-                     United Kingdom   89906932.2       6/12/89                                   Patent No. GB0413763
002                                                                                                       Issued 6/12/89
4697-034-                     Germany          89906932.2       6/12/89                                   Patent No. P68927438.6-08
003                                                                                                       Issued 6/12/89
4697-034-                     France           89906932.2       6/12/89                                   Patent No. FR0413763
004                                                                                                       Issued 6/12/89
4697-034-                     Italy            89906932.2       6/12/89                                   Patent No. 29343/BE/96
005                                                                                                       Issued 6/12/89
4697-034-                     Japan            1-506610/89      6/12/89                                   Patent No. 2635192
012                                                                                                       Issued 6/12/89

- ------------------------------------------------------------------------------------------------------------------------------------



- ------------------------------------------------------------------------------------------------------------------------------------
DOCKET      PAT    RELATED    COUNTRY          SERIAL NO.       FILED     TITLE                           STATUS
            TYPE                                                                                          ISSUED
                                                                                                          EXPIRES/YR
4697-034-                     Rep. of Korea    700307/90        6/12/89                                   Patent No. 225183
187                                                                                                       Issued 6/12/89
4697-034-                     EPC              89906932.2       6/12/89                                   Patent No.  0413763
227                           W. Germany                                                                  Issued 6/12/89

4697-038    DIV    4697-034   United States    07/583,738       9/17/90   Fibrinogen-Specific Monoclonal  U.S. Patent No. 5,091,512
                                                                          Antibody                        2/25/92              2009
4697-054    CIP    4697-053   United States    08/086,423       7/2/93    Method for the Production of    U.S. Patent No. 5,453,359
                                                                          Monoclonal Antibodies Utilizing 9/26/95      2009
                                                                          a Germfree Animal
4697-054-                     Russian          96103363         6/22/94                                   Patent No.2173347
019                           Federation                                                                  Issued 6/22/94
4697-054-                     Korea (South)    705946/95        6/22/94                                   Pending
187                           United States
4697-065                                       08/204,015       2/24/94   Fibrin Specific Antibody for    U.S. Patent 5,487,892
                                                                          Use as an Antithrombotic Agent  Issued 1/30/96
4697-065-                     Canada           2/183/953        2/21/95                                   Exam Due 2/21/02
001
4697-065-                     Australia        18434/95         2/21/95                                   Patent No. 708897
007                                                                                                       Issued
4697-065-                     Mexico           9603602          2/21/95                                   Patent No.  204288
009                                                                                                       Convention Priority Date
                                                                                                          Feb 24, 1994
4697-065-                     Japan            7-7522375        2/21/95                                   Exam Due 2/21/02

- ------------------------------------------------------------------------------------------------------------------------------------


- ------------------------------------------------------------------------------------------------------------------------------------
DOCKET      PAT    RELATED    COUNTRY          SERIAL NO.       FILED     TITLE                           STATUS
            TYPE                                                                                          ISSUED
                                                                                                          EXPIRES/YR
012
4697-065-                     Russian          96119386         2/21/95                                   Patent No. 2152801
019                           Federation                                                                  Issued
4697-065-                     Brazil           PI9506949-6      2/21/95                                   Pending
037
4697-065-                     China            95192673.X       2/21/95                                   Pending
146
4697-071    CON    4697-041   United States    08/460,702       6/2/95    Methods for Therapeutic Uses    U.S. Patent 5,723,126
                                                                          of Fibrin-specific Monoclonal   3/3/98          2009
                                                                          Antibody
4697-073    CON    4697-041   United States    08/459,596       6/2/95    Immunoassay Ad Kit for in       U.S. Patent 5,843,690
                                                                          Vitro Detection of Soluble      12/1/98            2009
                                                                          DESAABB Fibrin Polymers
4697-092    CON    4697-034   United States    09/044,063       3/18/98   Methods for Treating a Fibrin   U.S. Patent 5,871,737
                                                                          Encapsulated Tumor Using a      2/16/99        2009
                                                                          Fibrin Specific Monoclonal
                                                                          Antibody and Compositions Used
                                                                          Therein
4697-096    CIP    4697-053   United States    09/207,913       12/9/98   Methods for Treating a Fibrin   U.S. Patent 6,187,593
                                                                          Encapsulated Tumor Using        2/13/01           2009
                                                                          a Fibrin Specific Monoclonal
                                                                          Antibody and Compositions
                                                                          Used Therein
- ------------------------------------------------------------------------------------------------------------------------------------






                                    EXHIBIT B

                            SPECIAL POWER OF ATTORNEY
                                    (PATENTS)

STATE OF NEW YORK      )
                       ) ss.:
COUNTY OF SUFFOLK      )

     KNOW ALL MEN BY THESE PRESENTS,  that AMERICAN  BIOGENETIC  SCIENCES,  INC.
("DEBTOR"),  having an office at 13785 Akron Street,  Copiague,  New York 11726,
hereby appoints and constitutes,  severally,  ALFRED J. ROACH ("SECURED PARTY"),
its true and  lawful  attorney,  with full power of  substitution  and with full
power and  authority  to perform the  following  acts on behalf of Debtor at any
time after the  occurrence  and during  the  continuance  of an Event of Default
under the Security Agreement (as hereinafter defined):

     1. Execution and delivery of any and all agreements,  documents, instrument
of assignment,  or other papers which Secured Party,  in its  discretion,  deems
necessary  or  advisable  for the purpose of  assigning,  selling,  or otherwise
disposing of all right,  title, and interest of Debtor in and to any patents and
all applications,  registrations, recordings, reissues, extensions, and renewals
thereof set forth on Exhibit A to the Security Agreement ( as defined below), or
for the purpose of recording,  registering and filing of, or  accomplishing  any
other formality with respect to the foregoing.

     2.   Execution  and  delivery  of  any  and  all   documents,   statements,
certificates  or other papers which  Secured  Party,  in its  discretion,  deems
necessary or advisable to further the purposes described in Section 1 hereof.

     This Power of Attorney,  being a power  coupled  with an interest,  is made
pursuant to a Patent Collateral Assignment and Security Agreement between Debtor
and Secured Party, of even date herewith (the "SECURITY  AGREEMENT") and may not
be revoked until payment in full of all Debtor's "Obligations",  as such term is
defined in the  Security  Agreement  and is subject to the terms and  provisions
thereof.

September __, 2002

                                     AMERICAN BIOGENETIC SCIENCES, INC.


                                        ----------------------------------------
                                            James H. McLinden
                                            President





STATE OF NEW YORK      )
                       ) ss.:
COUNTY OF SUFFOLK      )


     As of this ___ day of September,  2002,  before me personally came James H.
McLinden,  to me known,  who being duly sworn,  did depose and say, that he is a
President of AMERICAN BIOGENETIC  SCIENCES,  INC., the corporation  described in
and which executed the foregoing instrument; and that he signed his name thereto
by order of the Board of Directors of said corporation.



                                     -------------------------------------------
                                     Notary Public





                                    EXHIBIT C

                                    LICENSES


     1.   License   Agreement   dated  December  13,  1995  between  and  Abbott
          Laboratories, for American Biogenetic Sciences, Inc. TpP Product.

     2.   Development  and License  Agreement  dated  October  12, 1995  between
          American  Biogenetic  Sciences,  Inc. and F. Hoffman LaRoche Ltd., for
          American Biogenetic Sciences, Inc 's TpP Product.

     3.   Agreement dated December 1, 1983 between American Biogenetic Sciences,
          Inc.  and  University  of  Notre  Dame  wherein  American   Biogenetic
          Sciences, Inc. has agreed to pay Notre Dame a royalty of 5% of the net
          income  American  Biogenetic  Sciences,  Inc.  achieves  from sales of
          products resulting from American Biogenetic Sciences,  Inc . sponsored
          research activities at Notre Dame.

     4.   On January 24, 1992, the Company  entered into an exclusive,  15 years
          license   agreement   with   Yamanouchi   Pharmaceutical   Co.,   Ltd.
          ("Yamanouchi"),   a  Japanese   pharmaceutical   company.  Under  this
          agreement, Yamanouchi may manufacture, use or market diagnostic assays
          that contain American Biogenetic Sciences, Inc.'s monoclonal antibody,
          45-J, in Japan and Taiwan.