OPHTHALMIC IMAGING SYSTEMS


                          SECURITIES PURCHASE AGREEMENT


                              September 25th, 2003

















                                TABLE OF CONTENTS

                                                                            Page
                                                                            ----

1.       AGREEMENT TO SELL AND PURCHASE........................................1

2.       FEES AND WARRANTS.....................................................1

3.       CLOSING, DELIVERY AND PAYMENT.........................................2
         3.1      Closing......................................................2
         3.2      Delivery.....................................................2

4.       REPRESENTATIONS AND WARRANTIES OF THE COMPANY.........................2
         4.1      Organization, Good Standing and Qualification................3
         4.2      Subsidiaries.................................................3
         4.3      Capitalization; Voting Rights................................3
         4.4      Authorization; Binding Obligations...........................4
         4.5      Liabilities..................................................4
         4.6      Agreements; Action...........................................4
         4.7      Obligations to Related Parties...............................5
         4.8      Changes......................................................5
         4.9      Title to Properties and Assets; Liens, Etc...................6
         4.10     Intellectual Property........................................7
         4.11     Compliance with Other Instruments............................7
         4.12     Litigation...................................................7
         4.13     Tax Returns and Payments.....................................8
         4.14     Employees....................................................8
         4.15     Registration Rights and Voting Rights........................8
         4.16     Compliance with Laws; Permits................................9
         4.17     Environmental and Safety Laws................................9
         4.18     Valid Offering...............................................9
         4.19     Full Disclosure..............................................9
         4.20     Insurance...................................................10
         4.21     SEC Reports.................................................10
         4.22     Listing.....................................................10
         4.23     No Integrated Offering......................................10
         4.24     Stop Transfer...............................................10
         4.25     Dilution....................................................10


                                      -i-


5.       REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS.....................11

         5.1      Requisite Power and Authority...............................11
         5.2      Requisite Power and Authority...............................11
         5.3      Investment Representations..................................11
         5.4      Purchaser Bears Economic Risk...............................11
         5.5      Acquisition for Own Account.................................12
         5.6      Purchaser Can Protect Its Interest..........................12
         5.7      Accredited Investor.........................................12
         5.8      Legends.....................................................13

6.       COVENANTS OF THE COMPANY.............................................14
         6.1      Stop-Orders.................................................14
         6.2      Listing.....................................................14
         6.3      Market Regulations..........................................15
         6.4       Reporting Requirements.....................................15
         6.5      Use of Funds................................................15
         6.6      Access to Facilities........................................15
         6.7      Taxes.......................................................15
         6.8      Insurance...................................................15
         6.9      Intellectual Property.......................................16
         6.10     Properties..................................................16
         6.11     Confidentiality.............................................16
         6.12     Required Approvals..........................................16
         6.13     Reissuance of Securities....................................16
         6.14     Opinion.....................................................17

7.       COVENANTS OF THE COMPANY.............................................17
         7.1      Confidentiality.............................................17
         7.2      Non-Public Information......................................17
         7.3      Conditions Precedent........................................17

8.       COVENANTS OF THE COMPANY AND PURCHASERS REGARDING INDEMNIFICATION....18
         8.1      Company Indemnification.....................................18
         8.2      Purchaser's Indemnification.................................18
         8.3      Procedures..................................................18

                                      -ii-


9.       CONVERSION OF CONVERTIBLE NOTES......................................18
         9.1      Mechanics of Conversion.....................................18
         9.2      Maximum Conversion..........................................19

10.      REGISTRATION RIGHTS..................................................20
         10.1     Registration Rights Granted.................................20
         10.2     Offering Restrictions.......................................20
         10.3.    Right of First Refusal......................................20

11.      MISCELLANEOUS........................................................20
         11.1     Governing Law...............................................20
         11.2     Survival....................................................21
         11.3     Successors and Assigns......................................21
         11.4     Entire Agreement............................................21
         11.5     Severability................................................21
         11.6     Amendment and Waiver........................................21
         11.7     Delays or Omissions.........................................21
         11.8     Notices.....................................................22
         11.9     Attorneys' Fees.............................................22
         11.10    Titles and Subtitles........................................22
         11.11    Counterparts................................................22
         11.12    Broker's Fees...............................................22
         11.13    Construction................................................22








                                     -iii-



                          SECURITIES PURCHASE AGREEMENT


         THIS  SECURITIES  PURCHASE  AGREEMENT  (this  "Agreement")  is made and
entered into as of  September  25th,  2003,  by and between  Ophthalmic  Imaging
Systems, a California corporation (the "Company"), and Laurus Master Fund, Ltd.,
a Cayman Islands company (the "Purchaser").

                                    RECITALS

         WHEREAS,  the Company has  authorized  the sale to the  Purchaser  of a
Convertible  Term Note in the  aggregate  principal  amount of  $1,200,000  (the
"Note"), which Note is convertible into shares of the Company's common stock, no
par value per share (the "Common  Stock") at a fixed  conversion  price of $1.07
per share of Common Stock ("Fixed Conversion Price");

         WHEREAS,  the  Company  wishes to issue a warrant to the  Purchaser  to
purchase up to 375,000 shares of the Company's  Common Stock in connection  with
Purchaser's purchase of the Note;

         WHEREAS,  Purchaser  desires to  purchase  the Note and  Warrant on the
terms and conditions set forth herein; and

         WHEREAS,  the Company desires to issue and sell the Note and Warrant to
Purchaser on the terms and conditions set forth herein.

                                    AGREEMENT

         NOW,  THEREFORE,  in  consideration  of the foregoing  recitals and the
mutual promises, representations, warranties and covenants hereinafter set forth
and for other good and valuable  consideration,  the receipt and  sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

         1. AGREEMENT TO SELL AND PURCHASE. Pursuant to the terms and conditions
set forth in this Agreement,  on the Closing Date (as defined in Section 3), the
Company  agrees to sell to the  Purchaser,  and the  Purchaser  hereby agrees to
purchase  from the  Company a Note in the amount of  $1,200,000  convertible  in
accordance  with the terms thereof into shares of the Company's  Common Stock in
accordance with the terms of the Note and this Agreement.  The Note purchased on
the Closing Date shall be known as the "Offering." A form of the Note is annexed
hereto as Exhibit A. The Note will have a Maturity Date (as defined in the Note)
thirty six (36) months  from the date of  issuance.  Collectively,  the Note and
Warrant  (as defined in Section 2) and Common  Stock  issuable in payment of the
Note,  upon conversion of the Note and upon exercise of the Warrant are referred
to as the "Securities".

         2.  FEES AND WARRANT. On the Closing Date:

                  (a) The  Company  will issue and  deliver to the  Purchaser  a
Warrant  to  purchase  375,000  shares of Common  Stock in  connection  with the
Offering  (the  "Warrant")  pursuant to Section 1 hereof.  The  Warrant  must be
delivered on the Closing Date. A form of


                                       1


Warrant is annexed  hereto as  Exhibit  B. All the  representations,  covenants,
warranties,  undertakings, and indemnification, and other rights made or granted
to or for the benefit of the  Purchaser  by the Company are hereby also made and
granted in respect of the  Warrant  and  shares of the  Company's  Common  Stock
issuable upon exercise of the Warrant (the "Warrant Shares").

                  (b) Upon  execution  and  delivery  of this  Agreement  by the
Company and Purchaser , the Company shall pay to Laurus Capital Management, LLC,
manager of Purchaser  (i) a closing  payment in an amount equal to three and one
half percent (3.5%) of the aggregate principal amount of the Note. The foregoing
fee is referred to herein as the "Closing Payment".

                  (c)  The  Company  shall   reimburse  the  Purchaser  for  its
reasonable  legal fees for services  rendered to the Purchaser in preparation of
this Agreement and the Related Agreements (as hereinafter defined), and expenses
in  connection  with the  Purchaser's  due  diligence  review of the Company and
relevant  matters.  Amounts  required to be paid  hereunder  will be paid at the
Closing and shall not exceed  $22,000 for legal fees and expenses and performing
due diligence inquiries on the Company.

                  (d) The Closing  Payment,  legal fees and due  diligence  fees
(net of deposits  previously paid by the Company shall be paid at closing out of
funds held pursuant to a Funds Escrow  Agreement of even date herewith among the
company,  Purchaser,  and an Escrow Agent (the "Funds Escrow  Agreement")  and a
disbursement letter (the "Disbursement Letter").

         3.  CLOSING, DELIVERY AND PAYMENT.

             3.1  Closing.  Subject  to the terms  and  conditions  herein,  the
closing of the  transactions  contemplated  hereby (the  "Closing"),  shall take
place on the date hereof, at such time or place as the Company and Purchaser may
mutually agree (such date is hereinafter referred to as the "Closing Date").

             3.2  Delivery.  Pursuant to the Funds Escrow  Agreement in the form
attached  hereto as Exhibit C, at the Closing on the Closing  Date,  the Company
will deliver to the Purchaser,  among other things,  a Note in the form attached
as Exhibit A  representing  the principal  amount of $1,200,000 and a Warrant in
the form  attached as Exhibit B in the  Purchaser's  name  representing  375,000
Warrant  Shares and the  Purchaser  will  deliver to the  Company,  among  other
things,  the amounts set forth in the Disbursement  Letter by certified funds or
wire transfer.

         4. REPRESENTATIONS AND WARRANTIES OF THE COMPANY.

                  The Company hereby represents and warrants to the Purchaser as
of the date of this Agreement as set forth below which disclosures are
supplemented by, and subject to the Company's filings under the Securities
Exchange Act of 1934 (collectively, the "Exchange Act Filings"), copies of which
have been provided or made available to the Purchaser.

             4.1 Organization, Good Standing and Qualification. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of


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California. The Company has the corporate power and authority to own and operate
its properties and assets,  to execute and deliver this Agreement,  and the Note
and the Warrant to be issued in  connection  with this  Agreement,  the Security
Agreement  relating to the Note dated as of  September  25th,  2003  between the
Company and the Purchaser,  the Registration  Rights  Agreement  relating to the
Securities  dated  as of  September  25th,  2003  between  the  Company  and the
Purchaser  and all  other  agreements  referred  to  herein  (collectively,  the
"Related Agreements"), to issue and sell the Note and the shares of Common Stock
issuable upon conversion of the Note (the "Note Shares"),  to issue and sell the
Warrant  and  the  Warrant  Shares,  and to  carry  out the  provisions  of this
Agreement and the Related  Agreements  and to carry on its business as presently
conducted. The Company is duly qualified and is authorized to do business and is
in good  standing as a foreign  corporation  in all  jurisdictions  in which the
nature of its  activities  and of its  properties  (both owned and leased) makes
such qualification necessary, except for those jurisdictions in which failure to
do so would not have a material adverse effect on the Company or its business.

             4.2 Subsidiaries. The Company has no subsidiaries. The Company does
not  own or  control  any  equity  security  or  other  interest  of  any  other
corporation, limited partnership or other business entity.

             4.3 Capitalization; Voting Rights.

                  (a) The  authorized  capital  stock of the Company,  as of the
date  hereof  consists of  40,000,000shares,  of which  20,000,000are  shares of
Common Stock, no par value per share,  14,354,521shares  of which are issued and
outstanding, and no shares of preferred stock are issued and outstanding.

                  (b) Except as  disclosed  on Schedule  4.3 or disclosed in any
Exchange Act Filings,  other than (i) the shares reserved for issuance under the
Company's stock option plans;  and (ii) shares which may be granted  pursuant to
this Agreement and the Related  Agreements,  there are no  outstanding  options,
warrants,  rights (including conversion or preemptive rights and rights of first
refusal), proxy or stockholder agreements,  or arrangements or agreements of any
kind for the purchase or acquisition  from the Company of any of its securities.
Except as disclosed on Schedule 4.3 or as disclosed in any Exchange Act Filings,
neither  the  offer,  issuance  or sale of any of the  Note or  Warrant,  or the
issuance of any of the Note Shares or Warrant  Shares,  nor the  consummation of
any  transaction  contemplated  hereby  will  result in a change in the price or
number of any  securities of the Company  outstanding,  under  anti-dilution  or
other similar provisions contained in or affecting any such securities.

                  (c) All issued and outstanding  shares of the Company's Common
Stock (i) have been duly  authorized  and validly  issued and are fully paid and
nonassessable  and (ii) were issued in compliance with all applicable  state and
federal laws concerning the issuance of securities.

                  (d) The rights,  preferences,  privileges and  restrictions of
the  shares of the  Common  Stock are as stated  in the  Company's  Articles  of
Incorporation (the "Charter"). The Note Shares and Warrant Shares have been duly
and validly reserved for issuance. When issued in compliance with the provisions
of this  Agreement and the Company's  Charter,  the  Securities


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will be validly issued,  fully paid and  nonassessable,  and will be free of any
liens or encumbrances;  provided, however, that the Securities may be subject to
restrictions on transfer under state and/or federal securities laws as set forth
herein or as otherwise required by such laws at the time a transfer is proposed.

             4.4 Authorization; Binding Obligations. All corporate action on the
part of the Company,  its officers and directors necessary for the authorization
of this Agreement and the Related Agreements, the performance of all obligations
of the Company hereunder at the Closing and, the authorization,  sale,  issuance
and  delivery  of the Note and  Warrant has been taken or will be taken prior to
the  Closing.  The  Agreement  and the Related  Agreements,  when  executed  and
delivered  and to the extent it is a party  thereto,  will be valid and  binding
obligations of the Company  enforceable in accordance  with their terms,  except
(a) as limited by applicable bankruptcy, insolvency, reorganization,  moratorium
or other laws of general application affecting enforcement of creditors' rights,
and (b) general principles of equity that restrict the availability of equitable
or legal  remedies.  The sale of the Note and the  subsequent  conversion of the
Note into Note Shares are not and will not be subject to any  preemptive  rights
or rights of first refusal that have not been properly  waived or complied with.
The  issuance  of the  Warrant  and the  subsequent  exercise of the Warrant for
Warrant  Shares  are not and will not be  subject  to any  preemptive  rights or
rights of first refusal that have not been properly waived or complied with.

             4.5  Liabilities.  As of June 30, 2003 the Company,  to the best of
its  knowledge,   has  no  material  contingent   liabilities,   except  current
liabilities  incurred  in  the  ordinary  course  of  business  and  liabilities
disclosed in any Exchange Act Filings.

             4.6 Agreements;  Action.  Except as set forth on Schedule 4.6 or as
disclosed in any Exchange Act Filings:

                  (a)  There  are no  agreements,  understandings,  instruments,
contracts,  proposed transactions,  judgments, orders, writs or decrees to which
the  Company  is a party or to its  knowledge  by which  it is bound  which  may
involve (i)  obligations  (contingent  or  otherwise)  of, or  payments  to, the
Company in excess of $50,000  (other than  obligations  of, or payments  to, the
Company  arising from purchase or sale  agreements  entered into in the ordinary
course of business),  or (ii) the transfer or license of any patent,  copyright,
trade  secret or other  proprietary  right to or from the  Company  (other  than
licenses  arising  from the  purchase  of "off  the  shelf"  or  other  standard
products),  or (iii)  provisions  restricting  the  development,  manufacture or
distribution of the Company's products or services,  or (iv)  indemnification by
the Company with respect to infringements of proprietary rights.

                  (b) Since June 30,  2003,  the Company has not (i) declared or
paid any dividends,  or authorized or made any distribution upon or with respect
to any class or series of its capital stock,  (ii) incurred any indebtedness for
money borrowed or any other liabilities (other than ordinary course obligations)
individually  in  excess  of  $50,000  or,  in the case of  indebtedness  and/or
liabilities  individually  less  than  $50,000,  in excess  of  $100,000  in the
aggregate,  (iii)  made any  loans or  advances  to any  person  not in  excess,
individually or in the aggregate, of $100,000,  other than ordinary advances for
travel  expenses,  or (iv) sold,  exchanged



                                       4


or otherwise disposed of any of its assets or rights, other than the sale of its
inventory in the ordinary course of business.

                  (c) For the  purposes of  subsections  (a) and (b) above,  all
indebtedness,  liabilities, agreements,  understandings,  instruments, contracts
and proposed transactions involving the same person or entity (including persons
or entities the Company has reason to believe are affiliated therewith) shall be
aggregated for the purpose of meeting the  individual  minimum dollar amounts of
such subsections.

             4.7 Obligations to Related Parties. Except as set forth on Schedule
4.7 or as disclosed in any Exchange Act Filings, there are no obligations of the
Company to officers,  directors,  stockholders or employees of the Company other
than (a) for payment of salary for services rendered and for bonus payments, (b)
reimbursement for reasonable expenses incurred on behalf of the Company, (c) for
other  standard  employee  benefits  made  generally  available to all employees
(including  stock  option  agreements  outstanding  under any stock  option plan
approved by the Board of Directors of the Company) and (d) obligations listed in
the  Company's  financial  statements  or  disclosed  in any of its Exchange Act
Filings.  Except as described above or set forth on Schedule 4.7 or as disclosed
in any Exchange Act Filings, none of the officers,  directors or, to the best of
the Company's  knowledge,  key employees or  stockholders  of the Company or any
members of their immediate families,  are indebted to the Company,  individually
or in the  aggregate,  in  excess of  $50,000  or have any  direct  or  indirect
ownership  interest  in any  firm or  corporation  with  which  the  Company  is
affiliated or with which the Company has a business relationship, or any firm or
corporation which competes with the Company,  other than passive  investments in
publicly traded companies  (representing less than 1% of such company) which may
compete with the Company.  Except as described  above,  no officer,  director or
stockholder,  or any  member  of  their  immediate  families,  is,  directly  or
indirectly,  interested  in  any  material  contract  with  the  Company  and no
agreements, understandings or proposed transactions are contemplated between the
Company and any such person. Except as set forth on Schedule 4.7, the Company is
not a guarantor or indemnitor of any  indebtedness of any other person,  firm or
corporation.

             4.8  Changes.  Since  June 30,  2003,  except as  disclosed  in any
Exchange  Act  Filing  or in any  Schedule  to this  Agreement  or to any of the
Related Agreements, there has not been:

                  (a)  Any  change  in  the   assets,   liabilities,   financial
condition,  prospects or  operations  of the Company,  other than changes in the
ordinary course of business,  none of which individually or in the aggregate has
had or is reasonably  expected to have a material adverse effect on such assets,
liabilities, financial condition, prospects or operations of the Company;

                  (b)  Any  resignation  or  termination  of  any  officer,  key
employee or group of employees of the Company;

                  (c) Any  material  change,  except in the  ordinary  course of
business,  in the  contingent  obligations  of the  Company by way of  guaranty,
endorsement, indemnity, warranty or otherwise;



                                       5


                  (d) Any damage, destruction or loss, whether or not covered by
insurance,  materially  and  adversely  affecting  the  properties,  business or
prospects or financial condition of the Company;

                  (e) Any  waiver by the  Company  of a  valuable  right or of a
material debt owed to it;

                  (f) Any direct or indirect  material loans made by the Company
to any  stockholder,  employee,  officer or director of the Company,  other than
advances made in the ordinary course of business;

                  (g) Any material  change in any  compensation  arrangement  or
agreement with any employee, officer, director or stockholder;

                  (h) Any  declaration  or  payment  of any  dividend  or  other
distribution of the assets of the Company;

                  (i) Any labor organization activity related to the Company;

                  (j) Any debt,  obligation  or liability  incurred,  assumed or
guaranteed by the Company,  except those for immaterial  amounts and for current
liabilities incurred in the ordinary course of business;

                  (k)  Any  sale,   assignment   or  transfer  of  any  patents,
trademarks, copyrights, trade secrets or other intangible assets;

                  (l) Any change in any material  agreement to which the Company
is a party or by which it is bound which may materially and adversely affect the
business, assets, liabilities,  financial condition,  operations or prospects of
the Company;

                  (m) Any other event or condition of any character that, either
individually  or  cumulatively,  has or may materially and adversely  affect the
business, assets, liabilities,  financial condition,  prospects or operations of
the Company; or

                  (n) Any  arrangement or commitment by the Company to do any of
the acts described in subsection (a) through (m) above.

             4.9 Title to Properties and Assets;  Liens,  Etc. (a) Except as set
forth on  Schedule  4.9(a)  which  shall set forth  liens  levied on the Company
existing on the date hereof ("Permitted  Liens") or as disclosed in any Exchange
Act Filings  filed as of the date  hereof,  the Company has good and  marketable
title to its properties and assets, and good title to its leasehold estates,  in
each case subject to no mortgage,  pledge,  lien, lease,  encumbrance or charge,
other than (a) those resulting from taxes which have not yet become  delinquent,
(b) minor liens and encumbrances  which do not materially detract from the value
of the property  subject  thereto or  materially  impair the  operations  of the
Company,  and (c) those that have  otherwise  arisen in the  ordinary  course of
business. All facilities,  machinery,  equipment,  fixtures,  vehicles and other
properties owned,  leased or used by the Company are in good operating condition
and repair and are reasonably fit and usable for the purposes for which they are
being  used.  Except as set forth



                                       6


on Schedule  4.9(b) or as disclosed in any Exchange Act Filings  filed as of the
date hereof,  the Company is in compliance with all material terms of each lease
to which it is a party or is otherwise bound.

             4.10 Intellectual Property.

                  (a) The Company owns or possesses  sufficient  legal rights to
all patents, trademarks,  service marks, trade names, copyrights, trade secrets,
licenses,  information and other proprietary rights and processes  necessary for
its  business as now  conducted  and to the  Company's  knowledge  as  presently
proposed  to be  conducted  (the  "Intellectual  Property"),  without  any known
infringement of the rights of others. There are no outstanding options, licenses
or agreements of any kind relating to the foregoing  proprietary  rights, nor is
the Company  bound by or a party to any options,  licenses or  agreements of any
kind with  respect to the  patents,  trademarks,  service  marks,  trade  names,
copyrights,  trade secrets,  licenses,  information and other proprietary rights
and  processes  of any other  person  or entity  other  than  such  licenses  or
agreements arising from the purchase of "off the shelf" or standard products.

                  (b) The Company has not received any  communications  alleging
that the Company has  violated any of the patents,  trademarks,  service  marks,
trade names,  copyrights  or trade  secrets or other  proprietary  rights of any
other person or entity, nor is the Company aware of any basis therefor.

                  (c) The Company does not believe it is or will be necessary to
utilize any inventions,  trade secrets or proprietary  information of any of its
employees made prior to their employment by the Company,  except for inventions,
trade secrets or proprietary  information that have been rightfully  assigned to
the Company.

             4.11  Compliance  with  Other  Instruments.  Except as set forth on
Schedule 4.11 or as disclosed in any Exchange Act Filings, the Company is not in
violation  or default of any term of its Charter or Bylaws,  or of any  material
provision  of  any  mortgage,  indenture,  contract,  agreement,  instrument  or
contract  to which  it is  party  or by  which  it is bound or of any  judgment,
decree, order or writ. The execution, delivery and performance of and compliance
with this Agreement and the Related  Agreements to which it is a party,  and the
issuance  and sale of the Note by the  Company and the other  Securities  by the
Company each pursuant  hereto,  will not, with or without the passage of time or
giving of notice, result in any such material violation,  or be in conflict with
or  constitute  a default  under any such  term or  provision,  or result in the
creation of any mortgage,  pledge,  lien,  encumbrance or charge upon any of the
properties or assets of the Company or the suspension,  revocation,  impairment,
forfeiture  or  nonrenewal  of any permit,  license,  authorization  or approval
applicable  to the Company,  its business or  operations or any of its assets or
properties.

             4.12  Litigation.  Except  as set  forth  on  Schedule  4.12  or as
disclosed in any Exchange Act Filings,  there is no action, suit,  proceeding or
investigation  pending  or, to the  Company's  knowledge,  currently  threatened
against the Company that  prevents  the Company to enter into this  Agreement or
the Related Agreements, or to consummate the transactions contemplated hereby or
thereby, or which might result, either individually or in the aggregate,  in any
material  adverse change in the assets,  condition,  affairs or prospects of the
Company,



                                       7


financially or otherwise,  or any change in the current equity  ownership of the
Company,  nor is the  Company  aware  that  there  is any  basis  for any of the
foregoing. The Company is not a party or subject to the provisions of any order,
writ,  injunction,  judgment  or  decree of any  court or  government  agency or
instrumentality.  There is no action,  suit,  proceeding or investigation by the
Company currently pending or which the Company intends to initiate.

             4.13 Tax Returns and Payments. The Company has timely filed all tax
returns  (federal,  state and local) required to be filed by it. All taxes shown
to be due and  payable on such  returns,  any  assessments  imposed,  and to the
Company's  knowledge all other taxes due and payable by the Company on or before
the  Closing,  have  been  paid or will be paid  prior to the time  they  become
delinquent. Except as set forth on Schedule 4.13 or as disclosed in any Exchange
Act  Filings,  the  Company has not been  advised  (a) that any of its  returns,
federal,  state or other,  have been or are being audited as of the date hereof,
or (b) of any  deficiency  in  assessment  or proposed  judgment to its federal,
state or other taxes.  The Company has no knowledge of any  liability of any tax
to be imposed  upon its  properties  or assets as of the date of this  Agreement
that is not adequately provided for.

             4.14  Employees.  Except as set forth on Schedule 4.14, the Company
has no collective bargaining  agreements with any of its employees.  There is no
labor  union  organizing  activity  pending  or,  to  the  Company's  knowledge,
threatened with respect to the Company.  Except as disclosed in the Exchange Act
Filings  or on  Schedule  4.14,  the  Company  is not a party to or bound by any
currently effective  employment  contract,  deferred  compensation  arrangement,
bonus plan,  incentive plan, profit sharing plan,  retirement agreement or other
employee compensation plan or agreement. To the Company's knowledge, no employee
of the Company,  nor any consultant with whom the Company has contracted,  is in
violation  of any  term  of any  employment  contract,  proprietary  information
agreement or any other agreement relating to the right of any such individual to
be employed by, or to contract  with,  the Company  because of the nature of the
business to be conducted  by the Company;  and to the  Company's  knowledge  the
continued  employment  by  the  Company  of  its  present  employees,   and  the
performance of the Company's  contracts with its independent  contractors,  will
not  result in any such  violation.  The  Company  is not aware  that any of its
employees is  obligated  under any contract  (including  licenses,  covenants or
commitments  of any  nature) or other  agreement,  or  subject to any  judgment,
decree or order of any court or administrative agency, that would interfere with
their  duties to the Company.  The Company has not received any notice  alleging
that any such  violation has  occurred.  Except for employees who have a current
effective  employment agreement with the Company, no employee of the Company has
been granted the right to continued employment by the Company or to any material
compensation following termination of employment with the Company. Except as set
forth on Schedule 4.14, the Company is not aware that any officer,  key employee
or group of employees intends to terminate his, her or their employment with the
Company,  nor does  the  Company  have a  present  intention  to  terminate  the
employment of any officer, key employee or group of employees.

             4.15 Registration Rights and Voting Rights.  Except as set forth on
Schedule  4.15 and except as disclosed  in Exchange Act Filings,  the Company is
presently not under any obligation,  and has not granted any rights, to register
any of the Company's presently  outstanding  securities or any of its securities
that may hereafter be issued.  Except as set forth on Schedule 4.15and except as
disclosed in Exchange Act Filings, to the Company's knowledge, no



                                       8


stockholder  of the Company has entered into any  agreement  with respect to the
voting of equity securities of the Company.

             4.16 Compliance with Laws; Permits. Except as set forth on Schedule
4.16 or as disclosed in any Exchange Act Filings, to its knowledge,  the Company
is not in violation in any material  respect of any  applicable  statute,  rule,
regulation,  order or restriction  of any domestic or foreign  government or any
instrumentality  or agency  thereof in respect of the conduct of its business or
the ownership of its properties  which violation would  materially and adversely
affect the business,  assets,  liabilities,  financial condition,  operations or
prospects  of  the  Company.  No  governmental  orders,  permissions,  consents,
approvals or authorizations  are required to be obtained and no registrations or
declarations  are  required to be filed in  connection  with the  execution  and
delivery of this  Agreement  and the issuance of any of the  Securities,  except
such as has been duly and  validly  obtained  or filed,  or with  respect to any
filings  that  must be made  after  the  Closing,  as will be  filed in a timely
manner.  The Company has all  material  franchises,  permits,  licenses  and any
similar  authority  necessary  for the  conduct  of its  business  as now  being
conducted by it, the lack of which would  materially  and  adversely  affect the
business, properties, prospects or financial condition of the Company.

             4.17 Environmental and Safety Laws. The Company is not in violation
of any  applicable  statute,  law or regulation  relating to the  environment or
occupational health and safety, and to its knowledge,  no material  expenditures
are or will be required in order to comply with any such existing  statute,  law
or regulation.  Except as set forth on Schedule 4.17, no Hazardous Materials (as
defined below) are used or have been used, stored, or disposed of by the Company
or, to the  Company's  knowledge,  by any other person or entity on any property
owned,  leased  or  used  by the  Company.  For the  purposes  of the  preceding
sentence,  "Hazardous  Materials"  shall mean (a) materials  which are listed or
otherwise defined as "hazardous" or "toxic" under any applicable  local,  state,
federal and/or  foreign laws and  regulations  that govern the existence  and/or
remedy of  contamination  on property,  the protection of the  environment  from
contamination,  the control of hazardous wastes,  or other activities  involving
hazardous  substances,  including  building  materials,  or  (b)  any  petroleum
products or nuclear materials.

             4.18 Valid Offering.  Assuming the accuracy of the  representations
and warranties of the Purchaser contained in this Agreement, the offer, sale and
issuance of the Securities will be exempt from the registration  requirements of
the Securities  Act of 1933, as amended (the  "Securities  Act"),  and will have
been registered or qualified (or are exempt from registration and qualification)
under the registration,  permit or qualification  requirements of all applicable
state securities laws.

             4.19 Full  Disclosure.  The Company has provided the Purchaser with
all  information  requested by the Purchaser in connection  with its decision to
purchase the Note and Warrant, including all information the Company believes is
reasonably necessary to make such investment  decision.  Neither this Agreement,
the exhibits and schedules hereto, the Related Agreements nor any other document
delivered by the Company to Purchaser or its  attorneys or agents in  connection
herewith or therewith or with the transactions  contemplated  hereby or thereby,
contain  any untrue  statement  of a material  fact nor omit to state a material
fact necessary in order to make the statements  contained herein or therein,  in
light of the circumstances in which they are made, not misleading. Any financial
projections  and other  estimates  provided to



                                       9


the  Purchaser  by the Company  were based on the  Company's  experience  in the
industry and on  assumptions  of fact and opinion as to future  events which the
Company, at the date of the issuance of such projections or estimates,  believed
to be reasonable.

             4.20  Insurance.  The  Company  has  general  commercial,   product
liability, fire and casualty insurance policies with coverages which the Company
believes are customary for  companies  similarly  situated to the Company in the
same or similar business.

             4.21 SEC Reports. Except as set forth on Schedule 4.21, the Company
has filed all proxy statements, reports and other documents required to be filed
by it under the Exchange  Act. The Company has  furnished or made  available the
Purchaser  with  copies of (i) its Annual  Report on Form  10-KSB for the fiscal
year ended  December 31, 2002 and (ii) its Quarterly  Reports on Form 10-QSB for
the fiscal quarters ended March 31, 2003 and June 30, 2003, (iii) its Definitive
Proxy  Statement  filed on November 11, 2002 and (iv) the Form 8-K filings which
it made during 2003 to date  (collectively,  the "SEC  Reports").  Except as set
forth on Schedule  4.21,  each SEC Report  was,  at the time of its  filing,  in
substantial  compliance with the requirements of its respective form and none of
the SEC Reports,  nor the financial  statements (and the notes thereto) included
in the SEC Reports,  as of their respective  filing dates,  contained any untrue
statement of a material  fact or omitted to state a material fact required to be
stated  therein or necessary  to make the  statements  therein,  in light of the
circumstances under which they were made, not misleading.

             4.22 Listing.  The Company's  Common Stock is listed for trading on
the NASD Over the Counter  Bulletin Board and satisfies all requirements for the
continuation  of such listing.  The Company has not received any notice that its
Common Stock will be delisted from the NASD Over the Counter  Bulletin  Board or
that its Common Stock does not meet all requirements for listing.

             4.23 No Integrated  Offering.  Neither the Company,  nor any of its
affiliates,  nor any  person  acting on its or their  behalf,  has  directly  or
indirectly  made any offers or sales of any security or solicited  any offers to
buy any  security  under  circumstances  that would  cause the  offering  of the
Securities  pursuant to this Agreement to be integrated  with prior offerings by
the Company for purposes of the  Securities  Act which would prevent the Company
from selling the Securities  pursuant to Rule 506 under the  Securities  Act, or
any applicable  exchange-related  stockholder approval provisions,  nor will the
Company or any of its affiliates or  subsidiaries  take any action or steps that
would cause the offering of the Securities to be integrated with other offerings
(other than such concurrent offering to the Purchaser).

             4.24 Stop Transfer.  The Securities are restricted securities as of
the date of this  Agreement.  The Company will not issue any stop transfer order
or other order  impeding the sale and delivery of any of the  Securities at such
time as the  Securities  are  registered  for public sale or an  exemption  from
registration  is available,  except as required by state and federal  securities
laws.

             4.25  Dilution.  The  Company  specifically  acknowledges  that its
obligation  to issue the shares of Common Stock upon  conversion of the Note and
exercise of the Warrant is



                                       10


binding  upon the  Company  and  enforceable  regardless  of the  dilution  such
issuance  may  have on the  ownership  interests  of other  shareholders  of the
Company.

         5. REPRESENTATIONS AND WARRANTIES OF THE PURCHASER.

The Purchaser hereby represents and warrants to the Company as follows (such
representations and warranties do not lessen or obviate the representations and
warranties of the Company set forth in this Agreement):

             5.1 No  Shorting.  The  Purchaser  or any  of  its  affiliates  and
investment  partners will not and will not cause any person or entity,  directly
or indirectly,  to engage in "short sales" of the Company's  Common Stock or any
other hedging strategies for as long as the Note is outstanding.

             5.2  Requisite  Power and  Authority.  Purchaser  has all necessary
power and  authority  under all  applicable  provisions  of law to  execute  and
deliver  this  Agreement  and the  Related  Agreements  and to carry  out  their
provisions.  All corporate  action on  Purchaser's  part required for the lawful
execution and delivery of this Agreement and the Related Agreements have been or
will be  effectively  taken  prior to the  Closing.  Upon  their  execution  and
delivery,  this Agreement and the Related  Agreements  will be valid and binding
obligations of Purchaser, enforceable in accordance with their terms, except (a)
as limited by applicable bankruptcy, insolvency,  reorganization,  moratorium or
other laws of general  application  affecting  enforcement of creditors' rights,
and  (b)  as  limited  by  general   principles  of  equity  that  restrict  the
availability of equitable and legal remedies.

             5.3  Investment  Representations.  Purchaser  understands  that the
Securities are being offered and sold pursuant to an exemption from registration
contained in the Securities Act based in part upon  Purchaser's  representations
contained in the Agreement, including, without limitation, that the Purchaser is
an "accredited investor" within the meaning of Regulation D under the Securities
Act of 1933, as amended (the "Securities  Act"). The Purchaser  confirms that it
has  received  or has had  full  access  to all  the  information  it  considers
necessary or appropriate to make an informed investment decision with respect to
the Note and the Warrant to be purchased by it under this Agreement and the Note
Shares and the Warrant Shares acquired by it upon the conversion of the Note and
the exercise of the Warrant,  respectively.  The Purchaser further confirms that
it has had an opportunity to ask questions and receive  answers from the Company
regarding the Company's business, management and financial affairs and the terms
and conditions of the Offering,  the Note, the Warrant and the Securities and to
obtain  additional  information  (to  the  extent  the  Company  possessed  such
information  or  could  acquire  it  without  unreasonable  effort  or  expense)
necessary to verify any  information  furnished to the Purchaser or to which the
Purchaser had access.

             5.4  Purchaser  Bears  Economic  Risk.  Purchaser  has  substantial
experience in  evaluating  and investing in private  placement  transactions  of
securities  in  companies  similar  to the  Company  so  that it is  capable  of
evaluating  the merits and risks of its  investment  in the  Company and has the
capacity to protect its own interests.  Purchaser must bear the economic risk of
this  investment  until the  Securities  are sold  pursuant to (i) an  effective
registration



                                       11


statement  under the Securities  Act, or (ii) an exemption from  registration is
available with respect to such sale.

             5.5  Acquisition  for Own Account.  Purchaser is acquiring the Note
and  Warrant  and the Note Shares and the  Warrant  Shares for  Purchaser's  own
account for  investment  only, and not as a nominee or agent and not with a view
towards or for resale in connection with their  distribution.  Purchaser has not
offered nor sold any portion of the Securities being acquired nor does Purchaser
have any  intention  of  dividing  the  Securities  with  others or of  selling,
distributing or otherwise disposing of any of the Securities either currently or
after  the  passage  of a fixed  or  determinable  period  of  time or upon  the
occurrence  or  non-occurrence  of  any  predetermined  event  or  circumstance;
provided, however, that by making the representations herein, Purchaser does not
agree to hold any of the  Securities  for any minimum or other specific term and
reserves the right to dispose of the  Securities at any time in accordance  with
or pursuant to a registration statement or an exemption under the Securities Act
and in compliance with this Agreement.

             5.6 Purchaser Can Protect Its Interest.  Purchaser  represents that
by reason of its, or of its  management's,  business and  financial  experience,
Purchaser has the capacity to evaluate the merits and risks of its investment in
the Note,  the Warrant and the  Securities  and to protect its own  interests in
connection with the transactions contemplated in this Agreement, and the Related
Agreements.  Further,  Purchaser is aware of no publication of any advertisement
in connection with the transactions contemplated in the Agreement or the Related
Agreements.

             5.7  Accredited  Investor.  Purchaser  represents  that  it  is  an
accredited  investor within the meaning of Regulation D under the Securities Act
and that the Purchaser is not a broker-dealer.

             5.8  Patriot  Act.  If  the  Purchaser  is  a  corporation,  trust,
partnership,  limited  liability  company or other  organization,  the Purchaser
certifies that, to the best of Purchaser's knowledge, the Purchaser has not been
designated,  and is not  owned or  controlled,  by a  "suspected  terrorist"  as
defined in Executive Order 13224.  The Purchaser  hereby  acknowledges  that the
Company seeks to comply with all applicable laws concerning money laundering and
related  activities.  In  furtherance  of those  efforts,  the Purchaser  hereby
represents,  warrants and agrees that: (i) none of the cash or property that the
Purchaser  will  pay or will  contribute  to the  Company  has  been or shall be
derived from, or related to, any activity that is deemed  criminal  under United
States law; and (ii) no contribution or payment by the Purchaser to the Company,
to the extent  that they are  within the  Purchaser's  control  shall  cause the
Company to be in  violation  of the United  States Bank  Secrecy Act, the United
States  International  Money Laundering Control Act of 1986 or the United States
International  Money Laundering  Abatement and  Anti-Terrorist  Financing Act of
2001.  The  Purchaser  shall  promptly  notify  the  Company  if  any  of  these
representations  ceases to be true and accurate  regarding  the  Purchaser.  The
Purchaser agrees to provide the Company any additional information regarding the
Purchaser  that the Company deems  necessary or convenient to ensure  compliance
with all applicable laws concerning money laundering and similar activities. The
Purchaser  understands  and agrees that if at any time it is discovered that any
of the foregoing  representations  are  incorrect,  or if otherwise  required by
applicable law or regulation related to money laundering similar activities, the
Company may undertake  appropriate  actions to ensure compliance with



                                       12


applicable  law or regulation,  including but not limited to segregation  and/or
redemption of the Purchaser's  investment in the Company.  The Purchaser further
understands  that the  Company may release  confidential  information  about the
Purchaser  and, if  applicable,  any  underlying  beneficial  owners,  to proper
authorities if the Company, in its sole discretion, determines that it is in the
best interests of the Company in light of relevant rules and  regulations  under
the laws set forth in subsection (ii) above.

             5.9  Reoffers  and  Resales.   Purchaser  will  not,   directly  or
indirectly,  offer, sell,  pledge,  transfer or otherwise dispose of (or solicit
any offers to buy, purchase or otherwise acquire or take a pledge of) any of the
Securities  unless  registered  under  the  Securities  Act  or  pursuant  to an
exemption from registration under the Securities Act.

             5.10 No  Advertisement,  Etc.  Purchaser is not subscribing for the
Securities as a result of, or pursuant to, any advertisement, article, notice or
other  communication  published in any  newspaper,  magazine or similar media or
broadcast  over  television  or radio or  presented  at any  seminar or meeting.
Purchaser  understands that no United States federal or state agency, or similar
agency of any other  country,  has  passed  upon or made any  recommendation  or
endorsement of the Company, this transaction or the purchase of the Securities.

             5.11 Company  Reliance.  Purchaser  understands that the Securities
are being  offered and sold to the Purchaser by the Company in reliance upon the
truth and accuracy of, and the Purchaser's compliance with, the representations,
warranties, agreements,  acknowledgments and understandings of the Purchaser set
forth herein and in the documents  contemplated in connection  herewith in order
to determine the  eligibility of the Purchaser to acquire or receive an offer to
acquire  the  Securities;  and the  information  with  respect to the  Purchaser
provided  to the  Company by the  Purchaser  is  accurate  and  complete  in all
material respects.

             5.12 Legends.

                  (a) The Note shall bear substantially the following legend:

             "THIS NOTE AND THE COMMON STOCK ISSUABLE UPON  CONVERSION
             OF  THIS  NOTE  HAVE  NOT  BEEN   REGISTERED   UNDER  THE
             SECURITIES  ACT OF 1933, AS AMENDED,  OR ANY  APPLICABLE,
             STATE  SECURITIES  LAWS.  THIS NOTE AND THE COMMON  STOCK
             ISSUABLE  UPON  CONVERSION  OF THIS NOTE MAY NOT BE SOLD,
             OFFERED FOR SALE,  PLEDGED OR HYPOTHECATED IN THE ABSENCE
             OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THIS NOTE OR
             SUCH  SHARES   UNDER  SAID  ACT  AND   APPLICABLE   STATE
             SECURITIES  LAWS  OR AN  OPINION  OF  COUNSEL  REASONABLY
             SATISFACTORY  TO  OPHTHALMIC  IMAGING  SYSTEMS  THAT SUCH
             REGISTRATION IS NOT REQUIRED."

                  (b) The Note Shares and the Warrant  Shares,  if not issued by
DWAC system (as hereinafter  defined) in connection with a resale,  shall bear a
legend which shall be in



                                       13


substantially  the following  form until such shares are covered by an effective
registration statement filed with the SEC:

             "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
             REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
             OR ANY APPLICABLE,  STATE  SECURITIES  LAWS. THESE SHARES
             MAY  NOT  BE  SOLD,   OFFERED   FOR  SALE,   PLEDGED   OR
             HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE  REGISTRATION
             STATEMENT UNDER SUCH SECURITIES ACT AND APPLICABLE  STATE
             LAWS OR AN OPINION OF COUNSEL REASONABLY  SATISFACTORY TO
             OPHTHALMIC  IMAGING SYSTEMS THAT SUCH REGISTRATION IS NOT
             REQUIRED."

                  (c) The Warrant shall bear substantially the following legend:

                  "THIS WARRANT AND THE COMMON SHARES ISSUABLE UPON EXERCISE OF
                  THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
                  OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS.
                  THIS WARRANT AND THE COMMON SHARES ISSUABLE UPON EXERCISE OF
                  THIS WARRANT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
                  HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
                  STATEMENT AS TO THIS WARRANT OR THE UNDERLYING SHARES OF
                  COMMON STOCK UNDER SAID ACT AND APPLICABLE STATE SECURITIES
                  LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO
                  OPHTHALMIC IMAGING SYSTEMS THAT SUCH REGISTRATION IS NOT
                  REQUIRED."

         6.  COVENANTS OF THE COMPANY. The Company covenants and agrees with the
Purchaser as follows:

             6.1  Stop-Orders.  The Company will advise the Purchaser,  promptly
after it receives  notice of issuance by the Securities and Exchange  Commission
(the "SEC"), any state securities  commission or any other regulatory  authority
of any stop order or of any order  preventing or suspending  any offering of any
securities  of the Company,  or of the  suspension of the  qualification  of the
Common  Stock of the Company for  offering or sale in any  jurisdiction,  or the
initiation of any proceeding for any such purpose.

             6.2 Listing.  The Company shall promptly  secure the listing of the
shares  of  Common  Stock  issuable  upon  conversion  of the  Note and upon the
exercise  of the  Warrant  on the NASD  Over the  Counter  Bulletin  Board  (the
"Principal  Market")  upon which shares of Common  Stock are listed  (subject to
official  notice of  issuance)  and shall  maintain  such listing so long as any
other shares of Common Stock shall be so listed.  The Company will  maintain the



                                       14


listing of its Common  Stock on the  Principal  Market,  and will  comply in all
material  respects with the Company's  reporting,  filing and other  obligations
under the bylaws or rules of the  National  Association  of  Securities  Dealers
("NASD") and such exchanges, as applicable.

             6.3 Market Regulations.  The Company shall notify the SEC, NASD and
applicable  state  authorities,  in accordance with their  requirements,  of the
transactions  contemplated by this Agreement, and shall take all other necessary
action and  proceedings as may be required and permitted by applicable law, rule
and regulation,  for the legal and valid issuance of the Securities to Purchaser
and promptly provide copies thereof to Purchaser.

             6.4 Reporting  Requirements.  The Company will timely file with the
SEC all reports  required to be filed  pursuant to the  Exchange Act and refrain
from  terminating  its status as an issuer  required by the Exchange Act to file
reports  thereunder  even  if  the  Exchange  Act or the  rules  or  regulations
thereunder would permit such termination.

             6.5 Use of Funds.  The Company agrees that it will use the proceeds
of the sale of the Note and  Warrant  for  general  corporate  purposes  and the
repayment of the Company's indebtedness only.

             6.6   Access  to   Facilities.   The   Company   will   permit  any
representatives designated by the Purchaser (or any successor of the Purchaser),
upon  reasonable  notice and during  normal  business  hours,  at such  person's
expense and  accompanied by a  representative  of the Company,  to (a) visit and
inspect any of the  properties  of the Company,  (b) examine the  corporate  and
financial  records of the Company  (unless such  examination is not permitted by
federal,  state  or local  law or by  contract)  and (c)  discuss  the  affairs,
finances  and  accounts  of  the  Company  with  the  directors,   officers  and
independent accountants of the Company.

             6.7 Taxes. The Company will promptly pay and discharge, or cause to
be paid and discharged,  when due and payable, all lawful taxes, assessments and
governmental  charges or levies  imposed upon the income,  profits,  property or
business  of the  Company;  provided,  however,  that any such tax,  assessment,
charge or levy  need not be paid if the  validity  thereof  shall  currently  be
contested in good faith by appropriate proceedings and if the Company shall have
set aside on its books  adequate  reserves with respect  thereto,  and provided,
further,  that the  Company  will pay all such  taxes,  assessments,  charges or
levies  forthwith  upon the  commencement  of  proceedings to foreclose any lien
which may have attached as security therefor.

             6.8  Insurance.  The Company  will keep its assets  which are of an
insurable  character insured by financially sound and reputable insurers against
loss or damage by fire, explosion and other risks customarily insured against by
companies in similar business similarly situated as the Company; and the Company
will maintain, with financially sound and reputable insurers,  insurance against
other  hazards and risks and liability to persons and property to the extent and
in the manner which the Company  reasonably  believes is customary for companies
in  similar  business  similarly  situated  as the  Company  and  to the  extent
available on commercially reasonable terms.



                                       15


             6.9 Intellectual Property. The Company shall maintain in full force
and effect its corporate  existence,  rights and franchises and all licenses and
other  rights  to  use  Intellectual  Property  owned  or  possessed  by it  and
reasonably deemed to be necessary to the conduct of its business.

             6.10  Properties.  The  Company  will keep its  properties  in good
repair, working order and condition, reasonable wear and tear excepted, and from
time to time  make all  needful  and  proper  repairs,  renewals,  replacements,
additions  and  improvements  thereto;  and the Company will at all times comply
with  each  provision  of all  leases  to which it is a party or under  which it
occupies  property if the breach of such provision could  reasonably be expected
to have a material adverse effect.

             6.11 Confidentiality. The Company agrees that it will not disclose,
and will not  include in any  public  announcement,  the name of the  Purchaser,
unless  expressly agreed to by the Purchaser or unless and until such disclosure
is required by law or applicable regulation, and then only to the extent of such
requirement.

             6.12 Required Approvals. For so long as 25% of the principal amount
of the Note is  outstanding,  the Company,  without the prior written consent of
the Purchaser, shall not:

                  (a) directly or indirectly declare or pay any dividends, other
than dividends with respect to its preferred stock;

                  (b) liquidate, dissolve or effect a material reorganization if
such  material  reorganization  would  result in a change to a  majority  of the
current  composition of the Company's Board of Directors or could  reasonably be
expected to have a material  adverse effect (i) on the ability of the Company to
fully perform its Obligations (as defined in the Security  Agreement between the
Company and the Purchaser of even date herewith (the "Security  Agreement"),  or
(ii) on the value of the  Collateral  (as defined in the Security  Agreement) or
the priority of the Purchaser's liens with respect thereto;

                  (c) become subject to (including,  without limitation,  by way
of amendment to or  modification  of) any agreement or  instrument  which by its
terms would (under any  circumstances)  restrict the Company's  right to perform
the provisions of this Agreement or any of the agreements  contemplated thereby;
or

                  (d)  materially  alter or change the scope of the  business of
the Company.

             6.13 Reissuance  of  Securities.  The  Company  agrees  to  reissue
certificates  representing  the  Securities  without  the  legends  set forth in
Section  5.12  above at such time as (a) the  holder  thereof  is  permitted  to
dispose of such Securities  pursuant to Rule 144(k) under the Securities Act, or
(b) upon  resale  subject  to an  effective  registration  statement  after such
Securities  are  registered  under the  Securities  Act.  The Company  agrees to
cooperate  with the  Purchaser in connection  with all resales  pursuant to Rule
144(d) and Rule  144(k)  and  provide  legal  opinions  necessary  to allow such
resales  provided  the  Company  and its counsel  receive  reasonably  requested
representations from the selling Purchaser and broker, if any.



                                       16


             6.14 Opinion.  On the Closing Date, the Company will deliver to the
Purchaser  an opinion  acceptable  to the  Purchaser  from the  Company's  legal
counsel.  The Company will provide,  at the Company's expense,  such other legal
opinions in the future as are  reasonably  necessary  for the  conversion of the
Note and exercise of the Warrant.

         7. COVENANTS OF THE PURCHASER.  The Purchaser covenants and agrees with
the Company as follows:

             7.1  Confidentiality.   The  Purchaser  agrees  that  it  will  not
disclose,  and will not  include  in any  public  announcement,  the name of the
Company,  unless  expressly  agreed to by the  Company  or unless and until such
disclosure  is required by law or  applicable  regulation,  and then only to the
extent of such requirement.

             7.2 Non-Public Information.  The Purchaser agrees not to effect any
sales in the  shares  of the  Company's  Common  Stock  while in  possession  of
material,  non-public  information  regarding  the  Company if such sales  would
violate applicable securities law.

             7.3 CONDITIONS PRECEDENT.  The obligations hereunder of the Company
and the  Purchaser  to enter  into  this  Agreement  and sell and  purchase  the
Securities is subject to their satisfaction or waiver, at or before the Closing,
of  each  of the  conditions  set  forth  below.  These  conditions  are for the
Company's  and the  Purchaser's  sole benefit  respectively,  and they may waive
their own rights at any time in their sole discretion.

                 (a)  The  parties  shall  have  executed  and  delivered   this
Agreement and the Related Agreements.

                 (b) The Purchaser  shall have delivered to the Escrow Agent the
purchase  price for the Securities and the Company shall have delivered the Note
and the Warrant to the Escrow Agent.

                 (c) Each of the  representations  and warranties of the Company
and the Purchaser  shall be true and correct in all material  respects as of the
Closing  Date,  except for  representations  and  warranties  that speak as of a
particular date, which shall be true and correct in all material  respects as of
such date.

                 (d) The Company shall have performed, satisfied and complied in
all respects with all  covenants,  agreements  and  conditions  required by this
Agreement to be performed, satisfied or complied with by the Company at or prior
to the Closing Date.

                 (e) At the  Closing,  the  Purchaser  shall  have  received  an
opinion of counsel to the Company,  dated the date of such Closing,  in the form
of Exhibit C hereto.

                 (f) All fees and expenses required to be paid by the Company in
accordance with the provisions of Section 2 hereof shall have been or authorized
to be paid by the Company as of the Closing Date



                                       17


         8.  COVENANTS OF THE COMPANY AND PURCHASER REGARDING
             INDEMNIFICATION.

             8.1 Company Indemnification.  The Company agrees to indemnify, hold
harmless,   reimburse  and  defend  Purchaser,  each  of  Purchaser's  officers,
directors,  agents,  affiliates,  control persons,  and principal  shareholders,
against  any  claim,  cost,  expense,  liability,  obligation,  loss  or  damage
(including reasonable legal fees) of any nature, incurred by or imposed upon the
Purchaser   which   results,   arises   out  of  or  is   based   upon  (i)  any
misrepresentation  by  Company  or breach of any  warranty  by  Company  in this
Agreement  or in any  exhibits  or  schedules  attached  hereto  or any  Related
Agreement,  or (ii) any  breach or  default  in  performance  by  Company of any
covenant or  undertaking  to be  performed  by Company  hereunder,  or any other
agreement entered into by the Company and Purchaser relating hereto.

             8.2  Purchaser's  Indemnification.  Purchaser  agrees to indemnify,
hold  harmless,  reimburse  and defend  the  Company  and each of the  Company's
officers,   directors,   agents,  affiliates,   control  persons  and  principal
shareholders,  at  all  times  against  any  claim,  cost,  expense,  liability,
obligation,  loss or damage  (including  reasonable  legal  fees) of any nature,
incurred by or imposed upon the Company which results, arises out of or is based
upon (i) any  misrepresentation  by  Purchaser  or  breach  of any  warranty  by
Purchaser in this Agreement or in any exhibits or schedules  attached  hereto or
any Related Agreement; or (ii) any breach or default in performance by Purchaser
of any covenant or  undertaking to be performed by Purchaser  hereunder,  or any
other agreement entered into by the Company and Purchaser relating hereto.

             8.3 Procedures. The procedures and limitations set forth in Section
11.2(c) and (d) shall apply to the  indemnifications  set forth in Sections  9.1
and 9.2 above.

         9.  CONVERSION OF CONVERTIBLE NOTE.

             9.1 Mechanics of Conversion.

                 (a)  Provided  the  Purchaser  has  notified the Company of the
Purchaser's  intention  to sell the Note Shares and the Note Shares are included
in an effective registration statement or are otherwise exempt from registration
when sold:  (i) Upon the  conversion  of the Note or part  thereof,  the Company
shall,  at its own cost and expense,  take all necessary  action  (including the
issuance of an opinion of counsel) to assure that the Company's  transfer  agent
shall issue shares of the  Company's  Common Stock in the name of the  Purchaser
(or its  nominee)  or such  other  persons as  designated  by the  Purchaser  in
accordance with Section 10.1(b) hereof and in such denominations to be specified
representing the number of Note Shares issuable upon such  conversion;  and (ii)
The Company  warrants that no instructions  other than these  instructions  have
been or will be given to the transfer  agent of the  Company's  Common Stock and
that after the Effective  Date (as  hereinafter  defined) the Note Shares issued
will be freely transferable  subject to the prospectus delivery  requirements of
the Securities Act and the provisions of this Agreement,  and will not contain a
legend restricting the resale or transferability of the Note Shares.

                 (b) Purchaser  will give notice of its decision to exercise its
right to convert the Note or part thereof by telecopying or otherwise delivering
an executed and completed  notice



                                       18


of the  number  of  shares  to be  converted  to the  Company  (the  "Notice  of
Conversion"). The Purchaser will not be required to surrender the Note until the
Purchaser  receives a credit to the  account  of the  Purchaser's  prime  broker
through  the DWAC  system (as defined  below),  representing  the Note Shares or
until  the  Note has  been  fully  satisfied.  Each  date on  which a Notice  of
Conversion  is  telecopied  or delivered to the Company in  accordance  with the
provisions  hereof shall be deemed a  "Conversion  Date." The Company will cause
the transfer agent to transmit the shares of the Company's Common Stock issuable
upon conversion of the Note (and a certificate  representing  the balance of the
Note not so converted,  if requested by Purchaser) to the Purchaser by crediting
the account of the  Purchaser's  prime broker with the Depository  Trust Company
("DTC") through its Deposit  Withdrawal Agent Commission  ("DWAC") system within
three (3) business days after receipt by the Company of the Notice of Conversion
(the  "Delivery  Date")  so long as such  Common  Stock  being  converted  is in
connection with a resale by the Purchaser.

                 (c) The Company understands that a delay in the delivery of the
Note  Shares  in the form  required  pursuant  to  Section 9 hereof  beyond  the
Delivery Date could result in economic loss to the Purchaser.  In the event that
the Company fails to direct its transfer agent to deliver the Note Shares to the
Purchaser via the DWAC system within the time frame set forth in Section 10.1(b)
above and the Note Shares are not  delivered  to the  Purchaser  by the Delivery
Date, as  compensation to the Purchaser for such loss, the Company agrees to pay
late  payments to the Purchaser for late issuance of the Note Shares in the form
required pursuant to Section 10 hereof upon conversion of the Note in the amount
equal to the greater of (i) $500 per  business  day after the  Delivery  Date or
(ii) the Purchaser's actual damages from such delayed delivery.  Notwithstanding
the  foregoing,  the Company will not owe the Purchaser any late payments if the
delay in the delivery of the Note Shares  beyond the Delivery Date is solely out
of the control of the  Company  and the  Company is actively  trying to cure the
cause of the delay.  The  Company  shall pay any  payments  incurred  under this
Section in  immediately  available  funds upon demand and, in the case of actual
damages,  accompanied by reasonable documentation of the amount of such damages.
Such documentation shall show the number of shares of Common Stock the Purchaser
is  forced to  purchase  (in an open  market  transaction)  which the  Purchaser
anticipated  receiving  upon such  conversion,  and shall be  calculated  as the
amount by which (A) the Purchaser's  total purchase price  (including  customary
brokerage  commissions,  if any) for the  shares  of Common  Stock so  purchased
exceeds (B) the aggregate  principal  and/or  interest  amount of the Note,  for
which such Conversion Notice was not timely honored.

                 Nothing  contained herein or in any document referred to herein
or delivered in connection  herewith shall be deemed to establish or require the
payment  of a rate of  interest  or  other  charges  in  excess  of the  maximum
permitted by applicable law. In the event that the rate of interest or dividends
required  to be paid or  other  charges  hereunder  exceed  the  maximum  amount
permitted by such law, any payments in excess of such maximum  shall be credited
against  amounts  owed by the  Company to a Purchaser  and thus  refunded to the
Company.

             10.2 Maximum  Conversion.  The  Purchaser  shall not be entitled to
convert on a Conversion  Date, nor shall the Company be permitted to require the
Purchaser  to accept,  that amount of a Note in  connection  with that number of
shares of Common  Stock which would be in excess of the sum of (i) the number of
shares of Common Stock beneficially owned by the Purchaser on a Conversion Date,
and (ii) the number of shares of Common Stock  issuable



                                       19


upon the conversion of the Note with respect to which the  determination of this
proviso is being made on a Conversion  Date,  which would  result in  beneficial
ownership  by the  Purchaser  of more than  4.99% of the  outstanding  shares of
Common  Stock of the Company on such  Conversion  Date.  For the purposes of the
immediately  preceding  sentence,  beneficial  ownership  shall be determined in
accordance  with  Section  13(d)  of  the  Exchange  Act  and  Regulation  13d-3
thereunder.  The Purchaser may void the conversion  limitation described in this
Section  10.2 upon seventy five (75) days prior notice to the Company or without
any notice  requirement  upon an Event of Default  (as  defined in the Note) and
this conversion limitation shall become null and void.

         10. REGISTRATION RIGHTS.

                 Registration   Rights   Granted.   The  Company  hereby  grants
registration rights to the Purchaser pursuant to a Registration Rights Agreement
dated as of even date herewith between the Company and the Purchaser.

             10.1 OFFERING  RESTRICTIONS.  Except as previously disclosed in the
SEC Reports or in the Exchange Act Filings, or stock or stock options granted to
employees or directors  of the Company;  or shares of preferred  stock issued to
pay dividends in respect of the  Company's  preferred  stock;  or equity or debt
issued in connection with an acquisition of a business or assets by the Company;
or the issuance by the Company of stock in connection with the  establishment of
a  joint  venture   partnership  or  licensing   arrangement  (these  exceptions
hereinafter referred to as the "Excepted Issuances"), the Company will not issue
any securities with a continuously  variable/floating  conversion  feature which
are or could be (by conversion or  registration)  free-trading  securities (i.e.
common stock subject to a registration statement) prior to the full repayment or
conversion of the Note (the "Exclusion Period").

         11. MISCELLANEOUS.

             11.1  Governing  Law.  THIS  AGREEMENT  SHALL  BE  GOVERNED  BY AND
CONSTRUED IN ACCORDANCE  WITH THE LAWS OF THE STATE OF NEW YORK,  WITHOUT REGARD
TO PRINCIPLES OF CONFLICTS OF LAWS.  ANY ACTION  BROUGHT BY EITHER PARTY AGAINST
THE OTHER  CONCERNING THE  TRANSACTIONS  CONTEMPLATED BY THIS AGREEMENT SHALL BE
BROUGHT ONLY IN THE STATE COURTS OF NEW YORK OR IN THE FEDERAL COURTS LOCATED IN
THE STATE OF NEW YORK. BOTH PARTIES AND THE INDIVIDUALS EXECUTING THIS AGREEMENT
AND  OTHER  AGREEMENTS  ON  BEHALF  OF  THE  COMPANY  AGREE  TO  SUBMIT  TO  THE
JURISDICTION  OF SUCH  COURTS  AND WAIVE  TRIAL BY JURY.  IN THE EVENT  THAT ANY
PROVISION OF THIS  AGREEMENT  OR ANY OTHER  AGREEMENT  DELIVERED  IN  CONNECTION
HEREWITH IS INVALID OR  UNENFORCEABLE  UNDER ANY  APPLICABLE  STATUTE OR RULE OF
LAW, THEN SUCH PROVISION  SHALL BE DEEMED  INOPERATIVE TO THE EXTENT THAT IT MAY
CONFLICT  THEREWITH AND SHALL BE DEEMED MODIFIED TO CONFORM WITH SUCH STATUTE OR
RULE OF LAW. ANY SUCH PROVISION WHICH MAY PROVE INVALID OR  UNENFORCEABLE  UNDER
ANY LAW SHALL NOT AFFECT THE VALIDITY OR  ENFORCEABILITY  OF ANY OTHER PROVISION
OF ANY AGREEMENT.



                                       20


             11.2  Survival.  The  representations,  warranties,  covenants  and
agreements made herein shall survive any investigation made by the Purchaser and
the  closing of the  transactions  contemplated  hereby to the  extent  provided
therein.  All statements as to factual  matters  contained in any certificate or
other  instrument  delivered by or on behalf of the Company  pursuant  hereto in
connection  with the  transactions  contemplated  hereby  shall be  deemed to be
representations and warranties by the Company hereunder solely as of the date of
such certificate or instrument.

             11.3 Successors. Except as otherwise expressly provided herein, the
provisions  hereof  shall  inure to the  benefit  of, and be binding  upon,  the
successors,  heirs, executors and administrators of the parties hereto and shall
inure to the benefit of and be  enforceable by each person who shall be a holder
of the  Securities  from time to time,  other than the  holders of Common  Stock
which  has been  sold by the  Purchaser  pursuant  to Rule  144 or an  effective
registration  statement.  Purchaser  may not assign its  rights  hereunder  to a
competitor of the Company  Notwithstanding the foregoing,  any assignee shall be
bound by the terms and provisions of this Agreement. .

             11.4 Entire Agreement.  This Agreement,  the exhibits and schedules
hereto, the Related Agreements and the other documents delivered pursuant hereto
constitute the full and entire  understanding  and agreement between the parties
with regard to the subjects  hereof and no party shall be liable or bound to any
other in any manner by any representations, warranties, covenants and agreements
except as specifically set forth herein and therein.

             11.5 Severability.  In case any provision of the Agreement shall be
invalid, illegal or unenforceable,  the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

             11.6 Amendment and Waiver.

                  (a) This  Agreement  may be amended or modified  only upon the
written consent of the Company and the Purchaser.

                  (b) The  obligations  of the  Company  and the  rights  of the
Purchaser  under this  Agreement may be waived only with the written  consent of
the Purchaser.

                  (c) The  obligations  of the  Purchaser  and the rights of the
Company under this Agreement may be waived only with the written  consent of the
Company.

             11.7 Delays or Omissions. It is agreed that no delay or omission to
exercise  any right,  power or remedy  accruing  to any party,  upon any breach,
default or  noncompliance  by another party under this  Agreement or the Related
Agreements,  shall  impair  any such  right,  power or  remedy,  nor shall it be
construed to be a waiver of any such breach,  default or  noncompliance,  or any
acquiescence  therein, or of or in any similar breach,  default or noncompliance
thereafter occurring. All remedies, either under this Agreement, the Note or the
Related  Agreements,  by law  or  otherwise  afforded  to any  party,  shall  be
cumulative and not alternative.



                                       21


             11.8 Notices.  All notices required or permitted hereunder shall be
in writing and shall be deemed  effectively given: (a) upon personal delivery to
the party to be notified,  (b) when sent by  confirmed  facsimile if sent during
normal  business hours of the recipient,  if not, then on the next business day,
(c) three (3) business  days after having been sent by  registered  or certified
mail, return receipt  requested,  postage prepaid,  or (d) one day after deposit
with a nationally  recognized  overnight courier,  specifying next day delivery,
with written  verification of receipt.  All communications  shall be sent to the
Company at the address as set forth on the signature  page hereof with a copy to
Henry I.  Rothman,  Esq.  Jenkens & Gilchrist  Parker  Chapin LLP 405  Lexington
Avenue New York, NY 10174 facsimile  number (212) 704-6288,  to the Purchaser at
the address set forth on the signature  page hereto for such  Purchaser,  with a
copy in the case of the Purchaser to John E. Tucker, Esq., 825 Third Avenue 14th
Floor,  New York, NY 10022,  facsimile  number (212) 541-4434,  or at such other
address as the Company or the Purchaser  may designate by written  notice to the
other parties hereto given in accordance herewith.

             11.9  Attorneys'  Fees.  In the  event  that any suit or  action is
instituted to enforce any provision in this Agreement,  the prevailing  party in
such dispute shall be entitled to recover from the losing party all fees,  costs
and  expenses  of  enforcing  any right of such  prevailing  party under or with
respect to this Agreement,  including,  without limitation, such reasonable fees
and  expenses  of  attorneys  and  accountants,  which  shall  include,  without
limitation, all fees, costs and expenses of appeals.

             11.10  Titles  and  Subtitles.  The  titles  of  the  sections  and
subsections  of the Agreement are for  convenience of reference only and are not
to be considered in construing this Agreement.

             11.11  Facsimile  Signatures;  Counterparts.  This Agreement may be
executed by  facsimile  signatures  and in any number of  counterparts,  each of
which shall be an  original,  but all of which  together  shall  constitute  one
instrument.

             11.12 Broker's Fees.  Except as set forth on Schedule 12.12 hereof,
each party hereto  represents  and warrants  that no agent,  broker,  investment
banker,  person or firm acting on behalf of or under the authority of such party
hereto is or will be  entitled  to any  broker's  or  finder's  fee or any other
commission   directly  or  indirectly  in  connection   with  the   transactions
contemplated  herein.  Each party hereto  further agrees to indemnify each other
party for any  claims,  losses or  expenses  incurred  by such other  party as a
result of the representation in this Section 12.12 being untrue.

             11.13 Construction.  Each party acknowledges that its legal counsel
participated  in the  preparation of this  Agreement and the Related  Agreements
and, therefore, stipulates that the rule of construction that ambiguities are to
be  resolved   against  the   drafting   party  shall  not  be  applied  in  the
interpretation of this Agreement to favor any party against the other.




                                       22




         IN WITNESS WHEREOF, the parties hereto have executed the SECURITIES
PURCHASE AGREEMENT as of the date set forth in the first paragraph hereof.


COMPANY:                                  PURCHASER:

OPHTHALMIC IMAGING SYSTEMS                LAURUS MASTER FUND, LTD.

By:_________________________________      By:__________________________________
Name:_______________________________      Name:_______________________________
Title:______________________________      Title:________________________________
Address:   221 Lathrop Way, Suite I       Address: c/o Ironshore Corporate
           Sacramento, CA 95815                    Services Ltd.
Attention: Chief Financial Officer                 P.O. Box 1234  G.T.,
Facsimile: (916) 646-0207                          Queensgate  House,  South
                                                   Church Street
                                                   Grand Cayman, Cayman Islands









                                LIST OF EXHIBITS


Form of  Convertible Term Note                                 Exhibit A

Form of Warrant                                                Exhibit B

Form of Opinion                                                Exhibit C

Form of Escrow Agreement                                       Exhibit D


















                                    EXHIBIT A

                            FORM OF CONVERTIBLE NOTE





















                                      A-1




                                    EXHIBIT B

                                 Form of warrant






















                                      B-1




                                    EXHIBIT C


                                 FORM OF OPINIoN


         1. The Company is a corporation  validly  existing and in good standing
under the laws of the State of Delaware and has all  requisite  corporate  power
and  authority  to own,  operate  and lease its  properties  and to carry on its
business as it is now being conducted.

         2. The Company  has the  requisite  corporate  power and  authority  to
execute,  deliver and perform its  obligations  under the  Agreement and Related
Agreements.  All  corporate  action on the part of the Company and its officers,
directors and stockholders necessary has been taken for (i) the authorization of
the Agreement and Related  Agreements and the  performance of all obligations of
the  Company  thereunder  at the  Closing,  and  (ii) the  authorization,  sale,
issuance  and  delivery  of the  Securities  pursuant to the  Agreement  and the
Related Agreements. The Note Shares and the Warrant Shares, when issued pursuant
to and in accordance  with the terms of the Agreement and the Related  Documents
and upon delivery  shall be validly issued and  outstanding,  fully paid and non
assessable.

         3. The execution,  delivery and performance of the Agreement,  the Note
or  the  Related   Agreements  by  the  Company  and  the  consummation  of  the
transactions on its part contemplated by any thereof,  will not, with or without
the giving of notice or the passage of time or both:

                           (a) Violate the provisions of the Charter or bylaws
of the company; or

                           (b) To the best of such counsel's knowledge, violate
                  any judgment, decree, order or award of any court binding upon
                  the Company.

         4. The  Agreement and Related  Agreements  will  constitute,  valid and
legally  binding  obligations of the Company,  and are  enforceable  against the
Company in  accordance  with their  respective  terms,  except (a) as limited by
applicable bankruptcy, insolvency,  reorganization,  moratorium or other laws of
general application  affecting enforcement of creditors' rights, and (b) general
principles  of equity that  restrict  the  availability  of  equitable  or legal
remedies.

         5. To such counsel's knowledge, the sale of the Note and the subsequent
conversion of the Note into Note Shares are not subject to any preemptive rights
or rights of first refusal that have not been properly  waived or complied with.
To such counsel's knowledge, the sale of the Warrant and the subsequent exercise
of the Warrant for Warrant Shares are not subject to any  preemptive  rights or,
to such counsel's knowledge, rights of first refusal that have not been properly
waived or complied with.

         6. Assuming the accuracy of the  representations  and warranties of the
Purchaser  contained  in the  Agreement,  the offer,  sale and  issuance  of the
Securities on the Closing Date will be exempt from the registration requirements
of the Securities Act. To such


                                      C-1


counsel's  knowledge,  neither the Company,  nor any of its affiliates,  nor any
person acting on its or their behalf, has directly or indirectly made any offers
or sales of any  security  or  solicited  any offers to buy and  security  under
circumstances  that would cause the offering of the Securities  pursuant to this
Agreement to be integrated  with prior  offerings by the Company for purposes of
the  Securities  Act which would prevent the Company from selling the Securities
pursuant   to  Rule  506   under  the   Securities   Act,   or  any   applicable
exchange-related stockholder approval provisions.

         7. There is no action, suit, proceeding or investigation pending or, to
such counsel's knowledge, currently threatened against the Company that prevents
the right of the  Company to enter  into this  Agreement  or any of the  Related
Agreements,  or to consummate the  transactions  contemplated  thereby.  To such
counsel's knowledge,  the Company is not a party or subject to the provisions of
any  order,  writ,  injunction,  judgment  or decree of any court or  government
agency  or  instrumentality;  nor is  there  any  action,  suit,  proceeding  or
investigation by the Company  currently  pending or which the Company intends to
initiate.



















                                      C-2