REGISTRATION RIGHTS AGREEMENT

         This  Registration  Rights  Agreement  (this  "Agreement")  is made and
entered into as of  September  25th,  2003,  by and between  Ophthalmic  Imaging
Systems., a California corporation (the "Company"), and Laurus Master Fund, Ltd.
(the "Purchaser").

         This Agreement is made pursuant to the Securities  Purchase  Agreement,
dated as of the date hereof,  by and between the  Purchaser and the Company (the
"Securities  Purchase  Agreement"),  and  pursuant to the Note and the  Warrants
referred to therein.

         The Company and the Purchaser hereby agree as follows:

     1.  DEFINITIONS.  Capitalized  terms used and not otherwise  defined herein
that are defined in the Securities  Purchase  Agreement  shall have the meanings
given  such  terms  in the  Securities  Purchase  Agreement.  As  used  in  this
Agreement, the following terms shall have the following meanings:

         "Commission" means the Securities and Exchange Commission.

         "Common Stock" means shares of the Company's common stock, no par value
per share.

         "Effectiveness Date" means the 120th day following the Filing Date.

         "Effectiveness  Period"  shall  have the  meaning  set forth in Section
2(a).

         "Exchange Act" means the  Securities  Exchange Act of 1934, as amended,
and any successor statute.

         "Filing  Date"  means,  with  respect  to  the  Registration  Statement
required  to be filed  hereunder,  a date no later  than  forty  five  (45) days
following  the date  upon  which  the  principal  amount of the Term Loan to the
Company  in  original  principal  amount of  $1,200,000  has been  funded to the
Company.

         "Holder" or "Holders"  means the Purchaser or any of its  affiliates or
transferees to the extent any of them hold Registrable Securities.

         "Indemnified Party" shall have the meaning set forth in Section 5(c).

         "Indemnifying Party" shall have the meaning set forth in Section 5(c).

         "Note" has the meaning set forth in the Securities Purchase Agreement.

         "Proceeding" means an action, claim, suit,  investigation or proceeding
(including,  without limitation, an investigation or partial proceeding, such as
a deposition), whether commenced or threatened.





         "Prospectus"   means  the  prospectus   included  in  the  Registration
Statement  (including,  without  limitation,  a  prospectus  that  includes  any
information  previously  omitted from a prospectus filed as part of an effective
registration  statement  in  reliance  upon  Rule  430A  promulgated  under  the
Securities Act), as amended or supplemented by any prospectus  supplement,  with
respect  to  the  terms  of  the  offering  of any  portion  of the  Registrable
Securities covered by the Registration  Statement,  and all other amendments and
supplements to the  Prospectus,  including  post-effective  amendments,  and all
material  incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

         "Registrable Securities" means the shares of Common Stock issuable upon
the conversion of the Note and issuable upon exercise of the Warrants.

         "Registration  Statement" means each registration statement required to
be filed hereunder, including the Prospectus, amendments and supplements to such
registration   statement  or  Prospectus,   including  pre-  and  post-effective
amendments,  all exhibits thereto, and all material incorporated by reference or
deemed to be incorporated by reference in such registration statement.

         "Rule 144" means Rule 144 promulgated by the Commission pursuant to the
Securities  Act, as such Rule may be amended  from time to time,  or any similar
rule or regulation  hereafter adopted by the Commission having substantially the
same effect as such Rule.

         "Rule 415" means Rule 415 promulgated by the Commission pursuant to the
Securities  Act, as such Rule may be amended  from time to time,  or any similar
rule or regulation  hereafter adopted by the Commission having substantially the
same effect as such Rule.

         "Rule 424" means Rule 424 promulgated by the Commission pursuant to the
Securities  Act, as such Rule may be amended  from time to time,  or any similar
rule or regulation  hereafter adopted by the Commission having substantially the
same effect as such Rule.

         "Securities Act" means the Securities Act of 1933, as amended,  and any
successor statute.

         "Trading  Market"  means  any of the NASD OTC  Bulletin  Board,  NASDAQ
SmallCap Market,  the Nasdaq National Market, the American Stock Exchange or the
New York Stock Exchange.

         "Warrants" means the Common Stock purchase  warrants issued pursuant to
the Security Agreement.

     2.  REGISTRATION.

         (a) On or prior to the Filing Date the Company  shall  prepare and file
with the Commission a Registration Statement covering the Registrable Securities
for an  offering to be made on a  continuous  basis  pursuant  to Rule 415.  The
Registration  Statement shall be on Form S-B2 (except if the Company is not then
eligible to register  for resale the  Registrable  Securities  on Form S-B2,  in
which case such registration shall be on another  appropriate form in accordance
herewith).  The  Company  shall  cause  the  Registration  Statement  to  become
effective



                                       2


and remain  effective as provided  herein.  The Company shall use its reasonable
commercial efforts to cause the Registration  Statement to be declared effective
under the Securities Act as promptly as possible after the filing  thereof,  but
in any event no later than the  Effectiveness  Date.  The Company  shall use its
reasonable  commercial efforts to keep the Registration  Statement  continuously
effective  under the  Securities Act until the date which is the earlier date of
when (i) all  Registrable  Securities  have  been  sold or (ii) all  Registrable
Securities may be sold immediately without registration under the Securities Act
and without volume  restrictions  pursuant to Rule 144(k),  as determined by the
counsel to the Company  pursuant  to a written  opinion  letter to such  effect,
addressed  and  acceptable  to the  Company's  transfer  agent and the  affected
Holders (the "Effectiveness Period").

         (b) If: (i) the Registration  Statement is not filed on or prior to the
Filing Date; (ii) the  Registration  Statement is not declared  effective by the
Commission by the Effectiveness Date; (iii) after the Registration  Statement is
filed with and declared effective by the Commission,  the Registration Statement
ceases to be  effective  (by  suspension  or  otherwise)  as to all  Registrable
Securities to which it is required to relate at any time prior to the expiration
of  the  Effectiveness  Period  (without  being  succeeded   immediately  by  an
additional  registration statement filed and declared effective) for a period of
time  which  shall  exceed  30 days in the  aggregate  per year or more  than 20
consecutive  calendar  days  (defined as a period of 365 days  commencing on the
date the Registration Statement is declared effective); or (iv) the Common Stock
is not listed or quoted,  or is suspended from trading on any Trading Market for
a period of three (3)  consecutive  Trading Days (provided the Company shall not
have been  able to cure such  trading  suspension  within 30 days of the  notice
thereof or list the Common Stock on another Trading  Market);  (any such failure
or breach  being  referred to as an "Event,"  and for  purposes of clause (i) or
(ii) the date on which such Event  occurs,  or for  purposes of clause (iii) the
date  which  such 30 day or 20  consecutive  day  period (as the case may be) is
exceeded,  or for  purposes  of  clause  (iv) the date on which  such  three (3)
Trading Day period is  exceeded,  being  referred to as "Event  Date"  provided,
however,  that with respect to the Event Date  referred to in clause (ii) above,
the Event Date shall be extended  for such time that the  Effectiveness  Date is
delayed as a direct result of the Company receiving comments to the Registration
Statement  from the Commission  that delays  effectiveness  of the  Registration
Statement  so long as the Company in  consultation  with  Holder,  has  promptly
responded to the  Commission's  comments),  then until the  applicable  Event is
cured,  the Company  shall pay to each Holder an amount in cash,  as  liquidated
damages  and not as a  penalty,  equal to 1.5% for each  thirty  (30) day period
(prorated for partial periods) on a daily basis of the original principal amount
of the Note. While such Event continues,  such liquidated  damages shall be paid
not less often than each thirty (30) days. Any unpaid  liquidated  damages as of
the date when an Event has been cured by the Company  shall be paid within three
(3) days following the date on which such Event has been cured by the Company.

     3.  REGISTRATION PROCEDURES. If and whenever the Company is required by the
provisions hereof to effect the registration of any Registrable Securities under
the Securities Act, the Company will, as expeditiously as possible:

         (a) prepare and file with the  Commission  the  Registration  Statement
with respect to such Registrable Securities,  respond as promptly as possible to
any comments received from the Commission, and use its best efforts to cause the
Registration  Statement  to become and



                                       3


remain effective for the Effectiveness Period with respect thereto, and promptly
provide to the Purchaser copies of all filings and Commission letters of comment
relating thereto;

         (b)  prepare  and  file  with  the  Commission   such   amendments  and
supplements to the Registration  Statement and the Prospectus used in connection
therewith as may be necessary to comply with the  provisions  of the  Securities
Act with respect to the disposition of all Registrable Securities covered by the
Registration  Statement and to keep such Registration  Statement effective until
the expiration of the Effectiveness Period;

         (c) furnish to the Purchaser such number of copies of the  Registration
Statement  and the  Prospectus  included  therein  (including  each  preliminary
Prospectus)  as the Purchaser  reasonably  may request to facilitate  the public
sale or disposition of the Registrable  Securities  covered by the  Registration
Statement;

         (d) use its commercially  reasonable efforts to register or qualify the
Purchaser's  Registrable  Securities covered by the Registration Statement under
the securities or "blue sky" laws of such jurisdictions within the United States
as the Purchaser may reasonably  request,  provided,  however,  that the Company
shall not for any such  purpose be  required  to qualify  generally  to transact
business  as a  foreign  corporation  in  any  jurisdiction  where  it is not so
qualified or to consent to general service of process in any such jurisdiction;

         (e)  list  the  Registrable  Securities  covered  by  the  Registration
Statement with any securities  exchange on which the Common Stock of the Company
is then listed;

         (f)  immediately  notify the  Purchaser  at any time when a  Prospectus
relating  thereto is required to be delivered  under the Securities  Act, of the
happening  of any event of which the Company has  knowledge as a result of which
the  Prospectus  contained in such  Registration  Statement,  as then in effect,
includes  an untrue  statement  of a material  fact or omits to state a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading in light of the circumstances then existing; and

         (g) make  available  for  inspection by the Purchaser and any attorney,
accountant or other agent  retained by the  Purchaser,  all publicly  available,
non-confidential  financial and other records, pertinent corporate documents and
properties  of the Company,  and cause the  Company's  officers,  directors  and
employees  to  supply  all  publicly  available,   non-confidential  information
reasonably requested by the attorney, accountant or agent of the Purchaser.



                                       4


     4. REGISTRATION EXPENSES. All expenses relating to the Company's compliance
with Sections 2 and 3 hereof,  including,  without limitation,  all registration
and filing  fees,  printing  expenses,  fees and  disbursements  of counsel  and
independent  public  accountants for the Company,  fees and expenses  (including
reasonable  counsel  fees)  incurred in  connection  with  complying  with state
securities  or "blue  sky"  laws,  fees of the  NASD,  transfer  taxes,  fees of
transfer agents and registrars,  are called "Registration Expenses". All selling
commissions applicable to the sale of Registrable Securities, including any fees
and disbursements of any special counsel to the Holders beyond those included in
Registration  Expenses, are called "Selling Expenses." The Company shall only be
responsible for all Registration Expenses.

     5.  INDEMNIFICATION.

         (a) In the event of a registration of any Registrable  Securities under
the  Securities Act pursuant to this  Agreement,  the Company will indemnify and
hold harmless the Purchaser, and its officers,  directors and each other person,
if any, who controls the  Purchaser  within the meaning of the  Securities  Act,
against any losses, claims,  damages or liabilities,  joint or several, to which
the  Purchaser,  or such persons may become  subject under the Securities Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect  thereof) arise out of or are based upon any untrue statement or alleged
untrue  statement of any material fact contained in any  Registration  Statement
under which such Registrable Securities were registered under the Securities Act
pursuant to this  Agreement,  any  preliminary  Prospectus  or final  Prospectus
contained therein,  or any amendment or supplement  thereof,  or arise out of or
are based upon the omission or alleged omission to state therein a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  and will  reimburse  the  Purchaser,  and each such  person for any
reasonable  legal  or  other  expenses  incurred  by  them  in  connection  with
investigating or defending any such loss,  claim,  damage,  liability or action;
provided,  however,  that the Company will not be liable in any such case if and
to the extent that any such loss, claim, damage or liability arises out of or is
based upon an untrue  statement  or alleged  untrue  statement  or  omission  or
alleged  omission so made in  conformity  with  information  furnished  by or on
behalf of the  Purchaser or any such person in writing  specifically  for use in
any such document. Notwithstanding the provisions of this paragraph, the Company
shall  not be  required  to  indemnify  any  person  or  entity in excess of the
Obligations (as such term is defined in that certain Security Agreement dated as
of the dated as of the date hereof between Holder and Company) unless such claim
for  indemnification  is made  as a  result  of the  gross  negligence,  willful
misconduct or fraudulent action on the part of the Company.

         (b) In the event of a registration of the Registrable  Securities under
the Securities Act pursuant to this Agreement,  the Purchaser will indemnify and
hold harmless the Company, and its officers, directors and each other person, if
any, who controls the Company within the meaning of the Securities Act,  against
all losses,  claims,  damages or  liabilities,  joint or  several,  to which the
Company  or  such  persons  may  become  subject  under  the  Securities  Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect  thereof) arise out of or are based upon any untrue statement or alleged
untrue  statement  of any  material  fact which was  furnished in writing by the
Purchaser to the Company expressly for use in (and such information is contained
in) the  Registration  Statement  under which such  Registrable  Securities were
registered under the Securities Act pursuant to this Agreement,  any preliminary
Prospectus or final Prospectus contained therein, or any amendment or supplement
thereof,  or



                                       5


arise out of or are based upon the omission or alleged omission to state therein
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements therein not misleading,  and will reimburse the Company and each such
person for any reasonable legal or other expenses incurred by them in connection
with  investigating  or defending  any such loss,  claim,  damage,  liability or
action, provided, however, that the Purchaser will be liable in any such case if
and only to the extent that any such loss, claim, damage or liability arises out
of or is based upon an untrue  statement or alleged untrue statement or omission
or alleged omission so made in conformity with information  furnished in writing
to the Company by or on behalf of the Purchaser specifically for use in any such
document.  Notwithstanding the provisions of this paragraph, the Purchaser shall
not be required to indemnify any person or entity in excess of the amount of the
aggregate  net  proceeds  received by the  Purchaser  in respect of  Registrable
Securities in connection with any such registration under the Securities Act.

         (c) Promptly after receipt by a party entitled to claim indemnification
hereunder (an "Indemnified  Party") of notice of the commencement of any action,
such Indemnified Party shall, if a claim for  indemnification in respect thereof
is to be made against a party hereto  obligated  to indemnify  such  Indemnified
Party (an  "Indemnifying  Party"),  notify  the  Indemnifying  Party in  writing
thereof,  but the omission so to notify the Indemnifying Party shall not relieve
it from any  liability  which it may have to such  Indemnified  Party other than
under this Section 5(c) and shall only  relieve it from any  liability  which it
may have to such Indemnified  Party under this Section 5(c) if and to the extent
the Indemnifying  Party is prejudiced by such omission.  In case any such action
shall  be  brought  against  any  Indemnified  Party  and it  shall  notify  the
Indemnifying Party of the commencement  thereof, the Indemnifying Party shall be
entitled  to  participate  in and,  to the extent it shall  wish,  to assume and
undertake  the defense  thereof with counsel  satisfactory  to such  Indemnified
Party,  and, after notice from the Indemnifying  Party to such Indemnified Party
of its election so to assume and undertake the defense thereof, the Indemnifying
Party shall not be liable to such Indemnified  Party under this Section 5(c) for
any legal expenses subsequently incurred by such Indemnified Party in connection
with the defense thereof; if the Indemnified Party retains its own counsel, then
the  Indemnified  Party shall pay all fees,  costs and expenses of such counsel,
provided,  however,  that, if the defendants in any such action include both the
indemnified  party and the  Indemnifying  Party and the Indemnified  Party shall
have reasonably  concluded that there may be reasonable defenses available to it
which are different  from or additional to those  available to the  Indemnifying
Party or if the interests of the Indemnified  Party  reasonably may be deemed to
conflict with the interests of the  Indemnifying  Party,  the Indemnified  Party
shall have the right to select one  separate  counsel  and to assume  such legal
defenses and otherwise to  participate  in the defense of such action,  with the
reasonable expenses and fees of such separate counsel and other expenses related
to such participation to be reimbursed by the Indemnifying Party as incurred.

         (d) In order to  provide  for just and  equitable  contribution  in the
event of joint  liability  under the  Securities Act in any case in which either
(i) the  Purchaser,  or any  officer,  director  or  controlling  person  of the
Purchaser,  makes a claim for indemnification  pursuant to this Section 5 but it
is judicially  determined (by the entry of a final judgment or decree by a court
of competent  jurisdiction and the expiration of time to appeal or the denial of
the last right of appeal) that such  indemnification may not be enforced in such
case  notwithstanding  the fact that this Section 5 provides for indemnification
in such case, or (ii)  contribution  under the Securities Act may be required on
the part of the Purchaser or such officer, director or controlling person of



                                       6


the Purchaser in circumstances for which  indemnification is provided under this
Section 5; then,  and in each such case,  the  Company  and the  Purchaser  will
contribute to the aggregate losses, claims, damages or liabilities to which they
may be subject (after  contribution  from others) in such proportion so that the
Purchaser is responsible only for the portion represented by the percentage that
the  public  offering  price  of its  securities  offered  by  the  Registration
Statement bears to the public  offering price of all securities  offered by such
Registration  Statement,  provided,  however,  that,  in any such case,  (A) the
Purchaser  will not be required to contribute any amount in excess of the public
offering  price  of  all  such  securities   offered  by  it  pursuant  to  such
Registration  Statement;  and (B) no  person  or  entity  guilty  of  fraudulent
misrepresentation  (within  the  meaning  of  Section  10(f) of the Act) will be
entitled  to  contribution  from any person or entity who was not guilty of such
fraudulent misrepresentation.

     6.  REPRESENTATIONS AND WARRANTIES.

         (a) The Common Stock of the Company is  registered  pursuant to Section
12(b) or 12(g) of the Exchange Act and,  except with respect to certain  matters
which the  Company  has  disclosed  to the  Purchaser  on  Schedule  4.21 to the
Securities  Purchase   Agreement,   the  Company  has  timely  filed  all  proxy
statements,  reports,  schedules, forms, statements and other documents required
to be filed by it under the  Exchange  Act. The Company has filed (i) its Annual
Report on Form 10-K for the fiscal  year ended  December  31,  2002 and (ii) its
Quarterly  Report on Form 10-Q for the fiscal  quarters ended March 31, 2003 and
June 30, 2003  (collectively,  the "SEC  Reports").  Each SEC Report was, at the
time of its filing,  in  substantial  compliance  with the  requirements  of its
respective form and none of the SEC Reports,  nor the financial  statements (and
the notes thereto)  included in the SEC Reports,  as of their respective  filing
dates,  contained any untrue  statement of a material fact or omitted to state a
material fact required to be stated  therein or necessary to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The financial statements of the Company included in the SEC Reports
comply  as  to  form  in  all  material  respects  with  applicable   accounting
requirements  and the published rules and regulations of the Commission or other
applicable rules and regulations with respect thereto. Such financial statements
have been prepared in accordance with generally accepted  accounting  principles
("GAAP")  applied on a consistent  basis during the periods involved (except (i)
as may be otherwise indicated in such financial  statements or the notes thereto
or (ii) in the case of unaudited interim statements,  to the extent they may not
include  footnotes  or may be  condensed)  and fairly  present  in all  material
respects the financial  condition,  the results of operations and the cash flows
of the Company and its  subsidiaries,  on a consolidated  basis, as of, and for,
the periods presented in each such SEC Report.

         (b) The  Common  Stock is listed for  trading on the NASD OTC  Bulletin
Board and satisfies all requirements  for the continuation of such listing.  The
Company has not received any notice that its Common Stock will be delisted  from
the  NASD  OTC  Bulletin  Board  or that  the  Common  Stock  does  not meet all
requirements for the continuation of such listing.

         (c)  Neither the  Company,  nor any of its  affiliates,  nor any person
acting on its or their  behalf,  has directly or  indirectly  made any offers or
sales  of any  security  or  solicited  any  offers  to buy any  security  under
circumstances  that would cause the offering of the  Securities  pursuant to the
Securities  Purchase  Agreement  to be  integrated  with prior  offerings by the




                                       7


Company for purposes of the  Securities Act which would prevent the Company from
selling the Common Stock pursuant to Rule 506 under the  Securities  Act, or any
applicable  exchange-related  stockholder  approval  provisions,  nor  will  the
Company or any of its affiliates or  subsidiaries  take any action or steps that
would cause the offering of the Securities to be integrated with other offerings
(other than such concurrent offering to the Purchaser).

         (d) The  Warrants,  the Note and the shares of Common  Stock  which the
Purchaser may acquire  pursuant to the Warrants and the Note are all  restricted
securities  under  the  Securities  Act as of the  date of this  Agreement.  The
Company will not issue any stop transfer  order or other order impeding the sale
and  delivery  of any  of the  Registrable  Securities  at  such  time  as  such
Registrable  Securities  are  registered  for public sale or an  exemption  from
registration  is  available,  except as required by federal or state  securities
laws.

         (e) The Company  understands the nature of the  Registrable  Securities
issuable  upon the  conversion  of the Note and the  exercise of the Warrant and
recognizes that the issuance of such Registrable Securities may have a potential
dilutive effect.  The Company  specifically  acknowledges that its obligation to
issue the  Registrable  Securities  is binding upon the Company and  enforceable
regardless of the dilution such issuance may have on the ownership  interests of
other shareholders of the Company.

         (f) Except for  agreements  made in the  ordinary  course of  business,
there is no agreement  that has not been filed with the Commission as an exhibit
to a  registration  statement  or to a form  required to be filed by the Company
under the Exchange Act, the breach of which could reasonably be expected to have
a material  and adverse  effect on the Company  and its  subsidiaries,  or would
prohibit or  otherwise  interfere  with the ability of the Company to enter into
and perform any of its obligations under this Agreement in any material respect.

         (g) The  Company  will at all times  have  authorized  and  reserved  a
sufficient  number of shares of Common Stock for the full conversion of the Note
and exercise of the Warrants.

     7.  MISCELLANEOUS.

         (a)  REMEDIES.  In the event of a breach by the Company or by a Holder,
of any of their respective obligations under this Agreement,  each Holder or the
Company,  as the case may be, in  addition to being  entitled  to  exercise  all
rights granted by law and under this Agreement,  including  recovery of damages,
will be entitled to specific performance of its rights under this Agreement.

         (b) NO  PIGGYBACK  ON  REGISTRATIONS.  Except  as  and  to  the  extent
specified in Schedule  7(b) hereto,  neither the Company nor any of its security
holders  (other than the Holders in such capacity  pursuant  hereto) may include
securities  of  the  Company  in  any  Registration  Statement  other  than  the
Registrable  Securities,  and the Company  shall not after the date hereof enter
into any  agreement  providing  any such  right for  inclusion  of shares in the
Registration  Statement  to any of its  security  holders.  Except as and to the
extent specified in Schedule 7(b) hereto, the Company has not previously entered
into any agreement  granting any registration  rights with respect to any of its
securities to any Person that have not been fully satisfied.



                                       8


         (c)  COMPLIANCE.  Each Holder  covenants and agrees that it will comply
with the prospectus delivery requirements of the Securities Act as applicable to
it  in  connection  with  sales  of  Registrable   Securities  pursuant  to  the
Registration Statement.

         (d) DISCONTINUED DISPOSITION.  Each Holder agrees by its acquisition of
such  Registrable  Securities that, upon receipt of a notice from the Company of
the occurrence of a Discontinuation  Event (as defined below),  such Holder will
forthwith  discontinue  disposition  of such  Registrable  Securities  under the
applicable  Registration  Statement until such Holder's receipt of the copies of
the supplemented Prospectus and/or amended Registration Statement or until it is
advised in writing (the  "Advice") by the Company that the use of the applicable
Prospectus  may be resumed,  and, in either  case,  has  received  copies of any
additional  or  supplemental  filings  that are  incorporated  or  deemed  to be
incorporated  by reference in such  Prospectus or  Registration  Statement.  The
Company may provide  appropriate  stop orders to enforce the  provisions of this
paragraph.  For purposes of this Section 7(d), a  "Discontinuation  Event" shall
mean (i) when the  Commission  notifies  the  Company  whether  there  will be a
"review" of such Registration  Statement and whenever the Commission comments in
writing on such  Registration  Statement  (the  Company  shall  provide true and
complete  copies  thereof  and  all  written  responses  thereto  to each of the
Holders);  (ii) any  request  by the  Commission  or any other  Federal or state
governmental  authority  for  amendments  or  supplements  to such  Registration
Statement or Prospectus or for additional information; (iii) the issuance by the
Commission of any stop order suspending the  effectiveness of such  Registration
Statement covering any or all of the Registrable Securities or the initiation of
any  Proceedings  for that  purpose;  (iv) the  receipt  by the  Company  of any
notification  with respect to the suspension of the  qualification  or exemption
from  qualification  of  any of  the  Registrable  Securities  for  sale  in any
jurisdiction,  or the  initiation  or  threatening  of any  Proceeding  for such
purpose;  and/or (v) the  occurrence  of any event or passage of time that makes
the financial statements included in such Registration  Statement ineligible for
inclusion  therein  or any  statement  made in such  Registration  Statement  or
Prospectus or any document  incorporated or deemed to be incorporated therein by
reference  untrue in any material respect or that requires any revisions to such
Registration  Statement,  Prospectus or other  documents so that, in the case of
such  Registration  Statement  or  Prospectus,  as the case may be,  it will not
contain any untrue  statement  of a material  fact or omit to state any material
fact required to be stated therein or necessary to make the statements  therein,
in light of the circumstances under which they were made, not misleading.

         (e) PIGGY-BACK  REGISTRATIONS.  If at any time during the Effectiveness
Period  there is not an  effective  Registration  Statement  covering all of the
Registrable  Securities and the Company shall determine to prepare and file with
the  Commission  a  registration  statement  relating to an offering for its own
account or the account of others under the  Securities  Act of any of its equity
securities,  other than on Form S-4 or Form S-8 (each as  promulgated  under the
Securities Act) or their then  equivalents  relating to equity  securities to be
issued solely in connection  with any  acquisition  of any entity or business or
equity  securities  issuable in connection  with stock option or other  employee
benefit plans, then the Company shall send to each Holder written notice of such
determination and, if within fifteen days after receipt of such notice, any such
Holder  shall  so  request  in  writing,  the  Company  shall  include  in  such
registration  statement  all or any  part of such  Registrable  Securities  such
holder  requests  to be  registered  to the extent the Company may do so without
violating  registration  rights  of  others



                                       9


which exist as of the date of this Agreement,  subject to customary  underwriter
cutbacks  applicable  to all  holders  of  registration  rights  and  subject to
obtaining  any  required  the  consent  of any  selling  stockholder(s)  to such
inclusion under such registration statement.

         (f) AMENDMENTS AND WAIVERS. The provisions of this Agreement, including
the provisions of this sentence,  may not be amended,  modified or supplemented,
and waivers or  consents to  departures  from the  provisions  hereof may not be
given,  unless the same shall be in writing  and signed by the  Company  and the
Holders of the then  outstanding  Registrable  Securities.  Notwithstanding  the
foregoing, a waiver or consent to depart from the provisions hereof with respect
to a matter that relates  exclusively to the rights of certain  Holders and that
does not directly or indirectly  affect the rights of other Holders may be given
by Holders of at least a majority of the  Registrable  Securities  to which such
waiver or  consent  relates;  provided,  however,  that the  provisions  of this
sentence may not be amended, modified, or supplemented except in accordance with
the provisions of the immediately preceding sentence.

         (g)  NOTICES.  Any  notice  or  request  hereunder  may be given to the
Company or the Purchaser at the  respective  addresses set forth below or as may
hereafter be specified in a notice  designated as a change of address under this
Section 7(g).  Any notice or request  hereunder  shall be given by registered or
certified  mail,  return receipt  requested,  hand  delivery,  overnight mail or
telecopy  (confirmed  by mail).  Notices and  requests  shall be, in the case of
those by hand delivery, deemed to have been given when delivered to any party to
whom it is addressed,  in the case of those by mail or overnight mail, deemed to
have been given three (3)  business  days after the date when  deposited  in the
mail or with the overnight  mail carrier,  and, in the case of a telecopy,  when
confirmed. The address for such notices and communications shall be as follows:

           If to the Company:        Ophthalmic Imaging Systems, Inc.
                                     221 Lathrop Way, Suite I
                                     Sacramento, CA 95815
                                     Attention:  Chief financial officer
                                     Facsimile: (916) 646-0207

           With a copy to:           Jenkens & Gilchrist Parker Chapin LLP
                                     405 Lexington Avenue
                                     New York, New York 10174
                                     Attention: Henry I . Rothman
                                     Facsimile: (212) 704-6288

           If to a  Purchaser:       To the address set
                                     forth under such  Purchaser  name on
                                     the signature pages hereto.


                                       10

           If to any other Person who is then the registered Holder:

                                     To the address of such Holder as it
                                     appears in the stock transfer books
                                     of the Company



or such other address as may be  designated  in writing  hereafter in accordance
with  this  Section  7(g) by such  Person.

         (h) SUCCESSORS AND ASSIGNS.  This Agreement  shall inure to the benefit
of and be  binding  upon the  successors  and  permitted  assigns of each of the
parties  and shall  inure to the  benefit of each  Holder.  The  Company may not
assign its rights or obligations  hereunder without the prior written consent of
each Holder.  Each Holder may assign their  respective  rights  hereunder in the
manner  and to the  Persons  as  permitted  under  the  Notes  and the  Security
Agreement with the prior written consent of the Company, which consent shall not
be unreasonably withheld.

         (i) EXECUTION AND  COUNTERPARTS.  This Agreement may be executed in any
number of counterparts,  each of which when so executed shall be deemed to be an
original  and, all of which taken  together  shall  constitute  one and the same
Agreement.   In  the  event  that  any   signature  is  delivered  by  facsimile
transmission,  such  signature  shall create a valid  binding  obligation of the
party  executing  (or on whose behalf such  signature is executed) the same with
the same  force and  effect as if such  facsimile  signature  were the  original
thereof.

         (j) GOVERNING LAW. All questions concerning the construction, validity,
enforcement  and  interpretation  of this  Agreement  shall be  governed  by and
construed and enforced in accordance  with the internal laws of the State of New
York,  without regard to the principles of conflicts of law thereof.  Each party
agrees that all  Proceedings  concerning the  interpretations,  enforcement  and
defense of the  transactions  contemplated  by this Agreement shall be commenced
exclusively  in the state and  federal  courts  sitting in the City of New York,
Borough  of  Manhattan.  Each party  hereto  hereby  irrevocably  submits to the
exclusive  jurisdiction  of the state and federal  courts sitting in the City of
New York,  Borough of Manhattan for the adjudication of any dispute hereunder or
in connection herewith or with any transaction  contemplated hereby or discussed
herein,  and  hereby  irrevocably  waives,  and  agrees  not  to  assert  in any
Proceeding,  any claim that it is not personally  subject to the jurisdiction of
any such court,  that such  Proceeding  is improper.  Each party  hereto  hereby
irrevocably  waives  personal  service of process and consents to process  being
served in any such  Proceeding  by  mailing a copy  thereof  via  registered  or
certified  mail or overnight  delivery (with evidence of delivery) to such party
at the address in effect for notices to it under this  Agreement and agrees that
such service shall constitute good and sufficient  service of process and notice
thereof.  Nothing contained herein shall be deemed to limit in any way any right
to serve  process in any manner  permitted  by law.  Each  party  hereto  hereby
irrevocably  waives,  to the fullest extent permitted by applicable law, any and
all right to trial by jury in any legal proceeding arising out of or relating to
this Agreement or the transactions  contemplated  hereby.  If either party shall
commence a Proceeding to enforce any provisions of a Transaction Document,  then
the prevailing  party in such Proceeding  shall be reimbursed by the other party
for its reasonable attorneys fees and other



                                       12


costs and expenses incurred with the investigation,  preparation and prosecution
of such Proceeding.

         (k) CUMULATIVE  REMEDIES.  The remedies  provided herein are cumulative
and not  exclusive of any remedies  provided by law.

         (l) SEVERABILITY.  If any term,  provision,  covenant or restriction of
this  Agreement  is held by a court of  competent  jurisdiction  to be  invalid,
illegal,  void  or  unenforceable,  the  remainder  of  the  terms,  provisions,
covenants  and  restrictions  set forth  herein  shall  remain in full force and
effect and shall in no way be affected, impaired or invalidated, and the parties
hereto  shall use their  reasonable  efforts to find and  employ an  alternative
means to achieve the same or substantially  the same result as that contemplated
by such term,  provision,  covenant or restriction.  It is hereby stipulated and
declared to be the  intention of the parties  that they would have  executed the
remaining terms, provisions, covenants and restrictions without including any of
such that may be hereafter declared invalid, illegal, void or unenforceable.

         (m) HEADINGS.  The headings in this  Agreement are for  convenience  of
reference only and shall not limit or otherwise affect the meaning hereof.

       [Balance of page intentionally left blank; signature page follows.]









                                       12


         IN WITNESS WHEREOF,  the parties have executed this Registration Rights
Agreement as of the date first written above.

                                     OPHTHALMIC IMAGING SYSTEMS, INC.

                                     By:___________________________________
                                     Name:_________________________________
                                     Title:__________________________________



                                     LAURUS MASTER FUND, LTD.

                                     By:___________________________________
                                     Name:_________________________________
                                     Title:__________________________________


                                     Address for Notices:

                                     825 Third Avenue, 14th Floor
                                     New York, New York 10022
                                     Attention:  David Grin
                                     Facsimile:  212-541-4434









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