SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

         Date of report (Date of earliest event reported): July 20, 2005

                           OPHTHALMIC IMAGING SYSTEMS
                           --------------------------
             (Exact Name of Registrant as Specified in its Charter)

CALIFORNIA                               1-11140                   94-3035367
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(State or Other Jurisdiction of   (Commission File Number)     (I.R.S. Employer
Incorporation)                                               Identification No.)


221 Lathrop Way, Suite I
Sacramento, California                                                     95815
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(Address of Principal Executive Offices)                              (Zip Code)


(Registrant's telephone number, including area code):   (916) 646-2020


                                 Not Applicable
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          (Former Name or Former Address, if Changed Since Last Report)



Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):


|_|   Written  communications  pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)

|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)

|_|   Pre-commencement  communications  pursuant  to  Rule  14d-2(b)  under  the
      Exchange Act (17 CFR 240.14d-2(b))

|_|   Pre-commencement  communications  pursuant  to  Rule  13e-4(c)  under  the
      Exchange Act (17 CFR 240.13e-4(c))




ITEM 1.01.     ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT

      On July 20, 2005, the  Registrant  replaced two existing  debentures  that
were issued by the Registrant in an aggregate amount of up to $1,900,000, with a
new debenture in an aggregate amount of up to $2,000,000.

      One of the  terminated  debentures  was issued in favor of United  Mizrahi
Bank Ltd. and the other  terminated  debenture was issued in favor of Bank Leumi
Le-Israel.  The purpose of both  debentures  was to guarantee  and/or  provide a
security  interest  for certain  debts and  liabilities  of  Medivision  Medical
Imaging, an Israeli corporation and the majority  shareholder of the Registrant.
In lieu of the terminated debentures,  the Registrant entered into a new Secured
Debenture (the  "Debenture")  in favor of United Mizrahi Bank Ltd., in an amount
of up to $2,000,000  (plus interest,  commissions  and all expenses).  Under the
terms of the  Debenture,  the  Registrant  guarantees  the payment of all of the
debts and liabilities of Medivision Medical Imaging Ltd. to United Mizrahi Bank.
The Debenture is secured by a first lien on all of the assets of the Registrant.

ITEM 2.03.  CREATION OF A DIRECT FINANCIAL  OBLIGATION OR AN OBLIGATION UNDER AN
OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT

         The  information  provided in Item 1.01 of this Report is  incorporated
herein by reference.

ITEM 5.02. DEPARTURE OF DIRECTORS OR PRINCIPAL OFFICERS;  ELECTION OF DIRECTORS;
APPOINTMENT OF PRINCIPAL OFFICERS.

         On July 20, 2005,  Professor Alon Harris resigned from the Registrant's
Board of  Directors  upon his  appointment  by the  Board  of  Directors  to the
positions of Chairman of the Steering  Committee of the Registrant's  Scientific
Advisory  Board  and  Scientific  Advisor  to the  Board  of  Directors.  To the
Registrant's  knowledge  there are no  disagreements  between Mr. Harris and the
Registrant.

         On the same date,  Merle Symes was  appointed to the Board of Directors
as an independent director.  Mr. Symes and his immediate family members have had
no direct or indirect  interest in any transaction with the Registrant or any of
its subsidiaries  required to be disclosed pursuant to Item 404(a) of Regulation
S-B promulgated under the Securities Exchange Act of 1934, as amended.

         Mr. Symes is the President and Founder of The Provenance  Group, LLC, a
firm  specializing  in  corporate   strategy  and  innovation,   entrepreneurial
ventures, M&A, and technology transfer, which he founded in 2002. Prior thereto,
from 1997 to 2002 he was Vice  President  External  Technology  and  Director of
Corporate Development in the Surgical Division at Bausch & Lomb, Inc.


                                      -2-


ITEM 7.01.        REGULATION FD DISCLOSURE.

      A copy of the press release dated July 22, 2005  announcing the changes to
the Board of Directors of the Registrant is attached hereto as Exhibit 99.1.

ITEM 9.01.        FINANCIAL STATEMENTS AND EXHIBITS.

(c)   Exhibits

      Exhibit Number    Description
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            99.1  Press Release of the Registrant dated July 22, 2005.

            99.2  Debenture  dated July 20,  2005  between  the  Registrant  and
                  United Mizrahi Bank Ltd.




                                   SIGNATURES

      Pursuant to the  requirements  of the Securities  Exchange Act of 1934, as
amended,  the  Registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.

Date:    July 25, 2005                        OPHTHALMIC IMAGING SYSTEMS


                                              By: /s/ Ariel Shenhar
                                                  ------------------------------
                                                  Name:  Ariel Shenhar
                                                  Title: Chief Financial Officer