RUBIN BAUM LEVIN CONSTANT & FRIEDMAN
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                                  [LETTERHEAD]



                                November 25, 1997




Palatin Technologies, Inc.
214 Carnegie Center, Suite 100
Princeton, New Jersey 08540


     We have  acted as  counsel  for  Palatin  Technologies,  Inc.,  a  Delaware
corporation  (the  "Company"),   in  connection  with  the  preparation  of  the
Registration Statement on Form SB-2 (the "Initial Registration Statement") filed
with the Securities and Exchange  Commission  (the  "Commission")  on August 13,
1997, Registration No. 333-33569, as amended by Pre-Effective Amendment No. 1 on
Form S-3 to the Initial Registration  Statement (the "Amendment") filed with the
Commission  on November  24, 1997 (the  Amendment  and the Initial  Registration
Statement are collectively referred to herein as the "Registration  Statement"),
under the Securities Act of 1933, as amended (the "Act"), for registration under
the Act of the following securities of the Company:

     1. Up to 2,777,739  shares of common  stock,  par value $.01 per share (the
"Common  Stock"),  issuable upon  conversion of 137,780  shares of the Company's
Series A Convertible  Preferred  Stock, par value $0.01 per share (the "Series A
Convertible Preferred Stock");

     2. Up to 277,770 shares of Common Stock issuable upon  conversion of 13,778
shares of Series A  Convertible  Preferred  Stock  issuable upon exercise of the
Company's  Preferred  Stock  Placement  Warrants   ("Preferred  Stock  Placement
Warrants")  issued to designees  of  Paramount  Capital,  Inc.  (the  "Placement
Agent") in connection  with the issuance of the Series A  Convertible  Preferred
Stock;




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Palatin Technologies, Inc.
November 25, 1997
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     3. Up to  3,055,509  additional  shares of Common  Stock  issuable  upon an
adjustment in the conversion price of the Series A Convertible Preferred Stock;

     4. Up to 69,122  shares of  Common  Stock  issuable  upon  exercise  of the
Company's  Class C Warrants  ("Class C Warrants")  issued in connection with the
merger of a  newly-formed  wholly-owned  subsidiary of the Company with and into
RhoMed Incorporated, a New Mexico corporation ("RhoMed"),  pursuant to which all
of the equity  securities  of RhoMed  were  exchanged  for  Common  Stock of the
Company (the "Merger");

     5. Up to 177,788  shares of Common  Stock  issuable  upon  exercise  of the
Company's Common Stock Placement  Warrants  ("Common Stock Placement  Warrants")
issued by RhoMed to designees of the Placement Agent;

     6. Up to 39,167  shares of  Common  Stock  issuable  upon  exercise  of the
Company's  Class  B  Warrants   ("Class  B  Warrants")   which  were  by  RhoMed
in connection with a private offering;

     7. Up to 1,953  shares  of  Common  Stock  issuable  upon  exercise  of the
Company's Class B Placement  Warrants ("Class B Placement  Warrants")  issued by
RhoMed to designees of the Placement Agent;

     8. Up to 138,241 shares of Common Stock issued or issuable upon exercise of
the Company's Class A Warrants  ("Class A Warrants"),  of which 55,296 shares of
Common Stock are outstanding as of the date hereof,  which were issued by RhoMed
in connection with a private offering;




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Palatin Technologies, Inc.
November 25, 1997
Page 3


     9. Up to 20,733  shares of  Common  Stock  issuable  upon  exercise  of the
Company's Class A Placement  Warrants ("Class A Placement  Warrants")  issued by
RhoMed to designees of the Placement Agent;

     10.  Up to 12,500  shares  of Common  Stock  issued  upon  exercise  of the
Company's  Financial Services Advisory Agreement Warrants  ("Advisory  Agreement
Warrants") issued to a designee of the Placement Agent; and

     11.  63,910  shares of Common Stock issued to the designee of the Company's
largest creditor to pay accrued interest as of April 30, 1997.

     As  counsel  to the  Company,  we have  examined  such  corporate  records,
documents, agreements and such matters of law as we have considered necessary or
appropriate for the purpose of this opinion. Upon the basis of such examination,
we advise you that in our opinion:

     1. Up to  2,777,739  shares of Common Stock  issuable  upon  conversion  of
currently  outstanding  shares of Series A Convertible  Preferred  Stock, if and
when paid for and issued  upon  conversion  of the Series A  Preferred  Stock in
accordance  with the terms  thereof,  will be  legally  issued,  fully  paid and
non-assessable.

     2. Up to 277,770  shares of Common Stock  issuable  upon  conversion of the
Series A  Convertible  Preferred  Stock after  exercise of the  Preferred  Stock
Placement  Warrants,  if and when paid for and  issued  upon  conversion  of the
Series A  Convertible  Preferred  Stock  and the  exercise  of  Preferred  Stock
Placement Warrants in accordance with the terms thereof, will be legally issued,
fully paid and non-assessable.




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Palatin Technologies, Inc.
November 25, 1997
Page 4


     3. Up to 3,055,509  shares of Common Stock issuable upon  adjustment in the
conversion  price of the Series A Convertible  Preferred Stock, if and when paid
for and issued upon  conversion of the Series A Convertible  Preferred  Stock in
accordance  with  the  terms  of  the  Series  A  Convertible   Preferred  Stock
Certificate   of   Designation,   will  be  legally   issued,   fully  paid  and
non-assessable.

     4. Up to 69,122  shares of Common Stock  issuable  upon exercise of Class C
Warrants, if and when paid for and issued upon conversion of Class C Warrants in
accordance  with the terms  thereof,  will be  legally  issued,  fully  paid and
non-assessable.

     5. Up to 177,788  shares of Common Stock  issuable  upon exercise of Common
Stock  Placement  Warrants,  if and when paid for and issued upon  conversion of
Common Stock Placement  Warrants in accordance  with the terms thereof,  will be
will be legally issued, fully paid and non- assessable.

     6. Up to 39,167  shares of Common Stock  issuable  upon exercise of Class B
Warrants, if and when paid for and issued upon conversion of Class B Warrants in
accordance  with the terms  thereof,  will be  legally  issued,  fully  paid and
non-assessable.

     7. Up to 1,953 shares of Common  Stock  issuable  upon  exercise of Class B
Placement  Warrants,  if and when paid for and issued upon conversion of Class B
Placement Warrants in accordance with the terms thereof, will be legally issued,
fully paid and non-assessable.





RUBIN BAUM LEVIN CONSTANT & FRIEDMAN
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Palatin Technologies, Inc.
November 25, 1997
Page 5




     8. Up to 138,241  shares of Common Stock  issuable upon exercise of Class A
Warrants (48,404 of such shares of Common Stock have been legally issued and are
fully paid and non-assessable),  if and when paid for and issued upon conversion
of Class A  Warrants  in  accordance  with the terms  thereof,  will be  legally
issued, fully paid and non-assessable.

     9. Up to 20,733  shares of Common Stock  issuable  upon exercise of Class A
Placement Warrants have been duly authorized for issuance,  if and when paid for
and issued upon conversion of Class A Placement  Warrants in accordance with the
terms thereof, will be legally issued, fully paid and non-assessable.

     10. Up to 12,500 shares of Common Stock  issuable upon exercise of Advisory
Agreement Warrants,  if and when paid for and issued upon conversion of Advisory
Agreement Warrants in accordance with the terms thereof, will be legally issued,
fully paid and non-assessable.

     11.  The  63,910  shares of Common  Stock  issued  to the  designee  of the
Company's  largest  creditor to pay accrued interest as of April 30, 1997, which
may be sold in accordance  with the  provisions of the  Registration  Statement,
have been legally issued and are fully paid and non-assessable.

     We are  members  of the Bar of the  State  of New  York,  and the  opinions
expressed herein are limited to questions arising under the laws of the State of
New York, the  General Corporation Law of the  State of Delaware and the Federal





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Palatin Technologies, Inc.
November 25, 1997
Page 6


laws of the United  States of America,  and we disclaim  any opinion  whatsoever
with respect to matters governed by the laws of any other jurisdiction.

     We consent to the filing of this opinion as an exhibit to the  Registration
Statement and to the references to this firm under the caption  "Legal  Matters"
in the Prospectus  which is a part of the Registration  Statement.  Reference is
made to the section of the Registration Statement entitled "Legal Matters" for a
description  of ownership of the Company's  securities  by certain  attorneys of
this firm.

                                    Very truly yours,


                                    RUBIN BAUM LEVIN CONSTANT & FRIEDMAN