UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K


                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

      Date of report (Date of earliest event reported): DECEMBER 13 , 2004

                               ENZO BIOCHEM, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    NEW YORK
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                 (State or Other Jurisdiction of Incorporation)

        001-09974                                        13-2866202
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(Commission File Number)                      (IRS Employer Identification No.)

         60 EXECUTIVE BOULEVARD
          FARMINGDALE, NEW YORK                           11735
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(Address of Principal Executive Offices)               (Zip Code)



                                 (631-755-5500)
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              (Registrant's Telephone Number, Including Area Code)


- --------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)

     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     |_| Written communications pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

     [ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_| Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

     |_| Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))



ITEM 2.02.  RESULTS OF OPERATIONS AND FINANCIAL CONDITION..

On December 13, 2004, the Registrant issued a press release announcing its
operating results for the quarter ended October 31, 2004. A copy of the press
release is furnished as Exhibit 99.1 to this Current Report.

The information in this Current Report and the exhibit attached hereto are being
"furnished" hereunder and shall not be deemed filed for purposes of Section 18
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), nor
shall they be deemed incorporated by reference into any filings made by the
Registrant with the Securities and Exchange Commission under the Exchange Act or
the Securities Act of 1933, as amended, except as shall be expressly set forth
by specific reference in such filings.

                                       2


                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.


                               ENZO BIOCHEM, INC.


Date:  December 13, 2004       By:   /s/ Barry Weiner
                                     -------------------------------------------
                                     Barry Weiner
                                     President and Chief Financial Officer



                                  EXHIBIT INDEX



Exhibit No.       Description

99.1              Press Release of Enzo Biochem, Inc., dated December 13, 2004.