FILED PURSUANT TO RULE 424(b)(3) AND (c) FILE NUMBER 333-94161 PROSPECTUS SUPPLEMENT NO. 2 DATED FEBRUARY 24, 2000 TO PROSPECTUS DATED JANUARY 26, 2000 INHALE THERAPEUTIC SYSTEMS, INC. $108,450,000 OF 6 3/4% CONVERTIBLE SUBORDINATED DEBENTURES DUE OCTOBER 13, 2006 AND 3,388,268 SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THE DEBENTURES This prospectus supplement supplements the prospectus dated January 26, 2000 of Inhale Therapeutic Systems, Inc. relating to the public offering and sale by selling security holders described below. This prospectus supplement contains information on ownership of principal amount of debentures beneficially owned and offered and shares of our common stock issuable upon conversion of the debentures. This prospectus supplement should be read in conjunction with the prospectus, and this prospectus supplement is qualified by reference to the prospectus, except to the extent that the information provided by this prospectus supplement supersedes the information contained in the prospectus. SELLING SECURITY HOLDERS The table on pages 57, 58, 59 and 60 of the prospectus setting forth information concerning the selling security holders is amended by the addition of the following information to that table: PRINCIPAL AMOUNT OF COMMON STOCK COMMON STOCK DEBENTURES ISSUABLE UPON OWNED AFTER BENEFICIALLY OWNED CONVERSION OF THE COMMON STOCK COMPLETION OF THE SELLING SECURITY HOLDER AND OFFERED (1) DEBENTURES OFFERED OFFERING AIG SoundShore Strategic Holding Fund Ltd. (2).................... $ 2,160,000 67,484.18 67,484.18 -- AIG SoundShore Opportunity Holding Fund Ltd. (2).................... $ 698,000 21,807.39 21,807.39 -- AIG SoundShore Holdings Ltd. (2)... $ 392,000 12,247.13 12,247.13 -- Ashford Capital Management, f/b/o Anvil Investment Associates LP... $ 1,000,000 31,242.68 31,242.68 -- Bank of America Pension Plan....... $ 2,000,000 62,485.35 62,485.35 -- Fidelity Financial Trust: Fidelity Convertible Securities Fund $ 1,000,000 31,242.68 31,242.68 -- (1) Amounts indicated may be in excess of the total amount registered due to sales or transfers exempt from the registration requirements of the Securities Act since the date upon which the selling holders provided to us in the information regarding their debentures. (2) Amounts listed are in addition to the principal amount of debentures beneficially owned and offered by selling holder already included in the prospectus. Information concerning the selling holders may change from time to time and any changed information will be set forth in supplements to this prospectus if and when necessary. In addition, the conversion rate and therefore, the number of shares of common stock issuable upon conversion of the debentures, is subject to adjustment under certain circumstances. Accordingly, the aggregate principal amount of debentures and the umber of shares of common stock into which the debentures are convertible may increase or decrease.