SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D. C. 20549


                                    FORM 8-K

                 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED):
                                  MARCH 2, 2000

                               GENZYME CORPORATION
             (Exact name of registrant as specified in its charter)



          MASSACHUSETTS                       0-14680                       06-1047163
                                                             
 (State or other jurisdiction of      (Commission file number)     (IRS employer identification
  incorporation or organization)                                              number)


               ONE KENDALL SQUARE, CAMBRIDGE, MASSACHUSETTS 02139
               (Address of Principal Executive Offices) (Zip Code)

               Registrant's telephone number, including area code:
                                 (617) 252-7500





ITEM 5.  OTHER EVENTS.

         On March 2, 2000, the Board of Directors of Genzyme Corporation
("Genzyme") authorized, subject to the approval of Genzyme's stockholders, an
amendment to Genzyme's Articles of Organization (its "charter") that would
modify the terms of its Genzyme Molecular Oncology Division Common Stock, $0.01
par value per share (the "GZMO Stock"), Genzyme Surgical Products Division
Common Stock, $0.01 par value per share (the "GZSP Stock") and Genzyme Tissue
Repair Common Stock, $0.01 par value per share (the "GZTR Stock"). The general
purpose of the amendment is to update the terms of Genzyme's tracking stock so
that they include the types of rights and other terms contained in the more
recently introduced tracking stocks of other companies. The principal issues
addressed by the amendment are

     -    modifying the provisions that govern mandatory distributions to
          division stockholders upon a sale of all or substantially all of a
          division's assets, such that stockholders will receive a distribution
          more accurately reflecting the value assigned to those assets by a
          third party purchaser;

     -    permitting Genzyme to modify the terms of its tracking stock or to
          unwind its tracking stock structure without incurring the substantial
          costs and dilutive effects of exchanging its tracking stock at 30%, or
          some other, premium to its fair market value if, on the advice of tax
          counsel, the Board of Directors deems it desirable to take such action
          to avoid adverse tax consequences to Genzyme or its stockholders due
          to a change in tax laws affecting tracking stock; and

     -    describing in more detail the information that must be contained in
          notices sent to stockholders regarding any exchange of or distribution
          on their common stock.

         The amendment proposal will be described in the proxy statement to be
sent to Genzyme stockholders in connection with its 2000 Annual Meeting of
Stockholders. Article IV of Genzyme's Articles of Organization as proposed to be
amended and restated is filed herewith as Exhibit 99.1 and is incorporated
herein by reference. The proposed amendment may be modified or abandoned by
Genzyme prior to stockholder approval. The proposed amendment will become
effective if approved by Genzyme's stockholders and filed with, and declared
effective by, the Secretary of the Commonwealth of Massachusetts.

         In addition, Genzyme currently intends to convene a special meeting of
Genzyme stockholders some time following the Annual Meeting. At the special
meeting, Genzyme will ask its stockholders to consider and adopt a further
amendment to Genzyme's charter. Specifically, it will ask stockholders to
approve a charter amendment contemplating the creation of a new series of common
stock (the "GZBX Stock") which will track a new division that Genzyme
anticipates calling Genzyme Biosurgery. Genzyme Biosurgery will combine the
assets and liabilities of Genzyme Surgical Products and Genzyme Tissue Repair
with those of Biomatrix, Inc., with whom Genzyme has signed a merger agreement
on March 6, 2000 (the "Merger Agreement"). Genzyme will also ask holders of the
GZSP Stock and GZTR Stock to approve the transfer of the assets and liabilities
of Genzyme Surgical Products and Genzyme Tissue Repair into Genzyme Biosurgery
and the conversion of their shares of GZSP Stock and GZTR Stock into shares of
GZBX Stock (the "Recapitalization"). The GZBX Stock is expected to have the same
terms, rights and preferences as those of the GZMO Stock, GZSP Stock and GZTR
Stock as proposed to be amended by the amendment described in this Form 8-K. For
a fuller description of the Merger Agreement and Recapitalization, see Genzyme's
Current Report on Form 8-K filed with the Securities and Exchange Commission on
March 15, 2000.


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ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

         (c)      EXHIBITS:



EXHIBIT
   NO.            DESCRIPTION
- -------           -----------
               
99.1              Article IV of the Articles of Organization of Genzyme Corporation as proposed to be
                  amended and restated.  Filed herewith.




                                    SIGNATURE

           Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                       GENZYME CORPORATION

Dated:  March 22, 2000                 By: /s/ Peter Wirth
                                           ------------------------------------
                                           Peter Wirth
                                           Executive Vice President and Chief
                                           Legal Officer



                                       3



                                  EXHIBIT INDEX



EXHIBIT
   NO.            DESCRIPTION
- -------           -----------
               
99.1              Article IV of the Articles of Organization of Genzyme Corporation as proposed to be amended
                  and restated. Filed herewith.