EXHIBIT 10.17 [LETTERHEAD] August 24, 1998 REVISION #2 ----------- Mr. Michael Ostrach Vice President - Corporate Development Kosan Biosciences, Inc. 1450 Rollins Road Burlingame, CA 94010 Dear Mr. Ostrach: Subject to all the terms and conditions hereof and receipt by us of all documents requested by us, in form and substance satisfactory to us and our counsel, we are prepared to enter into the following loan transaction (the "Loan"). BORROWER OR "YOU": Kosan Biosciences, Inc. LENDER OR "WE" OR "US": FINOVA Technology Finance, Inc. TERM OF LOANS: 48 consecutive months MAXIMUM LOAN AMOUNT: $2,000,000 in one or more advances (each an "Advance") to finance your purchase of certain laboratory, office and production equipment and tenant improvements acceptable to us (the "Equipment"), plus softcosts related thereto not to exceed 20% of the amount of each Advance. Not more than $773,116 in Advances may be made unless and until receipt by us of confirmation of a signed collaboration agreement (in form and substance acceptable to us) with Johnson & Johnson (or another entity acceptable to us) which will provide an aggregate of no less than $6,000,000 of projected revenue. The initial Advance of $484,116, plus $289,000 for a Varian NMR when delivered and accepted shall comprise the $773,116 total above referenced. COLLATERAL: The due payment and performance of all of your present and future obligations to us shall be secured by a first and only perfected security interest in and to all of the Equipment, together with all proceeds of, and accessions and additions to, substitutions for, and all replacements of, any of the foregoing, whether cash or non-cash, including, but not limited to, insurance proceeds (collectively, the "Collateral") COLLATERAL LOCATION: Burlingame, CA ANTICIPATED CLOSING DATES: August 1998 through June 30, 1999 CLOSING DATE: The date on which all conditions to the Loan for the Initial Advance and all future Advances are satisfied by you and the Loan proceeds are disbursed to you or to other persons at your 1 direction. The Initial Advance and all further Advances shall be evidenced by one or more promissory notes (each a "Note"). Each Advance shall not be less than $100,000 secured by delivered and accepted Equipment. No Closing Dates shall occur after June 30, 1999. MONTHLY LOAN PAYMENTS: Each Note shall be payable in 48 consecutive monthly payments of principal and interest each equal to 2.332% of the Advance, subject to adjustment, payable monthly in advance, and followed by one payment equal to 12.5% of the Advance. The first Monthly Loan Payment shall be payable on the Closing Date of each Advance. ADJUSTMENT TO MONTHLY LOAN PAYMENTS: If, on the second business day preceding the Closing Date for each Advance, the highest yield for four-year U.S. Treasury Notes as published in THE WALL STREET JOURNAL is greater than the yield on June 23, 1998, the first 48 Monthly Loan Payments shall be increased to reflect such change in yield. The yield as of June 23, 1998 was 5.56%. As of the Closing Date for each Advance, the Monthly Loan Payments shall be fixed for the entire term. INTERIM PAYMENTS: In addition to the Monthly Loan Payments, interim payments shall accrue for each day from each Closing Date until the twenty-ninth day of the same month (27th day of the month of each Advance in the case of February) unless the Advance is made on the thirtieth or thirty-first day of a month. If the Closing Date is the thirty-first day of a month, the interim payment shall accrue from the Closing Date until the twenty-ninth day of the next following month. If the Closing Date is the thirtieth day of a month, there shall be no interim payment. The interim payment for each day shall be 1/30 of the adjusted interest rate multiplied by the amount of the Advance and shall be payable on the Closing Date. DOCUMENTATION: All documentation shall be prepared and reviewed by us or our counsel and shall be in form and substance satisfactory to us and our counsel in our and our counsel's sole and absolute discretion, and shall include, without limitation, the Notes, a loan and security agreement, the Letter of Credit (if required), landlord and mortgagee's waivers and consents, assignments, insurance policies, UCC Financing Statements, and such other documents or other agreements and as we and our counsel deem appropriate (collectively, the "Loan Documents"). LETTER OF CREDIT, OTHER LOAN PROVISIONS AND COVENANTS: A. LOAN PROVISIONS. The Loan Documents shall include the usual provisions and covenants in our loan agreements, cross default and cross collateralization provisions to all your Loans, and such other or different provisions and covenants that are customarily included in agreements of this kind. 2 B. MINIMUM CASH REQUIREMENT; LETTER OF CREDIT. You shall at all times maintain a minimum of unrestricted cash or cash equivalents of at least $5,000,000 (the "Minimum Cash Requirement"). In the event you at any time fail to maintain the Minimum Cash Requirement, you shall open an Irrevocable Letter of Credit, in form and substance satisfactory to us, issued by a Bank satisfactory to us, in our favor as beneficiary (the "Letter of Credit") , or provide us as Collateral cash or cash equivalents, acceptable to us, in an amount equal to fifty (50%) percent of the then current outstanding principal balance of the Loan. The failure to provide the Letter of Credit or other Collateral shall be an event of default. At month twenty-four of the initial Loan, we will review your current financial condition and future outlook. Following the review, we may in our sole discretion, reduce or waive the Minimum Cash Requirement for the remainder of the term of the Loans. C. INSURANCE. The Loan Documents shall provide for you, at all times to procure and maintain, or cause to be procured and maintained, policies of insurance, in such form, of such type and with insurers satisfactory to us. D. FINANCIAL REPORTING. You shall deliver to us or cause to be delivered to us your quarterly financial statements within 45 days following the end of each respective fiscal quarter and annual financial statements for you within 90 days following the end of each respective fiscal year. All annual financial statements shall be prepared in accordance with GAAP and be audited by a reputable firm of certified public accountants acceptable to us, and shall be accompanied by a certificate executed by such certified public accountants to the effect that you have complied with all covenants contained in the Loan Documents and there are no events of default thereunder ("Compliance Certificate"). All quarterly financial statements may be internally prepared in accordance with GAAP, and accompanied by a Compliance Certificate executed by the respective chief financial officer. E. ADDITIONAL REPRESENTATIONS. It shall be a condition precedent to the closing of each Advance that no payment due us is past due, whether as a lessee, a borrower, a guarantor or in some other capacity; that the you are in compliance with the provisions of this Commitment; that all information requested by us and 3 all documentation then required by our counsel has been received by us, including resolutions of your Board of Directors authorizing the transactions contemplated by this Commitment; that you are not in default under any material contract to which you are a party or by which it or your property is bound; that there has not been any material adverse change or threatened material adverse change in your financial or other condition, business, operations, properties, assets or prospects since December 31, 1997 or from the written information that has been supplied to us by you or any manufacturer of the Equipment prior to the date of this Commitment; that there shall be no actual or threatened conflict with, or violation of, any regulatory statute, standard or rule relating to you, your present or future operations, or the Equipment, the violation of which would have a material adverse effect on your financial condition; and that we receive an opinion of your counsel satisfactory to us. All information supplied by you shall be correct in all material respects and shall not omit any statement necessary to make the information supplied not be misleading. There shall be no material breach of the representations and warranties by you in the Loan Documents. The representations shall include that the cost of each item of the Equipment does not exceed the fair and usual price for like quantity purchases of such item and reflects all discounts, rebates and allowances for the Equipment given to you or any of your affiliate by you by the manufacturer, supplier or anyone else including, without limitation, discounts for advertising, prompt payment, testing or other services. FEES AND EXPENSES: You shall be responsible for our reasonable fees and expenses in connection with the transaction, including UCC filing, due diligence search fees and the expenses of our counsel to respond to any requested modifications or changes to the Lender's standard documentation. We shall use our best efforts to notify you when the Fees and Expenses reach $1,500; however, our failure to do so is not intended to limit the fees and expenses set forth herein. COMMITMENT FEE: Simultaneously with the acceptance of this Commitment, you shall pay us a non-refundable Commitment Fee of $20,000. The $20,000 Application Fee, previously paid shall be applied towards the Commitment Fee. The Commitment Fee shall be first applied to the Fees and Expenses due hereunder. Any remainder shall be applied to the second Monthly Loan Payment due under each Advance on a pro-rata basis. In the event that we are unable to receive confirmation of a signed collaboration agreement (in form and substance acceptable to us) with Johnson & Johnson (or another entity acceptable to us) which will provide an aggregate of no less than 4 $6,000,000 of projected revenue, we will credit the unused portion of the Commitment Fee to your account within thirty days of your written request to us. SURVIVAL: This Commitment Letter shall survive the closing. However, if there is any conflict between the terms and conditions of the Loan Documents and those of this Commitment Letter, the Loan Documents shall control. This Commitment and the Closing of the transaction contemplated herein are subject, amongst other things, to receipt by us, in form and substance satisfactory to us and our counsel, at or prior to Closing, of: (i) all documentation and other requirements set forth herein including but not limited to the Loan Documents and other requirements set forth herein and as may be required by our counsel; and (ii) our receipt, in form and substance satisfactory to us, of all financial and credit information requested by us, (including, but not limited to, your audited financial statements for the year ended 1997), which reflects no material adverse change in your or condition, business, financial or otherwise; and (iii) evidence that the Equipment is owned by you, free and clear of all liens and encumbrances; and (iv) a completed year 2000 compliance form satisfactory to us; and (v) evidence of such insurance required by us, written by insurers and in amounts satisfactory to us; and (vi) such opinions of your counsel, certificates, waivers, releases, Uniform Commercial Code Financing Statements, due diligence searches, and further documents as may be required by us or our counsel. In addition to all other conditions and requirements set forth herein, this Commitment and the closing of the transaction contemplated hereunder shall be subject, in our sole judgment, that there be no material adverse change in your financial, business or other condition. This Commitment is not assignable without our prior written consent. We reserve the right to cancel this Commitment in the event you or any of your officers, employees, agents or representatives has made any misrepresentation to us or has withheld any information from us with regard to the transaction contemplated hereby. As used in this Commitment, the terms "satisfactory to us" or "acceptable to us" or "satisfactory to our counsel" or "acceptable to our counsel" or terms of similar import mean satisfactory or acceptable to us or our counsel in our or its sole judgment and discretion. This Commitment and the Loan Documents shall be governed by the laws of the State of Arizona. Any dispute arising under this Commitment shall be litigated by you only in any federal or state court located in the State of Arizona, or any state court located in Maricopa 5 County, Arizona; and you hereby irrevocably submit to the personal jurisdiction of such courts and waive any objection that may exist as to venue or convenience of such forums. Nothing contained herein shall preclude us from commencing any action in any court having jurisdiction thereof. In the event that the Initial Advance does not close prior to December 31, 1998 because of your failure to satisfy the conditions for the closing, or because of a material adverse change in your financial, business or other condition, this Commitment shall terminate and we shall have no liability to you and we shall retain, as earned, the Commitment Fee. In the event we fail to complete this transaction and such failure is not because of your inability to satisfy all the conditions for closing or a material adverse change in your financial, business or other condition, our liability shall be limited to a return of the Commitment Fee, less Fees and Expenses due hereunder. Please execute the copy of this letter acknowledging your acceptance of the terms hereof and return it to us. If a copy of this Commitment is not executed and returned by you by August 28, 1998, this offer shall be deemed withdrawn. This Commitment supersedes, replaces and terminates all previous proposals and/or agreements including, but not limited to, our proposal dated June 23, 1998 which shall be null and void. Should you have any questions, please call me. If you wish to accept this Commitment, please sign and return the enclosed duplicate letter to the undersigned by August 28, 1998. Sincerely, FINOVA TECHNOLOGY FINANCE, INC. By /s/ Linda A. Moschitto ----------------------------------------- Linda A. Moschitto Director - Contract Administration Accepted this 25 day of August, 1998 KOSAN BIOSCIENCES, INC. By: /s/ Michael Ostrach ----------------------------------------- Michael Ostrach Vice President - Corporate Development 6