TRANSGENOMIC, INC.

                              4,000,000 SHARES(1)

                                  COMMON STOCK


                             UNDERWRITING AGREEMENT

                                                                  _____ __, 2000


CHASE SECURITIES INC.
Bear, Stearns & Co. Inc.
Dain Rauscher Incorporated
  as representatives of the
  Several Underwriters
c/o Chase Securities Inc.
One Bush Street
San Francisco, CA  94104

Ladies and Gentlemen:

         Transgenomic, Inc. a Delaware corporation (herein called the
Company, which term shall also include its direct and indirect subsidiaries,
unless the context otherwise requires), proposes to issue and sell 4,000,000
shares of its authorized but unissued common stock, $0.01 par value (herein
called the Common Stock) (said 4,000,000 shares of Common Stock being herein
called the Underwritten Stock). The Company proposes to grant to the
Underwriters (as hereinafter defined) an option to purchase up to 600,000
additional shares of Common Stock (herein called the Option Stock and with
the Underwritten Stock herein collectively called the Stock). The Common
Stock is more fully described in the Registration Statement and the
Prospectus hereinafter mentioned.

         The Company hereby confirms the agreements made with respect to the
purchase of the Stock by the several underwriters, for whom you are acting,
named in SCHEDULE I hereto (herein collectively called the Underwriters,
which term shall also include any underwriter purchasing Stock pursuant to
Section 3(b) hereof). You represent and warrant that you have been authorized
by each of the other Underwriters to enter into this Agreement on its behalf
and to act for it in the manner herein provided.

         1. REGISTRATION STATEMENT. The Company has filed with the Securities
and Exchange Commission (herein called the Commission) a registration
statement on Form S-1 (No. 333-32174), including the related preliminary
prospectus, for the registration under the Securities Act of 1933, as amended
(herein called the Securities Act), of the Stock. Copies of such registration
statement and of each amendment thereto, if any, including the related
preliminary prospectus (meeting the requirements of Rule 430A of the rules
and regulations of the Commission) heretofore filed by the Company with the
Commission have been delivered to you.

- --------

(1) Plus an option to purchase from the Company up to additional shares to cover
over-allotments.



         The term Registration Statement as used in this agreement shall mean
such registration statement, including all exhibits and financial statements,
all information omitted therefrom in reliance upon Rule 430A and contained in
the Prospectus referred to below, in the form in which it became effective,
and any registration statement filed pursuant to Rule 462(b) of the rules and
regulations of the Commission under the Securities Act (herein called the
Rules and Regulations) with respect to the Stock (herein called a Rule 462(b)
registration statement), and, in the event of any amendment thereto after the
effective date of such registration statement (herein called the Effective
Date), shall also mean (from and after the effectiveness of such amendment)
such registration statement as so amended (including any Rule 462(b)
registration statement). The term Prospectus as used in this Agreement shall
mean the prospectus relating to the Stock first filed with the Commission
pursuant to Rule 424(b) and Rule 430A (or if no such filing is required, as
included in the Registration Statement) and, in the event of any supplement
or amendment to such prospectus after the Effective Date, shall also mean
(from and after the filing with the Commission of such supplement or the
effectiveness of such amendment) such prospectus as so supplemented or
amended. The term Preliminary Prospectus as used in this Agreement shall mean
each preliminary prospectus included in such registration statement prior to
the time it becomes effective.

         The Registration Statement has been declared effective under the
Securities Act, and no post-effective amendment to the Registration Statement
has been filed as of the date of this Agreement. No stop order suspending the
effectiveness of the Registration Statement is in effect, and no proceedings
for such purpose are pending before or threatened by the Commission. The
Company has caused to be delivered to you copies of each Preliminary
Prospectus and has consented to the use of such copies for the purposes
permitted by the Securities Act.

         2.       REPRESENTATIONS AND WARRANTIES OF THE COMPANY.

         The Company hereby represents and warrants as follows:

                  (a) Each of the Company and its subsidiaries has been duly
         incorporated and is validly existing as a corporation in good standing
         under the laws of the jurisdiction of its incorporation, has full
         corporate power and authority to own or lease its properties and
         conduct its business as described in the Registration Statement and the
         Prospectus and as being conducted, and is duly qualified as a foreign
         corporation and in good standing in all jurisdictions in which the
         character of the property owned or leased or the nature of the business
         transacted by it makes qualification necessary (except where the
         failure to be so qualified would not have a material adverse effect on
         the business, properties, financial condition or results of operations
         of the Company and its subsidiaries, taken as a whole) (herein called a
         Material Adverse Effect). The Company has no Subsidiary (as defined in
         the Rules and Regulations) other than Transgenomic, Ltd., a U.K.
         limited liability company, and Transgenomic St. Thomas, Inc., a
         corporation organized under the laws of the U.S. Virgin Islands (herein
         called the Subsidiaries). Other than the Subsidiaries, the Company does
         not own, directly or indirectly, any shares of capital stock or any
         other equity interest in any firm, partnership, joint venture,
         association or other entity.

                  (b) Since the respective dates as of which information is
         given in the Registration Statement and the Prospectus, other than as
         set forth in the Registration Statement and the Prospectus, (i) there
         has not been any material adverse change, or any development involving
         a prospective material adverse change, in the business,

                                       2


         properties, financial condition or results of operations of the Company
         and its Subsidiaries, taken as a whole, whether or not arising from
         transactions in the ordinary course of business, (ii) neither the
         Company nor any of its Subsidiaries has incurred any material liability
         or obligation, direct or contingent, and (iii) since such dates, except
         in the ordinary course of business, neither the Company nor any of its
         Subsidiaries has entered into any material transaction not referred to
         in the Registration Statement and the Prospectus. Neither the Company
         nor any of its Subsidiaries has any material contingent obligations
         which are not disclosed in the Prospectus or provided for in the
         Company's consolidated financial statements that are included in the
         Registration Statement.

                  (c) The Registration Statement and the Prospectus comply, and
         on the Closing Date (as hereinafter defined) and any later date on
         which Option Stock is to be purchased, the Prospectus will comply, in
         all material respects, with the provisions of the Securities Act and
         the Rules and Regulations; on the Effective Date, the Registration
         Statement did not contain any untrue statement of a material fact and
         did not omit to state any material fact required to be stated therein
         or necessary in order to make the statements therein not misleading;
         and, on the Effective Date the Prospectus did not and, on the Closing
         Date and any later date on which Option Stock is to be purchased, will
         not contain any untrue statement of a material fact or omit to state
         any material fact necessary in order to make the statements therein, in
         the light of the circumstances under which they were made, not
         misleading; PROVIDED, HOWEVER, that none of the representations and
         warranties in this subparagraph (c) shall apply to statements in, or
         omissions from, the Registration Statement or the Prospectus made in
         reliance upon and in conformity with information herein or otherwise
         furnished in writing to the Company by or on behalf of the Underwriters
         for use in the Registration Statement or the Prospectus.

                  (d) The shares of the Company's common stock, $.01 par value,
         issued and outstanding prior to the offering of the Stock have been
         duly authorized and are validly issued, fully paid and nonassessable.
         The Stock, when issued and sold to the Underwriters as provided herein,
         will be duly authorized and, when issued and paid for as contemplated
         herein, will be validly issued, fully paid and nonassessable and
         conform to the description thereof in the Prospectus. No preemptive
         right, registration right, right of first refusal or other similar
         rights of stockholders exists with respect to any Stock or the issue or
         sale thereof, except as set forth in the Prospectus. No further
         approval or authority of the stockholders or the Board of Directors of
         the Company will be required for the issuance and sale of the Stock as
         contemplated herein. Except as described in the Prospectus, neither the
         filing of the Registration Statement nor the offering or sale of the
         Stock as contemplated by this Agreement gives rise to any rights, other
         than those which have been waived or satisfied, for or relating to the
         registration of any shares of capital stock. Except as described in the
         Prospectus, there are no contracts, agreements or understandings
         between the Company and any person granting such person the right to
         require the Company to file a registration statement under the
         Securities Act with respect to any securities of the Company owned or
         to be owned by such person or to require the Company to include such
         securities in the securities registered pursuant to the Registration
         Statement or in any securities being registered pursuant to any other
         registration statement filed by the Company under the Securities Act.
         Except as described in the Prospectus, there are no outstanding
         subscriptions, rights, warrants, options, calls, convertible
         securities, commitments of sales or liens

                                       3


         related to or entitling any person to purchase or otherwise acquire
         any shares of the capital stock of, or other ownership interest in
         the Company.

                  (e) Prior to the Closing Date, the Stock to be issued and sold
         by the Company will be authorized for listing by the Nasdaq National
         Market upon official notice of issuance.

                  (f) The Commission has not issued any order preventing or
         suspending the use of any Preliminary Prospectus or Prospectus relating
         to the proposed offering of Stock, nor, to the best knowledge of the
         Company, instituted proceedings for that purpose.

                  (g) Each Preliminary Prospectus or Prospectus filed as part of
         the Registration Statement as originally filed or as part of any
         amendment thereto, or filed pursuant to Rule 424 under the Securities
         Act, complied when so filed in all material respects with the
         Securities Act, and did not contain an untrue statement of a material
         fact or omit to state a material fact necessary in order to make the
         statements therein, in the light of the circumstances under which they
         were made, not misleading; PROVIDED, HOWEVER, that none of the
         representations and warranties contained in this subparagraph (g) shall
         apply to the statements in, or omissions from, any Preliminary
         Prospectus made in reliance upon and in conformity with information
         herein or otherwise furnished in writing to the Company by or on behalf
         of the Underwriters for use in such Preliminary Prospectus.

                  (h) The authorized and outstanding capital stock of the
         Company is as set forth in the Prospectus under the caption
         "Capitalization". The form of certificates for the Stock conforms to
         the legal requirements of the state of Delaware, the Company's charter
         and bylaws and the rules of the Nasdaq National Market.

                  (i) The Commission has not issued an order preventing or
         suspending the use of any Prospectus relating to the proposed offering
         of the Stock, nor, to the best knowledge of the Company, instituted
         proceedings for that purpose.

                  (j) The financial statements of the Company, together with
         related notes and schedules as set forth in the Registration Statement,
         present fairly the consolidated financial position and the results of
         operations and cash flows of the Company and its Subsidiaries at the
         indicated dates and for the indicated periods. Such financial
         statements and related schedules have been prepared in accordance with
         generally accepted accounting principles, consistently applied
         throughout the periods involved, and all adjustments necessary for a
         fair presentation of results for such periods have been made. The
         summary and selected financial data included in the Registration
         Statement present fairly the information shown therein and such data
         has been compiled on a basis consistent with the financial statements
         presented therein and the books and records of the Company. The other
         financial and statistical information and data set forth in the
         Registration Statement are, in all material respects, accurately
         presented and prepared on a basis consistent with such financial
         statements and the books and records of the Company.

                  (k) Deloitte & Touche LLP, who have certified certain of the
         financial statements filed with the Commission as part of the
         Registration Statement, are

                                       4


         independent public accountants as required by the Securities Act and
         the Rules and Regulations.

                  (l) Except as disclosed in the Registration Statement, there
         is no action, suit, claim or proceeding pending, or, to the knowledge
         of the Company, threatened against the Company, any of its
         Subsidiaries, or any of their respective directors, officers or
         properties, before any court or administrative agency or otherwise,
         which if determined adversely to the Company or such Subsidiaries could
         reasonably be expected to result in any Material Adverse Effect or
         prevent the consummation of the transactions contemplated hereby.

                  (m) There are no agreements, contracts, leases or documents of
         the Company of a character required to be described or referred to in
         the Registration Statement or Prospectus or to be filed as an exhibit
         to the Registration Statement by the Securities Act or the Rules and
         Regulations which have not been accurately described in all material
         respects or referred to in the Registration Statement or Prospectus or
         filed as exhibits to the Registration Statement. The agreements,
         contracts, leases or documents so described in the Registration
         Statement and Prospectus are in full force and effect on the date
         hereof (unless otherwise indicated in the Registration Statement and
         the Prospectus), and neither the Company nor, to the best of the
         Company's knowledge, any other party, is in breach of or default under,
         and no event has occurred which with the giving of notice or with the
         lapse of time would constitute a breach of or default under, any of
         such agreements, contracts, leases or documents. Neither the Company,
         nor to its knowledge, any other party has repudiated any provision of
         such agreements, contracts, leases or documents.

                  (n) Each of the Company and its Subsidiaries has good and
         marketable title to all of the properties and assets as described in
         the Registration Statement or as reflected in the financial statements
         filed with the Commission as part of the Registration Statement, free
         and clear of any lien, mortgage, pledge, charge or encumbrance of any
         kind except those reflected in such financial statements or as
         described in the Registration Statement. All leases to which the
         Company or any of its Subsidiaries is a party are valid and binding
         obligations of the Company or such Subsidiary, as the case may be, and
         no default by the Company or such Subsidiary has occurred or is
         continuing thereunder which could reasonably be expected to result in a
         Material Adverse Effect, and each of the Company and its Subsidiaries
         enjoys peaceful and undisturbed possession under all such leases to
         which it is a party as lessee. Such leases conform in all material
         respects to the descriptions thereof set forth in the Prospectus.

                  (o) Each of the Company and its Subsidiaries has timely filed
         all federal, state, local and foreign income tax returns which have
         been required to be filed and have paid all taxes indicated by said
         returns and all assessments received by them or any of them to the
         extent that such taxes have become due and are not being contested in
         good faith except where the failure to file such returns and pay such
         taxes would not have a Material Adverse Effect. All tax liabilities
         (including those being contested in good faith) for the periods covered
         by the financial statements of the Company that are included in the
         Registration Statement have been adequately provided for in such
         financial statements. No tax deficiency has been, or to the best of the
         Company's knowledge, might be, asserted or contemplated against the
         Company or any of its Subsidiaries.

                                       5


                  (p) The Company has full legal right, power and authority to
         enter into this Agreement and to perform the transactions contemplated
         hereby. This Agreement has been duly authorized, executed and delivered
         by the Company and (assuming due authorization and delivery by the
         Underwriters) is a valid and binding agreement of the Company,
         enforceable in accordance with its terms except insofar as
         indemnification and contribution provisions may be limited by Federal
         or state securities laws, principles of public policy or equitable
         principles and except as enforceability may be limited by bankruptcy,
         insolvency, reorganization, moratorium or similar laws relating to or
         affecting creditors' rights generally or by general equitable
         principles.

                  (q) Neither the Company nor any of its Subsidiaries is, or
         with the giving of notice or lapse of time or both will be, in
         violation of or in default under its charter or bylaws or under any
         agreement, lease, contract, indenture or other instrument or obligation
         to which it is a party or by which it, or any of its properties, is
         bound and which default could have a Material Adverse Effect. The
         execution and delivery of this Agreement by the Company and the
         consummation of the transactions herein contemplated and the
         fulfillment of the terms hereof will not conflict with or result in a
         breach of any of the terms or provisions of, or constitute a default
         under, any indenture, mortgage, deed of trust or other agreement or
         instrument to which the Company is a party, or of the respective
         Certificate of Incorporation or Bylaws of the Company or any law,
         order, rule or regulation, injunction, judgment, or decree applicable
         to the Company or any of its Subsidiaries of any court or of any
         regulatory body or administrative agency or other governmental body
         having jurisdiction over the Company or any of its Subsidiaries, which
         conflict, breach or default could have a Material Adverse Effect.

                  (r) Each approval, consent, order, authorization, designation,
         declaration or filing by or with any regulatory, administrative or
         other governmental body necessary in connection with the execution and
         delivery by the Company of this Agreement and the consummation of the
         transactions herein contemplated, including, without limitation, any
         such approval, consent, order, authorization, designation, declaration
         or filing which may be required in connection with the offering of
         Stock reserved for sale to the Company's directors, officers,
         employees, business associates and related persons (herein called
         the Directed Shares) pursuant to a program established for such
         purpose by the Company (herein called the Directed Share Program)
         (except as may be required in connection with the registration of
         the Stock under the Securities Act and such additional steps as may
         be required by the National Association of Securities Dealers, Inc.
         (herein called the NASD) or such additional steps as may be necessary
         to qualify the Stock for public offering by the Underwriters under
         state securities or blue sky laws) has been obtained or made and is
         in full force and effect.

                  (s) The Company and each of its Subsidiaries now holds and at
         the Closing Date and any later date on which the Option Stock is
         purchased, as the case may be, will hold, all licenses, consents,
         certificates, orders, approvals and permits from all state, United
         States, foreign and other governmental or regulatory authorities, that
         are required for the conduct of the business of the Company and its
         Subsidiaries as such business is currently conducted and as proposed to
         be conducted as described in the Prospectus, except for such licenses,
         certificates approvals and permits the failure of which to maintain
         would not have a Material Adverse Effect, all of which are valid and in
         full force and effect (and there is no proceeding pending or, to the
         best knowledge of the Company, threatened which may cause any such
         license, consent, certificate, order,

                                       6


         approval or permit to be withdrawn, cancelled, suspended or not
         renewed). Neither the Company nor any of its Subsidiaries is in
         violation or breach of any of its obligations under, or of the terms
         of, any such license, consent, certificate, order, approval or permit,
         except for such breach, default or failure as would not reasonably be
         expected to result in a Material Adverse Effect.

                  (t) The Company and each of its Subsidiaries is in compliance
         with all of the laws, rules, regulations, orders, directives or
         judgments issued or administered by any governmental agency or body or
         any court, foreign or domestic having jurisdiction over the Company or
         any of its Subsidiaries or any of their respective properties or
         assets, except where any such failure to be in compliance would not
         have a Material Adverse Effect.

                   (u) The Company and each of its Subsidiaries (i) is in
         compliance with any and all applicable foreign, federal, state and
         local laws and regulations relating to the protection of human health
         and safety, the environment or hazardous or toxic substances or wastes,
         pollutants or contaminants (including, without limitation, all laws and
         regulations relating to biohazardous substances) (herein called
         Environmental Laws), (ii) has received all permits, licenses or other
         approvals required of it under applicable Environmental Laws to conduct
         its respective business and (iii) is in compliance with all terms and
         conditions of any such permit, license or approvals, except where such
         noncompliance with Environmental Laws, failure to receive required
         permits, licenses or other approvals or failure to comply with the
         terms and conditions of such permits, licenses or approvals would not,
         singly, or in the aggregate, have a Material Adverse Effect.

                  (v) There are no costs or liabilities associated with
         Environmental Laws (including, without limitation, any capital or
         operating expenditures required for clean-up, closure of properties or
         compliance with Environmental Laws or any permit, license or approval,
         any related constraints on operating activities and any potential
         liabilities to third parties) which would, singly or in the aggregate,
         have a Material Adverse Effect.

                  (w) To the best of Company's knowledge, no labor disturbance
         by the employees of the Company or its Subsidiaries exists or is
         imminent, and the Company is not aware of any existing or imminent
         labor disturbance by the employees of any of its principal suppliers,
         authorized dealers or distributors that might be expected to result in
         a Material Adverse Effect. No collective bargaining agreement exists
         with any of the Company's or any of its Subsidiaries' employees and, to
         the best of the Company's knowledge, no such agreement is imminent.

                  (x) The Company is in compliance in all material respects with
         all currently applicable provisions of the Employee Retirement Income
         Security Act of 1974, as amended, including the regulations and
         published interpretations thereunder (herein called ERISA); no
         "reportable event" (as defined in ERISA) has occurred with respect to
         any "pension plan" (as defined in ERISA) for which the Company would
         have any liability; the Company has not incurred and does not expect to
         incur liability under (i) Title IV of ERISA with respect to termination
         of, or withdrawal from, any "pension plan" or (ii) Sections 412 or 4971
         of the Internal Revenue Code of 1986, as amended, including the
         regulations and published interpretation thereunder (herein called the
         Code); and each "pension plan" for which the Company would have any
         liability that is intended to be qualified under Section 401(a) of the
         Code is so qualified in all material

                                       7


         respects and nothing has occurred, whether by action or by failure to
         act, that would cause the loss of such qualification.

                  (y) The Company and each of its Subsidiaries owns or possesses
         adequate licenses or other rights to the patents and patent
         applications, copyrights, trademarks, service marks, trade names,
         technology and know-how (including trade secrets and other unpatented
         and/or unpatentable proprietary rights) (herein collectively called
         Intellectual Property) which are necessary to conduct, or currently
         employed by them in connection with the conduct, of their businesses as
         described in the Registration Statement and the Prospectus. Neither the
         Company nor any of its Subsidiaries is obligated to pay a material
         royalty, grant a material license or provide other material
         consideration to any third party in connection with the Intellectual
         Property, except as described in the Registration Statement and in the
         Prospectus. Except as set forth in the Registration Statement and the
         Prospectus, neither the Company nor any of its Subsidiaries has
         received any notice of, or has any knowledge of, any infringement of or
         conflict with any rights of the Company by others or any infringement
         of or conflict with any rights of others, in each case with respect to
         any Intellectual Property which, singly or in the aggregate, if the
         subject of an unfavorable decision, ruling or finding, would have a
         Material Adverse Effect. There are no legal or governmental proceedings
         pending or threatened relating to Intellectual Property, which, singly
         or in the aggregate, would have a Material Adverse Effect. To the
         Company's best knowledge, none of the Intellectual Property licensed to
         or by the Company or any of its Subsidiaries is unenforceable or
         invalid; and neither the Company nor any of its Subsidiaries is aware
         of the granting of any patent rights to third parties or the filing of
         any patent applications by third parties or of any other rights of
         third parties to, or conflicting with, any Intellectual Property owned
         by the Company or any of its Subsidiaries. Except as set forth in the
         Registration Statement and the Prospectus, no third party, including
         any academic or governmental organization, possesses rights to the
         Intellectual Property which, if exercised, could reasonably be expected
         to result in a Material Adverse Effect.

                  (z) To the best of the Company's knowledge, in connection with
         the filing of all patent applications filed or caused to be filed by
         the Company and its Subsidiaries with the United States Patent and
         Trademark Office (herein called the PTO), the Company and each of its
         Subsidiaries has complied with the PTO's duty of candor and disclosure
         for their patent and has made no misrepresentation in any such
         application or in any application filed with any applicable foreign and
         international patent authorities. The Company is unaware of any facts
         material to a determination of patentability regarding the Company's
         and its Subsidiaries' patent applications not called to the attention
         of the PTO and is unaware of any facts not called to the attention of
         the PTO which would preclude the grant of a patent for such
         applications. The Company has no knowledge of any facts which would
         materially conflict with the Company's or its Subsidiaries' ownership
         rights to the Company's patent applications.

                  (aa) The Company is not, and after giving effect to the offer
         and sale of the Stock and the application of the proceeds thereof as
         described in the Prospectus, will not be, an "investment company" or a
         company "controlled" by an "investment company" within the meaning of
         such terms under the Investment Company Act of 1940, as amended (herein
         called the Investment Company Act), and the rules and regulations
         thereunder.

                                       8


                  (bb) The Company and each of its Subsidiaries maintains a
         system of internal accounting controls sufficient to provide reasonable
         assurances that (i) transactions are executed in accordance with
         management's general or specific authorization; (ii) transactions are
         recorded as necessary to permit preparation of financial statements in
         conformity with generally accepted accounting principles and to
         maintain accountability for assets; (iii) access to assets is permitted
         only in accordance with management's general or specific authorization;
         and (iv) the recorded accountability for assets is compared with
         existing assets at reasonable intervals and appropriate action is taken
         with respect to any differences.

                  (cc) The Company and each of its Subsidiaries carries, or is
         covered by, insurance with insurers of nationally recognized
         reputability in such amounts and covering such risks as it believes is
         customary for companies engaged in similar industries to protect it
         from material liabilities; and neither the Company nor any of its
         Subsidiaries (i) has received notice from any insurer or agent of such
         insurer that substantial capital improvements or other material
         expenditures will have to be made in order to continue such insurance
         or (ii) has any reason to believe that it will not be able to renew its
         existing insurance coverage as and when such coverage expires or to
         obtain similar coverage from similar insurers at a cost that would not,
         singly or in the aggregate, have a Material Adverse Effect.

                  (dd) The statements in the Prospectus under the caption
         "Related Party Transactions" set forth all existing agreements,
         arrangements, understandings or transactions, or proposed agreements,
         arrangements, understandings or transactions, between or among the
         Company, on the one hand, and any officer, director or stockholder of
         the Company, or with any partner, affiliate or associate of any of the
         foregoing persons or entities, on the other hand, required to be set
         forth or described thereunder.

                  (ee) The Company has not and will not distribute prior to the
         later of (i) the Closing Date, or any date on which Option Stock is to
         be purchased, as the case may be, and (ii) completion of the
         distribution of the Stock, any offering material (including, without
         limitation, content on its website, if any, that may be deemed to be
         offering material) in connection with the offering and sale of the
         Stock other than any Preliminary Prospectuses, the Prospectus, the
         Registration Statement and other materials, if any, permitted by the
         Securities Act.

                  (ff) The Company has not incurred any liability for any
         finder's fees or similar payments in connection with the transactions
         contemplated hereby other than to the Underwriters.

                  (gg) The Company has not offered, or caused any Underwriter to
         offer, Stock to any person pursuant to the Directed Share Program with
         the specific intent to unlawfully influence (i) a customer or supplier
         of the Company to alter the customer's or supplier's level or type of
         business with the Company or (ii) a trade journalist or publication to
         write or publish favorable information about the Company or its
         products.

                  (hh) All sales of the Company's securities prior to the date
         hereof were at all relevant times duly registered under the Securities
         Act and applicable foreign securities laws and state securities or Blue
         Sky laws or were exempt from the registration requirements of the
         Securities Act and applicable foreign and state securities laws, or if

                                       9


         such securities were not registered or exempt in compliance with the
         Securities Act and applicable foreign and state securities laws, any
         private rights of action for recission or damages arising from the
         failure to register any such securities are time barred by applicable
         statutes of limitations or equitable principles, including laches.

                  (ii) The Company has obtained the agreement of (A) each of its
         directors and officers, (B) the holders of at least [__]% of the
         outstanding Common Stock; and (C) the holders of other securities
         convertible into or exercisable or exchangeable for Common Stock or
         warrants or other rights to purchase Common Stock (such that the
         aggregate of such securities that are not subject to such agreement
         does not represent more than [__]% of the outstanding Common Stock),
         not to sell, contract to sell, transfer the economic risk of ownership
         in, make any short sale, pledge or otherwise dispose of, directly or
         indirectly, any shares of Common Stock or securities convertible into
         or exercisable or exchangeable for Common Stock or warrants or other
         rights to purchase Common Stock for a period of 180 days after the date
         of the Prospectus.

                  (jj) Each certificate signed by an officer of the Company and
         delivered to the Underwriters or counsel for the Underwriters in
         connection with the issuance and sale of the Common Stock shall be
         deemed to be a representation and warranty by the Company to the
         Underwriters as to the matters covered thereby.

3.       PURCHASE OF THE STOCK BY THE UNDERWRITERS.

         (a) On the basis of the representations and warranties and subject
to the terms and conditions herein set forth, the Company agrees to issue and
sell 4,000,000 shares of the Underwritten Stock to the several Underwriters
and each of the Underwriters agrees to purchase from the Company the
respective aggregate number of shares of Underwritten Stock set forth
opposite its name in SCHEDULE I. The price at which such shares of
Underwritten Stock shall be sold by the Company and purchased by the several
Underwriters shall be $___ per share. In making this Agreement, each
Underwriter is contracting severally and not jointly; except as provided in
paragraphs (b) and (c) of this Section 3, the agreement of each Underwriter
is to purchase only the respective number of shares of the Underwritten Stock
specified in SCHEDULE I.

         (b) If for any reason one or more of the Underwriters shall fail or
refuse (otherwise than for a reason sufficient to justify the termination of
this Agreement under the provisions of Section 8 or 9 hereof) to purchase and
pay for the number of shares of the Stock agreed to be purchased by such
Underwriter or Underwriters, the Company shall immediately give notice
thereof to you, and the non-defaulting Underwriters shall have the right
within 24 hours after the receipt by you of such notice to purchase, or
procure one or more other Underwriters to purchase, in such proportions as
may be agreed upon between you and such purchasing Underwriter or
Underwriters and upon the terms herein set forth, all or any part of the
shares of the Stock which such defaulting Underwriter or Underwriters agreed
to purchase. If the non-defaulting Underwriters fail so to make such
arrangements with respect to all such shares and portion, the number of
shares of the Stock which each non-defaulting Underwriter is otherwise
obligated to purchase under this Agreement shall be automatically increased
on a pro rata basis to absorb the remaining shares and portion which the
defaulting Underwriter or Underwriters agreed to purchase; PROVIDED, HOWEVER,
that the non-defaulting Underwriters shall not be obligated to purchase the
shares and portion which the defaulting Underwriter or Underwriters agreed to
purchase if the aggregate number of such shares of the Stock exceeds 10% of
the total number of shares of the Stock which all Underwriters agreed to
purchase hereunder. If the total

                                       10


number of shares of the Stock which the defaulting Underwriter or
Underwriters agreed to purchase shall not be purchased or absorbed in
accordance with the two preceding sentences, the Company shall have the
right, within 24 hours next succeeding the 24-hour period above referred to,
to make arrangements with other underwriters or purchasers satisfactory to
you for purchase of such shares and portion on the terms herein set forth. In
any such case, either you or the Company shall have the right to postpone the
Closing Date determined as provided in Section 5 hereof for not more than
seven business days after the date originally fixed as the Closing Date
pursuant to said Section 5 in order that any necessary changes in the
Registration Statement, the Prospectus or any other documents or arrangements
may be made. If neither the non-defaulting Underwriters nor the Company shall
make arrangements within the 24-hour periods stated above for the purchase of
all the shares of the Stock which the defaulting Underwriter or Underwriters
agreed to purchase hereunder, this Agreement shall be terminated without
further act or deed and without any liability on the part of the Company to
any non-defaulting Underwriter and without any liability on the part of any
non-defaulting Underwriter to the Company. Nothing in this paragraph (b), and
no action taken hereunder, shall relieve any defaulting Underwriter from
liability in respect of any default of such Underwriter under this Agreement.

         (c) On the basis of the representations, warranties and covenants
herein contained, and subject to the terms and conditions herein set forth,
the Company grants an option to the several Underwriters to purchase,
severally and not jointly, up to 600,000 shares in the aggregate of the
Option Stock from the Company at the same price per share as the Underwriters
shall pay for the Underwritten Stock. Said option may be exercised only to
cover over-allotments in the sale of the Underwritten Stock by the
Underwriters and may be exercised in whole or in part at any time (but not
more than once) on or before the thirtieth day after the date of this
Agreement upon written or telegraphic notice by you to the Company setting
forth the aggregate number of shares of the Option Stock as to which the
several Underwriters are exercising the option. Delivery of certificates for
the shares of Option Stock, and payment therefor, shall be made as provided
in Section 5 hereof. The number of shares of the Option Stock to be purchased
by each Underwriter shall be the same percentage of the total number of
shares of the Option Stock to be purchased by the several Underwriters as
such Underwriter is purchasing of the Underwritten Stock, as adjusted by you
in such manner as you deem advisable to avoid fractional shares.

         4.       OFFERING BY UNDERWRITERS.

         (a) The terms of the initial public offering by the Underwriters of
the Stock to be purchased by them shall be as set forth in the Prospectus.
The Underwriters may from time to time change the public offering price after
the closing of the initial public offering and increase or decrease the
concessions and discounts to dealers as they may determine.

         (b) The information set forth under "Underwriting" in the
Registration Statement, any Preliminary Prospectus and the Prospectus
(insofar as such information relates to the Underwriters) constitutes the
only information furnished by the Underwriters to the Company for inclusion
in the Registration Statement, any Preliminary Prospectus, and the
Prospectus, and you on behalf of the respective Underwriters represent and
warrant to the Company that the statements made therein are correct.

                                       11


         5. DELIVERY OF AND PAYMENT FOR THE STOCK.

         (a) Delivery of certificates for the shares of the Underwritten Stock
and the Option Stock (if the option granted by Section 3(c) hereof shall have
been exercised not later than 10:00 a.m., New York time, on the date two
business days preceding the Closing Date), and payment therefor, shall be made
at the office of Milbank, Tweed, Hadley & McCloy LLP, One Chase Manhattan Plaza,
New York, New York 10005, at 10:00 a.m., New York time, on the third business
day after the date of this Agreement, or at such time on such other day, not
later than seven full business days after such fourth business day, as shall be
agreed upon in writing by the Company and you. The date and hour of such
delivery and payment (which may be postponed as provided in Section 3(b) hereof)
are herein called the Closing Date.

         (b) If the option granted by Section 3(c) hereof shall be exercised
after 10:00 a.m., New York time, on the date two business days preceding the
Closing Date, delivery of certificates for the shares of Option Stock, and
payment therefor, shall be made at the office of Milbank, Tweed, Hadley & McCloy
LLP, One Chase Manhattan Plaza, New York, New York 10005, at 10:00 a.m., New
York time, on the third business day after the exercise of such option.

         (c) Payment for the Stock purchased from the Company shall be made to
the Company or its order by wire transfer of Federal or other funds immediately
available in New York City. Such payment shall be made upon delivery of
certificates for the Stock to you for the respective accounts of the several
Underwriters against receipt therefor signed by you. Certificates for the Stock
to be delivered to you shall be registered in such name or names and shall be in
such denominations as you may request at least one business day before the
Closing Date, in the case of Underwritten Stock, and at least one business day
prior to the purchase thereof, in the case of the Option Stock. Such
certificates will be made available to the Underwriters for inspection, checking
and packaging at the offices of Lewco Securities Corporation, Two Broadway, New
York, New York 10004 on the business day prior to the Closing Date or, in the
case of the Option Stock, by 3:00 p.m., New York time, on the business day
preceding the date of purchase.

         It is understood that you, individually and not on behalf of the
Underwriters, may (but shall not be obligated to) make payment to the Company
for shares to be purchased by any Underwriter whose check shall not have been
received by you on the Closing Date or any later date on which Option Stock is
purchased for the account of such Underwriter. Any such payment by you shall not
relieve such Underwriter from any of its obligations hereunder.

         6. FURTHER AGREEMENTS OF THE COMPANY. The Company covenants and agrees
as follows:

                  (a) The Company will (i) prepare and timely file with the
         Commission under Rule 424(b) a Prospectus containing information
         previously omitted at the time of effectiveness of the Registration
         Statement in reliance on Rule 430A and (ii) not file any amendment to
         the Registration Statement or supplement to the Prospectus of which you
         shall not previously have been advised and furnished with a copy or to
         which you shall have reasonably objected in writing or which is not in
         compliance with the Securities Act or the Rules and Regulations.

                  (b) The Company will promptly notify each Underwriter in the
         event of (i) the request by the Commission for amendment of the
         Registration Statement or for

                                       12


         supplement to the Prospectus or for any additional information, (ii)
         the issuance by the Commission of any stop order suspending the
         effectiveness of the Registration Statement, (iii) the institution or
         notice of intended institution of any action or proceeding for that
         purpose, (iv) the receipt by the Company of any notification with
         respect to the suspension of the qualification of the Stock for sale
         in any jurisdiction, or (v) the receipt by it of notice of the
         initiation or threatening of any proceeding for such purpose. The
         Company will make every reasonable effort to prevent the issuance of
         such a stop order and, if such an order shall at any time be issued,
         to obtain the withdrawal thereof at the earliest possible moment.

                  (c) The Company will (i) on or before the Closing Date,
         deliver to you a signed copy of the Registration Statement as
         originally filed and of each amendment thereto filed prior to the time
         the Registration Statement becomes effective and, promptly upon the
         filing thereof, a signed copy of each post-effective amendment, if any,
         to the Registration Statement (together with, in each case, all
         exhibits thereto unless previously furnished to you) and will also
         deliver to you, for distribution to the Underwriters, a sufficient
         number of additional conformed copies of each of the foregoing (but
         without exhibits) so that one copy of each may be distributed to each
         Underwriter, (ii) as promptly as possible deliver to you and send to
         the several Underwriters, at such office or offices as you may
         designate, as many copies of the Prospectus as you may reasonably
         request, and (iii) thereafter from time to time during the period in
         which a prospectus is required by law to be delivered by an Underwriter
         or dealer, likewise send to the Underwriters as many additional copies
         of the Prospectus and as many copies of any supplement to the
         Prospectus and of any amended prospectus, filed by the Company with the
         Commission, as you may reasonably request for the purposes contemplated
         by the Securities Act.

                  (d) If at any time during the period in which a prospectus is
         required by law to be delivered by an Underwriter or dealer any event
         relating to or affecting the Company, or of which the Company shall be
         advised in writing by you, shall occur as a result of which it is
         necessary, in the opinion of counsel for the Company or of counsel for
         the Underwriters, to supplement or amend the Prospectus in order to
         make the Prospectus not misleading in the light of the circumstances
         existing at the time it is delivered to a purchaser of the Stock, the
         Company will forthwith prepare and file with the Commission a
         supplement to the Prospectus or an amended prospectus so that the
         Prospectus as so supplemented or amended will not contain any untrue
         statement of a material fact or omit to state any material fact
         necessary in order to make the statements therein, in the light of the
         circumstances existing at the time such Prospectus is delivered to such
         purchaser, not misleading. If, after the initial public offering of the
         Stock by the Underwriters and during such period, the Underwriters
         shall propose to vary the terms of offering thereof by reason of
         changes in general market conditions or otherwise, you will advise the
         Company in writing of the proposed variation, and, if in the opinion
         either of counsel for the Company or of counsel for the Underwriters
         such proposed variation requires that the Prospectus be supplemented or
         amended, the Company will forthwith prepare and file with the
         Commission a supplement to the Prospectus or an amended prospectus
         setting forth such variation. The Company authorizes the Underwriters
         and all dealers to whom any of the Stock may be sold by the several
         Underwriters to use the Prospectus, as from time to time amended or
         supplemented, in connection with the sale of the Stock in accordance
         with the applicable provisions of the Securities Act and the applicable
         rules and regulations thereunder for such period.

                                       13


                  (e) Prior to the filing thereof with the Commission, the
         Company will submit to you, for your information, a copy of any
         post-effective amendment to the Registration Statement and any
         supplement to the Prospectus or any amended prospectus proposed to be
         filed.

                  (f) The Company will cooperate, when and as requested by you,
         in the qualification of the Stock for offer and sale under the
         securities or blue sky laws of such jurisdictions as you may designate
         and, during the period in which a prospectus is required by law to be
         delivered by an Underwriter or dealer, in keeping such qualifications
         in good standing under said securities or blue sky laws; PROVIDED,
         HOWEVER, that the Company shall not be obligated to file any general
         consent to service of process or to qualify as a foreign corporation in
         any jurisdiction in which it is not so qualified. The Company will,
         from time to time, prepare and file such statements, reports, and other
         documents as are or may be required to continue such qualifications in
         effect for so long a period as you may reasonably request for
         distribution of the Stock.

                  (g) During a period of three years commencing with the date
         hereof, the Company will furnish to you, and to each Underwriter who
         may so request in writing, copies of all periodic and special reports
         furnished to stockholders of the Company and of all information,
         documents and reports filed with the Commission including the Report on
         Form SR required by Rule 463 of the Commission under the Securities
         Act.

                  (h) Not later than the 45th day following the end of the
         fiscal quarter first occurring after the first anniversary of the
         Effective Date, the Company will make generally available to its
         security holders an earnings statement in accordance with Section 11(a)
         of the Securities Act and Rule 158 thereunder.

                  (i) The Company agrees to pay all costs and expenses incident
         to the performance of its obligations under this Agreement, including
         all costs and expenses incident to (i) the preparation, printing and
         filing with the Commission and the NASD of the Registration Statement,
         any Preliminary Prospectus and the Prospectus, (ii) the furnishing to
         the Underwriters of copies of any Preliminary Prospectus and of the
         several documents required by paragraph (c) of this Section 6 to be so
         furnished, (iii) the printing of this Agreement and related documents
         delivered to the Underwriters, (iv) the preparation, printing and
         filing of all supplements and amendments to the Prospectus referred to
         in paragraph (d) of this Section 6, (v) the furnishing to you and the
         Underwriters of the reports and information referred to in paragraph
         (g) of this Section 6 and (vi) the printing and issuance of stock
         certificates, including the transfer agent's fees. Except as
         specifically provided for in this Section 6, the Underwriters will pay
         their own costs and expenses, including fees of their counsel, any
         stock transfer taxes due upon any resale of Stock by them and
         advertising costs incurred by them.

                  (j) The Company agrees to reimburse you, for the account of
         the several Underwriters, for blue sky fees and related disbursements
         (including counsel fees and disbursements and cost of printing
         memoranda for the Underwriters) paid by or for the account of the
         Underwriters or their counsel in qualifying the Stock under state
         securities or blue sky laws and in the review of the offering by the
         NASD.

                                       14


                  (k) The Company hereby agrees that, without the prior written
         consent of Chase Securities Inc. on behalf of the Underwriters, the
         Company will not, for a period of 180 days following the commencement
         of the public offering of the Stock by the Underwriters, directly or
         indirectly, (i) sell, offer, contract to sell, make any short sale,
         pledge, sell any option or contract to purchase, purchase any option or
         contract to sell, grant any option, right or warrant to purchase or
         otherwise transfer or dispose of any shares of Common Stock or any
         securities convertible into or exchangeable or exercisable for or any
         rights to purchase or acquire Common Stock or (ii) enter into any swap
         or other agreement that transfers, in whole or in part, any of the
         economic consequences or ownership of Common Stock, whether any such
         transaction described in clause (i) or (ii) above is to be settled by
         delivery of Common Stock or such other securities, in cash or
         otherwise. The foregoing sentence shall not apply to (A) shares of
         Common Stock issued by the Company upon the exercise of options granted
         under the Company's stock option plan or upon the exercise of warrants
         outstanding as of the date hereof, all as described in the Preliminary
         Prospectus, and (B) options to purchase Common Stock granted under the
         Company's stock option plan. If this Agreement is terminated prior to
         the Closing Date, the provisions of this Section 6(k) shall be of no
         further force or effect.

                  (l) The Company agrees to use its best efforts to cause all
         directors, officers, and the beneficial owners of the outstanding
         Common Stock identified on ANNEX C hereto to agree that, without the
         prior written consent of Chase Securities Inc. on behalf of the
         Underwriters, such person or entity will not, for a period of 180 days
         following the commencement of the public offering of the Stock by the
         Underwriters, directly or indirectly, sell, offer, contract to sell,
         transfer the economic risk of ownership in, make any short sale, pledge
         or otherwise dispose of any shares of Common Stock or any securities
         convertible into or exchangeable or exercisable for or any rights to
         purchase or acquire Common Stock.

                  (m) If at any time during the 25-day period after the
         Registration Statement becomes effective any rumor, publication or
         event relating to or affecting the Company shall occur as a result of
         which in your opinion the market price for the Stock has been or is
         likely to be materially affected (regardless of whether such rumor,
         publication or event necessitates a supplement to or amendment of the
         Prospectus), the Company will, after written notice from you advising
         the Company to the effect set forth above, forthwith prepare, consult
         with you concerning the substance of, and disseminate a press release
         or other public statement, reasonably satisfactory to you, responding
         to or commenting on such rumor, publication or event.

                  (n) The Company is familiar with the Investment Company Act of
         1940, as amended, and has in the past conducted its affairs, and will
         in the future conduct its affairs, in such a manner to ensure that the
         Company was not and will not be an "investment company" or a company
         "controlled" by an "investment company" within the meaning of the
         Investment Company Act of 1940, as amended, and the rules and
         regulations thereunder.

                  (o) The Company (i) will comply with all applicable securities
         and other applicable laws, rules and regulations in each jurisdiction
         in which the Directed Shares are offered and (ii) will pay all
         reasonable fees and disbursements of counsel incurred by the
         Underwriters in connection with the Directed Share Program and any
         stamp

                                       15


         duties, similar taxes or duties or other taxes, if any, incurred by
         the Underwriters in connection with the Directed Share Program.

         7.       INDEMNIFICATION AND CONTRIBUTION.

         (a) The Company agrees to indemnify and hold harmless each Underwriter
and each person (including each partner or officer thereof) who controls any
Underwriter within the meaning of Section 15 of the Securities Act from and
against any and all losses, claims, damages or liabilities, joint or several, to
which such indemnified parties or any of them may become subject under the
Securities Act, the Securities Exchange Act of 1934, as amended (herein called
the Exchange Act), or the common law or otherwise, and the Company agrees to
reimburse each such Underwriter and controlling person for any legal or other
expenses (including, except as otherwise hereinafter provided, reasonable fees
and disbursements of counsel) incurred by the respective indemnified parties in
connection with defending against any such losses, claims, damages or
liabilities or in connection with any investigation or inquiry of, or other
proceeding which may be brought against, the respective indemnified parties, in
each case arising out of or based upon (i) any untrue statement or alleged
untrue statement of a material fact contained in the Registration Statement
(including the Prospectus as part thereof and any Rule 462(b) registration
statement) or any post-effective amendment thereto (including any Rule 462(b)
registration statement), or the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading; (ii) any untrue statement or alleged untrue statement of
a material fact contained in any Preliminary Prospectus or the Prospectus (as
amended or as supplemented if the Company shall have filed with the Commission
any amendment thereof or supplement thereto) or the omission or alleged omission
to state therein a material fact necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not
misleading; (iii) any untrue statement or alleged untrue statement of a material
fact contained in any material prepared by or with the consent of the Company
for distribution to participants in connection with the Directed Share Program,
or caused by any omission or alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein not
misleading; (iv) the failure of any participant under the Directed Share Program
to pay for and accept delivery of Directed Shares that such participant has
agreed to purchase thereunder; or (v) the establishment of and any offers and
sales of Stock made under or in connection with the Directed Share Program
(other than, in the case of clause (v) above, losses, claims, damages or
liabilities (or expenses relating thereto) that are finally judicially
determined to have resulted from the bad faith or gross negligence of the
Underwriters), PROVIDED, HOWEVER, that (1) the indemnity agreements of the
Company contained in clauses (i) and (ii) of this subparagraph (a) shall not
apply to any such losses, claims, damages, liabilities or expenses if such
statement or omission was made in reliance upon and in conformity with
information furnished as herein stated or otherwise furnished in writing to the
Company by or on behalf of any Underwriter for use in any Preliminary Prospectus
or the Registration Statement or the Prospectus or any such amendment thereof or
supplement thereto and (2) the indemnity agreement contained in clauses (i) and
(ii) of this subparagraph (a) with respect to any Preliminary Prospectus shall
not inure to the benefit of any Underwriter from whom the person asserting any
such losses, claims, damages, liabilities or expenses purchased the Stock which
is the subject thereof (or to the benefit of any person controlling such
Underwriter) if at or prior to the written confirmation of the sale of such
Stock a copy of the Prospectus (or the Prospectus as amended or supplemented)
was not sent or delivered to such person and the untrue statement or omission of
a material fact contained in such Preliminary Prospectus was corrected in the
Prospectus (or the Prospectus as amended or supplemented) unless the failure is
the result of noncompliance by the Company with subparagraph (c) of Section 6
hereof. The

                                       16


indemnity agreements of the Company contained in this subparagraph (a) and
the representations and warranties of the Company contained in Section 2
hereof shall remain operative and in full force and effect regardless of any
investigation made by or on behalf of any indemnified party and shall survive
the delivery of and payment for the Stock.

         (b) Each Underwriter severally agrees to indemnify and hold harmless
the Company, each of its officers who signs the Registration Statement on his
own behalf or pursuant to a power of attorney, each of its directors, each
other Underwriter and each person (including each partner or officer thereof)
who controls the Company or any such other Underwriter within the meaning of
Section 15 of the Securities Act, from and against any and all losses,
claims, damages or liabilities, joint or several, to which such indemnified
parties or any of them may become subject under the Securities Act, the
Exchange Act, or the common law or otherwise and to reimburse each of them
for any legal or other expenses (including, except as otherwise hereinafter
provided, reasonable fees and disbursements of counsel) incurred by the
respective indemnified parties in connection with defending against any such
losses, claims, damages or liabilities or in connection with any
investigation or inquiry of, or other proceeding which may be brought
against, the respective indemnified parties, in each case arising out of or
based upon (i) any untrue statement or alleged untrue statement of a material
fact contained in the Registration Statement (including the Prospectus as
part thereof and any Rule 462(b) registration statement) or any
post-effective amendment thereto (including any Rule 462(b) registration
statement) or the omission or alleged omission to state therein a material
fact required to be stated therein or necessary to make the statements
therein not misleading or (ii) any untrue statement or alleged untrue
statement of a material fact contained in the Prospectus (as amended or as
supplemented if the Company shall have filed with the Commission any
amendment thereof or supplement thereto) or the omission or alleged omission
to state therein a material fact necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not
misleading, if such statement or omission was made in reliance upon and in
conformity with information furnished as herein stated or otherwise furnished
in writing to the Company by or on behalf of such indemnifying Underwriter
for use in the Registration Statement or the Prospectus or any such amendment
thereof or supplement thereto. The indemnity agreement of each Underwriter
contained in this subparagraph (b) shall remain operative and in full force
and effect regardless of any investigation made by or on behalf of any
indemnified party and shall survive the delivery of and payment for the Stock.

         (c) Each party indemnified under the provision of subparagraphs (a)
and (b) of this Section 7 agrees that, upon the service of a summons or other
initial legal process upon it in any action or suit instituted against it or
upon its receipt of written notification of the commencement of any
investigation or inquiry of, or proceeding against, it in respect of which
indemnity may be sought on account of any indemnity agreement contained in
such paragraphs, it will promptly give written notice (herein called the
Notice) of such service or notification to the party or parties from whom
indemnification may be sought hereunder. No indemnification provided for in
such paragraphs shall be available to any party who shall fail so to give the
Notice if the party to whom such Notice was not given was unaware of the
action, suit, investigation, inquiry or proceeding to which the Notice would
have related and was prejudiced by the failure to give the Notice, but the
omission so to notify such indemnifying party or parties of any such service
or notification shall not relieve such indemnifying party or parties from any
liability which it or they may have to the indemnified party for contribution
or otherwise than on account of such indemnity agreement. Any indemnifying
party shall be entitled at its own expense to participate in the defense of
any action, suit or proceeding against, or investigation or inquiry of, an
indemnified party. Any indemnifying party shall be entitled,

                                       17


if it so elects within a reasonable time after receipt of the Notice by
giving written notice (herein called the Notice of Defense) to the
indemnified party, to assume (alone or in conjunction with any other
indemnifying party or parties) the entire defense of such action, suit,
investigation, inquiry or proceeding, in which event such defense shall be
conducted, at the expense of the indemnifying party or parties, by counsel
chosen by such indemnifying party or parties and reasonably satisfactory to
the indemnified party or parties; PROVIDED, HOWEVER, that (i) if the
indemnified party or parties reasonably determine that there may be a
conflict between the positions of the indemnifying party or parties and of
the indemnified party or parties in conducting the defense of such action,
suit, investigation, inquiry or proceeding or that there may be legal
defenses available to such indemnified party or parties different from or in
addition to those available to the indemnifying party or parties, then
counsel for the indemnified party or parties shall be entitled to conduct the
defense to the extent reasonably determined by such counsel to be necessary
to protect the interests of the indemnified party or parties, (ii) in any
event, the indemnified party or parties shall be entitled to have counsel
chosen by such indemnified party or parties participate in, but not conduct,
the defense, (iii) if the indemnified parties under this Section 7 consist of
the Underwriters or any of their officers, employees or controlling persons,
then any such counsel chosen for such indemnified parties shall be designated
in writing by Chase Securities Inc., and (iv) if the indemnified parties
under this Section 7 consist of the Company or any of its officers, employees
or controlling persons, then any such counsel chosen for such indemnified
parties shall be designated in writing by the Company. If, within a
reasonable time after receipt of the Notice, an indemnifying party gives a
Notice of Defense and the counsel chosen by the indemnifying party or parties
is reasonably satisfactory to the indemnified party or parties, the
indemnifying party or parties will not be liable under subparagraphs (a)
through (c) of this Section 7 for any legal or other expenses subsequently
incurred by the indemnified party or parties in connection with the defense
of the action, suit, investigation, inquiry or proceeding, except that (A)
the indemnifying party or parties shall bear the legal and other expenses
incurred in connection with the conduct of the defense as referred to in
clause (i) of the proviso to the preceding sentence (provided, however, that
the indemnifying party shall not be liable for more than one separate firm
for all such indemnified parties) and (B) the indemnifying party or parties
shall bear such other expenses as it or they have authorized to be incurred
by the indemnified party or parties. If, within a reasonable time after
receipt of the Notice, no Notice of Defense has been given, the indemnifying
party or parties shall be responsible for any legal or other expenses
incurred by the indemnified party or parties in connection with the defense
of the action, suit, investigation, inquiry or proceeding.

         (d) If the indemnification provided for in this Section 7 is
unavailable or insufficient to hold harmless an indemnified party under
subparagraph (a) or (b) of this Section 7, then each indemnifying party, in
lieu of indemnifying such indemnified party, shall contribute to the amount
paid or payable by such indemnified party as a result of the losses, claims,
damages or liabilities referred to in subparagraph (a) or (b) of this Section
7 (i) in such proportion as is appropriate to reflect the relative benefits
received by each indemnifying party from the offering of the Stock or (ii) if
the allocation provided by clause (i) above is not permitted by applicable
law, in such proportion as is appropriate to reflect not only the relative
benefits referred to in clause (i) above but also the relative fault of each
indemnifying party in connection with the statements or omissions that
resulted in such losses, claims, damages or liabilities, or actions in
respect thereof, as well as any other relevant equitable considerations. The
relative benefits received by the Company and the Underwriters shall be
deemed to be in the same respective proportions as the total net proceeds
from the offering of the Stock received by the Company and the total
underwriting discount received by the Underwriters, as set forth in the table
on the cover page of the Prospectus, bear to the aggregate public offering
price of

                                       18


the Stock. Relative fault shall be determined by reference to, among other
things, whether the untrue or alleged untrue statement of a material fact or
the omission or alleged omission to state a material fact relates to
information supplied by each indemnifying party and the parties' relative
intent, knowledge, access to information and opportunity to correct or
prevent such untrue statement or omission.

         The parties agree that it would not be just and equitable if
contributions pursuant to this subparagraph (d) were to be determined by pro
rata allocation (even if the Underwriters were treated as one entity for such
purpose) or by any other method of allocation which does not take into
account the equitable considerations referred to in the first sentence of
this subparagraph (d). The amount paid by an indemnified party as a result of
the losses, claims, damages or liabilities, or actions in respect thereof,
referred to in the first sentence of this subparagraph (d) shall be deemed to
include any legal or other expenses reasonably incurred by such indemnified
party in connection with investigation, preparing to defend or defending
against any action or claim which is the subject of this subparagraph (d).
Notwithstanding the provisions of this subparagraph (d), no Underwriter shall
be required to contribute any amount in excess of the underwriting discount
applicable to the Stock purchased by such Underwriter. No person guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) shall be entitled to contribution from any person who was not
guilty of such fraudulent misrepresentation. The Underwriters' obligations in
this subparagraph (d) to contribute are several in proportion to their
respective underwriting obligations and not joint.

         Each party entitled to contribution agrees that upon the service of
a summons or other initial legal process upon it in any action instituted
against it in respect of which contribution may be sought, it will promptly
give written notice of such service to the party or parties from whom
contribution may be sought, but the omission so to notify such party or
parties of any such service shall not relieve the party from whom
contribution may be sought from any obligation it may have hereunder or
otherwise (except as specifically provided in subparagraph (c) of this
Section 7).

         (e) The Company will not, without the prior written consent of each
Underwriter, settle or compromise or consent to the entry of any judgment in
any pending or threatened claim, action, suit or proceeding in respect of
which indemnification may be sought hereunder (whether or not such
Underwriter or any person who controls such Underwriter within the meaning of
Section 15 of the Securities Act or Section 20 of the Exchange Act is a party
to such claim, action, suit or proceeding) unless such settlement, compromise
or consent includes an unconditional release of such Underwriter and each
such controlling person from all liability arising out of such claim, action,
suit or proceeding.

         8. TERMINATION. This Agreement may be terminated by you at any time
prior to the Closing Date by giving written notice to the Company if after
the date of this Agreement trading in the Common Stock shall have been
suspended, or if there shall have occurred (i) the engagement in hostilities
or an escalation of major hostilities by the United States or the declaration
of war or a national emergency by the United States on or after the date
hereof, (ii) any outbreak of hostilities or other national or international
calamity or crisis or change in economic or political conditions if the
effect of such outbreak, calamity, crisis or change in economic or political
conditions in the financial markets of the United States would, in the
Underwriters' reasonable judgment, make the offering or delivery of the Stock
impracticable, (iii) suspension of trading in securities generally or a
material adverse decline in value of securities generally on the New York
Stock Exchange, the American Stock Exchange, The Nasdaq Stock Market, or
limitations on prices (other than limitations on hours or numbers of

                                       19


days of trading) for securities on either such exchange or system, (iv) the
enactment, publication, decree or other promulgation of any federal or state
statute, regulation, rule or order of, or commencement of any proceeding or
investigation by, any court, legislative body, agency or other governmental
authority which in the Underwriters' reasonable opinion materially and
adversely affects or will materially or adversely affect the business or
operations of the Company, (v) declaration of a banking moratorium by either
federal or New York State authorities or (vi) the taking of any action by any
federal, state or local government or agency in respect of its monetary or
fiscal affairs which in the Underwriters' reasonable opinion has a material
adverse effect on the securities markets in the United States. If this
Agreement shall be terminated pursuant to this Section 8, there shall be no
liability of the Company to the Underwriters and no liability of the
Underwriters to the Company; PROVIDED, HOWEVER, that in the event of any such
termination, the indemnity and contribution agreements contained in Section 7
hereof shall survive such termination and (y) the Company agrees to indemnify
and hold harmless the Underwriters from all costs or expenses incident to the
performance of the obligations of the Company under this Agreement, including
all costs and expenses referred to in subparagraphs (i) and (j) of Section 6
hereof.

         9. CONDITIONS OF UNDERWRITERS' OBLIGATIONS. The obligations of the
several Underwriters to purchase and pay for the Stock shall be subject to
the performance by the Company of all its obligations to be performed
hereunder at or prior to the Closing Date or any later date on which Option
Stock is to be purchased, as the case may be, and to the following further
conditions:

                  (a) The Registration Statement shall have become effective;
         and no stop order suspending the effectiveness thereof shall have been
         issued and no proceedings therefor shall be pending or threatened by
         the Commission.

                  (b) The legality and sufficiency of the sale of the Stock
         hereunder and the validity and form of the certificates representing
         the Stock, all corporate proceedings and other legal matters incident
         to the foregoing, and the form of the Registration Statement and of the
         Prospectus (except as to the financial statements contained therein),
         shall have been approved at or prior to the Closing Date by Milbank,
         Tweed, Hadley & McCloy LLP, counsel for the Underwriters.

                  (c) You shall have received from Kutak Rock LLP, counsel for
         the Company, and from William B. Walker, Esq., Vice President of
         Intellectual Property for the Company, opinions, addressed to the
         Underwriters and dated the Closing Date, covering the matters set forth
         in ANNEX A and ANNEX B hereto, respectively, and if Option Stock is
         purchased at any date after the Closing Date, additional opinions from
         each such counsel, addressed to the Underwriters and dated such later
         date, confirming that the statements expressed as of the Closing Date
         in such opinions remain valid as of such later date.

                  (d) You shall be satisfied that (i) as of the Effective Date,
         the statements made in the Registration Statement and the Prospectus
         were true and correct and neither the Registration Statement nor the
         Prospectus omitted to state any material fact required to be stated
         therein or necessary in order to make the statements therein,
         respectively, not misleading, (ii) since the Effective Date, no event
         has occurred which should have been set forth in a supplement or
         amendment to the Prospectus which has not been set forth in such a
         supplement or amendment, (iii) since the respective dates as of which
         information is given in the Registration Statement in the form in which
         it originally

                                       20


         became effective and the Prospectus contained therein, there has not
         been any material adverse change or any development involving a
         prospective material adverse change in or affecting the business,
         properties, financial condition or results of operations of the
         Company and its Subsidiaries, taken as a whole, whether or not
         arising from transactions in the ordinary course of business, and,
         since such dates, except in the ordinary course of business, neither
         the Company nor any of its Subsidiaries has entered into any material
         transaction not referred to in the Registration Statement in the form
         in which it originally became effective and the Prospectus contained
         therein, (iv) neither the Company nor any of its Subsidiaries has any
         material contingent obligations which are not disclosed in the
         Registration Statement and the Prospectus, (v) there are not any
         pending or known threatened legal proceedings to which the Company or
         any of its Subsidiaries is a party or of which property of the Company
         or any of its Subsidiaries is the subject which are material and which
         are not disclosed in the Registration Statement and the Prospectus,
         (vi) there are not any franchises, contracts, leases or other documents
         which are required to be filed as exhibits to the Registration
         Statement which have not been filed as required, (vii) the
         representations and warranties of the Company herein are true and
         correct in all material respects as of the Closing Date or any later
         date on which Option Stock is to be purchased, as the case may be, and
         (viii) there has not been any material change in the market for
         securities in general or in political, financial or economic conditions
         from those reasonably foreseeable as to render it impracticable in your
         reasonable judgment to make a public offering of the Stock, or a
         material adverse change in market levels for securities in general (or
         those of companies in particular) or financial or economic conditions
         which render it inadvisable to proceed.

                  (e) You shall have received on the Closing Date and on any
         later date on which Option Stock is purchased a certificate, dated the
         Closing Date or such later date, as the case may be, and signed by the
         President and the Chief Financial Officer of the Company, stating that
         the respective signers of said certificate have carefully examined the
         Registration Statement in the form in which it originally became
         effective and the Prospectus contained therein and any supplements or
         amendments thereto, and that the statements included in clauses (i)
         through (vii) of subparagraph (d) of this Section 9 are true and
         correct.

                  (f) You shall have received from Deloitte & Touche LLP, a
         letter or letters, addressed to the Underwriters and dated the Closing
         Date and any later date on which Option Stock is purchased, confirming
         that they are independent public accountants with respect to the
         Company within the meaning of the Securities Act and the applicable
         published rules and regulations thereunder and based upon the
         procedures described in their letter delivered to you concurrently with
         the execution of this Agreement (herein called the Original Letter),
         but carried out to a date not more than three business days prior to
         the Closing Date or such later date on which Option Stock is purchased
         (i) confirming, to the extent true, that the statements and conclusions
         set forth in the Original Letter are accurate as of the Closing Date or
         such later date, as the case may be, and (ii) setting forth any
         revisions and additions to the statements and conclusions set forth in
         the Original Letter which are necessary to reflect any changes in the
         facts described in the Original Letter since the date of the Original
         Letter or to reflect the availability of more recent financial
         statements, data or information. The letters shall not disclose any
         change, or any development involving a prospective change, in or
         affecting the business or properties of the Company or any of its
         Subsidiaries which, in your sole judgment, makes it impractical or
         inadvisable to proceed with the public

                                       21


         offering of the Stock or the purchase of the Option Stock as
         contemplated by the Prospectus.

                  (g) You shall have received from Deloitte & Touche LLP a
         letter stating that their review of the Company's system of internal
         accounting controls, to the extent they deemed necessary in
         establishing the scope of their examination of the Company's financial
         statements as at March 31, 2000, did not disclose any weakness in
         internal controls that they considered to be material weaknesses.

                  (h) You shall have been furnished evidence in usual written or
         telegraphic form from the appropriate authorities of the several
         jurisdictions, or other evidence satisfactory to you, of the
         qualification referred to in subparagraph (f) of Section 6 hereof.

                  (i) Prior to the Closing Date, the Stock to be issued and sold
         by the Company shall have been duly authorized for listing by the
         Nasdaq National Market upon official notice of issuance.

                  (j) On or prior to the Closing Date, you shall have received
         from all directors, officers, and the beneficial owners of the
         outstanding Common Stock identified on ANNEX C hereto, agreements, in
         form reasonably satisfactory to Chase Securities Inc., stating that
         without the prior written consent of Chase Securities Inc. on behalf of
         the Underwriters, such person or entity will not, for a period of 180
         days following the commencement of the public offering of the Stock by
         the Underwriters, directly or indirectly, sell, offer, contract to
         sell, transfer the economic risk of ownership in, make any short sale,
         pledge or otherwise dispose of any shares of Common Stock or any
         securities convertible into or exchangeable or exercisable for or any
         rights to purchase or acquire Common Stock.

                  (k) The Company shall have acquired from Nebraska State
         Bank, on terms reasonably satisfactory to you, the promissory notes
         of SD Acquisition Inc. ("SD") in an aggregate principal amount of
         $4.635 million (the "SD Notes") evidencing loans made by Nebraska
         State Bank to SD under loan agreements between the parties, dated as
         of May 15, 2000, the proceeds of which were used by SD to purchase
         the assets of the Company associated with its non-life science
         product line.  The acquisition of the SD Notes will be made
         simultaneously with the closing of the sale of the Stock to you
         hereunder and will be financed with a portion of the net offering
         proceeds.  The Company authorizes you to pay a portion of the net
         proceeds of the offering sufficient to purchase the SD Notes
         directly to Nebraska State Bank (or such other parties as it shall
         direct) at the Closing.

         In addition, you shall have received on the Closing Date and on any
later date on which Option Stock is purchased, such additional documents
(including, without limitation, opinions of counsel, letters, certificates
and agreements) as you may reasonably request.

         All the agreements, opinions, certificates and letters mentioned
above or elsewhere in this Agreement shall be deemed to be in compliance with
the provisions hereof only if Milbank, Tweed, Hadley & McCloy LLP, counsel
for the Underwriters, shall be satisfied that they comply in form and scope.

         In case any of the conditions specified in this Section 9 shall not
be fulfilled, this Agreement may be terminated by you by giving notice to the
Company. Any such termination shall be without liability of the Company to
the Underwriters and without liability of the Underwriters to the Company;
PROVIDED, HOWEVER, that (i) in the event of such termination, the Company
agrees to indemnify and hold harmless the Underwriters from all costs or
expenses incident to the performance of the obligations of the Company under
this Agreement, including all costs and expenses referred to in subparagraphs
(i) and (j) of Section 6 hereof, and (ii) if this Agreement is terminated by
you because of any refusal, inability or failure on the part of the Company
to perform any agreement herein, to fulfill any of the conditions herein, or
to comply with any provision hereof other than by reason of a default by any
of the Underwriters, the Company will reimburse the Underwriters severally
upon demand for all out-of-pocket expenses (including reasonable fees and
disbursements of counsel) that shall have been incurred by them in connection
with the transactions contemplated hereby.

                                       22


         10. CONDITIONS OF THE OBLIGATION OF THE COMPANY. The obligation of the
Company to deliver the Stock shall be subject to the conditions that:

         (a) the Registration Statement shall have become effective and no
stop order suspending the effectiveness thereof shall be in effect and no
proceedings therefor shall be pending or threatened by the Commission; and

         (b) you shall have made payment for all the Stock to be sold on the
Closing Date (or, in the case of the Option Stock, on any later date on which
Option Stock is purchased) against delivery of the certificates evidencing
such Stock, as provided in Section 5 hereof.

         In case either of the conditions specified in this Section 10 shall
not be fulfilled, this Agreement may be terminated by the Company by giving
notice to you. Any such termination shall be without liability of the Company
to the Underwriters and without liability of the Underwriters to the Company;
PROVIDED, HOWEVER, that in the event of any termination due to the
non-fulfillment of the condition set forth in subparagraph (a) of this
Section 10, the Company agrees to indemnify and hold harmless the
Underwriters from all costs or expenses incident to the performance of the
obligations of the Company under this Agreement, including all costs and
expenses referred to in subparagraphs (i) and (j) of Section 6 hereof.

         11. REIMBURSEMENT OF CERTAIN EXPENSES. With respect to its
obligations under Section 7 of this Agreement, the Company hereby agrees to
reimburse on a quarterly basis any indemnified person identified in Section 7
of this Agreement for all reasonable legal and other expenses incurred in
connection with investigating or defending any claim, action, investigation,
inquiry or other proceeding arising out of or based upon any statement or
omission, or any alleged statement or omission, described in subparagraph (a)
of Section 7 of this Agreement, notwithstanding the absence of a judicial
determination as to the propriety and enforceability of the obligations under
this Section 11 and the possibility that such payments might later be held to
be improper; PROVIDED, HOWEVER, that (i) to the extent any such payment is
ultimately held to be improper, the persons receiving such payments shall
promptly refund them and (ii) such persons shall provide to the Company, upon
request, reasonable assurances of their ability to effect any refund, when
and if due.

         12. PERSONS ENTITLED TO BENEFIT OF AGREEMENT. This Agreement shall
inure to the benefit of the Company and the several Underwriters and, with
respect to the provisions of Section 7 hereof, the several parties (in
addition to the Company and the several Underwriters) indemnified under the
provisions of said Section 7, and their respective personal representatives,
successors and assigns. Nothing in this Agreement is intended or shall be
construed to give to any other person, firm or corporation any legal or
equitable remedy or claim under or in respect of this Agreement or any
provision herein contained. The term "successors and assigns" as herein used
shall not include any purchaser, as such purchaser, of any of the Stock from
any of the several Underwriters.

         13. NOTICES. Except as otherwise provided herein, all communications
hereunder shall be in writing or by telegraph and, if to the Underwriters,
shall be mailed, telegraphed or delivered to Chase Securities Inc., One Bush
Street, San Francisco, CA 94104, with a copy to Milbank, Tweed, Hadley &
McCloy LLP, One Chase Manhattan Plaza, 47th Floor, New York, New York 10005,
Attention: Robert B. Williams, Esq.; and if to the Company, shall be mailed,
telegraphed or delivered to it at its office, 5600 South 42nd Street, Omaha,
Nebraska 68107, Attention: Collin D'Silva, with a copy to Kutak Rock LLP,
1650 Farnam Street, Omaha,

                                       23


Nebraska 68102, Attention: Steven P. Amen, Esq. All notices given by
telegraph shall be promptly confirmed by letter.

         14. MISCELLANEOUS. The reimbursement, indemnification and
contribution agreements contained in this Agreement and the representations,
warranties and covenants in this Agreement shall remain in full force and
effect regardless of (a) any investigation made by or on behalf of any
Underwriter or controlling person thereof, or by or on behalf of the Company
or their respective directors or officers, and (b) delivery and payment for
the Stock under this Agreement.

         This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

         This Agreement shall be governed by, and construed in accordance
with, the laws of the State of New York.

























                                       24


         Please sign and return to the Company the enclosed duplicates of
this letter, whereupon this letter will become a binding agreement between
the Company and the several Underwriters in accordance with its terms.

                                                  Very truly yours,

                                                  TRANSGENOMIC, INC.



                                                  By:
                                                      --------------------------
                                                      Name:
                                                      Title:


The foregoing Agreement is hereby confirmed
and accepted as of the date first above written.

CHASE SECURITIES INC.
Bear, Stearns & Co. Inc.
Dain Rauscher Incorporated
by Chase Securities Inc.



By
   ---------------------------
         Managing Director

Acting on behalf of the several Underwriters, including themselves, named in
Schedule I hereto.












                                       25


                                   SCHEDULE I

                                  UNDERWRITERS



                                                                                                   NUMBER OF
                                                                                                    SHARES
                                                                                                     TO BE
         UNDERWRITERS                                                                              PURCHASED
         ------------                                                                              ----------
                                                                                               
Chase Securities Inc.............................................................................
Bear, Stearns & Co. Inc..........................................................................
Dain Rauscher Incorporated ......................................................................

            Total ...............................................................................  4,000,000




                                     ANNEX A

             MATTERS TO BE COVERED IN THE OPINION OF KUTAK ROCK LLP
                             COUNSEL FOR THE COMPANY


                           1. The Company has been duly incorporated and is
         validly existing as a corporation in good standing under the laws of
         the State of Delaware, is duly qualified as a foreign corporation and
         in good standing in each state of the United States of America in which
         its ownership or leasing of property requires such qualification
         (except where the failure to be so qualified would not have a Material
         Adverse Effect) and has full corporate power and authority to own or
         lease its properties and conduct its business as described in the
         Registration Statement.

                           2. The authorized capital stock of the Company
         consists of 15,000,000 shares of Preferred Stock, $.01 par value, of
         which there are no outstanding shares, and 60,000,000 shares of Common
         Stock, $.01 par value, of which there are outstanding [__________]
         shares (including the Underwritten Stock plus the number of shares of
         Option Stock issued on the date hereof) and conforms as to legal
         matters to the description thereof contained in the Prospectus; proper
         corporate proceedings have been taken validly to authorize such
         authorized capital stock; all of the outstanding shares of such capital
         stock (including the Underwritten Stock and the shares of Option Stock
         issued, if any) have been duly and validly issued and are fully paid
         and nonassessable; any Option Stock purchased after the Closing Date,
         when issued and delivered to and paid for by the Underwriters as
         provided in the Underwriting Agreement, will have been duly and validly
         issued and be fully paid and nonassessable; and no preemptive rights
         of, or rights of refusal in favor of, stockholders exist with respect
         to the Stock, or the issue and sale thereof, pursuant to the
         Certificate of Incorporation or Bylaws of the Company and, to the
         knowledge of such counsel, there are no contractual preemptive rights
         that have not been waived, rights of first refusal or rights of co-sale
         which exist with respect to the issue and sale of the Stock.

                           3. The Registration Statement has become effective
         under the Securities Act and, to the best of such counsel's knowledge,
         no stop order suspending the effectiveness of the Registration
         Statement or suspending or preventing the use of the Prospectus is in
         effect and no proceedings for that purpose have been instituted or are
         pending or contemplated by the Commission; any required filing of the
         Prospectus pursuant to Rule 424(b) under the Securities Act has been
         made within the time period required by Rule 424(b); and the Prospectus
         may lawfully be used for the purposes specified in the Securities Act
         in connection with the offer and sale of the Stock in the manner
         therein specified.

                           4. The Registration Statement and the Prospectus
         (except as to the financial statements and schedules and other
         financial data contained therein, as to which such counsel need express
         no opinion) comply as to form in all material respects with the
         requirements of the Securities Act and with the Rules and Regulations.

                           5. The information required to be set forth in the
         Registration Statement in answer to Items 9, 10 (insofar as it relates
         to such counsel), 11(c) and 15 of Form S-1 is to the best of such
         counsel's knowledge accurately and adequately set forth

                                       1


         therein in all material respects or no response is required with
         respect to such Items, and the description of the Company's stock
         option plans and the options granted and which may be granted
         thereunder and the options granted otherwise than under such plans
         set forth in the Prospectus accurately and fairly presents the
         information required to be shown with respect to said plans and
         options to the extent required by the Securities Act and the rules
         and regulations of the Commission thereunder.

                           6. Such counsel does not know of any franchises,
         contracts, leases, documents or legal proceedings, pending or
         threatened, which in the opinion of such counsel are of a character
         required to be described in the Registration Statement or the
         Prospectus or to be filed as exhibits to the Registration Statement,
         which are not described and filed as required.

                           7. The Underwriting Agreement has been duly
         authorized, executed and delivered by the Company; and the Company has
         the corporate power and authority to enter into the Underwriting
         Agreement and to perform its obligations contemplated thereunder.

                           8. The issue and sale by the Company of the shares of
         Stock sold by the Company as contemplated by the Underwriting Agreement
         and the compliance by the Company with all of the provisions of the
         Underwriting Agreement will not (a) conflict with, breach or result in
         a default under, any indenture, mortgage, deed of trust, loan agreement
         or other agreement or instrument to which the Company or any of its
         Subsidiaries is a party or (b) violate the Company's charter or bylaws
         or any law, statute, rule or regulation applicable to the Company or
         any of its Subsidiaries (other than state securities or blue sky laws
         as to which no opinion need be expressed) or any judgment, decree or
         order known to such counsel and applicable to the Company or any of its
         Subsidiaries of any court or governmental agency or body having
         jurisdiction over the Company or any of its Subsidiaries or any of
         their respective properties.

                           9. Except as described in the Registration Statement
         and the Prospectus, all holders of securities of the Company having
         rights to the registration of shares of Common Stock, or other
         securities, because of the filing of the Registration Statement by the
         Company, (i) have waived such rights, (ii) have had such rights expire
         by reason of lapse of time following notification of the Company's
         intent to file the Registration Statement or (iii) have had their
         shares or other securities registered by the Company pursuant to the
         Registration Statement.

                           10. No consent, approval, authorization or order of,
         or filing or registration with, any court or governmental agency or
         body is required for the execution, delivery and performance by the
         Company of the Underwriting Agreement and the consummation of the
         transactions contemplated therein, except such as have been obtained
         under the Securities Act and such as may be required under state
         securities or blue sky laws in connection with the purchase and
         distribution of the Stock by the Underwriters (as to which such counsel
         need express no opinion).

                           11. The Company is not, and after the offer and sale
         of the Stock in the manner set forth in the Underwriting Agreement and
         in the manner contemplated in the Prospectus will not be, an
         "investment company" or a company "controlled" by an "investment
         company" within the meaning of the Investment Company Act and the rules
         and regulations thereunder.

                                       2


                           12. The Stock issued and sold by the Company will
         have been duly authorized for listing by the Nasdaq National Market
         upon official notice of issuance.

         Counsel rendering the foregoing opinion may rely as to questions of
law not involving the laws of the United States or of the State of Delaware,
upon opinions of local counsel satisfactory in form and scope to counsel for
the Underwriters. Copies of any opinions so relied upon shall be delivered to
the Representatives and to counsel for the Underwriters and the foregoing
opinion shall also state that counsel knows of no reason the Underwriters are
not entitled to rely upon the opinions of such local counsel.

                  In addition to the matters set forth above, counsel
rendering the foregoing opinion shall also include a statement to the effect
that nothing has come to the attention of such counsel that leads such
counsel to believe that the Registration Statement (except as to the
financial statements and schedules and other financial data contained
therein, as to which such counsel need not express any opinion or belief) at
the Effective Date contained any untrue statement of a material fact or
omitted to state a material fact required to be stated therein or necessary
to make the statements therein not misleading, that the Prospectus (except as
to the financial statements and schedules and other financial data contained
therein, as to which such counsel need not express any opinion or belief) as
of its date or at the Closing Date (or any later date on which Option Stock
is purchased), contained or contains any untrue statement of a material fact
or omitted or omits to state a material fact necessary in order to make the
statements therein, in light of the circumstances under which they were made,
not misleading.

























                                       3


                                     ANNEX B

          MATTERS TO BE COVERED IN THE OPINION OF WILLIAM WALKER, ESQ.
             VICE PRESIDENT OF INTELLECTUAL PROPERTY FOR THE COMPANY


                           1. The statements in the Registration Statement and
         in the Prospectus relating to Intellectual Property, under the captions
         "Risk Factors -- Our patents may not protect us from others using our
         technology which could harm our business and our competitive position";
         "Risk Factors -- We cannot be certain other measure taken to protect
         our intellectual property will be effective"; "Risk Factors -- We are
         dependent upon our licensed technologies and may need to obtain
         additional licenses in the future to offer our products and remain
         competitive"; "Risk Factors - The protection of intellectual property
         in foreign countries is uncertain"; "Risk Factors -- Our products could
         infringe on the intellectual property rights of others which could
         require us to pay substantial royalties"; "Business -- Strategy --
         Build a Substantial Intellectual Property Estate"; "Business -- Legal
         Proceedings"; and "Business -- Intellectual Property", insofar as such
         statements constitute matters of law, legal conclusions, or summaries
         of legal matters or proceedings, are accurate and complete statements
         or summaries of the matters set forth therein.

                           2. There are no pending, or to the best of such
         counsel's knowledge, threatened, legal, or governmental proceedings
         relating to any Intellectual Property that are referred to in the
         Prospectus and listed in Schedules A, B, C and D hereto.

                           3. The Company owns each of the Intellectual Property
         rights that are referred to in the Prospectus and listed in Schedules A
         and B hereto.

                           4. No security interests have been recorded in the
         U.S. Patent and Trademark Office with respect to any of the U.S.
         patents or patent applications that are referred to in the Prospectus
         and listed in Schedules A, B, C and D.

                           5. Except as described in the Prospectus, no third
         party has any rights to any of the Intellectual Property rights that
         are referred to in the Prospectus and listed in Schedules A, B, C and
         D.

                           6. No liens have been recorded against the Company
         with respect to any of the Intellectual Property rights that are
         referred to in the Prospectus and listed in Schedules A, B, C and D.

                           7. No interference has been declared or provoked with
         respect to any of the Intellectual Property rights that are referred to
         in the Prospectus and listed in Schedules A, B, C and D.

                           8. For each U.S. patent application referred to in
         the Prospectus and listed in Schedules B and D, all information known,
         to date, to be "material to patentability", as defined in 37 C.F.R.
         Section 1.56(b), has been disclosed, or will be disclosed pursuant to
         37 C.F.R. Section 1.97, to the U.S. Patent and Trademark Office.

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                           9. The Company has not received any notice
         challenging the validity or enforceability of any of the Intellectual
         Property rights that are referred to in the Prospectus and listed in
         Schedules A and C.

                           10. The micro-beads packed into the commercially
         available DNASep-Registered Trademark- chromatography columns for use
         on the WAVE-Registered Trademark- platform are covered by one or more
         of the claims of U.S. Patent No. 5,585,236.

                           11. The chromatographic processes intended for
         utilization with the commercially available WAVE-Registered Trademark-
         platform are covered by one or more of the claims of one or more of
         U.S. Patent Nos. 5,986,085, 6,024,878, 6,027,898, and 5,795,976.

                           12. The chromatographic processes intended for
         utilization with the commercially available WAVE-Registered Trademark-
         platform are covered by one or more of the claims of the one or more of
         U.S. Patent Nos. 5,972,222, 5,772,889, 5997,742, and 6,017,457.

                           13. The chromatographic processes for utilization
         with the commercially available WAVE-Registered Trademark- platform
         are covered by one or more of the claims of one or more of U.S. Patent
         Nos. 5,149,661 and 5,393,673.

                           14. The chromatographic processes intended for
         utilization with the commercially available WAVE-Registered Trademark-
         platform are covered by one or more of the claims of U.S. Patent No.
         5,338,448.

                           15. No claim which is presently pending has been
         asserted against the Company relating to the potential infringement of,
         or conflict with, any Intellectual Property rights of others.

                           16. Neither the Company nor any of its Subsidiaries
         is infringing or otherwise violating any Intellectual Property rights
         of others, and there are no infringements by others of any of Company's
         or its Subsidiaries' Intellectual Property rights which in the judgment
         of such counsel could affect materially the use thereof by the Company
         or any of its Subsidiaries.

                           17. The Company and its Subsidiaries own or possess
         sufficient Intellectual Property rights to conduct the business now
         being or proposed to be conducted by the Company and its Subsidiaries
         as described in the Prospectus.



                  In addition to the matters set forth above, such counsel
shall also state that such counsel is familiar with the technology used by
the Company and its Subsidiaries in their respective businesses and the
manner of their use thereof and has read the Registration Statement and the
Prospectus, including the portions of the Registration Statement and the
Prospectus referring to Intellectual Property and that, based thereon,
nothing has come to the attention of such counsel that leads it to believe
that Registration Statement at the Effective Date and the Prospectus at the
date thereof and as of the Closing Date contains any untrue statement of a
material fact with respect to Intellectual Property owned or used by the
Company and its Subsidiaries, or the manner of their use thereof, or omits to
state any material fact relating to Intellectual Property owned or used by
the Company and its Subsidiaries, or the manner of their use thereof, that is
required to be stated in the Registration Statement or the Prospectus or is
necessary to make the statements therein, in the light of the circumstances
under which they were made, not misleading.



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                  With respect to each of the opinions rendered in paragraphs
5, 6, 7 , 8, 16 and 17 above, such counsel may state that such opinion is
given to the best of such counsel's knowledge.



































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                                    ANNEX C


                       SECURITYHOLDERS SUBJECT TO LOCK-UP