Filed Pursuant to Form 424(b)(3)
                                                      Registration No. 333-37696

PROSPECTUS
JUNE 12, 2000

                              ISONICS CORPORATION

                            890,000 CLASS B WARRANTS
                            890,000 CLASS C WARRANTS
                  1,780,000 SHARES OF COMMON STOCK UNDERLYING
                     CLASS B WARRANTS AND CLASS C WARRANTS

    Isonics Corporation ("Isonics" or "We") hereby offers holders of outstanding
Class A Redeemable Warrants and Class A Warrants that may be issued upon the
exercise of certain outstanding warrants ("Underwriter's Warrants") the
opportunity to exchange their Class A Redeemable Warrants ("Class A Warrants")
for Class B Warrants ("Class B Warrants"). The exercise price for the Class B
Warrants is $5.80 per share. If you exercise the Class B Warrants before their
expiration date, we will issue to you one share of Common Stock and one Class C
Redeemable Warrant ("Class C Warrants"). The Class B Warrants will expire on
September 30, 2000. The Class C Warrants (which we will issue only if you
exercise the Class B Warrants) expire June 15, 2003, will be exercisable for one
share of Common Stock at a price of $10.00 per share, and will be redeemable if
our Common Stock trades at or above $15.00 per share for any 20 of 30
consecutive trading days provided a registration statement for the exercise
continues to be current and effective.

    Should you choose to do so, you may also exercise your Class B Warrants when
you submit your Class A Warrants for exchange. You must exercise your Class B
Warrants before their expiration date or you will lose your right to exercise
those warrants.

    Our Common Stock and Class A Warrants are traded in the over-the-counter
market and quoted through the OTC Bulletin Board under the symbol "ISON" and
"ISONW", respectively. On June 12, 2000, the reported closing price of our
Common Stock was $4 7/8 per share and of our Class A Warrants was $2 3/4 per
warrant.

    AN INVESTMENT IN OUR CLASS B WARRANTS AND OUR COMMON STOCK (SHOULD YOU
CHOOSE TO EXERCISE ANY OF OUR WARRANTS) INVOLVES A HIGH DEGREE OF RISK. YOU
SHOULD EXCHANGE YOUR CLASS A WARRANTS FOR CLASS B WARRANTS ONLY IF YOU ARE
PREPARED TO EXERCISE YOUR CLASS B WARRANTS PROMPTLY AND CAN THEN AFFORD A
COMPLETE LOSS OF YOUR INVESTMENT. SEE "RISK FACTORS" BEGINNING ON PAGE 6. In
deciding whether to exchange the warrants offered, you should rely only on the
information contained in this document. We have not authorized anyone to provide
you with any information that is different from this information.

    NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

    ONLY RESIDENTS OF COLORADO, DELAWARE, GEORGIA, ILLINOIS, NEVADA, AND NEW
YORK, MAY EXCHANGE THEIR CLASS A WARRANTS OR EXERCISE THEIR CLASS B WARRANTS OR
CLASS C WARRANTS. WE HAVE NOT QUALIFIED THE CLASS B WARRANTS OR CLASS C WARRANTS
UNDER THE LAWS OF ANY OTHER STATE. WHEN YOU EXERCISE THE CLASS B WARRANTS OR
CLASS C WARRANTS, YOU WILL HAVE TO PROVIDE US INFORMATION AS TO YOUR STATE OF
RESIDENCE. WE MAY SEEK QUALIFICATION FROM TIME-TO-TIME IN OTHER STATES; YOU MAY
CALL ISONICS CORPORATION AT 303-279-7900 TO DETERMINE WHETHER YOUR STATE OF
RESIDENCE HAS BEEN INCLUDED.

                               TABLE OF CONTENTS
                                 [INSIDE FRONT]



                                                                PAGE
                                                              --------
                                                           
Summary.....................................................         3
Risk Factors................................................         6
The Exchange Offer..........................................        13
Use of Proceeds.............................................        18
Management's Discussion and Analysis of Financial Condition
  and Results of Operations.................................        19
Business....................................................        27
Management..................................................        43
Security Ownership of Certain Beneficial Holders and
  Management................................................        45
Section 16(a) Beneficial Ownership Reporting Compliance.....        47
Executive Compensation......................................        49
Certain Relationships and Related Party Transactions........        54
Isonics' Capital Stock......................................        56
Market for Common Equity and Related Stockholder Matters....        59
Shares Available for Future Sale............................        60
Securities and Exchange Commission Position on
  Indemnification for Securities Act Liabilities............        60
Experts.....................................................        60
Legal Matters...............................................        61
How to Obtain Additional Information........................        61


                            ------------------------

    Isonics has not authorized anyone to give any information or make any
representation about the offering that differs from, or adds to, the information
in this prospectus or in its documents that are publicly filed with the
Securities and Exchange Commission. Therefore, if anyone does give you different
or additional information, you should not rely on it. The delivery of this
prospectus and/or the exchange of warrants of common stock does not mean that
there have not been any changes in Isonics' condition since the date of this
prospectus. If you are in a jurisdiction where it is unlawful to offer to
exchange or exercise the securities offered by this prospectus, or if you are a
person to whom it is unlawful to direct such activities, then the offer
presented by this prospectus does not extend to you. This prospectus speaks only
as of its date except where it indicates that another date applies. Documents
that are incorporated by reference in this prospectus speak only as of their
date, except where they specify that other dates apply. The information in this
prospectus is not complete and may be changed. The holders may not exchange and
exercise these securities until the registration statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to exchange or exercise these securities and it is not soliciting an offer to
exchange or exercise these securities in any state where the exchange or
exercise is not permitted.

                            ------------------------

                                       2

                                    SUMMARY

    This summary presents selected information from this prospectus. You should
carefully read this entire document and the documents to which the prospectus
refers in order to understand this offering. SEE "HOW TO OBTAIN ADDITIONAL
INFORMATION" (PAGE 61).

ISONICS CORPORATION

    Isonics is an advanced materials and technology company, which develops and
commercializes products based on enriched stable and radioactive isotopes. The
Common Stock of Isonics is traded in the over-the-counter market and is quoted
on the OTC Bulletin Board under the symbol "ISON." The market for our stock has
historically been characterized generally by low volume and broad price and
volume volatility. We cannot give any assurance that a stable trading market
will develop for our stock.

    The address of our principal executive offices and our telephone and
facsimile numbers at that address are:

           Isonics Corporation
           5906 McIntyre Street
           Golden, Colorado 80403
           Telephone No.: (303) 279-7900
           Facsimile No.: (303) 279-7300

THE EXCHANGE OFFER

    GENERAL.  Isonics hereby offers holders of our outstanding Class A Warrants
the opportunity to exchange their Class A Warrants for an equal number of
Class B Warrants. The Class B Warrants are exercisable:

    - for one share of Common Stock and one Class C Warrant,

    - for a purchase price of $5.80 per share,

    - through September 30, 2000.

When issued to holders who exercise their Class B Warrants, the Class C Warrants
will:

    - expire June 15, 2003,

    - be exercisable for one share of Common Stock at a price of $10.00 per
      share, and

    - be redeemable if our Common Stock trades at or above $15.00 per share for
      any 20 of 30 consecutive trading days.

Class A Warrants submitted for exchange will be cancelled.

    Any person who has exercised a Class A Warrant prior to this exchange offer
will be given a Class C Warrant for no additional consideration, thus giving the
Class A Warrant holder who exercised prior to this exchange offer the same value
as the Class A Warrant holders who accept this exchange offer before exercise.
Isonics will not receive any cash proceeds from the exchange, however, Isonics
will receive proceeds upon exercise of the Class B Warrants or the Class C
Warrants, if any are exercised.

    TERM OF THE EXCHANGE OFFER AND PROCEDURES FOR EXCHANGING WARRANTS.  This
exchange offer will remain open until September 30, 2000, or such later date as
the Board of Directors may determine. To submit your Class A Warrants for
exchange, you should complete the Letter of Transmittal accompanying this
prospectus and deliver it to the exchange agent, prior to the expiration of the
exchange offer, all as described in the section commencing on page 13 entitled
"THE EXCHANGE OFFER."

                                       3

    The method of delivery of Letters of Transmittal and certificates to the
exchange agent will be at the election and risk of each holder of the Class A
Warrants. The Letters of Transmittal and certificates can be sent to the
exchange agent by hand delivery, courier service, or by mail. If you send the
Letters of Transmittal and certificates by mail, we recommended that you send
them by registered mail with return receipt requested; we also recommend that
you allow a sufficient number of days to ensure that your Letter of Transmittal
and certificates are delivered to the exchange agent prior to the expiration
time.

    Isonics will determine all questions concerning the timeliness, validity,
form and eligibility of submissions. Our determination on these matters will be
binding. We may, in our sole discretion, waive any defect or irregularity, or
permit a defect or irregularity to be corrected within such time as we may
establish; alternatively, we may reject any purported submission. Letters of
Transmittal will not be deemed to have been received or accepted until all
irregularities have been waived or cured within such time as we may determine in
our sole discretion.

    NO WITHDRAWAL RIGHTS.  Any tender of the Class A Warrants to the exchange
agent will be irrevocable. A holder who has submitted his or her Class A
Warrants for exchange may not withdraw them. Isonics has the right, in its sole
discretion, to extend the expiration date of the exchange offer or offer
withdrawal rights on a case-by-case basis in the future.

    CONSEQUENCES OF FAILURE TO EXCHANGE.  There are no consequences if you fail
to exchange your Class A Warrants before the expiration date of the exchange
offer. You will continue to own your Class A Warrants, which will be subject to
the same terms and conditions as prior to the exchange offer. After the
expiration of the exchange offer, however, you will no longer have a right to
exchange your Class A Warrants for Class B Warrants.

    Any person exercising their Class A Warrants after the expiration of the
exchange offer will not have the right to receive a Class C Warrant.

    NO PROCEEDS FROM EXCHANGE OFFER.  Isonics will not receive any proceeds from
any person in connection with the exchange offer. Isonics will only receive
proceeds from persons who choose, in their discretion, to exercise the Class A
Warrants, the Class B Warrants, and/or the Class C Warrants. Any proceeds that
Isonics may receive from the exercise of warrants will be added to our working
capital and used for corporate purposes.

RISK FACTORS

    THE PURCHASE OF ISONICS COMMON STOCK INVOLVES A HIGH DEGREE OF RISK. YOU
SHOULD EXCHANGE YOUR CLASS A WARRANTS OR EXERCISE YOUR CLASS B WARRANTS OR
CLASS C WARRANTS ONLY IF YOU CAN AFFORD A COMPLETE LOSS OF YOUR INVESTMENT. SEE
"RISK FACTORS" BEGINNING ON PAGE 6. We have not authorized anyone to give you
information or to make any representation other than those contained in this
prospectus.

A NOTE ABOUT FORWARD-LOOKING STATEMENTS

    In our effort to make the information in this prospectus more meaningful,
this prospectus contains both historical and forward-looking statements. All
statements other than statements of historical fact are forward-looking
statements within the meanings of Section 27A of the Securities Act of 1933 and
Section 21E of the Securities Exchange Act of 1934. Forward-looking statements
in this prospectus are not based on historical facts, but rather reflect the
current expectations of our management concerning future results and events.

    The forward-looking statements generally can be identified by the use of
terms such as "believe," "expect," "anticipate," "intend," "plan," "foresee,"
"likely," "will" or other similar words or phrases.

                                       4

Similarly, statements that describe our objectives, plans or goals are, or may
be, forward-looking statements.

    Forward-looking statements involve known and unknown risks, uncertainties
and other factors that may cause the actual results, performance or achievements
of Isonics to be different from any future results, performance and achievements
expressed or implied by these statements. You should review carefully all
information, including the financial statements and the notes to the financial
statements included in this prospectus. In addition to the factors discussed
under "Risk Factors," the following important factors could affect future
results, causing the results to differ materially from those expressed in the
forward-looking statements in this prospectus:

    - demand for, and acceptance of, our materials;

    - changes in development, distribution and supply relationships;

    - the impact of competitive products and technologies;

    - the risk of operations in Russia and the Republic of Georgia;

    - dependence on future product development;

    - the possibility of future customer concentration;

    - our dependence on key personnel;

    - the volatility of our stock price; and

    - the impact of new technologies.

    These factors are not necessarily all of the important factors that could
cause actual results to differ materially from those expressed in the
forward-looking statements in this prospectus. Other unknown or unpredictable
factors also could have material adverse effects on the future results of
Isonics. The forward-looking statements in this prospectus are made only as of
the date of this prospectus and Isonics does not have any obligation to publicly
update any forward-looking statements to reflect subsequent events or
circumstances. Isonics cannot assure you that projected results will be
achieved.

                                       5

                                  RISK FACTORS

    You should carefully consider the risks described below before deciding
whether to invest in Isonics Corporation. If any of the contingencies discussed
in the following paragraphs or other materially adverse events actually
materialize, the business, financial condition and results of operations could
be materially and adversely affected. In such a case, the trading price of our
Common Stock could decline, and you could lose all or part of your investment.

HISTORY OF LOSSES; ENGAGING IN NEW LINES OF BUSINESS

    We have not operated profitably to date since inception. Through
October 31, 1999 (the end of our fiscal quarter immediately preceding the
Eagle-Picher transaction), we recognized accumulated losses of more than
$4,500,000 notwithstanding receiving substantial revenues from the sale of
depleted zinc and other products.

    The depleted zinc business had accounted for a significant portion of our
revenues during the past fiscal years. Following the sale of our depleted zinc
business, our primary risk is our reliance on products that have to date not
produced significant revenues. We have historically, and expect to continue to,
operate with little backlog and a significant portion of our net revenues have
been, and we believe will continue to be, derived from a limited number of
orders that are processed and shipped in the same quarter in which the orders
are received. These orders are primarily for radioisotopes. The timing of such
orders and their fulfillment has caused, and is likely to continue to cause,
material fluctuations in our operating results. Our expense levels are
relatively fixed, and prior quarters have indicated these factors will affect
our operating results for future periods.

    We are engaging in research and development to diversify our business and to
expand other lines of our business. We are now seeking to identify and evaluate
a variety of new stable isotope products and potential markets for economic and
technical feasibility. We will continue to fund research and development to
improve technologies for isotope separation and materials processing
technologies. During fiscal 1999 and 1998, research and development expenses
were $1,155,000 and $811,000, respectively. Research and development
expenditures for the nine months ended January 31, 2000, amounted to
approximately $919,000. We cannot offer any assurance that our current or future
lines of business and our research and development efforts will be profitable.
SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and "BUSINESS."

RELATIONSHIP WITH CERTAIN SUPPLIERS AND AVAILABILITY OF RAW MATERIALS

    Related to, but separate from, the sale of the depleted zinc business, we
contemporaneously signed a ten-year Supply Agreement by which we will have the
exclusive right to purchase quantities of isotopically pure silicon-28,
silicon-29, and silicon-30, and a non-exclusive right to purchase quantities of
isotopically pure carbon-12 and carbon-13 produced by Eagle-Picher from its
current and planned facilities in Oklahoma. The Supply Agreement locks-in what
we believe is a favorable purchase price for the aforementioned isotopes. As
partial consideration for the exclusivity provision, we agreed to pay
Eagle-Picher a fee equal to 3.0% of the net revenues from all sales made by us
of products incorporating enriched silicon isotopes supplied by Eagle-Picher. We
can offer no assurance that Eagle-Picher will be able to produce isotopes
meeting the specifications of the Supply Agreement for delivery to Isonics by
December 31, 2000. A delay in Eagle-Picher's ability to begin production could
force us to seek other suppliers. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and
"BUSINESS."

LIMITED SOURCES FOR RAW MATERIALS

    Stable isotopes constitute the principal raw material required for the
manufacture of our products. The principal sources for enriched stable isotopes
are suppliers in Russia and the Republic of Georgia. Oak Ridge National
Laboratory in Oak Ridge, Tennessee, which relies on government funding for

                                       6

continuing production, and certain foreign facilities in the world including
private and pseudo-governmental organizations in Great Britain, Germany, The
Netherlands and the Republic of South Africa, have the potential to produce
stable isotopes, and in certain cases, actually produce isotopes. Although
currently enriched stable isotopes are also available from additional foreign
sources, there can be no assurance that there will continue to be an adequate
supply of enriched stable isotopes. Although we expect that our current supply
contracts will be sufficient to produce most isotopes, the production processes
require various proprietary separation techniques, which although developed by
our suppliers, may not have all been tested to date and as to the success of
which there can be no assurance. These limited sources of raw materials may
result in an inability to deliver radioisotopes or other isotopes in accordance
with our contractual requirements (whether or not the failure is our fault) and
possible resulting liability. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and
"BUSINESS."

OPERATIONS IN RUSSIA AND THE REPUBLIC OF GEORGIA

    Operations in Russia and the Republic of Georgia ("Georgia") entail certain
risks. Recently, the former republics of the Soviet Union including Georgia have
experienced political, social and economic change as they obtained independence
from the former central government in Moscow. Certain of the republics,
including Russia and Georgia, have attempted to transition from a
central-controlled economy toward a market-based economy. These changes have
involved, in certain cases, armed conflict. The political or economic
instability in these republics may continue or even worsen. The supply of stable
isotopes could be directly affected by political, economic and military
conditions in Russia and Georgia. Accordingly, our operations could be
materially adversely affected if hostilities in Russia or Georgia should occur,
if trade between Russia or Georgia and the United States were interrupted, if
political conditions in Russia or Georgia disrupt transportation or processing
concerning our goods, if laws or government policies concerning foreign business
operations in Russia or Georgia change substantially, or if tariffs are
introduced. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and "BUSINESS."

DEPENDENCE ON FUTURE PRODUCT DEVELOPMENT

    On December 1, 1999, we sold our depleted zinc business, which provided 35%
of our revenues in fiscal 1999. As a result our future operations will be more
heavily dependent upon our ability to develop new products using stable and
radioisotopes and to market and sell those products profitably. While we have a
high degree of confidence we can be successful, we can expect to incur
significant operating losses until we are able to do so. Our ability to develop,
market and sell these products will depend on our suppliers' (including
Eagle-Picher) ability to meet our demand for stable and radioisotopes, as well
as, other suppliers who modify the chemical and physical forms of these
isotopes. There can be no assurance that we will be able to develop products
that can be profitably marketed and sold. SEE "BUSINESS."

CUSTOMER CONCENTRATION

    Prior to fiscal 1999, substantially all of our net revenues in any
particular period have been attributable to a limited number of customers,
primarily General Electric Corporation. Consistent with our historical
experience, our quarterly results during fiscal year 2000 were affected
materially by the level of orders received from a limited number of significant
depleted zinc users during such quarters and product shipments by us to our
depleted zinc customers during such period. Despite the sale of the depleted
zinc business, we continue to be subject to a certain degree of variability
based on the timing of sales of our stable and radioisotopes orders. We cannot
be assured that our principal customers will continue to purchase our products.
A decrease in or loss of orders from one or more major customers would have a
material and adverse effect on our financial condition and results of
operations. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and "BUSINESS."

                                       7

    While our goal is to diversify our customer base, we expect to continue to
depend upon a relatively small number of customers for a significant percentage
of our revenues for the foreseeable future. Significant reductions in sales to
any of our large customers have had and may in the future have a material
adverse effect on us. We cannot guarantee that present or future customers will
not terminate their arrangements with us or significantly change, reduce or
delay the amount of manufacturing services ordered from us. A termination of a
manufacturing relationship or change, reduction or delay in orders could harm
us.

FACTORS AFFECTING OPERATING RESULTS; VARIABILITY OF ORDERS

    We operate with little backlog. A significant portion of our net revenues
have been, and we believe will continue to be, derived from a limited number of
orders that are processed and shipped in the same quarter in which the orders
are received. The timing of such orders and their fulfillment has caused, and is
likely to continue to cause, material fluctuations in our operating results. Our
expense levels are relatively fixed, and as has been the case in prior quarters,
these factors will affect our operating results for future periods. SEE
"MANAGEMENT'S DISCUSSION AND ANALYSIS."

MANAGEMENT OF GROWTH

    We have experienced periods of rapid growth that have placed a significant
strain on our financial and managerial resources. Our ability to manage growth
effectively, particularly given our increasing scope of operations, will require
us to continue to implement and improve our management, operational, and
financial information systems, as well as to develop the management skills of
our personnel and to train, motivate and manage our employees. Our failure to
effectively manage growth could have a material adverse effect on our business,
financial condition and results of operations. SEE "BUSINESS."

DEPENDENCE ON KEY PERSONNEL

    Our future success will depend in significant part upon the continued
service of our key technical, sales and senior management personnel, including
James E. Alexander, our President and Chief Executive Officer; Boris
Rubizhevsky, our Senior Vice President, Isotope Production and Supply; Robert
Cuttriss, President of Interpro; and Herbert Hegener, Managing Director of
Chemotrade. We maintain $1,000,000 of key man life insurance on the lives of
Messrs. Alexander, Rubizhevsky and Cuttriss and all are covered by employment
agreements extending through September 2001, 2001, and 2003, respectively
(although the individuals may terminate these agreements prematurely, in their
discretion). Mr. Hegener is covered by an employment agreement extending through
the year 2001. We believe that our future success will depend in large part upon
our ability to attract and retain qualified personnel for our operations. The
failure to attract or retain such persons could materially adversely affect our
business, financial condition and results of operations. SEE "MANAGEMENT."

POSSIBLE NEED FOR ADDITIONAL FINANCING

    We anticipate no need for additional financing in the next twelve months,
but we do anticipate a need for a substantial amount of financing after the
fiscal year ending April 30, 2001. Factors that may lead to a need for
additional financing include:

    - delays in Eagle-Picher's production of silicon and carbon isotopes from
      its plant in Oklahoma, and the resulting delays in their delivery of the
      isotopes to us under the terms of the supply agreement;

    - unanticipated expenses in developing our new products or in producing or
      marketing our existing products;

                                       8

    - the necessity of having to protect and enforce our intellectual property
      rights;

    - technological and market developments; and

    - a corporate decision to expand our production capacity through capital
      investment or acquisition.

    The exercise of the Class A Warrants, the Class B Warrants, or the Class C
Warrants will provide us with some additional financing, but we cannot offer any
assurance that any warrants will be exercised. The unavailability of additional
financing, when needed, could have a material adverse effect on our business.
SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and "BUSINESS."

NO ASSURANCE AS TO VALIDITY OF INTELLECTUAL PROPERTY RIGHTS

    We rely primarily on a combination of trade secrets, confidentiality
procedures and contractual provisions to protect our technology. Despite our
efforts to protect our rights, unauthorized parties may attempt to copy aspects
of our products or to obtain and use information that we regard as proprietary.
Policing unauthorized use of our technology and products is difficult. In
addition, the laws of many countries do not protect our rights in information,
materials and intellectual property that we regard as proprietary and that are
protected under the laws of the United States. There can be no assurance that
our means of protecting our rights in proprietary information, materials and
technology will be adequate or that our competitors will not independently
develop similar information, technology, or intellectual property. SEE
"BUSINESS."

    We currently have no patents in our own name and have not filed any patent
applications. We have rights to several isotopically engineered innovations
regarding electronic and optical materials that we believe may be patentable.
Ongoing work in the area of isotope separation by chemical means may also lead
to patentable inventions. In such cases, we intend to file patent applications
for some of these modifications, improvements, and inventions and to protect
others as trade secrets. There can be no assurance, however, that patents on
such modifications, improvements or inventions will be issued or, if issued,
that such patents or modifications and improvements protected as trade secrets
will provide meaningful protection.

    In April 1999, we announced that we had entered into an exclusive licensing
agreement with Yale University that entitles us to exclusive intellectual
property rights to patents covering semiconductor devices derived for
isotopically engineered materials. The license requires payment by us of a
royalty based on a percentage of our or our sublicenses' net sales of products
derived from technology covered by the Yale patents (#5,144,409, dated
September 1, 1992, and #5,442,191, dated August 15, 1995).

    Third parties may have filed applications for or have been issued patents
and may obtain additional patents and proprietary rights related to products or
processes competitive with or similar to those of Isonics. We may not be aware
of all patents potentially adverse to our interests that may have been issued to
others and there can be no assurance that such patents do not exist or have not
been filed or may not be filed or issued. If patents have been or are issued to
others containing preclusive or conflicting claims and such claims are
ultimately determined to be valid, we may be required to obtain licenses thereto
or to develop or obtain alternate technology. There can be no assurance that
such licenses, if required, would be available on commercially acceptable terms,
if at all, or that we would be able to develop or obtain alternate technology,
which would have a material adverse effect on our business.

    There can be no assurance that the validity of any of the patents licensed
to, or that may in the future be owned by us would be upheld if challenged by
others in litigation or that our products or technologies, even if covered by
our patents, would not infringe patents owned by others. We could incur
substantial costs in defending suits brought against us, or any of our
licensors, for infringement, in suits by us against others for infringement, or
in suits contesting the validity of a patent. Any such

                                       9

proceedings may be protracted. In any suit contesting the validity of a patent,
the patent being contested would be entitled to a presumption of validity and
the contesting party would be required to demonstrate invalidity of such patent
by clear and convincing evidence. If the outcome of any such litigation were
adverse to our interests, our business would be materially adversely affected.

    In certain instances, we may choose not to seek patent protection and may
rely on trade secrets and other confidential know-how to protect our
innovations. There can be no assurance that protectable trade secrets or
know-how will be established, or if established, that they will remain protected
or that others will not independently and lawfully develop similar or superior
innovations. We require all employees to sign intellectual property assignment
and non-disclosure agreements. In certain instances, we will enter into
agreements with our employees pursuant to which the employee will be entitled to
a small royalty with respect to products developed by Isonics based upon the
employee's inventions. In addition, all directors, consultants and other parties
to whom confidential information has been or will be disclosed have or will
execute agreements containing confidentiality provisions. There can be no
assurance, however, that any such intellectual property assignment agreements
and confidentiality agreements will be complied with or will be enforceable.

COMPETITION AND RISK OF TECHNOLOGICAL OBSOLESCENCE

    Within the United States, we believe there currently is no producer of a
full range of stable enriched isotopes for commercial sale. The U.S. government
produces isotopes, but primarily for research purposes. There can be no
assurance that a third party will not contract with the U.S. government to
acquire isotopes for commercial sale. Outside the United States, many countries
and businesses produce stable and radioactive isotopes. Some of these businesses
have substantially greater capital and other resources than do we. SEE
"BUSINESS."

    Further, it is possible that future technological developments may occur,
and these developments may render our radioisotopes and stable isotopes obsolete
or non-competitive.

    Rapidly changing technology and continuing process development characterize
the market for our manufacturing services. We believe that our future success
will depend in large part upon our ability to develop and market manufacturing
services which meet changing customer needs, maintain technological leadership
and successfully anticipate or respond to technological changes in manufacturing
processes on a cost-effective and timely basis. We cannot guarantee that our
process development efforts will be successful.

    In the future, we may face substantial competition, and we may not be able
to compete successfully against present or future competitors.

ENVIRONMENTAL COMPLIANCE

    We are subject to a variety of federal, state, and local environmental
regulations relating to the use, storage, discharge and disposal of hazardous
chemicals used during the manufacturing process. While we believe that we are in
compliance with all environmental regulations, if we fail to comply with present
and future regulations we could be subject to future liabilities or the
suspension of production. In addition, these regulations could restrict our
ability to expand our facilities or could require us to acquire costly equipment
or to incur other significant expenses to comply with governmental regulations.
Historically, our costs of compliance with environmental regulations have not
been material. SEE "BUSINESS."

CONTROL BY DIRECTORS AND OFFICERS

    Even if all of the Class A Warrants are exercised (which we cannot assure),
our directors and officers will beneficially own 45.9% of the outstanding shares
of Common Stock as of June 12, 2000,

                                       10

the date of this prospectus, and, accordingly, will have the ability to elect a
majority of the directors of Isonics and otherwise control the company.
Subsequent to the date of this prospectus, shareholders converted 180,000 shares
of Series A Convertible Preferred Stock into 180,000 shares of our Common Stock.
Consequently if all of the Class A Warrants are exercised (which we cannot
assure), our directors and officers will beneficially own 45.8% of the
outstanding shares of Common Stock as of June 12, 2000. SEE "SECURITY OWNERSHIP
OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT."

PRODUCT LIABILITY EXPOSURE AND INSURANCE

    The use of our radioisotopes in radiopharmaceuticals and in clinical trials
may expose us to potential product liability risks that are inherent in the
testing, manufacture, marketing and sale of human diagnostic and therapeutic
products. We currently have product liability insurance; however, there can be
no assurance that a product liability or other claim would not materially and
adversely affect our business or financial condition. SEE "BUSINESS."

PRICE VOLATILITY

    The trading price of our securities has been subject to wide fluctuations in
response to quarter-to-quarter variations in operating results, our
announcements of technological innovations or new products by us or our
competitors, and other events or factors. The securities markets have from time
to time experienced significant price and volume fluctuations that may be
unrelated to the operating performance of particular companies. Announcements of
delays in our testing and development schedules, technological innovations or
new products by Isonics or our competitors, developments or disputes concerning
patents or proprietary rights, regulatory developments in the United States and
foreign countries, public concern as to the safety of products containing
radioactive compounds and economic and other external factors, as well as
period-to-period fluctuations in our financial results, may have a significant
impact on the market price of our securities. In addition, the realization of
any of the risks described in these "Risk Factors" could have a significant and
adverse impact on such market prices. SEE "MARKET FOR COMMON EQUITY AND RELATED
STOCKHOLDER MATTERS."

PENNY STOCK REGULATIONS

    The Securities Enforcement Remedies and Penny Stock Reform Act of 1990
requires additional disclosure relating to the market for penny stocks in
connection with trades in any stock defined as a penny stock. The SEC
Regulations generally define a penny stock to be an equity security that has a
market price of less than $5.00 per share, subject to certain exceptions. Unless
an exception is available, the regulations require the delivery, prior to any
transaction involving a penny stock, of a disclosure schedule explaining the
penny stock market and the risks associated therewith. We have, at times in the
recent past, been included within the SEC Rule 3a-51 definition of a penny
stock. When our common stock is considered to be a "penny stock", trading is
covered by Rule 15g-9 promulgated under the Securities Exchange Act of 1934 for
non-Nasdaq and non-national securities exchange listed securities. Under such
rule, broker-dealers who recommend such securities to persons other than
established customers and accredited investors must make a special written
suitability determination for the purchaser and receive the purchaser's written
agreement to a transaction prior to sale. The regulations on penny stocks limit
the ability of broker-dealers to sell our Common Stock and thus the ability of
purchasers of our Common Stock to sell their securities in the secondary market.
Isonics has, from time-to-time, been subject to the penny stock regulations. SEE
"MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS."

POTENTIAL ADVERSE MARKET IMPACT OF SHARES ELIGIBLE FOR FUTURE SALE

    Our stock price may be hurt by future sales of our shares or the perception
that such sales may occur. As of the date of this Prospectus, approximately
8,860,656 shares of Common Stock held by

                                       11

existing stockholders constitute "restricted shares" as defined in Rule 144
under the Securities Act. Subsequent to the date of this prospectus,
shareholders converted 180,000 shares of Series A Convertible Preferred Stock
into 180,000 restricted shares of our Common Stock. As of June 21, 2000,
approximately 9,040,656 shares of Common Stock held by existing stockholders
constitute "restricted shares" as defined in Rule 144 under the Securities Act.
These shares may only be sold if they are registered under the Securities Act or
sold under Rule 144 or another exemption from registration under the Securities
Act. Sales under Rule 144 are subject to the satisfaction of certain holding
periods, volume limitations, manner of sale requirements, and the availability
of current public information about us.

    A substantial portion all of our restricted shares of Common Stock are
either eligible for sale pursuant to Rule 144 or have been registered under the
Securities Act for resale by the holders, including the Common Stock covered by
this Prospectus. This will permit the sale of registered shares of Common Stock
in the open market or in privately negotiated transactions without compliance
with the requirements of Rule 144. We are unable to estimate the amount, timing
or nature of future sales of outstanding Common Stock. Sales of substantial
amounts of our Common Stock in the public market may hurt the stock's market
price. SEE "SHARES AVAILABLE FOR FUTURE SALE."

EFFECT OF OUTSTANDING CONVERTIBLE PREFERRED STOCK, OPTIONS, AND WARRANTS

    As of June 12, 2000, we had outstanding preferred stock convertible into and
options and warrants to purchase an aggregate of 6,562,166 shares of Common
Stock. Subsequent to the date of this prospectus, shareholders converted 180,000
shares of Series A Convertible Preferred Stock into 180,000 restricted shares of
our Common Stock. As of June 21, 2000, we had outstanding preferred stock
convertible into and options and warrants to purchase an aggregate of 6,382,166
shares of Common Stock. As long as these shares of convertible preferred stock
remain outstanding and the options and warrants remain unexercised, the terms
under which we could obtain additional capital may be adversely affected.
Moreover, the holders of the convertible preferred stock, options and warrants
may be expected to exercise them at a time when we would, in all likelihood, be
able to obtain any needed capital by a new offering of our securities on terms
more favorable than those provided by these securities. SEE "DESCRIPTION OF
CAPITAL STOCK."

ANTI-TAKEOVER PROVISIONS

    Our Articles of Incorporation authorize the issuance of "blank check"
preferred stock with such designations, rights, and preferences as may be
determined by our Board of Directors. Accordingly, the Board of Directors may,
without stockholder approval, issue shares of preferred stock with dividend,
liquidation, conversion, voting or other rights that could adversely affect the
voting power or other rights of the holders of our Common Stock. Preferred stock
could also be issued to discourage, delay or prevent a change in our control,
although we do not currently intend to issue any additional series of our
preferred stock. SEE "DESCRIPTION OF CAPITAL STOCK."

INDEMNIFICATION OF OFFICERS AND DIRECTORS

    Our Bylaws provide for indemnification of officers and directors to the full
extent permitted by California law. We may be required to pay certain judgments,
fines and expenses incurred by an officer or director, including reasonable
attorneys' fees, as a result of actions or proceedings in which such officers
and directors are involved by reason of being or having been an officer or
director. SEE "SECURITIES AND EXCHANGE POSITION ON INDEMNIFICATION FOR CERTAIN
LIABILITIES."

                                       12

NO DIVIDENDS ANTICIPATED TO BE PAID

    We have never paid any cash dividends on our Common Stock and we do not
anticipate paying cash dividends on our Common Stock in the future. The future
payment of dividends is directly dependent upon our future earnings, capital
requirements, financial requirements and other factors to be determined by our
Board of Directors. It is anticipated that future earnings if any, which may be
generated from our operations will be used to finance our growth, and that cash
dividends will not be paid to our stockholders. SEE "MARKET FOR COMMON EQUITY
AND RELATED STOCKHOLDER MATTERS."

RISK OF FORWARD-LOOKING INFORMATION

    We have included a significant amount of forward-looking information in this
prospectus. Because it is not possible to predict the future, there is a
significant risk that the forward-looking information will prove to be
incorrect, and perhaps materially incorrect. SEE "MANAGEMENT'S DISCUSSION AND
ANALYSIS."

                               THE EXCHANGE OFFER

BACKGROUND OF AND REASONS FOR THE EXCHANGE OFFER

    In connection with Isonics' underwritten initial public offering completed
in September 1997, an underwriter sold 810,000 Units consisting of 810,000
shares of Common Stock, and 810,000 Class A Warrants. Each Class A Warrant
entitles the holder to purchase one share of Common Stock through September 21,
2001. The Class A Warrants expire after September 21, 2001, and the Class A
Warrants will then become valueless. As of June 12, 2000, no person has
exercised any Class A Warrants.

    At the time we completed our initial public offering, we also sold 80,000
additional warrants to the underwriter (the "Underwriter Warrants"), all of
which remain outstanding. The holders of the Underwriter Warrants are entitled
to exercise these warrants by paying us $9.57 per warrant, and the holders will
then receive a single share of our common stock and a Class A Warrant. In order
for any person holding an Underwriter Warrant to participate in the exchange, he
or she will have to first exercise the Underwriter Warrant and then submit the
Class A Warrants received for exchange.

    We are offering holders of outstanding Class A Warrants the opportunity to
exchange their Class A Warrants for Class B Warrants in order to encourage the
early exercise of our outstanding warrants. As an incentive to encourage
exercise, each Class B Warrant is exercisable for one share of Common Stock and
one additional Class C Warrant to purchase one share of Common Stock. Persons
who retain their Class A Warrants will be entitled to exercise their warrants
for a longer period of time than those who exchange their Class A Warrants for
Class B Warrants (since the Class A Warrants expire September 21, 2001), but
persons holding Class A Warrants after the exchange offer expires will not have
the right to obtain a Class C Warrant.

PURPOSE OF THE EXCHANGE OFFER

    We are offering holders of our outstanding Class A Warrants the opportunity
to exchange their Class A Warrants for Class B Warrants. We are doing so to
encourage the earlier exercise of the outstanding warrants. As an incentive,
each Class B Warrant is exercisable for one share of Common Stock and one
Class C Warrant. Isonics also hopes that the exchange may have a positive effect
on the liquidity of and the public market for its Common Stock by increasing the
number of publicly-held shares of our common stock, although we cannot be sure
whether the exchange offer will have this or any other beneficial effect. The
following chart sets forth the principal differences between the Class A
Warrants, the Class B Warrants, and the Class C Warrants. This chart is only a
summary, and for further information you should review

    - the Warrant Agreement dated September 22, 1997, between Isonics and
      Continental Stock Transfer & Trust Company for the Class A Warrants, and

    - the Warrant Agreement dated June 1, 2000, between Isonics and Continental
      Stock Transfer & Trust Company for the Class B Warrants and Class C
      Warrants.

                                       13

                  SUMMARY OF DIFFERENCES BETWEEN THE WARRANTS



                             CLASS A WARRANTS              CLASS B WARRANTS                CLASS C WARRANTS
                       ----------------------------  ----------------------------  --------------------------------
                                                                                   (ISSUABLE ONLY UPON THE EXERCISE
                                                                                         OF CLASS B WARRANTS)
                                                                          
Expiration Date......  September 21, 2001            September 30, 2000            June 15, 2003

Exercise Price.......  $5.80                         $5.80                         $10.00

Product of Exercise..  Each person exercising a      Each person exercising a      Each person exercising a Class C
                       Class A Warrant will receive  Class B Warrant will receive  Warrant will receive one share
                       one share of Common Stock     one share of common stock     of common stock
                                                     and one Class C Warrant

Redemption
  Provisions.........  We may redeem the Class A     The Class B Warrants will     We may redeem the Class C
                       Warrants at a price of $0.10  not be redeemable             Warrants at a price of $0.10 per
                       per Warrant on not less than                                Warrant on not less than 30
                       30 days' prior written                                      days' prior written notice if
                       notice if the average price                                 our Common Stock trades at or
                       of the Common Stock has been                                above $15.00 per share (subject
                       at least $14.50 per share                                   to adjustment) for any 20 of 30
                       (subject to adjustment) for                                 consecutive trading days ending
                       at least 20 consecutive                                     not more than three days before
                       trading days ending within                                  the notice of redemption is
                       three days prior to the date                                deposited in the United States
                       on which notice of                                          mails.
                       redemption is given.

Dilution Provisions..  The number of shares of       The Class B Warrants will be  The Class C Warrants will be
                       Common Stock issuable upon    subject to similar dilution   subject to similar dilution
                       exercise is subject to        adjustment provisions         adjustment provisions
                       adjustment in a number of
                       circumstances

Ability to Trade.....  The Class A Warrants have     A public market may develop   A public market may develop for
                       historically traded on the    for the Class B Warrants.     the Class C Warrants.
                       Over-The-Counter Bulletin
                       Board.

                       There can be no assurance     There can be no assurance     There can be no assurance that a
                       that the market will          that a market for the Class   market for the Class C Warrants
                       continue.                     B Warrants will develop or,   will develop or, if it develops,
                                                     if it develops, will          will continue
                                                     continue.

Registration.........  The Class A Warrants are      We expect that the            We expect that the registration
                       registered under the          registration of the Class B   of the Class C Warrants under
                       Securities Exchange Act of    Warrants under the 1934 Act   the 1934 Act will become
                       1934, as amended.             will become effective on the  effective on the date of this
                                                     date of this prospectus.      prospectus.

Warrant Holders are
  not shareholders...  Holders of Class A Warrants   Holders of Class B Warrants   Holders of Class C Warrants are
                       are not considered to be      are not considered to be      not considered to be
                       Shareholders of Isonics, and  Shareholders of Isonics, and  Shareholders of Isonics, and do
                       do not have the right to      do not have the right to      not have the right to vote at
                       vote at shareholders'         vote at shareholders'         shareholders' meetings or to
                       meetings or to receive        meetings or to receive        receive dividends when and if
                       dividends when and if         dividends when and if         declared.
                       declared.                     declared.


                                       14

    If all Class A Warrants are exchanged, we will issue an aggregate of 810,000
Class B Warrants (890,000 if the holders exercise the Underwriter Warrants and
exchange the Class A Warrants received). All Class A Warrants submitted for
exchange will be cancelled.

    If a holder exercised his or her Class A Warrant prior to this exchange
offer, we will issue a Class C Warrant to that person for no additional
consideration.

RECOMMENDATION OF THE BOARD OF DIRECTORS

    The Board of Directors believes that this exchange offer is in the best
interests of Isonics and holders of Class A Warrants, and recommends that
holders of Class A Warrants participate in the exchange offer.

CONSEQUENCES OF FAILURE TO EXCHANGE

    There are no consequences if you fail to exchange your Class A Warrants
before the expiration date of the exchange offer. You will continue to own your
Class A Warrants, which will be subject to the same terms and conditions as
prior to the exchange offer. After the expiration of the exchange offer,
however, you will no longer have a right to exchange your Class A Warrants for
Class B Warrants.

EXPIRATION TIME, EXTENSION, AMENDMENTS

    The exchange offer will expire at 5:00 p.m., Mountain Time, on
September 30, 2000, unless the expiration time is extended at the discretion of
the Board of Directors.

    Notwithstanding the foregoing, Isonics expressly reserves the right in its
sole and absolute discretion, subject to applicable law, at any time and from
time to time,

    - to delay the acceptance of the Class A Warrants for exchange,

    - to terminate the exchange offer at any time (whether or not any Class A
      Warrants have been accepted for exchange),

    - to extend the expiration time of the exchange offer and retain all
      Class A Warrants tendered, or to offer withdrawal rights on a case-by-case
      basis, and

    - to waive any condition or otherwise amend the terms of the exchange offer
      in any respect.

    If this exchange offer is amended in a manner determined by Isonics to
constitute a material change, or if Isonics waives a material condition of the
exchange offer, Isonics will promptly notify the exchange agent. We will also
make a public announcement of any extension no later than 9:00 a.m., Mountain
Time, on the business day immediately following the previously scheduled
expiration date. Without limiting the manner in which Isonics may choose to make
any public announcement and subject to applicable law, Isonics shall have no
obligation to publish, advertise or otherwise communicate any such public
announcement other than by issuing a release to an appropriate news agency. If
Isonics makes a material change to the exchange offer, we will extend the
exchange to the extent required by law.

TERMS OF THE EXCHANGE AND PROCEDURE FOR SUBMITTING CLASS A WARRANTS

    For each Class A Warrant validly submitted for exchange, Isonics will issue
one Class B Warrant. The terms of the Class B Warrant are as follows:

    - Isonics will issue to the holder who exercises a Class B Warrant one share
      of common stock and one Class C Warrant;

                                       15

    - The exercise price of the Class B Warrants is $5.80 per Class B Warrant
      (subject to adjustment);

    - The Class B Warrants will expire on September 30, 2000; and

    - Because of the applicability of state securities laws, only residents of
      certain states as set forth on the cover page of this prospectus are
      permitted to exchange their Class A Warrants or exercise their Class B
      Warrants.

    As set forth above, each person who exercises a Class B Warrant (or who has
previously exercised a Class A Warrant) will receive a Class C Warrant. The
terms of the Class C Warrants are as follows:

    - Isonics will issue to the holder who exercises a Class C Warrant one share
      of common stock;

    - The exercise price of the Class C Warrants is $10.00 per Class C Warrant
      (subject to adjustment);

    - The Class C Warrants will expire on June 15, 2003;

    - Because of the applicability of state securities laws, only residents of
      certain states as set forth on the cover page of this prospectus will be
      permitted to exercise their Class C Warrants;

    - The Class C Warrants will be redeemable if our Common Stock trades at or
      above $15.00 per share (subject to adjustment) for any 20 of 30
      consecutive trading days ending not more than three days before the notice
      of redemption is deposited in the United States mails.

    The Class B Warrants and Class C Warrants and the underlying shares of
Common Stock have been registered under the Securities Act. All share and
warrant certificates will be registered in the exact same name as the original
certificates.

    The exchange offer is not conditioned upon any minimum number of Class A
Warrants being submitted for exchange. As of the date of this prospectus,
810,000 Class A Warrants were outstanding, and an additional 80,000 Class A
Warrants are issuable upon exercise of the outstanding Underwriter Warrants.

    No person has any appraisal or dissenters' rights in connection with the
exchange offer. Class A Warrants, which are not submitted for exchange, or are
submitted but not accepted for exchange will remain outstanding. After this
exchange offer expires, holders of Class A Warrants will not have an opportunity
to exchange their Class A Warrants for Class B Warrants or any similar rights.
Isonics does not currently intend to make another exchange offer with respect to
any Class A Warrants outstanding after the expiration of this exchange offer.

    If any Class A Warrants are not accepted for exchange because of an invalid
tender, the occurrence of certain other events set forth herein or otherwise,
certificates for any such unaccepted securities will be returned, without
expense, to the holder promptly after the expiration date. Holders who submit
Class A Warrants will not be required to pay brokerage commissions or fees or,
subject to the instructions in the Letter of Transmittal, transfer taxes with
respect to the exchange offer.

    In order to make a valid delivery for exchange of Class A Warrants, a holder
must deliver the certificates representing such securities, together with a
properly completed and executed Letter of Transmittal (or copy thereof),
including all required signatures, signature guarantees, and other documents, to
the exchange agent by registered mail, return receipt requested, overnight
courier, or hand delivery as follows:

    Continental Stock Transfer & Trust Co., Inc.
    2 Broadway
    New York, NY 10004
    Attn: Compliance Department
    Telephone number: 212-509-4000.

                                       16

    Delivery to an address and in a manner other than those indicated above does
not constitute good delivery to the exchange agent.

    The method of delivery of the Letter of Transmittal and certificates to the
exchange agent will be at the election and risk of each holder of the Class A
Warrants. The Letters of Transmittal and certificates can be sent to the
exchange agent by hand delivery, courier service, or by mail. If you send the
Letters of Transmittal and certificates by mail, we recommended that you send
them by registered mail with return receipt requested; we also recommend that
you allow a sufficient number of days to ensure that the transmittal and
certificates are delivered to the exchange agent prior to the expiration time.

    All questions concerning the timeliness, validity, form, and eligibility of
submissions will be determined by Isonics, whose determinations will be final
and binding. Isonics in its sole discretion may waive any defect or
irregularity, or permit a defect or irregularity to be corrected within such
time as it may determine, or reject any purported submission. Letters of
Transmittal will not be deemed to have been received or accepted until all
irregularities have been waived or cured within such time as Isonics determines
in its sole discretion. Neither Isonics nor the exchange agent will be under any
duty to give notification of any defect or irregularity in connection with the
submission of Letters of Transmittal or incur any liability for failure to give
such notification.

NO WITHDRAWAL RIGHTS

    Any tender of the Class A Warrants to the exchange agent will be
irrevocable. A holder who has submitted his or her Class A Warrants for exchange
may not withdraw them. Isonics has the right, in its sole discretion, to extend
the expiration date of the exchange offer or offer withdrawal rights on a
case-by-case basis in the future.

CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE EXCHANGE

    The exchange of Class A Warrants for Class B Warrants will be treated as an
"exchange" for federal income tax purposes under the applicable provisions of
the Internal Revenue Code. We do not expect that holders who exchange their
Class A Warrants for Class B Warrants or who receive Class C Warrants following
exercise of their Class A Warrants will recognize any gain or loss.

    The exchange of Class A Warrants for Class B Warrants with terms identical,
except for the expiration date, to those of the Class A Warrants and the filing
of a registration statement with respect to the resale of the Class B Warrants
and Class C Warrants will not be a taxable event to holders of the warrants.
After the exchange, a holder's basis in the Class B Warrants or Class C Warrants
received in the exchange will be the same as the basis the holder had in the
securities surrendered in the exchange.

    The above discussion summarizes the expected tax effects of the exchange,
although there is no definitive guidance on point. The IRS could disagree with
the conclusions reached by Isonics. In the event of such disagreement, there is
no assurance that the IRS would not prevail in a judicial or administrative
proceeding. As a result of the complexity of the tax laws and the impact of each
holder's particular circumstances upon the tax consequences of the merger, the
information set forth above regarding the federal income tax consequences of the
merger is not intended to be individualized tax or legal advice to holders. Each
holder considering participation in the exchange offer should consult his or her
own tax or financial counsel as to the specific federal, state, and local tax
consequences of the exchange, if any, to such holder.

PARTICIPATION BY DIRECTORS AND OFFICERS IN THE EXCHANGE OFFER

    No directors or officers of Isonics beneficially own any Class A Warrants.

                                       17

ISSUANCE OF NEW CERTIFICATES

    Certificates representing Class B Warrants, and in some cases, Class C
Warrants will be delivered to participating holders as soon as practicable.

LOST CERTIFICATES

    If you have lost or misplaced your certificates representing Class A
Warrants or if they have been destroyed, contact the transfer agent for
additional information on the replacement and exchange of your Class A Warrants.
You may be required to provide an indemnity bond in connection with the
replacement of lost or destroyed certificates.

REQUESTS FOR ADDITIONAL INFORMATION

    If you have questions or require additional information concerning the
offering, please contact the following person at the address and telephone
number stated below:

    Brantley J. Halstead, Vice President--Finance
    Isonics Corporation
    5906 McIntyre Street
    Golden, CO 80403
    Telephone No.: (303) 279-7900
    Facsimile No.: (303) 279-7300
    e-mail: bhalstead@isonics.com

                                USE OF PROCEEDS

    Isonics will not receive any cash proceeds from the exchange of the Class A
Warrants, or the issuance of the Class B Warrants.

    Isonics will receive from $0.00 to a maximum of $4,698,000 from the exercise
of Class B Warrants (not including any securities issuable upon exercise of the
Underwriter Warrants).

    If all of the Class B Warrants are exercised (of which we can offer no
assurance), there will be 810,000 Class C Warrants outstanding. We will receive
from $0.00 to a maximum of $8,100,000 from the exercise of the Class C Warrants.

                                       18

                      MANAGEMENT'S DISCUSSION AND ANALYSIS
                  OF FINANCIAL CONDITION OR PLAN OF OPERATION

    THE STATEMENTS CONTAINED IN THIS PROSPECTUS THAT ARE NOT PURELY HISTORICAL
ARE FORWARD LOOKING STATEMENTS. "FORWARD LOOKING STATEMENTS" INCLUDE STATEMENTS
REGARDING OUR EXPECTATIONS, HOPES, INTENTIONS OR STRATEGIES REGARDING THE
FUTURE. FORWARD LOOKING STATEMENTS INCLUDE: STATEMENTS REGARDING FUTURE PRODUCTS
OR PRODUCT DEVELOPMENT; STATEMENTS REGARDING FUTURE SELLING, GENERAL AND
ADMINISTRATIVE COSTS AND RESEARCH AND DEVELOPMENT SPENDING AND OUR PRODUCT
DEVELOPMENT STRATEGY; STATEMENTS REGARDING FUTURE CAPITAL EXPENDITURES AND
FINANCING REQUIREMENTS; AND SIMILAR FORWARD LOOKING STATEMENTS. ALL
FORWARD-LOOKING STATEMENTS INCLUDED IN THIS DOCUMENT ARE BASED ON INFORMATION
AVAILABLE TO US ON THE DATE HEREOF, AND WE UNDERTAKE NO OBLIGATION TO UPDATE ANY
SUCH FORWARD-LOOKING STATEMENTS. IT IS IMPORTANT TO NOTE THAT OUR ACTUAL RESULTS
COULD DIFFER MATERIALLY FROM THOSE IN SUCH FORWARD-LOOKING STATEMENTS.

OVERVIEW

    Founded in 1992, Isonics Corporation is a specialty chemical and advanced
materials company, which develops and commercializes products based on stable
isotopes. Stable isotopes are ultra pure materials engineered at the molecular
level to provide enhanced performance properties in semiconductors, lasers and
high performance lighting, and energy production. Stable isotopes are also
widely used in basic research, pharmaceutical development and drug design, as
well as in medical diagnostics and imaging. By replacing materials traditionally
used in these industries with isotopically engineered versions of the same
materials, product performance, safety, and economics can be enhanced
significantly. Using state-of-the-art technology, we produce a wide range of
enriched stable isotopes, which are then converted into products, which meet the
specialized needs of our customers.

    Originally, our core business was the production and supply of depleted
zinc, a non-radioactive (or stable isotope), to the nuclear energy industry. In
fiscal 1996, we expanded our business scope to include development of
isotopically engineered materials for the medical research, medical diagnostic,
and semiconductor industries. The acquisition of Chemotrade GmbH ("Chemotrade")
in 1998 added radioactive isotopes (or radioisotopes) to our available products.
As a result of our sale of our depleted zinc business in December 1999, as
discussed below, our future revenues will depend on our success in developing
and selling products in the semiconductor and stable and radioactive isotope
markets.

    International Process Research Corporation ("Interpro", doing business as
Colorado Minerals Research Institute) is a contract research and development and
materials processing company and is developing new, lower cost technologies to
better meet our customers' needs. Interpro generates the majority of its
revenues from contract research and process development engagements.

    Chemotrade is headquartered in Dusseldorf, Germany, and its subsidiary is
located in Leipzig, Germany. Chemotrade is a value-added re-seller of stable and
radioactive isotopes. It supplies radioisotopes for pharmaceutical and
industrial research, as well as for industrial and medical imaging, calibration
sources and for brachytherapy applications. Chemotrade also distributes
calibration sources, manufactured by duPont with Chemotrade supplied
radioisotopes, in Germany and other European countries.

    Additionally, Chemotrade supplies various stable isotope labeled compounds
for pharmaceutical research and drug design, as well as oxygen-18 for use in
producing a radioisotope used in positron emission tomography. Chemotrade's
market is primarily Europe but sales are also made to North America and Asia.

    Prior to June 1998, substantially all of our net revenues in any particular
period were attributable to a limited number of customers and sales of depleted
zinc and other stable isotopes. We have historically operated with little
backlog. With the acquisition of Chemotrade we added radioisotopes to our
product mix, and consistent with our historical experience, our quarterly
results have been

                                       19

materially affected by the size, timing and quantity of orders and product
shipments during a given quarter.

    On December 1, 1999, we sold our depleted zinc business to Eagle-Picher
Technologies, LLC ("Eagle-Picher") for approximately $8,200,000 of which
$6,700,000 was paid on December 1, 1999. Additionally, we signed a long-term
isotope supply agreement with Eagle-Picher, and Eagle-Picher separately agreed
to supply us with 200 kilograms of silicon-28 in 2000 in exchange for a warrant
to purchase 4,000,000 shares issued at that time to Eagle-Picher. As a result,
we anticipate lower revenues in future quarters and a lost or delayed sale of
radioisotopes could have a significant impact on our operating results for a
particular period, and such fluctuations could materially and adversely affect
our business, financial condition and results of operations.

                             RESULTS OF OPERATIONS

    The following table sets forth, for the periods indicated, certain statement
of operations data expressed as a percentage of net revenues. The table and the
discussion below should be read in conjunction with the financial statements and
the notes thereto appearing elsewhere in this report.



                                                                                               NINE MONTHS
                                                                    YEAR ENDED                    ENDED
                                                                    APRIL 30,                  JANUARY 31,
                                                              ----------------------      ----------------------
                                                                1998          1999          1999          2000
                                                              --------      --------      --------      --------
                                                                                            
Net revenues................................................   100.0%        100.0%        100.0%        100.0%
Cost of revenues............................................    68.7          78.7          80.9          79.1
                                                               -----         -----         -----         -----
Gross margin................................................    31.3          21.3          19.1          20.9
Operating expenses:
  Selling, general and administrative.......................    19.8          21.4          17.1          28.0
  Research and development..................................    12.0           6.8           6.7           8.3
  Restructuring & office closure............................      --           4.1           4.9           0.5
                                                               -----         -----         -----         -----
Total operating expenses....................................    31.8          32.3          28.7          36.8
                                                               -----         -----         -----         -----
Operating income (loss).....................................    (0.5)        (11.0)         (9.6)        (15.9)
Other income (expense), net.................................    (2.1)         (2.8)         (1.3)         44.6
                                                               -----         -----         -----         -----
Income (loss) before extraordinary item and income taxes....    (2.6)        (13.8)        (10.9)         28.7
Income tax (expense) benefit................................     4.6          (1.0)          1.4           4.2
                                                               -----         -----         -----         -----
Income (loss) before extraordinary item.....................     2.0         (14.8)        (12.3)         24.5
Extraordinary item--loss on extinguishments of debt.........    (3.7)         (0.0)         (0.0)         (0.0)
                                                               -----         -----         -----         -----
Net income (loss)...........................................    (1.7)%       (14.8)%       (12.3)%        24.5%
                                                               =====         =====         =====         =====


                                  NET REVENUES

    Net revenues increased from $6,783,000 in fiscal 1998 to $16,998,000 in
fiscal 1999, an increase of $10,215,000 or 151%. The increase is primarily due
to additional net revenues from the Interpro and Chemotrade acquisitions.
Interpro 1999 revenues were $2,614,000. Chemotrade's fiscal 1999 revenue was
$10,181,000. As a result of the sale of the depleted zinc business to
Eagle-Picher on December 1, 1999, revenues will be decreased on an annual basis
by approximately $6,000,000. The impact on the fiscal year ended April 30, 2000,
should be somewhat less as the sale occurred seven months into the fiscal year.

    Net depleted zinc revenues for fiscal 1999 increased by approximately
$323,000 from fiscal 1998 revenues of $5,636,000, on comparable unit sales.
Average unit sales prices of depleted zinc decreased slightly from fiscal 1998
to fiscal 1999 due to less-refined product being sold during fiscal 1999. Net

                                       20

revenues for stable isotope labeled compounds (also known as "SILCs") in fiscal
1999 were approximately $2,599,000, an increase of approximately $1,492,000, or
135% from fiscal 1998. The revenue growth reflects the increasing demand for
SILCs, specifically enriched carbon and oxygen products; however, our revenue
from SILCs is limited by the available supply of enriched carbon and oxygen
products. We have and intend to continue to develop relationships with potential
producers of SILCs, such as the Institute of Stable Isotopes in Tblisi, Georgia,
to meet the growing demand for our SILC products.

    Net revenues for the nine months ended January 31, 2000, were $11,115,000, a
decrease of approximately 22% or $3,194,000 from $14,309,000 for the same period
in the prior fiscal year. The decrease is because our net revenues from contract
research and development engagements and other sources of sales decreased
approximately $1,301,000 for the nine months ended January 31, 2000, to
approximately $1,017,000 from approximately $2,318,000 in the comparable period
of the prior year. Net revenues from isotope product sales also decreased
approximately $1,893,000 for the nine months ended January 31, 2000, to
approximately $10,098,000 from approximately $11,991,000 in the comparable
period of the prior year. Net revenues from radioisotope sales decreased
approximately $513,000 for the nine months ended January 31, 2000, compared to
the nine months ended January 31, 1999, to approximately $5,001,000. Net
revenues from stable isotope sales decreased approximately $1,380,000 for the
nine months ended January 31, 2000, compared to the nine months ended
January 31, 1999, to approximately $5,097,000. Net revenues from stable isotopes
and radioisotope sales varied because of the timing and size of large depleted
zinc and radioisotope sales orders and shipments. Because of the Eagle-Picher
transaction there were no significant depleted zinc sales in the last two months
of the nine-month period ended January 31, 2000, and there will be no revenues
from the sale of depleted zinc for the remainder of the fiscal year ending
April 30, 2000.

    International sales represented approximately 60% of revenues in fiscal 1999
and less than 10% of net revenues for fiscal 1998. This substantial increase is
primarily attributable to our acquisition of Chemotrade.

    We do not anticipate significant revenues from sales of silicon-28 based
products in the fiscal year ended April 30, 2000. We are collaborating with
academia and industry to evaluate the benefits of isotopically pure silicon-28.
We believe that if evaluations demonstrate the commercial feasibility of one or
more products, demand could emerge in certain segments of the semiconductor
market. We can offer no assurance, however, that these evaluations will
demonstrate the commercial feasibility of any products, that we will be able to
commercialize any such products, or that a market will emerge for any such
products.

GROSS MARGIN

    As a result of the sale of the depleted zinc business to Eagle-Picher on
December 1, 1999, gross margin will be decreased on an annual basis by
approximately $1,000,000. The impact on the fiscal year ended April 30, 2000
should be somewhat less as the sale occurred seven months into the fiscal year.
As a percentage of revenues gross margin should not change significantly.

    Gross margin decreased to approximately 21.3% in fiscal 1999 from 31.3% in
fiscal 1998. The decrease is because of reduced unit sales prices of depleted
zinc, the increased proportion of net revenues generated from contract
manufacturing performed by Interpro, and stable and radioisotope revenues
generated by Chemotrade which typically have lower margins. Additionally, the
entrance to the oxygen-18 market has been achieved by pursuing market share over
margin. Gross margin for the nine months ended January 31, 2000, increased to
approximately 20.9% of net revenues from approximately 19.1% for the same period
in the prior fiscal year. The increase is primarily because of a change in
product mix sold during the nine month period as discussed above.

                                       21

SELLING, GENERAL AND ADMINISTRATIVE EXPENSES

    Selling, general and administrative expenses increased on a dollar basis by
approximately $2,300,000 to $3,600,000, or 21.4% of net revenues for fiscal 1999
from approximately $1,300,000 or 19.8% of net revenues for fiscal 1998. The
dollar increase in selling, general and administrative expenses is primarily
attributable to the acquisitions of Interpro and Chemotrade.

    As a result of the sale of the depleted zinc business to Eagle-Picher on
December 1, 1999, selling, general and administrative expenses will be decreased
on an annual basis by approximately $100,000. The impact on the fiscal year
ended April 30, 2000 should be somewhat less as the sale occurred seven months
into the fiscal year. We anticipate that, in general, selling, general and
administrative expenses will remain relatively stable because of cost controls
implemented throughout Isonics during the past twelve months. As a percentage of
revenues selling, general and administrative expenses should increase, as
revenues will be significantly lower.

    Selling, general and administrative expenses increased $673,000 or 27.5% to
approximately $3,117,000, or approximately 28.0% of net revenues for the nine
months ended January 31, 2000, from $2,444,000, or 17.1% of net revenues in the
comparable period of the prior year. The dollar increase for the nine months
ended January 31, 2000, was primarily attributable to increased usage of
professional services including legal, business development and accounting
services, and compensation expense related to bonuses paid to certain members of
senior management, because of profitability achieved in the quarter. The same
factors and lower revenues primarily caused the percentage increase.

RESEARCH AND DEVELOPMENT EXPENSES

    Research and development expenses increased by approximately $344,000 or
42.4% for fiscal 1999, while declining on a percentage basis to 6.8% of net
revenues in fiscal 1999, from 12.0% of net revenues in fiscal 1998. The dollar
increase during fiscal 1999 is primarily because of increased costs associated
with the development of isotopically pure silicon wafers and development costs
incurred at Interpro. The decrease in research and development expenses as a
percentage of net revenues from fiscal 1998 to fiscal 1999 was because of
revenue growth associated with our acquisitions. We believe that the development
and introduction of new product applications is critical to our future success
and expect that research and development expenses will remain stable (as
measured in dollars) in the near term because of the timing of material usage
and outside services, but may vary as a percentage of revenues.

    Research and development expenses will not be significantly affected by the
sale of the depleted zinc business to EaglePicher on December 1, 1999, because
we had not spent significantly funds on depleted zinc research and development
in the last fiscal year, and did not have plans for any significant future
research and development expenditures. However, as a percentage of revenues
research and development expenses should increase, as revenues will be
significantly lower.

    As described above, we signed a long-term isotope supply agreement with
Eagle-Picher, and Eagle-Picher is obligated to supply us with 200 kilograms of
silicon-28 in 2000. The silicon-28 will be used to further development of our
semiconductor materials business. The anticipated value of the 200 kilograms is
approximately $5,000,000. Since we purchased the 200 kilograms of silicon-28 by
issuing a warrant to Eagle-Picher to purchase 4,000,000 shares of stock, as we
use the silicon-28 we will recognize an expense of $25 per gram of silicon-28
received. This is the price we most recently paid for silicon-28 from another
supplier.

    Research and development expenses decreased by approximately $43,000, or
approximately 4.5%, to $919,000 for the nine months ended January 31, 2000, from
$962,000 for the comparable period in fiscal 1999, while increasing on a
percentage basis to approximately 8.3% of net revenues from approximately 6.7%.
The percentage increase during the nine months ended January 31, 2000, was

                                       22

primarily because of lower revenues as described above. The absolute dollar
expenditures are comparable year over year; however, more emphasis is now being
placed on semiconductor materials development.

    We believe that the development and introduction of new product applications
are critical to our future success and we expect that research and development
expenses will increase (as measured in dollars), in the near term because of the
timing of material usage and outside services, but will likely continue to vary
as a percentage of revenues because of the timing and amount of future revenues.

RESTRUCTURING AND OFFICE CLOSURE

    On October 31, 1998, we announced a restructuring of our operation and
relocation of our headquarters to Golden, Colorado, the location of our
subsidiary, Interpro. We originally recorded a $708,000 charge in connection
with the restructuring.

    As of January 31, 2000, the only significant restructuring cost remaining is
the lease payments on the former San Jose, California office, which has been
sublet for the remaining term of our lease. The net liability is estimated to be
approximately $51,000 and will be incurred over the next four years. The $60,000
expense in the nine months ending January 31, 2000, was primarily related to
moving costs incurred by two senior executives.

OTHER INCOME (EXPENSE), NET

    Other income (expense), net includes interest income and expense,
amortization of debt issuance costs and the fair value of warrants issued in
connection with debt, and foreign currency gains and losses. Other expense, net
increased by approximately $339,000 to $484,000 for fiscal 1999. The increase
was the result of foreign currency gains from liabilities denominated in German
Deutsche Marks due to the sellers of Chemotrade which was offset by a
significant increase in interest expense including charges for the fair value of
warrants and common shares issued in connection with debt and debt conversions.
Other income (expense), net increased by approximately $5,142,000, to
$4,962,000, for the nine months ended January 31, 2000, from other income
(expense), net of approximately $(180,000), for the comparable period of the
previous fiscal year. The Eagle-Picher transaction resulted in $5,172,000 in
other income. Additionally, an increase in other income of approximately
$112,000 was due to a favorable settlement of an outstanding contingency.
Foreign currency exchange losses increased by approximately $99,000 for the nine
months ended January 31, 2000.

    Interest expense is expected to be significantly lower in future periods as
several notes payable were paid with a portion of the cash proceeds received
from the sale of the depleted zinc business to Eagle-Picher on December 1, 1999.

INCOME TAXES

    The income tax benefit was $314,000 for fiscal 1998 and the effective rate
of 177% relates to the realization of deferred tax assets associated with the
purchase of Interpro and the reduction of the previously recorded valuation
allowance. The consolidated entity had an income tax expense of $171,000 for
fiscal 1999. Because the Chemotrade subsidiary had net income, income taxes were
paid in Germany. The two United States-based entities both had net losses and
did not owe income taxes. A valuation allowance has been provided against all
deferred tax assets, which relate primarily to net operating loss and research
and development credit carryforwards. We are exploring various tax minimization
strategies in an effort to conserve future cash flows.

    We realized a gain on the sale of our depleted zinc business of
approximately $5,172,000. The tax effect of this sale, net of tax loss
carryforwards available is estimated to be approximately $435,000. Additionally,
there was income tax expense for the quarters ended January 31, 2000, and
January 31,

                                       23

1999, of $35,000 and $177,000 respectively, and income tax expense for the nine
months ended January 31, 2000 and 1999, of $36,000 and $197,000 respectively
related to income generated by our Germany-based subsidiary, Chemotrade.

LIQUIDITY AND CAPITAL RESOURCES

    As a result of the sale of the depleted zinc business to Eagle-Picher on
December 1, 1999, our liquidity has been significantly improved.

    Since inception, our principal sources of funding have been cash from
operations, borrowed funds and sales of Common Stock. We generated cash in
operating activities of approximately $357,000 during fiscal 1999, as compared
to a use of cash of $539,000 in fiscal 1998. During the nine months ended
January 31, 2000, we used approximately $2,904,000 in operating activities, as
compared to $146,000 generated in operating activities during the first nine
months of fiscal year 1999.

    Positive influences on fiscal 1999 cash flow included

    - a decrease in accounts receivable of $1,748,000;

    - non-cash charges for depreciation and amortization expense of $520,000;
      and

    - non-cash charges for the loss on disposal of property (restructuring
      related) of $504,000.

    In addition to the net loss of $2,521,000 we recognized for fiscal year
1999, other negative influences on our cash flow from operations were a decrease
in accounts payable $112,000 and an increase in inventory of $89,000.

    At April 30, 1999, we had approximately $452,000 of cash equivalents, a
decrease of $592,000 compared to $1,044,000 at April 30, 1998. At April 30,
1999, we had negative working capital of approximately $2,317,000, a decrease of
$4,128,000 compared to working capital of $1,811,000 at April 30, 1998. The
decrease is primarily the result of our cash payments for the acquisition of
Chemotrade and the losses incurred for fiscal 1999. During fiscal 1999, we paid
the sellers of Chemotrade approximately $1,686,000 in cash, and had one note for
approximately $826,000 outstanding due to the sellers on June 1, 1999, of which
approximately $500,000 was repaid and approximately $326,000 was extended until
July 2000 and has been subsequently repaid.

    At January 31, 2000, we had approximately $4,576,000 of cash and cash
equivalents, an increase of approximately $4,124,000, compared to $452,000 as of
April 30, 1999. At January 31, 2000, we had positive working capital of
approximately $4,067,000, an increase of approximately $6,384,000 from negative
working capital of approximately $2,317,000 April 30, 1999. The increase is
primarily the result of proceeds from the issuance of preferred stock in
July 1999 and the Eagle-Picher transaction.

    Our principal sources of funding have been cash from borrowed funds and
sales of preferred stock. We used cash in operating activities of approximately
$2,904,000 and generated cash of $146,000, during the nine months ended
January 31, 2000, and 1999, respectively. Cash used in operating activities
during the nine months ended January 31, 2000 was principally the result of a
net loss of approximately $2,454,000 before the gain of approximately $5,172,000
resulting from the Eagle-Picher Transaction, and increase in net operating
assets. Cash generated by operating activities during the nine months ended
January 31, 1999, was principally the result of a net loss of $1,757,000,
reduced by non-cash charges and decreases in net operating assets.

    Financing activities used cash of $244,000 in fiscal 1999, and provided cash
of $1,621,000 during fiscal 1998. Financing activities generated cash of
$318,000 during the nine months ended January 31, 2000 and used cash of $296,000
during the comparable period of the prior fiscal year. In fiscal 1999, the
primary use of cash was the excess of repayments of debt, $1,000,000 over
proceeds of debt, $701,000. In fiscal 1998, the primary source of cash was the
issuance of Common Stock, $3,452,000

                                       24

versus the use of cash for payments of debt, $1,852,000. During the nine months
ending January 31, 2000, our principal source of cash from financing activities
was the issuance of convertible preferred stock in July 1999 for cash of
$2,250,000 and proceeds from the issuance of long-term debt of $75,000. Net
repayments on our revolving line of credit amounted to $513,000 during the
nine-month period, and we repaid additional debt during that period of
approximately $1,494,000, each resulting in a reduction in the net amount of
cash received from financing activities. Cash used during the nine months ended
January 31, 1999, resulted primarily from repayments of debt of $1,714,000,
offset by net borrowings on the revolving line of credit of $931,000 and
proceeds of $500,000 from the issuance of long-term debt.

    On July 29, 1999, we completed a private placement financing to accredited
investors and certain creditors valued in total at approximately $2,700,000. We
issued 1,830,000 units, each consisting of one share of Series A Convertible
Preferred Stock and one warrant. We received $2,250,000 in cash proceeds and
converted $425,000 of long-term debt in connection with the private placement.
Each share of the Series A Convertible Preferred Stock is convertible into one
share of our Common Stock at a conversion price of $1.50. The liquidation
preference for the Series A Convertible Preferred Stock is $1.50. Each warrant
allows the investor to purchase one share of Isonics Common Stock for $3.75
through July 29, 2002. We granted certain registration rights to the holders of
the shares of common stock underlying the Class A Convertible Preferred Stock
and the warrants.

    In addition to converting $425,000 of existing debt into equity as part of
the private placement we:

    - Issued 500,000 warrants to purchase shares of our Common Stock to an
      investment banker as a commission on this placement. The warrants are
      exercisable at $3.75 per share through July 29, 2002.

    - Issued 46,667 units in satisfaction of all current and future obligations
      under the Isoserve royalty agreement.

    - Extended the payment due date for the remaining balance on the Chemotrade
      acquisition note to July 2000.

    - Extended the payment due date for certain unsecured promissory notes to
      January 2000, which notes have been paid in full.

    Our investing activities used cash of approximately $705,000 and $66,000
during fiscal 1999 and 1998, respectively, and generated cash of approximately
$6,710,000 for the nine months ended January 31, 2000. Investing activities in
fiscal 1998 were primarily for purchases of property and equipment. Uses of cash
in fiscal 1999, include approximately $159,000 for property and equipment, and
$546,000 net cash used in the Chemotrade acquisition. The significant positive
cash flow from investing activities in the first nine months of fiscal 2000 was
principally the result of the completion of the Eagle-Picher transaction. Our
investing activities used cash of $666,000 for the nine months ended
January 31, 1999, primarily for purchases of property and equipment and $546,000
was also used during the nine months ended January 31, 1999 for the purchase of
our subsidiary Chemotrade.

    On July 24, 1998, we obtained a $3,000,000 asset based credit facility for
our U.S. operations, secured by our U.S. assets, with an unaffiliated lender.
This facility was repaid, in full, in December 1999 with funds made available by
our sale of assets to Eagle-Picher. The proceeds of that facility were used to
repay approximately $537,000 of debt outstanding and $742,000 of accounts
payable. Chemotrade has one unsecured revolving line of credit for 400,000 DM
(approximately $220,000 (US) at April 30, 1999 and approximately $200,000 (US)
at January 31, 2000). We are evaluating alternative secured credit facilities
for Chemotrade.

    At April 30, 1999, and subsequently until December 1, 1999, we were in
default of our borrowing agreements with Coast Business Credit ("Coast"), and on
December 1, 1999, we had approximately

                                       25

$215,000 of outstanding borrowings. We have used some of the proceeds of the
depleted zinc business sale described above to pay off the Coast borrowings and
our relationship with Coast has been terminated. We believe that our current
cash position, attributable to the proceeds received from the sale of our
depleted zinc business and the reduced levels of debt associated therewith, will
be sufficient to fund operations for more than the next twelve months. However,
our long-term capital requirements will only be met if we are able to generate
profits from operations and positive cash flows, or develop new sources of
financing of which there can be no assurance.

                                       26

                                    BUSINESS

    Isonics Corporation is an advanced materials and technology company which
develops and commercializes products based on enriched stable isotopes. Stable
isotopes can be thought of as extremely pure materials. This high degree of
purification accomplished on the sub-atomic level provides enhanced performance
properties compared to normal purity materials. Stable isotopes have commercial
uses in several areas, including: energy; medical research, diagnostics and drug
development; product tagging and stewardship; semiconductors; and optical
materials. We have successfully developed and commercialized several isotope
products and intend to promote the emergence and growth of new stable isotope
applications.

    Our principal product through November 1999 was isotopically depleted zinc.
Depleted zinc is used to prevent corrosion in nuclear power plants. Corrosion is
a cause of high radiation fields in such plants and can result in radiation
exposure to workers. Depleted zinc also reduces environmental cracking in
certain kinds of nuclear reactors, which if not controlled, can require
extremely costly repairs, or possibly result in premature shutdown and
de-commissioning of the facility. However, in December 1999, we sold our
depleted zinc business to Eagle-Picher Technologies, LLC.

    New applications for stable isotopes are continually being developed by us
and by third parties. We believe that new applications have the potential to
create new markets. One of these new applications for stable isotope labeled
compounds is the diagnostic breath test ("DBT") market. DBTs provide early
diagnosis of conditions that could otherwise lead to expensive procedures such
as endoscopies and biopsies. DBTs under development by third parties that
utilize stable isotopes in their application include tests to diagnose peptic
ulcers, gastric emptying, fat malabsorption and liver function. Two DBTs,
relating to peptic ulcers, have been approved by the U.S. Food and Drug
Administration (the "FDA"). We believe that other companies have applied to the
FDA or comparable agencies in foreign countries for approval of these and other
tests. FDA approval must be obtained before DBTs can be sold in the United
States.

    The rare, stable isotope of carbon is carbon-13. Carbon-13 is the key
ingredient for most DBTs. We believe that we are the third largest supplier of
carbon-13 in the world, and are the only non-Japanese owned supplier. To further
strengthen this position, in February 1998, we formed a joint venture with the
Institute of Stable Isotopes in Tblisi, Georgia. The purpose of the joint
venture was to increase carbon-13 production at the Institute initially, and
then to transfer that production technology to manufacturing facilities to be
established in Europe and North America. Our carbon-13 production capacity does
not presently meet our anticipated requirements. Consequently, in
December 1999, we entered into an agreement with Eagle-Picher Technologies, LLC,
to purchase carbon-13 from their Oklahoma-based facility. To date this facility
has not produced any carbon-13, or other carbon isotopes of sufficient
enrichment to be of commercial interest to us. We believe production of enriched
carbon isotopes from this facility will commence in 2000. We are also
investigating other sources of supply of carbon-13.

    We are collaborating with academia and industry to evaluate the benefits of
isotopically pure silicon-28. One of the properties of isotopically pure
silicon-28 is its high thermal conductivity, which we are currently researching
for use in semiconductor applications. We believe that if evaluations
demonstrate the commercial feasibility of one or more products, demand could
emerge in certain segments of the semiconductor market. We can offer no
assurance, however, that these evaluations will demonstrate the commercial
feasibility of any products, that we will be able to commercialize any such
products, or that a market will emerge for any such products. According to the
Semiconductor Industry Association, sales in 1998 of silicon wafers and other
semiconductor substrates were over $7 billion.

    Improved thermal conductivity of a thin film of isotopically pure silicon-28
was demonstrated by a researcher at Brown University in 1997. Based on our
preliminary research, the 60% improvement in conductivity at room temperature
was in line with our expectations. Since 1994, we have been working

                                       27

to produce isotopically pure silicon-28 epitaxial wafers suitable for the
manufacture of semiconductor devices. Epitaxial wafers are made by taking an
existing silicon wafer and then growing a thin surface layer of silicon using
chemical vapor deposition.

    In fiscal 1999, we acquired an exclusive license relating to two Yale
University patents, which cover semiconductor devices made of isotopically pure
silicon, germanium, gallium arsenide and most isotopically pure compound
semiconductors. The patents claim that isotopic purity provides improved device
speed and improved thermal conductivity, two properties that are of great
importance to the semiconductor industry. We believe we have achieved this goal
as evidenced by our shipments of epitaxial wafers in fiscal 1999.

    We were formed in March 1992, as a partnership, and were subsequently
incorporated in California in March 1993, as A&R Materials, Inc. In
September 1996, we changed our name to Isonics Corporation. Our principal
executive offices are located at 5906 McIntyre Street, Golden, Colorado 80403.
Our telephone number is (303) 279-7900, and our facsimile number is
(303) 279-7300. You can find our web site at http://www.isonics.com.

RECENT BUSINESS ACQUISITIONS

    INTERNATIONAL PROCESS RESEARCH CORPORATION

    Effective April 30, 1998, we purchased all of the outstanding capital stock
of International Process Research Corporation ("Interpro") from a previously
unaffiliated corporation (Metallurgy International, Inc.) Interpro, which does
business as Colorado Minerals Research Institute, is a contract research and
development, and materials processing company. Interpro performed (through
December 1, 1999) key steps in our depleted zinc manufacturing process. Interpro
is also jointly developing new, lower-cost technologies to enable us to better
meet customer needs. The acquisition was made to assure future availability of
this critical manufacturing technology, and to provide an infrastructure
platform for performing value-added processing of other isotopes. Our
consolidated balance sheets at April 30, 1999 and 1998 include the assets and
liabilities of Interpro. Our consolidated statement of operations includes
Interpro only for fiscal 1999 since the acquisition occurred on the last day of
fiscal 1998. In connection with the acquisition, we issued 353,982 shares of our
Common Stock (valued at $708,000) in exchange for all of the outstanding shares
of Interpro. We accounted for the acquisition as a purchase.

    CHEMOTRADE GMBH

    Effective June 1, 1998, we acquired all of the outstanding shares of
Chemotrade GmbH, 75% of the outstanding shares of Chemotrade Leipzig GmbH and 6%
of the outstanding shares of IUT (collectively "Chemotrade"). All three
companies are located in Germany. Chemotrade GmbH is located in Dusseldorf,
Chemotrade Leipzig GmbH is located in Leipzig, and IUT is located in Berlin. All
three companies were owned by two common shareholders. All three companies
continue to be engaged in the distribution, development and manufacture, of
stable and radioactive isotopes. We paid the unaffiliated former owners of
Chemotrade $758,000 in cash, 357,730 restricted shares of our Common Stock
valued at $894,000, and two interest bearing notes, one for $924,000 which was
paid in September 1998, and a second note for $826,000 which was partially paid
in June 1999, with the balance due in July 2000.

    The sellers guaranteed Chemotrade's defined pre-tax earnings during the
sixteen months ended April 30, 1999, and the twelve months ended April 30, 2000,
and 2001. Chemotrade met the initial pre-tax earnings goal for the sixteen
months ended April 30, 1999. If the defined pre-tax earnings for 2000 and 2001
are met, the sellers will receive additional consideration of $271,000. If the
defined pre-tax earnings are not met, the consideration will be reduced.

                                       28

BUSINESS THAT WE SOLD

    On December 1, 1999, we sold our depleted zinc business to Eagle-Picher
Technologies, LLC ("Eagle-Picher") for $8,200,000, including $1,500,000 to be
paid over a period of three years. Eagle-Picher's obligation to pay the final
$1,500,000 is subject to certain contingencies. We received cash of
approximately $6,700,000 from Eagle-Picher at the closing, of which
approximately $1,200,000 was used to pay certain accrued liabilities.

    The Agreement executed between us and Eagle-Picher provides for:

    (1) Our sale of the depleted zinc business to Eagle-Picher for a purchase
       price including approximately $6,700,000 in cash plus three additional
       payments of $500,000 over the next three years, and

    (2) Eagle-Picher's sale to us of 200 kilograms of silicon-28 in
       consideration for a forty-two (42) month Warrant grant to Eagle-Picher
       for the purchase of 4,000,000 shares of our Common Stock at purchase
       price of $3.75 per share. The Warrant is subject to a registration rights
       agreement. The number of shares issuable upon exercise of the Warrant can
       be reduced if Eagle-Picher is unable to supply the full 200 kilograms of
       silicon-28 during calendar year 2000. Eagle-Picher exercised the warrants
       in March 2000 under a "net-exercise' provision entitling it to receive
       3,130,435 shares of common stock. These shares are subject to reduction
       to the extent Eagle-Picher does not deliver the required 200 kilograms.
       Eagle-Picher claims that we should issue it an additional 155,279 shares
       pursuant to the net exercise provision, but we believe its calculation is
       in error, and we are continuing discussions with representatives of
       Eagle-Picher.

    Related to, but separate from, the sale of the depleted zinc business and
the purchase of the 200 kilograms of silicon-28, we contemporaneously signed a
ten-year Supply Agreement by which we will have the exclusive right to purchase
quantities of isotopically pure silicon-28, silicon-29, and silicon-30, and a
non-exclusive right to purchase quantities of isotopically pure carbon-12 and
carbon-13 produced by Eagle-Picher from its Oklahoma-based facilities. The
Supply Agreement locks-in what we believe is a favorable purchase price for the
aforementioned isotopes. As partial consideration for the exclusivity provision,
we agreed to pay Eagle-Picher a fee equal to 3.0% of the net revenues from all
sales made by us of products incorporating enriched silicon isotopes supplied by
Eagle-Picher.

BACKGROUND

    An isotope is one of two or more species of the same chemical element, which
differ from one another only in the number of neutrons in the nucleus of the
atom. The different number of neutrons can create significantly different
nuclear physics characteristics. To take advantage of some of these different
characteristics, it is usually necessary to increase ("enrich") or decrease
("deplete") the concentration of a particular isotope. There are over 280
naturally occurring stable isotopes of 83 elements. Some elements have only one
naturally occurring stable isotope, while others have many. Stable isotopes are
not radioactive.

    Stable isotopes of an element differ in mass and diameter, as well as
several nuclear properties, such as cross-section, spin and magnetic moment.
Differences in these properties can result in substantially different effects,
and some of these differences have the potential for commercial application. For
example, in ultra chemically pure crystals grown for electronics or optical
applications, isotopic impurities are the greatest contributor to crystal
disorder because of mass and diameter variations. Eliminating this disorder by
using a single enriched isotope (i.e. isotopically pure substance) results in
increased thermal conductivity and optical transparency, and thus in improved
product performance. Similarly, enriching or depleting isotopes based upon their
cross-sections allows materials to be engineered for applications in the nuclear
power industry, for controlled doping of some

                                       29

semiconductors in the computer industry, and for use as targets to produce
radioisotopes for the medical and other industries.

    Stable isotopes of an element do not differ significantly in their chemical
behavior. By varying the natural abundance of isotopes present in the material
it can be "Tagged". Varying the natural abundance gives a material its own
unique mass or nuclear magnetic signature. Most importantly, tagging in this
manner does not change a given material's chemical properties. Though chemically
equivalent, the "tagged" or labeled material is discernible from its unlabeled
twin through the use of several types of instruments called spectrometers.

COMPANY STRATEGY

    We believe that our strength is the ability to bring the necessary
ingredients together to identify, evaluate, develop, engineer, and successfully
commercialize applications for stable isotopes and value-added products
manufactured from stable isotopes. This is evidenced by management's experience
(at Isonics and in prior employment) in developing depleted zinc from what was
initially a cost prohibitive concept to a commercial product. The worldwide
market for depleted zinc is now one of the largest for a stable isotope product.

    We believe we have created a product development model that can serve as a
basis for our current and future expansion. To capitalize on the commercial
opportunities that have been identified for stable isotopes, we have adopted a
business strategy designed to maximize the value of our technologies, business
development and management resources, while attempting to minimize capital
costs. This strategy involves:

    - focusing on development of high value-added products, which have a
      competitive advantage in large or growing markets;

    - leveraging research and development expenditures through collaborations,
      government programs and corporate partnerships;

    - minimizing early capital needs by obtaining stable isotopes through
      alliances and supply agreements with existing stable isotope sources,
      followed by investment in company-owned isotope production facilities when
      markets are more established and the optimum production technology has
      been determined;

    - obtaining value-added processing technology through sub-contract
      manufacturing agreements, joint ventures and acquisitions of strategically
      important technologies and companies; and

    - developing a time-balanced product pipeline to provide a continual supply
      of new business opportunities.

    PRODUCTS.  Depleted zinc sales have historically been our most significant
source of revenues. However, in fiscal 1999, our revenues were generated from a
more broad range of sources, including depleted zinc sales (approximately 35%),
radioisotopes sales (approximately 34%), and other stable isotopes sales
including our newly introduced silicon-28 isotope (approximately 15%). The
balance of our revenues comes from the operations of our subsidiary,
International Process Research Corporation (approximately 16%), who performs
metallurgical and mineral processing contract research and process analysis test
work. Because we sold our depleted zinc business in December 1999, depleted zinc
will continue to be a significant contributor to our revenues from operations in
fiscal 2000, however depleted zinc sales will cease to be a significant
contributor to our revenues in subsequent fiscal years.

    RADIOISOTOPES.  With the acquisition of Chemotrade GmbH in Germany, we have
expanded our product offerings to include radioisotopes produced at several
facilities in Russia and Uzbekistan. Radioisotopes are radioactive. These
products are sold to us under territory-specific, exclusive distribution
agreements with the licensed representatives of the production facilities.
Extensive export

                                       30

controls effectively restrict the flow of these products to well-defined
channels, limiting the price competition more commonly observed with some stable
isotope products from countries that once were part of the former Soviet Union.
Sales of these products represented 34% of net revenues in fiscal 1999.

    Radioisotopes are used in fields as diverse as basic physics, biomedical
research, medical imaging and therapy, radioactive waste management technology
development, and inspection/verification technologies. Several of these market
segments are already experiencing strong growth, and with additional
radioisotope-based products in various stages of development and regulatory
approval, promise significant potential for further growth. Examples of existing
and emerging applications follow.

    BIOMEDICAL RESEARCH.  Traditionally, numerous aspects of the many phases of
drug development have been carried out using radioisotope-labeled versions of
promising compounds. Metabolism, distribution, mode of action and elimination of
candidate drug compounds can be studied with the radioisotopes of hydrogen,
carbon, and phosphorus, among others. We have been supplying several precursor
compounds labeled with carbon-14 to a major manufacturer who incorporates them
into more complex radioisotope labeled compounds for use in basic research and
pharmaceutical development. The precursors are produced under contract with a
company in which we hold a small minority share. While rational drug design and
stable isotope labeled compounds represent competition for this more traditional
approach to research and drug development, we believe a combination of
increasing drug development activity and the large body of data and experience
will ensure a strong market for these products.

    MEDICAL IMAGING AND THERAPY.  Radioisotopes have been used for years in the
diagnosis and treatment of many medical conditions in humans. The trend in these
two areas has been towards increasingly more specific chemicals which, after
labeling with the radioisotope and introduced into the patient, quickly
concentrate at the site of interest. In theory, the appropriate choice of
chemical and radioisotope labels would allow disease detection and determination
of extent, followed by therapy selection, administration and monitoring. Several
classes of chemical compounds ranging from monoclonal antibodies to peptides,
most recently, are being developed, tested and approved for use in the
detection, and eventually, the treatment of many disease states. While certain
isotopes will remain the dominant radioisotopes for imaging and therapy
monitoring, they typically have no role in therapy. We believe that with the
increased supply of new radioisotopes and the ongoing development of highly
specific biochemical therapies, this market segment represents a major growth
opportunity.

    BRACHYTHERAPY.  Cancer therapy continues to evolve to more effectively
target the many different types of cancer. The radioisotope labeled compounds
mentioned above promise great advances in focused treatment, but are still well
in the future. Today, external beam radiotherapy and chemotherapy are the
predominant technologies used in cancer treatment, but another technology,
brachytherapy, is emerging in the treatment of specific disease states like
prostate cancer. In this technique, small sealed sources are inserted directly
into the tumor using a variety of minimally invasive surgical methods. The
radioisotope is chosen to ensure that only the tissue immediately adjacent to
the implanted seed is irradiated; this avoids irradiating nearby healthy tissue
as occurs with external beam radiotherapy. Several companies (Theragenics, North
American Scientific, International Isotopes, etc.) already offer or have
announced plans to offer brachytherapy products for the treatment of certain
forms of prostate cancer. Studies continue in the application of this technique
for other tumor types, including some breast cancers. We currently supply
several companies with radioisotopes for this application. We believe this
market segment represents one of the largest growth opportunities for
radioisotopes.

    Another form of brachytherapy involves the temporary introduction of a
sealed and shielded source of radioisotope into the body to deliver a localized,
high dose irradiation of tissue. One of the applications being evaluated is for
irradiation of vessel walls immediately following balloon angioplasty

                                       31

to reduce the occurrence of restenosis. We believe this application and others
like it will take several years to develop, but they represent interesting and
promising new opportunities for radioisotopes.

    INDUSTRIAL APPLICATIONS.  Numerous industrial applications require
radioactive materials. One of the largest uses is in radioactive source
standards. These are employed as calibration tools for numerous radiation
detectors, with one of the largest group of users being the Nuclear Medicine
departments in the thousands of hospitals throughout the world. We supply many
isotopes used in the manufacture of these sources and distribute the finished
products of one of these manufacturers in parts of Europe. The continued growth
in the numbers and complexity of nuclear medicine imaging equipment, especially
PET (positron emission tomography), should ensure growth in the demand for these
radioisotopes.

    STABLE ISOTOPE LABELED COMPOUNDS.  Stable isotope labeled compounds (known
as "SILCs") are created by incorporating carbon, nitrogen, hydrogen, and oxygen
isotopes into several thousand relevant chemical compounds. Sales of SILCs
represented approximately 15% and 16% of our net revenues in fiscal 1999 and
1998 and, because of the sale of our depleted zinc business, we expect this
percentage to increase in and after fiscal 2000. SILCs allow researchers to
probe the metabolism of living systems, determine the structures of important
biological compounds, design new drugs and measure extremely low levels of
environmental toxins. We believe that greater availability of stable isotopes
and advances in instrumentation (improvements in sensitivity and reduced cost)
will promote increased demand for SILCs. We have expanded our ability to acquire
some of these isotopes as a result of the Supply Agreement we entered into with
Eagle-Picher. If Eagle-Picher is able to produce enriched carbon isotopes from
its facilities in Oklahoma, we will have expanded our supply of these isotopes
and we will no longer be solely dependent on facilities in the former Soviet
Union as suppliers of these isotopes. Examples of existing and emerging
applications include:

    METABOLIC STUDIES.  Increasingly, drug studies are performed with labeled
drugs to facilitate research on metabolism, distribution, mode of action, and
elimination. The FDA may eventually mandate the labeling of all new drugs for
investigational use during some or all phases of pre-clinical and clinical
evaluations of these drugs, but there can be no assurance that the FDA will make
this mandate in the near future, if at all.

    RATIONAL DRUG DESIGN.  Nuclear magnetic resonance ("NMR") spectroscopy is
being developed as a tool to determine the structure of larger and larger
molecules in solution, many of which cannot be analyzed by the more traditional
x-ray crystallography techniques. We believe that this new NMR sensitivity,
combined with the sophisticated isotopically labeled cell growth media needed to
produce the labeled human proteins, will require an increasing supply of the
stable isotopes of carbon, nitrogen, and deuterium.

    PRODUCT TAGGING AND STEWARDSHIP APPLICATIONS.  The source of materials and
explosives may be identified, without changing their chemistry, by tagging with
the stable isotopes of carbon, nitrogen, oxygen, and hydrogen. Several other
approaches are currently being implemented, and other technologies have also
been proposed. These other approaches involve the addition of extraneous
materials such as dyes, exotic chemical compounds or radioactive compounds. We
believe that adding such extraneous materials can sometimes detract from the
performance of the product. Tagging with small amounts of isotopically
engineered versions of the material itself results in a unique identifier that
behaves chemically in exactly the same way as the host material.

    Our efforts to date in the production and sales of SILCs have focused on
structurally simple "building block" compounds which are used by our customers
to synthesize more complex and higher value SILCs. We market carbon-13 and
nitrogen-15 building block SILCs, which we obtain through our supply alliance
with several stable isotope producers. In the near term, we will continue this
strategy of

                                       32

supplying "building block" forms of stable isotopes while at the same time
increasing our production capacity both at our alliance producers and our
facilities.

    In addition to providing additional revenue potential and possibly higher
margins, we believe that developing or acquiring complex SILC synthesis
capability would be synergistic with our efforts to develop the breath test
diagnostics product area, and would also aid in early identification of future
stable isotope business opportunities.

    DIAGNOSTIC BREATH TESTS.  Healthcare consumes a large amount of resources in
the United States and worldwide. We believe that substantial changes are taking
place to control or reduce the high cost of healthcare. A significant trend is a
general shift from therapy to cost-effective prevention. Early diagnosis of
conditions which otherwise could require expensive therapies could help diminish
the risks and expense of such subsequent procedures. We have elected to pursue
what we believe is a promising segment of this market: diagnostic breath tests
("DBTs").

    Breath tests are all based on the same principle and use a common instrument
to measure the result:

    - a small amount of a carbon-13 SILC (referred to as a substrate) is
      swallowed by the patient;

    - breath samples are collected at regular intervals; and

    - breath samples are analyzed for their carbon-13 content.

    Most DBTs are intended to replace unpleasant, costly and sometimes risky
procedures such as endoscopies and biopsies of the digestive system. We believe
that DBTs may become a widely used and accepted diagnostic tool. Certain DBTs
are currently being sold in the U.S. and in Europe. Their ease of administration
may allow medical internists and general practitioners to use them, potentially
resulting in lower cost, earlier diagnosis, and broader application.

    The market for DBTs is defined by the incidence of diseases addressed, and
existing, alternative diagnostic procedures. The urea breath test is the most
established DBT. As they become more widely available, carbon-13 urea breath
tests ("UBTs") may address a potential population of approximately 8,000,000
peptic ulcer patients in the U.S., who presently utilize drugs and procedures
with an estimated cost of at least $2 billion each year. We believe that the
UBT, coupled with antibiotic treatment, can reduce the cost of peptic ulcer
management. Two companies in the U.S. have received FDA approval for a carbon-13
UBT. We believe that several companies in Europe have received regulatory
approval.

    The following table identifies additional breath tests, which are at various
stages of clinical research and pre-clinical and clinical trials by various
third parties.



          BREATH TEST                           CONDITION DIAGNOSED
- -------------------------------  -------------------------------------------------
                              
(13)C-Urea                       Helicobacter pylori
(13)C-Triolein                   Fat malabsorption
(13)C-Spirulina                  Gastric emptying
(13)C-Galactose                  Liver function
(13)C-Xylose                     Small Bowel Bacterial Overgrowth (the major cause
                                 of chronic diarrhea)
(13)C-Aminopyrine                Liver function
(13)C-Caffeine                   Liver function
(13)C-Erythromycin               Cyclosporin dosage following transplantation
(13)C-Valine                     Genotype of MSUD (Maple Syrup Urine Disease)
(13)C-Sucrose                    Sucrose malabsorption (sucrase-isomaltase complex
                                 deficiency)
(13)C-Starch                     Pancreas amylase function
(13)C-Cholesteryl Octanoate      Pancreas esterase function


                                       33

    We have entered this market supplying carbon-13 to manufacturers. We are
considering the possibility of manufacturing pharmaceutical-grade substrates
sometime in the future. We purchase carbon-13 from the Institute of Stable
Isotopes located in Tblisi, Georgia. This institute was the center of
development of technology for light isotope separation in the former Soviet
Union.

    We are investigating the feasibility of building such plants and are
considering various strategic options, such as partnering or acquisition of
complementary technologies or businesses, to leverage our carbon-13 production
capability. One such effort is the Supply Agreement we negotiated with Eagle-
Picher for the supply of various isotopes including carbon-13 as described
above.

    The DBT business is subject to extensive government regulation. The products
and instruments used, which may be regulated as drugs and devices, are subject
to the scrutiny of FDA review and approval as well as ongoing FDA inspection of
most aspects of the production, marketing, distribution and use of these tests.
We believe that the production and marketing of DBTs are also subject to similar
regulatory controls in the foreign countries where we would likely seek to
market products. Consequently, such products cannot be commercially introduced
for several years, and there can be no assurance that the products would ever be
approved for use.

    MEDICAL IMAGING AND THERAPY MATERIALS.  Stable isotopes of thallium, zinc,
cadmium, xenon, oxygen, strontium, and many others are routinely used in a
variety of medical imaging and therapy applications. In their enriched form or
converted to a specific radioactive isotope in a cyclotron or nuclear reactor,
these materials are incorporated in chemical compounds which concentrate in
specific parts of the human body upon injection, inhalation, or ingestion.
Measuring the distribution of the materials in the patient can assist physicians
in diagnosing disease states and developing appropriate treatment therapies,
some of which incorporate radioactive materials produced from stable isotopes.

    We have decided to pursue one particular target isotope, oxygen-18, used to
produce fluorine-18, which is incorporated into the pseudo-sugar, FDG, and used
in Nuclear Medicine to diagnose multiple metabolic abnormalities. Approvals by
the FDA, favorable reimbursement levels by Medicare/Medicaid and third party
insurers, combined with similar dynamics in Europe and Asia are expected to
result in significant growth in FDG studies, which should translate into
increased oxygen-18 demand. Buyers of oxygen-18 range from the single site users
who purchase in gram quantities, to the radiopharmacy companies who will buy in
kilogram quantities.

    To meet this demand, we announced in May 1999 a multi-year joint cooperation
agreement with Global Scientific Technologies in Russia, which is the third
largest producer of oxygen-18 in the world. With market demand exceeding supply
and increasing market prices, this agreement encompasses current production,
increased production through recycling, new production facilities in the United
States and elsewhere, and new value-added forms of the isotope. The agreement
has resulted in a shift in our sales and marketing strategy from smaller buyers
to larger commercial providers of irradiation equipment, flourine-18, and FDG,
who will likely dominate the market and whom we anticipate will favor long-term
supply partnerships.

    We will initially focus our sales efforts on the smaller buyer until assured
supplies permit us to aggressively pursue long-term supply agreements with the
large radiopharmacy companies, like PetNet, Syncor, and Nycomed-Amersham, who we
believe will dominate this market through their networks of regional
radiopharmacies. To supply this anticipated demand, we are exploring a
combination of options that include exclusive distribution rights for existing
production, investment in expansion of existing production facilities, and
investment in our own production facilities.

    Most phases of the development and ongoing production of these materials are
controlled by the FDA and similar foreign regulatory agencies. This fact,
combined with the complexities of production and distribution, has resulted in a
market with only a few manufacturers. Tight quality control requirements, and
the importance to the health-care industry of a ready supply of these drugs,
leads

                                       34

these manufacturers to pay close attention to their stable isotope suppliers.
Quality, supply reliability, ultimate source, breadth of offerings, price and
track record are principal factors that a manufacturer considers in evaluating a
potential stable isotope supplier. Much of the material used to manufacture such
products originates in countries of the former Soviet Union. While the U.S.
Department of Energy ("DOE") has facilities that can manufacture stable
isotopes, its costs are usually substantially higher because of the full cost
recovery mandated by legislation governing the DOE's operations.

    We believe that we are capable of supplying many of the stable isotopes
currently sold in this market. Since the original impetus for new applications
of stable isotopes in health care frequently comes from the drug manufacturers,
we have recently begun marketing our products, services and capabilities to the
existing and emerging manufacturers.

    ISOTOPICALLY PURE SEMICONDUCTORS.  Isotopic purification of carbon used to
manufacture synthetic diamonds has resulted in substantially improved physical
properties. Published tests conducted by General Electric Corporation and others
have shown that the removal of a small amount of carbon-13 to produce
isotopically pure carbon-12 synthetic diamonds can result in a 50% improvement
in thermal conductivity of the diamond at room temperature. Additionally the new
diamond was found to be highly transparent, and the transmission of certain
frequencies of laser light was increased by approximately ten times without the
diamond sustaining damage. General Electric Corporation has stated that
isotopically pure carbon-12 diamonds may enable faster, more reliable computers
due to their superior heat removal capability and may result in more efficient
cutting tools and more accurate laser measurement devices, and that the new
diamonds may enable designers to use lasers in semiconductor fabrication
techniques.

    Studies conducted at Lawrence Berkeley Laboratory and the Max Planck
Institute on isotopically pure germanium have shown thermal conductivity
improvements similar to those found in isotopically pure carbon-12 diamonds. The
thermal conductivity of a thin film of isotopically pure silicon-28 was
demonstrated by a researcher at Brown University in 1997. The thermal
conductivity was found to be 60% higher than natural silicon at room temperature
and 40% higher at 100 degrees Centigrade. We believe that this level of thermal
conductivity improvement should significantly benefit the semiconductor
industry, and therefore we have decided to concentrate our development efforts
on silicon-28 for the near term future.

    According to the Semiconductor Industry Association, the 1998 market for
silicon wafers and other semiconductor substrates was approximately $7 billion.
Improvement in the thermal conductivity of silicon is important since as the
feature size of semiconductor devices continuously decreases, the power density
increases. As power density increases, more heat is generated per unit volume
causing the device-operating temperature to rise. The semiconductor industry is
moving toward lower operating voltages and is using mechanical means to remove
bulk heat, but we believe that greater heat dissipation on the micro scale will
become even more important to the industry in the future. Better thermal
conductivity directly affects heat removal capability, and indirectly improves
device speed. As the industry moves toward deep sub-micron devices, the ability
to remove heat will be a prime consideration for the semiconductor industry.

    We believe that if commercial opportunities emerge, isotopically pure
silicon-28, deployed as wafers or substrates and as silane or trichlorosilane
gas for building epitaxial layers should find a niche in the manufacture of
high-performance silicon semiconductors. Even at a premium price, we believe
that silicon-28 can compete in high-performance, less cost-driven markets. We
have produced isotopically pure silicon-28 silane gas, and we have produced
silicon-28 epitaxial layers on natural silicon substrates.

    We believe that these materials meet industry standards for semiconductor
fabrication and have met the quality standards for microprocessor fabrication.
We have provided specimens to academic institutions and industrial semiconductor
manufacturers. These institutions have agreed to measure

                                       35

certain physical and electrical properties of silicon-28, manufacture devices,
and compare the performance to devices made with natural silicon. Epitaxial
wafers with layers of silicon-28 made to custom specifications are currently for
sale in pilot-scale quantities. It is our goal to provide silicon-28 epitaxial
wafers to a wide variety of semiconductor manufacturers, but the best near term
opportunity appears to be microprocessors and certain power semiconductors. To
this end, we delivered wafers to Advanced Micro Devices in the fourth quarter of
fiscal 1999.

    During fiscal 1999, we acquired an exclusive license to two U.S. patents
owned by Yale University, concerning isotopically pure semiconductor devices.
These patents expire in 2009 and 2012 and cover silicon, germanium, gallium
arsenide and most isotopically pure compound semiconductors. We believe that if
evaluations demonstrate the commercial feasibility of one or more products,
demand could emerge in certain segments of the semiconductor market. There can
be no assurance, however, that these evaluations will demonstrate the commercial
feasibility of any products, that we will be able to commercialize any such
products or that a market will emerge for any such products.

    During fiscal 1999, we signed a joint research and development agreement
with Silex Systems Ltd. The agreement calls for Silex to partially fund some of
our development activities and for Silex to assess the feasibility of building a
silicon isotope separation plant using Silex's patented laser isotope separation
process. These agreements represent the launch of our efforts to ensure a large
supply of silicon isotopes at a reasonable cost to support the large-scale
manufacture of isotopically pure silicon wafers. In December 1999, we entered
into a Supply Agreement with Eagle-Picher Technologies, LLC for the supply of
isotopically pure silicon-28 from its Oklahoma-based facility. This Supply
Agreement superceded a prior agreement, signed in fiscal 1999, with Eagle-Picher
to cooperate on developing silicon-28 production capabilities at the Oklahoma
facility. As of April 30, 2000, no silicon-28 has been delivered by
Eagle-Picher. Eagle-Picher expects to commence deliveries in the second half of
calendar year 2000.

RESEARCH AND DEVELOPMENT

    Consistent with our product development strategy, we are seeking to identify
and evaluate a variety of new stable isotope products and potential markets for
economic and technical feasibility. We will continue to fund research and
development to improve technologies for isotope separation and materials
processing technologies. During fiscal 1999 and 1998, research and development
expenses were $1,155,000 and $811,000, respectively. Research and development
expenditures during the nine months ending January 31, 2000 were approximately
$919,000.

    We have focused our efforts on developing lower-cost carbon-13 separation
methods and the production of high chemical-purity silicon-28 silane gas and
epitaxial wafers made from that silane gas. To date this work has been performed
for us on a sub-contract basis by unaffiliated contractors. We attempt to
retain, to the maximum extent possible, ownership of any intellectual property
resulting from such work.

    We have been seeking to enter into formal joint development agreements with
a number of semiconductor industry participants in the areas of silicon wafer
manufacture and various potential applications for isotopically engineered
silicon. During fiscal 1999, we signed an agreement with Voltaix, Inc. to be the
distributor of our products for the ion implantation industry. The first product
being sold in accordance with the Voltaix agreement is silicon tetrafluoride
enriched in the silicon-29 isotope. The isotopically enriched materials allow
higher beam currents and higher productivity than the natural silicon
tetrafluoride currently used in the industry.

PATENTS AND PROPRIETARY RIGHTS

    We rely primarily on a combination of trade secrets, confidentiality
procedures and contractual provisions to protect our technology. Despite our
efforts to protect our rights, unauthorized parties may

                                       36

attempt to copy aspects of our products or to obtain and use information that we
regard as proprietary. Policing unauthorized use of our technology and products
is difficult. In addition, the laws of many countries do not protect our rights
in information, materials and intellectual property that we regard as
proprietary to as great an extent as do the laws of the United States. There can
be no assurance that our means of protecting our rights in proprietary
information, materials and technology will be adequate or that our competitors
will not independently develop similar information, technology, or intellectual
property.

    We currently have no patents in our own name and have not filed any patent
applications. We have rights to several isotopically engineered innovations
regarding electronic and optical materials, which we believe may be patentable.
Ongoing work in the area of isotope separation by chemical means may also lead
to patentable inventions.

    In April 1999, we announced that we had entered into an exclusive licensing
agreement with Yale University that entitles us to exclusive intellectual
property right to patents covering semiconductor devices derived for
isotopically engineered materials. The license requires payment by us of a
royalty based on a percentage of our, or our sublicensees', net sales of
products derived from technology covered by the Yale patents (#5,144,409, dated
September 1, 1992, and #5,442,191, dated August 15, 1995).

SIGNIFICANT CUSTOMERS

    Four separate customers accounted for 10% or more of net revenues in fiscal
1998: 47%, 18%, 12% and 11%. Two separate customers accounted for 10% or more of
net revenues in fiscal 1999: 23% and 13%. At January 31, 2000, one customer
accounted for approximately 18% of net revenues during the nine months ended
January 31, 2000. The same customer accounted for approximately 17% of net
revenues during the nine months ended January 31, 1999.

COMPETITION

    The markets for our products and proposed products are highly competitive,
and we expect that competition will continue and increase as markets grow and
new opportunities are realized. Some of our current competitors, and many of our
potential competitors, are larger and have significantly greater financial,
technical, marketing and other resources. Some of our competitors may form
partnerships or alliances with large pharmaceutical or electronics companies,
with the resulting entity possessing more market strength than we have. Our
competition varies greatly depending on which product or industry is considered.

    DEPLETED ZINC.  During fiscal 1999, we were among the leading producers of
depleted zinc. We also believed that other entities or persons were expected to
begin producing depleted zinc in substantial quantities in the near future.
Several such possible producers have adequate technical and financial resources
to become viable competitors in the near future. In particular, Siemens has
indicated that it has a relationship with Ultracentrifuge Netherlands ("UCN")
and GE has indicated that it may establish a second Russian supply source. UCN
also competes with us in the markets for medical target isotopes. This
competitive environment, along with many other factors, contributed to our
decision to sell our depleted zinc business to Eagle-Picher Technologies, LLC in
December 1999.

    SILCS AND DBT MATERIALS  We have several larger and numerous smaller
competitors in the markets for the SILC products, and we will have additional
competitors if we offer breath test diagnostic products and additional SILCs in
the future. Two of these companies, Cambridge Isotope Laboratories Inc., and
Isotec, Inc., have their own isotope separation capability, while all of our
competitors produce some combination of SILCs and DBT substrates. Two recently
merged companies in the U.S. have received FDA approval for a carbon-13 UBT.
Several companies in Europe have also received regulatory approval. Our
principal current competitors and potential competitors also include

                                       37

MassTrace, euriso-top, Aldrich Chemicals, Icon Services, Omicron, C/D/N Isotopes
and Martek Biosciences. We have in the past, and may in the future, sell
products to or purchase products from these companies.

    SEMICONDUCTOR MATERIALS.  Due to the early stage of the semiconductor
materials opportunities, we have not identified material competitors in these
markets. However, given the potential size and importance of these new potential
markets, we anticipate that substantial competition will emerge if these markets
develop.

    Many of the areas in which we are or intend to compete are rapidly evolving.
There can be no assurance that an existing or potential competitor has already
developed, or may develop, a patentable product or process, which will
substantially prevent us from competing in our intended markets.

    We compete primarily on the basis of product performance, proprietary
position and price. Some of our products may also compete based on product
efficacy, safety, patient convenience and reliability. In many cases the first
company to introduce a product to the market will obtain at least a temporary
competitive advantage over subsequent market entrants.

MANUFACTURING AND SUPPLY

    Consistent with our strategy to minimize capital expenditures, we obtain
isotopes through multi-year supply agreements. To a lesser extent, from time to
time, we also obtain stable isotopes from a variety of other Russian isotope
sources and may invest in our own isotope production facilities in the future
upon determining the optimum production technology. Currently, we obtain
substantially all of our isotopes from Russia, the Republic of Georgia, and
other locations within the former Soviet Union. In December 1999, we entered
into a Supply Agreement with Eagle-Picher Technologies, LLC, for the right to
purchase enriched silicon and carbon isotopes from its facilities in Oklahoma.
In addition, Eagle-Picher has an obligation to provide us 200 kilograms of
isotopically pure silicon-28 during calendar year 2000. The first deliveries
from the Eagle-Picher silicon facility are scheduled to begin in April 2000.

    We entered into a Supply Agreement dated July 1996 with Techsnabexport and
an isotope enrichment plant located in Russia, which is owned by the Ministry of
Atomic Energy of the Russian Federation, which is part of the cabinet of the
government of the Russian Federation. Under the Supply Agreement, the plant
produced depleted zinc and other stable isotopes for us. We assigned this supply
agreement to Eagle-Picher in December 1999.

    We are still receiving other stable isotopes from plants located in Russia.
The enforceability of the agreement might be subject to the greater degree of
uncertainty than if the agreement was with a U.S. company and if disputes were
resolved in the U.S. The supply of stable isotopes could be directly affected by
political, economic and military conditions in Russia. Accordingly, our
operations could be materially adversely affected if hostilities involving
Russia should occur, if trade between Russia and the United States were
interrupted or curtailed, or if we should fail to obtain and maintain all
necessary governmental approvals. We have assigned this supply agreement to
Eagle-Picher and we no longer have any rights under it.

    Operations in Russia entail certain other risks, including, among others,
supply disruptions as well as introduction of tariffs and fluctuations in
freight rates. See "RISK FACTORS," above. There can be no assurance that our
relationship with our processor in Russia will be successfully maintained.
Disruption or termination of our supply sources could delay shipments by us and
could have a material adverse effect on our business, financial condition and
results of operations. We do not presently maintain political risk insurance but
we will evaluate the desirability and availability of such insurance in the
future.

                                       38

    The plant with which we have the agreement described above is one of four
similar plants which were designed to address the former Soviet Union's and
certain other countries' needs for low enriched uranium for commercial nuclear
power plant fuel and for highly enriched uranium for military purposes.
Following the nuclear accident at Chernobyl, certain of the Russian nuclear
power plants have been shut down, reducing demand on these enrichment plants. In
addition, in recent years the demand on these plants to produce products for
military purposes has declined. In part in response to these trends, the plant
has converted a portion of its capacity to processing stable isotopes, and we
believe that additional capacity could be converted if the plant decided to do
so. We believe that the plant has the potential capacity to meet all of our
foreseeable needs for the processing of stable isotopes. We believe that one or
more of the other similar enrichment plants may convert part of its capacity to
the production of stable isotopes should market demand grow substantially.
Certain other facilities elsewhere in the world, including the Oak Ridge
National Laboratory in Oak Ridge, Tennessee (which relies on government funding
for continuing production), and certain private and pseudo-governmental
organizations in Great Britain, Germany, The Netherlands and South Africa, have
the potential to produce stable isotopes and, in certain cases, actually produce
isotopes.

    Recognizing the need to have more control over the production of Isonics'
isotopes, we announced plans for a joint venture with the Institute of Stable
Isotopes in the Republic of Georgia, the pre-eminent center for the separation
of light isotopes in the countries that comprised the former Soviet Union. This
agreement calls for investment by both parties to increase carbon-13 production
at the Institute and provides for exclusive sales of all carbon-13 production to
Isonics. This agreement also grants rights to us to employ the Institute's
separation technology at new production facilities anywhere in the world. The
two parties have also agreed to cooperate on development projects, which would
include new isotope production technologies, as well as, new applications of
isotope products.

    To increase capacity and to geographically diversify our production of
certain isotopes, on December 1, 1999, we entered into a Supply Agreement with
Eagle-Picher Technologies, LLC, for it to supply us with enriched isotopes of
silicon and carbon. We have already purchased 200 kilograms from Eagle-Picher to
be delivered during 2000. Eagle-Picher expects to produce these isotopes from
its facilities in Oklahoma, a portion of which are currently under construction.
There can be no guarantee, however, that the facility will be able to produce
high-purity isotopes on commercially reasonable terms. We believe that this
relationship with Eagle-Picher may improve our profitability and will improve
the security of our supply if the facility performs as expected.

    We have historically depended upon a single processor, located in Russia,
for one process involved in the manufacturing of our products, and upon a single
supplier or a limited number of suppliers and processors for certain other
manufacturing processes. Although we do have written agreements with certain of
our suppliers and processors, we do not have any written agreements with other
suppliers and processors. We seek to reduce our dependence on our sole and
limited suppliers, but disruption or termination of any of the sources could
occur, and such disruptions could have at least a temporary material adverse
affect on our business, financial condition and results of operations. Moreover,
a prolonged inability to obtain alternative sources for processing could
materially adversely affect our relations with our customers. Although the
relationship with Eagle-Picher should provide greater security for our supply of
silicon and carbon isotopes, if the facility performs as expected, there can be
no assurance that it will in fact do so.

GOVERNMENT REGULATION

    Regulation by government authorities in the United States and other
countries is a significant consideration in the development, production,
distribution and marketing of our products and in our continuing research,
development, and other activities. In order to clinically test, manufacture,
distribute, market, and sell products, especially those intended for therapeutic
or diagnostic use, mandatory procedures and safety and other standards
established by applicable regulatory authorities

                                       39

must be followed. In many cases, specific approval to clinically test and
commercially distribute such products must be obtained from numerous
governmental authorities. Furthermore, we are subject to various laws,
regulations and requirements relating to such matters as the import and export
of our products, ensuring safe working conditions, laboratory and manufacturing
practices, the use and disposal of hazardous or potentially hazardous substances
used in connection with our research, development and manufacturing activities.
Some of the regulations are summarized below.

    FDA REGULATION.  We are not currently subject to any FDA regulation because
we do not currently manufacture any DBTs, drug products, or other medical
devices. Our customers may, in many cases, be subject to FDA regulation. If we,
in the future, test, manufacture, market, distribute, export, or sell diagnostic
products (such as any DBTs) or medical devices, we will also likely be subject
to extensive and rigorous regulation by the United States and other countries in
which we may choose to test, manufacture or market our proposed diagnostic
products. We have not determined those countries, other than the United States,
where we might seek regulatory approvals to market any such products it may
develop. The products we intend to develop are subject to rigorous preclinical
and clinical testing and other FDA approval requirements, and similar
requirements in most other countries.

    EXPORT AND ENVIRONMENTAL CONTROLS.  Certain of our products and technology,
particularly those having potential nuclear energy or military applications,
such as depleted zinc and related technology, are subject to stringent controls
over their manufacture, use, distribution, dissemination and export. In many
cases, such activities may require approvals or licenses from various U.S. and
foreign governmental agencies, and compliance with substantial regulatory
controls. Such approvals can be difficult to obtain and maintain and may not be
obtainable from certain countries. Furthermore, such approvals or licenses may
be restricted or terminated because of changes in laws, regulations, policies
governing those approvals and licenses, or changes in the political or other
matters in the countries granting such approvals or licenses to which our
products and technology would be exported.

    Likewise, certain of our current and potential operations may necessitate
submitting registrations or notifications to federal and state regulatory
authorities responsible for environmental and related matters, including the
U.S. Environmental Protection Agency ("EPA"). Additionally, we are required to
comply with stringent controls pertaining to the handling and distribution of
our products and operations, including under certain conditions obtaining
governmental approvals and licenses, either of which may be subject to
significant restrictions. Violation of any of these regulatory controls may
subject us to significant administrative civil and criminal penalties, including
loss of our approvals and licenses, or the imposition of additional restrictions
on our operations. There can be no assurances that we will be able to obtain and
maintain the approvals or licenses necessary to successfully market our products
and technology, or that it will be able to comply with applicable laws and
regulations. Any such failure to obtain such licenses or approvals, where
required, and comply with such laws and regulations may materially and adversely
affect our business, financial condition and results of operations.

    REGULATION OF NON-MEDICAL CHEMICAL PRODUCTS.  The import, export, handling,
transportation, sale, storage and other activities undertaken in connection with
our non-medical products are subject, or potentially subject, to substantial
federal, state, local and foreign government controls pertaining to hazardous
chemicals and chemical wastes, import export controls and other matters. These
regulations are complex, pervasive and constantly evolving. Our ability to
effect and maintain compliance with these controls is important to our
commercial success.

    With respect to transportation of our products, we rely predominantly on
Russian and U.S. freight carriers to handle and deliver all our shipments, and
utilize domestic overnight courier services for shipments to our customers.
These carriers must comply with Department of Transportation ("DOT") regulations
in the shipping and packaging of the stable isotope chemicals. We must also
comply with DOT regulations when packaging material kept in inventory for
domestic shipment. As required under

                                       40

federal and state law, we have prepared Material Safety Data Sheets ("MSDS"),
which are enclosed with each product shipment. We must periodically update our
MSDS sheets based on new literature reports. We cannot assure that our MSDS
sheets will continue to be in compliance with applicable requirements.

    The shipments received at our Columbia, Maryland facility are subject to
Federal and Maryland regulations pertaining to hazardous chemicals and hazardous
waste disposal. These shipments are stored in an area of the facility designated
for such materials. Currently, we are considered a small quantity generator of
hazardous waste and will rely on certified haulers to dispose of our minimal
amounts of hazardous waste. We believe we are in compliance, in all material
respects, with applicable federal and state environmental regulatory
requirements.

    Should the levels of hazardous waste increase as our inventory and handling
operations increase in volume, we would then have to comply with Environmental
Protection Agency ("EPA") requirements and obtain an EPA ID number, which is
costly and requires an increased investment of personnel and money. We have no
experience in this area of compliance and we would have to rely on outside
consultants or hire additional employees with pertinent experience and training.
Potentially, if substantially larger inventories of hazardous chemicals must be
maintained at the Maryland facility, we might have to move to new facilities in
order to meet EPA requirements for the storage of hazardous chemicals.

    The shipments from Russian manufacturing sources now enter the U.S. duty
free (without tariff); however, there can be no assurance that such duty-free
importation will continue. If the shipments become subject to tariff, we cannot
assure that we will be able to sell the imported products or that the products
will be commercially viable because of these increased tariff costs.

    The Nuclear Regulatory Commission ("NRC") has authority to regulate the
importation and exportation of deuterium containing chemicals whose ratio of
deuterium atoms to hydrogen atoms exceed 1:5,000. At present, the deuterium
containing compounds that we import do not require any special licenses or
importation authorization. There can be no assurances that the NRC will continue
these policies. The NRC regulates exports of deuterium containing chemicals
under general license. We will not be able to ship these chemicals to certain
countries that require a special license for such shipments; none of these
countries represent significant current or expected future markets for our
anticipated and present products. In addition, certain technology or products
that we have or may in the future develop, may be subject to other government
controls pertaining to armaments, including the need to obtain special licenses
for exports. The imposition of such controls may impair our ability to broadly
market such products.

PRODUCT LIABILITY AND INSURANCE

    Our business exposes us to potentially substantial product, environmental,
occupational and other liability risks which are inherent in product research
and development, manufacturing, marketing distribution and use of our products
and operations, including, but not limited to, products used in nuclear power
plants and medical device products. We have product liability insurance in order
to protect ourselves from such potential exposures. There can be no assurance
that adequate insurance coverage will be available at an acceptable cost, if at
all, or a product liability or other claim would not materially and adversely
affect our business or financial condition.

    The terms of our agreements with our customers provide that liability to
nuclear power plant utilities is limited to our standard warranty to replace
non-conforming product, and liability for consequential damages caused by the
improper use of our products is limited by contractual terms. Nevertheless, one
or more third parties could bring an action against us based on product
liability, breach of warranty or other claims, and, there can be no assurance
that the foregoing contract clauses

                                       41

would effectively limit our liability in any such actions. We are no longer
supply depleted zinc to nuclear power plants.

EMPLOYEES

    As of April 30, 2000, we had 31 full and part-time employees, of whom eight
have Ph.D.s and one other has an advanced degree in engineering. Approximately
seven employees are involved in research and product development, ten in
manufacturing and sourcing, and fourteen in business development and
administration, but such employees' responsibilities may also encompass areas
other than their primary area of responsibility. We consider our relations with
our employees to be good. None of our employees are covered by a collective
bargaining agreement.

PROPERTIES

    We relocated our headquarters to Golden, Colorado in December 1998, and now
share facilities with our wholly-owned subsidiary, Interpro. Interpro leases
approximately 41,000 square feet of office, research and production facilities.
The lease expires in July 2001. The facility is used for contract research and
development and materials processing as well as administration. By combining our
headquarters into the facility of our subsidiary, we have significantly reduced
our costs for both space and administrative support. We also lease 650 square
feet for an administrative office in Columbia, Maryland that expires
November 30, 2001. Chemotrade leases office space in Dusseldorf and Leipzig,
Germany.

LEGAL PROCEEDINGS

    We are not subject to any pending or, to our knowledge, threatened, legal
proceedings.

CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL
  DISCLOSURE

    None.

                                       42

                                   MANAGEMENT

DIRECTORS AND EXECUTIVE OFFICERS.

    The following table sets forth the names and ages of all the Directors and
Executive Officers of Isonics, and the positions held by each such person. The
directors each serve until their successors are duly elected and qualified;
officers are appointed by, and serve at the pleasure of, the Board of Directors.



NAME                                          AGE                           POSITION
- ----                                        --------   ---------------------------------------------------
                                                 
James E. Alexander........................     51      President, Chief Executive Officer and Chairman of
                                                       the Board
Boris Rubizhevsky.........................     49      Senior Vice President, Vice Chairman and Director
Daniel J. Grady...........................     45      Vice President, Medical, Research and Diagnostics
Stephen J. Burden.........................     51      Vice President, Semiconductor Materials
Brantley J. Halstead......................     42      Chief Financial Officer, Vice President, Finance
Robert Cuttriss...........................     51      President of Interpro
Herbert Hegener...........................     53      Managing Director of Chemotrade
Lindsay A. Gardner(1)(2)..................     49      Director
Richard Parker(1)(2)......................     56      Director
Larry J. Wells(1)(2)......................     57      Director


- ------------------------

(1) Member of the Compensation Committee.

(2) Member of the Audit Committee.

    Each of the directors holds office until the next annual meeting of
shareholders and until his or her successor is elected and qualified or until
his or her earlier death, resignation, or removal. Each officer serves at the
discretion of the Board.

    Mr. Alexander is our co-founder and has served as our President, Chief
Executive Officer and a director since our inception. He has worked full-time
for Isonics since January 1994. From June 1972 to December 1993, he worked in a
variety of technology positions at General Electric Corporation ("GE") in the
aircraft engine and nuclear power businesses, where his last position was
Manager of Technology Programs. Mr. Alexander received his Bachelors degree in
Metallurgical Engineering from the University of Cincinnati and performed
graduate work in materials science there. He earned a Masters degree in Business
Administration from Santa Clara University.

    Mr. Rubizhevsky is also a co-founder of Isonics and has been a Senior Vice
President and a director since inception and became Vice Chairman in
March 1997. From November 1986 through December 1994, he owned and operated SAR
Marketing, a consulting firm providing business advice and services to large
multinational corporations. From June 1977 to May 1986, Mr. Rubizhevsky worked
at General Electric Corporation as Business Development Manager in various
international locations. He received his Bachelors degree in Engineering from
Stevens Institute of Technology.

    Dr. Grady joined us as Vice President, Medical, Research and Diagnostics in
1995. From March 1994 through September 1995, Dr. Grady was Vice President of
Research and Development at Sopha Medical Systems, a medical diagnostic imaging
equipment manufacturer. From April 1991 until March 1994, he served as Marketing
Manager, Nuclear Energy for General Electric Corporation ("GE"). From May 1988
through March 1991, Dr. Grady served as Software Engineer Manager, Nuclear
Medicine for GE in England. From October 1984 through May 1988, he served as
Clinical Applications Manager for GE Nuclear Medicine. Between June 1981 and
October 1984, he served as

                                       43

Engineering Analysis Section Head for TRW. Dr. Grady received his Bachelors and
Masters degrees, and Ph.D. in Nuclear Engineering from the University of
Michigan.

    Dr. Burden joined us in 1997. Prior to joining Isonics Dr. Burden was
Director of Product Development at sp3, Inc., a manufacturer of diamond-coated
tools. From 1984 to 1993, he was Manager of Advanced Materials R&D at GTE
Valenite, a subsidiary of GTE Corporation, a manufacturer of cutting tools. From
1974 to 1984, Dr. Burden was employed by General Electric Corporation in various
capacities. Dr. Burden has a Ph.D. and a Masters of Science degree, both in
Materials Science, and both from Drexel University. Dr. Burden has a Bachelors
degree in Science Engineering, and an MBA from the University of Michigan.

    Mr. Halstead joined us as Chief Financial Officer in 1999 and was promoted
to Vice President, Finance effective January 30, 2000. Most recently,
Mr. Halstead was Chief Financial Officer of Bio-Medical Automation, Inc.
(formerly OZO Diversified Automation, Inc.), from 1997 through 1999.
Mr. Halstead also has nine years of management consulting experience, including
five years with Deloitte & Touche LLP. Prior to earning his Masters of Business
Administration in Finance from the University of Denver, Mr. Halstead worked as
a metallurgical engineer. Mr. Halstead received his Bachelors degree in
Metallurgical Engineering from the Colorado School of Mines, and his Masters of
Accountancy from the University of Denver.

    Dr. Cuttriss has served as the President of Interpro since 1993. With
29 years experience in process operations in the mining and metallurgical
industries, Dr. Cuttriss' experience includes holding the title of principal
consultant and director of Metallurgy International, Inc., from 1983 through
1993. He has undertaken management and technical assignments covering the
design, commissioning and operation of mineral treatment plants, technical
audits and evaluations, pilot plant testing and process development for projects
throughout the world. Dr. Cuttriss received his Bachelors and Ph.D. degrees in
Metallurgy from the University of Melbourne and his Masters in Metallurgy from
the University of Queensland.

    Mr. Hegener is a co-founder of Chemotrade and has served as the President
since its formation in 1991. From 1988 to 1991, Mr. Hegener was with Medgenix
Deutschland GmbH-Dusseldorf, and his last position with this firm was Managing
Director. From 1973 to 1988, Mr. Hegener worked at the Hempel Group, Dusseldorf,
Germany, in various management positions. Mr. Hegener is a specialist in stable
and radioactive isotopes. He has degrees in Chemistry and Economics.

    Ms. Gardner was elected a director in September 1993. She has served from
1991 through the present as President of LG Associates, a US-based management
consulting firm providing materials management expertise to foreign company
affiliates of US companies in developing countries. During her tenure at LG
Associates Ms. Gardner resided in Moscow, Russia from September 1991 to
January 1994, when she moved to Beijing, China. From 1977 to 1991, Ms. Gardner
worked for General Electric Corporation in a variety of management and
functional positions including international marketing, quality assurance and
materials. Ms. Gardner received a Bachelors degree in International Economics
from The George Washington University Elliott School of International Affairs,
and earned a Masters of Business Administration from the University of
Louisville.

    Mr. Parker has served as a director since August 1998. Mr. Parker is
presently Vice-President of Distribution Sales for Cypress Semiconductor and has
held that position since December 1997. Previously, Mr. Parker was Director of
Sales for Cypress from April 1984 to December 1997. Prior to joining Cypress, he
held various sales and marketing management positions at Fairchild Semiconductor
from 1973 to 1984. He received a Bachelors degree in Education from the
University of North Dakota.

    Mr. Wells was elected a director of Isonics in January 2000. Since 1989,
Mr. Wells has been a general partner of SVP Management Company, the management
company for Sundance Venture Partners, L.P., a venture capital fund. From 1983
to 1989, Mr. Wells served as Vice President of

                                       44

Citicorp Venture Capital then became Senior Vice president of Inco Venture
Capital. Mr. Wells is a director of Cellegy Pharmaceuticals, Identix, Inc., as
well as several privately held companies. Mr. Wells received his bachelors
degree in Economics and earned a masters degree in Business Administration from
Stanford University. Mr. Wells was previously a director of Isonics from
September 1996 through December 1998.

    There are no significant employees who are not also directors or executive
officers as described above. As of April 30, 1999, and subsequently, there were
and are no family relationships among the officers, directors or any person
chosen by Isonics to become a director or officer. No arrangement exists between
any of the above officers and directors pursuant to which any one of those
persons was elected to such office or position.

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

    The following table sets forth certain information regarding the ownership
of Isonics Common Stock as of June 12, 2000, by: (i) each of the executive
officers named in the Summary Compensation Table; (ii) all executive officers
and directors of Isonics as a group; and (iii) all those known by Isonics to be
beneficial owners of more than five percent of its Common Stock.

    This table is based upon information supplied by officers, directors and
principal shareholders and Schedules 13D and 13G filed with the Securities and
Exchange Commission ("SEC"). Unless otherwise indicated in the footnotes to this
table and subject to community property laws where applicable, we believe that
each of the shareholders named in this table has sole voting and investment
power with respect to the shares indicated as beneficially owned. Applicable
percentages are based on 10,792,160 shares of Common Stock outstanding on
June 12, 2000, adjusted as required by rules promulgated by the SEC. Subsequent
to the date of this prospectus, shareholders converted 180,000 shares of
Series A Convertible Preferred Stock into 180,000 shares of our Common Stock.
This conversion increases the basis for the following calculations 180,000
shares to 10,972,160. This will reduce the percentages listed below by
approximately 1.67% each.



                                                                     BENEFICIAL OWNERSHIP
                                                              -----------------------------------
BENEFICIAL OWNER                                              NUMBER OF SHARES   PERCENT OF TOTAL
- ----------------                                              ----------------   ----------------
                                                                           
James E. Alexander(1).......................................     2,104,779             19.5%
Boris Rubizhevsky(2)........................................     1,922,293             17.7%
Stephen J. Burden(3)........................................       289,212              2.6%
Daniel J. Grady(4)..........................................       241,769              2.2%
Brantley J. Halstead(5).....................................       141,000              1.3%
Robert H. Cuttriss(6).......................................       307,982              2.8%
Herbert Hegener(7)..........................................       213,865              2.0%
Lindsay Gardner(8)..........................................       289,761              2.7%
Richard Parker(9)...........................................        40,000              0.4%
Larry Wells(10).............................................       174,011              1.6%
All executive officers and directors as a group
  (10 persons). The address for all of the above directors
  and executives officers is:
  5906 McIntyre Street, Golden, CO 80403....................     5,724,672             49.1%
Richard Grossman(11)........................................     1,873,336             17.3%
Anfel Trading(12)...........................................       666,668              5.8%
Eagle-Picher Technologies, LLC(13)..........................     3,130,435             29.0%


- ------------------------

 (1) Includes (i) 25,000 shares of Common Stock underlying options which are
     currently exercisable, and (ii) 45,455 shares of Common Stock held in the
     name of The James & Carol Alexander Family Foundation.

                                       45

 (2) Includes (i) 320,468 shares of Common Stock held jointly with
     Mr. Rubizhevsky's wife, (ii) 22,500 shares of Common Stock underlying
     options which are currently exercisable, and (iii) 66,666 shares of Common
     Stock underlying 33,333 shares of Series A Convertible Preferred Stock and
     33,333 warrants to purchase Common Stock of Isonics. Subsequent to the date
     of this prospectus, Mr. Rubizhevsky converted 33,333 shares of Series A
     Convertible Preferred Stock shares into 33,333 shares of our Common Stock.

 (3) Includes (i) 192,887 shares of Common Stock underlying options of which
     80,004 are not exercisable as of June 12, 2000, and (ii) 33,333 shares of
     Common Stock underlying 33,333 shares of Convertible Preferred Stock.
     Subsequent to the date of this prospectus, Dr. Burden converted 33,333
     shares of Series A Convertible Preferred Stock shares into 33,333 shares of
     our Common Stock.

 (4) Includes 222,965 shares of Common Stock subject to stock options that are
     currently exercisable.

 (5) Includes 141,000 shares of Common Stock underlying options (of which 86,000
     have vested as of June 12, 2000 and which are currently exercisable.)

 (6) Includes (i) 287,982 shares of Common Stock held in the name of Metallurgy
     International, Inc. In which Dr. Cuttriss and his wife, P. D. Cuttriss, are
     controlling shareholders, and (ii) 20,000 shares of Common Stock underlying
     options that are currently exercisable.

 (7) Includes 35,000 shares of Common Stock underlying warrants which are
     currently exercisable.

 (8) Includes 40,000 shares of Common Stock underlying stock options that are
     currently exercisable.

 (9) Includes 40,000 shares of Common Stock underlying stock options which are
     currently exercisable.

 (10) Includes 30,000 shares of Common Stock underlying stock options which are
      currently exercisable. Also includes 144,011 shares owned by Daystar
      Partners, L.P. of which an affiliate owned by Mr. Wells is general
      partner, and in which Mr. Wells owns a 9.9% equity interest.

 (11) Includes beneficial ownership of the following shares: (i) 40,000 shares
      of Common Stock underlying 20,000 shares of Convertible Preferred Stock
      and 20,000 warrants owned of record and beneficially by Richard Grossman,
      (ii) 40,000 shares of Common Stock underlying 20,000 shares of Convertible
      Preferred Stock and 20,000 warrants owned of record and beneficially by
      Orin Hirschman (of which shares Mr. Grossman disclaims beneficial
      ownership), (iii) 1,106,668 shares of Common Stock underlying 553,334
      shares of Convertible Preferred Stock and 553,334 warrants owned of record
      and beneficially by Adam Smith Investment Partners, L.P., (iv) 226,668
      shares of Common Stock underlying 113,334 shares of Convertible Preferred
      Stock and 113,334 warrants owned of record and beneficially by Adam Smith
      Investments, Ltd., and (v) 500,000 shares of Common Stock underlying
      500,000 warrants owned of record and beneficially by Adam Smith &
      Company, Inc., all as set forth on the Schedule 13D filed by such persons
      on August 12, 1999. The business addresses of Richard Grossman and Orin
      Hirschman, and the principal executive offices of Adam Smith Investment
      Partners, L.P. and Adam Smith & Company, Inc., are located at 101 East
      52(nd) Street, New York, New York 10022. The principal executive offices
      of Adam Smith Investments, Ltd. are c/o Insinger Fund Administration (BVI)
      Limited, Tropic Isle Building, P.O. Box 438, Road Town, Tortola, British
      Virgin Islands.

 (12) Includes 666,668 shares of Common Stock underlying 333,334 shares of
      Convertible Preferred Stock and 333,334 warrants. The principal executive
      offices of Anfel Trading Ltd. are c/o Me. Andre Zolty, 24 Route De
      Malagnou, 1208 Geneva, Switzerland.

 (13) This share ownership results from Eagle-Picher's exercise of a warrant to
      purchase 4,000,000 shares of our Common Stock at $3.75 per share which
      resulted in Eagle-Picher acquiring 3,130,435 shares upon surrender of the
      warrant. (Eagle-Picher has not accepted our calculation of the number of
      shares owed, and claims that an additional 155,279 may be due. We are
      continuing to discuss this with Eagle-Picher.) We paid the warrants to
      Eagle-Picher in consideration of its obligation to deliver 200 kilograms
      of silicon-28 to us. If Eagle-Picher does not deliver the full 200
      kilograms to us by December 31, 2000, the shares held pursuant to the
      exercise of the

                                       46

      warrants will be proportionately reduced. The principal executive offices
      of Eagle-Picher Technologies, LLC are located at 250 East Fifth Street,
      Suite 500, Cincinnati, Ohio 45202.

    The Series A Convertible Preferred Stock ("Series A Stock") consists of
1,830,000 shares issued with a liquidation preference and conversion right of
$1.50 per share. The Series A Stock is entitled to dividends or distributions
equal to the amount of the dividend or distribution per share of Common Stock
payable at such time multiplied by the number of shares of Common Stock then
obtainable upon conversion of such Series A Stock. The Redemption Trigger Date
for the Series A Stock shall be the business day immediately following the
thirtieth consecutive trading day that the average closing price during such
trading days (or, if no closing price is reported, the average of the bid and
ask prices) of the shares of Common Stock was above $8.00 per share (which
minimum price shall be proportionally adjusted for stock splits, stock
dividends, reverse stock splits and any other subdivision or combination of the
Common Stock). After the Redemption Date, we may redeem all or any part of the
Series A Stock at our election at any time and from time to time. The Series A
Stock is convertible into Common Stock at the option of the holder until we, if
at all, choose to redeem such shares on the basis of one share of Common Stock
per share of Series A Stock and, until converted, each share of Series A Stock
is entitled to one vote at any meeting of the shareholders of Isonics.

    We know of no arrangement, the operation of which may, at a subsequent date,
result in change in control of Isonics.

            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

SECTION 16(a) DISCLOSURE

    Section 16(a) of the Securities Exchange Act of 1934 (the "1934 Act")
requires Isonics' directors, executive officers and persons who own more than
ten percent of a registered class of Isonics' equity securities, to file with
the SEC initial reports of ownership and reports of changes in ownership of
Common Stock and other equity securities of Isonics. Officers, directors and
greater than ten percent shareholders are required by SEC regulation to furnish
Isonics with copies of all Section 16(a) forms they file.

    To our knowledge, based solely on a review of the copies of such reports
furnished to our and written representations that no other reports were
required, during the fiscal year ended April 30, 1999, and subsequently, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than ten percent beneficial owners were complied with exception (or in
addition) to the following:

      1. Mr. Rubizhevsky filed a Form 4 in February 2000 reporting a purchase
         that took place in July 1999. Mr. Rubizhevsky also filed a Form 4 after
         April 10, 2000 to report a sale of 1,000 shares made in March 2000.

      2. Mr. Parker filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became a director of
         Isonics in August 1998.

      3. Dr. Cuttriss and his affiliate, Metallurgy International, Inc., jointly
         filed a Form 3 in February 2000. Dr. Cuttriss became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in May 1998. A joint filing of two Form 4s was also
         made in February 2000 reporting transactions that occurred in
         July 1999 and September 1999, which Dr. Cuttriss amended in May 2000.

      4. Mr. Halstead filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in March 1999.

      5. Dr. Burden filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in January 1999. Dr. Burden also filed a Form 4 in
         February 2000 reporting a purchase that took place in July 1999.
         Dr. Burden filed a Form 4 after April 10, 2000, reporting an exercise
         of warrants that occurred in March 2000.

                                       47

      6. Mr. Herbert Hegener filed a Form 3 in February of 2000. He became
         subject to the Section 16(a) reporting requirements when he became an
         executive officer of Isonics' subsidiary, Chemotrade, Inc., in
         June 1998. Mr. Hegener filed a Form 4 in February 2000, reporting a
         warrant acquired in June 1999.

      7. Eagle-Picher Technologies, LLC became subject to the Section 16(a)
         reporting requirements when it became a greater than 10% beneficial
         owner in December of 1999. Eagle Picher filed a Form 3 in March 2000.
         Eagle-Picher exercised warrants in March 2000 but, to our knowledge has
         not yet filed a Form 4 reporting the exercise; Eagle-Picher has also
         not yet filed an amendment to its Schedule 13D reporting this exercise.

      8. Mr. Paul Catuna, a former executive officer of Isonics, was subject to
         the reporting requirements of Section 16(a) of the 1934 Act during the
         course of his employment. Mr. Catuna has filed a Form 4 in
         February 2000, reporting a stock bonus received in January 1999.

      9. Mr. Wells filed a Form 4 after April 10, 2000, reporting that an
         affiliated entity exercised warrants in March 2000.

     10. Ms. Gardner exercised warrants in March 2000, but has not yet filed a
         Form 4 reporting that exercise. Ms. Gardner has advised Isonics that
         she will file that Form 4 in May 2000.

    In addition to the foregoing, several directors and executive officers filed
Form 4s in February 2000, which voluntarily reported the acquisition of certain
Common Stock options that are exempt from the reporting requirements pursuant to
Rule 16b-3.

    (a) Mr. Alexander voluntarily filed three Form 4s in February 2000 reporting
       transactions that took place in January, April, and December of 1999. The
       Board of Directors approved the January and April transactions in minutes
       effective October 31,1999.

    (b) Mr. Rubizhevsky voluntarily filed two Form 4s in February 2000 reporting
       transactions that took place in January and April 1999. The January and
       April transactions were approved by the Board of Directors in minutes
       effective October 31,1999.

    (c) Ms. Gardner voluntarily filed one Form 4 in February 2000 reporting
       transactions that took place in May and October of 1998.

    (d) Mr. Parker voluntarily filed a Form 4 in February 2000 reporting
       transactions that occurred in October 1998.

    (e) Mr. Halstead voluntarily filed two Form 4s in February 2000 reporting
       transactions that took place in April 1999 and in January 2000. The Board
       of Directors approved these transaction in minutes effective
       October 31,1999, and January 30, 2000.

    (f) Dr. Burden voluntarily filed one Form 4 in February 2000 reporting a
       transaction that took place in April 1999. The Board of Directors
       approved this transaction in minutes effective October 31,1999.

    (g) Dr. Grady voluntarily filed two Form 4s in February 2000 reporting
       transactions that took place in January and April 1999 and were approved
       by the Board of Directors in minutes effective October 31,1999.

SHORT-SWING LIABILITY

    On behalf of Metallurgy International, Inc., an affiliate of Dr. Cuttriss,
but without authorization from Dr. Cuttriss or Isonics, a broker-dealer sold and
purchased shares in July and September of 1999 respectively. With authorization
from Dr. Cuttriss and Isonics, Metallurgy International sold additional

                                       48

shares in February and March 2000. As a result, Isonics raised the concern that
Dr. Cuttriss may have obtained a short-swing profit which Dr. Cuttriss
satisfied, subject to further review after consultation with his personal
counsel. Isonics has received an opinion of counsel, which reached the
conclusion that "a court would likely not impose liability on [Dr.] Cuttriss for
the unauthorized July 1999 and September 1999 transactions under Section 16(b)
of the Securities Exchange Act of 1934."

                             EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

    The following table sets forth information regarding compensation awarded,
paid to, or earned by the chief executive officer and the other principal
officers of Isonics for the three years ended April 30, 1997, 1998, and 1999. No
other person who is currently an executive officer of Isonics earned salary and
bonus compensation exceeding $100,000 during any of those years. This includes
all compensation paid to each by Isonics and any subsidiary.



                                                                                       LONG-TERM
                                                                                  COMPENSATION AWARDS
                                                                         -------------------------------------
                                                                                 AWARDS                PAYOUT
                                                                         -----------------------      --------
                                          ANNUAL COMPENSATION                         SECURITIES
                                     ------------------------------         ($)       UNDERLYING
NAME AND                   FISCAL      ($)        ($)        ($)         RESTRICTED   OPTIONS &         LTIP      ALL OTHER
PRINCIPAL POSITION          YEAR      SALARY     BONUS     OTHER(A)        AWARDS      SARS (#)        PAYOUT    COMPENSATION
- ------------------        --------   --------   --------   --------      ----------   ----------      --------   ------------
                                                                                         
James E. Alexander......    1997     174,000          0           0            0               0          0             0
  President & CEO           1998     204,870          0      60,553(b)         0               0          0             0
                            1999     200,000     50,000      35,016(b)         0          25,000(e)       0             0
                            2000     212,000    199,092      12,737            0               0          0             0

Boris Rubizhevsky.......    1997     147,000          0           0            0               0          0             0
  Senior Vice President     1998     176,975          0      25,946(b)         0               0          0             0
                            1999     184,100     45,000      25,404(b)         0          22,500(f)       0             0
                            2000     191,000    162,675      13,180            0               0          0             0

Daniel J. Grady.........    1997     107,000          0           0            0               0          0             0
  Vice President            1998     125,603          0           0            0               0          0             0
                            1999     127,188     16,000           0            0          15,625(g)       0             0
                            2000     125,000     22,291      11,813            0               0          0             0

Stephen J. Burden.......    1997         N/A        N/A         N/A          N/A          71,459(h)     N/A           N/A
  Vice President(c)         1998         N/A        N/A         N/A          N/A             N/A        N/A           N/A
                            1999           0          0           0            0         121,458(i)       0             0
                            2000     125,000     15,902       7,550            0               0          0             0

Robert H. Cuttriss......    1997         N/A        N/A         N/A          N/A             N/A        N/A           N/A
  President of
  Interpro(d)               1998         N/A        N/A         N/A          N/A             N/A        N/A           N/A
                            1999      92,872     80,000           0            0          20,000(j)       0             0
                            2000     104,815          0       3,144            0               0          0             0


- ------------------------

(a) Excludes other compensation, the aggregate amount of which does not exceed
    the lesser of $50,000 or 10% of such named Executive Officers' annual
    compensation.

(b) Mr. Alexander's amounts represent $35,016 for interest and taxes payable as
    a result of a loan in fiscal year 1999, and $60,553 for interest and taxes
    payable as a result of a loan in fiscal year 1998. Mr. Rubizhevsky's amounts
    represent $25,404 for interest and taxes payable as a result of a loan in
    fiscal year 1999, and $25,946 for interest and taxes payable as a result of
    a loan in fiscal year 1998.

(c) Dr. Burden became an officer of Isonics effective January 1999.

                                       49

(d) Interpro was acquired effective April 30, 1998. Prior to May 1, 1998,
    Dr. Cuttriss was not an Isonics employee. The bonus paid to Dr. Cuttriss in
    fiscal year 1999 was for back pay accrued prior to the acquisition of
    Interpro by Isonics.

(e) Options to purchase 25,000 shares of Common Stock were granted in
    April 1999 as consideration for delaying salary in March and April 1999, and
    are currently exercisable at $1 7/16 per share and expire April 26, 2004.

(f) Options to purchase 22,500 shares of Common Stock were granted in
    April 1999 as consideration for delaying salary in March and April 1999, and
    are currently exercisable at $1 7/16 per share and expire April 26, 2004.

(g) Options to purchase 15,625 shares of Common Stock were granted in
    April 1999 as consideration for delaying salary in March and April 1999, and
    are currently exercisable at $1 7/16 per share and expire April 26, 2004.

(h) Options to purchase 71,429 shares of Common Stock were granted upon
    beginning employment with Isonics (of which 46,425 have vested as of
    April 30, 2000, and continue to vest at a rate of 5% per quarter) in
    January 1997. Dr. Burden was not an executive officer at the time of this
    award. Dr. Burden became an executive officer in January 1999.

(i) Options to purchase 100,000 shares of Common Stock were granted in
    January 1999 as consideration for Dr. Burden's promotion to vice president
    in January 1999, with an exercise price of $1.10 per share (of which 45,000
    have vested as of April 30, 2000, and continue to vest at a rate of 5% per
    quarter). Options to purchase 21,458 shares of Common Stock were granted in
    April 1999 as consideration for delaying salary in March and April 1999, and
    are currently exercisable at $1 7/16 per share and expire April 26, 2004.

(j) Options granted in May 1998 in connection with the acquisition of Interpro
    by Isonics are currently exercisable at $2.00 per share and expire May 1,
    2003.

    In October 1996, we adopted an employee benefit plan under Internal Revenue
Code Section 401(k). The 401(k) plan is a profit sharing plan under which both
employees and Isonics are entitled (at their own discretion) to contribute a
portion of compensation and earnings, respectively, to investment funds to
supplement employee retirement benefits. On November 1, 1999, the Isonics
Corporation 401(k) plan was merged with the Interpro 401(k) plan.

    We do not have written plans to pay bonuses or deferred compensation to our
employees except those expressly stated in the following sections.

    We have adopted medical, dental, and life insurance plans for our employees
and their dependents at our cost. In some cases, we also provide discretionary
disability and other insurance plans for the benefit of our employees.

EMPLOYMENT AGREEMENTS, TERMINATION OF EMPLOYMENT AND CHANGE IN CONTROL
  AGREEMENTS

    In September 1997, we entered into employment agreements with James E.
Alexander and Boris Rubizhevsky. The agreements have a term of four years and
provide for annual salaries of $200,000 and $180,000, respectively, although
either Isonics or the individuals may terminate these agreements prematurely in
their discretion. By resolution of the Board made on January 30, 2000, both
Mr. Alexander and Mr. Rubizhevsky received salary increases commencing
February 1, 2000, equal to 20% of their then current salary. The salary
increases were granted in recognition of their performance for Isonics and the
fact that neither Mr. Alexander nor Mr. Rubizhevsky had received salary
increases in approximately two and one-half years. Under the agreements, the
officer is entitled to receive incentive compensation up to 50% of the officer's
annual salary, as approved by Isonics pursuant to such executive compensation
plan as Isonics may approve. The agreements provide that upon a

                                       50

termination of employment other than for cause (as defined in the agreements),
the officer is entitled to severance compensation of 18 months of his salary,
paid at the same time as salary payments, 25% of the officer's annual prevailing
salary, paid upon termination, and in addition all outstanding stock options
held by the officer will be accelerated and will become exercisable in full and
our right of repurchase will terminate with respect to such shares. The
agreements provide for similar accelerated vesting of outstanding stock options
upon a change in control of Isonics.

    We have also entered into employment agreements with Dr. Daniel J. Grady and
Dr. Stephen J. Burden. The agreements have an indefinite term and provides for
at-will employment, terminable at any time by either party. The agreements
provide for a rate of annual compensation, which we will review annually. Under
the each agreement, Dr. Grady and Dr. Burden are entitled to participate in our
standard plans and policies. The agreements also include confidentiality and
invention assignment provisions. Additionally, Mr. Herbert Hegener and
Dr. Robert Cuttriss are covered by an employment agreements extending through
the September 2001 and September 2003, respectively.

    Mr. Brantley J. Halstead was hired as Chief Financial Officer in
March 1999. Mr. Halstead has entered into an employment agreement with us. The
agreement has an indefinite term and provides for at-will employment, terminable
at any time by either party. The agreement provides for a rate of annual
compensation of $96,000, which we will review annually. Under the agreement,
Mr. Halstead is entitled to participate in our standard plans and policies. The
agreement also includes confidentiality and invention assignment provisions.

STOCK OPTIONS AND OPTION PLANS

    We grant options to executive officers, employees and consultants under the
following plans (collectively the "Plans"):

    (a) 1996 Stock Option Plan which has been terminated, but as to which, there
       are options outstanding.

    (b) 1996 Executives' Equity Incentive Plan (the "Executives' Plan")
       authorized the grant of options to purchase 225,000 stock options, which
       after being adjusted for stock splits that occurred following the
       adoption of the plan resulted in 570,000 shares. The options granted may
       be either incentive stock options if they meet the requirements of
       Section 422 of the Internal Revenue Code, or non-qualified stock options.
       The directors approved this plan in September 1996 and the shareholders
       in October 1996.

    (c) 1996 Equity Incentive Plan (the "Employees' Plan") authorized the grant
       of options to purchase 50,000 stock options, which after being adjusted
       for stock splits that occurred following the adoption of the plan
       resulted in 150,000 shares. The options granted may be either incentive
       stock options if they meet the requirements of Section 422 of the
       Internal Revenue Code, or non-qualified stock options. The directors
       approved this plan in September 1996 and the shareholders in
       October 1996.

    (d) 1998 Employee Stock Purchase Plan (the "Stock Purchase Plan") authorized
       employee purchase of up to 200,000 shares of Isonics Common Stock. The
       directors approved this plan in August 1998, and the shareholders in
       October 1998.

    As of June 12, 2000, options to purchase a total of 365,583 shares, 104,500
shares, and 358,769 shares respectively, were outstanding under the Executives'
Plan, Employees' Plan, and 1996 Stock Option Plan, and options to purchase
189,417, 9,862, and 0 shares, respectively, remained available for grant.

    We have not adopted any other stock option or stock appreciation rights
plan.

                                       51

                     OPTIONS/SAR GRANTS IN LAST FISCAL YEAR

    The following options were granted to executive officers named in the
compensation table during the fiscal year ended April 30, 1999. We did not grant
any stock appreciation rights to any person during fiscal year 1999 or
subsequently. There was no exercise of options or SARs during the fiscal year
ended April 30, 1999.



                                             NUMBER OF       PERCENT OF
                                             SECURITIES    TOTAL OPTIONS/
                                             UNDERLYING     SARS GRANTED
NAME AND                                    OPTIONS/SARS    TO EMPLOYEES    EXERCISE PRICE    EXPIRATION
PRINCIPAL POSITION                          GRANTED (#)    IN FISCAL YEAR       ($/SH)           DATE
- ------------------                          ------------   --------------   --------------   ------------
                                                                                 
James E. Alexander .......................      25,000              7.1%        1$7/16        April 2004
  President & CEO

Boris Rubizhevsky ........................      22,500              6.3%        1$7/16        April 2004
  Senior Vice President

Daniel J. Grady ..........................      15,625              4.4%        1$7/16        April 2004
  Vice President

Stephen J. Burden ........................      21,458                          1$7/16        April 2004
  Vice President                               100,000             33.9%         $1.10       January 2004

Robert H. Cuttriss .......................      20,000              5.6%         $2.00        April 2003
  President of Interpro


   AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR END OPTION
                                     VALUES

    No officer exercised employee stock options during the fiscal year ended
April 30, 1999, or subsequently. The following table sets forth information
regarding the year-end value of options being held by the Chief Executive
Officer and the other such named officers and persons on April 30, 1999.



                                                              NUMBER OF SECURITIES        VALUE OF UNEXERCISED
                                                             UNDERLYING UNEXERCISED           IN-THE-MONEY
                                                                  OPTIONS/SARS                OPTIONS/SARS
NAME AND                       SHARES ACQUIRED    VALUE         AT APRIL 30, 1999           AT APRIL 30, 1999
PRINCIPAL POSITION             ON EXERCISE (#)   REALIZED   EXERCISABLE/UNEXERCISABLE   EXERCISABLE/UNEXERCISABLE
- ------------------             ---------------   --------   -------------------------   -------------------------
                                                                            
James E. Alexander ..........         0             0            25,000/0                  $53,125.00/$0.00
  President & CEO(a)

Boris Rubizhevsky ...........         0             0            22,500/0                  $47,812.50/$0.00
  Senior Vice President(a)(b)

Daniel J. Grady .............         0             0            222,965/0                $651,851.78/$0.00
  Vice President(a)

Stephen J. Burden ...........         0             0         78,599/114,288              $166,991/$257,822
  Vice President

Robert H. Cuttriss ..........         0             0            20,000/0                     $31,350/$0
  President of Interpro


- ------------------------

(a) Does not include 45,455 shares of Common Stock awarded to Mr. Alexander,
    36,364 shares of Common Stock awarded to Mr. Rubizhevsky, and 14,545 shares
    of Common Stock awarded to Dr. Grady in January 1999. These were stock
    grants and not grants of stock options.

(b) Does not include 33,333 warrants obtained in a private transaction completed
    in July 1999.

                                       52

LONG TERM INCENTIVE COMPENSATION PLANS, AND DEFINED BENEFIT AND ACTUARIAL PLANS

    Isonics has no long term incentive compensation plans, defined benefit
plans, or actuarial plans.

COMPENSATION OF DIRECTORS

    The directors of Isonics were not compensated for their services during
fiscal year 1999, or subsequently during calendar year 1999. However, each
director was reimbursed for travel and related expenses associated with Board of
Directors' meetings. In January 2000, it was agreed to compensate non-employee
directors $2,000 for attending Board of Directors' meetings in person and $500
for attending Board of Directors' meetings telephonically beginning January 1,
2000.

    The 1998 Directors' Plan (the "Directors' Plan") authorized each person
serving as a member of the Board who is not an employee of Isonics to receive
options to purchase 20,000 shares of Isonics Common Stock when such person
accepts his position as a Director and to receive an additional option to
purchase 10,000 shares when such person is re-elected as a Director provided
such person is not an employee of Isonics. The exercise price for the options is
the Fair Market Value (as defined in the Executives' Plan) on the date such
person becomes a director and the options are exercisable for five years from
such date. The options granted under the Directors' plan vest immediately upon
the date of the grant. In the event a Director resigns or is not re-elected to
the Board, failure to exercise the options in three months results in the
options' termination prior to the expiration of their term. Although the
Directors adopted the plan in 1998, the Board formalized the plan by resolution
in January 2000.

    Under the Directors' Plan the following individuals have been granted
options:

    (a) On May 21, 1998, Lindsay Gardner received 20,000 options exercisable at
       $2.3750 per share through May 21, 2003.

    (b) On August 1, 1998, Richard Parker received 20,000 options exercisable at
       $1.65 per share through August 1, 2003.

    (c) On October 5, 1998, as a result of their re-election to the Board of
       Directors Ms. Gardner and Mr. Parker each received options to acquire an
       additional 10,000 shares exercisable at $1.1875 per share through
       October 5, 2003.

    (d) On January 30, 2000, Larry J. Wells received 20,000 options exercisable
       at $7.3125 per share through January 29, 2005.

    (e) On April 26, 2000, following their re-election as directors at our
       annual meeting of shareholders, we granted options to purchase 10,000
       shares to each of Ms. Gardner and Messrs. Parker and Wells. These options
       are exercisable at $6.125 per share through April 26, 2005.

    As of April 30, 2000, options to purchase a total of 110,000 shares were
outstanding under the Directors Plan. We do not have any other arrangements
pursuant to which it compensates the Directors for acting in their capacities as
such.

                                       53

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

    The following sets out information regarding transactions between officers,
directors and significant shareholders of Isonics during the most recent two
fiscal years and during the subsequent fiscal year.

CORPORATE LOANS TO OFFICERS

    During the fiscal years ended April 30, 1998 and 1999, we had loans
outstanding to two officers. The funds had been advanced to the officers to
allow them to exercise options prior to our Initial Public Offering. The options
were exercised in September 1996, in part, to allow us to establish a pool of
shares available for future awards pursuant to the Plans in amounts that comply
with the guidelines established by certain state blue sky authorities. Interest
was charged on these loans at a rate of 6.6% per annum. In minutes effective
October 31, 1999 and January 30, 2000, the Board of Directors agreed to forgive
a portion of the current interest and principal due and to accept Isonics Common
Stock, owned by the officers, in payment of the remaining balance owed. The
amount owed by Mr. Alexander, that was forgiven by the Board of Directors, in
October 1999, was $74,038.54. The amount owed by Mr. Rubizhevsky, that was
forgiven by the Board of Directors, in October 1999, was $60,534.23. In both
cases the amount forgiven was treated as bonus compensation to Mr. Alexander and
Mr. Rubizhevsky. Both officers surrendered 30,437 shares of Isonics Common Stock
each to pay off $175,012.33 in accumulated interest and principal ($10,012.33 in
interest and $165,000.00 in principal each). As of April 30, 2000 we had no
loans receivable outstanding with our officers or employees. Please refer to the
following schedule.



                                            JAMES E. ALEXANDER     BORIS RUBIZHEVSKY
                                             PRESIDENT & CEO     SENIOR VICE PRESIDENT
                                            ------------------   ---------------------
                                                           
Balance as of May 1, 1997.................      $198,570.46           $167,570.46
FY 1998 Borrowings(a).....................        86,662.35             59,812.86
FY 1998 Repayments(a).....................        53,207.42              4,040.88
                                                -----------           -----------
Balance as of April 30, 1998..............      $232,025.39           $223,342.44
FY 1999 Borrowings(a).....................         8,360.78              3,750.51
FY 1999 Repayments(a).....................         4,025.79              3,767.73
                                                -----------           -----------
Balance as of April 30, 1999..............      $236,360.38           $223,325.22
FY 2000 Borrowings(a).....................         7,690.49              7,221.34
FY 2000 Repayments(a).....................       244,050.87            230,546.56
                                                -----------           -----------
Balance as of April 30, 2000..............      $      0.00           $      0.00


- ------------------------

(a) Includes interest accrued and paid. Amounts are aggregated.

                                       54

CORPORATE LOANS FROM OFFICERS AND EMPLOYEES

    On occasion during the fiscal years ended April 30, 1998 and 1999, officers
and employees of Isonics loaned Isonics funds. The following schedule summarizes
these borrowing and repayments.



NAME AND                                   BALANCE AS OF      FY 1998         FY 1998      BALANCE AS OF
PRINCIPAL POSITION                          MAY 1, 1997    BORROWINGS(A)   REPAYMENTS(A)   APRIL 30, 1998
- ------------------                         -------------   -------------   -------------   --------------
                                                                               
James E. Alexander ......................   $      0.00     $ 25,000.00     $ 25,000.00        $0.00
  President & CEO

Boris Rubizhevsky .......................   $      0.00     $      0.00     $      0.00        $0.00
  Senior Vice President

Daniel J. Grady .........................   $      0.00     $ 15,600.00     $ 15,600.00        $0.00
  Vice President

Stephen J. Burden .......................   $      0.00     $ 86,821.92     $ 86,821.92        $0.00
  Vice President(b)

Lindsay Gardner .........................   $      0.00     $122,880.28     $122,880.28        $0.00
  Director(c)

Jacques J. Delente(d) ...................   $150,000.00     $ 13,020.55     $163,020.55        $0.00


- ------------------------

(a) Includes interest accrued and paid through April 30, 1998. Amounts are
    aggregated.

(b) Dr. Burden was also granted warrants exercisable for 40,951 shares of Common
    Stock issued in connection with a private placement (the "Placement I") of
    12% nonconvertible promissory notes and warrants to purchase Isonics Common
    Stock in September 1997.

(c) Ms. Gardner was also granted warrants exercisable for 91,001 shares of
    Common Stock issued in connection with Placement I of 12% nonconvertible
    promissory notes and warrants to purchase Isonics Common Stock in
    September 1997.

(d) Dr. Delente was also granted warrants exercisable for 122,853 shares of
    Common Stock issued in connection with Placement I of 12% nonconvertible
    promissory notes and warrants to purchase Isonics Common Stock in
    September 1997.



                                            BALANCE AS OF      FY 1999         FY 1999       BALANCE AS OF
NAME AND PRINCIPAL POSITION                  MAY 1, 1998    BORROWINGS(A)   REPAYMENTS(A)   APRIL 30, 1999
- ---------------------------                 -------------   -------------   -------------   ---------------
                                                                                
James E. Alexander .......................      $0.00        $     0.00       $     0.00       $     0.00
  President & CEO

Boris Rubizhevsky ........................      $0.00        $44,290.20       $     0.00       $44,290.20
  Senior Vice President

Daniel J. Grady ..........................      $0.00        $47,100.00       $47,100.00       $     0.00
  Vice President

Stephen J. Burden ........................      $0.00        $     0.00       $     0.00       $     0.00
  Vice President

Lindsay Gardner ..........................      $0.00        $     0.00       $     0.00       $     0.00
  Director

Jacques J. Delente........................      $0.00        $93,000.00       $48,000.00       $45,000.00


- ------------------------

(a) Includes interest accrued and paid through April 30, 1999. Amounts are
    aggregated.

                                       55




                                            BALANCE AS OF      FY 2000         FY 2000       BALANCE AS OF
NAME AND PRINCIPAL POSITION                  MAY 1, 1999    BORROWINGS(A)   REPAYMENTS(A)   APRIL 30, 2000
- ---------------------------                 -------------   -------------   -------------   ---------------
                                                                                
James E. Alexander .......................   $     0.00      $     0.00       $     0.00       $     0.00
  President & CEO

Boris Rubizhevsky ........................   $44,290.20      $ 8,858.04       $53,214.24       $     0.00
  Senior Vice President(b)

Daniel J. Grady ..........................   $     0.00      $     0.00       $     0.00       $     0.00
  Vice President

Stephen J. Burden ........................   $     0.00      $57,500.00       $57,500.00       $     0.00
  Vice President(c)

Lindsay Gardner ..........................   $     0.00      $     0.00       $     0.00       $     0.00
  Director

Jacques J. Delente........................   $45,000.00      $13,500.00       $58,500.00       $     0.00


- ------------------------

(a) Includes interest accrued and paid through April 30, 2000. Amounts are
    aggregated.

(b) Mr. Rubizhevsky's note to Isonics was converted into 66,666 shares of Common
    Stock underlying 33,333 shares of Series A Convertible Preferred Stock and
    33,333 warrants issued in connection with a second private placement (the
    "Placement II") of Series A Convertible Preferred Stock and warrants to
    purchase Isonics Common Stock on July 30, 1999.

(c) Dr. Burden's note to Isonics was converted into 66,666 shares of Common
    Stock underlying 33,333 shares of Series A Convertible Preferred Stock and
    33,333 warrants issued in connection with Placement II on July 30, 1999.

    Mr. Hegener had a loan payable to him from Isonics in the amount of $438,314
resulting from the 1998 purchase of Chemotrade by Isonics. Isonics issued to
Mr. Hegener 35,000 warrants to purchase Common Stock at $3.00 per share through
June 30, 2004 to compensate him for a late loan payment.

                             ISONICS' CAPITAL STOCK

    Our authorized capital stock consists of 20,000,000 shares of Common Stock
and 10,000,000 shares of Preferred Stock. As of June 12, 2000, there were
outstanding 10,792,160 shares of Common Stock and 1,696,667 shares of Series A
Convertible Preferred Stock. Subsequent to the date of this prospectus,
shareholders converted 180,000 shares of Series A Convertible Preferred Stock
into 180,000 shares of our Common Stock. As of June 21, 2000, there were
outstanding 10,972,160 shares of Common Stock and 1,516,667 shares of Series A
Convertible Preferred Stock. As of June 21, 2000, there were also outstanding
options issued pursuant to our employee benefit plans to purchase a total of
938,852 shares, and other options and warrants to purchase a total of 3,926,647
shares of Common Stock. The number of outstanding shares includes 3,130,435
shares issued to Eagle-Picher pursuant to an exercise of a warrant to purchase
4,000,000; these shares are subject to forfeiture to the extent that
Eagle-Picher does not deliver 200 kilograms of silicon-28 meeting certain
specifications to Isonics by December 31, 2000. As discussed above, Eagle-Picher
believes that we should issue it an additional 155,279 shares, although we
dispute this calculation and we are continuing to discuss this matter.

COMMON STOCK

    Subject to preferences that may be applicable to any Preferred Stock
outstanding at the time, the holders of outstanding shares of Common Stock are
entitled to receive dividends out of assets legally available therefor at such
times and in such amounts as the Board of Directors may from time to time
determine.

    Each shareholder is entitled to one vote for each share of Common Stock held
on all matters submitted to a vote of shareholders.

                                       56

    Cumulative voting for the election of directors is specifically authorized
by the Bylaws. Under cumulative voting for the election of directors, upon a
proper and timely request by a shareholder, each shareholder is entitled to cast
a number of votes equal to the number of shares held multiplied by the number of
directors to be elected. The votes may be cast for one or more candidates. Thus,
under cumulative voting, a majority of the outstanding shares will not
necessarily be able to elect all of the directors, and minority shareholders may
be entitled to greater voting power with respect to election of directors than
if cumulative voting did not apply.

    The Bylaws provide that so long as we are a "listed company" as defined by
applicable California law, there will not be cumulative voting in connection
with the election of directors. At the present time, we are not a "listed
company" as defined in California law, and therefore cumulative voting will
continue to apply in connection with the election of directors.

    The Common Stock is not entitled to preemptive rights and is not subject to
conversion or redemption. Upon liquidation, dissolution or winding up of
Isonics, the remaining assets legally available for distribution to
shareholders, after payment of claims or creditors and payment of liquidation
preferences, if any, on outstanding Preferred Stock, are distributable ratably
among the holders of the Common Stock and any participating Preferred Stock
outstanding at that time. Each outstanding share of Common Stock is fully paid
and nonassessable.

PREFERRED STOCK

    The Board of Directors is authorized, subject to any limitations prescribed
by California law, to provide for the issuance of shares of Preferred Stock in
one or more series, to establish from time to time the number of shares to be
included in each such series, to fix the rights, preferences and privileges of
the shares of each unissued series and any qualifications, limitations or
restrictions thereon, and to increase or decrease the number of shares of any
such series (but not below the number of shares of such series then
outstanding), without any further vote or action by the shareholders. The Board
of Directors may authorize the issuance of Preferred Stock with voting or
conversion rights that could adversely affect the voting power or other rights
of the holders of Common Stock. Thus, the issuance of Preferred Stock may have
the effect of delaying, deferring or preventing a change in control of Isonics.

    We have issued 1,830,000 shares of our Series A Convertible Preferred Stock.
This Preferred Stock may be converted to common shares of Isonics stock at a
fixed conversion price of $1.50 per share, which would result in the exchange of
one share of Common Stock for each share of Series A Convertible Preferred
Stock. This conversion ratio is subject to dilution adjustments. The Series A
Convertible Preferred Stock is entitled to receive dividends on a
share-for-share basis with the shares of Common Stock except in the case of a
"Silicon Isotope Transaction" as defined in the Certificate of Determination
that was filed with the California Secretary of State to create the Series A
Convertible Preferred Stock. If a "Silicon Isotope Transaction" occurs, the
holders of Series A Convertible Preferred Stock have certain additional rights.
The Series A Convertible Preferred Stock is entitled to a liquidation preference
of $1.50 per share.

CLASS A WARRANTS

    Class A Warrants to purchase Common Stock were issued in September 1997 and
are registered pursuant to Section 12(g) of the Securities Exchange Act of 1934,
as amended. The following is a brief summary of certain provisions of the
Warrants.

    We issued Class A Warrants to purchase an aggregate of 810,000 shares of
Common Stock. We have also reserved 810,000 shares for issuance upon exercise of
the Class A Warrants. Each Class A Warrant entitles the registered holder
thereof to purchase one share of Common Stock at a price of

                                       57

$5.80, subject to adjustment, through September 21, 2001. After expiration, the
Warrants will be void and of no value.

    We may redeem the Warrants at a price of $0.10 per Warrant on not less than
30 days' prior written notice if the average of the last reported bid and asked
prices of the Common Stock (if the Common Stock is then traded in the
over-the-counter market) or the last reported sale price of the Common Stock (if
the Common Stock is then traded on a national securities exchange or the Nasdaq
National Market or SmallCap Market) has been at least $14.50 per share (subject
to adjustment) for at least 20 consecutive trading days ending within three days
prior to the date on which notice of redemption is given.

    The Warrants contain provisions that protect the holders thereof against
dilution by adjustment of the exercise price and number of shares issuable upon
exercise, on the occurrence of certain events, such as stock dividends, stock
splits and recapitalizations. We are not required to issue fractional shares. In
lieu of the issuance of such fractional shares, we will pay cash to such holders
of the Warrants. In computing the cash payable to such holders, a share of
Common Stock will be valued at its price immediately prior to the close of
business on the expiration date. The holder of a Warrant will not possess any
rights as a shareholder of Isonics unless such shareholder exercises such
Warrant.

CLASS B WARRANTS AND CLASS C WARRANTS

    No Class B Warrants have yet been issued, but they will be issued to holders
of our Class A Warrants who accept the exchange offer.

    No Class C Warrants have yet been issued, but they will be issued to persons
who exercise their Class A Warrants prior to the expiration of the exchange
offer, or who exercise their Class B Warrants prior to their expiration. The
Class C Warrants will also be registered pursuant to Section 12(g) of the
Securities Exchange Act of 1934, as amended.

    The Class B Warrants and the Class C Warrants contain provisions that
protect the holders thereof against dilution by adjustment of the exercise price
and number of shares issuable upon exercise, on the occurrence of certain
events, such as stock dividends, stock splits and recapitalizations. We are not
required to issue fractional shares. In lieu of the issuance of such fractional
shares, we will pay cash to such holders of the Warrants. In computing the cash
payable to such holders, a share of Common Stock will be valued at its price
immediately prior to the close of business on the expiration date. The holder of
a Warrant will not possess any rights as a shareholder of Isonics unless such
shareholder exercises such Warrant.

    The material terms and conditions of the Class B Warrants and the Class C
Warrants are summarized above. SEE "THE EXCHANGE OFFER."

                                       58

            MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

    On September 22, 1997, our Units (consisting one share of Common Stock and
one Class A Warrant) started trading on the Over The Counter (OTC) Bulletin
Board under the symbol ISONU. In October 1997, we unbundled the Units and the
Common Stock and Class A Warrants commenced trading on the OTC Bulletin Board
under the symbols ISON and ISONW, respectively.

    The following table sets forth the high and low bid prices for the Common
Stock and the Class A Warrants (quotations reflect inter-dealer prices, without
retail mark-up, mark-down or commission and may not represent actual
transactions) from September 22, 1997 through April 30, 2000 as reported by OTC
Bulletin Board.



                                                       QUARTER ENDED
                               -------------------------------------------------------------
                               JULY 31, 1999   OCT. 31, 1999   JAN. 31, 2000   APR. 30, 2000
                               -------------   -------------   -------------   -------------
                                                                   
Common Stock (ISON)
  High.......................   3 5/8            2 1/8          10 1/2          17 15/16
  Low........................   1 7/8            7/8            1               5 9/16

Class A Warrants (ISONW)
  High.......................    13/16          1/2            3 15/16        13 5/8
  Low........................    1/2            3/16           1/4            3




                                                       QUARTER ENDED
                               -------------------------------------------------------------
                               JULY 31, 1998   OCT. 31, 1998   JAN. 31, 1999   APR. 30, 1999
                               -------------   -------------   -------------   -------------
                                                                   
Common Stock (ISON)
  High.......................   2 23/32         1 29/32         2               3 9/16
  Low........................   1 21/32         1 1/32           25/32         1 7/16

Class A Warrants (ISONW)
  High.......................    3/4            7/16           3/8            3/4
  Low........................    9/32           3/16           3/32           9/32




                                                       QUARTER ENDED
                               -------------------------------------------------------------
                               JULY 31, 1997   OCT. 31, 1997   JAN. 31, 1998   APR. 30, 1998
                               -------------   -------------   -------------   -------------
                                                                   
Common Stock (ISON)
  High.......................           --      8 3/8               5 5/8      3
  Low........................           --      5 1/2                1/4       1 13/16

Class A Warrants (ISONW)
  High.......................           --      2 3/4               2 1/4       11/16
  Low........................           --      1 3/8                0.01       1/8


    As of June 12, 2000, there were approximately 250 holders of record of our
Common Stock. This does not include an indeterminate number of persons who hold
our Common Stock in brokerage accounts and otherwise in "street name.

    We have never declared or paid a cash dividend on our Common Stock. We
presently intend to retain our earnings to fund development and growth of our
business and, therefore, do not anticipate paying any cash dividends in the
foreseeable future. Additionally, the certificate of designation for the
Series A Convertible Preferred Stock contains restrictions on our ability to pay
dividends to holders of our Common Stock.

                                       59

                        SHARES AVAILABLE FOR FUTURE SALE

    The market price of our Common Stock could drop if substantial amounts of
shares are sold in the public market or if the market perceives that such sales
could occur. A drop in the market price could adversely affect holders of the
stock and could also harm our ability to raise additional capital by selling
equity securities. The securities that may be sold from time to time under this
prospectus represent a market overhang.

    As of June 12, 2000, we had outstanding options, warrants and convertible
securities for the purchase of up to approximately 6,562,166 shares of Common
Stock at an average price of $2.57 per share, representing approximately 37.8%
of our outstanding shares of Common Stock on a fully-diluted basis. Subsequent
to the date of this prospectus, shareholders converted 180,000 shares of
Series A Convertible Preferred Stock into 180,000 shares of our Common Stock. As
of June 21, 2000, we had outstanding options, warrants and convertible
securities for the purchase of up to approximately 6,382,166 shares of Common
Stock at an average price of $2.62 per share, representing approximately 36.8%
of our outstanding shares of Common Stock on a fully-diluted basis. The
perception that these instruments may be exercised for or converted into Common
Stock that then could be sold into the public market could adversely affect the
market price of our Common Stock. In addition, we have entered into registration
rights agreements with certain of our stockholders entitling them to include
their shares of Common Stock in registration statements for securities filed by
Isonics under the Securities Act of 1933, as amended. Awareness of the existence
of these registration rights could lead to a perception that sales of the shares
subject to the registration rights could occur, which could materially and
adversely affect our stock price or could impair our ability to obtain capital
through sales of equity securities. In addition, shares we have issued in
private transactions over the past two years will become eligible for sale in
the public market under SEC Rule 144.

    These shares are restricted securities as defined in Rule 144. Under that
rule, a stockholder who owns restricted shares that have been outstanding for at
least one year is entitled to sell, within any three-month period, a number of
restricted shares that does not exceed the greater of: (i) 1% of the then
outstanding shares of Common Stock, or approximately 107,921 shares as of
June 12, 2000 (or approximately 109,721 shares as of June 21, 2000); and
(ii) an amount equal to the average weekly trading volume in the Common Stock
during the four calendar weeks preceding the sale.

                      SECURITIES AND EXCHANGE POSITION ON
                 INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

    The Articles of Incorporation of Isonics require it to indemnify its
officers, directors, employees and agents against certain liabilities incurred
by them in those capacities if they acted in good faith and reasonably believed
their conduct was in the best interests of Isonics or not opposed to it. Isonics
is also required to indemnify a person who is or was a director, officer,
employee or agent of Isonics and who was successful, on the merits or otherwise,
in defense of any proceeding to which he was a party, against reasonable
expenses, which include attorneys' fees, incurred by him or her in connection
with the proceeding.

    Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of
Isonics under the provisions discussed in the previous paragraph, or otherwise,
Isonics has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in that
Act and is, therefore, unenforceable.

                                    EXPERTS

    The consolidated balance sheets as of April 30, 1998 and 1999, and the
consolidated statements of operations, stockholders' equity, and cash flows for
the years then ended, have been audited by Grant

                                       60

Thornton LLP, independent certified public accountants, as set forth in their
report thereon appearing elsewhere herein and in the Registration Statement, and
are included in reliance upon such report given upon the authority of such firm
as experts in accounting and auditing.

                                 LEGAL MATTERS

    Certain legal matters, including the validity of the shares of Common Stock
offered hereby, have been passed upon for Isonics by Norton-Lidstone, P.C.,
Englewood, Colorado. Norton-Lidstone, P.C., will rely as to matters of
California law on an opinion of Arter & Hadden, LLP, Los Angeles, California.

                      HOW TO OBTAIN ADDITIONAL INFORMATION

    We file annual, quarterly, proxy statements, and other information with the
Securities and Exchange Commission (the "SEC"). You may read and copy any
document we have filed with the SEC in its public reference room at 450 Fifth
Street N.W. Washington, D.C. 20549. You may obtain information on the operation
of the public reference room by calling the SEC at 1-800-432-0330. The SEC
maintains a World Wide Web site on the Internet at HTTP://WWW.SEC.GOV that
contains reports, proxy and information statements, and other information
regarding companies, including those that Isonics files electronically with the
SEC.

    We also furnish Annual Reports to our shareholders that contain audited
financial information.

    This prospectus is part of a registration statement (on Form S-4) we have
filed with the SEC relating to this exchange offer and our Common Stock
described in this prospectus. As permitted by the SEC rules, this prospectus
does not contain all of the information contained in the registration,
accompanying exhibits and schedules we file with the SEC. You may refer to the
registration, the exhibits and schedules for more information about our Company
and our Common Stock. The registration statement, exhibits, and schedules are
also available at the SEC's public reference rooms or through its EDGAR database
on the Internet.

    You should rely only on the information contained or incorporated by
reference in this prospectus. Isonics has not authorized anyone to provide you
with information that is different from what is contained in this prospectus.
You should not assume that the information contained in this prospectus is
accurate as of any date other than the date set forth on the front cover of this
prospectus.

                                       61

                      ISONICS CORPORATION AND SUBSIDIARIES
                         INDEX TO FINANCIAL STATEMENTS



                                                                PAGE
                                                              --------
                                                           
Report of Independent Certified Public Accountants..........     F-2

Consolidated Financial Statements for the Years Ended April
  30, 1998 and 1999

  Consolidated Balance Sheets...............................     F-3

  Consolidated Statements of Operations.....................     F-4

  Consolidated Statement of Stockholders' Equity............     F-5

  Consolidated Statements of Cash Flows.....................     F-6

  Notes to Consolidated Financial Statements................     F-7

Condensed Consolidated Financial Statements for the Nine
  Months Ended January 31, 1999 and 2000

  Condensed Consolidated Balance Sheets.....................    F-21

  Condensed Consolidated Statements of Operations...........    F-23

  Condensed Consolidated Statements of Cash Flows...........    F-24

  Notes to Condensed Consolidated Financial Statements......    F-25


                                      F-1

               REPORT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

Board of Directors
Isonics Corporation and Subsidiaries

    We have audited the accompanying consolidated balance sheets of Isonics
Corporation and Subsidiaries as of April 30, 1999 and 1998, and the related
consolidated statements of operations, stockholders' equity, and cash flows for
the years then ended. These financial statements are the responsibility of the
Company's management. Our responsibility is to express an opinion on these
financial statements based on our audits.

    We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

    In our opinion, the financial statements referred to above present fairly,
in all material respects, the consolidated financial position of Isonics
Corporation and Subsidiaries as of April 30, 1999 and 1998, and the consolidated
results of its operations and its cash flows for the years then ended, in
conformity with generally accepted accounting principles.

Grant Thornton LLP

San Jose, California
July 23, 1999, except for Note 13 as to which the date is July 29, 1999

                                      F-2

                      ISONICS CORPORATION AND SUBSIDIARIES

                          CONSOLIDATED BALANCE SHEETS
                      (IN THOUSANDS, EXCEPT SHARE AMOUNTS)



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
                                     ASSETS
CURRENT ASSETS:
  Cash and cash equivalents.................................  $ 1,044    $   452
  Accounts receivable (net of allowances of $130 and $82,
    respectively)...........................................    1,629        932
  Inventories...............................................      456        651
  Prepaid expenses..........................................       45        160
  Deferred income taxes.....................................      112         --
                                                              -------    -------
      Total current assets..................................    3,286      2,195

PROPERTY AND EQUIPMENT, net.................................    1,626      1,018
GOODWILL, net...............................................      236      3,388
NOTES RECEIVABLE FROM SHAREHOLDERS..........................      170        130
OTHER ASSETS................................................       22         75
DEFERRED INCOME TAXES.......................................      315         --
                                                              -------    -------

TOTAL.......................................................  $ 5,655    $ 6,806
                                                              =======    =======

                      LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
  Current portion of long-term debt and line of credit......  $    80    $ 1,136
  Notes payable to related parties..........................       --        922
  Accounts payable..........................................      657      1,368
  Accrued liabilities.......................................      738      1,086
                                                              -------    -------

      Total current liabilities.............................    1,475      4,512

LONG-TERM DEBT..............................................      312         --
DEFERRED INCOME TAXES.......................................      427         --
COMMITMENTS.................................................       --         --

STOCKHOLDERS' EQUITY:
  Common stock--no par value; 20,000,000 shares authorized;
    issued and outstanding: 1998--5,714,250;
    1999--6,607,760.........................................    5,289      6,795
  Notes receivable from shareholders........................     (337)      (469)
  Accumulated deficit.......................................   (1,511)    (4,032)
                                                              -------    -------

      Total stockholders' equity............................    3,441      2,294
                                                              -------    -------

TOTAL.......................................................  $ 5,655    $ 6,806
                                                              =======    =======


                See Notes to Consolidated Financial Statements.

                                      F-3

                      ISONICS CORPORATION AND SUBSIDIARIES

                     CONSOLIDATED STATEMENTS OF OPERATIONS
                    (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)



                                                                  YEAR ENDED
                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Net revenues................................................   $6,783    $16,998
Cost of revenues............................................    4,662     13,375
                                                               ------    -------

    Gross margin............................................    2,121      3,623

Operating expenses:
  Selling, general and administrative.......................    1,342      3,643
  Research and development..................................      811      1,155
  Restructuring and office closure..........................       --        691
                                                               ------    -------

    Total operating expenses................................    2,153      5,489
                                                               ------    -------

Operating loss..............................................      (32)    (1,866)

Other income (expense)
  Interest income...........................................       74         36
  Interest expense..........................................     (219)      (575)
  Foreign currency gain.....................................       --         55
                                                               ------    -------

    Total other expense, net................................     (145)      (484)
                                                               ------    -------

Loss before extraordinary item and taxes....................     (177)    (2,350)

Income tax expense (benefit)................................     (314)       171
                                                               ------    -------

Income (loss) before extraordinary item.....................      137     (2,521)

Extraordinary item--loss on extinguishment of debt..........     (252)        --
                                                               ------    -------

NET LOSS....................................................   $ (115)   $(2,521)
                                                               ======    =======

NET INCOME (LOSS) PER SHARE--BASIC
  Net income (loss) per share before extraordinary item.....   $ 0.03    $ (0.41)
  Extraordinary item........................................   $(0.05)   $    --
  Net loss per share........................................   $(0.02)   $ (0.41)
  Shares used in computing per share information............    5,039      6,210

NET INCOME (LOSS) PER SHARE--DILUTED
  Net income (loss) per share before extraordinary item.....   $ 0.02    $ (0.41)
  Extraordinary item........................................   $(0.04)   $    --
  Net loss per share........................................   $(0.02)   $ (0.41)
  Shares used in computing per share information............    6,469      6,210


                See Notes to Consolidated Financial Statements.

                                      F-4

                      ISONICS CORPORATION AND SUBSIDIARIES

                 CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY
                      (IN THOUSANDS, EXCEPT SHARE AMOUNTS)



                                                                    NOTES
                                              COMMON STOCK        RECEIVABLE
                                          --------------------       FROM       (ACCUMULATED
                                           SHARES      AMOUNT    SHAREHOLDERS     DEFICIT)      TOTAL
                                          ---------   --------   ------------   ------------   --------
                                                                                
BALANCES, May 1, 1997...................  4,550,268    $1,129       $ (343)       $ (1,396)    $   (610)
  Issuance of common stock (net of
    issuance costs of $1,327)...........    810,000     3,452           --              --        3,452
  Interest on notes receivable from
    stockholders........................         --        --          (22)             --          (22)
  Repayment of interest from
    stockholders........................         --        --           28              --           28
  Issuance of common stock in connection
    with Interpro acquisition...........    353,982       708           --              --          708
  Net loss..............................         --        --           --            (115)        (115)
                                          ---------    ------       ------        --------     --------
BALANCES, April 30, 1998................  5,714,250     5,289         (337)         (1,511)       3,441
  Issuance of common stock in connection
    with Chemotrade acquisition.........    357,730       894           --              --          894
  Issuance of common stock in lieu of
    salaries............................    118,182       130           --              --          130
  Conversion of debt into common
    stock...............................    127,209       191           --              --          191
  Exercise of stock options and
    warrants............................    290,389       147         (130)             --           17
  Fair value of warrants issued with
    debt................................         --       144           --              --          144
  Interest on notes receivable from
    stockholders........................         --        --          (24)             --          (24)
  Repayment of interest from
    stockholders........................         --        --           22              --           22
  Net loss..............................         --        --           --          (2,521)      (2,521)
                                          ---------    ------       ------        --------     --------
BALANCES, April 30, 1999................  6,607,760    $6,795       $ (469)       $ (4,032)    $  2,294
                                          =========    ======       ======        ========     ========


                See Notes to Consolidated Financial Statements.

                                      F-5

                      ISONICS CORPORATION AND SUBSIDIARIES

                     CONSOLIDATED STATEMENTS OF CASH FLOWS
                                 (IN THOUSANDS)



                                                                  YEAR ENDED
                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net loss..................................................  $  (115)   $(2,521)
  Adjustments to reconcile net loss to net cash provided by
    (used in) operating activities:
    Depreciation and amortization...........................      200        520
    Interest on notes receivable from shareholders..........      (22)       (24)
    Fair value of warrants issued with debt.................       --        144
    Interest recognized upon conversion of debt to equity...       --         64
    Deferred income taxes...................................     (315)        --
    Loss on disposal of property and equipment..............       --        504
    Issuance of common stock in lieu of salaries............       --        130
    Extraordinary item--loss on extinguishment of debt......      252         --
    Changes in operating assets and liabilities:
      Accounts and notes receivable.........................   (1,232)     1,748
      Inventories...........................................    1,083        (89)
      Prepaid expenses......................................        5         98
      Other assets..........................................        5        (30)
      Accounts payable......................................     (283)      (112)
      Accrued liabilities and other.........................     (117)       (75)
                                                              -------    -------
        Net cash provided by (used in) operating
          activities........................................     (539)       357
CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchases of property and equipment.......................      (72)      (159)
  Cash acquired in purchase of Interpro.....................        6         --
  Purchase of Chemotrade, net of cash acquired..............       --       (546)
                                                              -------    -------
        Net cash used in investing activities...............      (66)      (705)
CASH FLOWS FROM FINANCING ACTIVITIES:
  Net borrowings from line of credit........................       --         16
  Proceeds from issuance of debt............................       --        701
  Repayment of notes receivable from shareholders...........       28         22
  Payments of debt..........................................   (1,852)    (1,000)
  Proceeds from issuance of common stock....................    3,452         17
  Payment of debt issuance costs............................       (7)        --
                                                              -------    -------
        Net cash provided by (used in) financing
          activities........................................    1,621       (244)
                                                              -------    -------
        NET INCREASE (DECREASE) IN CASH AND EQUIVALENTS.....    1,016       (592)
Cash and cash equivalents at beginning of period............       28      1,044
                                                              -------    -------
Cash and cash equivalents at end of period..................  $ 1,044    $   452
                                                              =======    =======


                See Notes to Consolidated Financial Statements.

                                      F-6

                      ISONICS CORPORATION AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

NOTE 1--ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

ORGANIZATION

    Isonics Corporation, (the "Company") develops and markets products worldwide
based on enriched stable isotopes for applications in the energy, medical
research, diagnostic, pharmaceutical and semiconductor industries. Through one
of the Company's subsidiaries, it also provides contract research and
development services.

PRINCIPLES OF CONSOLIDATION

    The consolidated financial statements include the accounts of the Company
and its wholly-owned subsidiaries, International Process Research Corporation
("Interpro"), acquired April 30, 1998, and Chemotrade GmbH ("Chemotrade"),
acquired June 1, 1998. The consolidated balance sheet at April 30, 1998 includes
the assets and liabilities of Isonics Corporation and Interpro. The consolidated
statement of operations for the fiscal year ended April 30, 1998, includes the
results of Isonics Corporation and does not include the operations of Interpro
as the acquisition occurred on the last day of fiscal 1998. The consolidated
balance sheet at April 30, 1999, includes the assets and liabilities of Isonics
Corporation, Interpro and Chemotrade. The consolidated statement of operations
for the fiscal year ended April 30, 1999, includes the results of Isonics and
Interpro for the year then ended and the results of Chemotrade for the eleven
months then ended. All significant intercompany accounts have been eliminated in
consolidation. A pro forma income statement for the year ended April 30, 1999,
has not been presented as the pro forma results of operations for the year would
not have been materially different from the results reported.

CASH EQUIVALENTS

    Cash equivalents include investments purchased with a maturity of less than
ninety days. Cash balances held in foreign bank accounts were $405,000 at April
30, 1999.

CONCENTRATION OF CREDIT RISK

    Financial instruments that potentially subject the Company to concentrations
of credit risk consist primarily of cash equivalents and trade accounts
receivable. Cash equivalents are maintained with high quality institutions and
are regularly monitored by management. The Company extends credit to its
customers, most of whom are large, established companies. Credit risk is
mitigated by performing ongoing credit evaluations of its customers' financial
condition and generally does not require collateral.

INVENTORIES

    Inventories are stated at the lower of cost (first-in, first-out) or market.

PROPERTY AND EQUIPMENT

    Property and equipment are stated at cost. Depreciation is computed using
the straight-line method over five to seven years. Leasehold improvements are
amortized over the shorter of their estimated useful lives or the lease term.

                                      F-7

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 1--ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
GOODWILL

    Goodwill resulted from the acquisitions of Isoserve, Inc. and Chemotrade,
and is being amortized on a straight-line basis over six years and twenty years,
respectively. The Company evaluates the realizability of goodwill to determine
potential impairment by comparing the undiscounted future cash flows of the
related assets. The Company modifies or adjusts goodwill if an impairment is
indicated. Based upon its most recent evaluation, the Company believes that no
impairment of goodwill exists as of April 30, 1999.

INCOME TAXES

    The Company accounts for income taxes using an asset and liability approach
for financial accounting and reporting purposes. A valuation allowance is
provided when deferred tax assets are not expected to be realized.

REVENUE RECOGNITION

    Revenue from product sales is recognized upon shipment. Product returns and
warranty costs have not been material in any period. Revenue from research
contracts is recognized ratably as services are performed and costs are
incurred.

USE OF ESTIMATES IN THE FINANCIAL STATEMENTS

    In preparing financial statements in conformity with generally accepted
accounting principles, management is required to make estimates and assumptions
that affect the reported amounts of assets and liabilities and the disclosure of
contingent assets and liabilities at the date of the financial statements, as
well as revenues and expenses during the reporting period. Actual results could
differ from those estimates.

FAIR VALUES OF FINANCIAL INSTRUMENTS

    The fair value of cash and equivalents, trade receivables and trade payables
approximates carrying value due to the short maturity of such instruments. The
fair value of debt with third-party financial institutions is not determinable
due to the default status of the debt. The fair value of debt with related
parties and promissory notes is not determinable due to the terms of the debt
and no comparable market for such debt.

TRANSLATION OF FOREIGN CURRENCIES

    The Company conducts substantially all of its transactions in U.S. dollars,
except for transactions by its foreign subsidiary. The financial statements of
the Company's foreign subsidiary are denominated in the country's local currency
and remeasured for purposes of consolidation, with the U.S. dollar as the
functional currency. Gains and losses from remeasurement and transaction gains
and losses are included in the statement of operations.

                                      F-8

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 1--ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
ACCOUNTING FOR STOCK-BASED COMPENSATION

    The Company accounts for stock-based awards to employees using the intrinsic
value method in accordance with Accounting Principles Board Opinion No. 25,
ACCOUNTING FOR STOCK ISSUED TO EMPLOYEES. The Company provides additional pro
forma disclosures as required under Statement of Financial Accounting Standards
("SFAS") No. 123, ACCOUNTING FOR STOCK-BASED COMPENSATION.

SEGMENT REPORTING

    The Company has adopted SFAS No. 131, DISCLOSURES ABOUT SEGMENTS OF AN
ENTERPRISE AND RELATED INFORMATION, effective May 1, 1998. SFAS No. 131
establishes new rules for presenting reportable business segments. The adoption
had no effect on the Company's net loss or stockholders' equity.

NET INCOME (LOSS) PER SHARE

    Basic earnings per share is computed using the weighted average number of
common shares outstanding during the period. Diluted earnings per share is
computed using the weighted average number of common and dilutive securities
outstanding during the period. Dilutive securities consist of options and
warrants. Approximately 3,439,000 options and warrants were excluded from the
loss per share calculation in 1999 as the inclusion would be antidilutive.

    The following table reconciles the denominator used in the per share
computation (in thousands):



                                                                  YEAR ENDED
                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Basic shares outstanding....................................   5,039      6,210
Stock options and warrants..................................   1,430         --
                                                               -----      -----
    Diluted shares outstanding..............................   6,469      6,210
                                                               =====      =====


NOTE 2--FINANCIAL STATEMENT COMPONENTS

    Inventories consist of the following (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Finished goods..............................................    $250       $420
Raw Materials...............................................     206        231
                                                                ----       ----
                                                                $456       $651
                                                                ====       ====


                                      F-9

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 2--FINANCIAL STATEMENT COMPONENTS (CONTINUED)
    Property and equipment consists of the following (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Office furniture and equipment..............................   $  118     $  159
Production equipment........................................    1,549      1,094
Leasehold Improvements......................................        4         19
                                                               ------     ------
                                                                1,671      1,272
Accumulated depreciation and amortization...................      (45)      (254)
                                                               ------     ------
                                                               $1,626     $1,018
                                                               ======     ======


    Goodwill related to acquisitions consists of the following (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Isoserve, net of accumulated amortization of $236 and
  $315......................................................   $  236     $  157
Chemotrade, net of accumulated amortization of $0 and
  $155......................................................       --      3,231
                                                               ------     ------
                                                               $  236     $3,388
                                                               ======     ======


    Accrued liabilities consist of the following (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Compensation................................................    $419      $  391
Accrued interest............................................      12          68
Customer advances and deposits..............................      76          97
Other.......................................................     231         530
                                                                ----      ------
                                                                $738      $1,086
                                                                ====      ======


                                      F-10

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 2--FINANCIAL STATEMENT COMPONENTS (CONTINUED)
    Supplemental disclosure of non-cash investing and financing activities (in
thousands):



                                                                  APRIL 30,
                                                             -------------------
                                                               1998       1999
                                                             --------   --------
                                                                  
Stock issued for note receivable...........................   $   --    $   130
                                                              ======    =======
Conversion of trade payables into debt.....................   $   --    $    95
                                                              ======    =======
Forgiveness of note receivable from shareholder............   $   33    $    --
                                                              ======    =======
Purchase of subsidiary
  Cash paid, net of cash acquired..........................   $   --    $   546
  Stock issued to seller...................................      708        894
  Debt issued to seller....................................       --      1,750
  Liabilities assumed......................................    1,464      1,598
  Goodwill.................................................       --     (3,385)
                                                              ------    -------
  Assets acquired..........................................   $2,172    $ 1,403
                                                              ======    =======


    Supplemental disclosures of cash flow information (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Cash paid during the period for:
  Interest..................................................    $177       $475
  Income taxes..............................................       1        227


                                      F-11

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 3--INCOME TAXES

    Deferred tax assets (liabilities) are comprised of the following (in
thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Deferred tax assets
  Accruals and expenses deductible in future periods........   $ 297     $ 1,269
  Net operating loss carryforwards..........................     211         435
                                                               -----     -------
      Total deferred tax assets.............................     508       1,704
  Valuation allowance.......................................     (81)     (1,178)
                                                               -----     -------
                                                                 427         526
Deferred tax liabilities
  Amortization and depreciation.............................    (427)       (526)
                                                               -----     -------
                                                               $  --     $    --
                                                               =====     =======


    Income tax expense (benefit) consists of the following (in thousands):



                                                                     APRIL 30,
                                                              -----------------------
                                                                1998           1999
                                                              --------       --------
                                                                       
Current
  Federal...................................................   $  --           $ --
  State.....................................................       1             --
  Foreign...................................................      --            171
                                                               -----           ----
                                                                   1            171

Deferred
  Federal...................................................    (230)            --
  State.....................................................     (85)            --
                                                               -----           ----
                                                                (315)            --
                                                               -----           ----
                                                               $(314)          $171
                                                               =====           ====


    The primary differences between the statutory federal tax rate and the
effective rate in 1999 are the taxable earnings of the Company's foreign
subsidiary, the non-deductibility of certain expenses associated with warrants
and commons shares issued with debt and upon debt conversion and the valuation
allowance provided against deferred tax assets. In 1998, the primary differences
resulted from the non-deductibility of certain expenses associated with the
extinguishment of debt and the valuation allowance provided against the deferred
tax assets. The change in the valuation allowance for deferred tax assets for
the years ended April 30, 1998 and 1999 was $81,000 and $1,097,000,
respectively. The Company provided a valuation allowance for its deferred tax
asset to the extent it believes realization of such asset is uncertain.

    The Company has $1,086,000 of net operating loss carryforwards for federal
purposes and associated state net operating loss carryforwards, which expire at
various dates through 2019. Current federal and state tax law includes certain
provisions limiting the annual use of net operating loss

                                      F-12

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 3--INCOME TAXES (CONTINUED)
carryforwards in the event of certain defined changes in stock ownership. The
annual use of the Company's net operating loss carryforwards could be limited
according to these provisions.

NOTE 4--DEBT AND LINE OF CREDIT

    Debt and line of credit consist of the following (in thousands):



                                                                   APRIL 30,
                                                              -------------------
                                                                1998       1999
                                                              --------   --------
                                                                   
Bank term loan--guaranteed by the SBA, repaid in 1999.......    $ 40      $   --
Bank term loan, repaid in 1999..............................     306          --
Revolving line of credit....................................      --         514
Notes payable to related parties............................      --         922
10% Subordinated promissory note............................      --          92
Unsecured promissory notes..................................      --         494
Other.......................................................      46          36
                                                                ----      ------
                                                                 392       2,058
Less current maturities.....................................      80       2,058
                                                                ----      ------
      Long-term debt........................................    $312      $   --
                                                                ====      ======


    The revolving line of credit with Coast Business Credit ("Coast"), the
Company's primary lender, is secured by substantially all of the assets of the
Company. Interest is at prime (7.75% at April 30, 1999) plus 4%. The loan
consists of the following:

    - $500,000 equipment term loan, payable over forty eight equal monthly
      installments of principal and interest;

    - $250,000 term loan, with interest only payments due monthly and principal
      due October 31, 1998;

    - $500,000 revolving line of credit, borrowings are limited to 35% of
      eligible inventory;

    - $1,250,000 revolving line of credit, borrowings are limited to 80% of
      eligible accounts receivable; and

    - $500,000 equipment acquisition term loan, borrowings are limited to 80% of
      invoice cost of equipment, payable over thirty-six monthly installments of
      principal and interest. The availability of the loan is conditioned upon
      the Company achieving and maintaining minimum debt service coverage
      ratios.

    In April 1999, Coast sent notification that Isonics was in default of the
terms of the loan agreements. As a result, Coast placed substantial restrictions
on the availability of funds and established revised repayment terms. Because of
this default, the entire outstanding balance has been classified as current.
Borrowings under the loan are presently limited to eligible receivables and
inventory amounts.

    Notes payable to related parties consist of an $812,000 (DM1,500,000) note
payable to the sellers of Chemotrade and other unsecured notes to officers and
directors amounting to $110,000. The Chemotrade note is secured by the shares of
Chemotrade, bears interest at 10% and was due in June

                                      F-13

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 4--DEBT AND LINE OF CREDIT (CONTINUED)
1999. The Company paid $550,000 towards the Chemotrade note principal in July
1999 and extended the due date of the balance to July 31, 1999. In consideration
for the extension, the Company will grant one $3 warrant for each $5 of deferred
payment. The unsecured notes to officers and directors bear interest at 5% per
month and are payable upon demand.

    Unsecured promissory notes consist of two notes bearing interest at prime
plus 4% for $200,000 each to a vendor and a $94,500 note to a different vendor.
The $200,000 notes were due in April 1999. The Company issued 75,000 warrants to
the vendor in connection with the $200,000 notes. The fair value of these
warrants, $144,000, was recorded as additional interest expense for the period.
The $94,500 note represents the conversion of certain trade payables into a
non-interest bearing note due in seven equal monthly installments beginning in
June 1999.

NOTE 5--COMMITMENTS

    The Company rents office, production facilities and equipment under
operating leases expiring through July 2003. Rent expense for operating leases
was approximately $39,000 and $202,000 for the years ended April 30, 1998 and
1999, respectively. Future minimum annual operating lease commitments are as
follows (in thousands):


                                                                  
       2000........................................................  $197,000
       2001........................................................   161,000
       2002........................................................    44,000
       2003........................................................    18,000
       2004........................................................     9,000
                                                                     --------
                                                                     $429,000
                                                                     ========


    The Company is required to make royalty payments to Isoserve, Inc. for
depleted zinc metal sold through fiscal 2000. The maximum royalty payments under
the agreement are $1,000,000. The Company paid royalties of $192,000 and
$110,000 for the years ended April 30, 1998 and 1999, respectively, and has paid
$633,000 of royalties since inception through April 30, 1999. At April 30, 1999,
the company had accrued royalties payable under this agreement amounting to
$88,000.

NOTE 6--STOCKHOLDERS' EQUITY

    On August 11, 1997, the Board of Directors approved a 3 for 1 stock split of
its common shares. All per share amounts, number of shares, stock options and
warrant data have been restated to reflect the stock split.

COMMON STOCK

    On September 22, 1997, the Company completed an initial public offering of
810,000 units, each unit consisting of one share of common stock and one
redeemable common stock purchase warrant. Each warrant entitles the holder to
purchase one share of common stock at $5.80 per share, commencing September 22,
1998. The Company may redeem the warrants commencing March 21, 1999 at a price
of $.10 per warrant if the closing price of the common stock is at lease $14.50
per share for at lease 20 consecutive trading days.

                                      F-14

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 6--STOCKHOLDERS' EQUITY (CONTINUED)
    In connection with the offering, the Company granted the underwriter
warrants to purchase up to 160,000 shares of common stock at a weighted average
exercise price of $7.77. The warrants are exercisable for a four year period
commencing September 22, 1998.

    The Company has reserved shares of common stock for issuance as follows:



                                                              APRIL 30,
                                                                1999
                                                              ---------
                                                           
Exercise of stock options...................................  1,208,356
Exercise of warrants........................................  2,442,475
Employee stock purchase plan................................    200,000
                                                              ---------
                                                              3,850,831
                                                              =========


STOCK OPTION PLAN

1996 STOCK OPTION PLAN

    The Company's 1996 Stock Option Plan authorized the grant of 1,727,832
incentive and nonqualified stock options to key employees, directors or
consultants of the Company. Incentive stock options are granted at a price not
less than fair market value, and nonqualified stock options are granted at a
price not less than 85% of the fair market value, as determined by the Board of
Directors. Options generally become exercisable upon issuance under the 1996
Stock Option Plan and are subject to redemption rights typically over three
years and generally expire ten years after the date of grant. In September 1997,
the Board of Directors terminated the Company's 1996 Stock Option Plan.

EXECUTIVE AND INCENTIVE STOCK OPTION PLANS

    In November 1996, the Board of Directors adopted the Executive and Incentive
Stock Options Plans authorizing the granting of up to 570,000 and 150,000
incentive and nonqualified stock options to key employees, directors or
consultants of the Company, respectively. Incentive stock options are granted at
a price not less than fair market value, and nonqualified stock options are
granted at a price not less than 85% of the fair market value. Options are
exercisable when vested, typically over five years and expire ten years after
the date of grant.

    The exercise price of the options generally approximates the fair market
value per share of the Company's stock on the date of grant. Accordingly, no
compensation cost has been recognized for grants made from the plans. Had
compensation cost for the plans been determined based on the fair value of the
options at the grant dates consistent with SFAS No. 123, ACCOUNTING FOR
STOCK-BASED

                                      F-15

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 6--STOCKHOLDERS' EQUITY (CONTINUED)
COMPENSATION, the Company's net loss and net loss per share for the years ended
April 30, 1998 and 1999 would have been changed to the pro forma amounts
indicated below.



                                                         1998         1999
                                                       ---------   -----------
                                                             
Net loss
  As reported........................................  $(115,000)  $(2,521,000)
  Pro forma..........................................   (379,000)   (3,174,000)

Loss per share (diluted)
  As reported........................................  $   (0.02)  $     (0.41)
  Pro forma..........................................      (0.06)        (0.51)


    The fair value of each option grant is estimated on the date of grant using
the Black-Scholes options-pricing model with the following weighted average
assumptions; no expected dividends, volatility of 150%; risk-free interest rate
of 6.0%; and expected lives of 5 years. A summary of the status of the Company's
stock option plans as of April 30, 1998 and 1999, and changes during the years
ending on these dates is presented below.



                                                                           WEIGHTED
                                                                           AVERAGE
                                                              NUMBER OF    EXERCISE
                                                                SHARES      PRICE
                                                              ----------   --------
                                                                     
Outstanding, May 1, 1997....................................     684,809    $0.72
  Granted...................................................     382,500    $3.82
  Exercised.................................................          --       --
  Canceled..................................................     (12,500)   $2.60
                                                              ----------

Outstanding, April 30, 1998.................................   1,054,809    $1.84
  Granted...................................................     480,721    $1.71
  Exercised.................................................    (195,830)   $0.66
  Canceled..................................................    (343,123)   $3.35
                                                              ----------

Outstanding, April 30, 1999.................................     996,577    $1.49
                                                              ==========


    The weighted average fair value of options granted during the years ended
April 30, 1998 and 1999 was $3.25 and $1.56, respectively.

    The following information applies to options outstanding at April 30, 1999:



RANGE OF EXERCISE PRICES                      $0.58     $1.00-$1.44   $1.62-$2.38   $2.56-$3.50
- ------------------------                     --------   -----------   -----------   -----------
                                                                        
Options outstanding........................   336,927     255,721       223,929       180,000
Weighted average exercise price............  $   0.58    $   1.25      $   1.95      $   2.98
Weighted average remaining contractual life
  (years)..................................         7          10             9             9

Options exercisable........................   336,927     144,721        59,072       105,000
Weighted average exercise price............  $   0.58    $   1.36      $   1.89      $   3.28


                                      F-16

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 6--STOCKHOLDERS' EQUITY (CONTINUED)

    In fiscal 1997, two executive officers of the Company exercised stock
options to each acquire 259,175 shares of common stock at an exercise price of
$0.64 per share. In fiscal 1999, two other executive officers exercised stock
options to acquire 57,603 and 138,227 shares of common stock at exercise prices
of $0.87 and $0.58, respectively. In each case, the Company loaned the executive
officer the aggregate amount representing the exercise price of the option, and
the officer executed a promissory note reflecting the loan. Each executive
officer pledged the purchased shares as collateral for the loan pursuant to a
pledge agreement. Each loan bears interest at an annual rate equal to the
minimum applicable federal rate, and interest is payable annually; principal and
accrued but unpaid interest is due five years from the date of the note. Until
each note has been paid in full and upon any sale of such option shares by the
respective executive, a portion of the sales proceeds will be used to pay
amounts owed under the note. In addition, during fiscal 1998, the Company loaned
to each of the two executive officers related to the fiscal 1997 option
exercises, pursuant to a five-year note with interest at the minimum applicable
federal rate, the amount equal to the federal and state tax liability incurred
by him as a result of exercising such option, and to pay compensation to such
officer equal to the amount of interest payable under these loans and the amount
of taxes payable as a result of such compensation. At April 30, 1998, principal
and interest due on the loans to acquire the common stock totaled $330,000 and
$7,000, respectively. At April 30, 1999, principal and interest due on the loans
to acquire the common stock totaled $460,000 and $9,000, respectively. At April
30, 1998, principal and interest on the loans to pay the federal and state tax
liability incurred as a result of exercising such option totaled $123,000 and
$3,000, respectively. At April 30, 1999, principal and interest on the loans to
pay the federal and state tax liability incurred as a result of exercising such
option totaled $126,000 and $4,000, respectively. During fiscal 1998, the
executives received compensation of $38,000 to repay interest payable to the
Company on the common stock and tax notes.

EMPLOYEE STOCK PURCHASE PLAN

    The Company had in effect an employee stock purchase plan under which
200,000 shares of the Company's common stock were reserved for issuance to all
permanent employees who have met minimum employment criteria. Employees who do
not own 5% or more of the outstanding shares are eligible to participate through
payroll deductions. At the end of each offering period, shares are purchased by
the participants at 85% of the lower of the fair market value at the beginning
or the end of the offering period. No stock has been issued under the plan as of
April 30, 1999.

NOTE 7--EXTRAORDINARY ITEM

    The terms of the Company's non-convertible promissory notes stated that in
the event of an initial public offering of the Company's stock, all principal
and interest would be due within five days of the closing of such initial public
offering. Accordingly, the Company repaid the notes and interest in fiscal 1998.
At the time of repayment, unamortized debt issuance costs and discounts totaling
$252,000 were charged to earnings as an extraordinary item.

NOTE 8--EMPLOYEE BENEFIT PLAN

    The Company has established a profit sharing plan under section 401(k) of
the Internal Revenue Code. The plan is a defined contribution plan, covering
substantially all employees of the Company. Company contributions to the plan
aggregated approximately $3,000 and $30,000 for 1998 and 1999.

                                      F-17

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 9--CONCENTRATIONS

    Four separate customers accounted for 10% or more of net revenues in fiscal
1998: 47%, 18%, 12% and 11%. Two separate customers accounted for 10% or more of
net revenues in fiscal 1999: 23% and 13%.

    Sales by geographic region are as follows (in thousands):



                                                                1998       1999
                                                              --------   --------
                                                                   
United States...............................................   $6,354     $8,072
Europe......................................................      331      8,348
Other.......................................................       98        578


NOTE 10--BUSINESS SEGMENTS AND FOREIGN OPERATIONS

    The Company has two operating segments: Stable Isotope Production and
Contract Research and Development Services. The Company's reportable segments
are strategic business units that offer different products and services. They
are managed based on the fundamental differences in their operations.

    Information by segment is set forth below (in thousands):



                                                               1998       1999
                                                             --------   --------
                                                                  
Net revenues
  Stable Isotope Production................................   $6,783    $14,384
  Contract Research and Development Services...............       --      2,614

Operating income (loss)
  Stable Isotope Production................................   $  (32)   $(1,035)
  Contract Research and Development Services...............       --       (831)

Identifiable assets
  Stable Isotope Production................................   $4,189    $ 5,713
  Contract Research and Development Services...............    1,466      1,093

Depreciation and amortization
  Stable Isotope Production................................   $  200    $   263
  Contract Research and Development Services...............       --        257

Net capital expenditures
  Stable Isotope Production................................   $   72    $    88
  Contract Research and Development Services...............       --         71


                                      F-18

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 10--BUSINESS SEGMENTS AND FOREIGN OPERATIONS (CONTINUED)
    A summary of the Company's operations by geographic area is presented below
(in thousands):



                                                              1998       1999
                                                            --------   --------
                                                                 
Net revenues
  United States...........................................   $6,783    $  6,817
  Germany.................................................       --      10,181

Operating income (loss)
  United States...........................................   $  (32)   $ (2,322)
  Germany.................................................       --         456

Identifiable assets
  United States...........................................   $5,655    $  5,507
  Germany.................................................       --       1,299


NOTE 11--RESTRUCTURING

    In October 1998, the Company recorded a charge to operations amounting to
$708,000 relating to a planned restructuring of the Company's operations. This
charge consisted primarily of lease termination costs, employee severance pay
and the write down of fixed assets. As of April 30, 1999, the company had
implemented nearly all of the changes in the operations and expected to incur
approximately $65,000 of additional costs to be expensed in the year ending
April 30, 2000. The Company reduced the accrual for restructuring costs by
$17,000 in the quarter ended April 30, 1999, to reflect the actual costs
incurred. A liability amounting to $61,000 remains as a recorded liability at
April 30, 1999 relating to the lease termination costs.

NOTE 12--ACQUISITIONS

    On April 30, 1998, the Company acquired all of the outstanding common stock
of Interpro. The purchase price was paid in 353,982 shares of the Company's
common stock with a fair market value of $708,000. Transaction costs were
$70,000 and no goodwill was recognized upon completing the transaction. The
results of operations for Interpro are included from May 1, 1998, as the
acquisition occurred on the last day of the fiscal year ended April 30, 1998.

    On July 21, 1998, the Company acquired all of the outstanding shares of
Chemotrade GmbH and subsidiary (collectively "Chemotrade"), which was owned by
two shareholders. Chemotrade is engaged in the distribution, development and
manufacturing of stable and radioisotopes. The purchase price has been accounted
for effective June 1, 1998, the date control was transferred. The purchase price
was denominated in German Deutsche Marks, and all amounts reported below are
translated at the historical conversion rate unless otherwise noted. The
purchase price consideration on June 1, 1998 consisted of $2.576 million paid at
closing and $1.07 million to be paid through June 2001. Transaction costs were
$125,000. Imputed interest from the effective date of the acquisition, June 1,
1998, totaled $28,000.

    The consideration paid upon closing consisted of cash of $758,000, 357,730
restricted shares of common stock with a fair market value of $894,000, and two
notes. The first note of $924,000 (DM1,663,000) bore interest at 2% per month
and was paid in August 1998, and the second note of $812,000 (DM1,500,000) bears
interest at 10%, due on June 1, 1999.

                                      F-19

                      ISONICS CORPORATION AND SUBSIDIARIES

             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

NOTE 12--ACQUISITIONS (CONTINUED)
    The purchase agreement provides for the selling shareholders to receive
additional consideration in the event certain levels of pretax earnings are
achieved in the periods ending through April 30, 2001. The agreement also
contains a provision to reduce the consideration given if the pretax earnings
are not achieved for each of the years ended April 30, 2000 and 2001. The
maximum additional consideration that can be earned is $271,000 (DM500,000). Any
additional consideration will be recorded as additional goodwill.

    Pro forma results of operations as if the acquisitions of Interpro and
Chemotrade had occurred at the beginning of fiscal 1998, combining the audited
results of operations of Isonics for the year ended April 30, 1998 with the
results of operations of Interpro and Chemotrade for the years ended April 29,
1998 and May 31, 1998, respectively, are as follows (in thousands):


                                                           
Net revenues................................................  $16,990
Gross margin................................................    3,998
Net loss....................................................     (174)
Net loss per share..........................................     (.03)
Number of shares used in computing per share information....    5,751


NOTE 13--SUBSEQUENT EVENTS

    On July 29, 1999, the Company completed a private placement financing to
accredited investors and certain creditors valued in total at $2.7 million. The
Company issued 1,830,000 units, each consisting of one share of Series A
Convertible Preferred Stock and one warrant. The Company received $2,250,000
cash proceeds and converted $425,000 of long-term debt in connection with the
private placement. Each share of the Series A Convertible Preferred Stock is
convertible into one share of the Company's common stock at a conversion price
of $1.50. The liquidation preference for the Series A Convertible Preferred
Stock is $1.50. Each warrant allows the investor to purchase one share of the
Company's common stock for $3.75 through July 29, 2002.

    In addition to converting $425,000 of existing debt into equity as part of
the private placement, the Company:

    - issued 500,000 warrants to purchase shares of the Company's common stock
      to an investment banker as a commission on this placement. The warrants
      are exercisable at $3.75 per share through July 29, 2002.

    - issued 46,667 units in satisfaction of all currents and future obligations
      under the Isoserve royalty agreement.

    - extended the payment due date for the remaining balance on the Chemotrade
      acquisition note to July 2000 and extended the payment due date for
      certain unsecured promissory notes to January, 2000.

    Management believes that the proceeds and the revised debt structure
resulting from the private placement and additional strategies developed by
management will be sufficient to fund operations for the next twelve months.

                                      F-20

                      ISONICS CORPORATION AND SUBSIDIARIES

                     CONDENSED CONSOLIDATED BALANCE SHEETS
                                 (IN THOUSANDS)

                                     ASSETS



                                                              JANUARY 31, 2000
                                                              ----------------
                                                                (UNAUDITED)
                                                           
CURRENT ASSETS:
  Cash and cash equivalents.................................       $ 4,576
  Accounts receivable (Net of allowance of $82).............         1,915
  Inventories...............................................           233
  Prepaid expenses and other current assets.................            72
                                                                   -------

    Total current assets....................................       $ 6,796
                                                                   -------

LONG-TERM ASSETS:
  Property and equipment, net...............................           784
  Goodwill, net.............................................         3,104
  Notes receivable from shareholders........................             0
  Other assets..............................................            32
                                                                   -------
    Total long-term assets..................................       $ 3,920
                                                                   -------
TOTAL ASSETS................................................       $10,716
                                                                   =======


           See Notes to Condensed Consolidated Financial Statements.

                                      F-21

                      ISONICS CORPORATION AND SUBSIDIARIES

                     CONDENSED CONSOLIDATED BALANCE SHEETS
                      (IN THOUSANDS, EXCEPT SHARE AMOUNTS)

                      LIABILITIES AND SHAREHOLDERS' EQUITY



                                                              JANUARY 31, 2000
                                                              ----------------
                                                                (UNAUDITED)
                                                           
CURRENT LIABILITIES:
  Notes payable and line of credit..........................       $    24
  Notes payable to related parties..........................             0
  Accounts payable..........................................         1,364
  Accrued liabilities.......................................         1,341
                                                                   -------
    Total current liabilities...............................       $ 2,729
                                                                   -------

SHAREHOLDERS' EQUITY:
  Class A Preferred Stock--no par value. 10,000,000 shares
    authorized; 1,830,000 shares outstanding................         2,745
  Common stock--no par value. 20,000,000 shares authorized;
    6,663,017 shares issued and outstanding on January 31,
    2000....................................................         6,765
  Notes receivable from shareholders........................          (210)
  Accumulated deficit.......................................        (1,313)
                                                                   -------
    Total shareholders' equity..............................       $ 7,987
                                                                   -------

TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY..................       $10,716
                                                                   =======


           See Notes to Condensed Consolidated Financial Statements.

                                      F-22

                      ISONICS CORPORATION AND SUBSIDIARIES

                CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
                                  (UNAUDITED)



                                                                NINE MONTHS ENDED
                                                                   JANUARY 31,
                                                              ----------------------
                                                                1999          2000
                                                              --------      --------
                                                                      
Net revenues................................................  $14,309       $11,115
Cost of revenues............................................   11,575         8,792
                                                              -------       -------
    Gross margin............................................    2,734         2,323

Operating expenses:
  Selling, general and administrative.......................    2,444         3,117
  Research and development..................................      962           919
  Restructuring and office closure..........................      708            60
                                                              -------       -------
    Total operating expenses................................    4,114         4,096
                                                              -------       -------

Operating (loss)............................................   (1,380)       (1,773)
                                                              -------       -------

Other income (expense):
  Foreign exchange..........................................       35           (64)
  Interest income...........................................       21            55
  Gain on sale of product line..............................       --         5,296
  Interest expense..........................................     (236)         (325)
                                                              -------       -------
    Total other income (expense), net.......................     (180)        4,962
                                                              -------       -------
Income (loss) before income taxes...........................   (1,560)        3,189
Income tax expense..........................................      197           471
                                                              -------       -------
NET INCOME (LOSS)...........................................  $(1,757)      $ 2,718
                                                              =======       =======

NET INCOME (LOSS) PER SHARE--BASIC
Net income (loss) per share.................................  $ (0.29)      $  0.41
Shares used in computing per share information..............    6,120         6,610

NET INCOME (LOSS) PER SHARE--DILUTED
Net income (loss) per share.................................  $ (0.29)      $  0.31
Shares used in computing per share information..............    6,120         8,906


           See Notes to Condensed Consolidated Financial Statements.

                                      F-23

                      ISONICS CORPORATION AND SUBSIDIARIES

                CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                 (IN THOUSANDS)
                                  (UNAUDITED)



                                                               NINE MONTHS ENDED
                                                                  JANUARY 31,
                                                              -------------------
                                                                1999       2000
                                                              --------   --------
                                                                   
Net cash (used in) provided by operating activities.........  $   146    $(2,904)
CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchase of Chemotrade, net of cash acquired..............     (546)        --
  Sale of depleted zinc business............................       --      6,730
  Purchases of property and equipment.......................     (120)       (20)
                                                              -------    -------
    Cash provided by (used in) investing activities.........  $  (666)   $ 6,710
                                                              -------    -------
CASH FLOWS FROM FINANCING ACTIVITIES:
  Net change in line of credit..............................      931       (513)
  Proceeds from issuance of notes payable...................      500         75
  Repayments of notes payable...............................   (1,714)    (1,494)
  Proceeds from issuance of common stock....................       17         --
  Proceeds from issuance of Class A Preferred Stock.........       --      2,250
  Payments of debt issuance costs...........................      (30)        --
                                                              -------    -------
    Cash provided by (used in) financing activities.........  $  (296)   $   318
                                                              -------    -------
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS:.......     (816)     4,124
  Cash and cash equivalents at beginning of period..........    1,044        452
                                                              -------    -------
  Cash and cash equivalents at end of period................  $   228    $ 4,576
                                                              =======    =======
Supplemental disclosure of cash flow information: Cash paid
  during the period for:
    Interest................................................  $   149    $   252
                                                              =======    =======
    Income taxes............................................  $   242    $    53
                                                              =======    =======
Supplemental disclosure of noncash investing and financing
  activities:
    Accounts payable converted into notes payable...........  $    --    $   243
    Liabilities converted into Class A Preferred Stock......       --        495
    Equipment acquired under capital lease..................       14         --
    Issuance of warrants in conjunction with notes
      payable...............................................       --        245
    Retirement of Common Stock by shareholders to pay off
      subscriptions.........................................       --        275
                                                              =======    =======
    Purchase of Chemotrade:
      Cash paid, net of cash acquired.......................  $   546
      Stock issued to sellers...............................      894
      Notes payable issued to sellers.......................    1,750
      Liabilities assumed...................................    1,598
                                                              -------
        Assets acquired (including goodwill of $3,385)......  $ 4,788
                                                                         =======


           See Notes to Condensed Consolidated Financial Statements.

                                      F-24

                      ISONICS CORPORATION AND SUBSIDIARIES

              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

BASIS OF PRESENTATION

    The accompanying condensed consolidated financial statements of Isonics
Corporation and Subsidiaries (the "Company" or "Isonics") as of January 31,
2000, and for the nine months ended January 31, 2000, and 1999, have been
prepared on the same basis as the annual audited financial statements. In the
opinion of management, such unaudited information includes all adjustments
(consisting only of normal recurring accruals) necessary for a fair presentation
of this interim information. Operating results and cash flows for interim
periods are not necessarily indicative of results for the entire year.

NET INCOME (LOSS) PER SHARE

    A total of approximately 1,513,000 and 3,400,000 outstanding stock options
and warrants have been excluded from the diluted earnings per share calculation
for the nine month ended January 31, 2000 and 1999, respectively, as the
inclusion would be anti-dilutive. An additional 4,000,000 warrants were excluded
from the calculation for the nine month ended January 31, 2000 as the issuance
of the underlying shares is contingent upon the delivery of silicon-28 per the
terms of the Eagle-Picher Transaction.

RECONCILIATION OF EARNINGS PER SHARE CALCULATIONS



                                                             NINE MONTHS ENDED
                                                                JANUARY 31,
                                                            -------------------
                                                              2000       1999
                        Numerator                           --------   --------
                                                                 
Net income (loss).........................................    2,718      (1,757)
Preferred stock dividends.................................       --          --
                                                             ------    --------
Net income (loss) used in computing basic income (loss)
  per common share........................................   $2,718    $ (1,757)
Preferred stock dividends.................................       --          --
                                                             ------    --------
Net income (loss) used in computing diluted income (loss)
  per common share........................................    2,718      (1,757)
                                                             ======    ========

                       Denominator
Weighted average common shares outstanding during the
  period..................................................    6,610       6,120
Dilutive effect of conversion of preferred stock..........    1,220          --
Dilutive effect of options and warrants using the treasury
  stock method............................................    1,076          --
                                                             ------    --------
Shares used in computing diluted income (loss) per common
  share...................................................    8,906       6,120
                                                             ======    ========


                                      F-25

                      ISONICS CORPORATION AND SUBSIDIARIES

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

INVENTORIES

    Inventories consist of (in thousands):



                                                              JANUARY 31, 2000
                                                              ----------------
                                                           
Finished goods..............................................        $138
Work in progress............................................          95
Raw materials...............................................          --
                                                                    ----
  Total inventories.........................................        $233
                                                                    ====


NOTES PAYABLE--RELATED PARTIES

    Two notes were issued to each of the sellers of Chemotrade GmbH and
subsidiary as consideration for a portion of the purchase price. The first note
was repaid in August 1998. A partial payment of approximately $550 thousand was
paid in June 1999, on the second note. The remaining balance of approximately
$343 thousand including interest, was refinanced and was originally payable July
31, 2000. The new interest rate was 12% per annum. In addition, approximately
70,000 warrants (five-year, $3.00 strike price) were issued in June 1999, in
conjunction with the refinancing. The fair value of these warrants was
determined to be $157 thousand, using the Black-Scholes option pricing model,
and this value has been amortized as additional interest expense. This note, and
all accrued interest, was paid in December 1999, with proceeds made available
from the Eagle-Picher Transaction, described in more detail below in the
paragraph entitled "SALE OF DEPLETED ZINC BUSINESS."

SIGNIFICANT CUSTOMERS

    At January 31, 2000, one customer accounted for 33% of total accounts
receivable. The same customer accounted for approximately 18% of net revenues
during the nine months ended January 31, 2000. The same customer accounted for
approximately 17% of net revenues during the nine months ended January 31, 1999.

                                      F-26

                      ISONICS CORPORATION AND SUBSIDIARIES

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

SEGMENT INFORMATION (IN THOUSANDS)



                                                             NINE MONTHS ENDED
                                                                JANUARY 31,
                                                           ----------------------
                                                             2000          1999
                                                           --------      --------
                                                                   
Segment revenues:
  Isotope products.......................................  $10,098       $11,991
  Contract research and development services and other...    1,017         2,318
                                                           -------       -------
      Total..............................................  $11,115       $14,309




                                                             NINE MONTHS ENDED
                                                                JANUARY 31,
                                                           ----------------------
                                                             2000          1999
                                                           --------      --------
                                                                   
Segment operating (loss) income:
  Isotope products.......................................  $(1,387)      $(1,217)
  Contract research and development services and other...     (386)         (163)
                                                           -------       -------
      Total..............................................  $(1,773)      $(1,380)




                                                              JANUARY 31, 2000
                                                              ----------------
                                                           
Identifiable Assets:
  Isotope products..........................................       $ 9,750
  Contract research and development services and other......           966
                                                                   -------
      Total.................................................       $10,716


    A summary of operations by geographic area is as follows:



                                                             NINE MONTHS ENDED
                                                                JANUARY 31,
                                                           ----------------------
                                                             2000          1999
                                                           --------      --------
                                                                   
Net revenues:
  United States..........................................  $ 3,904       $ 6,964
  Germany................................................    7,211         7,345
                                                           -------       -------
      Total..............................................  $11,115       $14,309




                                                             NINE MONTHS ENDED
                                                                JANUARY 31,
                                                           ----------------------
                                                             2000          1999
                                                           --------      --------
                                                                   
Operating (loss) income:
  United States..........................................  $(1,982)      $(1,107)
  Germany................................................      209          (273)
                                                           -------       -------
      Total..............................................  $(1,773)      $(1,380)


                                      F-27

                      ISONICS CORPORATION AND SUBSIDIARIES

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



                                                              JANUARY 31, 2000
                                                              ----------------
                                                           
Identifiable Assets:
  United States.............................................       $ 8,798
  Germany...................................................         1,918
                                                                   -------
      Total.................................................       $10,716


SALE OF DEPLETED ZINC BUSINESS

    On December 1, 1999, we sold our depleted zinc business to Eagle-Picher
Technologies, LLC. ("Eagle-Picher") for approximately $8.2 million, of which
$6.7 million was paid on December 1, 1999. Additionally, we signed a long-term
isotope supply agreement with Eagle-Picher, and Eagle-Picher will supply us in
2000 with 200 kilograms of silicon-28 to be used in research and development
activities. We also gave Eagle-Picher a warrant to obtain 4,000,000 shares of
our common stock. The warrants are contingent upon the delivery of silicon-28 by
Eagle-Picher. As silicon-28 is delivered we will record the value of the silicon
and the warrants proportionately (20,000 warrants per kilogram), at a value of
$25.00 per gram. This is the price we most recently paid for silicon-28 from
another supplier.

    The balance of $1.5 million is payable in three annual installments of $500
thousand. These installments are contingent upon the performance of an
unaffiliated supplier of depleted zinc whose contract with us was assigned to
Eagle-Picher. We will recognize the contingent gain on a straight-line basis
over the thirty-six month period, approximately $41,500 per month, as the
supplier performs under the contract. Two months, or approximately $83,000, have
been recognized in the quarter ended January 31, 2000.

    We do not anticipate significant revenues from sales of silicon-28 based
products in the fiscal year ended April 30, 2000. We are collaborating with
academia and industry to evaluate the benefits of isotopically pure silicon-28.
We believe that if evaluations demonstrate the commercial feasibility of one or
more products, demand could emerge in certain segments of the semiconductor
market. We can offer no assurance, however, that these evaluations will
demonstrate the commercial feasibility of any products, that we will be able to
commercialize any such products, or that a market will emerge for any such
products.

                                      F-28