Exhibit 10.75

                            LEASE EXTENSION AGREEMENT


This agreement is dated June 26, 2000 for reference purposes and is an
additional modification to the current Lease Agreement dated November 30, 1990
between Charles A. Grant and Mark Greenberg (LESSOR) and Urnotech Calypte
Biomedical Corporation (LESSEE) for the property known as 1440 Fourth Street,
Berkeley, California.

Except as indicated below all other terms and conditions of the Lease
Agreement remain unchanged.

     1.       LEASE EXTENSION AND RENT PAYMENT. The lease is hereby extended
              four months through December 31, 2000. The lease payment for this
              extension will remain $27,000.00 per month.

     2.       HOLDING OVER. If LESSEE remains in possession of the premises per
              Paragraph 26 (Holding Over), then the agreed monthly rent is
              $29,000.



LESSOR                                           LESSEE

                                                 Calypte Biomedical Corporation

/s/ Charles A. Grant                             by    /s/ Nancy E. Katz
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                                                       Nancy E. Katz

Title:  Partner (Gen)                            Title:   CEO, President, CFO
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Date:   6/28/00                                  Date:  6/26/00
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