EXHIBIT 99.1 Contact: Gwenetta B. Como Director, Investor Relations and Corporate Communications Carolyn M. Felzer Senior Director of Finance 858/455-9800 info@corvas.com CORVAS REPORTS THIRD QUARTER RESULTS San Diego, CA, October 23, 2000 -- Corvas International, Inc. (Nasdaq:CVAS) today reported financial results for the third quarter ended September 30, 2000. Operating revenues of $856,000 and operating expenses of $4.3 million resulted in a net loss of $3.1 million, or $.15 per share. In the third quarter of 1999, operating revenues of $1.5 million and operating expenses of $7.0 million resulted in a net loss of $5.4 million, or $.34 per share. The decrease in research and development expenses in the third quarter of 2000 compared with the third quarter of 1999 was primarily due to timing differences in contract manufacturing activities in the respective periods. The decrease in general and administrative expenses was primarily the result of one-time charges of $2.0 million incurred in the third quarter of 1999 related to a settlement agreement entered into with the Vascular Genomics Inc. For the nine months ended September 30, 2000, operating revenues of $5.3 million and operating expenses of $13.7 million resulted in a net loss of $7.6 million, or $.37 per share. Results for the first nine months of 1999 included operating revenues of $4.8 million, operating expenses of $15.5 million and a net loss of $10.1 million, or $.65 per share. Cash, cash equivalents and short-term investments at September 30, 2000 were $30.9 million. Corvas International, Inc. is a biopharmaceutical company engaged in the discovery, development and commercialization of novel therapeutics that address large markets, including cardiovascular disease, stroke and cancer. This press release, as well as the Company's SEC filings and web site at http://www.corvas.com, contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Actual results could vary materially from those described as a result of a number of factors, including those set forth in Corvas' Annual Report on Form 10-K and subsequent SEC filings. In addition, there is the risk that current clinical trials, or any future trials undertaken, 1 whether by us or our collaborators, will not be successful, and that the Company may never successfully develop or commercialize any therapeutics to address cardiovascular disease, stroke or cancer. The Company undertakes no obligation to revise or update these forward-looking statements to reflect events or circumstances after the date of this press release. STATEMENT OF OPERATIONS DATA: THREE MONTHS ENDED SEPT. 30, NINE MONTHS ENDED SEPT. 30, 2000 1999 2000 1999 ---- ---- ---- ---- (unaudited) (unaudited) (in thousands, except per share data) Revenues: Revenue from collaborative agreements $ 750 $ 1,394 $ 2,513 $ 4,694 License fees and milestones 0 0 2,500 0 Royalties 50 86 117 122 Research grants 56 0 159 0 ------------ ------------ ------------ ------------ Total revenues 856 1,480 5,289 4,816 ------------ ------------ ------------ ------------ Costs and expenses: Research and development 3,370 4,119 10,891 10,901 General and administrative 947 2,929 2,841 4,564 ------------ ------------ ------------ ------------ Total costs and expenses 4,317 7,048 13,732 15,465 ------------ ------------ ------------ ------------ Loss from operations (3,461) (5,568) (8,443) (10,649) Interest income 519 190 1,403 585 Interest expense (190) (43) (569) (43) ------------ ------------ ------------ ------------ Net loss and other comprehensive loss $ (3,132) $ (5,421) $ (7,609) $ (10,107) ========== ========== ========== ========== Basic and diluted net loss per share $ (0.15) $ (0.34) $ (0.37) $ (0.65) ========== ========== ========== ========== Shares used in calculation of basic and diluted net loss per share 21,221 15,833 20,657 15,371 ============ ============ ============ ============ BALANCE SHEET DATA: SEPTEMBER 30, DECEMBER 31, 2000 1999 ---- ---- (unaudited) (in thousands) Cash, cash equivalents and short-term investments $ 30,860 $ 21,511 Working capital 28,804 20,278 Total assets 33,204 23,889 Long term debt 10,770 10,215 Accumulated deficit (98,479) (90,870) Total stockholders' equity 19,086 11,275 ### 2