PRUDENTIAL MUNICIPAL
                                  SERIES FUND
                         -----------------------------

                  (MASSACHUSETTS SERIES, NORTH CAROLINA SERIES
                                AND OHIO SERIES)

                       Supplement Dated November 3, 2000
                       Prospectus Dated November 3, 2000

  The Board of Trustees of Prudential Municipal Series Fund (the Fund) has
recently approved a proposal to exchange the assets and liabilities of
Massachusetts Series, North Carolina Series and Ohio Series (each individually,
a Series, and collectively, the Series) of the Fund for shares of Prudential
National Municipals Funds, Inc. (National Municipals Fund). Class A, B and C
shares of the Series would be exchanged at net asset value for Class A shares of
equivalent value of National Municipals Fund. Class Z shares of Massachusetts
Series would be exchanged at net asset value for Class Z shares of equivalent
value of National Municipals Fund.

  The transfer has been approved by the Trustees of the Fund and by the Board of
Directors of National Municipals Fund and is subject to approval by the
shareholders of the Series. The shareholders' meeting with respect to each
Series is scheduled to occur on December 7, 2000. A proxy statement/prospectus
relating to the transactions is being mailed to each Series' shareholders with
this supplement.

  The Fund no longer accepts orders to purchase or exchange into its shares of
any class of any Series, except for (1) certain Retirement and Employee Plans
(excluding IRA accounts) that are currently shareholders, and successor or
related programs and plans, (2) investors who have executed a Letter of Intent
prior to August 24, 2000, (3) shareholders who have elected to reinvest
dividends and/or distributions, (4) purchases made by former shareholders in
connection with the 90-day repurchase privilege and (5) current shareholders
participating in automatic investment plans. The current exchange privilege of
obtaining shares of other

MF2000C8

Prudential Mutual Funds and the current redemption rights will remain in effect
until the transaction is consummated.

  The investment objective of National Municipals Fund is to seek a high level
of current income that is exempt from federal income taxes.