Aetna Inc.
[Aetna Logo]                                            151 Farmington Avenue
[Aetna Letterhead]                                      Hartford, CT  06156-8975


                                                        GINA M. BUTCH
                                                        Paralegal
                                                        AFS Law, TS31
December 14, 2000                                       (860) 273-0701
                                                        Fax:  (860) 273-3004


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC  20549

Re:  AETNA LIFE INSURANCE AND ANNUITY COMPANY
     REGISTRATION STATEMENT ON FORM S-2
     PROSPECTUS TITLE:  AETNA MULTI-RATE ANNUITY
     RULE 424(b)(3) FILING
     FILE NO.: 333-48774

Ladies and Gentlemen:

Submitted for filing pursuant to Rule 424(c) and Rule 424(b)(3) of the
Securities Act of 1933 (the "33 Act") is a Supplement dated December 14, 2000
to the Prospectus dated May 1, 2000 for Aetna Life Insurance and Annuity
Company ("ALIAC"). The Prospectus dated May 1, 2000 is incorporated into this
filing by reference to Post Effective Amendment No. 4 to Registration Statement
on Form S-2 (File No. 333-49593), as filed with the Securities and Exchange
Commission on April 13, 2000 and as amended by supplement filed with the
Commission under Rules 424(c) and 424(b)(3) on August 21, 2000 (the
"Prospectus"). This supplement replaces the supplement dated August 21, 2000
and discloses that ALIAC has become part of ING Groep N.V. and that Aetna
Investment Services, LLC has become the principal underwriter for the
securities sold under the Prospectus. It, therefore, contains substantive
information that will vary from that contained in the Prospectus filed in Post
Effective Amendment No. 4 to Registration Statement on Form S-2 (File
No. 333-49593), as filed with the Commission on April 13, 2000 and declared
effective on May 1, 2000.

If you have any questions regarding this submission, please contact the
undersigned at (860) 273-0701.

Sincerely,

/s/  Gina M. Butch

Gina M. Butch