SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING


                                                                 
                                                                               Commission File Number 0-28443

(Check One):      [ X ] Form 10-K     [   ] Form 33-K     [   ] Form 20-F    [   ] Form 10-Q [   ] Form N-SAR

         For Period Ended: December 31, 2000
                           --------------------------------------------

[   ] Transition Report on Form 10-K                                   [   ] Transition Report on Form 10-Q
[   ] Transition Report on Form 20-F                                   [   ] Transition Report on Form N-SAR
[   ] Transition Report on Form 11-K



         For the Transition Period Ended:   ___________________________________

         Nothing in this form shall be construed to imply that the Commission
has verified any information contained herein.

         If the notification relates to a portion of the filing checked above,
identify the item(s) to which the notification relates: ________________________

                                     PART I

                             REGISTRANT INFORMATION

Full name of registrant Cytomedix Inc.
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Former name if applicable
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Address of principal executive office (STREET AND NUMBER)   Three Parkway North
                                                            -------------------

City, state and zip code   Deerfield, Illinois  60015
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                                     PART II

                             RULE 12b-25(b) AND (c)

         If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed. (Check appropriate box.)

[   ]    (a)      The reasons described in reasonable detail in Part III of this
form could not be eliminated without unreasonable effort or expense;

[X] (b) The subject annual report, semi-annual report, transition report on Form
10-K, Form 20-F, 11-K, or Form N-SAR, or portion thereof will be filed on or
before the fifteenth calendar day following the prescribed due date; or the
subject quarterly report or transition report on Form 10-Q, or portion thereof
will be filed on or before the fifth calendar day following the prescribed due
date; and

[   ]    (c)      The accountant's statement or other exhibit required by
Rule 12b-25(c) has been attached if applicable.



                                    PART III

                                    NARRATIVE

         State below in reasonable detail the reasons why Form 10-K, 11-K, 20-F,
10-Q, N-SAR or the transition report portion thereof, could not be filed within
the prescribed time period. (Attach extra sheets if needed)

         The registrant cannot file its Annual Report on Form 10-KSB within the
prescribed time period because the registrant will require additional time to
complete and describe some current events, specifically, two separate equity and
debt financings, the effect of which the Registrant believes will result in
material changes to the Registrant's disclosures on the Form 10-KSB and its
financial condition.

                                     PART IV

                                OTHER INFORMATION

         (1)      Name and telephone number of person to contact in regard to
this notification

James Cour                 (847)    405-7810
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(Name)                     (Area Code) (Telephone Number)

         (2) Have all other periodic reports required under Section 13 or 15(d)
of the Securities Exchange Act of 1934 or Section 30 of the Investment Company
Act of 1940 during the preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed? If answer is no,
identify report(s).

                                           [ X ] Yes                 [   ] No

         (3) Is it anticipated that any significant change in results of
operations from the corresponding period for the last fiscal year will be
reflected by the earnings statements to be included in the subject report or
portion thereof?

                                           [   ] Yes                 [ X ] No

         If so: attach an explanation of the anticipated change, both
narratively and quantitatively, and, if appropriate, state the reasons why a
reasonable estimate of the results cannot be made.

                                Cytomedix, Inc.
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                  (Name of Registrant as Specified in Charter)

Has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Dated:   April 2, 2001                   By:  /s/ James Cour
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                                         Name:    James Cour
                                         Title:   President

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