Filed pursuant to Rule 424(b)(3)
                                                      Registration No. 333-37696

                              PROSPECTUS SUPPLEMENT
                              Dated April 12, 2001
                              To the prospectus of

                               ISONICS CORPORATION
                             Dated January 26, 2001


         This supplements the prospectus dated January 26, 2001, issued by
Isonics Corporation in connection with its offer to exchange outstanding
Class A Common Stock Purchase Warrants for Class B Common Stock Purchase
Warrants on a warrant-for-warrant basis. The exchange offer is described in
more detail in the prospectus dated January 26, 2001, which prospectus this
supplement provides additional information. This supplement should be read in
conjunction with the prospectus dated January 26, 2001.

         INTERNATIONAL PROCESS RESEARCH CORPORATION. Effective February 1,
2001, we sold our wholly-owned subsidiary, International Process Research
Corporation, to a limited liability company, Interpro Zinc LLC, in a
management buy-out which included participation by our president, James E.
Alexander, and our senior vice president, Boris Rubizhevsky. Mr. Alexander
and Mr. Rubizhevsky each acquired a 25% interest in Interpro Zinc LLC.
Because of their participation in the management buy-out, the transaction was
considered and approved by the disinterested members of our Board of
Directors. International Process Research Corporation is discussed in more
detail in the prospectus under "MANAGEMENT'S DISCUSSION AND ANALYSIS -
REORGANIZATION OF INTERPRO SUBSIDIARY" commencing on page 27, "BUSINESS -
RECENT BUSINESS ACQUISITIONS" commencing at page 39, and "BUSINESS - PRODUCTS
- - ZINC RECOVERY AND RECYCLING BUSINESS OPPORTUNITY" commencing at page 47.

         We did not receive any cash for the purchase price, but Interpro
Zinc assumed approximately $700,000 in liabilities associated with the
operations of International Process Research Corporation (including
cancellation of an employment contract between us and a former officer,
Robert H. Cuttriss who became the manager of Interpro Zinc). Interpro Zinc
agreed to indemnify us against any contingent liabilities related to the
Interpro site in Golden. As a part of the transaction, we transferred patent
rights and other intellectual property related to the recovery of zinc, and
we acquired a 25% interest in Interpro Zinc. As a result of the sale and the
release from the operating expenses of the assets transferred to Interpro
Zinc, we expect that our cash flow will improve by approximately $100,000 per
month.

         EAGLE-PICHER INDUSTRIES, INC. AND EAGLE-PICHER TECHNOLOGIES, LLC.
The prospectus describes our dispute with Eagle-Picher and our efforts to
resolve that dispute through management discussion and mediation. These
efforts were unsuccessful and, on March 26, 2001, we filed for arbitration of
this dispute with the American Arbitration Association in Dallas, Texas. In
our filing, we claimed damages in excess of $10,000,000, including
Eagle-Picher's failure to supply 200 kilograms of silicon-28 required under
the November 30, 1999, asset purchase agreement, a refusal to deliver
silicon-28 under our isotope supply agreement, a failure to pay $500,000 that
was due November 30, 2000, an anticipatory breach of their obligation to pay
an additional $500,000 due in 2001 and 2002, and additional damages.

         As described in the prospectus ("RISK FACTORS - NEED FOR ADDITIONAL
FINANCING" on page 11, "MANAGEMENT'S DISCUSSION AND ANALYSIS - SALE OF
DEPLETED ZINC BUSINESS" on page 26, on December 1, 1999, we sold our depleted
zinc business to Eagle-Picher Technologies, LLC ("Eagle-Picher") for
approximately $8.2 million, of which $6.7 million was paid on December 1,
1999. We had recognized approximately $458,000 of this amount as income when
Eagle-Picher defaulted in its payment obligation and, as a result, we
established a reserve against collectibility of this amount. Additionally as
described in the prospectus, as of December 1, 1999, we signed a long-term
isotope supply agreement with Eagle-Picher, and Eagle-Picher was to have
supplied us by December 31, 2000, with 200 kilograms of silicon-28 to be used
in research and development activities. We gave Eagle-Picher a warrant to
obtain 4,000,000 shares of our common stock, however, these warrants and the
underlying shares, were contingent upon the delivery of silicon-28 by
Eagle-Picher by December 31, 2000. As silicon-28 was to be delivered we
intended to record the value of the silicon and the warrants proportionately
(20,000 warrants per kilogram), at a value of $25.00 per gram. This is the
price we most recently paid for silicon-28 from another



supplier. Eagle-Picher did not deliver 200 kilograms of silicon-28. We know
that Eagle-Picher's silicon-28 production facility in Oklahoma has
encountered certain technical difficulties, which Eagle-Picher refers to as a
FORCE MAJEURE. We believe that Eagle-Picher's technical difficulties do not
meet the definition of FORCE MAJEURE per our agreements, which would entitle
Eagle-Picher to a delay in the delivery requirement.

         Eagle-Picher exercised its warrant, under a net exercise provision
in the warrant agreement, and received 3,130,435 shares of our Common Stock,
in March 2000. Eagle-Picher disputed our calculation and believed we should
have issued to it an additional 155,279 shares of Common Stock. We believed
Eagle-Picher's calculation to have been in error. As Eagle-Picher is claiming
FORCE MAJEURE, it believes it is entitled to retain its ownership to the
3,130,435 shares, as well as the disputed 155,279 shares of our Common Stock.
We continue to dispute Eagle-Picher's calculations, and we also believe
Eagle-Picher may have improperly exercised the Warrant because of its failure
to execute the required subscription agreement. On January 26, 2001, our
Board of Directors authorized us to cancel Eagle-Picher's common stock shares
and return those shares to the "authorized, unissued" category. We cancelled
the shares on February 20, 2001.

         On February 8, 2001, Eagle-Picher informed us that they would be
seeking damages, in excess of $10,000,000, for alleged misrepresentations
regarding the status of the depleted zinc business at the time of the sale,
and this allegation forms the basis for Eagle-Picher's claim in arbitration.
We believe these allegations to be groundless, and we believe we made full
and complete disclosure to Eagle-Picher at the time of the sale.

         As a result of Eagle-Picher's alleged breaches and defaults, we do
not anticipate having the 200 kilograms of silicon-28 meeting the
specifications set forth in the agreement, as promised by Eagle-Picher. We
have other sources of supply for silicon-28 meeting the necessary
specifications, although orders have not been placed. Without silicon-28
meeting our specifications our research and development activities will be
hindered. Additionally, Eagle-Picher's failure to make the payment due on
November 30, 2000, has caused our working capital to be significantly
reduced, and we are seeking other means of financing our operations.

         The arbitration proceeding has only recently commenced, and neither
party has filed any response to the other's claims. Consequently, although we
believe that our claims have merit and we do not believe that Eagle-Picher
will be able to support their claims, we cannot offer any assurance that we
will, in fact, succeed in the prosecution of our claims or our defense
against Eagle-Picher's claims.

         ADVANCES TO OFFICERS. On March 1, 2001, we advanced $50,000 each to
its president and senior vice president. On April 1, 2001, we advanced an
additional $50,000 to each of them. These advances bore interest at 6.6% per
annum, and the officers paid the interest currently. On April 12, 2001, our
disinterested directors agreed to their repayment of these advances by each
of the two officers returning 80,000 shares of common stock to us. This was
completed at a price of $1.25 per share which the independent directors
determined to be a fair price to us in light of recent market activity which
reflected prices in excess of $1.25 per share. The two officers expect to
tender the shares to us before April 20, 2001.

EXCEPT FOR HISTORICAL INFORMATION CONTAINED HEREIN, THIS DOCUMENT CONTAINS
FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF THE PRIVATE SECURITIES
LITIGATION REFORM ACT OF 1995. THESE STATEMENTS INVOLVE KNOWN AND UNKNOWN
RISKS AND UNCERTAINTIES THAT MAY CAUSE THE COMPANY'S ACTUAL RESULTS OR
OUTCOMES TO BE MATERIALLY DIFFERENT FROM THOSE ANTICIPATED AND DISCUSSED
HEREIN. FURTHER, THE COMPANY OPERATES IN INDUSTRIES WHERE SECURITIES VALUES
MAY BE VOLATILE AND MAY BE INFLUENCED BY REGULATORY AND OTHER FACTORS BEYOND
THE COMPANY'S CONTROL. OTHER IMPORTANT FACTORS THAT THE COMPANY BELIEVES
MIGHT CAUSE SUCH DIFFERENCES ARE DISCUSSED IN THE RISK FACTORS DETAILED IN
THE COMPANY'S 10-KSB FOR THE YEAR ENDED APRIL 30, 2000, AND ITS QUARTERLY
REPORT ON FORM 10-QSB FOR THE SIX MONTHS ENDED OCTOBER 31, 2000, BOTH AS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION, WHICH INCLUDE THE
COMPANY'S CASH FLOW DIFFICULTIES, DEPENDENCE ON SIGNIFICANT CUSTOMERS, AND
RAPID DEVELOPMENT OF TECHNOLOGY, AMONG OTHER RISKS. IN ASSESSING
FORWARD-LOOKING STATEMENTS CONTAINED HEREIN, READERS ARE URGED TO CAREFULLY
READ ALL CAUTIONARY STATEMENTS CONTAINED IN THE COMPANY'S FILINGS WITH THE
SECURITIES AND EXCHANGE COMMISSION.


                        PROSPECTUS DATED JANUARY 26, 2001
                               ISONICS CORPORATION
                       810,000 CLASS B REDEEMABLE WARRANTS
                       810,000 CLASS C REDEEMABLE WARRANTS
                   1,620,000 SHARES OF COMMON STOCK UNDERLYING
          CLASS A REDEEMABLE WARRANTS, CLASS B REDEEMABLE WARRANTS, AND
                           CLASS C REDEEMABLE WARRANTS


         Isonics Corporation ("Isonics," the "Company," or "We") hereby
offers holders of outstanding Class A Redeemable Warrants and Class A
Redeemable Warrants that may be issued upon the exercise of certain
outstanding warrants ("Underwriter's Warrants") the opportunity through April
30, 2001, to exchange their Class A Redeemable Warrants ("Class A Warrants")
for Class B Redeemable Warrants ("Class B Warrants"). The exercise price for
the Class B Warrants is $1.50 per share. If you exercise the Class B Warrants
before their expiration date, we will issue to you one share of Common Stock
and one Class C Redeemable Warrant ("Class C Warrants"). The Class B Warrants
will expire on December 31, 2005. The Class C Warrants (which we will issue
to you only if you exercise the Class B Warrants or if you exercise Class A
Warrants on or before April 30, 2001) expire December 31, 2005, and will be
exercisable for one share of Common Stock at a price of $2.50 per share. The
Class C Warrants and (effective May 1, 2001) the Class B Warrants are
redeemable if our Common Stock trades at or above $3.75 per share for any 20
of 30 consecutive trading days provided a registration statement permitting
the exercise of those warrants is then current and effective.

         In addition, Isonics is offering up to a maximum of 1,620,000 shares
of Common Stock to holders of our Class A Warrants, Class B Warrants, and
Class C Warrants who may choose to exercise those warrants in accordance with
their terms before their expiration dates (December 31, 2005 with respect to
the Class B and Class C Warrants, and September 30, 2001, with respect to the
Class A Warrants). In accordance with SEC Rule 429, this prospectus also
constitutes the prospectus under post-effective amendment number 1 to our
Registration Statement on Form SB-2 for the exercise of our Class A Warrants.

         Should you choose to do so, you may also exercise your Class B
Warrants when you submit your Class A Warrants for exchange. You must
exercise your Class A Warrants or (if received upon exchange) your Class B
Warrants before their respective expiration dates or you will lose your right
to exercise those warrants.

         Our Common Stock and Class A Warrants are traded in the
over-the-counter market and quoted on the Nasdaq SmallCap Stock Market under
the symbols "ISON" and "ISONW", respectively. On January 17, 2001, the
reported closing price of our Common Stock was $1.9063 per share and of our
Class A Warrants was $1.0938 per warrant. Our Class B Warrants and Class C
Warrants are eligible for trading under the symbols ISONX and ISONY,
respectively, but no Class C Warrants have been issued, and only 675,000
restricted Class B Warrants have been issued; consequently no trading market
has developed.

         AN INVESTMENT IN OUR CLASS B WARRANTS AND OUR COMMON STOCK (SHOULD
YOU CHOOSE TO EXERCISE ANY OF OUR WARRANTS) INVOLVES A HIGH DEGREE OF RISK.
SEE "RISK FACTORS" BEGINNING ON PAGE 4. In deciding whether to exchange the
warrants offered, you should rely only on the information contained in this
document. We have not authorized anyone to provide you with any information
that is different from this information.

         NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE
SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED THESE SECURITIES OR
DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO
THE CONTRARY IS A CRIMINAL OFFENSE.



         ONLY RESIDENTS OF COLORADO, DELAWARE, GEORGIA, ILLINOIS, NEVADA, AND
NEW YORK, MAY EXCHANGE THEIR CLASS A WARRANTS, OR EXERCISE THEIR CLASS A
WARRANTS, CLASS B WARRANTS, OR CLASS C WARRANTS. WE HAVE NOT QUALIFIED THE
CLASS A WARRANTS, CLASS B WARRANTS, OR CLASS C WARRANTS UNDER THE LAWS OF ANY
OTHER STATE. WHEN YOU EXERCISE THE CLASS A WARRANTS, CLASS B WARRANTS, OR
CLASS C WARRANTS, YOU WILL HAVE TO PROVIDE US INFORMATION AS TO YOUR STATE OF
RESIDENCE. WE MAY SEEK QUALIFICATION FROM TIME-TO-TIME IN OTHER STATES. YOU
MAY CALL ISONICS CORPORATION AT 303-279-7900, TO DETERMINE WHETHER YOUR STATE
OF RESIDENCE HAS BEEN INCLUDED.

                                  -----------

         Isonics has not authorized anyone to give any information or make
any representation about the offering that differs from, or adds to, the
information in this prospectus or in its documents that are publicly filed
with the Securities and Exchange Commission. Therefore, if anyone does give
you different or additional information, you should not rely on it. The
delivery of this prospectus and/or the exchange of warrants to purchase
Common Stock does not mean that there have not been any changes in Isonics'
condition since the date of this prospectus. If you are in a jurisdiction
where it is unlawful to offer to exchange or exercise the securities offered
by this prospectus, or if you are a person to whom it is unlawful to direct
such activities, then the offer presented by this prospectus does not extend
to you. This prospectus speaks only as of its date except where it indicates
that another date applies. Documents that are incorporated by reference in
this prospectus speak only as of their date, except where they specify that
other dates apply. The information in this prospectus is not complete and may
be changed. The holders may not exchange and exercise these securities until
the registration statement filed with the Securities and Exchange Commission
is effective. This prospectus is not an offer to exchange or exercise these
securities and it is not soliciting an offer to exchange or exercise these
securities in any state where the exchange or exercise is not permitted.

                                  -----------



                                    SUMMARY

         This summary presents selected information from this prospectus. You
should carefully read this entire document and the documents to which the
prospectus refers in order to understand this offering. SEE "HOW TO OBTAIN
ADDITIONAL INFORMATION."

ISONICS CORPORATION

         Isonics is an advanced materials and technology company, which
develops and commercializes products based on enriched stable and radioactive
isotopes. The Common Stock of Isonics is traded on the Nasdaq SmallCap Market
under the symbol "ISON." The market for our stock has historically been
characterized generally by low volume, and broad price and volume volatility.
We cannot give any assurance that a stable trading market will develop for
our stock.

         The address of our principal executive offices and our telephone and
facsimile numbers at that address are:

                  Isonics Corporation
                  5906 McIntyre Street
                  Golden, Colorado 80403
                  Telephone No.: (303) 279-7900
                  Facsimile No.: (303) 279-7300

TRADING SYMBOLS


                                                            
         Common Stock.........................................  "ISON"
         Class A Warrants.....................................  "ISONW"
         Class B Warrants.....................................  "ISONX"
         Class C Warrants.....................................  "ISONY"


         The Common Stock and the Class A Warrants are quoted on the Nasdaq
SmallCap Market. No Class C Warrants have been issued and only 675,000
restricted Class B Warrants have been issued; therefore, no market has
developed for either the Class B Warrants or the Class C Warrants.

THE EXCHANGE OFFER

GENERAL.  Isonics hereby offers holders of our outstanding Class A Warrants
the opportunity to exchange their Class A Warrants for an equal number of
Class B Warrants. The Class B Warrants will:

         -    be exercisable for one share of Common Stock and one Class C
              Warrant, for a purchase price of $1.50 per share,

         -    expire December 31, 2005, and

         -    be redeemable if our Common Stock trades at or above $3.75 per
              share for any 20 of 30 consecutive trading days on or after
              May 1, 2001.

         When issued to holders who exercise their Class B Warrants (or to
holders who exercise their Class A Warrants before the Exchange Offer
expires), the Class C Warrants will:



         -    be exercisable for one share of Common Stock at a price of
              $2.50 per share,

         -    expire December 31, 2005, and

         -    be redeemable if our Common Stock trades at or above $3.75 per
              share for any 20 of 30 consecutive trading days.

         Class A Warrants submitted for exchange will be cancelled. The offer
to exchange the outstanding Class A Warrants for Class B Warrants will expire
on April 30, 2001, unless extended. The Class A Warrants expire on September
21, 2001.

         Any person who has exercised a Class A Warrant prior to this
exchange offer will be given a Class C Warrant for no additional
consideration, thus giving the Class A Warrant holder who exercised prior to
this exchange offer the same value as the Class A Warrant holders who accept
this exchange offer before exercise. Isonics will not receive any cash
proceeds from the exchange, however, Isonics will receive proceeds upon
exercise of the Class B Warrants or the Class C Warrants, if any are
exercised.

TERM OF THE EXCHANGE OFFER AND PROCEDURES FOR EXCHANGING WARRANTS. This
exchange offer will remain open until April 30, 2001, or such later date as
the Board of Directors may determine. To submit your Class A Warrants for
exchange, you should complete the Letter of Transmittal accompanying this
prospectus and deliver it to the exchange agent, prior to the expiration of
the exchange offer, all as described in the section entitled "THE EXCHANGE
OFFER." AN INVESTMENT IN OUR CLASS B WARRANTS, OUR CLASS C WARRANTS, AND OUR
COMMON STOCK IS SUBJECT TO A SUBSTANTIAL AMOUNT OF RISK, INCLUDING THE RISK
OF LOSING YOUR ENTIRE INVESTMENT. SEE "RISK FACTORS."

         The method of delivery of Letters of Transmittal and certificates to
the exchange agent will be at the election and risk of each holder of the
Class A Warrants. The Letters of Transmittal and certificates can be sent to
the exchange agent by hand delivery, courier service, or by mail. If you send
the Letters of Transmittal and certificates by mail, we recommended that you
send them by registered mail with return receipt requested; we also recommend
that you allow a sufficient number of days to ensure that your Letter of
Transmittal and certificates are delivered to the exchange agent prior to the
expiration time.

         Isonics will determine all questions concerning the timeliness,
validity, form, and eligibility of submissions. Our determination on these
matters will be binding. We may, in our sole discretion, waive any defect or
irregularity, or permit a defect or irregularity to be corrected within such
time as we may establish; alternatively, we may reject any purported
submission. Letters of Transmittal will not be deemed to have been received
or accepted until all irregularities have been waived or cured within such
time as we may determine in our sole discretion.

NO WITHDRAWAL RIGHTS. Any tender of the Class A Warrants to the exchange
agent will be irrevocable. A holder who has submitted his or her Class A
Warrants for exchange may not withdraw them. Isonics has the right, in its
sole discretion, to extend the expiration date of the exchange offer or offer
withdrawal rights on a case-by-case basis in the future.

CONSEQUENCES OF FAILURE TO EXCHANGE. There are no consequences if you fail to
exchange your Class A Warrants before the expiration date of the exchange
offer. You will continue to own your Class A Warrants, which will be subject
to the same terms and conditions as prior to the exchange offer. The exchange
offer expires on April 30, 2001, unless extended, and after that date you
will no longer have a right to exchange your Class A Warrants for Class B
Warrants. The Class A Warrants will expire on September 21, 2001.

NO PROCEEDS FROM EXCHANGE OFFER. Isonics will not receive any proceeds from
any person in connection with the exchange offer. Isonics will only receive
proceeds from persons who choose, in their discretion, to exercise the



Class A Warrants, the Class B Warrants, and/or the Class C Warrants. Any
proceeds that Isonics may receive from the exercise of warrants will be added
to our working capital and used for corporate purposes.


THE OFFERING

         We are offering a total of 810,000 shares of Common Stock to persons
who exercise either the outstanding Class A Warrants or the Class B Warrants,
which may be issued in exchange for the outstanding Class A Warrants to the
extent any holder decides to accept the Exchange Offer. (This does not
include up to 80,000 Class A warrants, which may be issued to holders of
warrants issued in September 1997 to the underwriter of our initial public
offering. If the holder exercises these warrants, referred to as the
"Underwriters' Warrants," a total of 890,000 shares of Common Stock may be
issued upon full exercise of the outstanding Class A Warrants or the Class B
Warrants.) The total number of 810,000 may consist of shares issued to
persons exercising Class A Warrants, Class B Warrants, or a combination of
Class A Warrants and Class B Warrants. As of the date of this Prospectus,
675,000 restricted Class B Warrants have been issued.

         We are also offering a total of 810,000 shares of Common Stock to
persons who receive Class C Warrants and exercise their Class C Warrants. We
will issue Class C Warrants to any person who exercises a Class A Warrant on
or before April 30, 2001, or who exercises a Class B Warrant received in
exchange for a Class A Warrant, on or before December 31, 2005. As of the
date of this Prospectus, no Class C Warrants have been issued.


USE OF PROCEEDS

         We will receive from $0.00 (if no Class A Warrants are exercised) to
a maximum of $4,698,000.00 (if all of the Class A Warrants are exercised.) We
will receive from $0.00 to a maximum of $2,227,500.00 (if all of the Class A
Warrants are exchanged for Class B Warrants, and all of the Class B Warrants
are all exercised.) The total number of Class A Warrants that could be
exercised (excluding any Class A Warrants which may be issued upon the
exercise of the Underwriters' Warrants, which we believe to be unlikely) is
810,000. The total number of Class B Warrants that could be exercised is
1,485,000. The Class B Warrant total includes 810,000 warrants received
through the exchange offer, and 675,000 warrants issued on December 13, 2000.
The latter scenario is more likely as it minimizes the cash investment by the
holders of our Class A Warrants. We expect to use any proceeds, from the
exercise of Class A Warrants and/or Class B Warrants, for research and
development and working capital.

         If any Class C Warrants are issued and exercised (of which there can
be no assurance), we will receive from $0.00 to a maximum of $3,712,500.00.
The total number of Class C Warrants that could be exercised is 1,485,000,
all of which would be initially obtained through the exercise of Class B
Warrants. Both the Class B Warrants and the Class C Warrants will be publicly
tradable upon acceptance of this registration statement and other
registration statements we intend to file in the near future. We expect to
use any proceeds, from the exercise of Class C Warrants, for research and
development and working capital.


RISK FACTORS

         THE PURCHASE OF ISONICS' COMMON STOCK INVOLVES A HIGH DEGREE OF
RISK. YOU SHOULD EXERCISE YOUR CLASS A WARRANTS, CLASS B WARRANTS, AND/OR
CLASS C WARRANTS ONLY IF YOU CAN AFFORD A COMPLETE LOSS OF YOUR INVESTMENT.
SEE "RISK FACTORS." We have not authorized anyone to give you information or
to make any representation other than those contained in this prospectus.



A NOTE ABOUT FORWARD-LOOKING STATEMENTS

         In our effort to make the information in this prospectus more
meaningful, this prospectus contains both historical and forward-looking
statements. All statements other than statements of historical fact are
forward-looking statements within the meanings of Section 27A of the
Securities Act of 1933, and Section 21E of the Securities Exchange Act of
1934. Forward-looking statements in this prospectus are not based on
historical facts, but rather reflect the current expectations of our
management concerning future results and events.

         The forward-looking statements generally can be identified by the
use of terms such as "believe," "expect," "anticipate," "intend," "plan,"
"foresee," "likely," "will" or other similar words or phrases. Similarly,
statements that describe our objectives, plans, or goals are, or may be,
forward-looking statements.

         Forward-looking statements involve known and unknown risks,
uncertainties and other factors that may cause the actual results,
performance or achievements of Isonics to be different from any future
results, performance and achievements expressed or implied by these
statements. You should review carefully all information, including the
financial statements and the notes to the financial statements included in
this prospectus. In addition to the factors discussed under "Risk Factors,"
the following important factors could affect future results, causing the
results to differ materially from those expressed in the forward-looking
statements in this prospectus:

         -    our working capital shortage, which has been aggravated by
              certain collection issues related to accounts and notes
              receivable, which are significantly past due, and our need for
              additional financing;

         -    demand for, and acceptance of, our materials;

         -    changes in development, distribution, and supply relationships;

         -    the impact of competitive products and technologies and no
              assurance as to the validity of our intellectual property rights;

         -    the risk of operations in Russia, the Republic of Uzbekistan,
              and the Republic of Georgia;

         -    dependence on future product development;

         -    the possibility of future customer concentration;

         -    our dependence on key personnel;

         -    the volatility of our stock price and the potential adverse
              impact on our market which may be caused by future sales of
              restricted securities;

         -    the possibility of environmental violations relating to our
              business activities and products;

         -    the fact that at the present time Isonics does not have
              sufficient authorized capital to permit the exercise of all
              outstanding options and warrants, and conversion of all
              outstanding preferred stock; and

         -    the impact of new technologies.

         These factors are not necessarily all of the important factors that
could cause actual results to differ



materially from those expressed in the forward-looking statements in this
prospectus. Other unknown or unpredictable factors also could have material
adverse effects on the future results of Isonics. The forward-looking
statements in this prospectus are made only as of the date of this prospectus
and Isonics does not have any obligation to publicly update any
forward-looking statements to reflect subsequent events or circumstances.
Isonics cannot assure you that projected results will be achieved.


                                 RISK FACTORS

         An investment in Isonics Corporation Common Stock is one of high
risk. You should carefully consider the risks described below before deciding
whether to invest in Isonics Corporation. If any of the contingencies
discussed in the following paragraphs or other materially adverse events
actually materialize, the business, financial condition and results of
operations could be materially and adversely affected. In such a case, the
trading price of our Common Stock could decline, and you could lose all or
part of your investment.


HISTORY OF LOSSES; ENGAGING IN NEW LINES OF BUSINESS

         We have not operated profitably to date since inception. Through
October 31, 1999 (the end of our fiscal quarter immediately preceding the
Eagle-Picher transaction,) we recognized accumulated losses of more than
$4,500,000, notwithstanding receiving substantial revenues from the sale of
depleted zinc and other products. We recognized operating losses for the year
ended April 30, 2000, of approximately $2,401,000, and for the six months
ended October 31, 2000, of approximately $2,583,000. We recognized net income
for the year ended April 30, 2000, only because of the gain recognized on the
sale of our depleted zinc assets to Eagle-Picher.

         The depleted zinc business had accounted for a significant portion
of our revenues during prior fiscal years. Following the sale of our depleted
zinc business, our primary risk is our reliance on products that have to date
not produced significant revenues. We have historically, and expect to
continue to, operate with little backlog and a significant portion of our net
revenues have been, and we believe will continue to be, derived from a
limited number of orders that are processed and shipped in the same quarter
in which the orders are received. The timing of such orders and their
fulfillment has caused, and is likely to continue to cause, material
fluctuations in our operating results. Our expense levels are relatively
fixed, and prior quarters have indicated these factors will affect our
operating results for future periods.

         We are engaging in research and development to diversify our
business and to expand other lines of our business. We are now seeking to
identify and evaluate a variety of new stable isotope products and potential
markets for economic and technical feasibility. We will continue to fund
research and development to improve technologies for isotope separation and
materials processing technologies. During fiscal 2000, 1999, and 1998,
research and development expenses were $1.224 million, $1.155 million, and
$811,000, respectively. For the six months ended October 31, 2000, research
and development expenses were $716,000. We cannot offer any assurance that
our current or future lines of business and our research and development
efforts will be profitable. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and
"BUSINESS."


RELATIONSHIP WITH CERTAIN SUPPLIERS AND AVAILABILITY OF RAW MATERIALS

         We depend on an isotope enrichment plant, located in Russia, which
is owned by the Ministry of Atomic Energy of the Russian Federation (the
"Ministry"), which is part of the cabinet of the government of the Russian
Federation, for most of our stable and radioisotopes. We signed an agreement
with the commercial department of the Ministry to purchase certain isotope
separation services through 2001. Disruption or termination of services
provided by the Ministry could have a material and adverse affect upon our
financial condition and



results of operations.

         Related to, but separate from, the sale of the depleted zinc
business, we contemporaneously signed a ten-year Supply Agreement by which we
will have the exclusive right to purchase quantities of isotopically pure
silicon-28, silicon-29, and silicon-30, and a non-exclusive right to purchase
quantities of isotopically pure carbon-12 and carbon-13 produced by
Eagle-Picher from its current and planned facilities in Oklahoma. The Supply
Agreement locks-in what we believe is a favorable purchase price for the
aforementioned isotopes. As partial consideration for the exclusivity
provision, we agreed to pay Eagle-Picher a fee equal to 3.0% of the net
revenues from all sales made by us of products incorporating enriched silicon
isotopes supplied by Eagle-Picher.

                  To date Eagle-Picher has failed to deliver any silicon-28
to us, and we have no assurance that Eagle-Picher will be able to deliver any
silicon-28 to us in the future. We know that Eagle-Picher's silicon-28
production facility in Oklahoma has encountered certain technical
difficulties, which Eagle-Picher refers to as a FORCE MAJEURE. We believe
that Eagle-Picher's technical difficulties do not meet the definition of
FORCE MAJEURE per our agreements, which would entitle Eagle-Picher to a delay
in the delivery requirement. We have commenced pursuing the dispute
resolution mechanisms as set forth in the agreement with Eagle-Picher to
address this and other related matters. As of January 12, 2001, we have held
several discussions with the designated members of Eagle-Picher's management
as called for in the first step of the dispute resolution process. If these
discussions do not result in a satisfactory outcome, it is our intention to
proceed to the second step of the dispute resolution process, mediation, and
we have informed Eagle-Picher of our intentions. Eagle-Picher's
non-performance under our agreement may force us to seek other suppliers of
silicon-28. There can be no assurance that these suppliers can produce
sufficient quantities of silicon-28 at reasonable prices to make silicon-28
commercially viable. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and
"BUSINESS."


LIMITED SOURCES FOR RAW MATERIALS

         Stable isotopes constitute the principal raw material required for
the manufacture of our products. The principal sources for enriched stable
isotopes are suppliers in Russia, the Republic of Uzbekistan ("Uzbekistan"),
and the Republic of Georgia ("Georgia"). Oak Ridge National Laboratory in Oak
Ridge, Tennessee, which relies on government funding for continuing
production, and certain foreign facilities in the world including private and
pseudo-governmental organizations in Great Britain, Germany, The Netherlands,
and the Republic of South Africa, have the potential to produce stable
isotopes, and in certain cases, actually produce isotopes. Although
currently, enriched stable isotopes are also available from additional
foreign sources, there can be no assurance that there will continue to be an
adequate supply of enriched stable isotopes. Although we expect that our
current supply contracts will be sufficient to produce most isotopes, the
production processes require various proprietary separation techniques, which
although developed by our suppliers, may not have all been tested to date and
as to the success of which there can be no assurance. These limited sources
of raw materials may result in an inability to deliver enriched stable
isotopes, radioisotopes, or other isotope products in accordance with our
contractual requirements (whether or not the failure is our fault) and
possibly resulting in liability related to such failure. SEE "MANAGEMENT'S
DISCUSSION AND ANALYSIS" and "BUSINESS."


OPERATIONS IN RUSSIA, THE REPUBLIC OF UZBEKISTAN, AND THE REPUBLIC OF GEORGIA

         Operations in Russia, the Republic of Uzbekistan, and the Republic
of Georgia entail certain risks. Recently, the former republics of the Soviet
Union including Uzbekistan and Georgia have experienced political, social,
and economic change as they obtained independence from the former central
government in Moscow. Certain of the republics, including Russia, Uzbekistan,
and Georgia, have attempted to transition from a central-controlled economy
toward a market-based economy. These changes have involved, in certain cases,
armed conflict. The political or economic instability in these republics may
continue or even worsen. The supply of




stable isotopes could be directly affected by political, economic, and
military conditions in Russia, Uzbekistan, and Georgia. Accordingly, our
operations could be materially adversely affected if hostilities in Russia,
Uzbekistan, or Georgia should occur, if trade between Russia, Uzbekistan,
and/or Georgia and the United States were interrupted, if political
conditions in Russia, Uzbekistan, or Georgia disrupt transportation or
processing of our goods, if laws or government policies concerning foreign
business operations in Russia, Uzbekistan, or Georgia change substantially,
or if tariffs are introduced. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS" and
"BUSINESS."


DEPENDENCE ON FUTURE PRODUCT DEVELOPMENT

         On December 1, 1999, we sold our depleted zinc business, which
provided 21% and 35% of our revenues in fiscal 2000 and 1999, respectively.
As a result, our future operations will be more heavily dependent upon our
ability to develop new products using stable and radioactive isotopes, and to
market and sell those products profitably. While we have a high degree of
confidence we can be successful, we can expect to incur significant operating
losses until we are able to do so. Our ability to develop, market, and sell
these products will depend on our suppliers' (including Eagle-Picher) ability
to meet our demand for stable and radioactive isotopes, as well as, other
suppliers who modify the chemical and physical forms of these isotopes. There
can be no assurance that we will be able to develop products that can be
profitably marketed and sold. SEE "BUSINESS."


CUSTOMER CONCENTRATION

         Prior to fiscal 1999, substantially all of our net revenues in any
particular period were attributable to a limited number of customers,
primarily General Electric Corporation. Consistent with our historical
experience, our quarterly results during fiscal year 2000 were affected
materially by the level of orders received from a limited number of
significant depleted zinc users during such quarters, and product shipments
by us to our depleted zinc customers during such periods. Despite the sale of
the depleted zinc business, we continue to be subject to a certain degree of
variability based on the timing of sales of our stable and radioactive
isotope orders. We cannot be assured that our principal customers will
continue to purchase our products. A decrease in or loss of orders from one
or more major customers would have a material and adverse effect on our
financial condition and results of operations. SEE "MANAGEMENT'S DISCUSSION
AND ANALYSIS" AND "BUSINESS."

         While our goal is to diversify our customer base, we expect to
continue to depend upon a relatively small number of customers for a
significant percentage of our revenues for the foreseeable future.
Significant reductions in sales to any of our large customers have had, and
may in the future have, a material adverse effect on us. We cannot guarantee
that present or future customers will not terminate their arrangements with
us or significantly change, reduce, or delay the amount of isotope products
ordered from us. A termination of a customer relationship, or change,
reduction, and/or delay in orders could materially harm us.


FACTORS AFFECTING OPERATING RESULTS; VARIABILITY OF ORDERS

         We operate with little backlog. A significant portion of our net
revenues have been, and we believe will continue to be, derived from a
limited number of orders that are processed and shipped in the same quarter
in which the orders are received. The timing of such orders and their
fulfillment has caused, and is likely to continue to cause, material
fluctuations in our operating results. Our expense levels are relatively
fixed, and as has been the case in prior quarters, these factors will affect
our operating results for future periods. SEE "MANAGEMENT'S DISCUSSION AND
ANALYSIS."


MANAGEMENT OF GROWTH



         We have experienced, and may again experience, periods of rapid
growth that have placed a significant strain on our financial and managerial
resources. Our ability to manage growth effectively, particularly given our
increasing scope of operations, will require us to continue to implement and
improve our management, operational, and financial information systems, as
well as to develop the management skills of our personnel and to train,
motivate and manage our employees. Our failure to effectively manage growth
could have a material adverse effect on our business, financial condition,
and results of operations. SEE "BUSINESS."


DEPENDENCE ON KEY PERSONNEL

         Our future success will depend in significant part upon the
continued service of our key technical, sales and senior management
personnel, including James E. Alexander, our President and Chief Executive
Officer; Boris Rubizhevsky, our Senior Vice President, Isotope Production and
Supply; Robert Cuttriss, President of Interpro; and Herbert Hegener, Managing
Director of Chemotrade. We maintain $1,000,000 of key man life insurance on
the lives of Messrs. Alexander, Rubizhevsky, and Cuttriss, and all are
covered by employment agreements extending through September 2001, 2002, and
2003, respectively (although the individuals may terminate these agreements
prematurely at their discretion). Mr. Hegener is covered by an employment
agreement extending through the year 2001. We believe that our future success
will depend in large part upon our ability to attract and retain qualified
personnel for our operations. The failure to attract or retain such persons
could materially adversely affect our business, financial condition, and
results of operations. SEE "MANAGEMENT."


NEED FOR ADDITIONAL FINANCING

         We had anticipated no need for additional financing in the current
fiscal year, but we had anticipated a need for a substantial amount of
financing after our current fiscal year ending April 30, 2001. Circumstances
beyond our control led us to need additional financing sooner than we
anticipated, and it is possible that these and other circumstances that may
develop may lead to a need for further financing.

     o   delays in Eagle-Picher's production of silicon and carbon isotopes from
         its plant in Oklahoma, and the resulting delays in their delivery of
         the isotopes to us under the terms of the supply agreement;

     o   unanticipated expenses in developing our new products or in producing
         or marketing our existing products;

     o   the necessity of having to protect and enforce our intellectual
         property rights;

     o   technological and market developments; and

     o   a corporate decision to expand our production capacity through capital
         investment or acquisition.


         As discussed above and in more detail below, the first factor,
relating to Eagle-Picher has become a reality when Eagle-Picher failed to
deliver silicon-28 to us by December 31, 2000, in accordance with its
contractual obligation; in what we believe to be an effort to enhance its
negotiating position with us, Eagle-Picher failed to make a $500,000 payment
due us on November 30, 2000, from the sale of the depleted zinc business.
These are two of several disputes between us and Eagle-Picher, which are
discussed in more detail below.

         We have also had a customer fail to pay approximately $218,000 due
us for products sold in the quarter



ended October 31, 2000. These events have resulted in a significant decrease
in our working capital position. We have filed suit to collect these funds.

         To alleviate cash shortages resulting from the foregoing, on
December 13, 2000, we sold 337,500 units consisting of one share of our
Common Stock and two Class B warrants for $675,000 to a group of accredited
investors. Unless we are able to collect the amounts due us from Eagle-Picher
and the other customer, we may need to seek additional capital before the end
of the current fiscal year. If we need the additional capital, there is no
assurance that we will be able to obtain it through a private placement or
otherwise.

         The exercise of the Class A Warrants, the Class B Warrants, and/or
the Class C Warrants will provide us with some additional financing, but we
cannot offer any assurance that any warrants will be exercised. The
unavailability of additional financing, when needed, could have a material
adverse effect on our business. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS"
AND "BUSINESS."


NO ASSURANCE AS TO VALIDITY OF INTELLECTUAL PROPERTY RIGHTS

         We rely primarily on a combination of trade secrets, confidentiality
procedures, and contractual provisions to protect our technology. Despite our
efforts to protect our rights, unauthorized parties may attempt to copy
aspects of our products or to obtain and use information that we regard as
proprietary. Policing unauthorized use of our technology and products is
difficult. In addition, the laws of many countries do not protect our rights
in information, materials, and intellectual property that we regard as
proprietary, and that are protected under the laws of the United States.
There can be no assurance that our means of protecting our rights in
proprietary information, materials, and technology will be adequate, or that
our competitors will not independently develop similar information,
technology, or intellectual property. SEE "BUSINESS."

         We currently have no patents in our own name and have not filed any
patent applications. We have rights to several isotopically engineered
innovations regarding electronic and optical materials that we believe may be
patentable. Ongoing work in the area of isotope separation by chemical means
may also lead to patentable inventions. In such cases, we intend to file
patent applications for some of these modifications, improvements, and
inventions and to protect others as trade secrets. There can be no assurance,
however, that patents on such modifications, improvements, or inventions will
be issued, or if issued, that such patents or modifications and improvements
protected as trade secrets will provide meaningful protection.

         Third parties may have filed applications for or have been issued
patents and may obtain additional patents and proprietary rights related to
products or processes competitive with or similar to those of Isonics. We may
not be aware of all patents potentially adverse to our interests that may
have been issued to others and there can be no assurance that such patents do
not exist or have not been filed, or may not be filed or issued. If patents
have been, or are issued to others containing preclusive or conflicting
claims, and such claims are ultimately determined to be valid, we may be
required to obtain licenses thereto, or to develop or obtain alternate
technology. There can be no assurance that such licenses, if required, would
be available on commercially acceptable terms, if at all, or that we would be
able to develop or obtain alternate technology, which would have a material
adverse effect on our business.

         There can be no assurance that the validity of any of the patents
licensed to, or that may in the future be owned by us, would be upheld if
challenged by others in litigation or that our products or technologies, even
if covered by our patents, would not infringe upon patents owned by others.
We could incur substantial costs in defending suits brought against us, or
any of our licensors, for infringement, in suits by us against others for
infringement, or in suits contesting the validity of a patent. Any such
proceedings may be protracted. In any suit contesting the validity of a
patent, the patent being contested would be entitled to a presumption of
validity and the contesting party would be required to demonstrate invalidity
of such patent by clear and convincing evidence. If



the outcome of any such litigation were adverse to our interests, our
business would be materially adversely affected.

         In certain instances, we may choose not to seek patent protection
and may rely on trade secrets and other confidential know-how to protect our
innovations. There can be no assurance that protectable trade secrets or
know-how will be established, or if established, that they will remain
protected or that others will not independently and lawfully develop similar
or superior innovations. We require all employees to sign intellectual
property assignment and non-disclosure agreements. In certain instances, we
will enter into agreements with our employees pursuant to which the employee
will be entitled to a small royalty with respect to products developed by
Isonics based upon the employee's inventions. In addition, all directors,
consultants, and other parties to whom confidential information has been, or
will be, disclosed have or will execute agreements containing confidentiality
provisions. There can be no assurance, however, that any such intellectual
property assignment agreements and confidentiality agreements will be
complied with or will be enforceable.


COMPETITION AND RISK OF TECHNOLOGICAL OBSOLESCENCE

         Within the United States, we believe there currently is no producer
of a full range of stable enriched isotopes for commercial sale. The U.S.
government produces isotopes, but primarily for research purposes. There can
be no assurance that a third party will not contract with the U.S. government
to acquire isotopes for commercial sale. Outside the United States, many
countries and businesses produce stable and radioactive isotopes. Some of
these businesses have substantially greater capital and other resources than
do we. SEE "BUSINESS."

         Further, it is possible that future technological developments may
occur, and these developments may render our radioisotopes and stable
isotopes obsolete or non-competitive. Rapidly changing technology and
continuing process development characterize the market for our isotope
products. We believe that our future success will depend in large part upon
our ability to develop and market isotope products, which meet changing
customer needs, maintain technological leadership, and successfully
anticipate or respond to technological changes in isotope product technology
on a cost-effective and timely basis. We cannot guarantee that our product
development efforts will be successful.

         In the future, we may face substantial competition, and we may not
be able to compete successfully against present or future competitors.


ENVIRONMENTAL COMPLIANCE

         We are subject to a variety of federal, state, and local
environmental regulations relating to the use, storage, discharge, and
disposal of hazardous chemicals used during the isotope product delivery and
manufacturing process. While we believe that we are in compliance with all
environmental regulations, if we fail to comply with present and future
regulations we could be subject to future liabilities or the suspension of
production. In addition, these regulations could restrict our ability to
expand our facilities or could require us to acquire costly equipment or to
incur other significant expenses to comply with governmental regulations.
Historically, our costs of compliance with environmental regulations have not
been material. In the quarter ended October 31, 2000, we recognized a
$270,000 expense to remediate the Golden, Colorado facility we currently
lease. These costs will be paid prior to the expiration of our lease in June
2001 unless we are able to sell our Interpro subsidiary before then and the
purchasers assume this obligation. SEE "BUSINESS."


CONTROL BY DIRECTORS AND OFFICERS



         Even if all of the Class A Warrants, Class B Warrants, and Class C
Warrants are exercised (which we cannot assure), our directors and officers
will beneficially own between 34.4% and 39.9% of the outstanding shares of
Common Stock as of January 17, 2001, and, accordingly, will have the ability
to elect a majority of the directors of Isonics and otherwise control the
company. SEE "SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT."



- ---------------------------------------------- -------------------------------------------- ---------------------------------------
Description                                    Number of New Common Stock Shares            Beneficial Ownership by Directors and
                                                                                            Officers
- ---------------------------------------------- -------------------------------------------- ---------------------------------------
                                                                                      
Current Ownership*                             N/A                                          42.4%
- ---------------------------------------------- -------------------------------------------- ---------------------------------------
Class A Warrants Exercised**                   810,000                                      39.9%
- ---------------------------------------------- -------------------------------------------- ---------------------------------------
Class A Warrants and Class B Warrants          1,485,000                                    38.0%
Exercised**
- ---------------------------------------------- -------------------------------------------- ---------------------------------------
Class A Warrants, Class B Warrants, and        2,970,000                                    34.4%
Class CB Warrants Exercised**
- ---------------------------------------------- -------------------------------------------- ---------------------------------------


* The current number of Common Stock shares owned by directors and officers is
4,618,204. The current number of Common Stock shares outstanding is 12,000,056.
The current number of options and warrants exercisable owned by directors and
officers is 816,685.
** Assumes 100% exercise.


PRODUCT LIABILITY EXPOSURE AND INSURANCE

         The use of our radioisotopes in radiopharmaceuticals and in clinical
trials may expose us to potential product liability risks that are inherent
in the testing, manufacture, marketing, and sale of human diagnostic and
therapeutic products. We currently have product liability insurance; however,
there can be no assurance that a product liability or other claim would not
materially and adversely affect our business or financial condition. SEE
"BUSINESS."


PRICE VOLATILITY

         The trading price of our securities has been subject to wide
fluctuations in response to quarter-to-quarter variations in operating
results, our announcements of technological innovations or new products by us
or our competitors, and other events or factors. The securities markets have
from time to time experienced significant price and volume fluctuations that
may be unrelated to the operating performance of particular companies.
Announcements of delays in our testing and development schedules,
technological innovations or new products by us or our competitors,
developments or disputes concerning patents or proprietary rights, regulatory
developments in the United States and foreign countries, public concern as to
the safety of products containing radioactive compounds and economic and
other external factors, as well as period-to-period fluctuations in our
financial results, may have a significant impact on the market price of our
securities. In addition, the realization of any of the risks described in
these "Risk Factors" could have a significant and adverse impact on such
market prices. SEE "MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS."


PENNY STOCK REGULATIONS

         Although our Common Stock (and Class A Warrants) are currently
quoted on the Nasdaq SmallCap



Market, our Common Stock has in the past been subject to additional
disclosure requirements for penny stocks mandated by the Securities
Enforcement Remedies and Penny Stock Reform Act of 1990. The SEC Regulations
generally define a penny stock to be an equity security that has a market
price of less than $5.00 per share, not including shares quoted on the Nasdaq
Stock Market such as our Common Stock. We have, at times in the past, been
included within the SEC Rule 3a-51 definition of a penny stock. When our
Common Stock is considered to be a "penny stock", trading is covered by Rule
15g-9 promulgated under the Securities Exchange Act of 1934, for non-Nasdaq
and non-national securities exchange listed securities. Under this rule,
broker-dealers who recommend such securities to persons other than
established customers and accredited investors must make a special written
disclosure to, and suitability determination for, the purchaser and receive
the purchaser's written agreement to a transaction prior to sale. The
regulations on penny stocks limit the ability of broker-dealers to sell our
Common Stock and thus the ability of purchasers of our Common Stock to sell
their securities in the secondary market. To the extent we are able to
maintain our listing on the Nasdaq SmallCap Market, we will not be subject to
these penny stock rules. SEE "MARKET FOR COMMON EQUITY AND RELATED
STOCKHOLDER MATTERS."


POTENTIAL ADVERSE MARKET IMPACT OF SHARES ELIGIBLE FOR FUTURE SALE

         Our stock price may be hurt by future sales of our shares or the
perception that such sales may occur. As of January 17, 2001, approximately
8,000,775 shares of Common Stock held by existing stockholders constitute
"restricted shares" as defined in Rule 144 under the Securities Act. These
shares may only be sold if they are registered under the Securities Act, or
sold under Rule 144, or another exemption from registration under the
Securities Act. Sales under Rule 144 are subject to the satisfaction of
certain holding periods, volume limitations, manner of sale requirements, and
the availability of current public information about us.

         A substantial portion of all of our restricted shares of Common
Stock are either eligible for sale pursuant to Rule 144 or have been
registered under the Securities Act for resale by the holders. This will
permit the sale of registered shares of Common Stock in the open market or in
privately negotiated transactions without compliance with the requirements of
Rule 144. We are unable to estimate the amount, timing, or nature of future
sales of outstanding Common Stock. Sales of substantial amounts of our Common
Stock in the public market may hurt the stock's market price. SEE "SHARES
AVAILABLE FOR FUTURE SALE."


EFFECT OF OUTSTANDING SERIES A PREFERRED STOCK, OPTIONS, AND WARRANTS

         As of January 17, 2001, we had outstanding preferred stock
convertible into, and options and warrants to purchase, an aggregate of
6,723,208 shares of Common Stock. As long as these shares of convertible
preferred stock ("Series A Convertible Preferred Stock") remain outstanding
and the options and warrants remain unexercised, the terms under which we
could obtain additional capital may be adversely affected. Moreover, the
holders of the Series A Convertible Preferred Stock, options, and warrants
may be expected to exercise them at a time when we would, in all likelihood,
be able to obtain any needed capital by a new offering of our securities on
terms more favorable than those provided by these securities. SEE "ISONICS'
CAPITAL STOCK."


ANTI-TAKEOVER PROVISIONS

         Our Articles of Incorporation authorize the issuance of "blank
check" preferred stock with such designations, rights, and preferences, as
may be determined by our Board of Directors. Accordingly, the Board of
Directors may, without shareholder approval, issue shares of preferred stock
with dividend, liquidation, conversion, voting, or other rights that could
adversely affect the voting power or other rights of the holders of our
Common Stock. Preferred stock could also be issued to discourage, delay, or
prevent a change in our control, although we do not currently intend to issue
any additional series of our preferred stock. SEE "ISONICS' CAPITAL



STOCK."


INDEMNIFICATION OF OFFICERS AND DIRECTORS

         Our Bylaws provide for indemnification of officers and directors to
the full extent permitted by California law, our state of incorporation. We
may be required to pay certain judgments, fines, and expenses incurred by an
officer or director, including reasonable attorneys' fees, as a result of
actions or proceedings in which such officers and directors are involved by
reason of being or having been an officer or director. SEE "SECURITIES AND
EXCHANGE COMMISSION POSITION ON INDEMNIFICATION FOR SECURITIES ACT
LIABILITIES."


NO DIVIDENDS ANTICIPATED TO BE PAID

         We have never paid any cash dividends on our Common Stock and we do
not anticipate paying cash dividends on our Common Stock in the future. The
future payment of dividends is directly dependent upon our future earnings,
capital requirements, financial requirements, and other factors to be
determined by our Board of Directors. It is anticipated that future earnings,
if any, which may be generated from our operations, will be used to finance
our growth, and that cash dividends will not be paid to our stockholders. SEE
"MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS."


LACK OF ADEQUATE AUTHORIZED CAPITAL STOCK

As a result of the December 13, 2000, completion of a private placement to a
group of accredited investors, we issued a total of 337,500 shares of our
Common Stock and 675,000 Class B warrants. Additionally, if all of the
675,000 Class B warrants are exercised we will issue an additional 675,000
Class C warrants. This private placement increased our shares of Common Stock
outstanding to 12,000,056.

As described above, we also have 980,333 shares of Series A Convertible
Preferred Stock outstanding, options outstanding of 1,107,852, and warrants
outstanding of 4,635,023 (this includes 675,000 restricted Class B Warrants.)
Additionally, we have reserved Common Stock shares as follows: 1,485,000 upon
the possible conversion of Class C warrants (none of which are currently
outstanding), 796,779 shares reserved for our Employee Stock Option Plans,
and 172,063 shares of Common Stock reserved for our Employee Stock Purchase
Plan. The total of these outstanding shares of Common Stock, equity
instruments convertible and exercisable into Common Stock, and reserved
shares of Common Stock is 21,177,106. This exceeds our authorized capital of
20,000,000 by 1,177,106 shares of Common Stock.

Since our authorized Common Stock is only 20,000,000 shares, we will not be
able to issue any shares in excess of 20,000,000, and we may become liable
for our inability to issue shares as we have committed to do. We intend to
propose an amendment to our Articles of Incorporation to increase our
authorized capital as a special meeting of shareholders, which we expect to
hold in March or April 2001. However, there can be no assurance that we will
be able to obtain approval of an increase in our authorized capitalization
from our shareholders at the meeting when held. Until then, and thereafter,
if the shareholders do not approve the increase we are potentially liable for
our inability to issue all shares as committed. We do not believe that the
lack of authorized capital will impact the ability of any person to exercise
the Class B Warrants or the Class C Warrants.


RISK OF FORWARD-LOOKING INFORMATION

         We have included a significant amount of forward-looking information
in this prospectus. Because it is not



possible to predict the future, there is a significant risk that the
forward-looking information will prove to be incorrect, and perhaps
materially incorrect. SEE "SUMMARY-A NOTE ABOUT FORWARD-LOOKING STATEMENTS."


                              THE EXCHANGE OFFER

BACKGROUND OF AND REASONS FOR THE EXCHANGE OFFER

         In connection with our underwritten initial public offering
completed in September 1997, an underwriter sold 810,000 Units. Each Unit
consisted of 810,000 shares of Common Stock and 810,000 Class A Warrants.
Each Class A Warrant entitles the holder to purchase one share of Common
Stock through September 21, 2001. The Class A Warrants expire at 5:00 p.m. on
September 21, 2001, and the Class A Warrants will then become valueless. As
of January 17, 2001, no person has exercised any Class A Warrants.

         At the time we completed our initial public offering, we also sold
80,000 additional warrants to the underwriter (the "Underwriters' Warrants"),
all of which remain outstanding. The holders of the Underwriters' Warrants
are entitled to exercise these warrants by paying us $9.57 per warrant, and
the holders will then receive a single share of our Common Stock and a Class
A Warrant. In order for any person holding an Underwriters' Warrant to
participate in the warrant exchange, he or she will have to first exercise
the Underwriters' Warrant and then submit the Class A Warrants received for
exchange.

         We are offering holders of outstanding Class A Warrants the
opportunity to exchange their Class A Warrants for Class B Warrants in order
to equate the exercise and redemption provisions of our outstanding warrants
with the current market prices for our Common Stock. As an incentive to
encourage exchange, each Class B Warrant is exercisable for one share of
Common Stock, and one additional Class C Warrant to purchase one share of
Common Stock, and the exercise prices for the Class B Warrants and the Class
C Warrants are lower than the current exercise price for the Class A
Warrants. Persons who exchange their Class A Warrants will be entitled to
exercise their warrants for a longer period of time, and at a lower exercise
price, than those who do not exchange their Class A Warrants for Class B
Warrants (since the Class A Warrants expire September 21, 2001, and are
exercisable for $5.80 while the Class B Warrants expire December 31, 2005,
and are exercisable for $1.50.)


PURPOSE OF THE EXCHANGE OFFER

         We are offering holders of our outstanding Class A Warrants the
opportunity to exchange their Class A Warrants for Class B Warrants. We are
doing so to provide our Class A Warrant holders with an opportunity to
acquire warrants with a lower exercise price, a longer term, and additional
value, while also providing Isonics with redemption provisions which it may
be able to utilize in the future to encourage the exercise of the outstanding
warrants. As an incentive, each Class B Warrant is exercisable for one share
of Common Stock, at a lower exercise price ($1.50 versus $5.80) and one Class
C Warrant. We also hope that the exchange may have a positive effect on the
liquidity of, and the public market for, our Common Stock by increasing the
number of publicly-held shares of our Common Stock, although we cannot be
sure whether the exchange offer will have this or any other beneficial
effect. The following chart sets forth the principal differences between the
Class A Warrants, the Class B Warrants, and the Class C Warrants. This chart
is only a summary, and for further information you should review:

         o    the Warrant Agreement dated September 22, 1997, between Isonics
              and Continental Stock Transfer & Trust Company, Inc. for the
              Class A Warrants; and

         o    the Warrant Agreement dated June 1, 2000, between Isonics and
              Continental Stock Transfer &



              Trust Company, Inc. for the Class B Warrants and Class C
              Warrants, as amended and restated, effective January 15, 2001.

         SUMMARY OF DIFFERENCES BETWEEN THE WARRANTS



                                      CLASS A WARRANTS                  CLASS B WARRANTS           CLASS C WARRANTS (issuable only
                                                                                                         upon the exercise of
                                                                                                          Class B Warrants)
                                                                                         

Expiration Date              September 21, 2001                 December 31, 2005                 December 31, 2005

Exercise Price               $5.80                              $1.50                             $2.50

Product of Exercise          Each person exercising a Class A   Each person exercising a Class B  Each person exercising a Class C
                             Warrant will receive one share of  Warrant will receive one share    Warrant will receive one share of
                             Common Stock and one Class C       of Common Stock and one Class C   Common Stock
                             Warrant if exercised before April  Warrant
                             30, 2001

Redemption Provisions        We may redeem the Class A          We may redeem the Class B         We may redeem the Class C
                             Warrants at a price of $0.10 per   Warrants at a price of $0.10 per  Warrants at a price of $0.10 per
                             Warrant on not less than 30 days'  Warrant, on or after May 1,       Warrant on not less than 30 days'
                             prior written notice if the        2001, on not less than 30 days'   prior written notice if our
                             average price of the Common Stock  prior written notice if our       Common Stock trades at or above
                             has been at least $14.50 per       Common Stock trades at or above   $3.75 per share (subject to
                             share (subject to adjustment) for  $3.75 per share (subject to       adjustment) for any 20 of 30
                             at least 20 consecutive trading    adjustment) for any 20 of 30      consecutive trading days ending
                             days ending within three days      consecutive trading days ending   not more than three days before
                             prior to the date on which notice  not more than three days before   the notice of redemption is
                             of redemption is given.            the notice of redemption is       deposited in the United States
                                                                deposited in the United States    mails.
                                                                mails.

Dilution Provisions          The number of shares of Common     The Class B Warrants will be      The Class C Warrants will be
                             Stock issuable upon exercise is    subject to similar dilution       subject to similar dilution
                             subject to adjustment in a number  adjustment provisions             adjustment provisions
                             of circumstances

Ability to Trade             The Class A Warrants have          A public market may develop for   A public market may develop for
                             historically traded on the         the Class B Warrants.  There can  the Class C Warrants.  There can
                             Over-The-Counter Bulletin Board,   be no assurance that a market     be no assurance that a market for
                             and on the Nasdaq SmallCap Market  for the Class B Warrants will     the Class C Warrants will develop
                             since July 2000.  There can be no  develop or, if it develops, will  or, if it develops, will
                             assurance that the market          continue.  We have                continue.  We have



                             will continue.                     applied for trading on the        applied for trading on the
                                                                Nasdaq SmallCap Market.           Nasdaq SmallCap Market.

Registration                 The Class A Warrants are           The Class B Warrants are also     The Class C Warrants are also
                             registered under the Securities    registered under the 1934 Act.    registered under the 1934 Act.
                             Exchange Act of 1934, as amended.

Warrant Holders are not      Holders of Class A Warrants are    Holders of Class B Warrants are   Holders of Class C Warrants are
   shareholders              not considered to be Shareholders  not considered to be              not considered to be Shareholders
                             of Isonics, and do not have the    Shareholders of Isonics, and do   of Isonics, and do not have the
                             right to vote at shareholders'     not have the right to vote at     right to vote at shareholders'
                             meetings or to receive dividends   shareholders' meetings or to      meetings or to receive dividends
                             when and if declared.              receive dividends when and if     when and if declared.
                                                                declared.



         If all Class A Warrants are exchanged, we will issue an aggregate of
810,000 Class B Warrants (890,000 if the holders exercise the Underwriters'
Warrants and exchange the Class A Warrants received). All Class A Warrants
submitted for exchange will be cancelled.

         If a holder exercised his or her Class A Warrant prior to or during
this exchange offer, we will issue a Class C Warrant to that person for no
additional consideration. However, a person exercising a Class A Warrant will
pay a substantially higher price ($5.80 per share) than were that person to
exchange the Class A Warrant for a Class B Warrant and then exercise the
Class B Warrant at $1.50 per share. We will not refund the difference to any
person who exercises their Class A Warrants.


RECOMMENDATION OF THE BOARD OF DIRECTORS

         The Board of Directors believes that this exchange offer is in the
best interests of Isonics and holders of Class A Warrants, and recommends
that holders of Class A Warrants participate in the exchange offer


CONSEQUENCES OF FAILURE TO EXCHANGE

         There are significant consequences if you fail to exchange your
Class A Warrants before the expiration date of the exchange offer and the
expiration date of the Class A Warrants, as the Class B Warrants have a much
lower exercise price, have added value in the nature of the Class C Warrants
to be issued upon exercise of the Class B Warrants, and provide you a longer
exercise period (through December 31, 2005, subject to our right to call the
Warrants for redemption). After the expiration of the exchange offer on April
30, 2001, unless extended, you will no longer have a right to exchange your
Class A Warrants for Class B Warrants or otherwise obtain a Class C Warrant.


EXPIRATION TIME, EXTENSION, AMENDMENTS

         The exchange offer will expire at 5:00 p.m., New York Time, on April
30, 2001, unless the expiration time is extended at the discretion of the
Board of Directors.

         Notwithstanding the foregoing, Isonics expressly reserves the right
in its sole and absolute discretion, subject to applicable law, at any time
and from time to time:




         o    to delay the acceptance of the Class A Warrants for exchange;

         o    to terminate the exchange offer at any time (whether or not any
              Class A Warrants have been accepted for exchange);

         o    to extend the expiration time of the exchange offer and retain
              all Class A Warrants tendered, or to offer withdrawal rights on
              a case-by-case basis; and

         o    to waive any condition or otherwise amend the terms of the
              exchange offer in any respect.


         If this exchange offer is amended in a manner determined by us to
constitute a material change, or if we waive a material condition of the
exchange offer, we will promptly notify the exchange agent. We will also make
a public announcement of any extension no later than 9:00 a.m., New York
Time, on the business day immediately following the previously scheduled
expiration date. Without limiting the manner in which we may choose to make
any public announcement and subject to applicable law, we shall have no
obligation to publish, advertise, or otherwise communicate any such public
announcement other than by issuing a release to an appropriate news agency.
If Isonics makes a material change to the exchange offer, we will extend the
exchange to the extent required by law.


TERMS OF THE EXCHANGE AND PROCEDURE FOR SUBMITTING CLASS A WARRANTS

         For each Class A Warrant validly submitted for exchange, we will
issue one Class B Warrant. The terms of the Class B Warrant are as follows:

         o    we will issue to the holder who exercises a Class B Warrant one
              share of Common Stock and one Class C Warrant;

         o    the exercise price of the Class B Warrants is $1.50 per Class B
              Warrant (subject to adjustment);

         o    the Class B Warrants will expire on December 31, 2005;

         o    because of the applicability of state securities laws, only
              residents of certain states as set forth on the cover page of
              this prospectus are permitted to exchange their Class A
              Warrants, or exercise their Class B Warrants; and

         o    the Class B Warrants will be redeemable, on or after May 1,
              2001, if our Common Stock trades at or above $3.75 per share
              (subject to adjustment) for any 20 of 30 consecutive trading
              days ending not more than three days before the notice of
              redemption is deposited in the United States mails.

         As set forth above, each person who exercises a Class B Warrant (or
who has previously exercised a Class A Warrant) will receive a Class C
Warrant. The terms of the Class C Warrants are as follows:

         o    we will issue to the holder who exercises a Class C Warrant one
              share of Common Stock;

         o    the exercise price of the Class C Warrants is $2.50 per Class C
              Warrant (subject to adjustment);

         o    the Class C Warrants will expire on December 31, 2005;



         o    because of the applicability of state securities laws, only
              residents of certain states as set forth on the cover page of
              this prospectus will be permitted to exercise their Class C
              Warrants; and

         o    the Class C Warrants will be redeemable if our Common Stock
              trades at or above $3.75 per share (subject to adjustment) for
              any 20 of 30 consecutive trading days ending not more than
              three days before the notice of redemption is deposited in the
              United States mails.

         The Class B Warrants and Class C Warrants and the underlying shares
of Common Stock have been registered under the Securities Act. All share and
warrant certificates will be registered in the exact same name as the
original certificates.

         The exchange offer is not conditioned upon any minimum number of
Class A Warrants being submitted for exchange. As of the date of this
prospectus, 810,000 Class A Warrants were outstanding, and an additional
80,000 Class A Warrants are issuable upon exercise of the outstanding
Underwriters' Warrants.

         No person has any appraisal or dissenters' rights in connection with
the exchange offer. Class A Warrants, which are not submitted for exchange,
or are submitted but not accepted for exchange will remain outstanding. After
this exchange offer expires (the same date that the Class A Warrants expire),
holders of Class A Warrants will not have an opportunity to exchange their
Class A Warrants and their investment will be valueless. We do not intend to
make another exchange offer with respect to any Class A Warrants outstanding
after the expiration of this exchange offer, nor do we intend to extend the
expiration date of the Class A Warrants.

         If any Class A Warrants are not accepted for exchange because of an
invalid tender, the occurrence of certain other events set forth herein or
otherwise, certificates for any such unaccepted securities will be returned,
without expense, to the holder promptly after the expiration date. Holders
who submit Class A Warrants will not be required to pay brokerage commissions
or fees or, subject to the instructions in the Letter of Transmittal,
transfer taxes with respect to the exchange offer.

         In order to make a valid delivery for exchange of Class A Warrants,
a holder must deliver the certificates representing such securities, together
with a properly completed and executed Letter of Transmittal (or copy
thereof), including all required signatures, signature guarantees, and other
documents, to the exchange agent by registered mail, return receipt
requested, overnight courier, or hand delivery as follows:

         Continental Stock Transfer & Trust Co., Inc.
         2 Broadway
         New York, NY 10004
         Attn: Compliance Department
         Telephone number: 212-509-4000.

         Delivery to an address and in a manner other than those indicated
above does not constitute good delivery to the exchange agent.

         The method of delivery of the Letter of Transmittal and certificates
to the exchange agent will be at the election and risk of each holder of the
Class A Warrants. The Letters of Transmittal and certificates can be sent to
the exchange agent by hand delivery, courier service, or by mail. If you send
the Letters of Transmittal and certificates by mail, we recommended that you
send them by registered mail with return receipt requested; we also recommend
that you allow a sufficient number of days to ensure that the transmittal and
certificates are delivered to the exchange agent prior to the expiration time.

         All questions concerning the timeliness, validity, form, and
eligibility of submissions will be determined by us, and our determinations
will be final and binding. We, in our sole discretion, may waive any defect or



irregularity, or permit a defect or irregularity to be corrected within such
time as it may determine, or reject any purported submission. Letters of
Transmittal will not be deemed to have been received or accepted until all
irregularities have been waived or cured within such time as we determine in
our sole discretion. Neither we nor the exchange agent will be under any duty
to give notification of any defect or irregularity in connection with the
submission of Letters of Transmittal or incur any liability for failure to
give such notification.


NO WITHDRAWAL RIGHTS

         Any tender of the Class A Warrants to the exchange agent will be
irrevocable. A holder who has submitted his or her Class A Warrants for
exchange may not withdraw them. We have the right, in our sole discretion, to
extend the expiration date of the exchange offer or offer withdrawal rights
on a case-by-case basis in the future.


CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE EXCHANGE

         The exchange of Class A Warrants for Class B Warrants will be
treated as an "exchange" for federal income tax purposes under the applicable
provisions of the Internal Revenue Code. We do not expect that holders who
exchange their Class A Warrants for Class B Warrants or who receive Class C
Warrants following exercise of their Class A Warrants will recognize any gain
or loss.

         The exchange of Class A Warrants for Class B Warrants will not be a
taxable event to holders of the warrants. After the exchange, a holder's
basis in the Class B Warrants or Class C Warrants received in the exchange
will be the same as the basis the holder had in the securities surrendered in
the exchange.

         The above discussion summarizes the expected tax effects of the
exchange, although there is no definitive guidance on point. The IRS could
disagree with the conclusions reached by us. In the event of such
disagreement, there is no assurance that the IRS would not prevail in a
judicial or administrative proceeding. As a result of the complexity of the
tax laws and the impact of each holder's particular circumstances upon the
tax consequences of the exchange offer, the information set forth above
regarding the federal income tax consequences of the exchange offer is not
intended to be individualized tax or legal advice to holders. Each holder
considering participation in the exchange offer should consult his or her own
tax or financial counsel as to the specific federal, state, and local tax
consequences of the exchange, if any, to such holder.


PARTICIPATION BY DIRECTORS AND OFFICERS IN THE EXCHANGE OFFER

         No directors or officers of Isonics beneficially own any Class A
Warrants.


ISSUANCE OF NEW CERTIFICATES

         Certificates representing Class B Warrants, and in some cases, Class
C Warrants will be delivered to participating holders as soon as practicable.


LOST CERTIFICATES

         If you have lost or misplaced your certificates representing Class A
Warrants, or if they have been destroyed, contact the transfer agent for
additional information on the replacement and exchange of your Class A
Warrants. You may be required to provide an indemnity bond in connection with
the replacement of lost or



destroyed certificates.


REQUESTS FOR ADDITIONAL INFORMATION

         If you have questions or require additional information concerning
the offering, please contact the following person at the address and
telephone number stated below:

                  Brantley J. Halstead
                  Vice President - Finance
                  Isonics Corporation
                  5906 McIntyre Street
                  Golden, CO 80403
                  Telephone No.:  (303) 279-7900
                  Facsimile No.:  (303) 279-7300
                  e-mail:  bhalstead@isonics.com


               PROCEDURE FOR EXERCISE OF THE WARRANTS AND TAX ASPECTS


PROCEDURE TO EXERCISE WARRANTS. The Class A Warrants were distributed to the
public in September 1997, and have been trading on the over-the-counter
market until July 2000. The Class A Warrants have been quoted on the Nasdaq
SmallCap Market since July 2000. As of January 17, 2001, none of the Class A
Warrants have been exchanged for Class B Warrants. On December 13, 2000,
675,000 restricted Class B Warrants were issued. As of January 17, 2001, none
of the Class C Warrants have been issued, however:

         additional unrestricted Class B Warrants, will be issued to any person
         who accepts our Exchange Offer and delivers his or her Class A Warrant
         certificate to our Exchange Agent as described in the preceding
         section; and

         the Class C Warrants, will be issued to any person who exercises a
         Class A Warrant or a Class B Warrant before the following dates: April
         30, 2001 with respect to the Class A Warrants, and December 31, 2005
         with respect to the Class B Warrants.

         Each registered holder of a Class A Warrant should have possession
of a certificate that represents that Class A Warrant. Persons who hold their
Class A Warrants in a brokerage account or otherwise in a "street name"
account may ask their brokers to deliver a Class A Warrant certificate to
them. Certificates will be issued to persons entitled to receive Class B
Warrants or Class C Warrants unless a person exchanging his or her Class A
Warrant chooses to exercise the Class B Warrant simultaneously.

REGISTERED HOLDERS. If you are a registered holder, and if you have
possession of your Class A Warrant certificate, in order to exercise a Class
A Warrant, you must:

         o    complete the subscription form which is included as a part of
              the Class A Warrant Certificate;

         o    sign the subscription form and have your signature medallion
              guaranteed by a broker-dealer member of the STAMP program;

         o    deliver the original warrant certificate with the completed,
              signed, and medallion guaranteed subscription form to
              Continental Stock Transfer & Trust Co., Inc., 2 Broadway,
              New York, NY



              10004, Attn: Compliance Department; and

         o    include your payment for the exercise price ($5.80 times the
              number of warrants being exercised for the Class A Warrants,
              $1.50 times the number of warrants being exercised for the
              Class B Warrants; and $2.50 times the number of warrants being
              exercised for the Class C Warrants). You must pay for the
              exercise by certified or bank cashiers' check payable in
              United States funds to the order of Isonics Corporation. If
              you prefer to wire transfer funds, you should contact
              Continental Stock Transfer & Trust Company by telephone and
              request wiring instructions. Continental Stock Transfer can be
              reached by telephone at (212)-509-4000.

         We recommend that you do not send your warrant certificate or funds
through the regular U.S. Mail. We recommend that you use registered or
certified U.S. Mail, or a courier service that will provide you a receipt
indicating that Continental Stock Transfer received your warrant certificate
and payment. Neither we, nor Continental Stock Transfer, are responsible for
your warrant certificate or your payment until Continental Stock Transfer
actually receives delivery. DO NOT SEND WARRANT CERTIFICATES OR PAYMENT
DIRECTLY TO ISONICS CORPORATION.

WARRANTS HELD IN A BROKERAGE ACCOUNT OR OTHERWISE IN STREET-NAME. If you hold
your Class A Warrants, Class B Warrants, or Class C Warrants in a brokerage
account or otherwise in a "street name" account, you must follow the
procedures required by your broker, dealer, or other street-name holder.

LOST WARRANT CERTIFICATES. If you have lost your Warrant certificate, you
must contact Continental Stock Transfer & Trust Co., Inc., and follow the
procedures established by Continental Stock Transfer for your lost Warrant
certificate. If you have lost your certificate, please ensure that you leave
a sufficient amount of time before expiration of your Class A Warrant, or
expiration of the Exchange Offer, to follow the lost instrument procedures.

TAX ASPECTS. No gain or loss will be recognized by a holder of either the
Class B Warrant or the Class C Warrant held for investment on the holder's
purchase of Common Stock for cash upon exercise of the Warrant. The adjusted
tax basis of the Common Stock so acquired will be equal to the tax basis of
the Warrant plus the exercise price. The holding period of the Common Stock
acquired upon the exercise of the Class B Warrant, or the Class C Warrant,
will begin on the date the Warrant is exercised and the Common Stock is
purchased.


                               USE OF PROCEEDS

         Isonics will not receive any cash proceeds from the exchange of the
Class A Warrants, or the issuance of the Class B Warrants.

         Isonics will receive from $0.00 to a maximum of $1,215,000, from the
exercise of the Class B Warrants issuable upon exchange of the Class A
Warrants (not including any securities issuable upon exercise of the
Underwriters' Warrants). We expect to use any proceeds received for research
and development and working capital. We do not believe that it is in the best
interests of any person holding a Class A Warrant to exercise that Class A
Warrant; we believe that each person holding a Class A Warrant would be
better served by exchanging their Class A Warrant for a Class B Warrant.

         If all of the Class A Warrants are exchanged and all of the Class B
Warrants are exercised before December 31 2005, (of which we can offer no
assurance), there will be 1,485,000 Class C Warrants outstanding. We will
receive from $0.00 to a maximum of $3,712,500.00 from the exercise of the
Class C Warrants. (The foregoing discussion does not include any Warrants
that may be issued upon exercise of the Underwriters' Warrants.) We expect to
use any proceeds received for research and development and working capital.



                      MANAGEMENT'S DISCUSSION AND ANALYSIS
                   OF FINANCIAL CONDITION OR PLAN OF OPERATION

         THE STATEMENTS CONTAINED IN THIS PROSPECTUS THAT ARE NOT PURELY
HISTORICAL ARE FORWARD-LOOKING STATEMENTS. "FORWARD LOOKING STATEMENTS"
INCLUDE STATEMENTS REGARDING OUR EXPECTATIONS, HOPES, INTENTIONS, OR
STRATEGIES REGARDING THE FUTURE. FORWARD LOOKING STATEMENTS INCLUDE:
STATEMENTS REGARDING FUTURE PRODUCTS OR PRODUCT DEVELOPMENT; STATEMENTS
REGARDING FUTURE SELLING, GENERAL AND ADMINISTRATIVE COSTS AND RESEARCH AND
DEVELOPMENT SPENDING, AND OUR PRODUCT DEVELOPMENT STRATEGY; STATEMENTS
REGARDING FUTURE CAPITAL EXPENDITURES AND FINANCING REQUIREMENTS; AND SIMILAR
FORWARD LOOKING STATEMENTS. ALL FORWARD-LOOKING STATEMENTS INCLUDED IN THIS
DOCUMENT ARE BASED ON INFORMATION AVAILABLE TO US ON THE DATE HEREOF, AND WE
UNDERTAKE NO OBLIGATION TO UPDATE ANY SUCH FORWARD-LOOKING STATEMENTS. IT IS
IMPORTANT TO NOTE THAT OUR ACTUAL RESULTS COULD DIFFER MATERIALLY FROM THOSE
IN SUCH FORWARD-LOOKING STATEMENTS.


OVERVIEW

         Founded in 1992, Isonics Corporation ("Isonics" or the "Company") is
a specialty chemical and advanced materials company, which develops and
commercializes products based on enriched stable isotopes. Enriched stable
isotopes are ultra pure materials engineered at the molecular level to
provide enhanced performance properties in semiconductors, lasers and high
performance lighting and energy production. Enriched stable isotopes are also
widely used in basic research, pharmaceutical development and drug design, as
well as in medical diagnostics and imaging. By replacing materials
traditionally used in these industries with isotopically engineered versions
of the same materials, product performance, safety, and economics can be
enhanced significantly. Using state-of-the-art technology, we produce a wide
range of enriched stable isotopes, which are then converted into products,
which meet the specialized needs of our customers.

         Originally, our core business was the production and supply of
depleted zinc, a non-radioactive stable isotope, to the energy industry. In
fiscal 1996, we expanded our business scope to include development of
isotopically engineered materials for the medical research, medical
diagnostic and semiconductor industries. The acquisition of Chemotrade GmbH
("Chemotrade") in 1998 added radioactive isotopes (or radioisotopes) to our
available products. As a result of the sale of our depleted zinc business in
December 1999, (as described in the paragraph entitled "SALE OF DEPLETED ZINC
BUSINESS,") our revenues in the future will depend on our success in
developing and selling products in the semiconductor and stable and
radioactive isotope markets.

         On May 1, 2000, we reorganized International Process Research
Corporation ("Interpro," doing business as Colorado Minerals Research
Institute), as described in the paragraph, "REORGANIZATION OF INTERPRO
SUBSIDIARY." Previously Interpro was a contract research and development and
materials processing company and was developing new, lower cost technologies
to better meet our then existing customers' needs. As a result of the
reorganization, Interpro will focus on one specific application-the recovery
and recycling of zinc metal from various sources. As discussed below, we have
entered into a letter of intent to sell all of Interpro to a management
group, although this transaction is subject to definitive agreements that
have not yet been negotiated, as well as other considerations.

         Chemotrade is headquartered in Dusseldorf, Germany, and its
subsidiary is located in Leipzig, Germany. Chemotrade is a value-added
re-seller of stable and radioactive isotopes. It supplies radioactive
isotopes for pharmaceutical and industrial research as well as for industrial
and medical imaging, calibration sources and for brachytherapy applications.

         Additionally, Chemotrade supplies various stable isotope labeled
compounds for pharmaceutical research and drug design, as well as oxygen-18
for use in producing a radioisotope used in positron emission tomography.
Chemotrade's market is primarily Europe but sales are also made to North
America and Asia.

         Prior to June 1998, substantially all of our net revenues in any
particular period were attributable to a



limited number of customers and sales of depleted zinc and other stable
isotopes. We have historically operated with little backlog. With the
acquisition of Chemotrade we added radioisotopes to our product mix, and
consistent with our historical experience, our quarterly results have been
materially affected by the size, timing and quantity of orders and product
shipments during a given quarter.


SALE OF DEPLETED ZINC BUSINESS

         On December 1, 1999, we sold our depleted zinc business to
Eagle-Picher Technologies, LLC ("Eagle-Picher") for approximately $8.2
million, of which $6.7 million was paid on December 1, 1999. Subject to
certain conditions three additional annual payments of $500,000 each are due
on November 30, 2000, 2001 and 2002, representing the balance of $1.5
million. These installments are contingent upon the performance of an
unaffiliated supplier of depleted zinc whose contract with us was assigned to
Eagle-Picher.

         Eagle-Picher failed to make the first additional payment due
November 30, 2000. We believe that the condition precedent has been met and
that Eagle-Picher has no defense to its non-payment. We have demanded payment
from Eagle-Picher, but Eagle-Picher has made an unacceptable counteroffer.
Correspondence from Eagle-Picher indicated that it may be using the mandatory
payment as leverage to renegotiate certain other portions of our agreements.

         We had intended to recognize a contingent gain, of $1.5 million, on
a straight-line basis over the thirty-six month period (approximately $41,667
per month), as the aforementioned unaffiliated supplier performed under the
contract. Three months, or approximately $125,000, have been recognized in
the quarter ended October 31, 2000. Approximately $250,000 has been
recognized in the six months ended October 31, 2000. We will cease
recognizing any additional contingent gain until the dispute with
Eagle-Picher has been resolved. We have not yet established a reserve for the
$500,000 due on November 30, 2000, as we believe we will be able to resolve
this dispute and collect the $500,000. If, however, the matter is not
resolved by January 31, 2001, we will incur a charge of $500,000 to offset
the contingent gain recognized since December 1999.

         Additionally, we signed a long-term isotope supply agreement with
Eagle-Picher, and Eagle-Picher was to have supplied us by December 31, 2000,
with 200 kilograms of silicon-28 to be used in research and development
activities. We gave Eagle-Picher a warrant to obtain 4,000,000 shares of our
common stock, however, these warrants and the underlying shares, are
contingent upon the delivery of silicon-28 by Eagle-Picher by December 31,
2000. As silicon-28 was to be delivered we intended to record the value of
the silicon and the warrants proportionately (20,000 warrants per kilogram),
at a value of $25.00 per gram. This is the price we most recently paid for
silicon-28 from another supplier.

         In addition to its refusal to pay the aforementioned $500,000 due
November 30, 2000, Eagle-Picher failed to deliver any portion of the required
200 kilograms of silicon-28. We know that Eagle-Picher's silicon-28
production facility in Oklahoma has encountered certain technical
difficulties, which Eagle-Picher refers to as a FORCE MAJEURE. We believe
that Eagle-Picher's technical difficulties do not meet the definition of
FORCE MAJEURE set forth in our agreements and that there is no contractual
excuse for its failure to meet its delivery requirement.

         Eagle-Picher exercised their warrant, under a net exercise provision
in the warrant agreement, and received 3,130,435 shares of our Common Stock,
in March 2000. Eagle-Picher disputes our calculation and believes we should
issue to it an additional 155,279 shares of Common Stock. We believe
Eagle-Picher's calculation is in error. As Eagle-Picher is claiming FORCE
MAJEURE, it believes it is entitled to retain its ownership to the 3,130,435
shares, as well as the disputed 155,279 shares of our Common Stock. We
continue to dispute Eagle-Picher's calculations, and we also believe
Eagle-Picher may have improperly exercised the Warrant because of its failure
to execute the required subscription agreement. We are evaluating the
ramifications of this



apparent improper warrant exercise. We have also advised Eagle-Picher that we
intend to cancel the shares issued to it as partial satisfaction of the
damages that we have suffered as a result of Eagle-Picher's non-performance.

         Isonics and Eagle-Picher have commenced efforts to resolve these and
other disputes relating to its contract, but there has been no satisfactory
resolution to date.

         As a result of Eagle-Picher's alleged breaches and defaults, we did
not receive the 200 kilograms of silicon-28 meeting the specifications set
forth in the agreement, as promised by Eagle-Picher. We have other sources of
supply for silicon-28 meeting the necessary specifications, although orders
have not been placed. Without silicon-28 meeting our specifications our
research and development activities will be hindered. Additionally,
Eagle-Picher's failure to make the payment due on November 30, 2000, has
caused our working capital to be significantly reduced, and we are seeking
other means of financing our operations. On December 13, 2000, we entered
into a financing agreement described in more detail in the paragraph titled,
"LIQUIDITY AND CAPITAL RESOURCES."

         As a result of the sale of the depleted zinc business, we have
realized significantly lower revenues in the period since the completion of
the sale, and we anticipate lower revenues in future quarters. Consequently,
a lost or delayed sale of stable or radioisotopes could have a significant
impact on our operating results for a particular period, and any fluctuations
could materially and adversely affect our business, financial condition and
results of operations.


REORGANIZATION OF INTERPRO SUBSIDIARY

         On May 1, 2000, we substantially reorganized one of our
subsidiaries, Interpro, to focus on one specific application, the recovery
and recycling of zinc metal from various sources, including galvanized steel
scrap, electric arc furnace dust, and brass scrap. We chose this course of
action for two reasons. First, we believe the market potential for this, and
related processes, is significant. Second, the profound and lengthy slump in
the mineral processing and mining industries has significantly eroded
Interpro's historical customer base. We will continue to meet the demands of
a few remaining customers through various sub-contractor relationships. We
will also keep the physical infrastructure in place at our Golden, Colorado
location if market conditions warrant a reentry into Interpro's historical
markets. Currently, we are using a significant portion of this infrastructure
in our zinc recovery and recycling project.

         We are presently considering alternatives for Interpro, and the zinc
recovery business, because of its significant negative cash flow and the
failure to attract any outside investors. Management estimates the negative
cash flow directly attributable to the zinc recovery project to be
approximately $100,000 per month. It is also Management's opinion that
outside investors are reluctant to invest in the zinc recovery business as
long as it is part of Isonics. As a result, we have entered into a letter of
intent for the sale of Interpro a management group that will assume the
related assets, liabilities, and all subsequent expenses and costs of
developing the zinc recovery business. The Board of Directors has received
such an offer subject to the finalization of acceptable terms, the
preparation of a "fairness opinion," and the possible submission of the
matter to, and approval by, our shareholders.

         In the quarter ended October 31, 2000, we recognized a $270,000
expense to remediate the Golden, Colorado facility we currently lease. This
expense will be incurred prior to the expiration of our lease in June 2001.
In the event that the zinc recovery business is sold, this would become the
obligation of the management group proposing to buy the zinc recovery
business. A condition of the transaction is that they obtain an extension of
this lease, which would extend the environmental remediation obligation.




RESULTS OF OPERATIONS

         The following table sets forth, for the periods indicated, certain
statement of operations data expressed as a percentage of net sales. The
table and the discussion below should be read in conjunction with the
condensed consolidated financial statements and the notes thereto appearing
elsewhere in this report.



                                                Three Months Ended                          Six Months Ended
                                                    October 31,                                October 31
                                       --------------------------------------     --------------------------------------
                                              2000                 1999                 2000                 1999
                                       ----------------      ----------------     ---------------       ----------------
                                                                                            
Net revenues                                 100.0    %           100.0    %           100.0    %           100.0    %
Cost of revenues                              79.3                 77.8                 77.0                 77.8
                                       ----------------      ----------------     ---------------       ----------------
     Gross margin                             20.7                 22.2                 23.0                 22.2
                                       ----------------      ----------------     ---------------       ----------------
Operating expenses:
     Selling, general &
          Administrative                      91.0                 21.2                 74.7                 24.3
     Research & development                   21.1                  4.6                 17.9                  4.4
     Restructuring & office closure             --                   --                   --                  0.8
                                       ----------------      ----------------     ---------------       ----------------
          Total operating expenses           112.1                 25.8                 92.6                 29.5
                                       ----------------      ----------------     ---------------       ----------------
Operating income (loss)                     (91.4)                (3.6)               (69.6)                (7.3)
                                       ----------------      ----------------     ---------------       ----------------

Other income (expense) net                     2.1                  0.4                  4.9                (0.9)
                                       ----------------      ----------------     ---------------       ----------------
Income (loss) before income taxes           (89.3)                (3.2)               (64.7)                (8.2)
                                       ----------------      ----------------     ---------------       ----------------
Income tax expense (benefit)                 (0.1)                   --                   --                   --
                                       ----------------      ----------------     ---------------       ----------------
NET INCOME (LOSS)                           (89.2)    %           (3.2)    %          (64.7)    %           (8.2)    %
                                       ================      ================     ===============       ================




                                                 Twelve Months Ended
                                                      April 30,
                                       --------------------------------------
                                              2000                 1999
                                       ----------------      ----------------
                                                       
Net revenues                                 100.0    %           100.0    %
Cost of revenues                              79.8                 78.7
                                       ----------------      ----------------
     Gross margin                             20.2                 21.3
                                       ----------------      ----------------
Operating expenses:
     Selling, general &
          Administrative                      29.1                 21.4
     Research & development                    9.6                  6.8
     Restructuring & office closure            0.4                  4.1
                                       ----------------      ----------------
          Total operating expenses            39.1                 32.3
                                       ----------------      ----------------
Operating income (loss)                     (18.9)               (11.0)
                                       ----------------      ----------------



Other income (expense) net                    41.0                (2.8)
                                       ----------------      ----------------
Income (loss) before income taxes             22.1               (13.8)
                                       ----------------      ----------------
Income tax expense (benefit)                   1.0                  1.0
                                       ----------------      ----------------
NET INCOME (LOSS)                             21.1    %          (14.8)    %
                                       ================      ================



NET REVENUES

         Net revenues for the three months ended October 31, 2000, were
$1.955 million, a decrease of approximately 56%, or $2.505 million, from
$4.460 million for the same period in the prior fiscal year. The decrease is
primarily because our net revenues from isotope product sales decreased
approximately $2.121 million for the three months ended October 31, 2000, to
approximately $1.955 million. This reduction is due to the lack of depleted
zinc revenues after the sale of the depleted zinc business to Eagle-Picher,
and the recent acquisition of a major customer by one of our competitors. Net
revenues from contract research and development services sales decreased
approximately $384,000 for the three months ended October 31, 2000, to $0,
because of our cessation of these activities at our subsidiary Interpro.

         Net revenues for the six months ended October 31, 2000, were $3.991
million, a decrease of approximately 47%, from $7.544 million for the same
period in the prior fiscal year. This reduction is due to the lack of
depleted zinc revenues after the sale of the depleted zinc business to
Eagle-Picher, and the recent acquisition of a major customer by one of our
competitors. Net revenues from contract research and development services
sales decreased approximately $717,000 for the six months ended October 31,
2000, to $0, because of our cessation of these activities at our subsidiary
Interpro.

         Following the end of our fiscal quarter, we were adversely impacted
by one customer's failure to pay approximately $218,000 in invoices due.
Additionally, we had ordered, based on purchase orders placed by this
customer, approximately $131,000 in product from our suppliers. We have taken
the actions we believe appropriate to recover these obligations. We have been
informed by the management of this customer that they are currently selling a
portion of their business and intend to pay the amounts owed us with the
proceeds from this sale. We believe if this customer does not honor its
purchase orders we will be able to sell the inventory to other customers.

         We do not anticipate significant revenues from sales of silicon-28
based products in the fiscal year ended April 30, 2001, and our ability to
achieve any revenues from silicon-28 based products is dependent on
continuing research and development, and our ability to obtain an adequate
supply of silicon-28 from Eagle-Picher or other suppliers. We are
collaborating with academia and industry to evaluate the benefits of
isotopically pure silicon-28. We believe that if evaluations demonstrate the
commercial feasibility of one or more products, demand could emerge in
certain segments of the semiconductor market. We can offer no assurance,
however, that these evaluations will demonstrate the commercial feasibility
of any products, that we will be able to commercialize any such products, or
that a market will emerge for any such products.

         We are engaging in research and development to diversify our
business and to expand other lines of our business. We have also expanded our
sales and marketing efforts. We are now seeking to identify and evaluate a
variety of new stable isotope products and potential markets for economic and
technical feasibility. We will continue to fund research and development to
improve technologies for isotope separation and materials processing
technologies. During fiscal 2000, 1999, and 1998, research and development
expenses were $1,224,000, $1,155,000, and $811,000, respectively. We cannot
offer any assurance that our current or future lines of business and our
research and development efforts will be profitable or generate significant
revenues.




         Net revenues decreased from $16,998,000 in fiscal 1999 to $12,733,000
in fiscal 2000, a decrease of $4,265,000 or 25.1%. The decrease is primarily
because of the sale of our depleted zinc business to Eagle-Picher in December
1999, and reduced revenue from our contract research and process development
operations. Depleted zinc revenues in fiscal 2000 were $2,645,000, as compared
to fiscal 1999 revenues of $5,959,000, a decrease of $3,314,000, or 55.6%. This
decrease is attributable to only having approximately seven months of sales in
fiscal 2000, because of the Eagle-Picher transaction, versus twelve months of
sales in fiscal 1999. Interpro's fiscal 2000 revenues were $1,156,000, as
compared to fiscal 1999 revenues of $2,614,000, a decrease of $1,458,000, or
55.8%. We will have no revenues from depleted zinc or Interpro in fiscal 2001,
because: we have sold our depleted zinc business; and have ceased
revenue-generating operations at our Interpro subsidiary to focus Interpro's
resources exclusively on developing a zinc recovery and recycling technology.
Both the depleted zinc sale and the zinc recovery and recycling process project
are described above. See "SALE OF DEPLETED ZINC BUSINESS, AND REORGANIZATION OF
INTERPRO SUBSIDIARY."

         International sales represented approximately 65% of revenues in fiscal
2000, and 60% of revenues in fiscal 1999. This increase is primarily
attributable to significantly lower domestic revenues from Interpro, which were
partially offset by increased domestic sales of stable isotopes (excluding
depleted zinc). Lower depleted zinc sales had a comparable effect on both
international and domestic sales.


GROSS MARGIN

         As a result of the sale of the depleted zinc business to Eagle-Picher
on December 1, 1999, we anticipate gross margin will be decreased on an annual
basis by approximately $1.0 million dollars.

         Gross margin for the three months ended October 31, 2000, decreased to
approximately 20.7% of net revenues from approximately 22.2% for the same period
in the prior fiscal year. The decrease is primarily because of the lack of
depleted zinc sales and sales to a lost customer that carried higher margins.
Gross margin for the six months ended October 31, 2000, increased to
approximately 23.0% of net revenues from approximately 22.2% for the same period
in the prior fiscal year.

         Gross margin decreased approximately $1,046,000, to approximately
$2,577,000, in fiscal 2000, from approximately $3,623,000, in fiscal 1999. On a
percentage of net revenues basis gross margin decreased 1.1 percentage points to
approximately 20.2% in fiscal 2000, from approximately 21.3% in fiscal 1999. The
dollar and percentage point decreases are primarily because of reduced sales of
depleted zinc, typically a higher margin product, and an increase in stable and
radioisotope revenues generated by both Isonics and Chemotrade. In general,
stable isotopes typically have lower margins because of more sales competition.


SELLING, GENERAL, AND ADMINISTRATIVE EXPENSES

         We anticipate that our selling, general, and administrative expenses
will increase during the current fiscal year as we increase our sales and
marketing efforts in other product lines. As a percentage of revenues selling,
general and administrative expenses should increase, as revenues (current fiscal
year quarter to prior fiscal year quarter) will be significantly lower.

         Selling, general, and administrative expenses increased on a dollar
basis to approximately $1.780 million, or approximately 91.0% of net revenues
for the three months ended October 31, 1999, from $945,000, or 21.2% of net
revenues in the comparable period of the prior year. The dollar increase for the
quarter ended October 31, 2000, was primarily attributable to increased usage of
professional services including legal, business development and accounting
services, bad debt expense (as described above in the paragraph titled "NET
REVENUES"), and remediation expenses related to our Golden facility, while the
percentage increase was



primarily caused by lower revenues as described above, as well as, higher
levels of spending.

       In the quarter ended October 31, 2000, we recognized a $270,000 expense
to remediate the Golden, Colorado facility we currently lease. This expense will
be incurred prior to the expiration of our lease in June 2001. If we are able to
sell the zinc recovery business, we anticipate that this would become the
obligation of the management group proposing to buy the zinc recovery business.

         Selling, general and administrative expenses increased on a dollar
basis to approximately $2,980,000, or approximately 74.7% of net revenues for
the six months ended October 31, 2000, from approximately $1,830,000 million, or
approximately 24.3% of net revenues for the six months ended October 31, 1999.
The dollar increase for the six months ended October 31, 2000, is primarily
attributable to increased usage of professional services including legal,
business development and accounting services, bad debt expense, and remediation
expenses related to our Golden facility, while the percentage increase was
primarily caused by lower revenues as described above, as well as, higher levels
of spending.

         Selling, general, and administrative expenses increased on a dollar
basis by approximately $55,000 to $3,698,000, in fiscal 2000 from $3,643,000 in
fiscal 1999. Selling, general, and administrative expenses increased on a
percentage of net revenues basis by 7.6 percentage points to 29.1% of net
revenues in fiscal 2000, from 21.4% of net revenue in fiscal 1999. The dollar
increase in selling, general and administrative expenses is primarily
attributable to increased compensation expense and professional service fees at
the corporate level. The percentage of net revenues increase is primarily
attributable to lower net revenues ($12,733,000 in fiscal 2000, and $16,998,000
in fiscal 1999). See "LIQUIDITY AND CAPITAL RESOURCES" and "BUSINESS THAT WE
SOLD."

         We expect that our selling, general and administrative expenses will
continue to fluctuate as we are attempting to develop and market new products
and increase the sales of our existing products. While we are attempting to keep
control over these expenses, we anticipate that we will not be able to reduce
selling, general, and administrative expenses in the near future. Our goal is to
increase revenues so that selling, general, and administrative expenses as a
percentage of revenues will decrease over time.


RESEARCH AND DEVELOPMENT

         Research and development expenses increased by approximately $207,000,
or approximately 101%, to $412,000, for the quarter ended October 31, 2000, from
$205,000 for the comparable period in fiscal 1999, while increasing on a
percentage basis to approximately 21.1% of net revenues from approximately 4.6%.
The dollar increase during the quarter ended October 31, 2000, was primarily
because of research and development costs associated with the development of our
zinc recovery and recycling project. The percentage increase is primarily
attributable to lower revenues as described above, as well as, higher levels of
spending.

         Research and development expenses increased by approximately $384,000,
or approximately 116%, to $716,000 for the six months ended October 31, 1999,
from $332,000 for the comparable period in fiscal 1999, while increasing on a
percentage basis to approximately 17.9% of net revenues from approximately 4.4%.
The dollar increase during the six months ended October 31, 2000, was primarily
because of research and development costs associated with the development of our
zinc recovery and recycling project. The percentage increase is primarily
attributable to lower revenues as described above, as well as, higher levels of
spending.

         Research and development expenses increased on a dollar basis by
approximately $69,000 to $1,224,000, in fiscal 2000 from $1,155,000 in fiscal
1999. Research and development expenses increased on a percentage of net
revenues basis by 2.8 percentage points to 9.6% of net revenues in fiscal 2000
from 6.8% of net revenue in fiscal 1999.



         As described above in the paragraph titled "SALE OF DEPLETED ZINC
BUSINESS," we signed a long-term isotope supply agreement with Eagle-Picher,
under which Eagle-Picher will supply us with 200 kilograms of silicon-28 in
2000. The silicon-28 will be used to further development of our semiconductor
materials business. We also gave Eagle-Picher a warrant to obtain 4,000,000
shares of our common stock. The warrants are contingent upon the delivery of
silicon-28 by Eagle-Picher. The anticipated value of the 200 kilograms is
approximately $5,000,000. As we use the silicon-28 in our research and
development activities, we will recognize an expense of approximately $25.00 per
gram, as this is the price we most recently paid for silicon-28 from another
supplier.

         As also described above Eagle-Picher did not meet this obligation to
deliver the 200 kilograms of silicon-28 for which we have already paid
Eagle-Picher. We have held several discussions with Eagle-Picher regarding this
and other Eagle-Picher failures, which we believe, have occurred under our
agreements. If we are able to reach a resolution with Eagle-Picher, they may
still deliver the required silicon-28 to us in the future; if we are not able to
reach any agreement with Eagle-Picher, they may not deliver any silicon-28 to
us. If Eagle-Picher's delay in delivering the silicon-28 is significant, or if
Eagle-Picher's technology cannot produce silicon-28 meeting our requirements, we
will need to make other arrangements for our silicon-28 supply. These other
arrangements will likely delay our ability to complete our research and
development programs.

         We believe that the development and introduction of new product
applications is critical to our future success and we expect that research and
development expenses will increase (as measured in dollars), in the near term
because of the timing of material usage and outside services, but will likely
continue to vary as a percentage of revenues because of the timing and amount of
future revenues.

         On May 1, 2000, we substantially reorganized Interpro to focus on one
specific application, the recovery and recycling of zinc metal from various
sources including, galvanized steel scrap, electric arc furnace dust, and brass
scrap. We chose this course of action for two reasons. First, we believe the
market potential for this, and related processes, is significant. Second, the
profound and lengthy slump in the mineral processing and mining industries has
significantly eroded Interpro's historical customer base. We will continue to
meet the demands of a few remaining customers through various sub-contractor
relationships. We will also keep the physical infrastructure in place at our
Golden location if market conditions warrant a reentry into Interpro's
historical markets. Currently, we are using a significant portion of this
infrastructure in our zinc recovery and recycling project.

   As discussed above in the paragraph titled, "REORGANIZATION OF INTERPRO
SUBSIDIARY," we are presently considering alternatives for Interpro, and the
zinc recovery business, because of its significant negative cash flow and the
failure to attract any outside investors. Management estimates the negative cash
flow directly attributable to the zinc recovery project to be approximately
$100,000 per month. It is also Management's opinion that outside investors are
reluctant to invest in the zinc recovery business as long as it is part of
Isonics.

         These alternatives include selling a portion or all of the zinc
recovery business to a management group that will assume the related assets,
liabilities, and all subsequent expenses and costs of developing the zinc
recovery business. The Board of Directors has received such an offer subject to
the finalization of acceptable terms, the preparation of a "fairness opinion",
and the possible submission of the matter to, and approval by, our Shareholders.
In the event that the zinc recovery business is sold, we will reduce our
research and development expenses by $75,000 to $100,000 per month.


RESTRUCTURING AND OFFICE CLOSURE

         On October 31, 1998, we announced a restructuring of our operations and
relocation of our headquarters to Golden, Colorado, the location of our
subsidiary, Interpro. We recorded a $691,000 charge in connection with the



restructuring.

         As of October 31, 2000, the only significant restructuring cost
remaining is the lease payments on the former San Jose, California office, which
has been sublet for the remaining term of our lease. The net liability is
estimated to be approximately $40,000, and will be paid over the next four
years. The expense in fiscal 2000, was primarily related to moving costs
incurred by two senior executives.


OTHER INCOME (EXPENSE), NET

         Other income (expense), net includes interest expense, amortization of
debt issuance costs and the fair value of warrants issued in connection with the
debt, and foreign currency gains and losses. Other income (expense), net
increased by approximately $26,000, to $42,000, for the quarter ended October
31, 2000, from other income, net of approximately $16,000, for the comparable
period of the previous fiscal year. The decrease in interest expense of
approximately $91,000 was offset by an increase in foreign currency losses of
$53,000 and a decrease in other income of approximately $12,000.

         Other income, net increased by approximately $256,000, to $193,000, for
the six months ended October 31, 2000, from other (expense), net of
approximately $63,000, for the comparable period of the previous fiscal year.
The decrease in interest expense of approximately $199,000 was augmented by an
increase in other income of approximately $45,000, and a foreign currency
exchange gain of approximately $12,000.

         As described above, Eagle-Picher failed to make the first additional
payment due November 30, 2000. We had intended to recognize a contingent gain,
of $1.5 million, on a straight-line basis over the thirty-six month period
(approximately $41,667 per month), as the aforementioned unaffiliated supplier
performed under the contract. Three months, or approximately $125,000, have been
recognized in the quarter ended October 31, 2000. Six months, or approximately
$250,000, have been recognized in the six months ended October 31, 2000.

         We will cease recognizing any additional contingent gain until the
dispute with Eagle-Picher has been resolved. We have not yet established a
reserve for the $500,000 due on November 30, 2000, as we believe we will be able
to resolve this dispute and collect the $500,000. If, however, the matter is not
resolved by January 31, 2000, we will incur a charge of $500,000 to offset the
contingent gain recognized since December 1999.

         Excluding gain on the sale of the depleted zinc line of business of
approximately $5,296,000, Other income (expense), net, in fiscal 2000 was
approximately ($77,000) a decrease in expense of approximately $407,000 from
($484,000) in fiscal 1999. The decrease in expense is primarily attributable to
lower interest expense (net of interest income) at the corporate level, as there
were no significant borrowings after November 1999, a period of five months.
Also in fiscal 2000, we recognized a gain of $110,000 resulting from the
favorable settlement of a dispute with a vendor.


INCOME TAXES

         We currently operate at a loss and expect to operate at a loss until
the products currently under development begin to generate sufficient revenue.
While we recognized a taxable gain upon the sale of our depleted zinc product
line, the tax expense incurred was offset by the expected recovery of such taxes
due to the availability of net operating losses to offset the taxes paid. As a
result, for the fiscal year ended April 30, 2000, our reported tax expense was
limited to the taxes payable in Germany on the income of our Chemotrade
subsidiary, and state income taxes for which no loss carryforwards were
available.

         The consolidated entity had income tax expense of $129,000 for fiscal
year 2000, and income tax expense



of $171,000 for fiscal year 1999. The income tax expense in fiscal year 2000
is related to the sale of the depleted zinc business. The income tax expense
in fiscal year 1999 resulted from our Chemotrade subsidiary, which had net
income in fiscal year 1999, and paid income taxes in Germany. However, both
United States-based entities had net losses, in fiscal year 1999, and did not
have income tax expense.

         The losses to be incurred in the current year are not expected to
generate an income tax benefit because of the uncertainty of the realization of
the deferred tax asset. As such we have provided a valuation allowance against
the deferred tax assets for the amount in excess of the taxes paid in prior
years that are subject to refund.


NET INCOME (LOSS)

         We recognized net losses of $2,583,000 and $616,000, for the six months
ended October 31, 2000 and 1999, respectively. We recognized net losses of
$1,744,000 and $143,000, for the quarters ended October 31, 2000 and 1999,
respectively. Losses of this magnitude will likely continue until revenues
increase from our current operations or research and development projects.

         We recognized net income of $2,689,000 for the fiscal year ended April
30, 2000, as compared to a net loss of $2,521,000 for the fiscal year ended
April 30, 1999. Net income in fiscal 2000 was primarily because of the gain of
$5,296,000 on the sale of our depleted zinc business to Eagle-Picher in December
1999, a transaction that will not recur. Without that one-time gain, we would
likely have recognized a net loss.

         Net income in future years will be dependent on our ability to increase
net revenues while decreasing our selling, general and administrative expenses;
research and development expense; and other expenses as a percentage of net
revenues. Because of our continuing research and development efforts on new
products, we do not expect to generate any significant increase in net revenues
in fiscal 2001, and as a result, anticipate that the current (2001) fiscal
year's operations will result in a significant loss.


LIQUIDITY AND CAPITAL RESOURCES

         Our working capital and liquidity were significantly improved as a
result of the sale of the depleted zinc business to Eagle-Picher on December 1,
1999. However, our liquidity has been decreasing since then and was adversely
affected by a customer failing to pay an account receivable when due, as is
shown by the following table:

      DATE                       WORKING CAPITAL
      ----                       ---------------
January 31, 2000                $4.067 million
April 30, 2000                  $3.754 million
July 31, 2000                   $3.319 million
October 31, 2000                $1.725 million

         We expect that our working capital will continue to decrease over time
as we continue to use our capital for operations, research and development, and
investing activities. We do not expect working capital to increase until, if
ever, we are able to increase our revenues to exceed our cash out-flow. We
cannot offer any assurance that we will be able to do so in the near term. We
believe we have sufficient working capital for the current fiscal year, ending
April 30, 2001, and into the next fiscal year.

         Our principal sources of funding have been cash from sales of lines of
business, borrowed funds, and sales of preferred stock. We used cash in
operating activities of approximately $2.495 million and $1.385



million during the three months ended October 31, 2000, and 1999,
respectively. Cash used in operating activities during the six months ended
October 31, 2000 was principally the result of a net loss of approximately
$2.583 million. Cash used by operating activities during the three months
ended October 31, 1999, was principally the result of a net loss of $1.744
million and increases in accounts receivable, and inventory, offset by
adjustments for non-cash items, primarily depreciation and amortization, and
increases in accounts payable and accrued liabilities.

         Our investing activities used cash of $21,000, and $0 for the three
months ended October 31, 2000, and 1999, respectively, resulting from purchases
of property and equipment.

         Financing activities generated cash of $213,000 and $1.246 million for
the three months ended October 31, 2000, and 1999, respectively. Cash provided
by financing activities during the three months ended October 31, 2000, resulted
primarily from the exercise of employee stock options. Net repayments of debt of
$3,000 were the primary use of cash in financing activities for the six months
ended October 31, 2000. Cash provided by financing activities during the six
months ended October 31, 1999, resulted primarily from the issuance of
convertible preferred stock for cash of $2.250 million and proceeds from the
issuance of long-term debt of $75,000. Net repayments on the revolving line of
credit of $298,000 and repayments of debt of $781,000 were the primary uses of
cash during the six-month period ended October 31, 1999.

         We used cash in operating activities of approximately $4,327,000 during
fiscal 2000. We generated cash in operating activities of approximately $357,000
during fiscal 1999. The primary negative influence on fiscal 2000 cash flow from
operating activities was the gain on the sale of the depleted zinc business of
approximately $5,296,000.

         Significant positive influences on our fiscal 2000 cash flow from
operations included:

         o        net income of approximately $2,689,000;

         o        an increase in taxes payable of $323,000;

         o        non-cash charges for depreciation and amortization expense of
                  $567,000; and

         o        non-cash charges related to debt restructuring of $160,000.

         Other negative influences on our fiscal 2000 cash flow included:

         o        an increase in accounts and notes receivable of $146,000;

         o        an increase in inventories prior to the Eagle-Picher
                  transaction of $1,066,000;

         o        an increase in prepaid expenses and other assets of $139,000;

         o        a deferred tax benefit of $640,000;

         o        a decrease in accounts payable of $522,000; and

         o        a decrease in accrued liabilities of $336,000.


         Financing activities provided cash of $545,000 in fiscal 2000, and used
cash of $244,000 in fiscal 1999. In fiscal 2000, we had proceeds from the
issuance of preferred stock of approximately $2,250,000. We used



approximately $1,931,000 to pay our line of credit and other borrowings. In
fiscal 1999, the primary use of cash was the excess of repayments of debt,
$1,000,000 over proceeds of debt, $717,000.

         Significant positive influences on our fiscal 2001 cash flow from
operations included:

         o        a decrease in accounts receivable of $200,000; and

         o        a decrease in prepaid expenses and other current assets of
                  $119,000;

         o        an increase in accrued liabilities of $153,000.

         o        non-cash charges for bad debt write-offs, and depreciation and
                  amortization expense of $423,000; and


         Other negative influences on our fiscal 2000 and 2001 cash flow
included:

         o        net loss of approximately $2,583,000;

         o        an increase in notes receivable of $250,000;

         o        an increase in income taxes receivable of $426,000;

         o        a decrease in taxes payable of $367,000;


         Factors resulting in our lower fiscal 1999 cash equivalents included
our cash payments for the acquisition of Chemotrade and the losses incurred in
fiscal 1999. During fiscal 1999, we paid the sellers of Chemotrade approximately
$1,686,000 in cash, and had one note for approximately $826,000 outstanding due
to the sellers on April 30, 1999. This note was repaid in fiscal 2000.

         On July 29, 1999, we completed a $2,745,000 private placement financing
to a limited number of accredited investors (including some creditors who
converted debt). We issued 1,830,000 units, each consisting of one share of
Series A Convertible Preferred Stock and one warrant. We received $2,250,000 in
cash proceeds and converted $425,000 of long-term debt in connection with the
private placement. Each share of the Series A Convertible Preferred Stock is
convertible into one share of our Common Stock at a conversion price of $1.50.
The liquidation preference for the Series A Convertible Preferred Stock is
$1.50. Each warrant allows the investor to purchase one share of Isonics Common
Stock for $3.75 through July 29, 2002. We granted certain registration rights to
the holders of the shares of common stock underlying the Class A Convertible
Preferred Stock and the warrants.

         In addition to converting $425,000 of existing debt into equity as part
of the private placement we:

         o        issued 500,000 warrants to purchase shares of our Common Stock
                  to an investment banker as a commission on this placement. The
                  warrants are exercisable at $3.75 per share through July 29,
                  2002;

         o        issued 46,667 units in satisfaction of all current and future
                  obligations under the Isoserve royalty agreement;

         o        extended the payment due date for the remaining balance on the
                  Chemotrade acquisition note to



                  July 2000; and

         o        extended the payment due date for certain unsecured promissory
                  notes to January 2000, which notes have been paid in full.

         On July 24, 1998, we obtained a $3,000,000 asset based credit facility
for our U.S. operations, secured by our U.S. assets, with an unaffiliated
lender. This facility was repaid, in full, in December 1999 with funds made
available by our sale of assets to Eagle-Picher. The proceeds of that facility
were used to repay approximately $537,000 of debt outstanding and $742,000 of
accounts payable. Chemotrade has one unsecured revolving line of credit for
400,000 DM (approximately $186,000), at April 30, 2000, and subsequently.

         At April 30, 1999, and subsequently until December 1, 1999, we were in
default of our borrowing agreements with Coast Business Credit ("Coast"), and on
December 1, 1999, we had approximately $215,000 of outstanding borrowings. We
have used some of the proceeds of the depleted zinc business sale described
above to pay off the Coast borrowings and our relationship with Coast has been
terminated. We believe that our current cash position, attributable to the
proceeds received from the sale of our depleted zinc business and the reduced
levels of debt associated therewith, will be sufficient to fund operations for
more than the next twelve months. However, our long-term capital requirements
will only be met if we are able to generate profits from operations and positive
cash flows, or develop new sources of financing of which there can be no
assurance. We currently have no borrowing agreements in place with any lenders
or similar organizations.

         At October 31, 2000, we had approximately $1.082 million of cash and
cash equivalents, a decrease of approximately $2.303 million, compared to $3.385
million as of April 30, 2000. At October 31, 2000 we has positive working
capital of $1.725 million, a decrease of $2.029 million from April 30, 2000. The
decrease is largely attributable to net loss of $2.583 for the same period.

         During the six months ended October 31, 1999, we issued approximately
$2.745 million in convertible preferred stock. Cash proceeds totaled
approximately $2.250 million and conversion of notes payable and other
obligations to preferred stock totaled approximately $495,000. This convertible
preferred stock placement is described in detail in the Form 8-K we filed on
August 11, 1999.

         Two events, subsequent to the end of the quarter ended October 31,
2000, significantly and adversely impacted our cash position. A customer has not
paid approximately $218,000 in invoices due at the end of the quarter. This
account receivable has been fully reserved as of October 31, 2000. We have taken
actions we believe appropriate to recover this obligation. In addition we have
ordered $131,000 of product based on purchase orders placed by this customer. We
have been informed by the management of this customer that they are currently
selling a portion of their business and intend to pay the amounts owed us with
the proceeds from this sale. We believe if this customer does not honor its
purchase orders we will be able to sell the inventory to other customers.

         The second adverse event subsequent to the end of the quarter was
Eagle-Picher's failure to make the $500,000 annual installment due November 30,
2000. We have not reserved this amount at this time, as we believe we will
collect this amount including accrued interest in the near future. However, if
we have not collected the $500,000 by January 31, 2001, we will incur a charge
of $500,000 to offset the contingent gain recognized since December 1999.

         One event, subsequent to the end of the quarter ended October 31, 2000,
significantly and positively impacted our cash position. In a private placement
with approximately ten accredited investors we sold 337,500 units consisting of
one share of our Common Stock and two Class B Warrants for $675,000 ($2.00 per
unit). This transaction was completed on December 13, 2000.



         If the zinc recovery business is sold, as discussed in the paragraph
titled, "REORGANIZATION OF INTERPRO SUBSIDIARY," we will reduce our cash outflow
by approximately $100,000 per month. We will also eliminate certain current
liabilities totaling between $500,000 and $750,000, which will improve our
working capital position.


                                   BUSINESS

         We are an advanced materials and technology company, which develops and
commercializes products created from materials whose natural isotopic ratios
have been modified. An isotope is one of two or more species (or nuclides) of
the same chemical element, which differ from one another only in the number of
neutrons in the atom's nucleus. The different number of neutrons can create
significantly different nuclear properties; the most well known of these
properties is radioactivity. Radioactive isotopes (or radioisotopes) can be
found in nature; however, most of our radioisotopes are man-made. Stable
isotopes are not radioactive.

         To take advantage of some of these different nuclear properties-and to
create our products-it is usually necessary to increase ("enrich") or decrease
("deplete") the concentration of a particular isotope or isotopes. There are
over 280 naturally occurring stable isotopes of 83 different elements. The
number of isotopes of any given element varies widely. Stable isotopes of a
given element typically do not differ significantly in their chemical behavior.
Stable isotopes of an element differ in mass and diameter, as well as several
nuclear properties, such as cross-section, spin, and magnetic moment.
Differences in these properties can result in substantially different effects,
and some of these different effects have the potential for commercial
application. Isotopes are typically referred to by their atomic mass number,
which essentially is the sum of the number of protons and neutrons in the atom's
nucleus. For example, oxygen-18 has eight protons and ten neutrons in its
nucleus, and silicon-28 has fourteen protons and fourteen neutrons in its
nucleus.

         For example, in ultra chemically pure crystals, grown for electronics
or optical applications, isotopic impurities are the greatest contributor to
crystal disorder because of mass and diameter variations. Eliminating this
disorder by using a single enriched isotope (i.e. an isotopically pure
substance) results in increased thermal conductivity and optical transparency,
and thus in improved product performance. Similarly, enriching or depleting
isotopes based upon their nuclear cross-sections allows materials to be
engineered for applications in the nuclear power industry, for controlled doping
of some semiconductors in the computer industry, and for use as targets to
produce radioisotopes for the life sciences and other industries.

         Another example is labeling or tagging of materials. By varying the
natural abundance of isotopes present in the material, the material acquires its
own unique mass and/or nuclear magnetic signature. This process "tags" the
material, and most importantly, does not change a given material's chemical
properties. Though chemically equivalent, the "tagged" material is discernible
from unlabeled materials through the use of several types of instruments
including mass spectrometers.

         Enriched stable isotopes may be thought of as extremely pure materials.
Not only are they chemically pure, but also consist primarily of only one
isotope depending on the level of enrichment. This extra degree of purification,
accomplished on the sub-atomic level, provides enhanced performance properties
compared to normal (chemical only) purity materials. Depleted isotopes are
typically processed further, and the elimination (or reduction in level) of an
isotope, or isotopes, prevents the creation of undesirable byproducts in these
subsequent processing steps. In some instances the undesirable byproducts are
produced during the intended use of the non-depleted isotope material.

         Stable isotopes have commercial uses in several areas, including:
energy generation; medical research, diagnostics, and drug development; product
tagging and stewardship; semiconductors; and optical materials. We have
successfully developed and commercialized several isotope products and intend to
promote the emergence



and growth of new stable isotope applications. The radioactive isotopes (or
radioisotopes) we produce and sell are typically used in medical diagnostic,
treatment, and therapy applications. In most cases we first produce an
enriched or depleted stable isotope "target," which is then exposed to an
appropriate form of radiation to create a specific radioisotope.

         A key property of a radioisotope is its half-life. The half-life is a
measure of how fast a radioisotope decays into either a stable isotope or
another radioisotope. Since most radioisotopes used in life science applications
have short half-lives, they are rarely found in nature. Therefore these isotopes
have to be made from a target material, usually in a nuclear reactor or a
cyclotron, and usually used immediately. A nuclear reactor or a cyclotron
generates the appropriate form of radiation required to convert the target
material into the desired radioisotope.

         Today our isotope business addresses the material needs of two primary
markets: life sciences (including healthcare) and semiconductor materials. While
we currently are focusing on these two markets, we continually evaluate other
applications for both stable and radioisotopes. We also sell isotopes for use in
basic scientific research and certain specific industrial applications. We
believe our core competency is our ability to identify, develop, source, and
commercialize products and services based on isotopically engineered materials.

         We were formed in March 1992, as a partnership, and were subsequently
incorporated in California in March 1993, as A&R Materials, Inc. In September
1996, we changed our name to Isonics Corporation. Our principal executive
offices are located at 5906 McIntyre Street, Golden, Colorado 80403. Our
telephone number is (303) 279-7900, and our facsimile number is (303) 279-7300.
Our web site is www.isonics.com.


RECENT BUSINESS ACQUISITIONS


INTERNATIONAL PROCESS RESEARCH CORPORATION

         Effective April 30, 1998, we purchased all of the outstanding capital
stock of International Process Research Corporation ("Interpro") from a
previously unaffiliated corporation (Metallurgy International, Inc.). Interpro,
which does business as Colorado Minerals Research Institute, is a materials
processing and contract research and development company. Interpro performed
(through December 1, 1999) key steps in our depleted zinc manufacturing process.
The acquisition was made to assure future availability of this critical
manufacturing technology, and to provide an infrastructure platform for
performing value-added processing of other isotopes. Interpro has also jointly
developed new, lower-cost technologies to enable its historical customers to
better meet the various metallurgical and mineral processing needs of their
customers. In connection with the acquisition, we issued 353,982 shares of our
Common Stock (valued at $708,000) in exchange for all of the outstanding shares
of Interpro. We accounted for the acquisition as a purchase.

         On May 1, 2000, we substantially reorganized Interpro to focus on one
specific application: the recovery and recycling of zinc metal from various
sources including, galvanized steel scrap, electric arc furnace dust, and brass
scrap. We chose this course of action for two reasons. First, we believe the
market potential for this, and related processes, is significant. Second, the
profound and lengthy slump in the mineral processing and mining industries has
significantly eroded Interpro's historical customer base. However, we will
continue to meet the demands of a few remaining customers through various
sub-contractor relationships. We will also keep the physical infrastructure in
place at our Golden location to allow a reentry into Interpro's historical
markets, if market conditions warrant. Currently, we are using a significant
portion of this infrastructure in our zinc recovery and recycling project.

         We are presently considering alternatives for Interpro, and the zinc
recovery business, because of its significant negative cash flow and the failure
to attract any outside investors. Management estimates the



negative cash flow directly attributable to the zinc recovery project to be
approximately $100,000 per month. It is also Management's opinion that
outside investors are reluctant to invest in the zinc recovery business as
long as it is part of Isonics.

         These alternatives include selling a portion or all of the zinc
recovery business to a management group that will assume the related assets,
liabilities, and all subsequent expenses and costs of developing the zinc
recovery business. The Board of Directors has received such an offer subject to
the finalization of acceptable terms, the preparation of a "fairness opinion,"
and the possible submission of the matter to, and approval by, our Shareholders.

         In the quarter ended October 31, 2000, we recognized a $270,000 expense
to remediate the Golden, Colorado facility we currently lease. This expense will
be paid prior to the expiration of our lease in June 2001. In the event that the
zinc recovery business is sold, this would likely become the obligation of the
management group proposing to buy the zinc recovery business.


CHEMOTRADE

         Effective June 1, 1998, we acquired all of the outstanding shares of
Chemotrade GmbH, 75 percent of the outstanding shares of Chemotrade Leipzig GmbH
and six (6) percent of the outstanding shares of IUT (collectively
"Chemotrade"). All three companies are located in Germany. Chemotrade GmbH is
located in Dusseldorf, Chemotrade Leipzig GmbH is located in Leipzig, and IUT is
located in Berlin. Two common shareholders owned all three companies' shares
that we purchased. All three companies continue to be engaged in the
distribution, development, and manufacture, of stable and radioactive isotopes.
We paid the previously unaffiliated former owners of Chemotrade $855,000 in
cash, 357,730 restricted shares of our Common Stock valued at $894,000, and two
interest bearing notes, one for $924,000 which was paid in September 1998, and a
second note for $826,000 which was partially paid in June 1999, and the balance
was paid in December 1999.

         The purchase agreement provides for the selling shareholders to receive
additional consideration in the event pretax earnings of $481,000 (DM 1,000,000)
are achieved for the year ending April 30, 2001. The maximum additional
consideration that can be earned is $241,000 (DM 500,000). Any additional
consideration will be recorded as additional goodwill.

COMPANY STRATEGY

         We believe that our strength is our ability to bring the necessary
resources together to identify, evaluate, develop, engineer, and successfully
commercialize applications for stable and radioactive isotopes, and value-added
products manufactured from these isotopes. This is evidenced by management's
experience (at Isonics and in prior employment) in developing depleted zinc from
what was initially a cost prohibitive concept to a successful commercial
product. The worldwide market for depleted zinc is now one of the largest for a
stable isotope product, exceeding $10 million per year in sales worldwide.

         We believe we have created a product development model that can serve
as a basis for our current and future expansion. To capitalize on the commercial
opportunities that have been identified for stable isotopes, we have adopted a
business strategy designed to maximize the value of our technologies, business
development, and management resources, while attempting to minimize capital
costs. This strategy involves:

         o        focusing on development of high value-added products, which
                  we expect to have a competitive advantage in large or growing
                  markets;

         o        leveraging research and development expenditures through
                  collaborations, government programs,



                  and corporate and academic partnerships;

         o        minimizing early capital needs by obtaining stable and
                  radioactive isotopes through alliances and supply agreements
                  with existing stable and radioactive isotope sources, followed
                  by investment in Company-owned isotope production facilities
                  when markets are more established and the optimum production
                  technology has been determined;

         o        obtaining value-added processing technology through
                  sub-contract manufacturing agreements, joint ventures, and
                  acquisitions of strategically important technologies and
                  companies; and

         o        developing a time-balanced product pipeline to provide a
                  continual supply of new business opportunities.


PRODUCTS

         Depleted zinc sales historically were our most significant source of
revenues. However, in fiscal 1999, our revenues were generated from a more broad
range of sources, including depleted zinc sales (approximately 35%),
radioisotopes sales (approximately 34%), and other stable isotopes sales
including our newly introduced silicon-28 isotope (approximately 15%). In fiscal
2000, this trend continued as our revenues were again generated from a broad
range of sources, including depleted zinc sales (approximately 21%),
radioisotopes sales (approximately 46%), and other stable isotopes sales
including oxygen-18 and silicon-28 (approximately 24%). The balance of our
revenues came from the operations of our subsidiary, Interpro (approximately 16%
in FY 1999 and 9% in FY 2000). Interpro performs metallurgical and mineral
processing contract research and process analysis test work.

         Because we sold our depleted zinc business in December 1999, depleted
zinc, which was a significant source of revenues in both fiscal 2000 and fiscal
1999, will cease to be a source of revenues in fiscal 2001, and subsequent
fiscal years. Additionally, effective May 1, 2000, we reorganized Interpro.
Interpro will now focus exclusively on developing a new technology to recover
and recycle zinc metal from various sources including galvanized scrap steel. We
do not anticipate any revenues from Interpro in fiscal 2001. However, we believe
the revenue potential in subsequent years is significant.


LIFE SCIENCES PRODUCTS

         For the past several years, we have supplied stable isotopes in
elemental and simple compound forms for use in life science applications. With
the acquisition of Chemotrade in 1998, we expanded our product offerings to
include radioisotopes. We will continue selling our current stable and
radioactive isotope products, develop new products along similar lines, and
expand our product offerings by vertically integrating. We also intend to expand
our own isotope production capabilities. In addition, we intend to expand our
value-added manufacturing capabilities. A brief summary of existing and emerging
life sciences products follows:

STABLE ISOTOPE LABELED COMPOUNDS. Stable isotope labeled compounds ("SILCs") are
created by incorporating known quantities of certain stable isotopes of carbon,
nitrogen, hydrogen (deuterium), oxygen, and other elements, into thousands of
different chemical compounds. SILCs allow researchers to investigate living
systems, determine the chemical structure of important biological compounds,
design new drugs, and measure extremely low levels of environmental toxins. We
believe that greater availability and lower cost of stable isotopes, and
advances in instrumentation to detect stable isotopes will continue to increase
the demand for SILCs.

         Our products are typically simple compound SILCs that are used by our
customers to synthesize more complex and higher-value SILCs. We primarily market
deuterium, carbon-13, and nitrogen-15 for this purpose. In



the near term, this strategy of supplying simple compound SILCs will
continue. Examples of existing and emerging applications for these products
include:

                  METABOLIC STUDIES. Increasingly, studies of new drugs are
                  performed with isotope-labeled drugs to facilitate research on
                  metabolism, distribution, mode of action, and elimination. The
                  FDA may eventually require the isotope labeling of all new
                  drugs for investigational use during some or all phases of
                  pre-clinical and clinical evaluations of these drugs. However,
                  there can be no assurance that the FDA will make this mandate
                  in the near future, if at all.

                  RATIONAL DRUG DESIGN. Historically, drugs were designed using
                  a screening process in which prior experience was employed to
                  determine what chemicals might work to treat a certain
                  condition, and then tests on subjects were performed. Today
                  specialized instrumentation is routinely available to
                  determine the chemical structure of large molecules, including
                  the human proteins and enzymes that a drug will be designed to
                  affect. This approach is known as rational drug design. We
                  believe that this new instrumentation, combined with
                  sophisticated SILCs, will prove beneficial in determining the
                  chemical structure of human proteins and enzymes. We believe
                  rational drug design will require an increasing supply of
                  stable isotopes.

DIAGNOSTIC BREATH TESTS (DBTs). This new class of non-invasive diagnostic
testing is gaining worldwide acceptance. It uses stable isotope labeled
compounds to detect a wide range of human abnormalities, particularly digestive
disorders such as ulcers. The FDA has approved one test and similar approvals
exist in Europe. Reimbursement by health insurance providers for the test has
led to increased growth in demand that is expected to accelerate as regulatory
approval is awarded in other countries (such as Japan). Many other tests based
on the same principles are in various stages of development. We have supplied
stable isotope raw material to companies developing various DBT chemicals. While
this is not currently a large source of revenues, we continue our sales and
marketing efforts in order to monitor the development and direction of this
potentially very large market.

         The DBT business is subject to extensive government regulation. The
products and instruments in which our products are used, which may be regulated
as drugs and devices, are subject to the scrutiny of FDA review and approval, as
well as ongoing FDA inspection of most aspects of the production, marketing,
distribution, and usage. We believe that the production and marketing of DBTs
are also subject to similar regulatory controls in the foreign countries where
we would possibly seek to market products. Consequently, new products cannot be
commercially introduced until after approval (usually several years), and there
can be no assurance that the products will be approved for use.

BIOMEDICAL RESEARCH. Traditionally, numerous aspects of the many phases of drug
development have been carried out using radioisotope-labeled versions of
promising compounds. Isonics supplies precursor compounds labeled with
radioisotopes, such as carbon-14 and phosphorous-33, to manufacturers who
incorporate them into more complex radioisotope labeled compounds for use in
basic research and pharmaceutical development. The carbon-14 precursors are
produced under contract by IUT, a company in which we hold a minority interest.
While rational drug design and stable isotope labeled compounds represent
competition for this more traditional approach to research and drug development,
we believe a combination of increasing drug development activity and the large
body of data and experience will ensure a strong market for these products. It
is important to note that we also supply some of the basic stable isotope
products used to make the compounds of these competing technologies.

MEDICAL IMAGING AND THERAPY. Radioisotopes have been used for years in the
diagnosis and treatment of many medical conditions in humans. The trend in these
two areas has been towards increasingly more specific chemicals, which, after
labeling with the radioisotope and injection into the patient, quickly
concentrate at the disease site(s). In theory, the appropriate choice of
chemical and radioisotope labels would allow disease detection and stage
determination; followed by therapy selection, administration, and monitoring.
Several classes of chemical compounds ranging from monoclonal antibodies to
peptides, most recently, are being developed, tested,



and approved for use in the detection, and eventually, the treatment of many
diseases.

         We currently supply stable isotopes of thallium, zinc, cadmium, xenon,
strontium, and many others that are routinely used in a variety of medical
imaging and therapy applications. These are used in their enriched stable form,
such as Xenon-129, or converted to a specific radioactive isotope in a cyclotron
or nuclear reactor. We believe that with the increased supply of new isotopes,
and the ongoing development of highly specific biochemical therapies, this
market segment represents a major growth opportunity.

POSITRON EMISSION TOMOGRAPHY ("PET"). This very powerful nuclear medicine
imaging technology has been available for over 25 years, but because of its
complexity and cost, had been limited primarily to a research role. Technology
and infrastructure improvements have reduced the cost and complexity of
performing PET studies. PET's unique ability to diagnose multiple metabolic
abnormalities, particularly cancer, has resulted in recent approvals by the FDA
and favorable reimbursement levels by Medicare, Medicaid, and third party
insurers. Similar approvals are now common in Europe and parts of Asia though
reimbursement levels vary. PET studies are growing at rates of approximately 20
to 50% annually worldwide.

         Oxygen-18, a rare stable isotope of oxygen, is the enriched stable
isotope used to produce the radioisotope, fluorine-18, which is the source of
the positrons tracked by the PET imaging equipment. Currently demand for
oxygen-18 is greater than the supply. To address the demand for oxygen-18, we
announced in May 1999, a multi-year joint cooperation agreement with Global
Scientific Technologies in Russia. We believe we are now the second largest
producer of oxygen-18 in the world. Our oxygen-18 production capacity continues
to increase as a result of production facility additions and a novel program we
introduced in fiscal 1999 that recycles "used" oxygen-18.

         In August 2000, we announced that we signed a five-year agreement with
the Ukraine-based Concern Stirol and Medeleev Institute of Moscow, Russia, for
the production, marketing and sale of oxygen-18.

         Although there is currently little FDA oversight affecting the raw
material suppliers, it is likely FDA oversight will increase in the next few
years. It is not immediately obvious what the implications may be for our
production partner and us.

BRACHYTHERAPY. Cancer therapy continues to evolve to more effectively target
specific types of cancer. Radioisotope labeled compounds promise great advances
in focused treatment, but are still well in the future. Today, external beam
radiotherapy and chemotherapy are the predominant technologies used in cancer
treatment. However, another technology, brachytherapy, is emerging in the
treatment of specific cancers such as prostate cancer.

         In brachytherapy, small sealed sources (or seeds) are inserted directly
into the tumor using a variety of minimally invasive surgical methods. The
radioisotope, which is placed inside the seed, is selected and manufactured to
ensure that only the cancerous tissue immediately adjacent to the implanted seed
is irradiated. This minimizes the irradiation of nearby healthy tissue, a common
adverse side effect, which occurs with external beam radiotherapy. Three primary
criteria govern the selection of the radioisotope: half-life, type of radiation
emitted, and strength of the radiation emitted. The half-life and form of
radiation emitted is dictated by the radioisotope selected. Strength of the
radiation is determined during the manufacturing process.

         Several companies (Nycomed-Amersham, Theragenics, North American
Scientific, International Isotopes, Inc., and others) already offer or have
announced plans to offer brachytherapy products for the treatment of certain
forms of prostate cancer. Studies continue in the applicability of this
technique for other tumor types, including some breast and eye cancers. We
currently supply several companies with radioisotopes (or stable isotope targets
to be made into radioisotopes) for this application. We believe this market
represents one of the largest growth opportunities for radioisotopes. It also
represents a significant opportunity to provide value-added



products/services in the form of manufactured subcomponents such as the seeds.

CALIBRATION STANDARDS. There are many medical devices that measure levels of
radiation in patients. These devices all need to be calibrated using standards
of known radiation strength and type in order to ensure their accuracy. These
standards are made from radioisotopes such as cobalt-57 and gadolinium-153. We
supply many of the stable isotope target materials, as well as radioisotopes, to
many of the manufactures of these standards. We also distribute the finished
products of one of these manufacturers in certain regions of Europe.
Additionally, we distribute the source standards products of a major
manufacturer that recently announced the sale of its industrial source business.

         Medical equipment calibration standards is one of the largest markets
for radioactive source standards. These medical devices are found in the nuclear
medicine departments at thousands of hospitals around the world. The continued
growth in the numbers and complexity of nuclear medicine imaging equipment,
especially PET, ensure growth in the demand for these radioisotopes.

PRODUCT TAGGING AND STEWARDSHIP APPLICATIONS

         Thousands of chemicals used everyday in our society are fungible. That
is, these chemicals cannot be differentiated from those produced by another
manufacturer, or even by the same manufacturer on a different day. These
chemicals, and the products made from them, may be identified and distinguished
from each other, by tagging with known amounts of stable isotopes of carbon,
nitrogen, oxygen, hydrogen, and other elements.

         Alternative tagging methodologies are in use today. These methods
typically involve the addition of extraneous materials such as dyes, exotic
chemical compounds, or radioactive compounds. We believe that adding these
extraneous materials can sometimes detract from the performance of the product,
and/or create undesirable side effects. Creating the product with chemicals made
with specific ratios of stable isotopes results in a unique, easily identified
tag. A tag that is also chemically identical--ensuring comparable performance
with no undesirable side effects.

         To date, we have not had significant demand for our stable isotopes for
these applications. We believe the opportunity exists for demand to develop in
many areas. One example is high-value, low-volume products such as perfumes.
Imitation perfumes, made by other manufacturers, but sold as the original to
unsuspecting consumers, are not uncommon. If the original perfume has been
tagged using stable isotopes, then imitations can be easily identified.

         Another example is where information regarding the manufacture and
distribution of a chemical is important. Ammonium nitrate is a common
fertilizer. However, when combined with fuel oil, it becomes a powerful
explosive. Knowing by whom, when, and where the Ammonium nitrate was made, and
to which distributor it was sold, can be very useful information if authorities
need to investigate the unlawful use of such an explosive. Tagging the Ammonium
nitrate with stable isotopes would provide that information, even after the
explosive was used, as the isotopic ratios are unaffected by an explosive
reaction. These, and other product tagging and stewardship applications may also
develop over time.


INDUSTRIAL APPLICATIONS AND BASIC RESEARCH.

CALIBRATION STANDARDS (NON-LIFE SCIENCES). In addition to the life sciences
calibration standards market described above, numerous industrial applications
also use radiation, and/or measure radioactivity levels. As with life sciences
standards, we supply many of the stable isotope target materials and
radioisotopes used in these applications. As mentioned above, we also distribute
the source standards products of a major manufacturer that recently announced
the sale of its industrial source business.



BASIC RESEARCH. There is still much scientists do not know about radioactive
materials, and how to minimize the dangers associated with these materials. We
provide rare radioisotope standards to entities that study these issues. To date
this has been a significant source of revenues.


ISOTOPICALLY PURE SEMICONDUCTOR MATERIALS

         The majority of semiconductor devices built today use natural silicon
as the starting material. Silicon has many desirable characteristics as compared
to other semiconductor materials, and the semiconductor industry has invested
billions of dollars to improve and optimize their manufacturing technologies for
silicon-based devices. Devices fabricated on single crystal silicon have
performance characteristics that are governed by the electrical and physical
characteristics of silicon including: carrier mobilities, effective mass of the
carriers, energy band-gap, electrical conductivity, and thermal conductivity.
Carrier mobilities, for example, govern signal transit times and thus place a
limit on device speed. Thermal conductivity governs power dissipation, which, in
turn, places an upper limit on the packing densities achievable for devices on a
chip, or the amount of power that can safely be generated in the circuit without
significantly degrading circuit performance.

         The semiconductor industry trend of adding more transistors on a chip
to increase performance, and shrinking the size of transistors to both increase
performance and decrease costs, has resulted in increased power requirements and
significantly higher operating temperatures. Nowhere is this trend more evident
than in microprocessors. Historically, the 80286, 80386, and 80486 generations
of microprocessors typically did not need external heat sinks to remove heat and
function properly. High operating temperatures and thermal management were not
issues outside of mainframe or workstation computers.

         Beginning with the Pentium(R), Sparc(R), and Alpha(R) microprocessors,
heat sinks and fans became necessary to control the higher operating
temperatures. According to the Semiconductor Industry Association (SIA), when
the microprocessor's power requirements exceed approximately 110 watts, heat
sinks and fans will no longer be adequate and active cooling (refrigeration)
will be required. Most of the major computer companies have already demonstrated
cryogenically cooled computers that operate up to one-third faster than their
conventionally cooled counterparts. These cryogenic cooling devices can cost
upwards of $400 per microprocessor.

         There is a significant body of research, generated over the last twenty
years, supporting the contention that isotopically pure semiconductor materials
have superior thermal conductivity properties when compared to natural,
multi-isotopic materials. Additionally, we believe this solution is compatible
with virtually every other heat management solution currently implemented, or
envisioned to date, and it does not require changing a single device design or
manufacturing process because pure silicon-28 is essentially identical--
chemically and physically--to natural silicon. SEE "RESEARCH AND DEVELOPMENT."

         Silicon has three naturally occurring stable isotopes: silicon-28 (92%
natural abundance), silicon-29 (5%) and silicon-30 (3%). In 1997, we began a
program to introduce 99.9% isotopically pure silicon-28 as a superior substitute
material, to natural silicon, for the manufacture of semiconductor devices. Our
first efforts toward developing isotopically pure semiconductors involved
securing the intellectual property rights to commercialize silicon-28 and
similar materials, which culminated in our acquiring exclusive rights to two
Yale University patents. SEE "PATENTS AND PROPERTY RIGHTS."

         We then began acquiring sufficient quantities of pure silicon-28 to
make epitaxial wafers. These wafers have been sold or given to numerous
manufacturers and academic institutions to perform additional tests to validate
previous findings, and to confirm the substitutability of pure silicon-28 for
natural silicon in their manufacturing processes. These tests have supported our
belief that pure silicon-28 is not only a viable substitute material for natural
abundance silicon, but that the anticipated thermal conductivity property
improvements are



significant.

         The next step in our development program is to make bulk wafers of pure
silicon-28. However, the manufacture of bulk wafers requires substantially more
material than we could economically acquire from our existing suppliers. Our
efforts to secure an unlimited, U.S.-based, economical supply of silicon-28
culminated with the December 1999 signing of an agreement with Eagle-Picher to
provide silicon-28 to us, from its pilot plant, on an exclusive basis. The
initial 200-kilogram delivery was scheduled for delivery by December 31, 2000.
Eagle-Picher failed to make timely delivery of this amount. We know that
Eagle-Picher's silicon-28 production facility in Oklahoma has encountered
certain technical difficulties, which Eagle-Picher refers to as a FORCE MAJEURE.
We believe that Eagle-Picher's technical difficulties do not meet the definition
of FORCE MAJEURE per our agreements, which would entitle Eagle-Picher to a delay
in the delivery requirement. We have invoked the dispute resolution process
called for in the Supply Agreement to resolve this and other related issues. SEE
"SALE OF DEPLETED ZINC BUSINESS" AND "MANUFACTURING AND SUPPLY."

         Converting silicon-28 from the chemical and physical form we receive
from our suppliers into epitaxial wafers required us to use several contract
manufacturers. We believe that we can perform many of these processes ourselves
at a lower cost and with greater quality assurance. Therefore, we are building a
processing facility in Golden, Colorado to perform many of these processes.
Equipment was ordered, construction has commenced, and we expect this facility
to be completed sometime before April 2001. We will then be able to manufacture
sufficient quantities of pure silicon-28 silane gas to produce bulk wafers, in
addition to more epitaxial wafers, to complete our development efforts.

         Our agreement with Eagle-Picher provides that they will supply to us
all quantities of silicon-28 that they produce from their pilot plant at
previously agreed upon prices. Their isotope separation process is such that, if
Eagle-Picher's production is successful, it is easily expanded at their facility
in Oklahoma. Additionally, we have worked with Silex Systems, Ltd., North Ryde,
Australia, ("Silex"), who is developing a different silicon isotope separation
process. We believe these companies, and others, will be able to supply all the
silicon-28 that we may require, although none of these facilities have yet
commenced commercial production.

         We also believe that once sufficient orders have been placed for pure
silicon-28 bulk wafers, that one or more wafer manufacturers will convert one or
more of their facilities to produce such wafers. Therefore we intend to focus on
developing and expanding the production processing steps that precede wafer
manufacturing. The expertise that we expect to develop running our
developmental-scale facility should prove sufficient for this purpose.

         We anticipate very little revenue from silicon-28 based products in
fiscal 2001, as we are still developing this business. However, we project
significant revenues in subsequent periods if we are able to successfully
complete our development efforts, and market silicon-28 based products. We have
also begun examining other semiconductor materials including gallium. As with
silicon, gallium has multiple, naturally occurring stable isotopes. Our
development program for gallium, which we began in April 2000, is similar to the
one outlined above for silicon-28. At this time we have begun identifying
sources and procuring small amounts of isotopically pure gallium-69 and
gallium-71.


ZINC RECOVERY AND RECYCLING BUSINESS OPPORTUNITY

         We have pursued a business opportunity in our efforts to develop an
economic zinc recovery and recycling technology, which can capture the full
value of zinc in waste products and sell high purity zinc metal in response to
the increasing demand for this metal. The recovery and recycling technology that
we are developing avoids most of the disadvantages of conventional processes; is
applicable to a wide range of zinc-bearing scrap, dust, and sludge; and may
generate additional revenue by enhancing the value of the associated materials
in other zinc-



bearing waste streams. For various economic factors discussed above in
MANAGEMENT'S DISCUSSION AND ANALYSIS - REORGANIZATION OF INTERPRO SUBSIDIARY
and elsewhere herein, we have concluded that the research and development
necessary to pursue this product opportunity may not be affordable to Isonics
at this time. Until we are able to sell our Interpro subsidiary on reasonable
terms, however, we intend to continue to pursue this zinc recovery and
recycling opportunity.

         Zinc metal is the fourth most widely used metal in the world today
(after iron, copper and aluminum). Zinc's primary use is galvanizing, a process
where zinc is used to form a protective coating on steel. Zinc along with
copper, are the two primary components in brass. Zinc is also used in
die-casting alloys, chemicals, and pharmaceuticals, and is used to make coins
and batteries. Zinc is an essential element for most living organisms: in
mammals it promotes healthy growth, and it is an important nutrient for many
cultivated plants.

         Because of these diverse applications zinc tends to be dispersed in
usage, and therefore, is probably the least recycled primary metal. However, the
demand for zinc has shown steady growth, and this demand has been principally
met by primary production (mining and refining). The world production of zinc
metal is currently seven million tons per year, which is sold for approximately
$1,100 per ton -- an annual market of approximately $7.7 billion. Between 15%
and 30% of this amount is produced by recycling, primarily from zinc
die-castings. The United States uses 660,000 tons per year ($726 million) of
zinc metal for galvanizing while the world consumption for galvanizing is
estimated at 1.65 million tons ($1.8 billion). Over the past twenty years the
increase in galvanizing consumption worldwide has been approximately 3.4% per
year. Corresponding increases in quantities of zinc associated with scrap are
apparent, particularly in materials being recycled to steel plants.

         During the course of its contract research and development activities,
Interpro was introduced to a patented technology using chlorine gas to recover
and recycle zinc from galvanized steel scrap. At high temperatures (600 to 800
degrees Centigrade), chlorine reacts with the zinc coating (galvanizing) on
steel to form a zinc chloride vapor. The vapor is collected and processed to
produce pure metallic zinc for sale, and chlorine for sale or reuse in our
recovery process.

         We believe that the new technology has a number of benefits compared to
conventional zinc scrap recycling processes:

         o        it can be applied to a variety of zinc-bearing waste materials
                  in addition to galvanized steel scrap;

         o        it enhances the value of the associated materials (zinc-free
                  scrap steel is much easier and less costly to recycle);

         o        it can use waste plastic (as a source of chlorine and heat)
                  that would  otherwise be sent to a landfill;

         o        it recovers chlorine for sale (to make more plastic, for
                  example) or reuse within our process; and

         o        the final product is high purity metallic zinc which can be
                  sold to any of the current zinc markets identified above.


         In addition, our preliminary economic evaluations indicate that zinc
can be recovered and recycled by this technology at a lower unit cost than
current primary production (mining and refining of zinc-bearing ores).

         Current zinc recycling processes generally cannot produce high purity
zinc metal. One reason is that chlorine, which is detrimental to the commonly
used zinc refining process, is often present in zinc-bearing dusts and residues.
These materials require an alternative recovery and recycling process. In
addition, zinc has a low boiling temperature compared to other metals.
Therefore, in high temperature processing, zinc frequently



concentrates as a fume or dust along with other volatile impurities. Hence,
recycled (secondary) zinc is often used only to produce zinc chemicals, plant
nutrients, and impure zinc oxides. Impure zinc oxides are also sold to
primary zinc refiners, but at a considerable discount.

         The original concepts for this new technology were devised and patented
by Professor Derek Fray of the Department of Materials Science and Metallurgy at
the University of Cambridge, Cambridge, England. We are conducting an intensive
program to confirm that the processes described in the patents can be performed
at a larger scale, in both batch and continuous modes, in our laboratories and
pilot plants. We are now negotiating with Professor Fray, and other parties, for
an exclusive license to develop and use this technology in North America and
Europe. As our development program progresses, we plan to file applications for
new patents, where appropriate, to protect our position in regard to this
technology.

         It was originally our intention to develop this technology, using our
current facilities at the appropriate pilot plant level of operation, and then
use the anticipated results of the pilot plant program (if successful) to
attract strategic investors in this technology. It was then our intention to
sell, spin-off or otherwise divest this business to one or more strategic
investors. While we believe the economic potential of this, and related
technologies, is significant, this line of business is not consistent with our
core isotope business. We believe this approach will maximize shareholder value
both today and in the long-term.

         We are presently considering alternatives for Interpro, and the zinc
recovery business, because of its significant negative cash flow and the failure
to attract any outside investors. Management estimates the negative cash flow
directly attributable to the zinc recovery project to be approximately $100,000
per month. It is also Management's opinion that outside investors are reluctant
to invest in the zinc recovery business as long as it is part of Isonics.

         These alternatives include selling a portion or all of the zinc
recovery business to a management group that will assume the related assets,
liabilities, and all subsequent expenses and costs of developing the zinc
recovery business. Although this offer will not result in the payment of any
cash to Isonics as a part of the purchase price, it will relieve us from a
monthly negative cash flow, certain long-term liabilities, and (by retaining a
25% interest) will provide us with an opportunity to benefit from any success
achieved by the purchasers. The Board of Directors has accepted such an offer
subject to the finalization of acceptable terms, the preparation of a "fairness
opinion," and the possible submission of the matter to, and approval by, our
shareholders.

         In the quarter ended October 31, 2000, we recognized a $270,000 expense
to remediate the Golden, Colorado facility we currently lease. This expense will
be incurred prior to the expiration of our lease in June 2001. In the event that
the zinc recovery business is sold, this would become the obligation of the
management group proposing to buy the zinc recovery business.


ISOTOPICALLY DEPLETED ZINC

         The U.S. Nuclear Regulatory Commission requires that nuclear power
plants reduce the radiation exposure of the nuclear power plant workers to
levels as low as reasonably achievable. Also of significant concern is the
cracking of nuclear power plant structural materials because of the corrosive
nature of the water used to cool the nuclear reactor core. Nuclear power plants
are designed with substantial safety margins against such cracking, and frequent
surveillance is performed to ensure that these safety margins are not
compromised. However, if not controlled, cracking can require extremely costly
repairs or, if not reparable, could result in the premature shutdown and
de-commissioning of a facility which may have cost hundreds of millions of
dollars, or more, to construct.



         Testing sponsored by the Electric Power Research Institute showed that
the addition of a soluble form of zinc to the nuclear reactor coolant water
reduces plant radiation fields, and in some cases, substantially mitigates
environmentally induced cracking because zinc acts as a corrosion inhibitor for
the stainless steel and other metal components of the nuclear reactor systems.
Natural zinc provides the important benefits outlined above, but one isotope of
natural zinc becomes radioactive in the nuclear reactor, thus offsetting a
substantial portion of the desired benefits. By depleting this zinc isotope, the
desired corrosion-resistance benefits are still obtained while the detrimental
side effect is essentially eliminated. This product is known as isotopically
depleted zinc. In calendar year 1999, isotopically depleted zinc was used by 35
of the approximately 95 Boiling Water Reactors (or "BWRs") in the world
including 29 of the 35 BWRs in the United States.

         Effective December 1, 1999, we sold our depleted zinc business to
Eagle-Picher. SEE "MANAGEMENT'S DISCUSSION AND ANALYSIS - SALE OF DEPLETED ZINC
BUSINESS."


RESEARCH AND DEVELOPMENT

         Consistent with our product development strategy, we are seeking to
identify and evaluate a variety of new stable and radioactive isotope products
and potential markets for economic and technical feasibility. We will also
continue to fund research and development to improve technologies for isotope
separation and materials processing technologies. During fiscal 2000 and 1999,
research and development expenses were $1.224 million and $1.155 million,
respectively.

         In fiscal 2000, we focused our efforts on two primary projects. The
first project is the production of high chemical-purity silicon-28 silane gas
and silicon-28 epitaxial wafers. The second project is the recovery and
recycling of zinc from various sources such as scrap metals, including
galvanized steel and brass, and electric arc furnace dust. Both of these
projects are still underway as of the date of this prospectus.

         In fiscal 1999, we focused our efforts on three primary projects. The
first was procuring silicon-28 and producing silicon-28 epitaxial wafers. The
second was developing new, lower-cost carbon-13 separation methods. The third
was development work to enhance our depleted zinc processing capabilities. The
silicon-28 project was successful. Work in this area continued throughout fiscal
2000, and is continuing through the current (2001) fiscal year. The carbon-13
separation project did not produce the desired results and was ended in February
1999. The depleted zinc project was completed in November 1998.

SILICON-28. To expand our capacity and to ensure product quality, we have begun
building our own silane gas facility in Golden, Colorado. We believe this
facility will be capable of processing isotopically pure silicon-28, to meet our
requirements for the next few years as we continue our planned development
program for silicon-28 semiconductor materials. To date, unaffiliated
contractors have performed this work for us on a sub-contract basis. However, we
have attempted to retain, to the maximum extent possible, ownership of any
intellectual property resulting from such work.

         In fiscal 2000, we funded two new university research programs and
participated in two others. The first funded program is at Southern Methodist
University, Dallas, Texas, which will measure the thermal conductivity of
silicon-28 thin films with various electrical dopants, and model the effect of
epitaxial layer thickness on the temperature of silicon and gallium arsenide
transistors. The second funded program is at North Carolina State University,
Raleigh, North Carolina, which will model and build power semiconductor devices
and determine the effect of silicon-28 epitaxial layers on the device's
temperature distribution.

         Additionally, we entered into a Cooperative Research & Development
Agreement ("CRADA") with Lawrence Berkeley Laboratory, Berkeley, California, to
study the properties of various silicon isotopes. This CRADA is part of a U.S.
Department of Energy ("DOE") program to re-deploy Russian nuclear weapons



technology to commercial applications. Delays within the DOE have pushed the
start of this program to our fiscal year 2001.

         We also supplied silicon-28 silane gas to ATMI, Inc., Danbury, CT,
and will be participating in their Office of Naval Research ("ONR") funded
program to investigate isotopically pure silicon carbide.

         During fiscal 1999, we signed a joint research and development
agreement with Silex Systems, Ltd. The agreement calls for Silex to partially
fund some of our development activities and for Silex to assess the
feasibility of building a silicon isotope separation plant using Silex's
patented laser isotope separation process. These agreements represent the
launch of our efforts to ensure a large supply of silicon isotopes at a
reasonable cost to support the large-scale manufacture of isotopically pure
silicon wafers.

         Additionally, we signed an agreement with Voltaix, Inc., North
Branch, New Jersey, ("Voltaix") to be the distributor of our products for the
ion implantation industry. The first product being sold in accordance with
the Voltaix agreement is silicon tetrafluoride enriched in the silicon-29
isotope. The isotopically enriched materials allow higher beam currents and
higher productivity than the natural silicon tetrafluoride currently used in
the industry today.

ZINC RECOVERY AND RECYCLING. During the course of its contract research and
development activities Interpro was introduced to a patented technology using
chlorine gas to recover and recycle zinc from galvanized steel scrap. We have
dedicated the staff and facilities of Interpro to focus primarily on this
project. The original concepts for this new technology were devised and
patented by Professor Derek Fray of the Department of Materials Science and
Metallurgy at the University of Cambridge, Cambridge, England.

         As described above, we believe this new technology has numerous
benefits compared to conventional zinc scrap recycling processes, but we do
not believe that Isonics is currently in a position to complete the necessary
research and development to pursue these opportunities. Consequently (also as
described above), we are considering selling our Interpro subsidiary to a
management group. We will continue our research and development in this area
(to the extent permitted by our resources) until the sale has been completed.

PATENTS AND PROPRIETARY RIGHTS

         We rely primarily on a combination of trade secrets, confidentiality
procedures, and contractual provisions to protect our technology. Despite our
efforts to protect our rights, unauthorized parties may attempt to copy
aspects of our products or to obtain and use information that we regard as
proprietary. Policing unauthorized use of our technology and products is
difficult. In addition, the laws of many countries do not protect our rights
in information, materials and intellectual property that we regard as
proprietary and that are protected under the laws of the United States. There
can be no assurance that our means of protecting our rights in proprietary
information, materials and technology will be adequate or that our
competitors will not independently develop similar information, technology,
or intellectual property.

         We currently have no patents in our own name and have not filed any
patent applications. We have rights to several isotopically engineered
innovations regarding electronic and optical materials that we believe may be
patentable. Ongoing work in the area of isotope separation by chemical means
may also lead to patentable inventions. In such cases, we intend to file
patent applications for some of these modifications, improvements, and
inventions and to protect others as trade secrets. There can be no assurance,
however, that patents on such modifications, improvements, or inventions will
be issued or, if issued, that such patents or modifications and improvements
protected as trade secrets will provide meaningful protection.

         Third parties may have filed applications for or have been issued
patents and may obtain additional



patents and proprietary rights related to products or processes competitive
with or similar to those of Isonics. We may not be aware of all patents
potentially adverse to our interests that may have been issued to others and
there can be no assurance that such patents do not exist or have not been
filed or may not be filed or issued. If patents have been or are issued to
others containing preclusive or conflicting claims and such claims are
ultimately determined to be valid, we may be required to obtain licenses
thereto or to develop or obtain alternate technology. There can be no
assurance that such licenses, if required, would be available on commercially
acceptable terms, if at all, or that we would be able to develop or obtain
alternate technology, which would have a material adverse effect on our
business.

         There can be no assurance that the validity of any of the patents
licensed to, or that may in the future be owned by us would be upheld if
challenged by others in litigation or that our products or technologies, even
if covered by our patents, would not infringe patents owned by others. We
could incur substantial costs in defending suits brought against us, or any
of our licensors, for infringement, in suits by us against others for
infringement, or in suits contesting the validity of a patent. Any such
proceedings may be protracted. In any suit contesting the validity of a
patent, the patent being contested would be entitled to a presumption of
validity and the contesting party would be required to demonstrate invalidity
of such patent by clear and convincing evidence. If the outcome of any such
litigation were adverse to our interests, our business would be materially
adversely affected.

         In certain instances, we may choose not to seek patent protection
and may rely on trade secrets and other confidential know-how to protect our
innovations. There can be no assurance that protectable trade secrets or
know-how will be established, or if established, that they will remain
protected or that others will not independently and lawfully develop similar
or superior innovations. We require all employees to sign intellectual
property assignment and non-disclosure agreements. In certain instances, we
will enter into agreements with our employees pursuant to which the employee
will be entitled to a small royalty with respect to products developed by
Isonics based upon the employee's inventions. In addition, all directors,
consultants and other parties to whom confidential information has been or
will be disclosed have or will execute agreements containing confidentiality
provisions. There can be no assurance, however, that any such intellectual
property assignment agreements and confidentiality agreements will be
complied with or will be enforceable.

         In April 1999, we announced that we had entered into an exclusive
licensing agreement with Yale University that entitles us to exclusive
intellectual property rights to patents covering semiconductor devices
derived from isotopically engineered materials. The license requires payment
by us of a royalty based on a percentage of our, or our sublicensees', net
sales of products derived from technology covered by the Yale patents
(#5,144,409, dated September 1, 1992, and #5,442,191, dated August 15, 1995).

COMPETITION

         The markets for our products and proposed products are highly
competitive, and we expect that competition will continue and likely increase
as markets grow and new opportunities are realized. Some of our current
competitors, and many of our potential competitors, are larger and have
significantly greater financial, technical, marketing, and other resources
than we do. Some of our competitors may form partnerships or alliances with
large pharmaceutical or electronics companies, with the resulting entity
possessing more market strength than we have. Our competition varies greatly
depending on which product or industry is considered.

SILCs AND DBT MATERIALS. We have several larger and numerous smaller competitors
in the markets for our SILC products. We will have additional competitors if we
offer breath test diagnostic products (DBTs), and additional SILCs in the
future. Two of these companies, Cambridge Isotope Laboratories Inc., and Isotec,
Inc., have their own isotope separation facilities, while all of our competitors
produce some combination of SILCs and DBT



substrates. We are aware of at least one company in the United States who has
received FDA approval for a carbon-13 Urea Breath Test ("UBT"), a specific
type of DBT. Several companies in Europe have also received regulatory
approval for DBTs. Our principal current competitors and potential
competitors also include: MassTrace, euriso-top, Aldrich Chemicals, Icon
Services, Omicron, C/D/N Isotopes, and Martek Biosciences. We have in the
past, and may in the future, sell products to, or purchase products from,
these companies.

SEMICONDUCTOR MATERIALS. Because of the early stage of the semiconductor
materials opportunities, we have not identified significant competitors in
these markets. Numerous companies in the United States and throughout the
world are currently manufacturing semiconductor materials and are known to be
conducting research and development to improve the thermal conductivity and
other beneficial characteristics of semiconductor materials. Many of these
companies are larger than Isonics and have significantly greater financial
resources available. Given the potential size and importance of these new
potential markets, we anticipate that substantial additional competition will
emerge if these markets develop. We believe one of the most important
benefits isotopically pure semiconductor materials are expected to provide is
higher thermal conductivity. This higher thermal conductivity helps alleviate
the heat dissipation problem in high-power density semiconductor devices.
Many mechanical methods have been employed to date including fans, heat sinks
and refrigeration units to dissipate heat. These alternative methods, as well
as others which have come to our attention, we believe without exception,
will prove to be complementary to our materials-based solution, and the
benefits will be additive.

ZINC RECOVERY AND RECYCLING. Over the last twenty years, many organizations
have attempted to recover and recycle zinc from galvanized steel and brass
scrap. Many of these organizations are larger than Isonics and have
significantly greater financial resources available. These methods have
proven either cost ineffective, or difficult to implement, because of the
complex metallurgy involved. Additionally, primary zinc from ore deposits
around the world continues to be relatively inexpensive and plentiful. These
companies are also larger than Isonics and also have significantly greater
financial resources available. We believe we will not only have to produce
significant cost savings, versus primary zinc, we will also have to
demonstrate significant benefits of our proposed technology to the steel, and
other zinc-consuming, industries. Our research and development efforts in
this area are in their preliminary stages and we can offer no assurance that
the will be successful.

DEPLETED ZINC. During fiscal 2000 (through November 1999), we were among the
leading producers of depleted zinc. We also believed that other entities or
persons were expected to begin producing depleted zinc in substantial
quantities in the near future. Several such possible producers have adequate
technical and financial resources to become viable competitors in the near
future. In particular, Siemens has indicated that it has a relationship with
Ultracentrifuge Netherlands ("UCN") and General Electric Corporation has
indicated that it may establish a second Russian supply source. UCN also
competes with us in the markets for medical target isotopes. This competitive
environment, along with many other factors, contributed to our decision to
sell our depleted zinc business to Eagle-Picher Technologies, LLC, in
December 1999.

SUMMARY. Many of the areas in which we do, or intend to, compete are rapidly
evolving. There can be no assurance that an existing or potential competitor
has not already developed, or may develop, a patentable product or process,
which will substantially prevent us from competing in our intended markets.

         We expect to compete primarily on the basis of product performance,
proprietary position, and price. Some of our products may also compete based
on product efficacy, safety, patient convenience, and reliability. In many
cases the first company to introduce a product to the market will obtain at
least a temporary competitive advantage over subsequent market entrants.

MANUFACTURING AND SUPPLY

         Consistent with our strategy to effectively utilize capital
expenditures and production facilities, we obtain



our isotopes through several multi-year supply agreements with third parties.
To a lesser extent, from time-to-time, we also obtain stable isotopes from a
variety of other isotope sources, primarily located in Russia, on a spot
market basis. We may invest in our own isotope production facilities in the
future upon determining, in our opinion, the optimum production technology
for a given isotope or family of isotopes.

         Currently, we obtain substantially all of our isotopes from Russia,
Georgia, Uzbekistan, and other locations within the former Soviet Union. In
December 1999, we entered into a Supply Agreement with Eagle-Picher
Technologies, LLC, for the right to purchase enriched silicon and carbon
isotopes from its facilities in Oklahoma. As described above, Eagle-Picher
failed to deliver the required silicon-28 to us in a timely manner, and we
have no assurance that it will be able to do so.

         We entered into a Supply Agreement, dated July 1996, with
Techsnabexport, a Russian government-based foreign trade organization, and an
isotope enrichment plant located in Siberia, Russia (the "Electro-Chemical
Plant" or "ECP"). The ECP is owned by the Ministry of Atomic Energy of the
Russian Federation, which is a cabinet post in the Russian Federation's
government. The Supply Agreement extends through 2001. Under the Supply
Agreement, the ECP will produce depleted zinc and other stable isotopes for
us, will allocate its stable isotope production capacity to us, and will
produce other stable isotopes in response to marketplace demand for those
isotopes. Under the Supply Agreement, the specific terms for each year's
production, including pricing terms, are negotiated between the parties by
November 1st of the preceding year. The agreement provides, among other
provisions:

         o        that the ECP will not sell depleted zinc to third parties
                  located in North America or to other parties for resale in
                  North America (this, and other associated sections of the
                  Supply Agreement have been assigned to Eagle-Picher effective
                  December 1, 1999);

         o        that as long as the ECP is able to meet all of our
                  requirements for depleted zinc at prices competitive with
                  other potential suppliers we will not buy depleted zinc from
                  other third parties located in the Russian Federation (this,
                  and other associated sections of the Supply Agreement have
                  been assigned to Eagle-Picher effective December 1, 1999); and

         o        that disputes arising under the Supply Agreement will be
                  resolved by arbitration conducted in Sweden under the
                  arbitration rules of the Stockholm Chamber of Commerce.


         The enforceability of the Supply Agreement might be subject to a
greater degree of uncertainty than if the Supply Agreement was with a United
States-based company, and the dispute(s), if any, were to be resolved in the
United States. Additionally, the supply of stable isotopes could be adversely
affected by changes in the political, economic, and military conditions in
Russia. Consequently, our operations could be materially and adversely
affected if: trade between Russia and the United States were interrupted or
curtailed; or we should fail to obtain and maintain all necessary Russian
Federation governmental approvals, and/or hostilities involving Russia should
occur.

         We have assigned the depleted zinc sections of this Supply Agreement
to Eagle-Picher and we no longer have any rights under those sections. We
have guaranteed performance by Techsnabexport and the ECP to Eagle-Picher.
This guarantee requires Eagle-Picher to pay us $500,000 each year, for three
years, if Techsnabexport and the ECP continue to honor the depleted zinc
sections of this Supply Agreement. We believe Techsnabexport has honored the
Supply Agreement as of the date of this prospectus; however, Eagle-Picher has
not yet paid the first installment of $500,000 due November 30, 2000, and we
have commenced our contractual dispute resolution process as a result of this
default.

         There can be no assurance that our relationship with the ECP and other
isotope producers in Russia will be



successfully maintained. Disruption or termination of our supply sources
could delay shipments by us and could have a material adverse effect on our
business, financial condition, and results of operations. We do not presently
maintain political risk insurance but we will evaluate the desirability and
availability of such insurance in the future. Operations in Russia, and
elsewhere within the former Soviet Union, entail certain other risks,
including, among others, supply disruptions as well as introduction of
tariffs and fluctuations in freight rates. SEE "RISK FACTORS."

         The ECP is one of four similar plants, which were designed to supply
the former Soviet Union, and certain other countries, with enriched uranium
(low enrichment for commercial nuclear power plant fuel, high enrichment for
military purposes). Following the accident at the nuclear power plant near
Chernobyl, Ukraine, in 1986, certain Russian nuclear power plants have been
shut down reducing the demand for uranium fuel. In the years since the
breakup of the former Soviet Union, beginning in 1989, the demand for uranium
for military purposes has also declined.

         In response to these trends, these processing plants, including the
ECP, have converted, or are considering converting, a portion of their
capacity to processing certain stable isotopes. We believe that additional
capacity could be converted to stable isotope production, if the processing
plants decided to do so. We also believe that these plants have the potential
capacity to meet all of our foreseeable needs for the processing of certain
stable isotopes. We believe that one or more of the other similar enrichment
plants may convert part of their capacity to the production of stable
isotopes should market demand increase substantially. To our knowledge no
other organization has a current contract with these facilities to produce
stable isotopes.

         Certain facilities elsewhere in the world, including the Oak Ridge
National Laboratory in Oak Ridge, Tennessee, and private and
pseudo-governmental facilities in Great Britain, Germany, The Netherlands,
and the Republic of South Africa, have the potential to produce stable
isotopes and, in certain cases, actually do produce these stable isotopes.

         To increase capacity, and to geographically diversify our production
of certain isotopes, on December 1, 1999, we entered into a Supply Agreement
with Eagle-Picher Technologies, LLC, for it to supply us with enriched stable
isotopes of silicon and carbon. We have already purchased 200 kilograms from
Eagle-Picher to be delivered during 2000. Eagle-Picher had expected to
produce these isotopes from its facilities in Oklahoma. There can be no
guarantee, however, that the facility will be able to produce high-purity
isotopes on commercially reasonable terms and, in fact, Eagle-Picher did not
deliver the 200 kilograms by December 31, 2000. We are in negotiations with
Eagle-Picher in regards to this and other related matters. We believe that
this relationship with Eagle-Picher may improve our profitability, and will
improve the security of our supply if the facility performs as expected.

         We have historically depended on a limited number of suppliers and
processors for certain manufacturing processes. Although we do have written
agreements with some of our suppliers and processors, we do not have any
written agreements with alternative suppliers and processors. We continue to
attempt to reduce our dependence on our suppliers, but disruption or
termination of any of the sources could occur, and such disruptions or
terminations could have at least a temporary, materially adverse, affect on
our business, financial condition, and results of operations. Moreover, a
prolonged inability to obtain alternative sources for processing could have a
materially adverse affect on our relations with our customers. Although our
relationship with Eagle-Picher has the potential to provide greater security
for our supply of silicon and carbon isotopes, if the facility performs as
expected, there can be no assurance that it will in fact do so.

GOVERNMENT REGULATION

         Regulation by government authorities in the United States and other
countries is a significant consideration in the development, production,
distribution, and marketing of our products; and in our continuing research,



development, and other activities. In order to clinically test, manufacture,
distribute, market, and sell products, especially those intended for
therapeutic or diagnostic use, mandatory procedures, and safety and other
standards established by applicable regulatory authorities must be followed.
In some cases, specific approval to clinically test and commercially
distribute such products must be obtained from numerous governmental
authorities. Furthermore, we are subject to various laws, regulations and
requirements relating to such matters as the import and export of our
products, ensuring safe working conditions, laboratory and manufacturing
practices, the use and disposal of hazardous or potentially hazardous
substances used in connection with our research, development and
manufacturing activities. Some of the regulations are summarized below.

FDA REGULATION

         We are not currently subject to any FDA regulation because we do not
currently manufacture any DBTs, drug products, or other medical devices. Our
customers may in many cases be subject to FDA regulation. If we, in the
future, test, manufacture, market, distribute, export, or sell diagnostic
products (such as any DBTs) or medical devices, we will also likely be
subject to extensive and rigorous regulation by the United States and other
countries in which we may choose to test, manufacture, or market our proposed
diagnostic products. As of the date of this prospectus, we have not
determined those specific countries, other than the United States, where we
might seek regulatory approvals to market any such products it may develop,
though we would likely seek such approval in certain European countries and
Japan. The products we intend to develop are subject to rigorous pre-clinical
and clinical testing and other FDA approval requirements, and similar
requirements in most other countries.

         There can be no assurance that any products developed by us, or
other entities to which we may sell bulk or other materials, will prove to
meet all of the applicable standards to receive marketing approval, or that
any such approvals will be granted on a timely basis, if at all, or that such
products if approved will be commercially successful. Delays and costs in
obtaining these regulatory approvals could adversely affect our ability to
commercialize our products and our ability to generate revenues. Even if
regulatory approvals for a product are obtained, such approvals may involve
restrictions and limitations on the labeling and clinical use of the product.
Following market approval, the product will continue to be subject to
compliance with applicable federal and state laws and regulations.

DIAGNOSTIC MEDICAL DEVICE PRODUCTS

         Certain of our contemplated diagnostic products may be regulated as
medical devices. Diagnostic products may be subject to one of two marketing
approval procedures. One procedure, known as a "510(k) review," is available
when the manufacturer can demonstrate that the proposed product is
"substantially equivalent" to another product that either was in commercial
distribution in the United States before May 28, 1976, or that has been
subsequently classified as a Class I or Class II medical device. When a
510(k) review is used, a sponsor is required to submit a Pre-Market
Notification to the FDA, at least 90 days before it plans to initiate
commercial distribution of the product.

         Where there is no existing legally marketed product "substantially
equivalent" to a contemplated product, the sponsor is required to seek
marketing approval of the product by a different process. This process, a
Pre-Market Approval ("PMA") application, involves a lengthier and more
burdensome procedure, which would likely require clinical studies. Together
with the FDA review of the PMA, this application process may take
three-to-five years before commercial marketing can occur, if the PMA is
approved. There can be no assurance that any future product we develop which
is subject to FDA review will be found to have an intended use and
characteristics that would qualify the product for commercial distribution
for clinical use under 510(k) Pre-Market Notification. Thus, PMAs may be
required for some or all of our future contemplated and proposed products.

         We have not developed any product that requires any clearance procedure
with the FDA, and no product is currently under active development. We believe
that any DBT instruments that we may develop in the future will



be eligible for marketing under a 510(k) Pre-Market Notification, if cleared
by FDA, but that the substrate would require approval of a New Drug
Application ("NDA"). We believe that clinical studies would be required to
obtain FDA approval of the 510(k)/NDA for the DBT instrument/substrate, and
would be conducted under an investigational device exemption ("IDE") approved
by the FDA. An IDE normally restricts the transfer of an investigational
device to a limited number of institutions, and use to a limited number of
investigators. There can be no assurances that FDA will allow us to conduct
such clinical studies or that such studies will provide the data necessary to
obtain the approval of the 510(k)/NDA for any DBT, or other product, that we
may develop, or that the FDA will in fact provide the necessary approval of
the 510(k)/NDA in a timely manner, if at all.

         In addition, use of DBTs and other diagnostic products that we may
develop may be subject to regulation under the Comprehensive Laboratory
Improvement Act of 1986 ("CLIA"). Under CLIA, clinical laboratories must be
certified to perform diagnostic tests. Such certification specifies the
highest "complexity level" of tests that the laboratory can perform. The
specific complexity level of a given diagnostic product is determined by
governmental agencies, currently the U.S. Centers for Disease Control. Our
ability to successfully market diagnostic products within the U.S. may depend
on our obtaining a complexity level determination that allows the broadest
use. There can be no assurance that such complexity level determination can
be obtained in a timely manner, if at all, and that such failure will not
have a material adverse effect on us, and our operations.

DRUG PRODUCTS

         We have not yet developed any drug products, as defined by the FDA,
and our research and development efforts for such products are only in the
very preliminary stages. The development and marketing of drugs is highly
regulated by the FDA. Certain products that we may develop may be classified,
depending on their characteristics, as drugs regulated under the FDA.
Development of a drug product for use in humans is a multi-step process.
First, laboratory and animal testing establish reasonable safety of the
experimental product for testing in humans, and suggest potential efficacy
with respect to a given disease. Once the general investigative plan and
protocols for specific human studies are developed, an investigational new
drug application is submitted to the FDA for approval. Once approved,
clinical investigations may commence.

         Following the successful completion of clinical trials, the clinical
evidence that has been accumulated is submitted to the FDA as part of a new
drug application. Approval of the NDA is necessary before a company may
market the product. The approval process can be very lengthy, frequently
taking one-to-two years, or more, after submission and depends in part upon
the speed of FDA's review of the application and the time required for the
company to provide satisfactory answers or additional clinical or other data
when requested. With any given product, there is no assurance that an NDA
will ever be approved in a timely manner, or at all. Failure to obtain such
approvals would prevent us from commercializing our products and would have a
material adverse effect on our business. Furthermore, the process of seeking
and obtaining FDA approval for a new product generally requires substantial
funding, and there can be no assurance such funding will be available.

CGMPS AND OTHER CONTROLS

         The FDA also has extensive regulations concerning manufacturing of
regulated products in accordance with current good manufacturing practices
("cGMPs"). If we commence the manufacture of any products subject to FDA
regulation (and we are not currently manufacturing any such products), we
will have to comply with cGMPs and we will have to ensure, compliance by our
third-party manufacturers. Continued compliance with cGMPs is required to
continue to market both drugs and medial devices once they are approved.
Failure to comply with the cGMP regulations or other applicable legal
requirements can lead to federal seizure of violating products, injunctive
relief actions brought by the federal government and potential criminal
investigation and prosecution of violators and its officers and employees who
are responsible for the activities that lead to the violations.

EXPORT AND ENVIRONMENTAL CONTROLS



         Certain of our products and technology, particularly those having
potential nuclear energy or military applications, such as depleted zinc and
related technology, are subject to stringent controls over their manufacture,
use, distribution, dissemination and export. In many cases, such activities
may require approvals or licenses from various U.S. and foreign governmental
agencies, and compliance with substantial regulatory controls. Such approvals
can be difficult to obtain and maintain and may not be obtainable from
certain countries. Furthermore, such approvals or licenses may be restricted
or terminated because of changes in laws, regulations, policies governing
those approvals and licenses, or changes in the political or other matters in
the countries granting such approvals or licenses to which our products and
technology would be exported.

         Likewise, certain of our current and potential operations may
necessitate submitting registrations or notifications to federal and state
regulatory authorities responsible for environmental and related matters,
including the U.S. Environmental Protection Agency ("EPA"). Additionally, we
are required to comply with stringent controls pertaining to the handling and
distribution of our products and operations, including under certain
conditions obtaining governmental approvals and licenses, either of which may
be subject to significant restrictions. Violation of any of these regulatory
controls may subject us to significant administrative civil and criminal
penalties, including loss of our approvals and licenses, or the imposition of
additional restrictions on our operations. There can be no assurances that we
will be able to obtain and maintain the approvals or licenses necessary to
successfully market our products and technology, or that it will be able to
comply with applicable laws and regulations. Any such failure to obtain such
licenses or approvals, where required, and comply with such laws and
regulations may materially and adversely affect our business, financial
condition and results of operations.

REGULATION OF NON-MEDICAL CHEMICAL PRODUCTS

         The import, export, handling, transportation, sale, storage and
other activities undertaken in connection with our non-medical products are
subject, or potentially subject, to substantial federal, state, local and
foreign government controls pertaining to hazardous chemical and chemical
wastes, import export controls and other matters. These regulations are
complex, pervasive, and constantly evolving. Our ability to effect and
maintain compliance with these controls is important to our commercial
success.

         With respect to transportation of our products, we rely
predominantly on Russian and U.S. freight carriers to handle and deliver all
our shipments, and utilize domestic overnight courier services for shipments
to our customers. These carriers must comply with Department of
Transportation ("DOT") regulations in the shipping and packaging of the
stable isotope chemicals. We must also comply with DOT regulations when
packaging material kept in inventory for domestic shipment. As required under
federal and state law, we have prepared Material Safety Data Sheets ("MSDS"),
which are enclosed with each product shipment. We must periodically update
our MSDS sheets based on new literature reports. We cannot assure that our
MSDS sheets will continue to be in compliance with applicable requirements.

         The shipments received at our Columbia, Maryland facility are
subject to Federal and Maryland regulations pertaining to hazardous chemicals
and hazardous waste disposal. These shipments are stored in an area of the
facility designated for such materials. Currently, we are considered a small
quantity generator of hazardous waste and will rely on certified haulers to
dispose of our minimal amounts of hazardous waste. We believe we are in
compliance, in all material respects, with applicable federal and state
environmental regulatory requirements.

         Should the levels of hazardous waste increase as our inventory and
handling operations increase in volume, we would have to comply with
Environmental Protection Agency ("EPA") requirements and obtain an EPA ID
number. However, this is not currently necessary.

         The shipments from Russian manufacturing sources now enter the U.S.
duty free (without tariff); however, there can be no assurance that such
duty-free importation will continue. If the shipments are subject to tariff, we



cannot assure that we will be able to sell the imported products or that the
products will be commercially viable because of these increased tariff costs.

         The Nuclear Regulatory Commission ("NRC") has authority to regulate
importation and exports of deuterium containing chemicals whose ratio of
deuterium atoms to hydrogen atoms exceed 1:5,000. At present, the deuterium
containing compounds that we import do not require any special licenses or
importation authorization. However, there can be no assurances that the NRC
will continue these policies. The NRC regulates exports of deuterium
containing chemicals under general license. We will not be able to ship these
chemicals to certain countries that require a special license for such
shipments; none of these countries represent significant current or expected
future markets for our anticipated and present products. In addition, certain
technology or products that we have or may in the future develop, may be
subject to other government controls pertaining to armaments, including the
need to obtain special licenses for exports. The imposition of such controls
may impair our ability to broadly market such products.

         Our facilities and employees are also required to comply with
environmental and other regulations concerning the operations of and the
materials we use, as well as handling and distribution of products and waste
materials. Failure to ensure compliance with such federal, state, or local
laws and regulations could have a material adverse effect on us.

         In addition, the manufacture, distribution and export of some of our
current or potential products and technology may be subject to governmental
controls pertaining to materials and technology that might have been used for
military, nuclear power, or nuclear weapons purposes. These controls include,
in certain cases, export license requirements or other restrictions. There
can be no assurances that we will be able to obtain or maintain such
licenses, or that the failure to obtain or maintain such licenses, or comply
with other restrictions that might be placed on such manufacturing and
exports, will not have a material adverse effect on us and our operations.

PRODUCT LIABILITY AND INSURANCE

         Our business exposes us to potentially substantial product,
environmental, occupational, and other liability risks, which are inherent in
product research and development, manufacturing, marketing, distribution, and
use of our products and operations, including, but not limited to, products
used in nuclear power plants and medical device products. We have product
liability insurance in order to protect ourselves from such potential
exposures. There can be no assurance that adequate insurance coverage will be
available at an acceptable cost, if at all, or, a product liability or other
claim would not materially and adversely affect our business or financial
condition. The terms of our agreements with our customers provide that
liability is limited to our standard warranty to replace non-conforming
product, and liability for consequential damages caused by the improper use
of our products is limited by contractual terms. Nevertheless, one or more
third parties could bring action against us based on product liability,
breach of warranty, or other claims, and, there can be no assurance that the
foregoing contract clauses would effectively limit our liability in any such
actions.

EMPLOYEES

         As of January 1, 2001, we had 30 full and part-time employees, of
whom eight have Ph.D.s in scientific or engineering disciplines.
Approximately eleven employees are involved in research and product
development, five in manufacturing and sourcing, and fourteen in business
development and administration, but such employees' responsibilities may also
encompass areas other than their primary area of responsibility. We consider
our relations with our employees to be good. None of our employees are
covered by a collective bargaining agreement.

PROPERTIES



         We relocated our headquarters to Golden, Colorado in December 1998,
and now share facilities with our wholly-owned subsidiary, Interpro. Interpro
leases approximately 41,000 square feet of office, research, and production
facilities. The lease expires in June 2001. The facility is used for our zinc
recovery and recycling research and development project, silicon-28 materials
processing, as well as corporate administration. We also sub-let space and
facilities to contract research, development, and materials processing
entities.

         We lease 1,750 square feet for an administrative sales office in
Columbia, Maryland that expires December 1, 2003. Chemotrade leases office
space in Dusseldorf and Leipzig, Germany. IUT leases production and
administration facilities in Berlin, Germany.

LEGAL PROCEEDINGS

         We are not subject to any pending or, to our knowledge, threatened,
legal proceedings except litigation we instituted against International
Isotopes, Inc. in the United States District Court for the District of
Colorado for the collection of approximately $280,000 we believe it owes us
for product we have sold to and delivered to International Isotopes, Inc.
This litigation is in the preliminary stages and we have only recently
received the answer filed by International Isotopes, Inc. in which it denied
all of our material allegations and contested the jurisdiction of the
Colorado court.

CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL
DISCLOSURE

         None.



                                 MANAGEMENT

IDENTIFICATION OF DIRECTORS AND EXECUTIVE OFFICERS

         The following table sets forth the names and ages of all the Directors
and Executive Officers of Isonics, and the positions held by each such person as
of January 1, 2001. Each of the directors holds office until the next annual
meeting of shareholders and until his or her successor is elected and qualified
or until his or her earlier death, resignation, or removal. Each officer serves
at the discretion of the Board.



NAME                                         AGE POSITION
- ----                                         --- --------
                                           
James E. Alexander                           51  President, Chief Executive Officer and Chairman of the Board
Boris Rubizhevsky                            50  Senior Vice President, Vice Chairman and Director
Daniel J. Grady                              46  Vice President, Life Sciences
Stephen J. Burden                            52  Vice President, Semiconductor Materials
Brantley J. Halstead                         43  Chief Financial Officer, Vice President, Finance
Robert Cuttriss                              51  President of Interpro, Vice President, Zinc Recovery
Herbert Hegener                              53  Managing Director of Chemotrade
Lindsay A. Gardner (1)(2)                    49  Director
Richard Parker (1)(2)                        57  Director
Larry J. Wells (1)(2)                        57  Director


- -----------

(1)      Member of the Compensation Committee.

(2)      Member of the Audit Committee.


         Mr. Alexander is our co-founder and has served as our President, Chief
Executive Officer and a director since our inception. He has worked full-time
for Isonics since January 1994. From June 1972 to December 1993, he worked in a
variety of technology positions at General Electric Corporation ("GE") in the
aircraft engine and nuclear power businesses, where his last position was
Manager of Technology Programs. Mr. Alexander received his Bachelors degree in
Metallurgical Engineering from the University of Cincinnati and performed
graduate work in materials science there. He earned a Masters degree in Business
Administration from Santa Clara University.

         Mr. Rubizhevsky is also a co-founder of Isonics and has been a Senior
Vice President and a director since inception and became Vice Chairman in March
1997. From November 1986 through December 1994, he owned and operated SAR
Marketing, a consulting firm providing business advice and services to large
multinational corporations. From June 1977 to May 1986, Mr. Rubizhevsky worked
at General Electric Corporation as Business Development Manager in various
international locations. He received his Bachelors degree in Engineering from
Stevens Institute of Technology.

         Dr. Grady joined us as Vice President, Medical, Research and
Diagnostics in 1995. From March 1994 through September 1995, Dr. Grady was Vice
President of Research and Development at Sopha Medical Systems, a medical
diagnostic imaging equipment manufacturer. From April 1991 until March 1994, he
served as Marketing Manager, Nuclear Energy for General Electric Corporation
("GE"). From May 1988 through March



1991, Dr. Grady served as Software Engineer Manager, Nuclear Medicine for GE
in England. From October 1984 through May 1988, he served as Clinical
Applications Manager for GE Nuclear Medicine. Between June 1981 and October
1984, he served as Engineering Analysis Section Head for TRW. Dr. Grady
received his Bachelors and Masters degrees, and Ph.D. in Nuclear Engineering
from the University of Michigan.

         Dr. Burden joined us in 1997 as Director of Research & Development and
was promoted to Vice President, Semiconductor Materials effective January 1,
1999. Prior to joining Isonics, Dr. Burden was Director of Product Development
at sp3, Inc., a manufacturer of diamond-coated tools. From 1984 to 1993, he was
Manager of Advanced Materials R&D at GTE Valenite, a subsidiary of GTE
Corporation, a manufacturer of cutting tools. From 1974 to 1984, Dr. Burden was
employed by General Electric Corporation in various capacities. Dr. Burden
received his Ph.D., and Masters of Science degrees, in Materials Science and
Engineering, from Drexel University, and his Bachelors degree in Science
Engineering from Northwestern University. Dr. Burden also has an MBA from the
University of Michigan.

         Mr. Halstead joined us as Chief Financial Officer in 1999 and was
promoted to Vice President, Finance effective January 30, 2000. Most recently,
Mr. Halstead was Chief Financial Officer of Bio-Medical Automation, Inc.
(formerly OZO Diversified Automation, Inc.), from 1997 through 1999. Mr.
Halstead also has nine years of management consulting experience, including five
years with Deloitte & Touche LLP. Prior to earning his Masters of Business
Administration in Finance from the University of Denver, Mr. Halstead worked as
a metallurgical engineer. Mr. Halstead received his Bachelors degree in
Metallurgical Engineering from the Colorado School of Mines, and his Masters of
Accountancy from the University of Denver.

         Dr. Cuttriss has served as the President of Interpro since 1993. Since
May 2000, Dr. Cuttriss has also served as Vice President, Zinc Recovery. With 29
years experience in process operations in the mining and metallurgical
industries, Dr. Cuttriss' experience includes holding the title of principal
consultant and director of Metallurgy International, Inc., from 1983 through
1993. He has undertaken management and technical assignments covering the
design, commissioning and operation of mineral treatment plants, technical
audits and evaluations, pilot plant testing and process development for projects
throughout the world. Dr. Cuttriss received his Bachelors and Ph.D. degrees in
Metallurgy from the University of Melbourne and his Masters in Metallurgy from
the University of Queensland.

         Mr. Hegener is a co-founder of Chemotrade and has served as the
President since its formation in 1991. From 1988 to 1991, Mr. Hegener was with
Medgenix Deutschland GmbH-Dusseldorf, Germany, and his last position with this
firm was Managing Director. From 1973 to 1988, Mr. Hegener worked at the Hempel
Group, Dusseldorf, Germany, in various management positions. Mr. Hegener is a
specialist in stable and radioactive isotopes. He has degrees in Chemistry and
Economics.

         Ms. Gardner was elected a director in September 1993. Ms. Gardner has
served from 1991 through the present as President of LG Associates, a
U.S.-based, management consulting firm providing materials management expertise
to foreign company affiliates of U.S. companies in developing countries. During
her tenure at LG Associates Ms. Gardner resided in Moscow, Russia from September
1991 to January 1994, when she moved to Beijing, China. As of April 2000, Ms.
Gardner resides in Cincinnati, Ohio. From 1977 to 1991, Ms. Gardner worked for
General Electric Corporation in a variety of management and functional positions
including international marketing, quality assurance, and materials management.
Ms. Gardner received a Bachelors degree in International Economics from The
George Washington University Elliott School of International Affairs, and earned
a Masters of Business Administration from the University of Louisville.

         Mr. Parker has served as a director since August 1998. Mr. Parker is
presently Vice-President of Distribution Sales for Cypress Semiconductor and has
held that position since December 1997. Previously, Mr. Parker was Director of
Sales for Cypress from April 1984 to December 1997. Prior to joining Cypress, he
held various sales and marketing management positions at Fairchild Semiconductor
from 1973 to 1984. He received a



Bachelors degree in Education from the University of North Dakota.

         Mr. Wells was elected a director of Isonics in January 2000. Since
1989, Mr. Wells has been a general partner of SVP Management Company, the
management company for Sundance Venture Partners, L.P., a venture capital fund.
From 1983 to 1989, Mr. Wells served as Vice President of Citicorp Venture
Capital then became Senior Vice President of Inco Venture Capital. Mr. Wells is
a director of Cellegy Pharmaceuticals, Identix, Inc., as well as several
privately held companies. Mr. Wells received his Bachelors degree in Economics
and earned a masters degree in Business Administration from Stanford University.
Mr. Wells was previously a director of Isonics from September 1996 through
December 1998.

         There are no significant employees who are not also directors or
executive officers as described above. As of April 30, 2000, and subsequently,
there were and are no family relationships among the officers, directors or any
person chosen by the Company to become a director or officer. No arrangement
exists between any of the above officers and directors pursuant to which any one
of those persons was elected to such office or position.



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND MANAGEMENT


         The following table sets forth certain information regarding the
ownership of the our Common Stock as of January 17, 2001, by: (i) each nominee
for director; (ii) each of the executive officers named in the Summary
Compensation Table; (iii) all executive officers and directors of the Company as
a group; and (iv) all those known by us to be beneficial owners of more than
five percent of our Common Stock.



                                                     BENEFICIAL OWNERSHIP
                                                     --------------------
BENEFICIAL OWNER                               NUMBER OF SHARES        PERCENT OF TOTAL
- ---------------                                ----------------        ----------------
                                                                 
James E. Alexander (1)                             2,076,779                   17.3%
Boris Rubizhevsky (2)                              1,828,293                   15.2%
Stephen J. Burden (3)                                289,880                    2.4%
Daniel J. Grady (4)                                  243,309                    2.0%
Brantley J. Halstead (5)                             141,000                    1.2%
Robert H. Cuttriss (6)                               307,982                    2.6%
Herbert Hegener (7)                                   80,644                    0.7%
Lindsay Gardner (8)                                  299,761                    2.5%
Richard Parker (9)                                    50,000                    0.4%
Larry Wells (10)                                     117,241                    1.0%
All executive officers and directors as a
    group (10 persons).  The address for all       5,434,889                   42.4%
    of the above directors and executives
    officers is:
   5906 McIntyre Street, Golden, CO 80403
Richard Grossman (11)                              1,873,336                   15.6%
Anfel Trading (12)                                   666,668                    5.4%
Eagle-Picher Technologies, LLC (13)                3,130,435                   26.1%


- -----------

(1)      Includes (i) 25,000 shares of Common Stock underlying options which are
         currently exercisable, (ii) 45,455 shares of Common Stock held in the
         name of The James & Carol Alexander Family Foundation, and (iii)
         500,000 shares held by wife Carol, (iv) 4,000 shares held by son
         Benjamin Alexander, and (v) 4,000 shares held by son Jonathan
         Alexander.



(2)      Includes (i) 1,731,127 shares of Common Stock held jointly with Mr.
         Rubizhevsky's wife, (ii) 22,500 shares of Common Stock underlying
         options which are currently exercisable, and (iii) 33,333 shares of
         Common Stock underlying 33,333 warrants to purchase Common Stock of
         Isonics, (iv) 33,333 shares of Common Stock held by wife Nancy Eiden
         Rubizhevsky, (v) 4,000 shares of Common Stock held by son Zachary
         Rubizhevsky, and (vi) 4,000 shares of Common Stock held by son Ryan
         Rubizhevsky.

(3)      Includes 192,887 shares of Common Stock underlying options of which
         130,025 have vested as of December 31, 2000, and which are currently
         exercisable.

(4)      Includes 222,965 shares of Common Stock subject to stock options that
         are currently exercisable.

(5)      Includes 125,000 shares of Common Stock underlying options of which
         80,000 have vested as of December 31, 2000, and which are currently
         exercisable.

(6)      Includes (i) 287,982 shares of Common Stock held in the name of
         Metallurgy International, Inc., in which Dr. Cuttriss and his wife, P.
         D. Cuttriss, are controlling shareholders, and (ii) 20,000 shares of
         Common Stock underlying options that are currently exercisable.

(7)      Includes 35,000 shares of Common Stock underlying warrants, which are
         currently exercisable.

(8)      Includes 50,000 shares of Common Stock underlying stock options, which
         are currently exercisable.

(9)      Includes 50,000 shares of Common Stock underlying stock options, which
         are currently exercisable.

(10)     Includes 40,000 shares of Common Stock underlying stock options, which
         are currently exercisable. Also includes 77,241 shares owned by Daystar
         Partners, L.P. of which an affiliate owned by Mr. Wells is general
         partner, and in which Mr. Wells owns a 9.9% equity interest.

(11)     Includes beneficial ownership of the following shares: (i) 40,000
         shares of Common Stock underlying 20,000 shares of Series A Preferred
         Stock and 20,000 warrants owned of record and beneficially by Richard
         Grossman, (ii) 40,000 shares of Common Stock underlying 20,000 shares
         of Series A Preferred Stock and 20,000 warrants owned of record and
         beneficially by Orin Hirschman (of which shares Mr. Grossman disclaims
         beneficial ownership), (iii) 1,106,668 shares of Common Stock
         underlying 553,334 shares of Series A Preferred Stock and 553,334
         warrants owned of record and beneficially by Adam Smith Investment
         Partners, L.P., (iv) 226,668 shares of Common Stock underlying 113,334
         shares of Series A Preferred Stock and 113,334 warrants owned of record
         and beneficially by Adam Smith Investments, Ltd., and (v) 500,000
         shares of Common Stock underlying 500,000 warrants owned of record and
         beneficially by Adam Smith & Company, Inc., all as set forth on the
         Schedule 13D filed by such persons on August 12, 1999. The business
         addresses of Richard Grossman and Orin Hirschman, and the principal
         executive offices of Adam Smith Investment Partners, L.P. and Adam
         Smith & Company, Inc., are located at 101 East 52nd Street, New York,
         New York 10022. The principal executive offices of Adam Smith
         Investments, Ltd. are c/o Insinger Fund Administration (BVI) Limited,
         Tropic Isle Building, P.O. Box 438, Road Town, Tortola, British Virgin
         Islands.

(12)     Includes 333,334 shares of Common Stock underlying 333,334 warrants.
         The principal executive offices of Anfel Trading Ltd. are c/o Me. Andre
         Zolty, 24 Route De Malagnou, 1208 Geneva, Switzerland.

(13)     This share ownership results from Eagle-Picher's exercise of a warrant
         to purchase 4,000,000 shares of our Common Stock at $3.75 per share,
         which resulted in Eagle-Picher acquiring 3,130,435 shares upon
         surrender of the warrant. (Eagle-Picher has not accepted our
         calculation of the number of shares owed, and



         claims that an additional 155,279 may be due. Furthermore
         Eagle-Picher did not meet its contractual obligation to deliver 200
         kilograms of silicon-28 to us by December 31, 2000. We believe that
         we may have the right to cancel all of these shares and we have so
         advised Eagle-Picher. We are continuing to discuss these and other
         related matters with Eagle-Picher.) The principal executive offices
         of Eagle-Picher Technologies, LLC are located at 250 East Fifth
         Street, Suite 500, Cincinnati, Ohio 45202.

         The Series A Convertible Preferred Stock ("Series A Preferred Stock")
consists of 1,830,000 shares issued with a liquidation preference and conversion
right of $1.50 per share. Through December 31, 2000, 649,667 shares of Series A
Preferred Stock have elected to convert into Common Stock. The Series A
Preferred Stock is entitled to dividends or distributions equal to the amount of
the dividend or distribution per share of Common Stock payable at such time
multiplied by the number of shares of Common Stock then obtainable upon
conversion of such Series A Preferred Stock. The Redemption Trigger Date for the
Series A Preferred Stock shall be the business day immediately following the
thirtieth consecutive trading day that the average closing price during such
trading days (or, if no closing price is reported, the average of the bid and
ask prices) of the shares of Common Stock was above $8.00 per share (which
minimum price shall be proportionally adjusted for stock splits, stock
dividends, reverse stock splits and any other subdivision or combination of the
Common Stock). After the Redemption Date, the Company may redeem all or any part
of the Series A Preferred Stock at its election at any time and from time to
time. The Series A Preferred Stock is convertible into Common Stock at the
option of the holder until the Company, if at all, chooses to redeem such shares
on the basis of one share of Common Stock per share of Series A Preferred Stock
and, until converted, each share of Series A Preferred Stock is entitled to one
vote at any meeting of the shareholders of the Company.

         The Company knows of no arrangement, the operation of which may, at a
subsequent date, result in change in control of the Company.


              SECTION 16(b) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

SECTION 16(b) DISCLOSURE

         Section 16(a) of the Securities Exchange Act of 1934 (the "1934 Act")
requires Isonics' directors, executive officers and persons who own more than
ten percent of a registered class of Isonics' equity securities, to file with
the SEC initial reports of ownership and reports of changes in ownership of
Common Stock and other equity securities of Isonics. Officers, directors and
greater than ten percent shareholders are required by SEC regulation to furnish
Isonics with copies of all Section 16(a) forms they file.

         To our knowledge, based solely on a review of the copies of such
reports furnished to our and written representations that no other reports were
required, during the fiscal year ended April 30, 2000, and subsequently, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than ten percent beneficial owners were complied with exception (or in
addition) to the following:

1.       Mr. Rubizhevsky filed a Form 4 in February 2000, reporting a purchase
         that took place in July 1999. Mr. Rubizhevsky also filed a Form 4 after
         April 10, 2000 to report a sale of 1,000 shares made in March 2000.

2.       Mr. Parker filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became a director of
         Isonics in August 1998.

3.       Dr. Cuttriss and his affiliate, Metallurgy International, Inc., jointly
         filed a Form 3 in February 2000. Dr. Cuttriss became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in May 1998. A joint filing of two Form 4s was also
         made in February 2000 reporting transactions that occurred in July 1999
         and September 1999, which Dr. Cuttriss amended in May 2000.



4.       Mr. Halstead filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in March 1999.

5.       Dr. Burden filed a Form 3 in February 2000. He became subject to the
         Section 16(a) reporting requirements when he became an executive
         officer of Isonics in January 1999. Dr. Burden also filed a Form 4 in
         February 2000 reporting a purchase that took place in July 1999. Dr.
         Burden filed a Form 4 after April 10, 2000, reporting an exercise of
         warrants that occurred in March 2000.

6.       Mr. Herbert Hegener filed a Form 3 in February 2000. He became subject
         to the Section 16(a) reporting requirements when he became an executive
         officer of Isonics' subsidiary, Chemotrade, Inc., in June 1998. Mr.
         Hegener filed a Form 4 in February 2000, reporting a warrant acquired
         in June 1999. Mr. Hegener also filed Forms 4 in August 2000 reporting
         sales that took place in May, June, and July of 2000.

7.       Eagle-Picher Technologies, LLC became subject to the Section 16(a)
         reporting requirements when it became a greater than 10% beneficial
         owner in December 1999. Eagle Picher filed a Form 3 in March 2000.
         Eagle-Picher exercised warrants in March 2000 but, to our knowledge has
         not yet filed a Form 4 reporting the exercise; Eagle-Picher has also
         not yet filed an amendment to its Schedule 13D reporting this exercise.

8.       Mr. Paul J. Catuna, Jr., a former executive officer of Isonics, was
         subject to the reporting requirements of Section 16(a) of the 1934 Act
         during the course of his employment. Mr. Catuna has filed a Form 4 in
         February 2000, reporting a stock bonus received in January 1999. Mr.
         Catuna is no longer subject to the reporting requirement of Section
         16(a).

9.       Mr. Wells filed a Form 4 after April 10, 2000, reporting that an
         affiliated entity exercised warrants in March 2000.

10.      Ms. Gardner filed a Form 4 in May 2000, reporting the exercise of
         warrants in March 2000.

11.      Mr. Alexander filed a Form 4 after July 10, 2000, reporting a sale of
         536,000 shares in June 2000.


         In addition to the foregoing, several directors and executive officers
filed Form 4s in February 2000, which voluntarily reported the acquisition of
certain Common Stock options that are exempt from the reporting requirements
pursuant to Rule 16b-3.

(a)      Mr. Alexander voluntarily filed three Form 4s in February 2000,
         reporting transactions that took place in January, April, and December
         of 1999. The Board of Directors approved the January and April
         transactions in minutes effective October 31, 1999.

(b)      Mr. Rubizhevsky voluntarily filed two Form 4s in February 2000,
         reporting transactions that took place in January and April 1999. The
         Board of Directors approved the January and April transactions in
         minutes effective October 31, 1999.

(c)      Ms. Gardner voluntarily filed one Form 4 in February 2000, reporting
         transactions that took place in May and October 1998.

(d)      Mr. Parker voluntarily filed a Form 4 in February 2000, reporting
         transactions that occurred in October 1998.



(e)      Mr. Halstead voluntarily filed two Form 4s in February 2000, reporting
         transactions that took place in April 1999 and in January 2000. The
         Board of Directors approved these transactions in minutes effective
         October 31, 1999, and January 30, 2000.

(f)      Dr. Burden voluntarily filed one Form 4 in February 2000, reporting a
         transaction that took place in April 1999. The Board of Directors
         approved this transaction in minutes effective October 31, 1999.

(g)      Dr. Grady voluntarily filed two Form 4s in February 2000, reporting
         transactions that took place in January and April 1999, and were
         approved by the Board of Directors in minutes effective October 31,
         1999.


SHORT-SWING LIABILITY

         On behalf of Metallurgy International, Inc., an affiliate of Dr.
Cuttriss, but without authorization from Dr. Cuttriss or Isonics, a
broker-dealer sold and purchased shares in July and September 1999,
respectively. With authorization from Dr. Cuttriss and Isonics, Metallurgy
International, Inc. sold additional shares in February and March 2000. As a
result, Isonics raised the concern that Dr. Cuttriss may have obtained a
short-swing profit which Dr. Cuttriss satisfied, subject to further review after
consultation with his personal counsel. Isonics has received an opinion of
counsel, which reached the conclusion that "a court would likely not impose
liability on [Dr.] Cuttriss for the unauthorized July 1999 and September 1999
transactions under Section 16(b) of the Securities Exchange Act of 1934."


                       EXECUTIVE COMPENSATION


SUMMARY COMPENSATION TABLE

         The following table sets forth information regarding compensation
awarded, paid to, or earned by the chief executive officer and the other
principal officers of Isonics for the three years ended April 30, 1998, 1999,
and 2000. No other person who is currently an executive officer of Isonics
earned salary and bonus compensation exceeding $100,000 during any of those
years. This includes all compensation paid to each by Isonics and any
subsidiary.


                                                                                                 LONG-TERM
                                               ANNUAL COMPENSATION                         COMPENSATION AWARDS
                                               -------------------                         -------------------
                                                                                          AWARDS           PAYOUT
                                                                                          ------           ------
                                                                               ($)       SECURITIES
                             FISCAL       ($)        ($)        ($)        RESTRICTED    UNDERLYING         LTIP      ALL OTHER
NAME AND PRINCIPAL POSITION   YEAR      SALARY      BONUS     OTHER(a)       AWARDS   OPTIONS & SARS (#)   PAYOUT    COMPENSATION
- ---------------------------  ------     ------      -----     --------     ---------- -----------------    ------    ------------
                                                                                             
James E. Alexander             1998     204,870            0    60,553(g)          0               0           0           0
President & CEO                1999     200,000       50,000    35,016(g)          0       25,000(k)           0           0
                               2000     212,000   172,549(e)    39,280(h)          0               0           0           0
Boris Rubizhevsky              1998     176,975            0    25,946(g)          0               0           0           0
Senior Vice President          1999     184,100       45,000    25,404(g)          0       22,500(l)           0           0
                               2000     191,000   147,670(f)    28,185(i)          0               0           0           0
Daniel J. Grady                1998     125,603            0            0          0               0           0           0
Vice President                 1999     127,188       16,000            0          0       15,625(m)           0           0
                               2000     125,000       10,271    23,833(j)          0               0           0           0
Stephen J. Burden,             1998         N/A          N/A          N/A        N/A             N/A         N/A         N/A
Vice President (b)             1999           0            0            0          0      121,458(n)           0           0
                               2000     125,000            0       23,452          0               0           0           0


Robert H. Cuttriss             1998         N/A          N/A          N/A        N/A             N/A         N/A         N/A
President of Interpro (c)      1999      92,872       80,000            0          0       20,000(o)           0           0
                               2000     104,815            0        3,144          0               0           0           0
Brantley J. Halstead,          1998         N/A          N/A          N/A        N/A             N/A         N/A         N/A
Vice President (d)             1999      22,182            0            0          0      116,000(p)           0           0
                               2000     102,000       16,000        3,870          0       25,000(q)           0           0


- -----------

(a)      Excludes other compensation, the aggregate amount of which does not
         exceed the lesser of $50,000 or 10% of such named Executive Officers'
         annual compensation.

(b)      Dr. Burden became an officer of Isonics effective January 1999.

(c)      Interpro was acquired effective April 30, 1998. Prior to May 1, 1998,
         Dr. Cuttriss was not an Isonics employee. The bonus paid to Dr.
         Cuttriss in fiscal year 1999 was for back pay accrued prior to the
         acquisition of Interpro by Isonics.

(d)      Mr. Halstead became an officer of Isonics in February 1999, upon his
         joining the Company as Chief Financial Officer. Mr. Halstead was
         promoted to Vice President, Finance in January 2000.

(e)      Mr. Alexander's amount includes $133,451 for forgiveness of a loan owed
         to the Company, and $39,098 to pay applicable payroll taxes on a stock
         bonus granted in January 1999. Please see "CORPORATE LOANS TO
         OFFICERS."

(f)      Mr. Rubizhevsky's amount includes $113,598 for forgiveness of a loan
         owed to the Company, and $29,072 to pay applicable taxes on stock bonus
         granted in January 1999, and a $5,000 additional cash bonus. Please see
         "CORPORATE LOANS TO OFFICERS."

(g)      Mr. Alexander's amounts represent $35,016 for interest and taxes
         payable as a result of a loan in fiscal year 1999, and $60,553 for
         interest and taxes payable as a result of a loan in fiscal year 1998.
         Mr. Rubizhevsky's amounts represent $25,404 for interest and taxes
         payable as a result of a loan in fiscal year 1999, and $25,946 for
         interest and taxes payable as a result of a loan in fiscal year 1998.

(h)      Mr. Alexander's amount includes $26,543 for accrued vacation that was
         paid in December 1999, $9,487 car allowance, and $3,250 employer
         matching contribution to the Company's 401k plan.

(i)      Mr. Rubizhevsky's amount includes $15,005 for accrued vacation that was
         paid in December 1999, $9,000 car allowance, and $4,180 employer
         matching contribution to the Company's 401k plan.

(j)      Dr. Grady's amount includes $12,020 for accrued vacation that was paid
         in December 1999, $9,000 car allowance, and $2,813 employer matching
         contribution to the Company's 401k plan.

(k)      Options to purchase 25,000 shares of Common Stock were granted in April
         1999, as consideration for delaying salary in March and April 1999, and
         are currently exercisable at $1.4375 per share and expire April 26,
         2004.

(l)      Options to purchase 22,500 shares of Common Stock were granted in April
         1999, as consideration for delaying salary in March and April 1999, and
         are currently exercisable at $1.4375 per share and expire




         April 26, 2004.

(m)      Options to purchase 15,625 shares of Common Stock were granted in April
         1999, as consideration for delaying salary in March and April 1999, and
         are currently exercisable at $1.4375 per share and expire April 26,
         2004.

(n)      Options to purchase 100,000 shares of Common Stock were granted in
         January 1999 as consideration for Dr. Burden's promotion to vice
         president in January 1999, with an exercise price of $1.10 per share
         (of which 50,000 have vested as of August 30, 2000, and continue to
         vest at a rate of 5%, or 5,000, per quarter). Options to purchase
         21,458 shares of Common Stock were granted in April 1999 as
         consideration for delaying salary in March and April 1999, and are
         currently exercisable at $1.4375 per share and expire April 26, 2004.

(o)      Options granted in May 1998 in connection with the acquisition of
         Interpro by Isonics are currently exercisable at $2.00 per share and
         expire May 1, 2003.

(p)      Options to purchase 100,000 shares of Common Stock were granted in
         February 1999, as consideration for Mr. Halstead joining the Company as
         Chief Financial Officer, with an exercise price of $2.5625 per share
         (of which 55,000 have vested as of December 31, 2000, and continue to
         vest at a rate of 5%, or 5,000, per quarter). Options to purchase
         16,000 shares of Common Stock were granted in April 1999, as
         consideration for delaying salary in March and April 1999, and are
         currently exercisable at $1.4375 per share and expire April 26, 2004.
         Mr. Halstead exercised these options in October 2000 for cash.

(q)      Options to purchase 25,000 shares of Common Stock were granted in
         January 2000, as consideration for Mr. Halstead's promotion to Vice
         President in January 2000, with an exercise price of $7.3125 per share.


         In October 1996, we adopted an employee benefit plan under Internal
Revenue Code Section 401(k). The 401(k) plan is a profit sharing plan under
which both employees and Isonics are entitled (at their own discretion) to
contribute a portion of compensation and earnings, respectively, to investment
funds to supplement employee retirement benefits. On November 1, 1999, the
Isonics Corporation 401(k) plan was merged with the Interpro 401(k) plan.

         We do not have written plans to pay bonuses or deferred compensation to
our employees except those expressly stated in the following sections.

         We have adopted medical, dental, and life insurance plans for our
employees and their dependents at our cost. In some cases, we also provide
discretionary disability and other insurance plans for the benefit of our
employees.


EMPLOYMENT AGREEMENTS, TERMINATION OF EMPLOYMENT AND CHANGE IN CONTROL
AGREEMENTS

         In September 1997, we entered into employment agreements with James E.
Alexander and Boris Rubizhevsky. The agreements have a term of four years and
provide for annual salaries of $200,000 and $180,000, respectively, although
either Isonics or the individuals may terminate these agreements prematurely in
their discretion. By resolution of the Board made on January 30, 2000, both Mr.
Alexander and Mr. Rubizhevsky received salary increases commencing February 1,
2000, equal to 20% of their current salary, $240,000, and $216,000,
respectively. The salary increases were granted in recognition of their
performance for Isonics and the fact that neither Mr. Alexander nor Mr.
Rubizhevsky had received salary increases in approximately two and one-half
years. Under the agreements, each officer is entitled to receive incentive
compensation up to 50% of the



officer's annual salary, as we approve, pursuant to such executive
compensation plan as we may approve. The agreements provide that upon a
termination of employment other than for cause (as defined in the
agreements), the officer is entitled to severance compensation of eighteen
(18) months of his salary, paid at the same time as salary payments, 25% of
the officer's annual prevailing salary, paid upon termination, and in
addition all outstanding stock options held by the officer will be
accelerated and will become exercisable in full and our right of repurchase
will terminate with respect to such shares. The agreements provide for
similar accelerated vesting of outstanding stock options upon a change in
control of Isonics.

         We have also entered into employment agreements with Dr. Daniel J.
Grady and Dr. Stephen J. Burden. The agreements have an indefinite term and
provides for at-will employment, terminable at any time by either party. The
agreements provide for a rate of annual compensation, which we will review
annually. Under each agreement, Dr. Grady and Dr. Burden are entitled to
participate in our standard plans and policies. The agreements also include
confidentiality and invention assignment provisions. Additionally, Mr. Herbert
Hegener and Dr. Robert Cuttriss are covered by employment agreements extending
through the September 2001, and September 2003, respectively.

         Mr. Brantley J. Halstead was hired as Chief Financial Officer in
February 1999. Mr. Halstead has entered into an employment agreement with us.
The agreement has an indefinite term and provides for at-will employment,
terminable at any time by either party. The agreement provided for an initial
rate of annual compensation of $96,000, and annual reviews. Under the agreement,
Mr. Halstead is entitled to participate in our standard plans and policies. The
agreement also includes confidentiality and invention assignment provisions. Mr.
Halstead received a raise to $120,000, effective February 1, 2000.


STOCK OPTIONS AND OPTION PLANS

         We grant options to executive officers, employees, and consultants
under the following plans (collectively the "Plans"):

         (a)      1996 Stock Option Plan which has been terminated, but as to
                  which, there are options outstanding.

         (b)      1996 Executives' Equity Incentive Plan (the "Executives'
                  Plan") authorized the grant of options to purchase 225,000
                  stock options, which after being adjusted for stock splits
                  that occurred following the adoption of the plan resulted in
                  570,000 shares. The options granted may be either incentive
                  stock options, if they meet the requirements of Section 422 of
                  the Internal Revenue Code, or non-qualified stock options. The
                  directors approved this plan in September 1996 and the
                  shareholders in October 1996. In October 2000, our
                  shareholders approved increasing the number of stock options
                  available to 1,000,000, an increase of 430,000 stock options.
                  The directors approved this increase in August 2000.

         (c)      1996 Equity Incentive Plan (the "Employees' Plan") authorized
                  the grant of options to purchase 50,000 stock options, which
                  after being adjusted for stock splits that occurred following
                  the adoption of the plan resulted in 150,000 shares. The
                  options granted may be either incentive stock options, if they
                  meet the requirements of Section 422 of the Internal Revenue
                  Code, or non-qualified stock options. The directors approved
                  this plan in September 1996 and the shareholders in October
                  1996. In October 2000, our shareholders approved increasing
                  the number of stock options available to 500,000, an increase
                  of 350,000 stock options. The directors approved this increase
                  in August 2000.

         (d)      1998 Employee Stock Purchase Plan (the "Stock Purchase Plan")
                  authorized employee purchase of up to 200,000 shares of
                  Isonics Common Stock. The directors approved this plan in
                  August 1998,




                  and the shareholders in October 1998.


         As of January 1, 2001, options to purchase a total of 329,583 shares,
279,500 shares, and 358,769 shares respectively, were outstanding under the
Executives' Plan, Employees' Plan, and 1996 Stock Option Plan, and options to
purchase 619,417, 177,362, and 0 shares, respectively, remained available for
grant. Our shareholders were asked to approve an increase in the number of
shares of Common Stock issuable under the Employees' Plan to 500,000 and under
the Executives' Plan to 1,000,000. These increases were approved by our
shareholders at the annual meeting held October 11, 2000. The number of options
issuable under the two plans was increased by 350,000, in the Employees' Plan,
and 430,000, in the Executives' Plan.

         Except for the Director's Plan, we have not adopted any other stock
option or stock appreciation rights plan. SEE "COMPENSATION OF DIRECTORS."

                   OPTIONS/SAR GRANTS IN LAST FISCAL YEAR

         The following options were granted to executive officers named in the
compensation table during the fiscal year ended April 30, 2000. We did not grant
any stock appreciation rights to any person during fiscal year 2000, or
subsequently. There were no exercises of options or SARs by executive officers
named in the compensation table during the fiscal year ended April 30, 2000. We
have not granted any stock options to executives named in the compensation table
in fiscal 2001.




NAME AND PRINCIPAL POSITION              NUMBER OF        PERCENT OF TOTAL        EXERCISE PRICE        EXPIRATION DATE
- ---------------------------             SECURITIES           OPTIONS/ SARS                ($/SH)        ---------------
                                        UNDERLYING              GRANTED TO                ------
                                      OPTIONS/SARS            EMPLOYEES IN
                                       GRANTED (#)             FISCAL YEAR
                                       -----------             -----------
                                                                                            
James E. Alexander                               0                    0.0%                   N/A                    N/A
President & CEO
Boris Rubizhevsky                                0                    0.0%                   N/A                    N/A
Senior Vice President
Daniel J. Grady                                  0                    0.0%                   N/A                    N/A
Vice President
Stephen J. Burden                                0                    0.0%                   N/A                    N/A
Vice President (a)
Robert H. Cuttriss                               0                    0.0%                   N/A                    N/A
President of Interpro
Brantley J. Halstead                        25,000                   28.7%               $7.3125           January 2005
Vice President


- -----------

(a)      Does not include 33,333 warrants obtained in a private transaction
         completed in July 1999, and exercised in March 2000.

AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR END OPTION
VALUES

         No officer exercised employee stock options during the fiscal year
ended April 30, 2000. Mr. Halstead exercised 16,000 stock options for cash in
October 2000. These stock options were granted in April 1999, and approved by
the board of directors in October 1999.



         The following table sets forth information regarding the year-end value
of options being held by the Chief Executive Officer and the other such named
officers and persons on April 30, 2000.




NAME AND PRINCIPAL POSITION                 SHARES        VALUE            NUMBER OF SECURITIES       VALUE OF UNEXERCISED IN-THE-
- ---------------------------            ACQUIRED ON     REALIZED          UNDERLYING UNEXERCISED              MONEY OPTIONS/SARS AT
                                      EXERCISE (#)     --------                 OPTIONS/SARS AT                     APRIL 30, 2000
                                      ------------                               APRIL 30, 2000          EXERCISABLE/UNEXERCISABLE
                                                                      EXERCISABLE/UNEXERCISABLE          -------------------------
                                                                      -------------------------
                                                                                          
James E. Alexander                               0            0                        25,000/0                      $53,125.00/$0
President & CEO (a)
Boris Rubizhevsky                                0            0                        22,500/0                      $47,812.50/$0
Senior Vice President (a) (b)
Daniel J. Grady                                  0            0                       222,965/0                     $651,851.78/$0
Vice President (a)
Stephen J. Burden                                0            0                  78,599/114,288                  $166,991/$257,822
Vice President (c)
Robert H. Cuttriss                               0            0                        20,000/0                         $31,350/$0
President of Interpro
Brantley J. Halstead                             0            0                   86,000/55,000                  $321,125/$140,938
Vice President


- -----------

(a)      Does not include 45,455 shares of Common Stock awarded to Mr.
         Alexander, 36,364 shares of Common Stock awarded to Mr. Rubizhevsky,
         and 14,545 shares of Common Stock awarded to Dr. Grady in January 1999.
         These were stock grants and not grants of stock options.

(b)      Does not include 33,333 warrants obtained in a private transaction
         completed in July 1999.

(c)      Does not include 33,333 warrants obtained in a private transaction
         completed in July 1999, and exercised in March 2000.


LONG TERM INCENTIVE COMPENSATION PLANS, AND DEFINED BENEFIT AND ACTUARIAL PLANS

         Isonics has no long term incentive compensation plans, defined benefit
plans, or actuarial plans.

COMPENSATION OF DIRECTORS

         The directors of Isonics were not compensated for their services during
fiscal year 1999, or subsequently during calendar year 1999. However, each
director was reimbursed for travel and related expenses associated with Board of
Directors' meetings. In January 2000, it was agreed to compensate non-employee
directors $2,000 for attending Board of Directors' meetings in person, and $500
for attending Board of Directors' meetings telephonically beginning January 1,
2000.

         The 1998 Directors' Plan (the "Directors' Plan") authorized each person
serving as a member of the Board who is not an employee of Isonics to receive
options to purchase 20,000 shares of Isonics Common Stock when such person
accepts his position as a Director and to receive an additional option to
purchase 10,000 shares when



such person is re-elected as a Director provided such person is not an
employee of Isonics. The exercise price for the options is the Fair Market
Value (as defined in the Executives' Plan) on the date such person becomes a
director and the options are exercisable for five years from such date. The
options granted under the Directors' plan vest immediately upon the date of
the grant. In the event a Director resigns or is not re-elected to the Board,
failure to exercise the options in three months results in the options'
termination prior to the expiration of their term. Although the Directors
adopted the plan in 1998, the Board formalized the plan by resolution in
January 2000.

         Under the Directors' Plan the following individuals have been granted
options through January 1, 2001:

(a)      On May 21, 1998, Lindsay Gardner received 20,000 options exercisable at
         $2.3750 per share through May 21, 2003.

(b)      On August 1, 1998, Richard Parker received 20,000 options exercisable
         at $1.6563 per share through August 1, 2003.

(c)      On October 5, 1998, as a result of their re-election to the Board of
         Directors, Ms. Gardner and Mr. Parker each received options to acquire
         an additional 10,000 shares exercisable at $1.1875 per share through
         October 5, 2003.

(d)      On January 30, 2000, Larry J. Wells received 20,000 options exercisable
         at $7.3125 per share through January 29, 2005.

(e)      On April 26, 2000, following their re-election as directors at our
         annual meeting of shareholders, we granted options to purchase 10,000
         shares to each of Ms. Gardner and Messrs. Parker and Wells. These
         options are exercisable at $6.1250 per share through April 26, 2005.

(f)      On October 11, 2000, following their re-election as directors at our
         annual meeting of shareholders, we granted options to purchase 10,000
         shares to each of Ms. Gardner and Messrs. Parker and Wells. These
         options are exercisable at $2.1875 per share through October 10, 2005.

         As of January 1, 2001, options to purchase a total of 140,000 shares
were outstanding under the Directors Plan. We do not have any other arrangements
pursuant to which we compensate the Directors for acting in their capacities as
such.



               CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         The following sets out information regarding transactions between
officers, directors, and significant shareholders of the Company during the most
recent two fiscal years and during the subsequent fiscal year.

CORPORATE LOANS TO OFFICERS

         During the fiscal years ended April 30, 1998, 1999, and 2000, we had
loans outstanding to two officers. The funds had been advanced to the officers
to allow them to exercise options prior to our Initial Public Offering. The
options were exercised in September 1996, in part, to allow us to establish a
pool of shares available for future awards pursuant to the Plans in amounts that
comply with the guidelines established by certain state blue-sky authorities.
Interest was charged on these loans at a rate of 6.6% per annum. In minutes
effective October 31, 1999, and January 30, 2000, the Board of Directors agreed
to forgive a portion of the current interest and principal due and to accept
Isonics Common Stock, owned by the officers, in payment of the remaining balance
owed. The amount owed by Mr. Alexander, that was forgiven by the Board of
Directors, in October 1999, was $74,038.54. The amount owed by Mr. Rubizhevsky,
that was forgiven by the Board of Directors, in October 1999, was $60,534.23. In
both cases the amount forgiven was treated as bonus compensation to Mr.
Alexander and Mr. Rubizhevsky. Mr. Alexander and Mr. Rubizhevsky surrendered
30,437 shares of Isonics Common Stock each, to pay off $175,012.33 in
accumulated interest and principal ($10,012.33 in interest and $165,000.00 in
principal each). These loans were partially repaid in December 1999, and the
balances were paid in full in January 2000, and, as of April 30, 2000, and
subsequently, we had no loans receivable outstanding with our officers or
employees. Please refer to the following schedule.




                                                             JAMES E. ALEXANDER              BORIS RUBIZHEVSKY
                                                                PRESIDENT & CEO          SENIOR VICE PRESIDENT
                                                                --------------           ---------------------
                                                                                   
Balance as of May 1, 1997                                           $198,570.46                    $167,570.46
FY 1998 Borrowings (a)                                                86,662.35                      59,812.86
FY 1998 Repayments (a)                                                53,207.42                       4,040.88
                                                                      ---------                       --------
Balance as of April 30, 1998                                        $232,025.39                    $223,342.44
FY 1999 Borrowings (a)                                                 8,360.78                       3,750.51
FY 1999 Repayments (a)                                                 4,025.79                       3,767.73
                                                                       --------                       --------
Balance as of April 30, 1999                                        $236,360.38                    $223,325.22
FY 2000 Borrowings (a)                                                 7,690.49                       7,221.34
FY 2000 Repayments (a)                                               244,050.87                     230,546.56
                                                                     ----------                     ----------
Balance as of April 30, 2000                                              $0.00                          $0.00
FY 2001 Borrowings (a)                                                     0.00                           0.00
FY 2001 Repayments (a)                                                     0.00                           0.00
                                                                           ----                           ----
Balance as of December 31, 2000                                           $0.00                          $0.00


- -----------

(a)      Includes interest accrued and paid.  Amounts are aggregated.

CORPORATE LOANS FROM OFFICERS AND EMPLOYEES

         On occasion during the fiscal years ended April 30, 1998, 1999 and
2000, officers, directors, and employees of Isonics loaned Isonics funds. The
following schedule summarizes these borrowing and repayments.






NAME AND PRINCIPAL POSITION            BALANCE AS OF MAY      FY 1998 BORROWINGS      FY 1998 REPAYMENTS     BALANCE AS OF APRIL
- ---------------------------            -----------------      ------------------      ------------------     -------------------
                                                 1, 1997                     (a)                     (a)                30, 1998
                                                 -------                     ---                     ---                --------
                                                                                                 
James E. Alexander
President & CEO....................                 $0.00             $25,000.00              $25,000.00                   $0.00
Boris Rubizhevsky
Senior Vice President..............                 $0.00                  $0.00                   $0.00                   $0.00
Daniel J. Grady
Vice President.....................                 $0.00             $15,600.00              $15,600.00                   $0.00
Stephen J. Burden
Vice President (b).................                 $0.00             $86,821.92              $86,821.92                   $0.00
Lindsay Gardner
Director (c).......................                 $0.00            $122,880.28             $122,880.28                   $0.00
Jacques J. Delente (d).............           $150,000.00             $13,020.55             $163,020.55                   $0.00


- -----------

(a)      Includes interest accrued and paid through April 30, 1998.  Amounts are
         aggregated.

(b)      Dr. Burden was also granted warrants exercisable for 40,951 shares of
         Common Stock issued in connection with a private placement (the
         "Placement I") of 12% nonconvertible promissory notes and warrants to
         purchase Isonics Common Stock in September 1997.

(c)      Ms. Gardner was also granted warrants exercisable for 91,001 shares of
         Common Stock issued in connection with Placement I of 12%
         nonconvertible promissory notes and warrants to purchase Isonics Common
         Stock in September 1997.

(d)      Dr. Delente was also granted warrants exercisable for 122,853 shares of
         Common Stock issued in connection with Placement I of 12%
         nonconvertible promissory notes and warrants to purchase Isonics Common
         Stock in September 1997.





NAME AND PRINCIPAL POSITION            BALANCE AS OF MAY      FY 1999 BORROWINGS      FY 1999 REPAYMENTS     BALANCE AS OF APRIL
- ---------------------------            -----------------      ------------------      ------------------     -------------------
                                                 1, 1998                     (a)                     (a)                30, 1999
                                                 -------                     ---                     ---                --------
                                                                                                 
James E. Alexander
President & CEO....................                $0.00                   $0.00                   $0.00                    $0.00
Boris Rubizhevsky
Senior Vice President..............                $0.00              $44,290.20                   $0.00               $44,290.20
Daniel J. Grady
Vice President.....................                $0.00              $47,100.00              $47,100.00                    $0.00
Stephen J. Burden
Vice President.....................                $0.00                   $0.00                   $0.00                    $0.00
Lindsay Gardner
Director...........................                $0.00                   $0.00                   $0.00                    $0.00
Jacques J. Delente.................                $0.00              $93,000.00              $48,000.00               $45,000.00


- -----------

(a)      Includes interest accrued and paid through April 30, 1999.  Amounts are
         aggregated.






NAME AND PRINCIPAL POSITION            BALANCE AS OF MAY      FY 2000 BORROWINGS      FY 2000 REPAYMENTS     BALANCE AS OF APRIL
- ---------------------------            -----------------      ------------------      ------------------     -------------------
                                                 1, 1999                     (a)                     (a)                30, 2000
                                                 -------                     ---                     ---                --------
                                                                                                 
James E. Alexander
President & CEO....................                 $0.00                  $0.00                   $0.00                   $0.00
Boris Rubizhevsky
Senior Vice President (b)..........            $44,290.20              $8,858.04              $53,214.24                   $0.00
Daniel J. Grady
Vice President.....................                 $0.00                  $0.00                   $0.00                   $0.00
Stephen J. Burden
Vice President (c).................                 $0.00             $57,500.00              $57,500.00                   $0.00
Lindsay Gardner
Director...........................                 $0.00                  $0.00                   $0.00                   $0.00
Jacques J. Delente.................            $45,000.00             $13,500.00              $58,500.00                   $0.00


- -----------

(a)      Includes interest accrued and paid through April 30, 2000.  Amounts are
         aggregated.

(b)      Mr. Rubizhevsky's note to Isonics was converted into 66,666 shares of
         Common Stock underlying 33,333 shares of Series A Convertible Preferred
         Stock and 33,333 warrants issued in connection with a second private
         placement (the "Placement II") of Series A Convertible Preferred Stock
         and warrants to purchase Isonics Common Stock on July 30, 1999.

(c)      Dr. Burden's note to Isonics was converted into 66,666 shares of Common
         Stock underlying 33,333 shares of Series A Convertible Preferred Stock
         and 33,333 warrants issued in connection with Placement II on July 30,
         1999.

         Mr. Hegener had a loan payable to him from Isonics in the amount of
$438,314 resulting from the 1998 purchase of Chemotrade by Isonics. Isonics
issued to Mr. Hegener 35,000 warrants to purchase Common Stock at $3.00 per
share through June 30, 2004, to compensate him for a late loan payment.


                             ISONICS' CAPITAL STOCK

         Our authorized capital stock consists of 20,000,000 shares of Common
Stock and 10,000,000 shares of Preferred Stock. As of January 17, 2001, there
were outstanding 12,000,056 shares of Common Stock and 980,333 shares of Series
A Convertible Preferred Stock. As of January 17, 2001, there were also
outstanding options issued pursuant to our employee benefit plans to purchase a
total of 1,107,852 shares, and warrants to purchase a total of 4,635,023 shares
of Common Stock. The number of outstanding shares includes 3,130,435 shares
issued to Eagle-Picher pursuant to an exercise of a warrant to purchase
4,000,000. We have advised Eagle-Picher that these shares are subject to
forfeiture since Eagle-Picher failed to deliver 200 kilograms of silicon-28
meeting certain specifications to Isonics by December 31, 2000. Eagle-Picher
believes that we should issue it an additional 155,279 shares, although we
dispute this calculation and we are continuing to discuss this and other related
matters. We have invoked the dispute resolution process as defined in our
agreements with Eagle-Picher to resolve this issue and we will make a
determination regarding their Common Stock shares based on the outcome of the
dispute resolution process.

         As described above, we also have 980,333 shares of Series A Convertible
Preferred Stock outstanding,



options outstanding totaling 1,107,852, and warrants outstanding of
4,635,023. Additionally, we have reserved Common Stock shares for 1,485,000
upon the possible conversion of Class C warrants (none of which are currently
outstanding), 796,779 shares are reserved for our Employee Stock Option
Plans, and 172,063 shares of Common Stock are reserved for our Employee Stock
Purchase Plan. The total of these outstanding shares of Common Stock,
convertible and exercisable into Common Stock equity instruments, and
reserved shares of Common Stock is 21,177,106. This exceeds our authorized
capital of 20,000,000 shares, by 1,177,106 shares of Common Stock.

         Since our authorized Common Stock is only 20,000,000 shares, we will
not be able to issue any shares in excess of 20,000,000, and we may become
liable for our inability to issue shares as we have committed to do. We intend
to propose an amendment to our Articles of Incorporation to increase our
authorized capital as a special meeting of shareholders, which we expect to hold
in March or April 2001. However, there can be no assurance that we will be able
to obtain approval of an increase in our authorized capitalization from our
shareholders at the meeting when held. Until then, and thereafter, if the
shareholders do not approve the increase we are potentially liable for our
inability to issue all shares as committed.

COMMON STOCK

         Subject to preferences that may be applicable to any Preferred Stock
outstanding at the time, the holders of outstanding shares of Common Stock are
entitled to receive dividends out of assets legally available therefor at such
times and in such amounts as the Board of Directors may from time to time
determine.

         Each shareholder is entitled to one vote for each share of Common Stock
held on all matters submitted to a vote of shareholders.

         Cumulative voting for the election of directors is specifically
authorized by the Bylaws. Under cumulative voting for the election of directors,
upon a proper and timely request by a shareholder, each shareholder is entitled
to cast a number of votes equal to the number of shares held multiplied by the
number of directors to be elected. The votes may be cast for one or more
candidates. Thus, under cumulative voting, a majority of the outstanding shares
will not necessarily be able to elect all of the directors, and minority
shareholders may be entitled to greater voting power with respect to election of
directors than if cumulative voting did not apply.

         The Bylaws provide that so long as we are a "listed company" as defined
by applicable California law, there will not be cumulative voting in connection
with the election of directors. At the present time, we are not a "listed
company" as defined in California law, and therefore cumulative voting will
continue to apply in connection with the election of directors.

         The Common Stock is not entitled to preemptive rights and is not
subject to conversion or redemption. Upon liquidation, dissolution or winding up
of Isonics, the remaining assets legally available for distribution to
shareholders, after payment of claims or creditors and payment of liquidation
preferences, if any, on outstanding Preferred Stock, are distributable ratably
among the holders of the Common Stock and any participating Preferred Stock
outstanding at that time. Each outstanding share of Common Stock is fully paid
and nonassessable.

PREFERRED STOCK

         The Board of Directors is authorized, subject to any limitations
prescribed by California law, to provide for the issuance of shares of Preferred
Stock in one or more series, to establish from time to time the number of shares
to be included in each such series, to fix the rights, preferences and
privileges of the shares of each unissued series and any qualifications,
limitations or restrictions thereon, and to increase or decrease the number of
shares of any such series (but not below the number of shares of such series
then outstanding), without any further vote or action by the shareholders. The
Board of Directors may authorize the issuance of Preferred Stock with voting or



conversion rights that could adversely affect the voting power or other rights
of the holders of Common Stock. Thus, the issuance of Preferred Stock may have
the effect of delaying, deferring, or preventing a change in control of Isonics.

         We have issued 1,830,000 shares of our Series A Preferred Stock. This
Preferred Stock may be converted to common shares of Isonics stock at a fixed
conversion price of $1.50 per share, which would result in the exchange of one
share of Common Stock for each share of Series A Convertible Preferred Stock.
This conversion ratio is subject to dilution adjustments. The Series A
Convertible Preferred Stock is entitled to receive dividends on a
share-for-share basis with the shares of Common Stock except in the case of a
"Silicon Isotope Transaction" as defined in the Certificate of Determination
that was filed with the California Secretary of State to create the Series A
Convertible Preferred Stock. The Series A Convertible Preferred Stock is
entitled to a liquidation preference of $1.50 per share.

CLASS A REDEEMABLE WARRANTS

         Class A Redeemable Warrants, ("Class A Warrants,") to purchase Common
Stock were issued in September 1997, and are registered pursuant to Section
12(g) of the Securities Exchange Act of 1934, as amended. The following is a
brief summary of certain provisions of the Warrants.

         We issued Class A Warrants to purchase an aggregate of 810,000 shares
of Common Stock. We have also reserved 810,000 shares for issuance upon exercise
of the Class A Warrants. Each Class A Warrant entitles the registered holder
thereof to purchase one share of Common Stock at a price of $5.80, subject to
adjustment, through September 21, 2001. After expiration, the Class A Warrants
will be void and of no value.

         We may redeem the Class A Warrants at a price of $0.10 per Warrant on
not less than 30 days' prior written notice if the average of the last reported
bid and asked prices of the Common Stock (if the Common Stock is then traded in
the over-the-counter market) or the last reported sale price of the Common Stock
(if the Common Stock is then traded on a national securities exchange or the
Nasdaq National Market or SmallCap Market) has been at least $14.50 per share
(subject to adjustment) for at least 20 consecutive trading days ending within
three days prior to the date on which notice of redemption is given.

         The Warrants contain provisions that protect the holders thereof
against dilution by adjustment of the exercise price and number of shares
issuable upon exercise, on the occurrence of certain events, such as stock
dividends, stock splits and recapitalizations. We are not required to issue
fractional shares. In lieu of the issuance of such fractional shares, we will
pay cash to such holders of the Warrants. In computing the cash payable to such
holders, a share of Common Stock will be valued at its price immediately prior
to the close of business on the expiration date. The holder of a Warrant will
not possess any rights as a shareholder of Isonics unless such shareholder
exercises such Warrant.

CLASS B REDEEMABLE WARRANTS AND CLASS C REDEEMABLE WARRANTS

         On December 13, 2000, we issued 675,000 restricted Class B Warrants. As
of the date of this prospectus, January 17, 2001, no Class B Redeemable
Warrants, ("Class B Warrants,") have yet been issued as a result of the exchange
offer. However, up to 810,000 additional Class B Warrants will be issued to
holders of our Class A Warrants who accept the exchange offer.

         No Class C Redeemable Warrants, ("Class C Warrants,") have yet been
issued, but they will be issued to persons who exercise their Class A Warrants
prior to the expiration of the exchange offer, or who exercise their Class B
Warrants prior to their expiration. The Class B Warrants (810,000 only that
would be issued as a result of Class A Warrants being exchanged) and the Class C
Warrants (810,000 only that would be issued upon the exercise of either Class A
Warrants or upon the exercise of Class B Warrants received upon the exchange of
Class



A Warrants) have been registered pursuant to Section 12(g) of the Securities
Exchange Act of 1934, as amended. The additional 675,000 restricted Class B
Warrants, and Class C Warrants that would be issued upon the exercise of
these restricted Class B Warrants, will be registered in the near future.

         The Class B Warrants and the Class C Warrants contain provisions that
protect the holders thereof against dilution by adjustment of the exercise price
and number of shares issuable upon exercise, on the occurrence of certain
events, such as stock dividends, stock splits, and recapitalizations. We are not
required to issue fractional shares. In lieu of the issuance of such fractional
shares, we will pay cash to such holders of the Warrants. In computing the cash
payable to such holders, a share of Common Stock will be valued at its price
immediately prior to the close of business on the expiration date. The holder of
a Warrant will not possess any rights as a shareholder of Isonics unless such
shareholder exercises such Warrant.

         The material terms and conditions of the Class B Warrants and the Class
C Warrants are summarized above. SEE "THE EXCHANGE OFFER."

UNDERWRITERS' WARRANTS

         Upon the completion of our initial public offering in September 1997,
we issued warrants to purchase 80,000 units to our underwriter. The
Underwriters' Warrants are exercisable at $9.57 per Unit and expire on September
1, 2002. If any of the Underwriters' Warrants are exercised, the holder will
receive one share of our Common Stock and one Class A Warrant for each
Underwriters' Warrant properly exercised. If issued upon exercise of the
Underwriters' Warrant, the Class A Warrant will be subject to the Exchange Offer
(which expires on April 30, 2001) and to the other terms of the Class A Warrant
agreement. This prospectus assumes that no Underwriters' Warrants will be
exercised.


            MARKET FOR COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

         On September 22, 1997, our Units (consisting one share of Common Stock
and one Class A Warrant) started trading on the Over The Counter (OTC) Bulletin
Board under the symbol ISONU. In October 1997, we unbundled the Units and the
Common Stock and Class A Warrants commenced trading on the OTC Bulletin Board
under the symbols ISON and ISONW, respectively. Although the Class B Warrants
(symbol "ISONX") and the Class C Warrants ("ISONY") are also eligible for
trading, no Class C Warrants have been issued and only 675,000 restricted Class
B Warrants have been issued which are not eligible for trading; consequently, no
market has developed for either the Class B Warrant or the Class C Warrant.

         The following table sets forth the high and low bid prices for the
Common Stock (quotations reflect inter-dealer prices, without retail mark-up,
mark-down or commission and may not represent actual transactions) from May 1,
1998 through July 12, 2000 as reported by OTC Bulletin Board, and beginning July
13, 2000, by the Nasdaq SmallCap Market.




                                                                 QUARTER ENDED
                                                                 -------------
                                  JULY 31, 2000       OCT. 31, 2000         JAN. 31, 2001*
                                  -------------       -------------         --------------
                                                                   
Common Stock (ISON)
   High                           7.0625              4.0000                2.6265
   Low                            3.3750              1.4375                1.0625


- -----------

*        through January 1, 2001






                                                                 QUARTER ENDED
                                                                 -------------
                                   JULY 31, 1999       OCT. 31, 1999        JAN. 31, 2000       APR. 30,
                                   -------------       -------------        -------------       2000
                                                                                                ----
                                                                                    
Common Stock (ISON)
   High                            3.6250              2.1250               10.5000             17.9375
   Low                             1.8750              0.8750               1.2500              5.5625





                                                                 QUARTER ENDED
                                                                 -------------
                                   JULY 31, 1998       OCT. 31, 1998        JAN. 31, 1999       APR. 30,
                                   -------------       -------------        -------------       1999
                                                                                                ----
                                                                                    
Common Stock (ISON)
   High                            2.7188              1.9063               2.0000              3.5625
   Low                             1.6563              1.0313               0.7813              1.4375



         As of December 31, 2000, there were approximately 250 holders of record
of our Common Stock. This does not include an indeterminate number of persons
who hold our Common Stock in brokerage accounts and otherwise in "street name."

         We have never declared or paid a cash dividend on our Common Stock. We
presently intend to retain our earnings to fund development and growth of our
business and, therefore, do not anticipate paying any cash dividends in the
foreseeable future. Additionally, the certificate of designation for the Series
A Convertible Preferred Stock contains restrictions on our ability to pay
dividends to holders of our Common Stock.


                        SHARES AVAILABLE FOR FUTURE SALE

         The market price of our Common Stock could drop if substantial amounts
of shares are sold in the public market or if the market perceives that such
sales could occur. A drop in the market price could adversely affect holders of
the stock and could also harm our ability to raise additional capital by selling
equity securities. The securities that may be sold from time to time under this
prospectus represent a market overhang.

         As of January 17, 2001, we had outstanding options and warrants for the
purchase of up to approximately 5,742,875 shares of Common Stock at an average
price of $3.25 per share, representing approximately 30.1% of our outstanding
shares of Common Stock on a fully-diluted basis. Additionally, we have 1,180,333
shares of Series A Convertible Preferred Stock outstanding convertible to
1,180,333 shares of our Common Stock. The sum of these convertible securities,
6,776,979 represent 36.5% of our outstanding shares of Common Stock on a
fully-diluted basis.

         The perception that these instruments may be exercised for, or
converted into, Common Stock that then could be sold into the public market
could adversely affect the market price of our Common Stock. In addition, we
have entered into registration rights agreements with certain of our
stockholders entitling them to include their shares of Common Stock in
registration statements for securities filed by Isonics under the Securities Act
of 1933, as amended. Effective October 10, 2000, virtually all of the Common
Stock shares underlying these convertible securities were registered. Awareness
of the existence of these registration rights could lead to a perception that
sales of the shares subject to the registration rights could occur, which could
materially and adversely affect our stock price or could impair our ability to
obtain capital through sales of equity securities. In addition, shares we have
issued in private transactions over the past two years will become eligible for
sale in the public market under



SEC Rule 144.

         These shares are restricted securities as defined in Rule 144. Under
that rule, a stockholder who owns restricted shares that have been
outstanding for at least one year is entitled to sell, within any three-month
period, a number of restricted shares that does not exceed the greater of:
(i) 1% of the then outstanding shares of Common Stock, or approximately
120,000 shares as of December 31, 2000; and (ii) an amount equal to the
average weekly trading volume in the Common Stock during the four calendar
weeks preceding the sale. The average weekly trading volume in December 2000,
adjusted for days the markets were closed because of holidays was
approximately 1,017,000.

              SECURITIES AND EXCHANGE POSITION ON INDEMNIFICATION FOR
                              SECURITIES ACT LIABILITIES

         The Articles of Incorporation of Isonics require it to indemnify its
officers, directors, employees and agents against certain liabilities
incurred by them in those capacities if they acted in good faith and
reasonably believed their conduct was in the best interests of Isonics or not
opposed to it. Isonics is also required to indemnify a person who is or was a
director, officer, employee or agent of Isonics and who was successful, on
the merits or otherwise, in defense of any proceeding to which he was a
party, against reasonable expenses, which include attorneys' fees, incurred
by him or her in connection with the proceeding.

         Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and
controlling persons of Isonics under the provisions discussed in the previous
paragraph, or otherwise, Isonics has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public
policy as expressed in that Act and is, therefore, unenforceable.

                                     EXPERTS

         The consolidated balance sheets as of April 30, 1999 and 2000, and
the consolidated statements of operations, stockholders' equity, and cash
flows for the years then ended have been audited by Grant Thornton LLP,
independent certified public accountants, as set forth in their report
thereon appearing elsewhere herein and in the Registration Statement, and are
included in reliance upon such report given upon the authority of such firm
as experts in accounting and auditing.

                                  LEGAL MATTERS

         Certain legal matters, have been passed upon for Isonics by
Norton-Lidstone, P.C., Englewood, Colorado. Arter & Hadden, LLP, Los Angeles,
California, has passed on the validity of the shares of Common Stock offered
hereby under California law.

                      HOW TO OBTAIN ADDITIONAL INFORMATION

         We file annual and quarterly reports, proxy statements, and other
information with the Securities and Exchange Commission (the "SEC"). You may
read and copy any document we have filed with the SEC in its public reference
room at 450 Fifth Street N.W. Washington, D.C. 20549. You may obtain
information on the operation of the public reference room by calling the SEC
at 1-800-432-0330. The SEC maintains a World Wide Web site on the Internet at
http://www.sec.gov that contains reports, proxy and information statements,
and other information regarding companies, including those that Isonics files
electronically with the SEC.




         We also furnish Annual Reports to our shareholders that contain
audited financial information.

         This prospectus is part of a registration statement we have filed
with the SEC relating to this exchange offer and our Common Stock described
in this prospectus. As permitted by the SEC rules, this prospectus does not
contain all of the information contained in the registration, accompanying
exhibits and schedules we file with the SEC. You may refer to the
registration, the exhibits and schedules for more information about our
Company and our Common Stock. The registration statement, exhibits, and
schedules are also available at the SEC's public reference rooms or through
its EDGAR database on the Internet.

         You should rely only on the information contained or incorporated by
reference in this prospectus. Isonics has not authorized anyone to provide
you with information that is different from what is contained in this
prospectus. You should not assume that the information contained in this
prospectus is accurate as of any date other than the date set forth on the
front cover of this prospectus.








                      ISONICS CORPORATION AND SUBSIDIARIES

                   Index to Consolidated Financial Statements


                                                                                                                              PAGE
                                                                                                                              ----
                                                                                                                           
Report of Independent Certified Public Accountants                                                                             F-2
Consolidated Financial Statements for the Years Ended April 30, 1999 and 2000
   Consolidated Balance Sheets                                                                                                 F-3
   Consolidated Statements of Operations                                                                                       F-4
   Consolidated Statement of Stockholders' Equity                                                                              F-5
   Consolidated Statements of Cash Flows                                                                                       F-6
   Notes to Consolidated Financial Statements                                                                                  F-7
Condensed Consolidated Financial Statements for the Three and Six Months Ended October 31, 1999 and 2000
   Condensed Consolidated Balance Sheets                                                                                      F-21
   Condensed Consolidated Statements of Operations                                                                            F-22
   Condensed Consolidated Statements of Cash Flows                                                                            F-23
   Notes to Condensed Consolidated Financial Statements                                                                       F-24








                     REPORT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

Board of Directors

Isonics Corporation and Subsidiaries

We have audited the accompanying consolidated balance sheets of Isonics
Corporation and Subsidiaries as of April 30, 2000 and 1999, and the related
consolidated statements of operations, stockholders' equity, and cash flows
for the years then ended. These financial statements are the responsibility
of the Company's management. Our responsibility is to express an opinion on
these financial statements based on our audits.

We conducted our audits in accordance with auditing standards generally
accepted in the United States of America. Those standards require that we
plan and perform the audit to obtain reasonable assurance about whether the
financial statements are free of material misstatement. An audit includes
examining, on a test basis, evidence supporting the amounts and disclosures
in the financial statements. An audit also includes assessing the accounting
principles used and significant estimates made by management, as well as
evaluating the overall financial statement presentation. We believe that our
audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in
all material respects, the consolidated financial position of Isonics
Corporation and Subsidiaries as of April 30, 2000 and 1999, and the
consolidated results of their operations and their consolidated cash flows
for the years then ended, in conformity with accounting principles generally
accepted in the United States of America.

GRANT THORNTON LLP

San Jose, California
June 26, 2000







                            ISONICS CORPORATION AND SUBSIDIARIES
                                 CONSOLIDATED BALANCE SHEETS
                            (IN THOUSANDS, EXCEPT SHARE AMOUNTS)




                                                                                                                       APRIL 30,
                                                                                                                      --------
                                                                                                                 2000         1999
                                                                                                                 ----         ----
                                                                                                                        
                                                 ASSETS
CURRENT ASSETS:
   Cash and cash equivalents...........................................................................          $3,385        $452
   Accounts receivable (net of allowances of $119 and $82, respectively)...............................           1,055         932
   Note receivable.....................................................................................             208          --
   Inventories.........................................................................................             266         651
   Prepaid expenses....................................................................................             209         160
   Deferred income taxes, current......................................................................             148          --

      Total current assets.............................................................................           5,271       2,195
PROPERTY AND EQUIPMENT, net............................................................................             660       1,018
GOODWILL, net..........................................................................................           3,062       3,388
NOTES RECEIVABLE FROM SHAREHOLDERS.....................................................................              17         130
DEFERRED INCOME TAXES..................................................................................             492          --
OTHER ASSETS...........................................................................................              31          75

                                                                                                                 $9,533      $6,806
                                                                                                                 ------      ------


                                  LIABILITIES AND STOCKHOLDERS' EQUITY
CURRENT LIABILITIES:
   Current portion of long-term debt and line of credit................................................             $20      $1,136
   Notes payable to related parties....................................................................              --         922
   Accounts payable....................................................................................             533       1,368
   Accrued liabilities.................................................................................             591       1,036
   Income taxes payable................................................................................             373          50

      Total current liabilities........................................................................           1,517       4,512
STOCKHOLDERS' EQUITY
   Class A Preferred Stock--no par value; 10,000,000 shares authorized; shares issued and outstanding:
      2000--1,830,000..................................................................................           2,745          --
   Common stock--no par value; 20,000,000 shares authorized; shares issued and outstanding:
      2000--10,492,931; 1999--6,607,760................................................................           6,764       6,795
   Notes receivable from shareholders..................................................................              --        (469)
   Deferred compensation...............................................................................            (150)         --
   Accumulated deficit.................................................................................          (1,343)     (4,032)

      Total stockholders' equity.......................................................................           8,016       2,294

                                                                                                                 $9,533      $6,806
                                                                                                                 ------      ------



                          See Notes to Consolidated Financial Statements.







                                 ISONICS CORPORATION AND SUBSIDIARIES
                                 CONSOLIDATED STATEMENTS OF OPERATIONS
                                (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)




                                                                                                                     YEAR ENDED
                                                                                                                      APRIL 30,
                                                                                                                   ----------------
                                                                                                                    2000      1999
                                                                                                                    ----      ----
                                                                                                                     
Net revenues..............................................................................................       $12,733   $16,998
Cost of revenues..........................................................................................        10,156    13,375

   Gross margin...........................................................................................         2,577     3,623
Operating expenses:
   Selling, general and administrative....................................................................         3,698     3,643
   Research and development...............................................................................         1,224     1,155
   Restructuring and office closure.......................................................................            56       691

      Total operating expenses............................................................................         4,978     5,489

Operating loss............................................................................................       (2,401)    (1,866)
Other income (expense)
   Interest income........................................................................................           105        36
   Interest expense.......................................................................................         (321)      (575)
   Gain on sale of product line...........................................................................         5,296        --
   Foreign currency gain..................................................................................            29        55
   Other..................................................................................................           110        --

      Total other income (expense), net...................................................................         5,219      (484)

Income (loss) before taxes................................................................................         2,818    (2,350)
Income tax expense........................................................................................           129       171

NET INCOME (LOSS).........................................................................................        $2,689   $(2,521)
                                                                                                                  ------   -------


NET INCOME (LOSS) PER SHARE--BASIC
   Net income (loss) per share............................................................................         $0.40   $ (0.41)
   Shares used in computing per share information.........................................................         6,781     6,210
NET INCOME (LOSS) PER SHARE--DILUTED
   Net income (loss) per share............................................................................         $0.26   $ (0.41)
   Shares used in computing per share information.........................................................        10,409     6,210
                                                                                                                  ------   -------

                          See Notes to Consolidated Financial Statements.







Isonics Corporation and Subsidiaries CONSOLIDATED STATEMENT OF STOCKHOLDERS'
EQUITY (In thousands, except share amounts)


                                PREFERRED STOCK           COMMON STOCK      SHAREHOLDER
                               -------------------    ------------------        NOTES          DEFERRED    (ACCUMULATED)
                               SHARES     AMOUNT       SHARES     AMOUNT     RECEIVABLE      COMPENSATION     DEFICIT)     TOTAL
                                 ------     ------      ------     ------     ----------      ------------   ------------  -------
                                                                                                   
BALANCES, May 1, 1998.......         --     $  --     5,714,250     $5,289         $(337)            $--        $(1,511)   $3,441
   Issuance of common stock
      for Chemotrade
      acquisition...........         --        --       357,730        894            --              --             --       894
   Issuance of common stock
      in lieu of salaries...         --        --       118,182        130            --              --             --       130
   Conversion of debt into
      common stock..........         --        --       127,209        191            --              --             --       191
   Exercise of stock options
      and warrants..........         --        --       290,389        147          (130)             --             --        17
   Fair value of warrants
      issued with debt......         --        --            --        144            --              --             --       144
   Interest on notes
      receivable from
      stockholders, net of
      repayments............         --        --            --         --            (2)             --             --        (2)
   Net loss.................         --        --     6,607,760      6,795          (469)             --         (4,032)    2,294
BALANCES, April 30, 1999....         --        --            --         --            --              --         (2,521)   (2,521)
   Issuance of preferred stock
   Exercise of stock options..1,830,000     2,745            --         --            --              --             --     2,745
      and warrants..........         --        --     3,918,986         81            --              --             --        81
   Fair value of warrants
      issued for debt
      restructuring.........         --        --            --        157            --              --             --       157
   Fair value of stock issued
      for services as
      deferred compensation..        --        --        25,000        153            --            (153)            --        --
   Amortization of deferred
      compensation..........         --        --            --         --            --               3             --         3
   Shares issued under
      Employee Stock Purchase
      Program...............         --        --        13,723         13            --              --             --        13
   Repayment of notes
      receivable from
      stockholders, net of
      interest..............         --        --            --         --            34              --             --        34
   Repayment of notes
      receivable and accrued
      interest with common
      stock.................         --        --       (72,538)      (435)          435              --             --        --
   Net income...............         --        --            --         --            --              --          2,689     2,689
BALANCES, April 30, 2000....  1,830,000    $2,745    10,492,931     $6,764           $--           $(150)       $(1,343)   $8,016
                              ---------    ------    ----------     ------         ------         ------        --------   ------




                           See Notes to Consolidated Financial Statements.







Isonics Corporation and Subsidiaries CONSOLIDATED STATEMENTS OF CASH FLOWS
(In thousands)


                                                                                                                    YEAR ENDED
                                                                                                                     APRIL 30,
                                                                                                                    -----------
                                                                                                                   2000     1999
                                                                                                                   ----     ----
                                                                                                                      
CASH FLOWS FROM OPERATING ACTIVITIES:
   Net income (loss)...................................................................................         $2,689     $(2,521)
   Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
      Gain on sale of depleted zinc business...........................................................         (5,296)         --
      Depreciation and amortization....................................................................            567         520
      Interest on notes receivable from shareholders...................................................            (23)        (24)
      Fair value of warrants and stock issued and amortization of deferred compensation................            160         274
      Interest recognized upon conversion of debt to equity............................................             --          64
      Deferred income taxes............................................................................           (640)         --
      Loss on disposal of property and equipment.......................................................             75         504
      Forgiveness of notes receivable due from stockholders............................................             27          --
      Changes in operating assets and liabilities:
        Accounts and notes receivable..................................................................           (146)      1,748
        Inventories....................................................................................         (1,066)        (89)
        Prepaid expenses and other assets..............................................................           (139)         68
        Accounts payable...............................................................................           (522)       (112)
        Accrued liabilities and other..................................................................           (336)        (30)
        Income taxes payable...........................................................................            323         (45)

              Net cash provided by (used in) operating activities......................................         (4,327)        357
CASH FLOWS FROM INVESTING ACTIVITIES:
   Purchases of property and equipment.................................................................            (15)       (159)
   Proceeds from sale of depleted zinc business........................................................          6,730         --
   Purchase of Chemotrade, net of cash acquired........................................................             --        (546)

              Net cash provided by (used in) investing activities......................................          6,715        (705)
CASH FLOWS FROM FINANCING ACTIVITIES:
   Payments on line of credit and other borrowings.....................................................         (1,931)     (1,000)
   Proceeds from borrowings............................................................................             75         717
   Repayment of notes receivable from shareholders.....................................................             57          22
   Proceeds from issuance of preferred stock...........................................................          2,250          --
   Proceeds from issuance of common stock..............................................................             94          17

              Net cash provided by (used in) financing activities......................................            545        (244)

              NET INCREASE (DECREASE) IN CASH AND EQUIVALENTS..........................................          2,933        (592)
Cash and cash equivalents at beginning of period.......................................................            452       1,044

Cash and cash equivalents at end of period.............................................................         $3,385       $ 452
                                                                                                                ------       -----





                       See Notes to Consolidated Financial Statements.







Isonics Corporation and Subsidiaries NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

NOTE 1--ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES


ORGANIZATION

         Isonics Corporation ("We" or the "Company") develop and market
products worldwide based on isotopes for applications in the energy, medical
research, diagnostic, pharmaceutical and semiconductor industries. Through
one of our subsidiaries, we also provide contract research and development
services.

PRINCIPALS OF CONSOLIDATION

         The consolidated financial statements include our accounts and those
of our wholly-owned subsidiaries, International Process Research Corporation
("Interpro") and Chemotrade GmbH ("Chemotrade"). All significant intercompany
accounts have been eliminated in consolidation.

CASH EQUIVALENTS

         Cash equivalents include investments purchased with a maturity of
less than ninety days. Cash balances held in foreign bank accounts were
$151,000 at April 30, 2000.

CONCENTRATION OF CREDIT RISK

         Financial instruments that potentially subject us to concentrations
of credit risk consist primarily of cash equivalents and trade accounts
receivable. Cash equivalents are maintained with high quality institutions
and are regularly monitored by management. We extend credit to our customers,
most of whom are large, established companies. Credit risk is mitigated by
performing ongoing credit evaluations of our customers' financial condition
and we generally do not require collateral.

INVENTORIES

         Inventories are stated at the lower of cost (first-in, first-out) or
market. We perform periodic assessments to determine the existence of
obsolete, slow moving and non-salable inventories, and record provisions to
reduce such inventories to net realizable value when necessary.

PROPERTY AND EQUIPMENT

         Property and equipment are stated at cost. Depreciation is computed
using the straight-line method over three-to-seven years. Leasehold
improvements are amortized over the shorter of their estimated useful lives
or the lease term.

GOODWILL

         Goodwill resulted from the acquisitions of Isoserve, Inc. and
Chemotrade. We evaluate goodwill for impairment by comparing the unamortized
balance of goodwill to the undiscounted future cash flows of the related
assets. We modify or adjust goodwill if impairment is indicated. Based upon
our most recent evaluation, we believe that no impairment of goodwill exists
as of April 30, 2000; however, with the sale of the depleted zinc business to
Eagle-Picher on December 1, 1999, unamortized goodwill of $112,000 related to
the Isoserve, Inc. acquisition was charged against the gain on the sale of
the product line. The goodwill resulting from the Chemotrade acquisition is
being amortized on a straight-line basis over twenty years.



INCOME TAXES

         We account for income taxes using an asset and liability approach
for financial accounting and reporting purposes. A valuation allowance is
provided when deferred tax assets are not expected to be realized.

REVENUE RECOGNITION

         Revenue from product sales is recognized upon shipment. Product
returns and warranty costs have not been material in any period. Revenue from
contract research and development services is recognized ratably as services
are performed and costs are incurred.

USE OF ESTIMATES IN THE FINANCIAL STATEMENTS

         In preparing financial statements in conformity with accounting
principles generally accepted in the United States of America, we are
required to make estimates and assumptions that affect the reported amounts
of assets and liabilities and the disclosure of contingent assets and
liabilities at the date of the financial statements, as well as revenues and
expenses during the reporting period. Actual results could differ from those
estimates.

FAIR VALUES OF FINANCIAL INSTRUMENTS

         The fair value of cash and equivalents, trade receivables, trade
payables, and debt approximates carrying value due to the short maturity of
such instruments.

TRANSLATION OF FOREIGN CURRENCIES

         We conduct substantially all of our transactions in U.S. dollars,
except for certain transactions of Chemotrade that are conducted in Duetsche
Marks. The financial statements of Chemotrade are prepared in Duetsche Marks
and remeasured into U.S. dollars for purposes of consolidation, with the U.S.
dollar as the functional currency. Gains and losses from remeasurement and
transaction gains and losses are included in the statement of operations.

ACCOUNTING FOR STOCK-BASED COMPENSATION

         We account for stock-based awards to employees and directors using
the intrinsic value method in accordance with Accounting Principles Board
Opinion No. 25, Accounting for Stock Issued to Employees and related
interpretations. We provide additional pro forma disclosures as required
under Statement of Financial Accounting Standards ("SFAS") No. 123,
Accounting for Stock-Based Compensation.

NET INCOME (LOSS) PER SHARE

         Basic earnings per share is computed using the weighted average
number of common shares outstanding during the period. Diluted earnings per
share is computed using the weighted average number of common shares and
potentially dilutive securities outstanding during the period. Potentially
dilutive securities consist of the incremental common shares issuable upon
conversion of preferred stock (using the "if converted" method) and shares
issuable upon the exercise of stock options and warrants (using the "treasury
stock" method). Potentially dilutive securities are excluded from the
computation if their effect is anti-dilutive. Contingently issued shares are
included in earnings per share when the related conditions are satisfied.

         The following table reconciles the denominator used in the per share
computation (in thousands):





                                                                                                         YEAR ENDED
                                                                                                          APRIL 30,
                                                                                                        -------------
                                                                                                        2000     1999
                                                                                                        ----     ----
                                                                                                           
Weighted average shares of common stock outstanding...............................................      7,174    6,210
Less: weighted average shares contingently issued.................................................       (393)     --
   Shares used for net income (loss) per share - basic............................................      6,781    6,210
Dilutive effect of stock options and warrants.....................................................      1,850       --
Dilutive effect of convertible preferred stock....................................................      1,385       --
Add back: weighted average shares contingently issued.............................................        393       --

   Shares used for net income (loss) per share - diluted..........................................     10,409    6,210
                                                                                                       ------    -----



         A total of 3,464,047 shares issuable from the exercise of
outstanding options and warrants were excluded from the calculation of loss
per share in 1999, as their inclusion would have been anti-dilutive.

RECLASSIFICATIONS

         Certain reclassifications have been made to the 1999 financial
statements in order to conform to the 2000 presentation.

NOTE 2--FINANCIAL STATEMENT COMPONENTS

         Inventories consist of the following (in thousands):



                                                                                                              APRIL 30,
                                                                                                            ------------
                                                                                                            2000    1999
                                                                                                            ----    ----
                                                                                                              
Finished goods                                                                                              $139    $420
Work in process                                                                                              127      --
Raw materials                                                                                                 --     231

                                                                                                            $266    $651
                                                                                                            ----    ----



         Property and equipment consists of the following (in thousands):



                                                                                                              APRIL 30,
                                                                                                            ------------
                                                                                                            2000    1999
                                                                                                            ----    ----
                                                                                                              
Office furniture and equipment                                                                             $174      $159
Production equipment                                                                                        898     1,094
Leasehold improvements                                                                                       19        19
                                                                                                          1,091     1,272
Accumulated depreciation and amortization                                                                  (431)     (254)
                                                                                                           $660    $1,018
                                                                                                           ----    ------




         Goodwill related to acquisitions consists of the following (in
thousands):



                                                                                                              APRIL 30,
                                                                                                            ------------
                                                                                                            2000    1999
                                                                                                            ----    ----
                                                                                                           
Isoserve, net of accumulated amortization of $472 and $315                                                  $--     $157
Chemotrade, net of accumulated amortization of $323 and $154                                              3,062    3,231
                                                                                                         $3,062   $3,388
                                                                                                         ------   ------




         Accrued liabilities consist of the following (in thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Compensation                                                                                               $68      $391
Interest                                                                                                    --        68
Customer advances and deposits                                                                             194        97
Restructuring costs                                                                                         47        61
Other                                                                                                      282       419
                                                                                                          $591    $1,036
                                                                                                          ----    ------



         Supplemental disclosure of non-cash investing and financing activities
(in thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Stock issued for note receivable.................................................................        $--        $130
                                                                                                         ----       ----
Conversion of trade payables into debt...........................................................        $243        $95
                                                                                                         ----       ----
Conversion of liabilities and debt into preferred stock..........................................        $495        $--
                                                                                                         ----       ----
Retirement of common stock to pay shareholder notes receivable...................................        $435        $--

Purchase of Chemotrade
   Cash paid.....................................................................................        $--        $546
   Cash acquired.................................................................................         --         309
   Stock issued to seller........................................................................         --         894
   Debt issued to seller.........................................................................         --       1,750
   Liabilities assumed...........................................................................         --       1,598
   Goodwill......................................................................................         --      (3,385)
   Assets acquired...............................................................................        $--      $1,712
                                                                                                         ----       ----


         Supplemental disclosures of cash flow information (in thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Cash paid during the period for:
   Interest                                                                                               $388    $475
   Income taxes                                                                                            433     227


NOTE 3--ACQUISITIONS

         On July 21, 1998, we acquired all of the outstanding shares of
Chemotrade and a subsidiary, which was owned by two shareholders. Chemotrade
is engaged in the distribution, development, and manufacturing of stable and
radioisotopes. The purchase was effective June 1, 1998, the date control was
transferred, and our financial



statements include the results of Chemotrade's operations from June 1, 1998.
Pro forma results of operations for 1999 have not been presented as the pro
forma amounts would not have been materially different than those reported.

         The consideration paid upon closing consisted of $546,000 cash,
357,730 restricted shares of common stock with a fair market value of
$894,000, and two notes. The first note of $924,000 (DM 1,663,000) bore
interest at 2% per month and was paid in August 1998, and the second note of
$812,000 (DM 1,500,000) bore interest at 10% per year and was paid by
December 1999. Transaction costs were $125,000. Imputed interest from the
effective date of the acquisition totaled $28,000.

         The purchase agreement provides for the selling shareholders to
receive additional consideration in the event pretax earnings of $467,000 (DM
1,000,000) are achieved for the year ending April 30, 2001. The maximum
additional consideration that can be earned is $234,000 (DM 500,000). Any
additional consideration will be recorded as additional goodwill.

NOTE 4--SALE OF DEPLETED ZINC BUSINESS

         On December 1, 1999, we sold our depleted zinc business to
Eagle-Picher Technologies, LLC ("Eagle-Picher") for $8,230,000, including
$1,500,000 to be paid over a period of three years. We received cash of
approximately $6,730,000 from Eagle-Picher at the closing, of which
approximately $1,150,000 was used to pay certain accrued liabilities and
debt. Upon completion of the sale, we recognized a net gain on the sale
amounting to $5,088,000. Eagle-Picher's obligation to pay the final
$1,500,000 is subject to the performance of our former depleted zinc supplier
under the terms of a supply agreement that was transferred to Eagle-Picher in
the sale. We are recognizing the $1,500,000 on a straight-line basis as our
former supplier performs. As a result, we have recognized additional gain of
$208,000 through April 30, 2000, which is reported as a note receivable at
April 30, 2000.



Isonics Corporation and Subsidiaries NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

NOTE 5--INCOME TAXES

         Deferred tax assets (liabilities) are comprised of the following (in
thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Deferred tax assets
   Accruals and expenses deductible in future periods                                                   $1,609   $1,269
   Net operating loss carryforwards                                                                         --      435
      Total deferred tax assets                                                                          1,609    1,704
   Valuation allowance                                                                                    (376)  (1,178)
                                                                                                         1,233      526
Deferred tax liabilities
   Amortization and depreciation                                                                          (593)    (526)
                                                                                                          $640      $--
                                                                                                        -------   ------


         Income tax expense (benefit) consists of the following (in thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Current
   Federal                                                                                                $640    $--
   State                                                                                                    98     --
   Foreign                                                                                                  31    171
                                                                                                           769    171
Deferred
   Federal                                                                                                (640)    --
   State                                                                                                    --     --
                                                                                                          (640)    --
                                                                                                          $129   $171
                                                                                                          ----   ----


         A reconciliation of our effective tax rate to the federal statutory
tax rate of 34% follows (in thousands):



                                                                                                            APRIL 30,
                                                                                                          ------------
                                                                                                          2000    1999
                                                                                                          ----    ----
                                                                                                            
Expected tax (benefit) at federal statutory rate                                                          $958    $(799)
State taxes net of federal benefit                                                                          98     (104)
Foreign income taxed at different rates                                                                    (77)      26
Non-deductible expenses..............................................................                       67       84
Utilization of previously unrecognized net operating loss and tax credit carryforwards                    (115)      --
Change in valuation allowance                                                                             (802)   1,097
Other                                                                                                       --     (133)
                                                                                                          $129     $171
                                                                                                          ----     ----






NOTE 6--DEBT AND LINE OF CREDIT

         At April 30, 1999, we had amounts owing to our primary lender, along
with other secured and unsecured debt, amounting to $1,136,000. We also had
borrowings amounting to $922,000 payable to related parties. We repaid all of
these borrowings, except for certain term debt with an outstanding balance of
$20,000 at April 30, 2000, with the proceeds from the sale of our depleted
zinc business. We currently have no lending facilities with any financial
institutions, except for an unsecured line of credit available to Chemotrade
in the amount of DM 400,000 ($187,000). At April 30, 2000, there are no
borrowings outstanding under this line of credit.

NOTE 7--STOCKHOLDERS' EQUITY

COMMON STOCK

         On September 22, 1997, we completed an initial public offering of
810,000 units, each unit consisting of one share of common stock and one
redeemable common stock purchase warrant. Each warrant entitles the holder to
purchase one share of common stock at $5.80 per share, exercisable until
September 21, 2001. We may redeem the warrants at a price of $0.10 per
warrant if the closing price of our common stock is at least $14.50 per share
for 20 consecutive trading days.

         In connection with the offering, we granted the underwriter warrants
to purchase up to 160,000 shares of common stock at a weighted average
exercise price of $7.77. The warrants granted to the underwriter are
exercisable at anytime until September 1, 2002.

PREFERRED STOCK

         On July 29, 1999, we completed a private placement financing to
accredited investors and certain creditors valued in total at approximately
$2,745,000. We issued 1,830,000 units, each consisting of one share of Series
A Convertible Preferred Stock and one warrant. We received $2,250,000 in cash
proceeds and converted $425,000 of long-term debt in connection with the
private placement. Each share of the Series A Convertible Preferred Stock is
convertible into one share of our Common Stock. The liquidation preference
for the Series A Convertible Preferred Stock is $1.50 per share, amounting to
a total liquidation preference of $2,745,000 at April 30, 2000. Each warrant
allows the investor to purchase one share of Isonics Common Stock for $3.75
through July 29, 2002. We granted certain registration rights to the holders
of the shares of common stock underlying the Class A Convertible Preferred
Stock and the warrants.

         In addition to converting $425,000 of existing debt into equity as
part of the private placement we:

         -        Issued 500,000 warrants to purchase shares of our Common Stock
                  to an investment banker as a commission on this placement. The
                  warrants are exercisable at $3.75 per share through July 29,
                  2002.

         -        Issued 46,667 units in satisfaction of all current and future
                  obligations under the Isoserve royalty agreement.

         -        Extended the payment due date for the remaining balance on the
                  Chemotrade acquisition note to July 2000, which note has been
                  paid in full.

         -        Extended the payment due date for certain unsecured promissory
                  notes to January 2000, which notes have been paid in full.



STOCK OPTION AND PURCHASE PLANS

1996 STOCK OPTION PLAN

         Our 1996 Stock Option Plan authorized the grant of incentive and
nonqualified stock options to our key employees, directors or consultants.
The options generally expire ten years from the date of grant. In September
1997, the Board of Directors terminated the 1996 Stock Option Plan. As of
April 30, 2000, there remain 488,356 options outstanding under the 1996 Stock
Option Plan.

DIRECTORS' STOCK OPTION PLAN

         The 1998 Directors' Plan (the "Directors' Plan") provides that each
person serving as a member of the Board, who is not an employee of Isonics,
receive options to purchase 20,000 shares of Isonics Common Stock when such
person accepts the position as a Director and to receive an additional option
to purchase 10,000 shares when such person is re-elected as a Director
provided such person is not an employee of Isonics at the time of election.
The exercise price for the options is the fair market value on the date of
grant and the options are exercisable for five years from such date. The
options granted under the Directors' plan vest immediately. In the event a
Director resigns or is not re-elected to the Board, failure to exercise the
options within three months results in the options' termination. Although the
Directors adopted the plan in 1998, the Board formalized the plan by
resolution in January 2000.

         As of April 30, 2000, options to purchase a total of 110,000 shares
were outstanding under the Directors' Plan. We do not have any other
arrangements under which we compensate the Directors for acting in their
capacities as Directors.

EXECUTIVE AND INCENTIVE STOCK OPTION PLANS

         In November 1996, the Board of Directors adopted the Executive and
Incentive Stock Option Plans authorizing the granting of up to 570,000 and
150,000 incentive and nonqualified stock options to our key employees,
directors, or consultants. Incentive stock options are granted at a price not
less than fair market value, and nonqualified stock options are granted at a
price not less than 85% of the fair market value. Options are exercisable
when vested, typically over five years, and expire ten years after the date
of grant. As of April 30, 2000, options to purchase a total of 488,408 shares
were outstanding under the Executive and Incentive Stock Option Plans.

EMPLOYEE STOCK PURCHASE PLAN

         The employee stock purchase plan has reserved 200,000 shares of our
common stock for sale to all permanent employees who have met minimum
employment criteria. Employees who do not own 5% or more of the outstanding
shares are eligible to participate through payroll deductions. At the end of
each offering period, shares are purchased by the participants at 85% of the
lower of the fair market value of our Common Stock at the beginning or the
end of the offering period. As of April 30, 2000, 13,723 shares have been
issued under the plan.

PRO FORMA DISCLOSURE OF COMPENSATION EXPENSE UNDER SFAS NO. 123

         The exercise price of options granted generally approximates the
fair market value per share of our stock on the date of grant. Accordingly,
no compensation cost has been recognized for grants from the plans made to
employees or directors. Had compensation cost for grants to employees and
directors been determined based on the fair value of the options at the grant
dates consistent with SFAS No. 123, ACCOUNTING FOR STOCK-BASED COMPENSATION,
our results of operations and per share amounts for the years ended April 30,
2000 and 1999, would have been changed to the pro forma amounts indicated
below.




                                                                                  2000             1999
                                                                                  ----             ----
                                                                                           
Net income (loss)
   As reported                                                                  $2,689,000       $(2,521,000)
   Pro forma                                                                     1,248,000        (3,174,000)
Income (loss) per share--diluted
   As reported                                                                       $0.26            $(0.41)
   Pro forma                                                                          0.12             (0.51)


         The fair value of each option grant is estimated on the date of
grant using the Black-Scholes options-pricing model with the following
weighted average assumptions; no expected dividends, volatility of 150%;
risk-free interest rate of 6.0%; and expected lives of five (5) years. A
summary of the status of our stock option plans as of April 30, 2000 and
1999, and changes during the years ending on these dates is presented below.


                                                                                                  NUMBER OF     WEIGHTED
                                                                                                     SHARES      AVERAGE
                                                                                                                EXERCISE
                                                                                                                   PRICE
                                                                                                  ---------     --------
                                                                                                          
Outstanding, May 1, 1998                                                                          1,054,809        $1.84
   Granted                                                                                          480,721        $1.71
   Exercised                                                                                      (195,830)        $0.66
   Canceled                                                                                       (343,123)        $3.35
Outstanding, April 30, 1999                                                                         996,577        $1.49
   Granted                                                                                          169,500        $6.35
   Exercised                                                                                       (21,813)        $1.16
   Canceled                                                                                        (57,500)        $1.69
Outstanding, April 30, 2000                                                                       1,086,764        $2.25
                                                                                                 ----------




         The weighted average fair value of options granted during the years
ended April 30, 2000 and 1999 was $5.78 and $1.56, respectively.





Isonics Corporation and Subsidiaries NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

NOTE 7--STOCKHOLDERS' EQUITY

         The following information applies to options outstanding at April
30, 2000:



RANGE OF                                                WEIGHTED                                         WEIGHTED
RANGE OF                                                 AVERAGE                                          AVERAGE
EXERCISE                                     NUMBER     EXERCISE            NUMBER            NUMBER     EXERCISE
PRICE                                   OUTSTANDING        PRICE       OUTSTANDING       EXERCISABLE        PRICE
- --------                                -----------     --------       -----------       -----------     --------
                                                                                          
   $0.58                                    336,927        $0.58                 6           336,927        $0.58
$1.00-- $1.44                               204,783        $1.27                 9           149,783        $1.34
$1.62-- $2.38                               208,054        $1.90                 8            91,050        $1.88
$2.56-- $3.50                               180,000        $2.98                 8           125,000        $3.16
$5.56-- $7.31                               157,000        $6.72                 5           157,000        $6.72
                                          1,086,764        $2.25                             859,760        $2.35
                                          ---------                                         --------


NOTES RECEIVABLE FROM SHAREHOLDERS

         In fiscal 1997, two of our executive officers exercised stock
options to each acquire 259,175 shares of common stock at an exercise price
of $0.64 per share. In fiscal 1999, two other executive officers exercised
stock options to acquire 57,603 and 138,227 shares of common stock at
exercise prices of $0.87 and $0.58, respectively. In each case, we loaned the
executive officer the aggregate amount representing the exercise price of the
option, and the officer executed a promissory note reflecting the loan. Each
executive officer pledged the purchased shares as collateral for the loan
pursuant to a pledge agreement. Each loan bears interest at an annual rate
equal to the minimum applicable federal rate, and interest is payable
annually; principal and accrued but unpaid interest is due five years from
the date of the note. Until each note has been paid in full and upon any sale
of such option shares by the respective executive, a portion of the sales
proceeds will be used to pay amounts owed under the note. In addition, during
fiscal 1998, we loaned to each of the two executive officers related to the
fiscal 1997 option exercises, pursuant to a five-year note with interest at
the minimum applicable federal rate, the amount equal to the federal and
state tax liability incurred by him as a result of exercising such option,
and agreed to pay compensation to such officers equal to the amount of
interest payable under these loans and the amount of taxes payable as a
result of such compensation. At April 30, 1999, principal and interest due on
the loans to acquire the common stock totaled $460,000 and $9,000,
respectively, and, principal and interest on the loans to pay the federal and
state tax liabilities totaled $126,000 and $4,000, respectively.

         In January 2000, the Board of Directors agreed to forgive the
current interest and principal due related to the tax notes and to accept
Isonics Common Stock, owned by the officers, in payment of the balances owed
for the share purchase loans. The amount owed by Mr. James Alexander, our
President and CEO, that was forgiven was $74,000. The amount owed by Mr.
Boris Rubizhevsky, our Senior Vice President, that was forgiven was $61,000.
In both cases the amount forgiven was treated as bonus compensation to Mr.
Alexander and Mr. Rubizhevsky. Each officer surrendered 30,437 shares of
Isonics Common Stock to pay off $175,000 of principal and accrued interest.
The other two loans, executed in fiscal 1999, were paid in full: the first,
in cash, in March 2000; and the second, by the surrender of 11,664 shares of
our Common Stock in January 2000. As of April 30, 2000 we had no notes
receivable outstanding for the acquisition of stock.




WARRANTS

         In addition to the warrants issued as part of our initial public
offering, we have issued warrants in connection with debt offerings and a
private placement of convertible preferred stock, and as consideration for
concessions from lenders and vendors. A summary of the activity in our warrants
follows:



                                                                                                                WEIGHTED
                                                                                                                 AVERAGE
                                                                                                  NUMBER OF     EXERCISE
                                                                                                     SHARES        PRICE
                                                                                                 ----------    ---------
                                                                                                         
Outstanding, May 1, 1998                                                                          2,462,029        $3.81
   Warrants issued with debt                                                                         75,000         2.51
   Exercised                                                                                       (94,559)         0.18
   Expired                                                                                               --         0.00
Outstanding, April 30, 1999                                                                       2,442,470        $3.90
   Warrants issued in debt restructuring                                                             95,000         2.61
   Warrants issued in private placement of convertible preferred stock                            2,330,000         3.75
   Warrants issued for isotope supply agreement                                                   4,000,000         3.75
   Exercised                                                                                    (3,897,173)         3.55
   Forfeited, via net exercise                                                                  (1,043,650)         3.92
   Expired                                                                                               --         0.00
Outstanding, April 30, 2000                                                                       3,926,647        $4.01
                                                                                                 ----------




         In fiscal 1999 we issued two unsecured promissory notes bearing
interest at prime plus 4% for $200,000 each to a vendor and an unaffiliated
party. The two $200,000 notes were due in April 1999. The Company issued
50,000 warrants each to the vendor and the unaffiliated party. The fair value
of these warrants, $144,000, was recorded as additional interest expense. The
unaffiliated party converted its $200,000 unsecured promissory note into
133,000 shares of convertible preferred stock and 133,000 warrants as
described above under "PREFERRED STOCK."

         In July 1999, we made a principal payment of $550,000 towards the
amounts owing to the former Chemotrade shareholders from the acquisition of
Chemotrade. At that time, we extended the due date of the balance to July 31,
2000. In consideration for the extension, we issued 70,000 warrants to the
former Chemotrade shareholders, exercisable at $3.00 per warrant until June
30, 2004. We recognized a charge amounting to $157,000 representing the fair
value of the warrants issued determined using the Black-Scholes option
pricing model.

         In conjunction with the sale of our depleted zinc business to
Eagle-Picher, we agreed that Eagle-Picher will sell to us 200 kilograms of
silicon-28 in consideration for warrants to purchase 4,000,000 shares of our
common stock at a purchase price of $3.75 per share, exercisable for
forty-two months. Eagle-Picher exercised the warrants in March 2000 under a
'net-exercise' provision entitling Eagle-Picher to receive 3,130,435 shares
of common stock. These shares are subject to a prorated reduction to the
extent Eagle-Picher does not deliver the required 200 kilograms of silicon-28
in calendar 2000. Accordingly, these contingent shares are excluded from the
number of shares used for calculating basic net income per share. The shares
issued are subject to a registration rights agreement. Eagle-Picher claims
that we should issue to them an additional 155,279 shares pursuant to the net
exercise provision, but we believe their calculation is in error, and we are
continuing discussions with representatives of Eagle-Picher to resolve this
dispute.

         On June 13, 2000, we offered to the holders of the outstanding
warrants issued in our public offering (the "Class A Warrants") the
opportunity to exchange their Class A Warrants for Class B Warrants. The
exercise price for the Class B Warrants, $5.80 per share, is the same as that
of the Class A Warrant. If a Class B Warrant is



exercised before its expiration date (September 30, 2000), we will issue one
share of Common Stock and one Class C Warrant. The Class C Warrants expire
June 15, 2003, are exercisable for one share of Common Stock at a price of
$10.00 per share, and are redeemable if our Common Stock trades at or above
$15.00 per share for any 20 of 30 consecutive trading days.

         We have reserved shares of common stock for issuance as follows:


                                                                                                    APRIL 30,
                                                                                                         2000
                                                                                                    ---------
                                                                                                 
Exercise of stock options                                                                           1,296,543
Exercise of warrants                                                                                3,926,647
Employee stock purchase plan                                                                          186,277
Convertible preferred stock                                                                         1,830,000
                                                                                                    7,239,467
                                                                                                    ---------




NOTE 8--BUSINESS SEGMENTS AND FOREIGN OPERATIONS

         We have two operating segments: Isotope Production and Contract
Research and Development. Our reportable segments are strategic business
units that offer different products and services. They are managed based on
the fundamental differences in their operations.

         Information by segment is set forth below (in thousands):


                                                                                                        2000        1999
                                                                                                        ----        ----
                                                                                                           
Net revenues
   Isotope Production                                                                                $11,577     $14,384
   Contract Research and Development                                                                   1,156       2,614
Operating income (loss)
   Isotope Production                                                                                $(2,070)    $(1,035)
   Contract Research and Development                                                                    (331)       (831)
Identifiable assets
   Isotope Production                                                                                 $8,711      $5,713
   Contract Research and Development                                                                     822       1,093


         A summary of our operations by geographic area is presented below
(in thousands):


                                                                                                        2000        1999
                                                                                                        ----        ----
                                                                                                          
Net revenues
   United States                                                                                      $4,501      $6,817
   Germany                                                                                             8,232      10,181
Operating income (loss)
   United States                                                                                     $(2,486)    $(2,322)
   Germany                                                                                                85         456
Identifiable assets
   United States                                                                                      $8,117      $5,507
   Germany                                                                                             1,416       1,299


NOTE 9--PROFIT SHARING PLAN

         We have a profit sharing plan qualified under section 401(k) of the
Internal Revenue Code. The plan is a defined contribution plan, covering
substantially all of our employees. Company contributions to the plan
aggregated approximately $40,000 and $30,000 for 2000 and 1999, respectively.

NOTE 10--CONCENTRATIONS

         Two customers accounted for approximately 15% and 10% of net
revenues for the year ended April 30, 2000. One of these customers accounted
for 18% of accounts receivable at April 30, 2000. Two separate customers
accounted for 23% and 13% of net revenues for the year ended April 30, 1999.
Accounts receivable at April 30, 1999, did not include any amounts due from
either of these two customers.

NOTE 11--RESTRUCTURING

         In the year ended April 30, 1999, we recorded a charge to operations
amounting to $691,000 relating to a planned restructuring of our operations.
This charge consisted primarily of lease termination costs of $132,000,
severance pay for terminated employees of $91,000, and the write down of
fixed assets of $468,000. As of April 30, 2000, we had completed the
restructuring. The only costs remaining to be paid, which have been accrued,
relate to the lease payments of approximately $47,000 on our former
facilities in excess of the sublease income.







NOTE 12--COMMITMENTS

         We rent office, production facilities, and equipment under operating
leases expiring through March 2004. Rent expense for operating leases was
approximately $224,000 and $202,000 for the years ended April 30, 2000 and
1999, respectively. Future minimum annual operating lease commitments are as
follows (in thousands):



YEAR ENDING APRIL 30,
- ---------------------
                                                                                                      
        2001                                                                                             $163
        2002                                                                                               40
        2003                                                                                               16
        2004                                                                                                8
                                                                                                         $227
                                                                                                         ----


         On December 1, 1999, we signed a ten-year supply agreement with
Eagle-Picher by which we will have the exclusive right to purchase quantities
of isotopically pure silicon-28, silicon-29, and silicon-30, and a
non-exclusive right to purchase quantities of isotopically pure carbon-12 and
carbon-13 produced by Eagle-Picher from its Oklahoma-based facilities. We
agreed to pay Eagle-Picher a fee equal to 3% of the net revenues from all
sales made by us of products incorporating the enriched silicon isotopes
supplied by Eagle-Picher. As of April 30, 2000, no royalties have accrued
under this agreement.







Isonics Corporation and Subsidiaries CONDENSED CONSOLIDATED BALANCE SHEETS
(in thousands, except share amounts)

                                        ASSETS



                                        ASSETS
                                                                              (Unaudited)
                                                                           October 31, 2000
                                                                       ----------------------       ------------------
                                                                                              
CURRENT ASSETS:
     Cash and cash equivalents                                         $                1,082       $
     Accounts receivable (Net of allowance of $308                                        637
     Notes receivable                                                                     458
     Income taxes receivable                                                              426
     Inventories                                                                          280
     Prepaid expenses and other current assets                                             90
     Deferred income taxes, current                                                        53
                                                                       ----------------------       ------------------
          Total current assets                                                          3,026
                                                                       ----------------------       ------------------

LONG-TERM ASSETS
     Property and equipment, net                                                          506
     Goodwill, net                                                                      2,977
     Notes receivable from shareholders
     Deferred income taxes                                                                492
     Other assets                                                                          32
                                                                       ----------------------       ------------------
          Total long-term assets                                                        4,007
                                                                       ----------------------       ------------------

TOTAL ASSETS                                                           $                7,033       $
                                                                       ======================       ===================

                        LIABILITIES AND SHAREHOLDERS' EQUITY

                                                                              (Unaudited)
                                                                           October 31, 2000
                                                                       ----------------------       ------------------
CURRENT LIABILITIES:
     Notes payable and line of credit                                  $                   17       $
     Accounts payable                                                                     534
     Accrued liabilities                                                                  744
     Income taxes payable                                                                   6
                                                                       ----------------------       ------------------
          Total current liabilities                                                     1,301
                                                                       ----------------------       ------------------
SHAREHOLDERS' EQUITY:
     Class A Preferred Stock--no par value.  10,000,000
          shares authorized; 1,180,333 shares issued and
          outstanding
                                                                                        1,770
     Common stock--no par value.  20,000,000 shares
          authorized; 11,455,826 shares issued and outstanding

                                                                                        7,999
     Deferred compensation                                                              (112)
     Accumulated deficit                                                              (3,925)
                                                                       ----------------------       ------------------
          Total shareholders' equity                                                    5,732
                                                                       ----------------------       ------------------
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY                             $                7,033       $
                                                                       ======================       ===================



                  See notes to condensed consolidated financial statements.







Isonics Corporation and Subsidiaries CONDENSED CONSOLIDATED STATEMENTS OF
OPERATIONS (in thousands, except per share data) (Unaudited)


                                                      Three Months Ended                        Six Months Ended
                                                          October 31,                              October 31,
                                                ---------------------------------      -----------------------------------
                                                      2000                1999                2000                1999
                                                -------------       -------------       -------------       --------------
                                                                                                
Net revenues                                    $       1,955       $       4,460       $       3,991       $        7,544
Cost of revenues                                        1,550               3,469               3,071                5,868
                                                -------------       -------------       -------------       --------------
          Gross margin                                    405                 991                 920                1,676

Operating expenses:
     Selling, general and administrative                1,780                 945               2,980                1,830
     Research and development                             412                 205                 716                  332
     Restructuring and office closure                      --                  --                  --                   66
                                                -------------       -------------       -------------       --------------
          Total operating expenses                      2,192               1,150               3,696                2,228
                                                -------------       -------------       -------------       --------------

Operating loss                                        (1,787)               (159)             (2,776)                (552)
                                                -------------       -------------       -------------       --------------

Other income (expense):
     Foreign exchange                                    (57)                 (4)                  11                   --
     Interest and other income                            109                 121                 208                  162
     Interest expense                                    (10)               (101)                (26)                (225)
                                                -------------       -------------       -------------       --------------
          Total other income (expense), net                42                  16                 193                 (63)
                                                -------------       -------------       -------------       --------------
Loss before income taxes                              (1,745)               (143)             (2,583)                (615)
Income tax expense (benefit)                              (1)                  --                  --                    1
                                                -------------       -------------       -------------       --------------
NET LOSS                                        $     (1,744)       $       (143)       $     (2,583)       $        (616)

Net loss per share--basic and diluted
Net loss per share                              $      (0.21)       $      (0.02)       $      (0.33)       $       (0.09)
Shares used in computing per share
     Information                                        8,112               6,608               7,878                6,608



                 See notes to condensed consolidated financial statements.







Isonics Corporation and Subsidiaries CONDENSED CONSOLIDATED STATEMENTS OF CASH
FLOWS (in thousands) (Unaudited)


                                                                                 Six Months Ended October 31,
                                                                       ----------------------------------------------------
                                                                               2000                         1999
                                                                       ----------------------       ----------------------
                                                                                              
Net cash (used in) operating activities                                $              (2,495)       $              (1,385)

CASH FLOWS FROM INVESTING ACTIVITIES:
     Purchases of property and equipment                                                 (21)                           --
                                                                       ----------------------       ----------------------
          Cash used in investing activities                            $                 (21)       $                   --
                                                                       ----------------------       ----------------------

CASH FLOWS FROM FINANCING ACTIVITIES:
     Net change in line of credit                                                          --                        (298)
     Proceeds from issuance of notes payable                                               --                           75
     Repayments of notes payable                                                          (3)                        (781)
     Proceeds from issuance of common stock                                               216                           --
     Proceeds from issuance of Class A Preferred Stock                                     --                        2,250
                                                                       ----------------------       ----------------------
          Cash provided by financing activities                        $                  213       $                1,246
                                                                       ----------------------       ----------------------

NET DECREASE IN CASH AND CASH
     EQUIVALENTS:                                                                     (2,303)                        (139)
     Cash and cash equivalents at beginning of period                                   3,385                          452
                                                                       ----------------------       ----------------------
     Cash and cash equivalents at end of period                        $                1,082       $                  313
                                                                       ======================       ======================

Supplemental disclosure of cash flow information: Cash paid during the period
     for:
          Interest                                                     $                    1       $                  186
                                                                       ======================       ======================
          Income taxes                                                 $                   --       $                    1
                                                                       ======================       ======================

Supplemental disclosure of noncash investing and financing activities:
          Accounts payable converted into notes payable                $                   --       $                  243
          Liabilities converted into Class A Preferred Stock                               --                          495
          Issuance of warrants in conjunction with notes payable                           --                          157
          Class A Preferred Stock converted into Common Stock                             975                           --
                                                                       ======================       ======================




            See notes to condensed consolidated financial statements.




                      ISONICS CORPORATION AND SUBSIDIARIES
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS


BASIS OF PRESENTATION

The accompanying condensed consolidated financial statements of Isonics
Corporation and Subsidiaries (the "Company" or "Isonics") as of October 31,
2000, and for the three months and six months ended October 31, 2000, and
1999, have been prepared on the same basis as the annual audited financial
statements. In the opinion of management, such unaudited information includes
all adjustments (consisting only of normal recurring accruals) necessary for
a fair presentation of this interim information. Operating results and cash
flows for interim periods are not necessarily indicative of results for the
entire year. The information included in this report should be read in
conjunction with our audited financial statements and notes thereto included
in our Annual Report on Form 10-KSB for the year ended April 30, 2000.

NET INCOME (LOSS) PER SHARE

Net income (loss) per share is based on the weighted average number of common
shares and potentially dilutive securities outstanding during the period.
Potentially dilutive securities consist of the incremental common shares
issuable upon conversion of preferred stock (using the "if converted" method)
and shares issuable upon the exercise of stock options and warrants (using
the "treasury stock" method). Potentially dilutive securities are excluded
from the computation of net income (loss) per share if their effect is
anti-dilutive. Accordingly, as of October 31, 2000, a total of approximately
4,921,646 outstanding stock options and warrants, and 1,180,333 outstanding
Class A Convertible Preferred Stock shares have been excluded from the
diluted net income (loss) per share calculation, as the inclusion would be
anti-dilutive. Accordingly, as of October 31, 1999, a total of approximately
5,794,047 outstanding stock options and warrants, and 1,830,000 outstanding
Class A Convertible Preferred Stock shares have been excluded from the
diluted net income (loss) per share calculation, as their inclusion would be
anti-dilutive.

Contingently issued shares are included in the computation when the related
conditions are satisfied. Accordingly, as of October 31, 2000, 3,130,435
shares of Common Stock were excluded from the net income (loss) per share
calculation, as the issuance of this Common Stock is contingent upon the
delivery of silicon-28 per the terms of the Eagle-Picher transaction, as
described in the paragraph titled "SALE OF DEPLETED ZINC BUSINESS," under
Management's Discussion and Analysis. Eagle-Picher disputes our calculation
and believes we should issue to it an additional 155,279 shares of Common
Stock. We believe Eagle-Picher's calculation is in error and we are
continuing discussions with representatives of Eagle-Picher to resolve this
matter. These disputed shares have also been excluded from the earnings per
share calculation, as they have not been issued.

During the six month period ended October 31, 2000, we issued the following
shares of Common Stock:


                        DESCRIPTION                                       NUMBER OF COMMON STOCK SHARES
                        -----------                                       -----------------------------
                                                                       
Balance as of April 30, 2000                                                                               10,492,931
Exercise of options for cash                                                                                  185,912
Conversion of Class A Preferred Stock                                                                         313,333
Issuance for services                                                                                           4,000
ESPP issuances                                                                                                  7,484
                                                                                                                -----
Balance as of July 31, 2000                                                                                11,003,660
Exercise of options for cash                                                                                   16,500
Conversion of Class A Preferred Stock                                                                         336,334
Surrender of Warrants for Common Stock                                                                         99,332
                                                                                                               ------
Balance as of October 31, 2000                                                                             11,455,826



INVENTORIES

Inventories consist of (in thousands):


                                                                         October 31, 2000
                                                                       ---------------------
                                                                    
Finished goods                                                         $                  156
Work in progress                                                                          124
                                                                                          ---
     Total inventories                                                 $                  280









                           ISONICS CORPORATION AND SUBSIDIARIES
             NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)


SIGNIFICANT CUSTOMERS

At October 31, 2000, four customers accounted for 56.3% of total accounts
receivable. These four customers, plus a fifth customer accounted for
approximately 42.6% of net revenues during the three months ended October 31,
2000. These same five customers accounted for approximately 45.4% of net
revenues during the six months ended October 31, 2000. A different customer
accounted for approximately 17% of net revenues during the three months ended
October 31, 1999, and the same customer accounted for approximately 10% of
net revenues during the six months ended October 31, 1999.






                          ISONICS CORPORATION AND SUBSIDIARIES
             NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)


SEGMENT INFORMATION (IN THOUSANDS)


                                                      Three Months Ended                        Six Months Ended
                                                          October 31,                              October 31,
                                                ---------------------------------       ----------------------------------
                                                      2000                1999                2000                1999
                                                -------------       -------------       ------------        --------------
                                                                                                
Segment revenues:
     Isotope products                           $       1,955       $       4,076       $       3,991       $        6,827
     Contract research and development
          services and other                               --                 384                  --                  717
                                                -------------       -------------       ------------        --------------
          Total                                 $       1,955       $       4,460       $       3,991       $        7,544









                             ISONICS CORPORATION AND SUBSIDIARIES
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)


                                                      Three Months Ended                        Six Months Ended
                                                          October 31,                              October 31,
                                                ---------------------------------       ----------------------------------
                                                      2000                1999                2000                1999
                                                -------------       -------------       ------------        --------------
                                                                                                
Segment operating (loss) income:
     Isotope products                           $     (1,787)       $        (28)       $     (2,776)       $        (329)
     Contract research and development
          services and other                               --               (131)                  --                (223)
                                                -------------       -------------       ------------        --------------
          Total                                 $     (1,787)       $       (159)       $     (2,776)       $        (552)





                                                     October 31, 2000
                                                ---------------------------
                                             
Total Assets:
     Isotope products                           $                     6,190
     Contract research and development
          services and other                                            843
                                                ---------------------------
          Total                                 $                     7,033



A summary of operations by geographic area is as follows:


                                                      Three Months Ended                        Six Months Ended
                                                          October 31,                              October 31,
                                                ---------------------------------       ----------------------------------
                                                      2000                1999                2000                1999
                                                -------------       -------------       ------------        --------------
                                                                                                
Net revenues:
     United States                              $         771       $       1,895       $       1,299       $        2,805
     Germany                                            1,184               2,565               2,692                4,739
                                                -------------       -------------       ------------        --------------
          Total                                 $       1,955       $       4,460       $       3,991       $        7,544




                                                      Three Months Ended                        Six Months Ended
                                                          October 31,                              October 31,
                                                ---------------------------------       ----------------------------------
                                                      2000                1999                2000                1999
                                                -------------       -------------       ------------        --------------
                                                                                                
Operating (loss) income:
     United States                              $     (1,766)       $       (275)       $     (2,637)       $        (724)
     Germany                                             (21)                 116               (139)                  172
                                                -------------       -------------       ------------        --------------
          Total                                 $     (1,787)       $       (159)       $     (2,776)       $        (552)









                             ISONICS CORPORATION AND SUBSIDIARIES
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)




                                                     October 31, 2000
                                                ---------------------------
                                             
Total Assets:
     United States                              $                     5,780
     Germany                                                          1,253
                                                ---------------------------
          Total                                 $                     7,033











                                 ISONICS CORPORATION
                                LETTER OF TRANSMITTAL

         To accompany certificates representing Class A Warrants to acquire
shares of common stock of Isonics Corporation, surrendered in exchange for
certificates representing Class B Warrants; each Class B Warrant is
exercisable for one share of common stock and one Class C Warrant to purchase
shares of Isonics common stock. Please follow carefully the instructions
below. You must deliver this transmittal letter, properly completed and
signed, together with your original warrant certificate to the Exchange Agent
not later than the close of business in New York City on April 30, 2001.

To: Continental Stock Transfer & Trust Company, Exchange Agent

     By US Postal Service or Overnight Courier:        By Hand Delivery:
                                               -------                  -------
                  Continental Stock Transfer & Trust Company
                  Exchange Agent for Isonics Corporation
                  2 Broadway
                  New York, New York 10004

Ladies and Gentlemen:

         In connection with the offer by Isonics Corporation ("Isonics") to
issue Class B Warrants, each exercisable for one share of common stock and
one Class C Warrant to purchase shares of common stock of Isonics registered
under the Securities Act of 1933 in exchange for Class A Warrants of Isonics,
(the "Exchange Offer"), the undersigned hereby surrenders for exchange the
warrant certificate(s) identified below representing Class B Warrants to
purchase shares of common stock of Isonics. (IF I AM EXERCISING THE CLASS B
WARRANTS AT THE SAME TIME I AM SUBMITTING THE CLASS A WARRANTS FOR EXCHANGE,
I UNDERSTAND THAT I MUST ALSO COMPLETE THE INFORMATION RELATING TO THE
EXERCISE OF THE WARRANT ON THE REVERSE SIDE OF THIS LETTER OF TRANSMITTAL.)



               Name(s) and Address of Registered Owner(s)                 Certificate(s) Surrendered        Number of Warrants
                    As They Appear on Certificate(s)                                                      Represented by Warrant
                                                                                                        Certificate(s) and Exercise
                                                                                                              Price per Share
                                                                                                  







                                                                                Total Warrants


         The undersigned represents that he/she has full authority to
surrender the certificate(s) identified above and that except for the
restrictions under the Securities Act of 1933, the Class A Warrants
represented by such certificate(s) are free and clear of all liens,
restrictions, charges, and encumbrances and not subject to any adverse
claims. The undersigned will, upon request, execute any additional documents
necessary to complete the surrender of the Class B Warrants represented by
such certificate(s). All authority conferred or agreed to be conferred in
this Letter of Transmittal shall be binding upon the successors, assigns,
heirs, executors, administrators and legal representatives of the undersigned
and shall survive and not be affected by the death or incapacity of the



undersigned. The undersigned hereby acknowledges that delivery of the
certificate(s) identified above shall be affected, and risk of loss and title
to such certificate(s) shall pass, only upon proper delivery thereof to you.

         Please issue a Class B Warrant in the name(s) shown in the box above
and deliver such certificates and check by mail to the address shown in the box
above UNLESS contrary instructions are given in the box below.

         EXERCISE OF CLASS B WARRANT: If there is a current prospectus for the
exercise of Class B Warrants, you may choose to exercise the Class B Warrants to
be issued in exchange for the Class A Warrants at the same time you are
submitting the Class A Warrants for exchange. To do so, you must initial and
follow the instructions given below:

                                    I hereby elect to exercise all Class B
                                    Warrants to be issued in exchange for the
                                    Class A Warrants I am surrendering for
                  -----             exchange;

                                    I hereby tender the Class B Warrant
                                    certificates to be issued in exchange for
                  -----             the Class A Warrants;

                                    I hereby tender the exercise price of the
                                    Class B Warrants (calculated by multiplying
                                    the number of Class B Warrants being
                                    exercised times $1.50 per share) in a check
                  -----             made payable to Isonics Corporation.

         I understand that the exercise is effective as of the date this
Letter of Transmittal and all other required documents are received by the
Exchange Agent provided that: all required documents are included; all
required signatures have been included and signatures have been properly
guaranteed; good funds are tendered; and I am a resident of a jurisdiction
where the exercise of the Class B Warrants has been qualified under state
law. If I am tendering a check, I understand that I must wait until the funds
are cleared before any certificates will be issued.
- ------------------------------------------------------------------------------

                      SPECIAL DELIVERY INSTRUCTIONS

         Fill in ONLY if delivery of the certificates representing the Class B
Warrants is to be mailed to an address OTHER than that appearing in the box
above. Please see instruction 3.

                  Mail or deliver Certificate to:

                  Name:
                        ---------------------------
                  (Please Print)

                  Address:
                          --------------------------
                  -----------
                  (Include Zip Code)

- ------------------------------------------------------------------------------

           ALL SHAREHOLDERS MUST SIGN IN THE SPACE PROVIDED BELOW



                                                         X
                                            (Signatures of Shareholders)

                                             Title:
                                             Name(s):


                                                          X


                                              (Please Print)

Daytime Telephone Number
(including Area Code)
Must be signed by registered holder(s) exactly as name(s) appear(s) on
certificate(s). If signed by an officer of a corporation or others acting in
a fiduciary or representative capacity, please provide the following
information. See Instructions 2 and 5.

                                                       MEDALLION
                                               GUARANTEE OF SIGNATURE(S)

(See instruction 4)

                                                      Name of firm:
                                                  Authorized Signature:



                                                                           
     SUBSTITUTE                PART 1 Taxpayer Identification No.--For           Part II For Payee Exempt
      FORM W-9                 All Accounts From Backup Withholding


                               Enter your taxpayer identification number
                               in the appropriate box.  For most
 Payer's Request for Taxpayer  individuals, this is your social security         Social Security Number
         Identification Number number.  OR
                                                                                 Employer Identification Number


             Certification-Under penalties of perjury, I certify that:
(1)  The number shown on this form is my correct taxpayer identification
     number, or I am waiting for a number to be issued to me and either (a) I
     have mailed or delivered an application to receive a taxpayer
     identification number to the appropriate Internal Revenue Service Center
     or Social Security Administration Office or (b) I intend to mail or
     deliver an application in the near future. I understand that if I do not
     provide a taxpayer identification number within sixty (60) days, 31% of
     all reportable payments made to me thereafter will be withheld until I
     provide a number.

(2)  I am not subject to backup withholding either because (a) I am exempt
     from backup withholding, or (b) I have not been notified by the Internal
     Revenue Service ("IRS") that I am subject to backup withholding as a
     result of a failure to report all interest or dividends, or (c) the IRS
     has notified me that I am no longer subject to backup withholding; and

(3)  Any other information provided on this form is true, correct and complete.
SIGNATURE:______________________ DATE:___________________ , 20__

     NOTE: FAILURE TO COMPLETE AND RETURN THIS FORM MAY RESULT IN BACKUP
WITHHOLDING OF 31% OF ANY PAYMENTS MADE TO YOU PURSUANT TO THE OFFER.



                                 INSTRUCTIONS

         Forming Part of the Terms and Conditions of this Letter of
Transmittal

         1. USE OF LETTER OF TRANSMITTAL. This Letter of Transmittal, duly
completed and signed, together with the surrendered certificates representing
restricted shares and warrants to purchase restricted shares and any other
documents required by these Instructions, should be sent by mail or overnight
courier or delivered by hand to the Exchange Agent at the address set forth
above. Delivery shall be affected, and risk of loss and title to the
certificates representing restricted shares and warrants to purchase
restricted shares shall pass, only upon actual delivery of such certificates
to the Exchange Agent. THE METHOD OF DELIVERY OF ALL DOCUMENTS IS AT THE
ELECTION AND RISK OF THE HOLDER. IF DELIVERY IS BY MAIL, REGISTERED MAIL WITH
RETURN RECEIPT REQUESTED, PROPERLY INSURED, IS RECOMMENDED. A return envelope
is enclosed for your convenience.

         2. SIGNATURES. The signatures on this Letter of Transmittal must
correspond exactly with the name(s) as written on the face of the surrendered
certificates. In the case of joint tenants, all should sign. If the
surrendered certificates are registered in different forms of the name of any
person signing this Letter of Transmittal (e.g. "John Smith" on one
certificate and "J. Smith" on another), it will be necessary for such person
either to sign this Letter of Transmittal in each way in which the
certificates are registered or to sign as many Letters of Transmittal as
there are different name registrations. When signing as an agent, attorney,
administrator, executor, guardian, trustee, or in any other fiduciary or
representative capacity, or as an officer of a corporation on behalf of the
corporation, please give your full name and title as such. If a certificate
is registered in the name of joint owners with right of survivorship and one
or more of the owners is deceased, the surviving owner(s) should sign the
Letter of Transmittal and furnish a letter providing information concerning
the death of the registered owner(s). It is only necessary to deliver to the
Exchange Agent a properly signed Letter of Transmittal, together with the
related surrendered certificates (it is not necessary to sign the back of
such stock certificates).

         3. DELIVERY OF CERTIFICATES AND CHECK TO A DIFFERENT ADDRESS. If a
certificate representing registered shares and/or warrants to purchase
registered shares or check for cash in lieu of fractional shares, if any, is
to be delivered to an address different from that appearing in the top box
above, please complete the "Special Delivery Instructions" box above.

         4. CORRECTION OF, OR CHANGE IN, NAME. For a correction of name, or
for a change in name which does not involve a change of ownership, proceed as
follows: (i) for a change in name by marriage, the surrendered certificates
and this Letter of Transmittal should be endorsed or signed, e.g., "Mary Doe,
now by marriage, Mary Jones" and (ii) for a correction in name, the
surrendered certificates and this Letter of Transmittal should be endorsed or
signed, e.g., "James E. Brown" incorrectly inscribed as "J.E. Brown." In such
event, the signature on this Letter of Transmittal reflecting such correction
or change must be guaranteed by a financial institution or brokerage firm
having membership in good standing, in a recognized guarantee program
[Securities Transfer Agents Medallion Program, New York Stock Exchange, Inc.
Medallion Program, or the Stock Exchanges Medallion Program (the "Programs")].
No guarantee will be accepted if the aggregate value of the transaction
exceeds the authorized limit as defined in the Program. Notaries Public
CANNOT execute acceptable guarantees of signatures.

         5. SUPPORTING EVIDENCE. In case any Letter of Transmittal,
certificate endorsement or stock power is executed by an agent, attorney,
administrator, executor, guardian, trustee, or in any other fiduciary or
representative capacity, or by an officer of a corporation on behalf of such
corporation, there should be submitted with the Letter of Transmittal and
surrendered certificates, documentary evidence of the authority of the person
making such execution to assign, sell and transfer shares. Such documentary
evidence of authority must be in the form satisfactory to the Exchange Agent.
See Instructions 8 and 9.

         6. LOST OR STOLEN STOCK CERTIFICATES. If certificates representing
restricted shares or warrants to purchase restricted shares have been lost or
stolen, the Exchange Agent should be contacted in writing. The letter should



include the certificate number(s) and number of shares/warrants that have
been lost or stolen along with the holder's name and address. The Exchange
Agent will forward affidavits for completion so that a bond or other
satisfactory indemnity can be obtained, and to make other arrangements so
that the lost certificates can be replaced and the shareholder may receive
certificates representing registered shares, certificates representing
warrants to purchase registered shares, and a check for cash in lieu of
fractional shares, if any, in exchange for such restricted shares and
warrants.

         7. MISCELLANEOUS. In the event that a surrender of certificates is
defective, the Exchange Agent shall attempt, in consultation with ISONICS, to
take such action as may be necessary to resolve promptly the irregularity,
and in that connection, the Exchange Agent may use its best efforts to
contact the appropriate capital shareholder by whatever means of
communication it deems most expedient. ISONICS shall have the absolute right
to reject any or all of such surrenders that are not in proper form and to
waive any defects in or conditions of such surrender.

       8. INQUIRIES. All inquiries with respect to the surrender of
certificates representing restricted shares or warrants in exchange for
certificates representing registered shares or warrants, and a check for cash
in lieu, if applicable, as well as requests for additional copies of this
Letter of Transmittal, should be made directly to Continental Stock Transfer
& Trust Company, Exchange Agent, at the address above or by telephoning
212-509-4000.