SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D. C. 20549



                                    FORM 8-K

                 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934



                DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED):
                                   MAY 22, 2001



                               GENZYME CORPORATION
             (Exact name of registrant as specified in its charter)




       MASSACHUSETTS                    0-14680                06-1047163
(State or other jurisdiction of     (Commission file         (IRS employer
 incorporation or organization)          number)         identification number)


               ONE KENDALL SQUARE, CAMBRIDGE, MASSACHUSETTS 02139
               (Address of Principal Executive Offices) (Zip Code)


               Registrant's telephone number, including area code:
                                 (617) 252-7500






ITEM 5.  OTHER EVENTS.

         As reported on our current report on Form 8-K dated April 25, 2001
(filed April 26, 2001), on April 25, 2001 we entered into an Agreement and
Plan of Merger with Focal, Inc. ("Focal") to effect a business combination
through the merger of a wholly-owned subsidiary of ours with and into Focal.
In addition, in May 2001 we entered into a stock purchase agreement with
Wyntek Diagnostics, Inc. ("Wyntek") and its stockholders, pursuant to which
Genzyme will acquire all or substantially all of the outstanding capital
stock of Wyntek for approximately $65.0 million in cash. We are filing this
report to include (1) the audited financial statements of Focal as of
December 31, 2000 and 1999 and for each of the three years in the period
ended December 31, 2000, including the report of independent auditors dated
January 31, 2001, (2) the unaudited financial statements of Focal as of and
for the three months ended March 31, 2001 and 2000 and (3) unaudited pro
forma combined financial information which describes the pro forma effect of
our planned acquisitions of Focal and Wyntek on the unaudited statements of
operations for the three months ended March 31, 2001 and the year ended
December 31, 2000 and the unaudited balance sheet as of March 31, 2001 of
both Genzyme Corporation and Genzyme Biosurgery, the division of Genzyme
Corporation to which the assets and liabilities and operations of Focal will
be allocated.

ITEM 7.     FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

(c)      Exhibits:

         2        Agreement and Plan of Merger, dated as of April 25, 2001,
                  among Genzyme Corporation, Sammy Merger Corp. and Focal, Inc.
                  Attached as Annex A to the proxy statement/prospectus
                  contained in Genzyme's registration statement on Form S-4 (No.
                  333-61296) filed with the SEC on May 21, 2001 and incorporated
                  herein by reference.

         23       Consent of Ernst & Young LLP.  Filed herewith.

         99.1     The audited financial statements of Focal as of December 31,
                  2000 and 1999 and for each of the three years in the period
                  ended December 31, 2000, including the report of independent
                  auditors dated January 31, 2001. Filed herewith.

         99.2     The unaudited financial statements of Focal as of and for the
                  three months ended March 31, 2001 and 2000. Filed herewith.


                                       2



                                    SIGNATURE

           Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                 GENZYME CORPORATION



Dated: May 22, 2001               By: /s/ Michael Wyzga
                                      -------------------------------
                                       Michael Wyzga
                                       Senior Vice President Finance,
                                       Chief Financial Officer
                                       and Chief Accounting Officer



                                       3


               UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION

    Genzyme and Focal, Inc. ("Focal") entered into a planned merger agreement on
April 25, 2001. The acquisition will be structured as a merger of a wholly-owned
subsidiary of Genzyme with and into Focal. On April 30, 2001 Genzyme also
entered into a stock purchase agreement with Wyntek Diagnostics, Inc. ("Wyntek")
and its stockholders pursuant to which Genzyme will acquire all or substantially
all of the outstanding capital stock of Wyntek. The Focal merger requires the
approval of Focal's shareholders, which has not yet been obtained.

    On December 14, 2000, Genzyme completed the acquisition of GelTex
Pharmaceuticals, Inc. ("GelTex"). The acquisition was structured as a merger of
GelTex with and into one of Genzyme's wholly-owned subsidiaries pursuant to an
Agreement and Plan of Merger, dated as of September 11, 2000.

    On December 18, 2000, Genzyme completed the acquisition of Biomatrix. The
acquisition was structured as a merger of Biomatrix with and into one of
Genzyme's wholly-owned subsidiaries pursuant to an Agreement and Plan of Merger,
dated as of March 6, 2000. Concurrent with the completion of Genzyme's
acquisition of Biomatrix, Genzyme amended its charter to create Genzyme
Biosurgery Division Common Stock ("Biosurgery Stock") and eliminate Genzyme
Surgical Products Division Common Stock ("Surgical Products Stock") and Genzyme
Tissue Repair Division Common Stock ("Tissue Repair Stock").

    The following unaudited pro forma combined financial information describes
the pro forma effect of Genzyme's acquisitions of Focal and Wyntek on the:

    - unaudited statements of operations for the three months ended March 31,
      2001 and the year ended December 31, 2000; and

    - unaudited balance sheet as of March 31, 2001

of both Genzyme and Genzyme Biosurgery, the division of Genzyme to which the
assets and liabilities and operations of Focal will be allocated.

    The following unaudited pro forma combined financial information also
describes the pro forma effect of Genzyme's merger with GelTex and Genzyme's
merger with Biomatrix on the unaudited statement of operations for the year
ended December 31, 2000 of both Genzyme and Genzyme Biosurgery, the division of
Genzyme to which the assets and liabilities and operations of Biomatrix were
allocated, as if these mergers took place on January 1, 2000. In addition, the
Genzyme pro forma statement of operations for the year ended December 31, 2000
reflects the change in earnings allocations resulting from the creation of
Biosurgery Stock and elimination of Surgical Products Stock and Tissue Repair
Stock as if this took place on January 1, 2000. The purpose of this pro forma
financial information is to demonstrate how the combined financial statements of
these businesses might have appeared if each of the mergers had been completed
at the beginning of the periods presented. The results of operations of GelTex
and Biomatrix are included in the results of Genzyme beginning on the respective
dates of acquisition.

    To determine earnings per share, Genzyme allocates its earnings to each
series of its common stock based on the earnings attributable to that series of
stock. The earnings attributable to each series of stock are defined in
Genzyme's charter as the net income or loss of the corresponding division
determined in accordance with generally accepted accounting principles and as
adjusted for tax benefits allocated to or from the division in accordance with
Genzyme's management and accounting policies. Genzyme's charter also requires
that all income and expenses of Genzyme be allocated among the divisions in a
reasonable and consistent manner. Genzyme's board of directors, however, retains
considerable discretion in determining the types, magnitudes and extent of
allocations to each series of common stock without shareholder approval.

                                       4

    Because the earnings allocated to Genzyme Biosurgery Stock are based on the
income or losses attributable to Genzyme Biosurgery, Genzyme included pro forma
financial statements of Genzyme Biosurgery to aid investors in evaluating its
performance.

    Holders of Genzyme Biosurgery Stock have no specific rights to the assets
allocated to Genzyme Biosurgery. Genzyme Corporation continues to hold title to
all of the assets allocated to Genzyme Biosurgery and is responsible for all of
its liabilities, regardless of what Genzyme deems for financial statement
presentation purposes as allocated to any division. Holders of Genzyme
Biosurgery Stock, as common stockholders, are therefore subject to the risks of
investing in the businesses, assets and liabilities of Genzyme, as a whole.

    Genzyme has prepared the pro forma financial information using the purchase
method of accounting for all four transactions. Genzyme expects to have
reorganization and restructuring expenses as well as potential operating
efficiencies as a result of the transactions with Focal and Wyntek. The
unaudited pro forma information does not reflect these potential expenses and
efficiencies.

    PENDING ACQUISITION OF FOCAL

    As a result of the merger with Focal, each outstanding share of Focal common
stock not already owned by Genzyme will automatically convert into the right to
receive 0.1545 of a share of Biosurgery Stock, except for 10,000 shares of Focal
common stock that will be purchased for cash. Genzyme will account for the
merger using the purchase method of accounting. Under the purchase method, the
assets and liabilities of Focal, including intangible assets, will be recorded
at their fair market values. The results of operations and cash flows of Focal
will be included in Genzyme's financial statements following the completion of
the merger. The assets, liabilities and operations of Focal will be allocated to
Genzyme Biosurgery.

    Additionally, each option and warrant to purchase shares of Focal common
stock outstanding immediately before the effective time of the merger will be
assumed by Genzyme after the merger and will become an option or warrant to
acquire Biosurgery Stock. The conversion of options to purchase Focal common
stock will be accounted for in accordance with Financial Accounting Standards
Board Interpretation No. 44 ("FIN 44").

    PENDING ACQUISITION OF WYNTEK

    Under the stock purchase agreement with Wyntek, Genzyme will purchase all of
the outstanding stock of Wyntek for approximately $65.0 million in cash. Genzyme
will account for the transaction using the purchase method of accounting. Under
this method, the assets and liabilities of Wyntek, including intangible assets,
will be recorded at their fair market values. The results of operations and cash
flows of Wyntek will be included in Genzyme's financial statements following the
completion of the transaction. No options or warrants will be assumed by Genzyme
in connection with the purchase. The assets, liabilities and operations of
Wyntek will be allocated to Genzyme General.

    ACQUISITION OF GELTEX

    Genzyme issued approximately 7.9 million shares of Genzyme General Stock and
paid cash of $515.2 million for all of the outstanding stock of GelTex. In
addition, Genzyme issued options and warrants to purchase Genzyme General Stock
in exchange for all outstanding GelTex options and warrants. The conversion of
options to purchase GelTex common stock was accounted for in accordance with FIN
44.

                                       5

    ACQUISITION OF BIOMATRIX

    Genzyme issued approximately 17.5 million shares of Biosurgery Stock and
paid cash of $252.4 million for all of the outstanding stock of Biomatrix. In
addition, Genzyme issued options to purchase Biosurgery Stock in exchange for
all outstanding Biomatrix options. The conversion of options to purchase
Biomatrix common stock was accounted for in accordance with FIN 44.

    TRACKING STOCK EXCHANGES

    In connection with the merger with Biomatrix, Genzyme effected an exchange
of its tracking stock whereby outstanding shares of Tissue Repair Stock and
Surgical Products Stock converted into Biosurgery Stock, the dividend and other
provisions of which are designed to track the financial performance of the
Genzyme Biosurgery division. Holders of Tissue Repair Stock and Surgical
Products Stock, therefore, remain holders of Genzyme common stock, but hold a
security whose dividend and other provisions are designed to track a different
subset of Genzyme's operations and assets. Additionally, the votes and
liquidation units per share of their holdings changed. Upon completion of the
tracking stock exchanges, each outstanding share of Surgical Products Stock
converted into the right to receive 0.6060 of a share of Biosurgery Stock and
each outstanding share of Tissue Repair Stock converted into the right to
receive 0.3352 of a share of Biosurgery Stock. Additionally, all outstanding
options to purchase Surgical Products Stock and Tissue Repair Stock converted
into options to purchase Biosurgery Stock at the respective conversion rates.

    The earnings attributable to Biosurgery Stock are defined in Genzyme's
charter as the net income or loss of Genzyme Biosurgery determined in accordance
with generally accepted accounting principles and as adjusted for tax benefits
allocated to or from Genzyme Biosurgery in accordance with Genzyme's management
and accounting policies. Prior to the tracking stock exchange, the earnings
attributable to Surgical Products Stock and Tissue Repair Stock were defined in
Genzyme's charter as the net income or loss of Genzyme Surgical Products and
Genzyme Tissue Repair, respectively, determined in accordance with generally
accepted accounting principles and as adjusted for tax benefits allocated to or
from the division. Accordingly, the tracking stock exchanges involved a change
in Genzyme's methodology for allocating its earnings to its series of common
stock.

    These unaudited pro forma balance sheets and statements of operations are
for informational purposes only. They do not purport to indicate the results
that would have actually been obtained had the mergers been completed on the
assumed date or for the periods presented, or which may be obtained in the
future. To produce the pro forma financial information, Genzyme allocated the
purchase price for the Focal and Wyntek mergers using its best estimates. The
unaudited pro forma balance sheets and statements of operations should be read
in conjunction with the historical consolidated financial statements, including
the notes thereto, of each of Genzyme, Focal, Wyntek, GelTex and Biomatrix. For
Genzyme, those financial statements are included in Genzyme's Quarterly Report
on Form 10-Q for the quarter ended March 31, 2001 (filed on May 15, 2001) and
its Annual Report on Form 10-K for the year ended December 31, 2000 (filed on
April 2, 2001). For GelTex those financial statements are included in GelTex's
Quarterly Report on Form 10-Q for the quarter ended September 30, 2000 (filed on
November 14, 2000) and its Annual Report on Form 10-K for the year ended
December 31, 1999 (filed on March 30, 2000), as amended on November 7, 2000. For
Biomatrix, those financial statements are included in Biomatrix's Quarterly
Report on Form 10-Q for the quarter ended September 30, 2000 (filed on
November 14, 2000) and its Annual Report on Form 10-K for the year ended
December 31, 1999 (filed on March 30, 2000), as amended on April 26, 2000 and
October 26, 2000. For Wyntek, those financials are included in Exhibit 99.1 to
Genzyme's Current Report on Form 8-K filed on May 18, 2001. For Focal, those
financial statements are included in Exhibit 99.1 and Exhibit 99.2 to this
Current Report on Form 8-K.

                                       6

                      GENZYME CORPORATION AND SUBSIDIARIES
              UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS
                      FOR THE YEAR ENDED DECEMBER 31, 2000
                             (AMOUNTS IN THOUSANDS)



                                        HISTORICAL
                                         GENZYME
                                       CORPORATION         HISTORICAL       PRO FORMA      NOTE      HISTORICAL    PRO FORMA
                                     AND SUBSIDIARIES   BIOMATRIX, INC.    ADJUSTMENTS   REFERENCE     GELTEX     ADJUSTMENTS
                                     ----------------   ----------------   -----------   ---------   ----------   -----------
                                                                                                
Revenues:
  Net product sales................     $ 811,897            $65,401        $     --                  $    --      $  6,166
  Net service sales................        84,482                 --              --        --             --            --
  Collaborative joint venture
    project reimbursement..........            --                 --              --        --          5,409        (5,409)
  Revenues from research and
    development contracts:
    Related parties................           509                 --              --                       --            --
    Other..........................         6,432                 --              --                   36,585            15
  Income from licenses, royalties,
    research contracts and
    grants.........................            --             10,221              --                       --            --
                                        ---------            -------        --------                  -------      --------
    Total revenues.................       903,320             75,622              --                   41,994           772
                                        ---------            -------        --------                  -------      --------
Operating costs and expenses:
  Cost of products sold............       232,383             20,395          11,330        B2             --         8,156
                                                                                                                      6,471
  Cost of services sold............        50,177                 --              --                       --            --
  Selling, general and
    administrative.................       264,551             33,576              21        B2
                                                                                (105)       B2         11,729         5,870
                                                                                                                      1,671
                                                                                                                      1,761
  Collaborative joint venture
    project costs..................            --                 --              --                    5,409        (5,409)
  Research and development
    (including research and
    development relating to
    contracts).....................       169,478             10,184              --                   33,727         7,042
                                                                                                                      4,568
  Amortization of intangibles......        22,974                 --          35,617        B1             --        59,876
  Purchase of in-process research
    and development................       200,191                 --         (82,143)       B8             --      (118,048)
  Charge for impaired asset........         4,321                 --              --                       --            --
                                        ---------            -------        --------                  -------      --------
    Total operating costs and
      expenses.....................       944,075             64,155         (35,280)                  50,865       (28,042)
                                        ---------            -------        --------                  -------      --------
Operating income (loss)............       (40,755)            11,467          35,280                   (8,871)       28,814
                                        ---------            -------        --------                  -------      --------
Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......       (44,965)                --              --                    1,582         8,277
                                                                                                                      1,812
                                                                                                                     (1,582)
  Gain on affiliate sale of
    stock..........................        22,689                 --              --                       --            --
  Gain on sale of investment in
    equity securities..............        23,173                 --              --                       --            --
  Minority interest................         4,625                 --              --                       --            --
  Charge for impaired
    investments....................        (7,300)                --              --                       --            --
  Other............................         5,188               (301)             --                       --            --
  Investment income................        45,593              3,402          (2,738)       B6          6,942       (18,923)
  Interest expense.................       (15,710)              (975)        (14,375)       B6           (697)          269
                                                                                                                    (10,781)
                                        ---------            -------        --------                  -------      --------
    Total other income
      (expenses)...................        33,293              2,126         (17,113)                   7,827       (20,928)
                                        ---------            -------        --------                  -------      --------
Income (loss) before income
  taxes............................        (7,462)            13,593          18,167                   (1,044)        7,886
(Provision for) benefit from income
  taxes............................       (55,478)            (6,513)         19,661        B5             --        27,824
                                        ---------            -------        --------                  -------      --------
Net income (loss)..................     $ (62,940)           $ 7,080        $ 37,828                  $(1,044)     $ 35,710
                                        =========            =======        ========                  =======      ========


                                                    PRO FORMA
                                                     GENZYME
                                                  CORPORATION,
                                       NOTE         BIOMATRIX
                                     REFERENCE     AND GELTEX
                                     ---------   ---------------
                                           
Revenues:
  Net product sales................  G6            $  883,464
  Net service sales................                    84,482
  Collaborative joint venture
    project reimbursement..........  G5                    --
  Revenues from research and
    development contracts:
    Related parties................                       509
    Other..........................  G6                43,032
  Income from licenses, royalties,
    research contracts and
    grants.........................                    10,221
                                                   ----------
    Total revenues.................                 1,021,708
                                                   ----------
Operating costs and expenses:
  Cost of products sold............  G2
                                      G6              278,735
  Cost of services sold............                    50,177
  Selling, general and
    administrative.................
                                      G6
                                      G2
                                      G2              319,074
  Collaborative joint venture
    project costs..................  G5
  Research and development
    (including research and
    development relating to
    contracts).....................  G2
                                      G6              224,999
  Amortization of intangibles......  G1,G6            118,467
  Purchase of in-process research
    and development................  G9                    --
  Charge for impaired asset........                     4,321
                                                   ----------
    Total operating costs and
      expenses.....................                   995,773
                                                   ----------
Operating income (loss)............                    25,935
                                                   ----------
Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......  G6
                                      G6
                                      G6              (34,876)
  Gain on affiliate sale of
    stock..........................  G5                22,689
  Gain on sale of investment in
    equity securities..............                    23,173
  Minority interest................                     4,625
  Charge for impaired
    investments....................                    (7,300)
  Other............................                     4,887
  Investment income................  G4                34,276
  Interest expense.................  G4
                                      G4              (42,269)
                                                   ----------
    Total other income
      (expenses)...................                     5,205
                                                   ----------
Income (loss) before income
  taxes............................                    31,140
(Provision for) benefit from income
  taxes............................  G7               (14,506)
                                                   ----------
Net income (loss)..................                $   16,634
                                                   ==========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       7

                      GENZYME CORPORATION AND SUBSIDIARIES
        UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS (CONTINUED)
                      FOR THE YEAR ENDED DECEMBER 31, 2000
                             (AMOUNTS IN THOUSANDS)


                                        PRO FORMA
                                         GENZYME
                                      CORPORATION,         HISTORICAL
                                        BIOMATRIX            WYNTEK          PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                       AND GELTEX      DIAGNOSTICS, INC.    ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                     ---------------   ------------------   -----------   ---------   -----------   -----------
                                                                                                  
Revenues:
  Net product sales................    $  883,464           $17,546           $    --                  $  1,721       $(1,454)
  Net service sales................        84,482                --                --                        --
  Collaborative research and
    development revenue............            --                --                --                       874          (874)
  Revenue from research and
    development contracts:                                       --                --                        --            --
    Related parties................           509                --                --                        --            --
    Other..........................        43,032                --                --                        --            --
  Income from licenses, royalties,
    research contracts and
    grants.........................        10,221                --                --                        --            --
                                       ----------           -------           -------                  --------       -------
    Total revenues.................     1,021,708            17,546                --                     2,595        (2,328)
                                       ----------           -------           -------                  --------       -------
Operating costs and expenses:
  Cost of products sold............       278,735             8,457               318         W7          2,842         5,078
                                                                                                                       (1,230)

  Cost of services sold............        50,177                --                --                        --            --
  Selling, general and
    administrative.................       319,074             1,557                --                     6,000           867
  Collaborative joint venture
    project costs..................            --                --                --                        --            --
  Research and development
    (including research and
    development relating to
    contracts).....................       224,999             1,686                --                     8,112            --
  Amortization of intangibles......       118,467                --             5,025         W6             --           318
  Purchase of in-process research
    and development................            --                --                --                        --            --
  Charge for impaired asset........         4,321                --                --                        --            --
                                       ----------           -------           -------                  --------       -------
    Total operating costs and
      expenses.....................       995,773            11,700             5,343                    16,954         5,033
                                       ----------           -------           -------                  --------       -------
Operating income (loss)............        25,935             5,846            (5,343)                  (14,359)       (7,361)
                                       ----------           -------           -------                  --------       -------
Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......       (34,876)               --                --                        --            --
  Gain on affiliate sale of
    stock..........................        22,689                --                --                        --            --
  Gain on sale of investment in
    equity securities..............        23,173                --                --                        --            --
  Minority interest................         4,625                --                --                        --            --
  Charge for impaired investment...        (7,300)               --                --                        --         7,300
  Other............................         4,887                --                --                       475            --
  Investment income................        34,276               258            (3,572)        W8            705            --
  Interest expense.................       (42,269)               --                --                      (298)           --
                                       ----------           -------           -------                  --------       -------
    Total other income
      (expenses)...................         5,205               258            (3,572)                      882         7,300
                                       ----------           -------           -------                  --------       -------
Income (loss) before income
  taxes............................        31,140             6,104            (8,915)                  (13,477)          (61)
(Provision for) benefit from income
  taxes............................       (14,506)           (2,208)            3,209         W9                        4,874
                                       ----------           -------           -------                  --------       -------
Income (loss) before cumulative
  effect of change in accounting
  principle........................        16,634             3,896            (5,706)                  (13,477)        4,813
Cumulative effect of a change in
  accounting principle, net of
  tax..............................            --                --                --                    (5,600)        5,600
                                       ----------           -------           -------                  --------       -------
Net income (loss)..................    $   16,634           $ 3,896           $(5,706)                 $(19,077)      $10,413
                                       ==========           =======           =======                  ========       =======


                                                  PRO FORMA
                                                   GENZYME
                                                 CORPORATION
                                       NOTE          AND
                                     REFERENCE   SUBSIDIARIES
                                     ---------   ------------
                                           
Revenues:
  Net product sales................  F10          $  901,277
  Net service sales................                   84,482
  Collaborative research and
    development revenue............  F11                  --
  Revenue from research and
    development contracts:                                --
    Related parties................                      509
    Other..........................                   43,032
  Income from licenses, royalties,
    research contracts and
    grants.........................                   10,221
                                                  ----------
    Total revenues.................                1,039,521
                                                  ----------
Operating costs and expenses:
  Cost of products sold............  F9
                                       F10           294,200
  Cost of services sold............                   50,177
  Selling, general and
    administrative.................  F9              327,498
  Collaborative joint venture
    project costs..................                       --
  Research and development
    (including research and
    development relating to
    contracts).....................                  234,797
  Amortization of intangibles......  F8              123,810
  Purchase of in-process research
    and development................                       --
  Charge for impaired asset........                    4,321
                                                  ----------
    Total operating costs and
      expenses.....................                1,034,803
                                                  ----------
Operating income (loss)............                    4,718
                                                  ----------
Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......                  (34,876)
  Gain on affiliate sale of
    stock..........................                   22,689
  Gain on sale of investment in
    equity securities..............                   23,173
  Minority interest................                    4,625
  Charge for impaired investment...  F10                  --
  Other............................                    5,362
  Investment income................                   31,667
  Interest expense.................                  (42,567)
                                                  ----------
    Total other income
      (expenses)...................                   10,073
                                                  ----------
Income (loss) before income
  taxes............................                   14,791
(Provision for) benefit from income
  taxes............................  F12              (8,631)
                                                  ----------
Income (loss) before cumulative
  effect of change in accounting
  principle........................                    6,160
Cumulative effect of a change in
  accounting principle, net of
  tax..............................  F11                  --
                                                  ----------
Net income (loss)..................               $    6,160
                                                  ==========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       8

                      GENZYME CORPORATION AND SUBSIDIARIES
        UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS (CONTINUED)
                      FOR THE YEAR ENDED DECEMBER 31, 2000
                 (AMOUNTS IN THOUSANDS, EXCEPT PER SHARE DATA)



                                        HISTORICAL
                                         GENZYME
                                       CORPORATION        HISTORICAL       PRO FORMA      NOTE      HISTORICAL    PRO FORMA
                                     AND SUBSIDIARIES   BIOMATRIX, INC.   ADJUSTMENTS   REFERENCE     GELTEX     ADJUSTMENTS
                                     ----------------   ---------------   -----------   ---------   ----------   -----------
                                                                                               
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income.......      $ 85,956                          $     --                               $  34,666
  Tax benefit allocated from
    Genzyme Molecular Oncology.....         7,476                                --                                      --
  Tax benefit allocated from
    Genzyme Biosurgery.............        28,023                              (352)          B7                         --
                                         --------                          --------                               ---------
  Net income allocated to Genzyme
    General Stock..................      $121,455                          $   (352)                              $  34,666
                                         ========                          ========                               =========
  Net income per share of Genzyme
    General Stock:
    Basic..........................      $   1.41
                                         ========
    Diluted........................      $   1.35
                                         ========
  Weighted average shares
    outstanding:
    Basic..........................        86,131                                                                     7,062
                                         ========                                                                 =========
    Diluted........................        89,683                                                                    14,463
                                         ========                                                                 =========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................      $(23,096)
                                         ========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................      $  (1.60)
                                         ========
  Weighted average shares
    outstanding....................        14,446
                                         ========
  ALLOCATED TO SURGICAL PRODUCTS
    STOCK:
  Net loss.........................      $(54,748)                         $ 54,748           B4
                                         ========                          ========
  Net loss per share of Surgical
    Products Stock--basic and
    diluted........................      $  (3.67)                         $   3.67           B4
                                         ========                          ========
  Weighted average shares
    outstanding....................        14,900                           (14,900)          B3
                                         ========                          ========
  ALLOCATED TO TISSUE REPAIR STOCK:
  Net loss.........................      $(19,833)                         $ 19,833           B4
                                         ========                          ========
  Net loss per share of Tissue
    Repair Stock--basic and
    diluted........................      $  (0.69)                         $   0.69           B4
                                         ========                          ========
  Weighted average shares
    outstanding....................        28,716                           (28,716)          B3
                                         ========                          ========
  BIOMATRIX, INC.:
  Net income.......................                         $ 7,080        $ (7,080)          B4
                                                            =======        ========
  Net income per Biomatrix common
    share-basic....................                         $  0.30        $  (0.30)          B4
                                                            =======        ========
  Weighted average shares
    outstanding....................                          23,401         (23,401)          B3
                                                            =======        ========
  Net income per Biomatrix common
    and common equivalent
    share-diluted..................                         $  0.29        $  (0.29)          B4
                                                            =======        ========
  Adjusted weighted average shares
    outstanding....................                          24,395         (24,395)          B3
                                                            =======        ========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......      $(87,636)                         $(42,821)          B4
  Allocated tax benefit............           448                            13,500           B9
                                         --------                          ========
  Net loss allocated to Biosurgery
    Stock..........................      $(87,188)                         $(29,321)          B4
                                         ========                          ========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......      $  (2.40)
                                         ========
  Weighted average shares
    outstanding....................        36,359                              (686)          B3
                                         ========                          ========
  GELTEX PHARMACEUTICALS, INC.:
  Net loss.........................                                                                  $(1,044)     $   1,044
                                                                                                     =======      =========
  Net loss per share of GelTex
    common stock--basic and
    diluted........................                                                                  $ (0.05)     $    0.05
                                                                                                     =======      =========
  Weighted average shares
    outstanding....................                                                                   19,872        (19,872)
                                                                                                     =======      =========


                                                  PRO FORMA
                                                   GENZYME
                                                 CORPORATION,
                                       NOTE       BIOMATRIX
                                     REFERENCE    AND GELTEX
                                     ---------   ------------
                                           
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income.......     G8        $ 120,622
  Tax benefit allocated from
    Genzyme Molecular Oncology.....                   7,476
  Tax benefit allocated from
    Genzyme Biosurgery.............                  27,671
                                                  ---------
  Net income allocated to Genzyme
    General Stock..................               $ 155,769
                                                  =========
  Net income per share of Genzyme
    General Stock:
    Basic..........................               $    1.67
                                                  =========
    Diluted........................               $    1.59
                                                  =========
  Weighted average shares
    outstanding:
    Basic..........................     G3           93,193
                                                  =========
    Diluted........................     G3          104,146
                                                  =========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................               $ (23,096)
                                                  =========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................               $   (1.60)
                                                  =========
  Weighted average shares
    outstanding....................                  14,446
                                                  =========
  ALLOCATED TO SURGICAL PRODUCTS
    STOCK:
  Net loss.........................               $      --
                                                  =========
  Net loss per share of Surgical
    Products Stock--basic and
    diluted........................               $      --
                                                  =========
  Weighted average shares
    outstanding....................                      --
                                                  =========
  ALLOCATED TO TISSUE REPAIR STOCK:
  Net loss.........................               $      --
                                                  =========
  Net loss per share of Tissue
    Repair Stock--basic and
    diluted........................               $      --
                                                  =========
  Weighted average shares
    outstanding....................                      --
                                                  =========
  BIOMATRIX, INC.:
  Net income.......................               $      --
                                                  =========
  Net income per Biomatrix common
    share-basic....................               $      --
                                                  =========
  Weighted average shares
    outstanding....................                      --
                                                  =========
  Net income per Biomatrix common
    and common equivalent
    share-diluted..................               $      --
                                                  =========
  Adjusted weighted average shares
    outstanding....................                      --
                                                  =========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......               $(130,457)
  Allocated tax benefit............                  13,948
                                                  =========
  Net loss allocated to Biosurgery
    Stock..........................               $(116,509)
                                                  =========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......               $   (3.27)
                                                  =========
  Weighted average shares
    outstanding....................                  35,673
                                                  =========
  GELTEX PHARMACEUTICALS, INC.:
  Net loss.........................     G8        $      --
                                                  =========
  Net loss per share of GelTex
    common stock--basic and
    diluted........................     G8        $      --
                                                  =========
  Weighted average shares
    outstanding....................     G3               --
                                                  =========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       9

                      GENZYME CORPORATION AND SUBSIDIARIES
        UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS (CONTINUED)
                      FOR THE YEAR ENDED DECEMBER 31, 2000
                 (AMOUNTS IN THOUSANDS, EXCEPT PER SHARE DATA)


                                      PRO FORMA
                                       GENZYME
                                     CORPORATION,      HISTORICAL
                                      BIOMATRIX          WYNTEK          PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                      AND GELTEX    DIAGNOSTICS, INC.   ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                     ------------   -----------------   -----------   ---------   -----------   -----------
                                                                                              
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income.......   $ 120,622                          $ (1,810)         W10                   $     --
  Tax benefit allocated from
    Genzyme Molecular Oncology.....       7,476                                --                                      --
  Tax benefit allocated from
    Genzyme Biosurgery.............      27,671                                --                                   4,874
                                      ---------                          --------                                --------
  Net income allocated to Genzyme
    General Stock..................   $ 155,769                          $ (1,810)                               $  4,874
                                      =========                          ========                                ========
  Net income per share of Genzyme
    General Stock:
    Basic..........................   $    1.67
                                      =========
    Diluted........................   $    1.59
                                      =========
  Weighted average shares
    outstanding:
    Basic..........................      93,193
                                      =========
    Diluted........................     104,146
                                      =========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................   $ (23,096)
                                      =========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................   $   (1.60)
                                      =========
  Weighted average shares
    outstanding....................      14,446
                                      =========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......   $(130,457)                                                                 $(13,538)
  Allocated tax benefit............      13,948                                                                        --
                                      ---------                                                                  --------
  Net loss allocated to Biosurgery
    Stock..........................   $(116,509)                                                                 $(13,538)
                                      =========                                                                  ========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......   $   (3.27)
                                      =========
  Weighted average shares
    outstanding....................      35,673                                                                     2,086
                                      =========                                                                  ========
WYNTEK DIAGNOSTICS, INC.
  Net income.......................                      $ 3,896         $ (3,896)         W10
                                                         =======         ========
  Net income per share of Wyntek
    common stock--basic............                      $  0.95         $  (0.95)         W10
                                                         =======         ========
  Weighted average shares
    outstanding....................                        4,120           (4,120)         W10
                                                         =======         ========
  Net income per share of Wyntek
    common stock--diluted..........                      $  0.87         $  (0.87)         W10
                                                         =======         ========
  Adjusted weighted average shares
    outstanding....................                        4,488           (4,488)         W10
                                                         =======         ========
FOCAL, INC.
  Net loss.........................                                                                $(19,077)     $ 19,077
                                                                                                   ========      ========
  Net loss per Focal common
    share--basic and diluted.......                                                                $  (1.30)     $   1.30
                                                                                                   ========      ========
  Weighted average shares
    outstanding....................                                                                  14,707       (14,707)
                                                                                                   ========      ========



                                                     PRO FORMA
                                                      GENZYME
                                        NOTE        CORPORATION
                                     REFERENCE    AND SUBSIDIARIES
                                     ----------   ----------------
                                            
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income.......                  $ 118,812
  Tax benefit allocated from
    Genzyme Molecular Oncology.....                      7,476
  Tax benefit allocated from
    Genzyme Biosurgery.............     F14             32,545
                                                     ---------
  Net income allocated to Genzyme
    General Stock..................                  $ 158,833
                                                     =========
  Net income per share of Genzyme
    General Stock:
    Basic..........................                  $    1.70
                                                     =========
    Diluted........................                  $    1.62
                                                     =========
  Weighted average shares
    outstanding:
    Basic..........................                     93,193
                                                     =========
    Diluted........................                    104,146
                                                     =========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................                  $ (23,096)
                                                     =========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................                  $   (1.60)
                                                     =========
  Weighted average shares
    outstanding....................                     14,446
                                                     =========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......     F13          $(143,995)
  Allocated tax benefit............                     13,948
                                                     ---------
  Net loss allocated to Biosurgery
    Stock..........................                  $(130,047)
                                                     =========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......                  $   (3.44)
                                                     =========
  Weighted average shares
    outstanding....................     F13             37,759
                                                     =========
WYNTEK DIAGNOSTICS, INC.
  Net income.......................

  Net income per share of Wyntek
    common stock--basic............

  Weighted average shares
    outstanding....................

  Net income per share of Wyntek
    common stock--diluted..........

  Adjusted weighted average shares
    outstanding....................

FOCAL, INC.
  Net loss.........................     F13          $      --
                                                     =========
  Net loss per Focal common
    share--basic and diluted.......     F13          $      --
                                                     =========
  Weighted average shares
    outstanding....................     F13                 --
                                                     =========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       10

                      GENZYME CORPORATION AND SUBSIDIARIES
              UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS
                   FOR THE THREE MONTHS ENDED MARCH 31, 2001
                 (AMOUNTS IN THOUSANDS, EXCEPT PER SHARE DATA)



                                        HISTORICAL
                                         GENZYME           HISTORICAL
                                       CORPORATION           WYNTEK          PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                     AND SUBSIDIARIES   DIAGNOSTICS, INC.   ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                     ----------------   -----------------   -----------   ---------   -----------   -----------
                                                                                                  
Revenues:
  Net product sales................      $250,830             $5,855         $     --                 $       613    $    (571)
  Net service sales................        23,760                 --                                           --
  Collaborative research and
    development revenue............                                                                           249         (249)
  Revenue from research and
    development contracts:
    Related parties................           319                 --               --                          --           --
    Other..........................         3,352                 --               --                          --           --
                                         --------             ------         --------                 -----------    ---------
      Total revenues...............       278,261              5,855               --                         862         (820)
                                         --------             ------         --------                 -----------    ---------

Operating costs and expenses:
  Cost of products sold............        76,532              2,208               --                         771         (429)
  Cost of services sold............        13,421                 --               --                          --           --
  Selling, general and
    administrative.................        91,114                864               --                       1,446          217
  Research and development
    (including research and
    development related to
    contracts).....................        57,110                490               --                       1,369           --
  Amortization of intangibles......        28,991                 --            1,256         W6               --           80
                                         --------             ------         --------                 -----------    ---------
      Total operating costs and
        expenses...................       267,168              3,562            1,256                       3,586         (132)
                                         --------             ------         --------                 -----------    ---------

Operating income (loss)............        11,093              2,293           (1,256)                     (2,724)        (688)
                                         --------             ------         --------                 -----------    ---------

Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......        (9,015)                --               --                          --          536
  Minority interest................         1,274                 --               --                          --           --
  Other............................        (3,710)                --               --                          --           --
  Investment income................        10,148                 66             (893)        W8               99           --
  Interest expense.................       (11,370)                --               --                          --           --
                                         --------             ------         --------                 -----------    ---------
      Total other income
        (expenses).................       (12,673)                66             (893)                         99          536
                                         --------             ------         --------                 -----------    ---------

Income (loss) before income
  taxes............................        (1,580)             2,359           (2,149)                     (2,625)        (152)
(Provision for) benefit from income
  taxes............................           670               (850)             774         W9               --        1,000
                                         --------             ------         --------                 -----------    ---------
Income (loss) before cumulative
  effect of change in accounting
  principle........................          (910)             1,509           (1,375)                     (2,625)         848
Cumulative effect of change in
  accounting principle, net of
  tax..............................         4,167                 --               --                          --           --
                                         --------             ------         --------                 -----------    ---------
Net income (loss)..................      $  3,257             $1,509         $ (1,375)                $    (2,625)   $     848
                                         ========             ======         ========                 ===========    =========


                                                    PRO FORMA
                                                     GENZYME
                                                   CORPORATION
                                       NOTE            AND
                                     REFERENCE    SUBSIDIARIES
                                     ---------   ---------------
                                           
Revenues:
  Net product sales................       F10      $   256,727
  Net service sales................                     23,760
  Collaborative research and
    development revenue............       F11
  Revenue from research and
    development contracts:
    Related parties................                        319
    Other..........................                      3,352
                                                   -----------
      Total revenues...............                    284,158
                                                   -----------
Operating costs and expenses:
  Cost of products sold............       F10           79,082
  Cost of services sold............                     13,421
  Selling, general and
    administrative.................        F9           93,641
  Research and development
    (including research and
    development related to
    contracts).....................                     58,969
  Amortization of intangibles......        F8           30,327
                                                   -----------
      Total operating costs and
        expenses...................                    275,440
                                                   -----------
Operating income (loss)............                      8,718
                                                   -----------
Other income (expenses):
  Equity in net loss of
    unconsolidated affiliates......                     (8,479)
  Minority interest................                      1,274
  Other............................                     (3,710)
  Investment income................                      9,420
  Interest expense.................                    (11,370)
                                                   -----------
      Total other income
        (expenses).................                    (12,865)
                                                   -----------
Income (loss) before income
  taxes............................                     (4,147)
(Provision for) benefit from income
  taxes............................       F12            1,594
                                                   -----------
Income (loss) before cumulative
  effect of change in accounting
  principle........................                     (2,553)
Cumulative effect of change in
  accounting principle, net of
  tax..............................                      4,167
                                                   -----------
Net income (loss)..................                $     1,614
                                                   ===========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       11

                      GENZYME CORPORATION AND SUBSIDIARIES
        UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS (CONTINUED)
                   FOR THE THREE MONTHS ENDED MARCH 31, 2001
                 (AMOUNTS IN THOUSANDS, EXCEPT PER SHARE DATA)


                                        HISTORICAL       HISTORICAL
                                         GENZYME           WYNTEK
                                       CORPORATION      DIAGNOSTICS,    PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                     AND SUBSIDIARIES       INC.       ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                     ----------------   ------------   -----------   ---------   -----------   -----------
                                                                                             
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income before
    cumulative effect of change in
    accounting principle...........      $ 25,145                       $    134        W10                     $     --
  Cumulative effect of change in
    accounting principle, net of
    tax............................         4,167                             --                                      --
                                         --------                       --------                                --------
  Genzyme General net income.......        29,312                            134                                      --
  Tax benefit allocated from
    Genzyme Biosurgery.............         8,116                             --                                   1,000
  Tax benefit allocated from
    Genzyme Molecular Oncology.....         2,826                             --                                      --
                                         --------                       --------                                --------
  Net income allocated to Genzyme
    General Stock..................      $ 40,254                       $    134                                $  1,000
                                         ========                       ========                                ========
  Net income per share of Genzyme
    General Stock:
  Basic:
  Net income per share before
    cumulative effect of change in
    accounting principle...........      $   0.38
  Per share cumulative effect of
    change in accounting principle,
    net of tax.....................          0.04
                                         --------
  Net income per share allocated to
    Genzyme General Stock..........      $   0.42
                                         ========
  Diluted:
  Net income per share before
    cumulative effect of change in
    accounting principle...........      $   0.36
  Per share cumulative effect of
    change in accounting principle,
    net of tax.....................          0.04
                                         --------
  Net income per share allocated to
    Genzyme General Stock..........      $   0.40
                                         ========
  Weighted average shares
    outstanding:
  Basic............................        95,875
                                         ========
  Diluted..........................       100,400
                                         ========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................      $ (6,274)
                                         ========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................      $  (0.39)
                                         ========
  Weighted average shares
    outstanding....................        15,907
                                         ========
  FOCAL, INC.:
  Net loss.........................                                                                $(2,625)     $  2,625
                                                                                                   =======      ========
  Net loss per share of Focal
    common stock--basic and
    diluted........................                                                                $ (0.15)     $   0.15
                                                                                                   =======      ========
  Weighted average shares
    outstanding....................                                                                 17,283       (17,283)
                                                                                                   =======      ========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......      $(35,327)                                                              $ (2,777)
  Allocated tax benefit............         4,604                                                                     --
                                         --------                                                               --------
  Net loss allocated to Biosurgery
    Stock..........................      $(30,723)                                                              $ (2,777)
                                         ========                                                               ========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......      $  (0.84)
                                         ========
  Weighted average shares
    outstanding....................        36,402                                                                  2,086
                                         ========                                                               ========
  WYNTEK DIAGNOSTICS, INC.:
  Net income.......................                       $ 1,509       $ (1,509)       W10
                                                          =======       ========
  Net income per share of Wyntek
    common stock--basic............                       $  0.37       $  (0.37)       W10
                                                          =======       ========
  Weighted average shares
    outstanding....................                         4,125         (4,125)       W10
                                                          =======       ========
  Net income per share of Wyntek
    common stock and equivalent
    share--diluted.................                       $  0.34       $  (0.34)       W10
                                                          =======       ========
  Adjusted weighted average shares
    outstanding....................                         4,487         (4,487)       W10
                                                          =======       ========


                                                    PRO FORMA
                                                     GENZYME
                                       NOTE        CORPORATION
                                     REFERENCE   AND SUBSIDIARIES
                                     ---------   ----------------
                                           
NET INCOME (LOSS) PER SHARE:
  ALLOCATED TO GENZYME GENERAL
    STOCK:
  Genzyme General net income before
    cumulative effect of change in
    accounting principle...........                  $ 25,279
  Cumulative effect of change in
    accounting principle, net of
    tax............................                     4,167
                                                     --------
  Genzyme General net income.......                    29,446
  Tax benefit allocated from
    Genzyme Biosurgery.............     F14             9,116
  Tax benefit allocated from
    Genzyme Molecular Oncology.....                     2,826
                                                     --------
  Net income allocated to Genzyme
    General Stock..................                  $ 41,388
                                                     ========
  Net income per share of Genzyme
    General Stock:
  Basic:
  Net income per share before
    cumulative effect of change in
    accounting principle...........                  $   0.39
  Per share cumulative effect of
    change in accounting principle,
    net of tax.....................                      0.04
                                                     --------
  Net income per share allocated to
    Genzyme General Stock..........                  $   0.43
                                                     ========
  Diluted:
  Net income per share before
    cumulative effect of change in
    accounting principle...........                  $   0.37
  Per share cumulative effect of
    change in accounting principle,
    net of tax.....................                      0.04
                                                     --------
  Net income per share allocated to
    Genzyme General Stock..........                  $   0.41
                                                     ========
  Weighted average shares
    outstanding:
  Basic............................                    95,875
                                                     ========
  Diluted..........................                   100,400
                                                     ========
  ALLOCATED TO MOLECULAR ONCOLOGY
    STOCK:
  Net loss.........................                  $ (6,274)
                                                     ========
  Net loss per share of Molecular
    Oncology Stock--basic and
    diluted........................                  $  (0.39)
                                                     ========
  Weighted average shares
    outstanding....................                    15,907
                                                     ========
  FOCAL, INC.:
  Net loss.........................     F13          $     --
                                                     ========
  Net loss per share of Focal
    common stock--basic and
    diluted........................     F13          $     --
                                                     ========
  Weighted average shares
    outstanding....................     F13                --
                                                     ========
  ALLOCATED TO BIOSURGERY STOCK:
  Genzyme Biosurgery net loss......     F13          $(38,104)
  Allocated tax benefit............                     4,604
                                                     --------
  Net loss allocated to Biosurgery
    Stock..........................                  $(33,500)
                                                     ========
  Net loss per share of Biosurgery
    Stock--basic and diluted.......                  $  (0.87)
                                                     ========
  Weighted average shares
    outstanding....................     F13            38,488
                                                     ========
  WYNTEK DIAGNOSTICS, INC.:
  Net income.......................                  $     --
                                                     ========
  Net income per share of Wyntek
    common stock--basic............                  $     --
                                                     ========
  Weighted average shares
    outstanding....................                        --
                                                     ========
  Net income per share of Wyntek
    common stock and equivalent
    share--diluted.................                  $     --
                                                     ========
  Adjusted weighted average shares
    outstanding....................                        --
                                                     ========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       12

                      GENZYME CORPORATION AND SUBSIDIARIES

                   UNAUDITED PRO FORMA COMBINED BALANCE SHEET

                              AS OF MARCH 31, 2001
                             (AMOUNTS IN THOUSANDS)


                                          HISTORICAL
                                            GENZYME          HISTORICAL
                                        CORPORATION AND        WYNTEK          PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                         SUBSIDIARIES     DIAGNOSTICS, INC.   ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                        ---------------   -----------------   -----------   ---------   -----------   -----------
                                                                                                    
ASSETS
Current assets:
  Cash and cash equivalents...........    $  207,582          $  4,779         $ (65,650)       W1       $  5,490      $    (507)
  Short-term investments..............       122,557                --                --                      201
  Accounts receivable, net............       211,452             3,826                --                      432           (370)
  Inventories.........................       165,437             2,091               318        W3          1,511          5,078
  Prepaid expenses and other current
    assets............................        36,537               100                --                      406             --
  Deferred tax assets--current........        45,024               229              (229)       W4             --             --
                                          ----------          --------         ---------                 --------      ---------
      Total current assets............       788,589            11,025           (65,561)                   8,040          4,201
Property, plant and equipment, net....       512,386             1,970                --                    2,020             --
Long-term investments.................       289,475                --                --                       --             --
Notes receivable--related party.......        10,159                --                --                      174            (37)
Intangibles, net......................     1,536,065                --            49,122        W1             --          3,817
Investments in equity securities......        76,903                --                --                       --             --
Other noncurrent assets...............        50,835                40                --                       --          2,600
                                                                                                                          (6,165)
                                          ----------          --------         ---------                 --------      ---------
      Total assets....................    $3,264,412          $ 13,035         $ (16,439)                $ 10,234      $   4,416
                                          ==========          ========         =========                 ========      =========


                                                       PRO FORMA
                                                        GENZYME
                                          NOTE      CORPORATION AND
                                        REFERENCE    SUBSIDIARIES
                                        ---------   ---------------
                                              
ASSETS
Current assets:
  Cash and cash equivalents...........      F1        $  151,694
  Short-term investments..............                   122,758
  Accounts receivable, net............      F5           215,340
  Inventories.........................      F4           174,435
  Prepaid expenses and other current
    assets............................                    37,043
  Deferred tax assets--current........                    45,024
                                                      ----------
      Total current assets............                   746,294
Property, plant and equipment, net....                   516,376
Long-term investments.................                   289,475
Notes receivable--related party.......      F3            10,296
Intangibles, net......................      F1         1,589,004
Investments in equity securities......                    76,903
Other noncurrent assets...............      F6
                                            F5            47,310
                                                      ----------
      Total assets....................                $3,275,658
                                                      ==========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       13

                      GENZYME CORPORATION AND SUBSIDIARIES
             UNAUDITED PRO FORMA COMBINED BALANCE SHEET (CONTINUED)
                              AS OF MARCH 31, 2001
                             (AMOUNTS IN THOUSANDS)



                                     HISTORICAL       HISTORICAL
                                       GENZYME          WYNTEK          PRO FORMA      NOTE      HISTORICAL     PRO FORMA
                                     CORPORATION   DIAGNOSTICS, INC.   ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS
                                     -----------   -----------------   -----------   ---------   -----------   -----------
                                                                                             
LIABILITIES AND STOCKHOLDERS'
  EQUITY
Current liabilities:
  Accounts payable.................  $   30,133        $  1,021         $      --                  $   278      $      --
  Accrued expenses.................     110,960           1,836             1,000        W2          1,909          1,125
                                                                                                                      700
Income taxes payable...............      48,956             605                --                       --             --
Deferred revenue...................       5,401              --                --                      883           (883)
Current portion of notes payable
  and long-term debt and capital
  lease obligations................      19,869              --                --                      600             --
                                     ----------        --------         ---------                  -------      ---------
      Total current liabilities....     215,319           3,462             1,000                    3,670            942
Notes payable and long-term debt
  and capital lease obligations....     381,089              --                --                      535             --
Convertible notes and debentures,
  net..............................     283,485              --                --                       --             --
Deferred Revenue--noncurrent.......          --              --                --                    3,800         (3,800)
Deferred tax
  liabilities--noncurrent..........     206,980              --                --                       --             --
Other noncurrent liabilities.......       9,182              --                --                       --             --
                                     ----------        --------         ---------                  -------      ---------
      Total liabilities............   1,096,055           3,462             1,000                    8,005         (2,858)
                                     ----------        --------         ---------                  -------      ---------
Stockholders' equity:
  Genzyme General Stock, $.01 par
    value..........................         963              --                --                       --             --
  Molecular Oncology Stock, $.01
    par value......................         160              --                --                       --             --
  Biosurgery Stock, $.01 par
    value..........................         365              --                --                       --             21
  Treasury Stock--at cost..........        (901)             --                --                       --             --
  Additional paid-in
    capital--Genzyme General
    Stock..........................   1,290,189              --                --                       --             --
  Additional paid-in
    capital--Molecular Oncology
    Stock..........................     111,665              --                --                       --             --
  Additional paid-in
    capital--Biosurgery Stock......     823,631              --                --                       --          9,513
                                                                                                                      389
  Notes receivable--related
    parties........................     (11,529)             --                --                       --           (420)
Deferred compensation..............      (7,319)             --                --                       --             --
Accumulated deficit................      (2,481)             --            (7,866)       W1             --             --
Wyntek Diagnostics, Inc. preferred
  stock, none issued...............          --              --                --                       --             --
Wyntek Diagnostics, Inc. common
  stock............................          --           3,357            (3,357)       W5             --             --
Wyntek Diagnostics, Inc. additional
  paid-in capital..................          --              --                --                       --             --
Wyntek Diagnostics, Inc. notes
  receivable--related parties......          --              --                --                       --             --
Wyntek Diagnostics, Inc. retained
  earnings.........................          --           6,216            (6,216)       W5             --             --
Wyntek Diagnostics, Inc. treasury
  stock, at cost...................          --              --                --                       --             --
Focal, Inc. preferred stock, none
  issued...........................          --              --                --                       --             --
Focal, Inc. common stock, $.0001
  par value........................          --              --                --                      174           (174)
Focal, Inc. additional paid-in
  capital..........................          --              --                --                  100,344       (100,344)
Focal, Inc. notes
  receivable--related parties......          --              --                --                     (420)           420
Focal, Inc. accumulated deficit....          --              --                --                  (97,870)        97,870
Focal, Inc. treasury stock, at
  cost.............................          --              --                --                       --             --
Accumulated other comprehensive
  income (loss)....................     (36,386)             --                --                        1             (1)
                                     ----------        --------         ---------                  -------      ---------
    Total stockholders' equity.....   2,168,357           9,573           (17,439)                   2,229          7,274
                                     ----------        --------         ---------                  -------      ---------
    Total liabilities and
     stockholders' equity..........  $3,264,412        $ 13,035         $ (16,439)                 $10,234      $   4,416
                                     ==========        ========         =========                  =======      =========


                                                  PRO FORMA
                                                   GENZYME
                                                 CORPORATION
                                       NOTE          AND
                                     REFERENCE   SUBSIDIARIES
                                     ---------   ------------
                                           
LIABILITIES AND STOCKHOLDERS'
  EQUITY
Current liabilities:
  Accounts payable.................              $    31,432
  Accrued expenses.................      F2
                                         F2          117,530
Income taxes payable...............                   49,561
Deferred revenue...................      F7            5,401
Current portion of notes payable
  and long-term debt and capital
  lease obligations................                   20,469
                                                 -----------
      Total current liabilities....                  224,393
Notes payable and long-term debt
  and capital lease obligations....                  381,624
Convertible notes and debentures,
  net..............................                  283,485
Deferred Revenue--noncurrent.......      F7               --
Deferred tax
  liabilities--noncurrent..........                  206,980
Other noncurrent liabilities.......                    9,182
                                                 -----------
      Total liabilities............                1,105,664
                                                 -----------
Stockholders' equity:
  Genzyme General Stock, $.01 par
    value..........................                      963
  Molecular Oncology Stock, $.01
    par value......................                      160
  Biosurgery Stock, $.01 par
    value..........................      F1              386
  Treasury Stock--at cost..........                     (901)
  Additional paid-in
    capital--Genzyme General
    Stock..........................                1,290,189
  Additional paid-in
    capital--Molecular Oncology
    Stock..........................                  111,665
  Additional paid-in
    capital--Biosurgery Stock......      F1
                                         F1          833,533
  Notes receivable--related
    parties........................      F3          (11,949)
Deferred compensation..............                   (7,319)
Accumulated deficit................                  (10,347)
Wyntek Diagnostics, Inc. preferred
  stock, none issued...............                       --
Wyntek Diagnostics, Inc. common
  stock............................                       --
Wyntek Diagnostics, Inc. additional
  paid-in capital..................                       --
Wyntek Diagnostics, Inc. notes
  receivable--related parties......                       --
Wyntek Diagnostics, Inc. retained
  earnings.........................                       --
Wyntek Diagnostics, Inc. treasury
  stock, at cost...................                       --
Focal, Inc. preferred stock, none
  issued...........................                       --
Focal, Inc. common stock, $.0001
  par value........................      F3               --
Focal, Inc. additional paid-in
  capital..........................      F3               --
Focal, Inc. notes
  receivable--related parties......      F3               --
Focal, Inc. accumulated deficit....      F3               --
Focal, Inc. treasury stock, at
  cost.............................                       --
Accumulated other comprehensive
  income (loss)....................      F3          (36,386)
                                                 -----------
    Total stockholders' equity.....                2,169,994
                                                 -----------
    Total liabilities and
     stockholders' equity..........              $ 3,275,658
                                                 ===========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       14

                               GENZYME BIOSURGERY
                       A DIVISION OF GENZYME CORPORATION
             UNAUDITED PRO FORMA COMBINED STATEMENTS OF OPERATIONS
                      FOR THE YEAR ENDED DECEMBER 31, 2000
                             (AMOUNTS IN THOUSANDS)


                                     HISTORICAL
                                      GENZYME       HISTORICAL       PRO FORMA      NOTE      HISTORICAL     PRO FORMA      NOTE
                                     BIOSURGERY   BIOMATRIX, INC.   ADJUSTMENTS   REFERENCE   FOCAL, INC.   ADJUSTMENTS   REFERENCE
                                     ----------   ---------------   -----------   ---------   -----------   -----------   ---------
                                                                                                     
Revenues:
  Net product sales................  $ 121,870        $65,401        $     --                  $  1,721      $ (1,454)       F24
  Net service sales................     23,321             --              --                        --            --
  Collaborative research and
    development revenue............         --             --                                       874          (874)       F25
  Revenue from research and
    development contracts..........         23             --              --                        --            --
  Income from licenses, royalties,
    research contracts.............         --         10,221              --                        --            --
                                     ---------        -------        --------                  --------      --------
    Total revenues.................    145,214         75,622              --                     2,595        (2,328)
                                     ---------        -------        --------                  --------      --------

Operating costs and expenses:
  Cost of products sold............     69,489         20,395          11,330        B11          2,842         5,078        F23
                                                                                                               (1,230)       F24
  Cost of services sold............     12,298             --              --                        --            --
  Selling, general and
    administrative.................     92,238         33,576              21        B11
                                                                         (105)       B11          6,000           867        F23
  Research and development
    (including research and
    development relating to
    contracts).....................     37,000         10,184              --                     8,112            --
  Amortization of intangibles......      7,096             --          35,617        B10             --           318        F22
  Purchase of in-process research
    and development................     82,143             --         (82,143)       B14             --            --
  Charge for impaired asset........      4,321             --                                        --            --
                                     ---------        -------        --------                  --------      --------
    Total operating costs and
      expenses.....................    304,585         64,155         (35,280)                   16,954         5,033
                                     ---------        -------        --------                  --------      --------
Operating income (loss)............   (159,371)        11,467          35,280                   (14,359)       (7,361)
                                     ---------        -------        --------                  --------      --------

Other income (expenses):
  Charge for impaired investment...     (7,300)            --              --                        --         7,300        F24
  Other............................        (15)          (301)             --                       475            --
  Investment income................      5,833          3,402          (2,738)       B13            705            --
  Interest expense.................     (1,364)          (975)        (14,375)       B13           (298)           --
                                     ---------        -------        --------                  --------      --------
    Total other income
      (expenses)...................     (2,846)         2,126         (17,113)                      882         7,300
                                     ---------        -------        --------                  --------      --------
Income (loss) before income
  taxes............................   (162,217)        13,593          18,167                   (13,477)          (61)
Provision for income taxes.........                    (6,513)          6,513        B12             --            --
                                     ---------        -------        --------                  --------      --------
Loss before cumulative effect of
  change in accounting principle...   (162,217)         7,080          24,680                   (13,477)          (61)
Cumulative effect of change in
  accounting principle, net of
  tax..............................         --             --              --                    (5,600)        5,600        F25
                                     ---------        -------        --------                  --------      --------
Division net loss..................  $(162,217)       $ 7,080        $ 24,680                  $(19,077)     $  5,539
                                     =========        =======        ========                  ========      ========


                                      PRO FORMA
                                       GENZYME
                                     BIOSURGERY
                                     -----------
                                  
Revenues:
  Net product sales................   $ 187,538
  Net service sales................      23,321
  Collaborative research and
    development revenue............          --
  Revenue from research and
    development contracts..........          23
  Income from licenses, royalties,
    research contracts.............      10,221
                                      ---------
    Total revenues.................     221,103
                                      ---------
Operating costs and expenses:
  Cost of products sold............
                                        107,904
  Cost of services sold............      12,298
  Selling, general and
    administrative.................
                                        132,597
  Research and development
    (including research and
    development relating to
    contracts).....................      55,296
  Amortization of intangibles......      43,031
  Purchase of in-process research
    and development................          --
  Charge for impaired asset........       4,321
                                      ---------
    Total operating costs and
      expenses.....................     355,447
                                      ---------
Operating income (loss)............    (134,344)
                                      ---------
Other income (expenses):
  Charge for impaired investment...          --
  Other............................         159
  Investment income................       7,202
  Interest expense.................     (17,012)
                                      ---------
    Total other income
      (expenses)...................      (9,651)
                                      ---------
Income (loss) before income
  taxes............................    (143,995)
Provision for income taxes.........          --
                                      ---------
Loss before cumulative effect of
  change in accounting principle...    (143,995)
Cumulative effect of change in
  accounting principle, net of
  tax..............................          --
                                      ---------
Division net loss..................   $(143,995)
                                      =========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS.

                                       15

                               GENZYME BIOSURGERY

                       A DIVISION OF GENZYME CORPORATION

             UNAUDITED PRO FORMA COMBINED STATEMENTS OF OPERATIONS

                   FOR THE THREE MONTHS ENDED MARCH 31, 2001
                             (AMOUNTS IN THOUSANDS)



                                                  HISTORICAL                                           PRO FORMA
                                                   GENZYME     HISTORICAL     PRO FORMA      NOTE       GENZYME
                                                  BIOSURGERY   FOCAL, INC.   ADJUSTMENTS   REFERENCE   BIOSURGERY
                                                  ----------   -----------   -----------   ---------   ----------
                                                                                        
Revenues:
  Net product sales.............................   $ 48,624       $   613      $  (571)       F24       $ 48,666
  Net service sales.............................      5,528            --                                  5,528
  Collaborative research and development
    revenue.....................................         --           249         (249)       F25             --
  Revenue from research and development
    contracts...................................          4            --           --                         4
                                                   --------       -------      -------                  --------
    Total revenues..............................     54,156           862         (820)                   54,198
                                                   --------       -------      -------                  --------
Operating costs and expenses:
  Cost of products sold.........................     28,638           771         (429)       F24         28,980
  Cost of services sold.........................      3,137            --                                  3,137
  Selling, general and administrative...........     30,692         1,446          217        F23         32,355
  Research and development......................     10,719         1,369                                 12,088
  Amortization of intangibles...................     11,321            --           80        F22         11,401
                                                   --------       -------      -------                  --------
    Total operating costs and expenses..........     84,507         3,586         (132)                   87,961
                                                   --------       -------      -------                  --------
Operating loss..................................    (30,351)       (2,724)        (688)                  (33,763)
                                                   --------       -------      -------                  --------
Other income (expense):
  Equity in net loss of unconsolidated
    affiliates..................................       (536)           --          536        F24             --
  Other.........................................          7            --           --                         7
  Investment income.............................        512            99           --                       611
  Interest expense..............................     (4,959)           --           --                    (4,959)
                                                   --------       -------      -------                  --------
    Total other income (expense)................     (4,976)           99          536                    (4,341)
                                                   --------       -------      -------                  --------
Division net loss...............................   $(35,327)      $(2,625)     $  (152)                 $(38,104)
                                                   ========       =======      =======                  ========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS

                                       16

                               GENZYME BIOSURGERY

                       A DIVISION OF GENZYME CORPORATION

                   UNAUDITED PRO FORMA COMBINED BALANCE SHEET

                              AS OF MARCH 31, 2001
                             (AMOUNTS IN THOUSANDS)



                                                     HISTORICAL                                           PRO FORMA
                                                      GENZYME     HISTORICAL     PRO FORMA      NOTE       GENZYME
                                                     BIOSURGERY   FOCAL, INC.   ADJUSTMENTS   REFERENCE   BIOSURGERY
                                                     ----------   -----------   -----------   ---------   ----------
                                                                                           
ASSETS
Current assets:
  Cash and cash equivalents........................   $ 21,548     $  5,490      $    (507)      F15       $ 26,531
  Short-term investments...........................         --          201             --                      201
  Accounts receivable, net.........................     39,588          432           (370)      F18         39,650
  Inventories......................................     57,460        1,511          5,078       F21         64,049
  Prepaid expenses and other current assets........      9,590          406             --                    9,996
                                                      --------     --------      ---------                 --------
    Total current assets...........................    128,186        8,040          4,201                  140,427
Property, plant and equipment, net.................     56,835        2,020             --                   58,855
Notes receivable, related party....................         --          174            (37)      F17            137
Intangibles, net...................................    576,970           --          3,817       F15        580,787
Other noncurrent assets............................      8,140           --          2,600       F19
                                                                                    (6,165)      F18          4,575
                                                      --------     --------      ---------                 --------
    Total assets...................................   $770,131     $ 10,234      $   4,416                 $784,781
                                                      ========     ========      =========                 ========

LIABILITIES AND DIVISION EQUITY
Current liabilities:
  Accounts payable.................................   $  9,794     $    278             --                 $ 10,072
  Accrued expenses.................................     34,719        1,909            700       F16
                                                                                     1,125       F16         38,453
Due to Genzyme General.............................     17,459           --             --                   17,459
Deferred revenue...................................         --          883           (883)      F20             --
Current portion of notes payable, long-term debt
  and capital lease obligations....................     18,421          600             --                   19,021
                                                      --------     --------      ---------                 --------
    Total current liabilities......................     80,393        3,670            942                   85,005
Convertible notes..................................     10,000           --             --                   10,000
Notes payable, long-term debt and capital lease
  obligations......................................    200,887          535             --                  201,422
Deferred revenue--noncurrent.......................         --        3,800         (3,800)      F20             --
Other noncurrent liabilities.......................         77           --             --                       77
                                                      --------     --------      ---------                 --------
    Total liabilities..............................    291,357        8,005         (2,858)                 296,504
                                                      --------     --------      ---------                 --------
Division equity:
  Focal common stock...............................                     174           (174)      F17             --
  Focal additional-paid in capital.................                 100,344       (100,344)      F17             --
  Focal notes receivable--related parties..........                    (420)           420       F17             --
  Focal retained earnings..........................                 (97,870)        97,870       F17             --
  Focal other comprehensive loss...................                       1             (1)      F17             --
  Division equity..................................    478,774           --             21       F15
                                                                                     9,513       F15
                                                                                       389       F15
                                                                                      (420)      F17        488,277
                                                      --------     --------      ---------                 --------
Total division equity..............................    478,774        2,229          7,274                  488,277
                                                      --------     --------      ---------                 --------
    Total liabilities and division equity..........   $770,131     $ 10,234      $   4,416                 $784,781
                                                      ========     ========      =========                 ========


             SEE NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS

                                       17

               NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS

(1) ACCOUNTING POLICIES AND PRO FORMA INFORMATION

    The unaudited pro forma combined financial statements reflect the pro forma
effect of Genzyme's merger with Focal and Genzyme's purchase of Wyntek's common
stock on the:

    - unaudited statements of operations for the three months ended March 31,
      2001 and the year ended December 31, 2000 and

    - unaudited balance sheet as of March 31, 2001

of both Genzyme and Genzyme Biosurgery, the division of Genzyme to which the
assets, liabilities and operations of Focal will be allocated.

    The pro forma balance sheets give effect to Genzyme's transactions with
Focal and Wyntek as if they occurred on March 31, 2001.

    The unaudited pro forma combined financial statements also reflect the pro
forma effect of Genzyme's merger with GelTex and Genzyme's merger with Biomatrix
on the unaudited statement of operations for the year ended December 31, 2000 of
both Genzyme and Genzyme Biosurgery, the division of Genzyme to which the
assets, liabilities and operations of Biomatrix were allocated, as if these
mergers took place on January 1, 2000. In addition, the Genzyme pro forma
statement of operations for the year ended December 31, 2000 reflects the change
in earnings allocations resulting from the creation of Biosurgery Stock and
elimination of Surgical Products Stock and Tissue Repair Stock as if this change
took place on January 1, 2000.

(2) GENZYME'S ACQUISITIONS

    (A) GENZYME'S ACQUISITION OF BIOMATRIX

    Genzyme entered into the merger agreement to acquire Biomatrix on March 6,
2000. Concurrently with the merger:

    - Genzyme Biosurgery was created as a new division of Genzyme;

    - the businesses of Genzyme Surgical Products and Genzyme Tissue Repair were
      reallocated to Genzyme Biosurgery; and

    - the businesses of Biomatrix was allocated to Genzyme Biosurgery.

    The following exchange ratios were used to determine the number of shares of
Biosurgery Stock distributed:

    - 0.6060 multiplied by the number of shares of Surgical Products Stock
      outstanding;

    - 0.3352 multiplied by the number of shares of Tissue Repair Stock
      outstanding; and

    - 0.7162 multiplied by the number of Biomatrix shares outstanding (based on
      a one-for-one exchange ratio for 71.62% of the Biomatrix shares).

This resulted in approximately:

    - 9,092,763 shares of Biosurgery Stock exchanged for 15,004,560 shares of
      Surgical Products Stock;

    - 9,679,769 shares of Biosurgery Stock exchanged for 28,877,593 shares of
      Tissue Repair Stock; and

                                       18

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(2) GENZYME'S ACQUISITIONS (CONTINUED)
    - 17,516,712 shares of Biosurgery Stock and approximately $252.4 million of
      cash, exchanged for 24,338,908 shares of Biomatrix common stock.

In addition, options to purchase:

    - 3,252,386 shares of Surgical Products Stock under the Genzyme equity
      plans;

    - 3,923,281 shares of Tissue Repair Stock under the Genzyme equity plans;
      and

    - 1,706,639 shares of Biomatrix common stock under the Biomatrix equity
      plans

converted to options to purchase approximately 1,970,944, 1,315,083, and
1,222,300 shares of Biosurgery Stock, respectively. Using the acquisition price
of Biomatrix common stock and certain other assumptions in the Black-Scholes
option valuation model, the Biosurgery options issued in exchange for the
Biomatrix options have been valued at approximately $11.4 million. In accordance
with FIN 44, the intrinsic value of the portion of the unvested options related
to the future service period of approximately $66,000 was allocated to deferred
compensation in stockholders' equity for Genzyme or division equity for Genzyme
Biosurgery, rather than to goodwill. The unvested portion is being amortized to
operating expense over the remaining vesting periods of approximately three
years.

    (B) GENZYME'S ACQUISITION OF GELTEX

    Genzyme entered into a merger agreement to acquire GelTex on September 11,
2000. Genzyme paid approximately $515.2 million in cash and issued
$491.2 million in Genzyme General Stock for all of the outstanding shares of
GelTex common stock, using the stock price of Genzyme General Stock based on the
average trading price over three days before and after the September 11, 2000
announcement of the merger. Approximately 7.9 million shares of Genzyme General
Stock were issued in exchange for shares of GelTex common stock. In addition,
options and warrants to purchase approximately 2.1 million shares of GelTex
common stock were exchanged for options and warrants to purchase approximately
1.6 million shares of Genzyme General Stock. The vesting of GelTex options
granted to employees of GelTex before the effective date of the merger will be
accelerated as of the first anniversary of the effective date of the merger as
long as they remain employees of GelTex or Genzyme on the one year anniversary
date. Additionally, the vesting of stock options granted to directors and
several officers of GelTex were accelerated immediately upon the effective time
of the merger. Using the Black-Scholes valuation model, the options and warrants
to purchase Genzyme General Stock issued in exchange for the GelTex options and
warrants had a value of approximately $62.9 million. In accordance with FIN 44,
the intrinsic value of the portion of the unvested options related to the future
service period of $10.2 million was allocated to deferred compensation in
stockholders' equity for Genzyme. The unvested portion is being amortized to
operating expense over the remaining vesting period of approximately one year.

    (C) GENZYME'S PENDING ACQUISITION OF FOCAL

    Genzyme entered into a merger agreement to acquire Focal on April 25, 2001.
For purposes of the unaudited pro forma financial statements, we assumed that
Genzyme would issue approximately 2,086,000 shares of Biosurgery Stock and
approximately $7,000 in cash for all of the outstanding shares of Focal common
stock excluding shares owned by Genzyme which will be cancelled in the merger.
Using the price of Biosurgery Stock based on the average trading price over
three days before and after April 25, 2001, the value of the shares of
Biosurgery Stock would be approximately $9.5 million. In addition, options to
purchase 1,742,664 shares of Focal common stock and warrants to purchase 43,782
shares of Focal common stock will be exchanged for options to purchase
approximately 276,705

                                       19

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(2) GENZYME'S ACQUISITIONS (CONTINUED)
shares of Biosurgery Stock. Using the Black-Scholes valuation model, the options
and warrants to purchase Biosurgery Stock issued in exchange for options and
warrants to purchase Focal common stock have a value of approximately $389,000.
In accordance with FIN 44, any intrinsic value of the portion of the unvested
options related to future service periods would be allocated to deferred
compensation in stockholders' equity for Genzyme. Based on the value of
Biosurgery Stock on April 25, 2001, there was no intrinsic value allocated to
deferred compensation.

    (D) GENZYME'S PENDING ACQUISITION OF WYNTEK

    Genzyme entered into a stock purchase agreement on April 30, 2001 to acquire
all or substantially all of the outstanding capital stock of Wyntek. For
purposes of the unaudited pro forma financial statements, we assumed that
Genzyme would pay $65.0 million in cash for all of the outstanding Wyntek common
stock and all outstanding options to acquire Wyntek common stock. No options or
warrants to purchase Wyntek common stock will be assumed by Genzyme in the
transaction.

(3)  PURCHASE PRICE ALLOCATION

    (A) BIOMATRIX

    The aggregate purchase price of $482.4 million was allocated to the acquired
tangible and intangible assets and liabilities based on their estimated
respective fair values as of December 18, 2000 (amounts in thousands):


                                                           
Cash and cash equivalents...................................  $  56,137
Current assets..............................................     37,639
Property, plant & equipment.................................     38,479
Notes receivable from stockholders..........................     14,760
Intangible assets (to be amortized over 1.5 to 11.0
  years)....................................................    284,854
Goodwill (to be amortized over 11.0 years)..................    112,262
In-process research and development.........................     82,143
Deferred tax asset..........................................        922
Deferred compensation.......................................         66
Assumed liabilities.........................................    (31,099)
Liabilities for exit activities and integration.............     (6,716)
Deferred tax liability......................................   (107,044)
                                                              ---------
  Aggregate purchase price..................................  $ 482,403
                                                              =========


    In connection with the purchase of Biomatrix, Genzyme allocated
approximately $82.1 million of the purchase price to in-process research and
development, or IPR&D. Genzyme management assumes responsibility for determining
the IPR&D valuation. Genzyme engaged an independent third-party appraisal
company to assist in the valuation of the intangible assets acquired. For a
complete description of the allocation of the purchase price to the fair value
of the acquired tangible and intangible assets and liabilities, refer to Note
D., "Acquisitions" to Genzyme's consolidated financial statements included in
Genzyme's Annual Report on Form 10-K for the year ended December 31, 2000.

                                       20

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(3)  PURCHASE PRICE ALLOCATION (CONTINUED)
    (B) GELTEX

    The aggregate purchase price of $1,076.0 million was allocated to the
acquired tangible and intangible assets and liabilities based on their estimated
respective fair value as of December 14, 2000 (amounts in thousands):


                                                           
Cash and investments........................................  $  142,994
Current assets..............................................      32,825
Property, plant & equipment.................................      45,477
Intangible assets (to be amortized over 5 to 15 years)......     465,109
Goodwill (to be amortized over 15 years)....................     449,634
In-process research and development.........................     118,048
Deferred tax asset..........................................      35,016
Deferred compensation.......................................      10,206
Assumed liabilities.........................................     (47,789)
Deferred tax liability......................................    (175,485)
                                                              ----------
  Aggregate purchase price..................................  $1,076,035
                                                              ==========


    As part of the acquisition of GelTex, Genzyme acquired all of GelTex's
interest in RenaGel LLC, a joint venture between Genzyme and GelTex. Prior to
the acquisition of GelTex, Genzyme accounted for its investment in RenaGel LLC
under the equity method. The adjustments below also reflect the consolidation of
RenaGel LLC into Genzyme's financial statements and accounting for the purchase
by Genzyme of GelTex's 50%-interest in the joint venture using the purchase
method of accounting. The assets and liabilities of the joint venture are
reflected in the amounts above. Because Genzyme already owned a 50% interest in
RenaGel LLC, the assets of RenaGel LLC were adjusted to fair value only to the
extent of the 50%-interest Genzyme acquired.

    In connection with the purchase of GelTex, Genzyme expects approximately
$118.0 million of the purchase price to be allocated to IPR&D. Genzyme
management assumes responsibility for determining the IPR&D valuation. Genzyme
engaged an independent third-party appraisal company to assist in the valuation
of the intangible assets acquired. For a complete description of the allocation
of the purchase price to the fair value of the acquired tangible and intangible
assets and liabilities, refer to Note D., "Acquisitions" to Genzyme's
consolidated financial statements included in Genzyme's Annual Report on
Form 10-K for the year ended December 31, 2000.

                                       21

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(3)  PURCHASE PRICE ALLOCATION (CONTINUED)
    (C) FOCAL

    For purposes of the unaudited pro forma financial statements, the aggregate
purchase price of $16.6 million was allocated to the acquired tangible and
intangible assets and liabilities based on their estimated respective fair
values as of March 31, 2001 (amounts in thousands):


                                                           
Cash and cash equivalents...................................  $  5,490
Current assets..............................................     7,258
Property, plant & equipment.................................     2,020
Notes receivable from related party.........................       420
Intangible assets (to be amortized over 12 years)...........     3,817
Other assets................................................     2,737
Assumed liabilities.........................................    (5,147)
                                                              --------
  Aggregate purchase price..................................  $ 16,595
                                                              ========


    The total purchase price, the fair value of assets and liabilities acquired,
the allocation of purchase price and the lives of intangible assets will be
determined upon completion of the merger and may vary from the amounts presented
herein.

    (D) WYNTEK

    For purposes of the unaudited pro forma financial statements, the aggregate
purchase price of $65.7 million was allocated to the acquired tangible and
intangible assets and liabilities based on their estimated respective fair
values as of March 31, 2001 (amounts in thousands):


                                                           
Cash and cash equivalents...................................  $ 4,779
Current and other assets....................................    6,375
Property, plant & equipment.................................    1,970
Intangible assets (to be amortized over 5 to 10 years)......   34,924
Goodwill (to be amortized over 10 years)....................   14,198
In-process research and development.........................    7,866
Assumed liabilities.........................................   (4,462)
                                                              -------
  Aggregate purchase price..................................  $65,650
                                                              =======


    The total purchase price, the fair value of assets and liabilities acquired,
the allocation of purchase price and the lives of intangible assets will be
determined upon completion of the transaction and may vary from the amounts
presented herein.

    In connection with the purchase of Wyntek stock, Genzyme expects
approximately $7.9 million of the purchase price to be allocated to IPR&D.
Genzyme management assumes responsibility for determining the IPR&D valuation
and expects the final valuation will be completed upon closing the transaction.
The fair value assigned to purchased IPR&D was estimated by discounting, to
present value, the cash flows expected to result from the project once it has
reached technological feasibility. A discount rate consistent with the risks of
the project was used to estimate the present value of cash flows. In estimating
future cash flows, management considered other tangible and intangible assets
required for successful exploitation of the technology resulting from the
purchased IPR&D project and adjusted future cash flows for a charge reflecting
the contribution to value of these assets. The value assigned to purchased IPR&D
was the amount attributable to the efforts of Wyntek up to the time of

                                       22

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(3)  PURCHASE PRICE ALLOCATION (CONTINUED)
acquisition. This amount was estimated through application of the "stage of
completion" calculation by multiplying total estimated revenue for IPR&D by the
percentage of completion of the purchased research and development project at
the time of acquisition.

    The nature of the efforts to develop the purchased IPR&D into commercially
viable products, principally relates to the completion and/or acceleration of
existing development programs, including the mandatory completion of several
phases of clinical trials and the costs necessary to manage the projects and
trials. Assuming the approval of the product by the FDA, costs related to the
wide scale manufacturing, distribution, and marketing of the product are
included in the projection. The resulting net cash flows from such project are
based on Genzyme management's estimates of revenues, cost of sales, research and
development expenses, sales and marketing expenses, general and administrative
expenses, and the anticipated income tax effect.

    The discounting of net cash flows back to their present value is based on
the weighted average cost of capital, or WACC. The WACC calculation produces the
average required rate of return of an investment in an operating enterprise,
based on various required rates of return from investments in various areas of
that enterprise. The discount rate utilized in discounting the net cash flows
from purchased IPR&D was 25%. This discount rate is higher than Genzyme's WACC
due to the inherent uncertainties surrounding the successful development of the
purchased IPR&D.

    The forecast data employed in the analyses was based upon product level
forecast information obtained by Genzyme from numerous internal and external
resources. These resources included external market research and internal
experts. Genzyme senior management reviewed and challenged the forecast data and
related assumptions and utilized the information in analyzing IPR&D. The
forecast data and assumptions are inherently uncertain and unpredictable.
However, based upon the information available at this time, Genzyme management
believes the forecast data and assumptions to be reasonable. These assumptions
may be incomplete or inaccurate, and no assurance can be given that
unanticipated events and circumstances will not occur. Accordingly, actual
results may vary from the forecasted results. Any such variance may result in a
material adverse effect on Genzyme's financial condition and results of
operations.

    In the allocation of purchase price to the IPR&D, the concept of alternative
future use was specifically considered for the program under development. The
acquired IPR&D consists of Wyntek's work to complete the program. There are no
alternative uses for the in-process program in the event that the program fails
in clinical trials or is otherwise not feasible. The development effort for the
acquired IPR&D does not possess an alternative future use for Genzyme as defined
by generally accepted accounting principles.

    Below is a brief description of the IPR&D program associated with Wyntek's
cardiovascular disease diagnostic product, including an estimation of when
management believes Genzyme may realize revenues from the sale of this product.

    Wyntek is currently developing a cardiovascular product to rapidly measure
the quantitative levels of cardiac marker proteins. These are the leading
markers for the diagnosis of Acute Myocardial Infraction. The product consists
of a mobile, stand-alone, quantitative diagnostic device and a reaction strip
that detects disease specific marker proteins. The device will be used to read
reaction strips at the patient's bedside or in an emergency room setting. Wyntek
expects to complete the regulatory review process and file the PMA early in 2002
and begin selling the product during the second half of 2002. Studies to date
have demonstrated the viability of this product but there can be no assurance
that the

                                       23

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(3)  PURCHASE PRICE ALLOCATION (CONTINUED)
regulatory authorities will approve this product. A discount rate of 25% was
used in valuing the projected cash flows.

(4)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF BIOMATRIX

    These adjustments reflect the retirement of all Surgical Products Stock,
Tissue Repair Stock and Biomatrix common stock and the issuance of Biosurgery
Stock. The value ascribed to the Biosurgery Stock exchanged for Biomatrix common
stock for purchase price accounting is $11.79 per share.

    The aggregate purchase price is comprised of the following (amounts in
thousands):


                                                           
Issuance of 17,516,712 shares of Biosurgery Stock...........  $206,522
Cash payment................................................   252,421
                                                              --------
  Subtotal..................................................   458,943
Issuance of Biosurgery options to Biomatrix optionholders...    11,373
Acquisition costs...........................................    12,087
                                                              --------
        Aggregate purchase price............................  $482,403
                                                              ========


    I. PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED STATEMENT OF
     OPERATIONS

   (B1) To record the amortization of acquired intangible assets and goodwill
        (amounts in thousands):



                                                        ASSIGNED      ANNUAL
                                                         VALUE     AMORTIZATION
                                                        --------   ------------
                                                             
INTANGIBLE ASSETS:
  Workforce (5 years).................................  $  2,017      $   404
  Non-compete agreements (1.5 years)..................       640          427
  Distribution agreements (8 years)...................    13,950        1,744
  Trademark/trade name (11 years).....................    48,746        4,431
  Patented core technology (11 years).................    59,877        5,443
  Current products technology (11 years)..............   159,624       14,511
  Goodwill (11 years).................................   112,262       10,206
                                                        --------      -------
    Pro forma adjustment for amortization of
      intangibles.....................................  $397,116      $37,166
                                                        ========      =======


   (B2) To record the following:

       - Amortization of deferred compensation associated with Genzyme
         Biosurgery options that were issued in exchange for Biomatrix options;

       - Impact of the additional expense associated with the increased basis
         for the Biomatrix inventory;

       - Impact of the reduced depreciation expense related to the decreased
         basis of Biomatrix's fixed assets.

   (B3) To eliminate Biomatrix' weighted average shares outstanding, and to
        record the cancellation of Surgical Products Stock and Tissue Repair
        Stock. Also gives effect to the conversion of Surgical Products Stock
        and Tissue Repair Stock into Biosurgery Stock as though the tracking

                                       24

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(4)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF BIOMATRIX (CONTINUED)
       stock exchanges occurred on January 1, 2000, and to the issuance of
        Biosurgery Stock for Biomatrix common stock as though the Biomatrix
        acquisition occurred on January 1, 2000.

   (B4) To record the creation of Biosurgery Stock. Net losses for Genzyme
        Surgical Products and Genzyme Tissue Repair and net income for Biomatrix
        have been transferred to the calculation of loss per share allocated to
        Biosurgery Stock. The net income amount for Biomatrix of $7.1 million
        for the year ended December 31, 2000 reflects the elimination of the
        $6.5 million tax provision because Genzyme Biosurgery incurred a pro
        forma net loss for each period.

   (B5) To adjust the tax provision for the impact of the amortization of
        acquired intangibles, the reduction in investment income, the additional
        interest expense and the amortization of the deferred tax liability
        established in purchase accounting. Income taxes are allocated to
        Genzyme Biosurgery based upon the financial statement income, taxable
        income, credits and other amounts properly allocable to each division
        under generally accepted accounting principles as if it were a separate
        taxpayer. The realizability of deferred tax assets is assessed at the
        division level.

   (B6) To record interest expense that would have been incurred on the $200.0
        million of debt, at a rate of 7.5% per annum; and to reduce the
        investment income balance to reflect the payment of $52.4 million of
        cash at a rate of return of 5.45% per annum.

   (B7) To allocate the pro forma tax benefits of Genzyme Biosurgery to Genzyme
        General. Genzyme's management and accounting policies provide that, if
        as of the end of any fiscal quarter, a division can not use any
        projected annual tax benefit attributable to it to offset or reduce its
        current or deferred income tax expense, Genzyme may allocate the tax
        benefit to other divisions in proportion to their taxable income without
        any compensating payments or allocation to the division generating the
        benefit. The tax benefits allocated to Genzyme General from Genzyme
        Biosurgery totaled $28.0 million for the year ended December 31, 2000.
        On a pro forma basis, the tax benefits allocated to Genzyme General from
        Genzyme Biosurgery would have been $27.7 million for the year ended
        December 31, 2000. The tax benefits generated by Genzyme Biosurgery and
        allocated to Genzyme General are lower on a pro forma basis due
        primarily to Biomatrix' profitability offsetting losses incurred by
        Genzyme Biosurgery.

   (B8) To eliminate the charge for acquired in-process research and development
        recorded by Genzyme in connection with the acquisition. This amount was
        eliminated as it reflects a material non-recurring charge directly
        resulting from the acquisition.

   (B9) To record the tax benefits related to the Biomatrix pro forma
        adjustments which are allocated to Genzyme Biosurgery.

                                       25

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(4)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF BIOMATRIX (CONTINUED)
    II. PRO FORMA ADJUSTMENTS TO GENZYME BIOSURGERY'S COMBINED STATEMENT OF
     OPERATIONS

  (B10) To record the amortization of acquired intangible assets and goodwill
        (amounts in thousands):



                                                        ASSIGNED      ANNUAL
                                                         VALUE     AMORTIZATION
                                                        --------   ------------
                                                             
INTANGIBLE ASSETS:
  Workforce (5 years).................................  $  2,017      $   404
  Non-compete agreements (1.5 years)..................       640          427
  Distribution agreements (8 years)...................    13,950        1,744
  Trademark/trade name (11 years).....................    48,746        4,431
  Patented core technology (11 years).................    59,877        5,443
  Current products technology (11 years)..............   159,624       14,511
  Goodwill (11 years).................................   112,262       10,206
                                                        --------      -------
      Pro forma adjustment for amortization of
        intangibles...................................  $397,116      $37,166
                                                        ========      =======


  (B11) To record the following:

       - Amortization of deferred compensation associated with Genzyme
         Biosurgery options that were issued in exchange for Biomatrix options;

       - Impact of the additional expense associated with the increased basis
         for the Biomatrix inventory;

       - Impact of the reduced depreciation expense related to the decreased
         basis of Biomatrix's fixed assets.

  (B12) To eliminate the tax provision because Genzyme Biosurgery incurred a pro
        forma net loss for each period.

  (B13) To record interest expense that would have been incurred on the $200.0
        million of debt, at a rate of 7.5% per annum; and to reduce the
        investment income balance to reflect the payment of $52.4 million of
        cash at a rate of return of 5.45% per annum.

  (B14) To eliminate the charge for acquired in-process research and development
        recorded by Genzyme in connection with the acquisition. This amount was
        eliminated as it reflects a material non-recurring charge directly
        resulting from the acquisition.

(5)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF GELTEX

    The following adjustments reflect the acquisition of GelTex by Genzyme for a
combination of cash and stock and the replacement of GelTex options and warrants
with options and warrants to purchase Genzyme General Stock. As part of the
acquisition of GelTex, Genzyme acquired all of GelTex's interest in RenaGel LLC,
a joint venture between Genzyme and GelTex. Prior to the acquisition of GelTex,
Genzyme accounted for its investment in RenaGel LLC under the equity method. The
adjustments below reflect the consolidation of RenaGel LLC into Genzyme's
financial statements and accounting for Genzyme's purchase of GelTex' interest
in the joint venture using the purchase method of accounting.

                                       26

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(5)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF GELTEX (CONTINUED)
    To record the acquisition of the net assets of GelTex for an aggregate
purchase price of $1,076.0 million. The aggregate purchase price is comprised of
the following (amounts in thousands):


                                                           
Issuance of 7,886,404 shares of Genzyme General Stock.......  $  491,181
Cash payment................................................     515,151
                                                              ----------
Subtotal....................................................   1,006,332
Basis of GelTex investment..................................       2,500
Issuance of Genzyme General options and warrants to GelTex
  option and warrant holders................................      62,882
Acquisition costs...........................................       4,321
                                                              ----------
Aggregate purchase price....................................  $1,076,035
                                                              ==========


    I.  PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED STATEMENTS OF
     OPERATIONS

  (G1) To record the amortization of acquired intangible assets and goodwill
       (amounts in thousands):



                                                ASSIGNED VALUE   ANNUAL AMORTIZATION
                                                --------------   -------------------
                                                           
INTANGIBLE ASSETS:
  Workforce (5 years).........................     $  2,327            $   465
  Patents (15 years)..........................      115,772              7,718
  Trademarks/trade name (15 years)............        6,526                435
  Core technology (15 years)..................       65,313              4,354
  Current products technology (5 to 15
    years)....................................      275,171             19,948
  Goodwill (15 years).........................      449,634             29,976
                                                   --------            -------
  Pro forma adjustment for amortization of
    intangibles...............................     $914,743            $62,896
                                                   ========            =======


  (G2) To record the following:

       - Amortization of deferred compensation associated with Genzyme General
         options that were issued in exchange for GelTex options;

       - Impact of the additional expense associated with the increased basis
         for the Renagel LLC inventory of $8.2 million;

       - Impact of the additional depreciation expense related to the increased
         basis of GelTex's fixed assets.

  (G3) To eliminate GelTex's weighted average shares outstanding, to reflect the
       issuance of 7,886,404 shares of Genzyme General Stock and to reflect the
       dilutive effect of the issuance of options to purchase Genzyme General
       Stock to holders of GelTex options.

  (G4) To record interest expense that would have been incurred on the $150.0
       million of debt, at a rate of 7.5% per annum; to record the amortization
       of the value of the acquired interest rate swaps; and to reduce the
       investment income balance to reflect the payment of $365.2 million of
       cash at a rate of return of 5.45% per annum.

  (G5) To eliminate intercompany transactions between Genzyme, GelTex and
       RenaGel LLC.

                                       27

               NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS

(5)  PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF GELTEX (CONTINUED)

  (G6) To eliminate Genzyme's and GelTex's equity in the net loss of RenaGel LLC
       and to consolidate RenaGel LLC with Genzyme.

  (G7) To adjust the tax provision for the impact of the reduction in investment
       income, the additional interest expense and the amortization of the
       deferred tax liability established in purchase accounting.

  (G8) The net loss of GelTex has been transferred to the calculation of net
       income per share allocated to Genzyme General Stock. The adjustment to
       Genzyme General net income in the calculation of income allocated to
       Genzyme General Stock reflects the aggregate impact of all pro forma
       adjustments on the Genzyme General division net income.

  (G9) To eliminate the charge for acquired in-process research and development
       recorded by the Company in connection with the acquisition. This amount
       was eliminated as it reflects a material non-recurring charge directly
       resulting from the acquisition.

(6) PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF FOCAL

    The following adjustments reflect the acquisition of outstanding Focal
common stock not already owned by Genzyme for a combination of cash and stock
and the replacement of Focal options and warrants with options and warrants to
purchase Biosurgery Stock.

    The aggregate purchase price is comprised of the following (amounts in
thousands):


                                                           
Issuance of 2,086,151 shares of Biosurgery Stock............  $ 9,534
Cash payment................................................        7
                                                              -------
  Subtotal..................................................    9,541
Issuance of Biosurgery options to Focal optionholders.......      389
Acquisition costs...........................................      500
Basis of Focal investment...................................    6,165
                                                              -------
        Aggregate purchase price............................  $16,595
                                                              =======


I. PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED BALANCE SHEET

   (F1) To record the acquisition of the net assets of Focal for an aggregate
        purchase price of $16.6 million (see Note 2C). The intangible assets of
        approximately $3.8 million are as follows (amounts in thousands):



                                                               ASSIGNED
DESCRIPTION                                                     VALUE
- -----------                                                   ----------
                                                           
Patented core technology (12 years).........................   $    142
Current products technology (12 years)......................      3,675
                                                               --------
    Total...................................................   $  3,817
                                                               ========


       The purchase price includes $389,000 for the estimated fair value of the
       Genzyme Biosurgery options that were issued in exchange for the Focal
       options. This estimated fair value was calculated using the Black-Scholes
       option pricing model based on a stock price of $4.57, which

                                       28

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(6) PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF FOCAL (CONTINUED)
       is the value ascribed to the Biosurgery Stock for purchase price
       accounting, and other assumptions in the Black-Scholes model. No unvested
       options have intrinsic value that would require allocation to deferred
       compensation.

   (F2) To record $1.1 million of accrued expenses related to Focal's estimated
        acquisition costs and $700,000 related to management bonuses that have
        not been reflected in the historical balances as of March 31, 2001.

   (F3) To eliminate Focal historical stockholders' equity amounts totaling
        $2.2 million, except for the Focal notes receivable of $420,000, which
        will remain outstanding upon completion of the transaction. Focal
        received these notes in exchange for the purchase of Focal common stock.
        Also to give effect to the forgiveness of accrued interest totaling
        approximately $37,000 by Focal prior to the merger.

   (F4) To record inventory of Focal at fair value, by increasing the inventory
        by $5.1 million. The increased basis for the inventory valuation will
        result in a $5.1 million decrease in gross margin as the units are sold,
        after the acquisition.

   (F5) To eliminate the $6.2 million carrying value of Genzyme's existing
        investment in Focal. Also to eliminate Focal's accounts receivable from
        Genzyme totaling $370,000.

   (F6) To record the fair value of favorable lease arrangements to which Focal
        is party.

   (F7) To eliminate deferred revenue recorded by Focal that will not require
        Genzyme to incur any significant costs.

II. PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED STATEMENTS OF
  OPERATIONS

   (F8) To record the amortization of acquired intangible assets and goodwill
        (amounts in thousands):



                                             ASSIGNED      ANNUAL       QUARTERLY
                                              VALUE     AMORTIZATION   AMORTIZATION
                                             --------   ------------   ------------
                                                              
INTANGIBLE ASSETS:
  Patented care technology (12 years)......  $    142      $    12          $ 3
  Current products technology (12 years)...     3,675          306           77
                                             --------      -------          ---
      Pro forma adjustment for amortization
        of intangibles.....................  $  3,817      $   318          $80
                                             ========      =======          ===


   (F9) To record the following:

       - Impact of the additional expense associated with the increased basis
         for the Focal inventory; and

       - Impact of additional expense for the favorable lease arrangement.

  (F10) To eliminate sales and cost of sales related to transactions between
        Genzyme and Focal. Also to eliminate the $7.3 million impairment charge
        recorded by Genzyme in the year ended December 31, 2000 related to its
        investment in Focal common stock, and to eliminate the equity in net
        loss of Focal recognized by Genzyme in the three months ended March 31,
        2001.

                                       29

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(6) PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF FOCAL (CONTINUED)
  (F11) To eliminate the cumulative effect of a change in accounting principle
        recorded by Focal upon adoption of Staff Accounting Bulletin No. 101,
        REVENUE RECOGNITION. The cumulative effect adjustment to record deferred
        revenue would not have been required if Focal had been acquired on
        January 1, 2000 and purchase accounting had been applied as of that
        date. Also to reverse the amortization of deferred revenue during the
        twelve months ended December 31, 2000 and the three months ended
        March 31, 2001.

  (F12) To adjust the tax provision for the net loss incurred by Focal and for
        the pro forma adjustments related to the Focal merger.

  (F13) To eliminate Focal's weighted average shares outstanding, and to give
        effect to the issuance of Biosurgery Stock for Focal common stock as
        though the merger occurred on January 1, 2000. The net loss of Focal has
        been transferred to the calculation of net loss per share allocated to
        Biosurgery Stock. The adjustment to Genzyme Biosurgery net loss in the
        calculation of income allocated to Biosurgery Stock reflects the
        aggregate impact of all pro forma adjustments on the Genzyme Biosurgery
        division net loss.

  (F14) To allocate the pro forma tax benefits of the Focal net losses and pro
        forma adjustments to Genzyme General. Genzyme's management and
        accounting policies provide that, if as of the end of any fiscal
        quarter, a division can not use any projected annual tax benefit
        attributable to it to offset or reduce its current or deferred income
        tax expense, Genzyme may allocate the tax benefit to other divisions in
        proportion to their taxable income without any compensating payments or
        allocation to the division generating the benefit.

III. PRO FORMA ADJUSTMENTS TO GENZYME BIOSURGERY'S COMBINED BALANCE SHEET

  (F15) To record the acquisition of the net assets of Focal for an aggregate
        purchase price of $16.6 million (see Note 2C). The intangible assets of
        approximately $3.8 million are as follows (amounts in thousands):



                                                               ASSIGNED
DESCRIPTION                                                     VALUE
- -----------                                                   ----------
                                                           
Patented core technology (12 years).........................       142
Current products technology (12 years)......................     3,675
                                                                ------
    Total...................................................    $3,817
                                                                ======


       The purchase price includes $389,000 for the estimated fair value of the
       Genzyme Biosurgery options that were issued in exchange for the Focal
       options. This estimated fair value was calculated using the Black-Scholes
       option pricing model based on a stock price of $4.57, which is the value
       ascribed to the Biosurgery Stock for purchase price accounting, and other
       assumptions in the Black-Scholes model. No unvested options have
       intrinsic value that would require allocation to deferred compensation.

  (F16) To record $1.1 million of accrued expenses related to Focal's estimated
        acquisition costs and $700,000 related to management bonuses that have
        not been reflected in the historical balances as of March 31, 2001.

  (F17) To eliminate Focal's historical stockholders' equity amounts totaling
        $2.2 million, except for the Focal notes receivable of $420,000, which
        will remain outstanding upon completion of the

                                       30

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(6) PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF FOCAL (CONTINUED)
       transaction. Focal received these notes in exchange for the purchase of
        Focal common stock. Also to give effect to the forgiveness of accrued
        interest totaling approximately $37,000 by Focal prior to the merger.

  (F18) To eliminate the $6.2 million carrying value of Genzyme's existing
        investment in Focal, which is allocated to Genzyme Biosurgery. Also to
        eliminate Focal's accounts receivable from Genzyme totaling $370,000.

  (F19) To record the fair value of favorable lease arrangements to which Focal
        is party.

  (F20) To eliminate deferred revenue recorded by Focal that will not require
        Genzyme Biosurgery to incur any additional costs.

  (F21) To record inventory of Focal at fair value, by increasing the inventory
        by $5.1 million. The increased basis for the inventory valuation will
        result in a $5.1 million decrease in gross margin as the units are sold,
        after the acquisition.

IV. PRO FORMA ADJUSTMENTS TO GENZYME BIOSURGERY'S COMBINED STATEMENTS OF
  OPERATIONS

  (F22) To record the amortization of acquired intangible assets and goodwill
        (amounts in thousands):



                                             ASSIGNED      ANNUAL       QUARTERLY
                                              VALUE     AMORTIZATION   AMORTIZATION
                                             --------   ------------   ------------
                                                              
INTANGIBLE ASSETS:
  Patented core technology (12 years)......  $    142      $    12          $ 3
  Current products technology (12 years)...     3,675          306           77
                                             --------      -------          ---
      Pro forma adjustment for amortization
        of intangibles.....................  $  3,817      $   318          $80
                                             ========      =======          ===


  (F23) To record the following:

       - Impact of the additional expense associated with the increased basis
         for the Focal inventory; and

       - Impact of additional expense for the favorable lease arrangement.

  (F24) To eliminate sales and cost of sales related to transactions between
        Genzyme Biosurgery and Focal. Also to eliminate the $7.3 million
        impairment charge recorded by Genzyme Biosurgery in the year ended
        December 31, 2000 related to its investment in Focal common stock and to
        eliminate the equity in net loss of Focal recognized by Genzyme
        Biosurgery in the three months ended March 31, 2001.

  (F25) To eliminate the cumulative effect of a change in accounting principle
        recorded by Focal upon adoption of Staff Accounting Bulletin No. 101,
        REVENUE RECOGNITION. The cumulative effect adjustment to record deferred
        revenue would not have been required if Focal had been acquired on
        January 1, 2000 and purchase accounting had been applied as of that
        date. Also to reverse the amortization of deferred revenue during the
        twelve months ended December 31, 2000 and the three months ended
        March 31, 2001.

                                       31

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

(7) PRO FORMA ADJUSTMENTS RELATED TO THE ACQUISITION OF WYNTEK STOCK

    The following adjustments reflects the acquisiton of Wyntek Stock for cash.

    The aggregate purchase price is comprised of the following (amounts in
thousands):


                                                           
Cash payment................................................  $ 65,000
Acquisition costs...........................................       650
                                                              --------
        Aggregate purchase price............................  $ 65,650
                                                              ========


I. PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED BALANCE SHEET

  (W1) To record the acquisition of the net assets of Wyntek for an aggregate
       purchase price of $65.7 million (see Note 2D). The intangible assets of
       approximately $49.1 million are as follows (amounts in thousands):



                                                               ASSIGNED
DESCRIPTION                                                     VALUE
- -----------                                                   ----------
                                                           
Workforce (5 years).........................................   $ 1,125
Patented core technology (10 years).........................       688
Current products technology (10 years)......................    33,111
Goodwill (10 years).........................................    14,198
                                                               -------
    Total...................................................   $49,122
                                                               =======


       The $7.9 million allocated to in-process technology has been charged to
       accumulated deficit for the purposes of the pro forma balance sheet
       presentation only and will be charged to expense in Genzyme's historical
       financial statements upon completion of the merger with Wyntek. The
       goodwill of $14.2 million consists of the excess of the purchase price
       over the fair market value of net assets acquired.

  (W2) To record $1.0 million of accrued expenses related to the estimated
       acquisition costs to be incurred by Wyntek that have not been reflected
       in the historical balances as of March 31, 2001.

  (W3) To record inventory of Wyntek at fair value, by increasing the inventory
       by $318,000. The increased basis for the inventory valuation will result
       in a $318,000 decrease in gross margin as the units are sold, after the
       acquisition.

  (W4) To reverse deferred tax assets recorded by Wyntek, as such assets will
       not be realizable by Genzyme following the merger.

  (W5) To eliminate Wyntek historical stockholders' equity amounts totaling
       $9.6 million.

                                       32

         NOTES TO UNAUDITED PRO FORMA FINANCIAL STATEMENTS (CONTINUED)

II. PRO FORMA ADJUSTMENTS TO GENZYME CORPORATION'S COMBINED STATEMENTS OF
  OPERATIONS

  (W6) To record the amortization of acquired intangible assets and goodwill
       (amounts in thousands):



                                              ASSIGNED      ANNUAL       QUARTERLY
                                               VALUE     AMORTIZATION   AMORTIZATION
                                              --------   ------------   ------------
                                                               
INTANGIBLE ASSETS:
  Workforce (5 years).......................  $ 1,125       $  225         $   56
  Patented core technology (10 years).......      688           69             17
  Current products technology (10 years)....   33,111        3,311            828
  Goodwill (10 years).......................   14,198        1,420            355
                                              -------       ------         ------
      Pro forma adjustment for amortization
        of intangibles......................  $49,122       $5,025         $1,256
                                              =======       ======         ======


  (W7) To record the impact of the additional expense associated with the
       increased basis for the Wyntek inventory.

  (W8) To reduce investment income to reflect the payment of $65.7 million of
       cash at a rate of return of 5.45% per annum.

  (W9) To adjust the tax provision for the impact of the Wyntek pro forma
       adjustments.

 (W10) To eliminate Wyntek's weighted average shares outstanding. The net income
       of Wyntek has been transferred to the calculation of net income per share
       allocated to Genzyme General Stock. The adjustment to Genzyme General net
       income in the calculation of income allocated to Genzyme General Stock
       reflects the aggregate impact of all pro forma adjustments on the Genzyme
       General division net income.

                                       33


                                  EXHIBIT INDEX

EXHIBIT
   NO.            DESCRIPTION

     2            Agreement and Plan of Merger, dated as of April 25, 2001,
                  among Genzyme Corporation, Sammy Merger Corp. and Focal, Inc.
                  Attached as Annex A to the proxy statement/prospectus
                  contained in Genzyme's registration statement on Form S-4 (No.
                  333-61296) filed with the SEC on May 21, 2001 and incorporated
                  herein by reference.

     23           Consent of Ernst & Young LLP.  Filed herewith.

     99.1         The audited financial statements of Focal as of December 31,
                  2000 and 1999 and for each of the three years in the period
                  ended December 31, 2000, including the report of independent
                  auditors dated January 31, 2001. Filed herewith.

     99.2         The unaudited financial statements of Focal as of and for the
                  three months ended March 31, 2001 and 2000. Filed herewith.