EXHIBIT 3.1

                  Certificate of Amendment and Restatement of the
                           CERTIFICATE OF DESIGNATIONS

                                  VERSICOR INC.


               Establishing a Series of Preferred Stock Designated
                  SERIES A JUNIOR PARTICIPATING PREFERRED STOCK


                  VERSICOR INC., a corporation duly organized and existing
under the laws of the State of Delaware (the "Corporation"), hereby certifies
as follows:

                  ONE: The Certificate of Incorporation of the Corporation
was originally filed with the Secretary of State of the State of Delaware
(the "Secretary of State") on May 2, 1995 under the name Sepracor
Combinatorial Chemistry Corporation.

                  TWO: Pursuant to Section 242 of the General Corporation Law
of the State of Delaware, this Certificate of Amendment and Restatement of
the Certificate of Designations amends and restates the Certificate of
Designations filed with the Secretary of State on July 6, 2001 to read as
follows:

                  FIRST: Pursuant to authority expressly vested in the Board of
Directors of the Corporation by the Fourth Amended and Restated Certificate of
Incorporation of the Corporation, filed with the Secretary of State on August 8,
2000 (the "Certificate"), the Board of Directors of the Corporation (the "Board
of Directors"), by resolution duly adopted at a meeting duly called and held on
June 7, 2001, classified and designated one million (1,000,000) shares (the
"Shares") of the Company's Preferred Stock (as such term is used in the
Certificate) as shares of Series A Junior Participating Preferred Stock, with
the preferences, conversion and other rights, voting powers, restrictions,
limitations as to dividends and other distributions, qualifications and terms
and conditions of redemption as set forth below.

                  SERIES A JUNIOR PARTICIPATING PREFERRED STOCK

                  Section 1. DESIGNATION AND AMOUNT. A class of Preferred Stock
designated the "Series A Junior Participating Preferred Stock," par value $0.01
per share, is hereby established. The number of authorized shares of such Series
A Preferred Stock shall be one million (1,000,000). The Series A Junior
Participating Preferred Stock shall constitute a separate class of capital stock
of the Corporation.

                  Section 2.  DIVIDENDS AND DISTRIBUTIONS.

                  (A) Subject to the prior and superior rights of the holders of
any shares of any series of Preferred Stock ranking prior and superior to the
shares of Series A Junior Participating Preferred Stock with respect to
dividends, the holders of shares of Series A Junior Participating Preferred
Stock shall be entitled to receive, when, as and if


authorized and declared by the Board of Directors out of funds legally available
for the purpose, quarterly dividends payable in cash on the 15th day of January,
April, July and October in each year, or the next following business day, if
such day is not a business day (each such date being referred to herein as a
"Quarterly Dividend Payment Date"), commencing on the first Quarterly Dividend
Payment Date after the first issuance of a share or fraction of a share of
Series A Junior Participating Preferred Stock, in an amount per share (rounded
to the nearest cent) equal to the greater of (a) One Dollar ($1) or (b) subject
to the provision for adjustment hereinafter set forth, one hundred (100) times
the aggregate per share amount of all cash dividends, and one hundred (100)
times the aggregate per share amount (payable in kind) of all non-cash dividends
or other distributions other than a dividend payable in shares of Common Stock
or a subdivision of the outstanding shares of Common Stock (by reclassification
or otherwise), declared on the Common Stock, par value $0.01 per share, of the
Corporation (the "Common Stock") since the immediately preceding Quarterly
Dividend Payment Date, or, with respect to the first Quarterly Dividend Payment
Date, since the first issuance of any share or fraction of a share of Series A
Junior Participating Preferred Stock. In the event the Corporation shall at any
time after July 9, 2001 (the "Rights Record Date") (i) authorize and declare any
dividend on Common Stock payable in shares of Common Stock, (ii) subdivide the
outstanding Common Stock, or (iii) combine the outstanding Common Stock into a
smaller number of shares, then in each such case the amount to which holders of
shares of Series A Junior Participating Preferred Stock were entitled
immediately prior to such event under clause (b) of the preceding sentence shall
be adjusted by multiplying such amount by a fraction the numerator of which is
the number of shares of Common Stock outstanding immediately after such event
and the denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

                  (B) The Corporation shall authorize and declare a dividend or
distribution on the Series A Junior Participating Preferred Stock as provided in
Paragraph (A) above immediately after it authorizes and declares a dividend or
distribution on the Common Stock (other than a dividend payable in shares of
Common Stock); PROVIDED, HOWEVER, that in the event no dividend or distribution
shall have been authorized and declared on the Common Stock during the period
between any Quarterly Dividend Payment Date and the next subsequent Quarterly
Dividend Payment Date, a dividend of One Dollar ($1) per share on the Series A
Junior Participating Preferred

                                       ii


Stock shall nevertheless be payable on such subsequent Quarterly Dividend
Payment Date.

                  (C) Dividends shall begin to accrue and be cumulative on
outstanding shares of Series A Junior Participating Preferred Stock from the
Quarterly Dividend Payment Date next preceding the date of issue of such shares
of Series A Junior Participating Preferred Stock, unless the date of issue of
such shares is prior to the record date for the first Quarterly Dividend Payment
Date, in which case dividends on such shares shall begin to accrue from the date
of issue of such shares, or unless the date of issue is a Quarterly Dividend
Payment Date or is a date after the record date for the determination of holders
of shares of Series A Junior Participating Preferred Stock entitled to receive a
quarterly dividend and before such Quarterly Dividend Payment Date, in either
event such dividends shall begin to accrue and be cumulative from such Quarterly
Dividend Payment Date. Accrued but unpaid dividends shall not bear interest.
Dividends paid on the shares of Series A Junior Participating Preferred Stock in
an amount less than the total amount of such dividends at the time accrued and
payable on such shares shall be allocated PRO RATA on a share-by-share basis
among all such shares at the time outstanding. The Board of Directors may fix a
record date for the determination of holders of shares of Series A Junior
Participating Preferred Stock entitled to receive payment of a dividend or
distribution authorized and declared thereon, which record date shall be no more
than thirty (30) days prior to the date fixed for the payment thereof.

                  Section 3. VOTING RIGHTS. The holders of shares of Series A
Junior Participating Preferred Stock shall have the following voting rights:

                  (A) Subject to the provision for adjustment hereinafter set
forth, each share of Series A Junior Participating Preferred Stock shall entitle
the holder thereof to one hundred (100) votes on all matters submitted to a vote
of the holders of the Common Stock. In the event the Corporation shall at any
time after the Rights Record Date (i) authorize and declare any dividend on
Common Stock payable in shares of Common Stock, (ii) subdivide the outstanding
Common Stock, or (iii) combine the outstanding Common Stock into a smaller
number of shares, then in each such case the number of votes per share to which
holders of shares of Series A Junior Participating Preferred Stock were entitled
immediately prior to such event shall be adjusted by multiplying such number by
a fraction the numerator of which is the number of shares of Common

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Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to
such event.

                  (B) Except as otherwise provided herein, the holders of shares
of Series A Junior Participating Preferred Stock and the holders of shares of
Common Stock shall vote together as one class on all matters submitted to a vote
of holders of the Common Stock.

                  (C) (i) If at any time dividends on any shares of Series A
         Junior Participating Preferred Stock shall be in arrears in an amount
         equal to six (6) quarterly dividends thereon, the occurrence of such
         contingency shall mark the beginning of a period (herein called a
         "default period") which shall extend until such time when all accrued
         and unpaid dividends for all previous quarterly dividend periods and
         for the current quarterly dividend period on all shares of Series A
         Junior Participating Preferred Stock then outstanding shall have been
         authorized and declared and paid or set apart for payment. During each
         default period, all holders of Preferred Stock (including holders of
         the Series A Junior Participating Preferred Stock) with dividends in
         arrears in an amount equal to six (6) quarterly dividends thereon,
         voting as a class, irrespective of series, shall have the right to
         elect two (2) directors.

                       (ii) During any default period, such voting right of the
         holders of Series A Junior Participating Preferred Stock may be
         exercised initially at a special meeting called pursuant to
         subparagraph (iii) of this Section 3(C) or at any annual meeting of
         stockholders, and thereafter at annual meetings of stockholders,
         provided that neither such voting right nor the right of the holders of
         any other series of Preferred Stock, if any, to increase, in certain
         cases, the authorized number of directors shall such voting right shall
         not be exercised unless the holders of ten percent (10%) in number of
         shares of Preferred Stock outstanding shall be present in person or by
         proxy. The absence of a quorum of the holders of Common Stock shall not
         affect the exercise by the holders of Preferred Stock of such voting
         right. At any meeting at which the holders of Preferred Stock shall
         exercise such voting right initially during an existing default period,
         they shall have the right, voting as a class, to elect directors to
         fill such vacancies, if any, in the Board of Directors as may then
         exist up to two (2)

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         directors or, if such right is exercised at an annual meeting, to elect
         two (2) directors. If the number which may be so elected at any special
         meeting does not amount to the required number, the holders of the
         Preferred Stock shall have the right to make such increase in the
         number of directors as shall be necessary to permit the election by
         them of the required number. After the holders of the Preferred Stock
         shall have exercised their right to elect directors in any default
         period and during the continuance of such period, the number of
         directors shall not be increased or decreased except by vote of the
         holders of Preferred Stock as herein provided or pursuant to the rights
         of any equity securities ranking senior to or PARI PASSU with the
         Series A Junior Participating Preferred Stock.

                       (iii) Unless the holders of Preferred Stock shall, during
         an existing default period, have previously exercised their right to
         elect directors, the Board of Directors may order, or any stockholder
         or stockholders owning in the aggregate not less than ten percent (10%)
         of the total number of shares of Preferred Stock outstanding,
         irrespective of series, may request, the calling of a special meeting
         of the holders of Preferred Stock, which meeting shall thereupon be
         called by the President, a Vice-President or the Secretary of the
         Corporation. Notice of such meeting and of any annual meeting at which
         holders of Preferred Stock are entitled to vote pursuant to this
         Paragraph (C)(iii) shall be given to each holder of record of Preferred
         Stock by mailing a copy of such notice to him at his last address as
         the same appears on the books of the Corporation. Such meeting shall be
         called for a time not earlier than twenty (20) days and not later than
         sixty (60) days after such order or request or in default of the
         calling of such meeting within sixty (60) days after such order or
         request, such meeting may be called on similar notice by any
         stockholder or stockholders owning in the aggregate not less than ten
         percent (10%) of the total number of shares of Preferred Stock
         outstanding. Notwithstanding the provisions of this Paragraph (C)(iii),
         no such special meeting shall be called during the period within sixty
         (60) days immediately preceding the date or the first day of the
         period, as the case may be, fixed by the Bylaws of the Corporation for
         the next annual meeting of the stockholders.

                       (iv) In any default period, the holders of Common Stock,
         and other classes of stock of the Corporation if applicable, shall
         continue to be entitled to elect the whole number of directors until
         the holders of Preferred

                                       v


         Stock shall have exercised their right to elect two (2) directors
         voting as a class, after the exercise of which right (x) the directors
         so elected by the holders of Preferred Stock shall continue in office
         until their successors shall have been elected by such holders or until
         the expiration of the default period, whichever happens first, and (y)
         any vacancy in the Board of Directors may (except as provided in
         Paragraph (C)(ii) of this Section 3) be filled by vote of a majority of
         the remaining directors theretofore elected by the holders of the class
         of stock which elected the director whose office shall have become
         vacant. References in this Paragraph (C) to directors elected by the
         holders of a particular class of stock shall include directors elected
         by such directors to fill vacancies as provided in clause (y) of the
         foregoing sentence.

                       (v) Immediately upon the expiration of a default period,
         (x) the right of the holders of Preferred Stock as a class to elect
         directors shall cease, (y) the term of any directors elected by the
         holders of Preferred Stock as a class shall terminate, and (z) the
         number of directors shall be such number as may be provided for in the
         Certificate or Bylaws irrespective of any increase made pursuant to the
         provisions of Paragraph (C)(ii) of this Section 3 (such number being
         subject, however, to change thereafter in any manner provided by law or
         in the Certificate or Bylaws). Any vacancies in the Board of Directors
         effected by the provisions of clauses (y) and (z) in the preceding
         sentence may be filled by a majority of the remaining directors.

                  (D) Except as set forth herein, holders of Series A Junior
Participating Preferred Stock shall have no special voting rights and their
consent shall not be required (except to the extent they are entitled to vote
with holders of Common Stock as set forth herein) for taking any corporate
action.

                  Section 4. CERTAIN RESTRICTIONS.

                  (A) Whenever quarterly dividends or other dividends or
distributions payable on the Series A Junior Participating Preferred Stock as
provided in Section 2 are in arrears, thereafter and until all accrued and
unpaid dividends and distributions, whether or not authorized or declared, on
shares of Series A Junior Participating Preferred Stock outstanding shall have
been paid in full, the Corporation shall not

                                       vi


                       (i) authorize or declare or pay dividends on, make any
         other distributions on, or redeem or purchase or otherwise acquire for
         consideration any shares of stock ranking junior (either as to
         dividends or upon liquidation, dissolution or winding up) to the Series
         A Junior Participating Preferred Stock;

                       (ii) authorize or declare or pay dividends on or make any
         other distributions on any shares of stock ranking on a parity (either
         as to dividends or upon liquidation, dissolution or winding up) with
         the Series A Junior Participating Preferred Stock, except dividends
         paid ratably on the Series A Junior Participating Preferred Stock and
         all such parity stock on which dividends are payable or in arrears in
         proportion to the total amounts to which the holders of all such shares
         are then entitled;

                       (iii) redeem or purchase or otherwise acquire for
         consideration shares of any stock ranking on a parity (either as to
         dividends or upon liquidation, dissolution or winding up) with the
         Series A Junior Participating Preferred Stock, provided that the
         Corporation may at any time redeem, purchase or otherwise acquire
         shares of any such parity stock in exchange for shares of any stock of
         the Corporation ranking junior (either as to dividends or upon
         dissolution, liquidation or winding up) to the Series A Junior
         Participating Preferred Stock; or

                       (iv) purchase or otherwise acquire for consideration any
         shares of Series A Junior Participating Preferred Stock, or any shares
         of stock ranking on a parity with the Series A Junior Participating
         Preferred Stock, except in accordance with a purchase offer made in
         writing or by publication (as determined by the Board of Directors) to
         all holders of such shares upon such terms as the Board of Directors,
         after consideration of the respective annual dividend rates and other
         relative rights and preferences of the respective series and classes,
         shall determine in good faith will result in fair and equitable
         treatment among the respective series or classes.

                  (B) The Corporation shall not permit any subsidiary of the
Corporation to purchase or otherwise acquire for consideration any shares of
stock of the Corporation unless the Corporation could, under Paragraph (A) of
this Section 4, purchase or otherwise acquire such shares at such time and in
such manner.

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                  Section 5. REACQUIRED SHARES. Any shares of Series A Junior
Participating Preferred Stock purchased or otherwise acquired by the Corporation
in any manner whatsoever shall be retired and cancelled promptly after the
acquisition thereof. All such shares shall upon their cancellation become
authorized but unissued shares of Preferred Stock and may be reissued as part of
a new series of Preferred Stock to be created by resolution or resolutions of
the Board of Directors, subject to the conditions and restrictions on issuance
set forth herein.

                  Section 6. LIQUIDATION, DISSOLUTION OR WINDING UP.

                  (A) Upon any liquidation (voluntary or otherwise), dissolution
or winding up of the Corporation, no distribution shall be made to the holders
of shares of stock ranking junior (either as to dividends or upon liquidation,
dissolution or winding up) to the Series A Junior Participating Preferred Stock
unless, prior thereto, the holders of shares of Series A Junior Participating
Preferred Stock shall have received an amount equal to One Hundred Dollars
($100) per share of Series A Participating Preferred Stock, plus an amount equal
to accrued and unpaid dividends and distributions thereon, whether or not
authorized or declared, to the date of such payment (the "Series A Liquidation
Preference"). Following the payment of the full amount of the Series A
Liquidation Preference, no additional distributions shall be made to the holders
of shares of Series A Junior Participating Preferred Stock unless, prior
thereto, the holders of shares of Common Stock shall have received an amount per
share (the "Common Adjustment") equal to the quotient obtained by dividing (i)
the Series A Liquidation Preference by (ii) one hundred (100) (as appropriately
adjusted as set forth in subparagraph (C) below to reflect such events as stock
splits, stock dividends and recapitalizations with respect to the Common Stock)
(such number in clause (ii), the "Adjustment Number"). Following the payment of
the full amount of the Series A Liquidation Preference and the Common Adjustment
in respect of all outstanding shares of Series A Junior Participating Preferred
Stock and Common Stock, respectively, holders of Series A Junior Participating
Preferred Stock and holders of shares of Common Stock shall receive their
ratable and proportionate share of the remaining assets to be distributed in the
ratio of the Adjustment Number to one (l) with respect to such Preferred Stock
and Common Stock, on a per share basis, respectively. The merger or
consolidation of the Corporation, regardless of whether the Corporation is the
surviving entity in such merger or consolidation, shall not be deemed to be the
liquidation, dissolution or winding up of the Corporation.

                                      viii


                  (B) In the event, however, that there are not sufficient
assets available to permit payment in full of the Series A Liquidation
Preference and the liquidation preferences of all other series of preferred
stock, if any, which rank on a parity with the Series A Junior Participating
Preferred Stock, then such remaining assets shall be distributed ratably in the
same proportion as the respective amounts that would be payable on such Series A
Junior Participating Preferred Stock and any such other parity stock if all
amounts payable thereon were paid in full. In the event, however, that there are
not sufficient assets available to permit payment in full of the Common
Adjustment, then such remaining assets shall be distributed ratably to the
holders of Common Stock.

                  (C) In the event the Corporation shall at any time after the
Rights Record Date (i) declare any dividend on Common Stock payable in shares of
Common Stock, (ii) subdivide the outstanding Common Stock, or (iii) combine the
outstanding Common Stock into a smaller number of shares, then in each such case
the Adjustment Number in effect immediately prior to such event shall be
adjusted by multiplying such Adjustment Number by a fraction the numerator of
which is the number of shares of Common Stock outstanding immediately after such
event and the denominator of which is the number of shares of Common Stock that
were outstanding immediately prior to such event.

                  Section 7. CONSOLIDATION, MERGER, ETC. If the Corporation
shall enter into any consolidation, merger, combination or other transaction in
which the shares of Common Stock are exchanged for or changed into other stock
or securities, cash and/or any other property, then in any such case the shares
of Series A Junior Participating Preferred Stock shall at the same time be
similarly exchanged or changed in an amount per share (subject to the provision
for adjustment hereinafter set forth) equal to one hundred (100) times the
aggregate amount of stock, securities, cash and/or any other property (payable
in kind), as the case may be, into which or for which each share of Common Stock
is changed or exchanged. In the event the Corporation shall at any time after
the Rights Record Date (i) declare any dividend on Common Stock payable in
shares of Common Stock, (ii) subdivide the outstanding Common Stock, or (iii)
combine the outstanding Common Stock into a smaller number of shares, then in
each such case the amount set forth in the preceding sentence with respect to
the exchange or change of shares of Series A Junior Participating Preferred
Stock shall be adjusted by multiplying such amount by a fraction the numerator
of which is the number of shares of Common Stock outstanding immediately after
such event and the denominator of which is the

                                      ix


number of shares of Common Stock that were outstanding immediately prior to such
event.

                  Section 8. NO REDEMPTION. The shares of Series A Junior
Participating Preferred Stock shall not be redeemable.

                  Section 9. RANKING.

                  (a) The Series A Junior Participating Preferred Stock shall
rank junior to all other series of the Corporation's Preferred Stock as to the
payment of dividends and the distribution of assets, unless the terms of any
such series shall provide otherwise.

                  (b) The liquidation preference of the outstanding shares of
Series A Junior Participating Preferred Stock will not be added to the
liabilities of the Corporation for the purpose of determining whether under the
Delaware General Corporation Law a distribution may be made to stockholders of
the Corporation whose preferential rights upon dissolution of the Corporation
are junior to those of holders of Series A Junior Participating Preferred Stock.

                  Section 10. AMENDMENT. At any time when any shares of Series A
Junior Participating Preferred Stock are outstanding, neither the Certificate
nor this Certificate of Designations shall be amended in any manner which would
materially alter or change the powers, preferences or special rights of the
Series A Junior Participating Preferred Stock so as to affect them adversely
without the affirmative vote of the holders of a majority or more of the
outstanding shares of Series A Junior Participating Preferred Stock, voting
separately as a class; provided that none of (i) the creation or issuance of (A)
additional shares of Series A Junior Participating Preferred Stock or (B) shares
of any class or series of Preferred Stock ranking junior to or on parity with
the Series A Junior Participating Preferred Stock as to the payment of dividends
and the distribution of assets, (ii) a merger or consolidation in which the
Corporation is the surviving entity and the Series A Junior Participating
Preferred Stock remains outstanding with no material adverse change in its
powers, preferences and special rights, or (iii) a merger or consolidation in
which the Corporation is not the surviving entity and the holders of the Series
A Junior Participating Preferred Stock receive in exchange therefor a
substantially identical security of the surviving entity, shall be considered to
materially adversely alter or change the powers, preferences or special powers
of the Series A Junior Participating Preferred Stock.

                                       x


                  Section 11. FRACTIONAL SHARES. Series A Junior Participating
Preferred Stock may be issued in fractions of a share which shall entitle the
holder, in proportion to such holder's fractional shares, to exercise voting
rights, receive dividends, participate in distributions and to have the benefit
of all other rights of holders of Series A Junior Participating Preferred Stock.

                  Section 12. CERTIFICATE LEGENDS. The Board of Directors may
authorize the issue of some or all of the shares (including fractional
shares) of Series A Junior Participating Preferred Stock without
certificates. If issued in certificated form, each share (including each
fractional share) of Series A Junior Participating Preferred Stock shall bear
substantially the following legend in addition to any legends required to
comply with federal and state securities laws:

                                CLASSES OF STOCK

         THE CORPORATION IS AUTHORIZED TO ISSUE CAPITAL STOCK OF MORE THAN ONE
         CLASS, CONSISTING OF COMMON STOCK AND ONE OR MORE CLASSES OF PREFERRED
         STOCK. THE BOARD OF DIRECTORS IS AUTHORIZED TO DETERMINE THE
         PREFERENCES, LIMITATIONS AND RELATIVE RIGHTS OF ANY CLASS OF PREFERRED
         STOCK BEFORE THE ISSUANCE OF SHARES OF SUCH CLASS OF PREFERRED STOCK.
         THE CORPORATION WILL FURNISH, WITHOUT CHARGE, TO ANY STOCKHOLDER MAKING
         A WRITTEN REQUEST THEREFORE, A COPY OF THE CORPORATION'S CERTIFICATE
         AND A WRITTEN STATEMENT OF THE DESIGNATIONS, RELATIVE RIGHTS,
         PREFERENCES, CONVERSION OR OTHER RIGHTS, VOTING POWERS, RESTRICTIONS,
         LIMITATIONS AS TO THE DIVIDENDS AND OTHER DISTRIBUTIONS, QUALIFICATIONS
         AND TERMS AND CONDITIONS OF REDEMPTION OF THE STOCK OF EACH CLASS WHICH
         THE CORPORATION HAS THE AUTHORITY TO ISSUE AND, IF THE CORPORATION IS
         AUTHORIZED TO ISSUE ANY PREFERRED OR SPECIAL CLASS IN SERIES, (i) THE
         DIFFERENCES IN THE RELATIVE RIGHTS AND PREFERENCES BETWEEN THE SHARES
         OF EACH SERIES TO THE EXTENT SET, AND (ii) THE AUTHORITY OF THE BOARD
         OF DIRECTORS TO

                                       xi


         SET SUCH RIGHTS AND PREFERENCES OF SUBSEQUENT SERIES. REQUESTS FOR SUCH
         WRITTEN STATEMENT MAY BE DIRECTED TO THE SECRETARY OF THE CORPORATION
         AT ITS PRINCIPAL OFFICE.


                                      xii


                  SECOND: The Shares have been classified and designated by the
Board of Directors under authority contained in the Certificate.

                  THIRD: This Certificate of Designations has been approved by
the Board of Directors in the manner and by the vote required by law.

                  FOURTH: The undersigned President and Chief Executive Officer
of the Corporation acknowledges this Certificate of Designations to be the
corporate act of the Corporation and, as to all matters or facts required to be
verified under oath, the undersigned President and Chief Executive Officer of
the Corporation acknowledges that to the best of his knowledge, information and
belief, these matters and facts are true in all material respects and that this
statement is made under the penalties for perjury.

                            [Signature page follows.]


                                      xiii



                  IN WITNESS WHEREOF, the Corporation has caused this
Certificate of Amendment and Restatement of the Certificate of Designations
to be executed under seal in its name and on its behalf by its President on
this 10th day of July, 2001.

                                       VERSICOR INC.


                                       By: /s/ GEORGE F. HORNER III
                                           -------------------------------------
                                           George F. Horner III
                                           President and Chief Executive Officer




                  CERTIFICATE OF THE PRESIDENT OF VERSICOR INC.

                  THE UNDERSIGNED, President of Versicor Inc., who executed
on behalf of the Corporation the Certificate of Amendment and Restatement of
the Certificate of Designations of which this Certificate is made a part,
hereby acknowledges in the name and on behalf of said Corporation the
foregoing Certificate of Amendment and Restatement of the Certificate of
Designations to be the corporate act of said Corporation and hereby certifies
that the matters and facts set forth herein with respect to the authorization
and approval thereof are true in all material respects under the penalties of
perjury.

                                           /s/ GEORGE F. HORNER III
                                           -------------------------------------
                                           George F. Horner III
                                           President and Chief Executive Officer

(SEAL)

                                      xiv