EXHIBIT 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS


We hereby consent to the incorporation by reference in this Registration
Statement on Form S-8 of ArQule, Inc. for its Amended and Restated 1996 Employee
Stock Purchase Plan of our report dated January 11, 2001, except as to Footnote
14, which is as of March 14, 2001 relating to the financial statements which
appear in ArQule's Annual Report on Form 10-K for the year ended December 31,
2000.


                                              /s/ PRICEWATERHOUSECOOPERS LLP




Boston, Massachusetts
August 21, 2001