PROSPECTUS SUPPLEMENT                  FILED PURSUANT TO RULES 424(b)(3) AND (c)
DATED DECEMBER 7, 2001 (TO PROSPECTUS                        FILE NO. 333-49018
DATED NOVEMBER 22, 2000)


                                2,631,375 SHARES


                        ENCHIRA BIOTECHNOLOGY CORPORATION

                                  COMMON STOCK

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This prospectus supplement amends and supplements the prospectus dated November
22, 2000 included in a registration statement that we filed with the SEC using
the "shelf" registration process. It relates to the public offering, which is
not being underwritten, of 2,631,375 shares of our common stock which may be
offered and sold from time to time by the selling stockholders named in the
prospectus.

The "Selling Stockholders" section of the prospectus is hereby amended to
correct the amount of shares registered on behalf of the following two selling
stockholders to the following amounts:

      Oracle Offshore Limited:  39,600 shares outstanding; 11,880 shares
      issuable upon exercise of warrants; and 51,480 total shares.

      Sam Oracle Investments Inc.:  79,200 shares outstanding; 23,760
      shares issuable upon exercise of warrants; and 102,960 total shares.

This does not change the aggregate amount of shares that were registered in the
original prospectus.

This prospectus supplement should be read in conjunction with the prospectus,
and this prospectus supplement is qualified by reference to the prospectus
except to the extent that the information contained herein supersedes the
information contained in the prospectus. Capitalized terms used in this
prospectus supplement and not otherwise defined herein have the meanings
specified in the prospectus.

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Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or determined if this
prospectus is truthful or complete. Any representation to the contrary is a
criminal offense.

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