As filed with the Securities and Exchange Commission on February 12, 2002 Registration No. 333-66304 ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 COR THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Its Charter) DELAWARE 94-3060271 (State or Other Jurisdiction of (I.R.S. Employer Incorporation or Organization) Identification No.) 75 SIDNEY STREET CAMBRIDGE, MASSACHUSETTS 02139 (617) 679-7000 (Address, including zip code, and telephone number, including area code, of principal executive offices) 1991 EQUITY INCENTIVE PLAN 1991 EMPLOYEE STOCK PURCHASE PLAN 1994 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN 1998 NON-OFFICER EQUITY INCENTIVE PLAN (Full Title of the Plans) JOHN B. DOUGLAS III, ESQ. PRESIDENT COR THERAPEUTICS, INC. 75 SIDNEY STREET CAMBRIDGE, MASSACHUSETTS 02139 (Name and Address of Agent For Service) (617) 679-7000 (Telephone Number, Including Area Code, of Agent For Service) ------------------- Copy to: David E. Redlick, Esq. Hale and Dorr LLP 60 State Street Boston, Massachusetts 02109 Telephone: (617) 526-6000 Telecopy: (617) 526-5000 DEREGISTRATION OF COMMON STOCK On July 31, 2001, COR Therapeutics, Inc. ("COR") filed a Registration Statement on Form S-8, Registration No. 333-66304 (the "Registration Statement"), for the sale of 2,250,000 shares of COR Common Stock, $.0001 par value per share (the "Common Stock"), under the COR Therapeutics, Inc. 1991 Equity Incentive Plan, the COR Therapeutics, Inc. 1991 Employee Stock Purchase Plan, the COR Therapeutics, Inc. 1994 Non-Employee Directors' Stock Option Plan and the COR Therapeutics, Inc. 1998 Non-Officer Equity Incentive Plan (collectively, the "Plans"). On February 12, 2002, pursuant to the terms of an Agreement and Plan of Merger, dated as of December 5, 2001 (the "Merger Agreement"), by and among Millennium Pharmaceuticals, Inc. ("Millennium"), PGM Corporation, a wholly owed subsidiary of Millennium, and COR, PGM Corporation merged with and into COR and COR became a wholly owned subsidiary of Millennium. Pursuant to the Merger Agreement, , except for the COR Therapeutics, Inc. 1991 Employee Stock Purchase Plan, Millennium assumed each of the Plans and the obligations of COR under each of the Plans. The COR Therapeutics, Inc. 1991 Employee Stock Purchase Plan was terminated. This Post-Effective Amendment No. 1 to the Registration Statement is being filed to deregister all of the unsold shares of Common Stock formerly issuable under the COR Therapeutics, Inc. 1991 Equity Incentive Plan, constituting 1,000,000 shares, the COR Therapeutics, Inc. 1991 Employee Stock Purchase Plan, constituting 450,000 shares, the COR Therapeutics, Inc. 1994 Non-Employee Directors' Stock Option Plan, constituting 300,000 shares, and the COR Therapeutics, Inc. 1998 Non-Officer Equity Incentive Plan, constituting 500,000 shares. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Post-Effective Amendment No. 1 to Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 12th day of February, 2002. COR THERAPEUTICS, INC. By: /S/ JOHN B. DOUGLAS III ----------------------- John B. Douglas III President and Director Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment has been signed by the following persons in the capacities and on the dates indicated. SIGNATURE TITLE DATE --------- ----- ----- /S/ JOHN B. DOUGLAS III President and Director February 12, 2002 - ------------------------ (Principal Executive Officer) John B. Douglas III /S/ KEVIN P. STARR Treasurer and Director (Principal February 12, 2002 - ----------------------- Financial and Accounting Officer) Kevin P. Starr /S/ MARK J. LEVIN Director February 12, 2002 - ---------------------- Mark J. Levin