<Page> As filed with the Securities and Exchange Commission on April 18, 2002 REGISTRATION NO. - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ----------------------------- MEDICAL STAFFING NETWORK HOLDINGS, INC. (Exact name of registrant as specified in its charter) DELAWARE 7363 65-0865171 (State or other jurisdiction of (Primary Standard Industrial (I.R.S. Employer incorporation or organization) Classification Code Number) Identification No.) 901 YAMATO ROAD, SUITE 110 BOCA RATON, FL 33431 (561) 226-9000 (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) ROBERT J. ADAMSON PRESIDENT AND CHIEF EXECUTIVE OFFICER MEDICAL STAFFING NETWORK HOLDINGS, INC. 901 YAMATO ROAD, SUITE 110 BOCA RATON, FL 33431 (561) 226-9000 (Name, address, including zip code, and telephone number, including area code, of agent for service) ----------------------------- COPIES TO: Steven J. Gartner, Esq. Alejandro E. Camacho, Esq. Willkie Farr & Gallagher Clifford Chance Rogers & Wells LLP 787 Seventh Avenue 200 Park Avenue New York, New York 10019 New York, New York 10166-0153 (212) 728-8000 (212) 878-8000 ----------------------------- APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after this Registration Statement becomes effective. ----------------------------- If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, as amended, check the following box: /_/ If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. /X/ REGISTRATION NO. 333-82438 If this form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. /_/ If this form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. /_/ If delivery of the prospectus is expected to be made pursuant to Rule 434, check the following box. /_/ ----------------------------- CALCULATION OF REGISTRATION FEE ================================================================================ TITLE OF SECURITIES TO BE PROPOSED MAXIMUM AGGREGATE AMOUNT OF REGISTERED OFFERING PRICE (1) REGISTRATION FEE - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- Common Stock, par value $0.01.... $17,968,750 $1,654 ================================================================================ (1) Estimated solely for purposes of determining the registration fee in accordance with Rule 457(o) under the Securities Act of 1933. ----------------------------- <Page> EXPLANATORY NOTE This Registration Statement is being filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended. The contents of the Registration Statement on Form S-1 (File No. 333-82438) filed by Medical Staffing Network Holdings, Inc. with the Securities and Exchange Commission (the "Commission") on February 8, 2002, as amended, which was declared effective by the Commission on April 17, 2002, are incorporated by reference herein. <Page> SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Boca Raton, Florida on this 18th day of April, 2002. MEDICAL STAFFING NETWORK HOLDINGS, INC. By: /s/ Robert J. Adamson ------------------------------------------------ Robert J. Adamson President, Chief Executive Officer And Director Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated. <Table> <Caption> SIGNATURE TITLE DATE - --------- ----- ---- /s/ Robert J. Adamson President, Chief Executive Officer and April 18, 2002 - ---------------------------------------- Director (Principal Executive Officer) Robert J. Adamson * Chief Financial Officer (Principal Financial April 18, 2002 - ---------------------------------------- Officer and Principal Accounting Officer) Kevin S. Little * Director April 18, 2002 - ---------------------------------------- Joel Ackerman * Director April 18, 2002 - ---------------------------------------- David J. Wenstrup * Director April 18, 2002 - ---------------------------------------- Scott F. Hilinski *By: /s/ Robert J. Adamson ------------------------------------ Robert J. Adamson ATTORNEY-IN-FACT </Table> II-1 <Page> Exhibit Index EXHIBIT NO. DESCRIPTION - ----------- ----------- 5.1 Opinion of Willkie Farr & Gallagher. 23.1 Consent of Ernst & Young. 23.2 Consent of Willkie Farr & Gallagher (included in the opinion referred to in 5.1 above). 24.1* Power of Attorney - ----------- *Incorporated by reference from the Registration Statement on Form S-1, as amended (File No. 333-82438). II-2