<Page> SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): JUNE 27, 2002 ------------- EXACT SCIENCES CORPORATION -------------------------- (Exact Name of Registrant as Specified in Its Charter) DELAWARE ------------ (State or Other Jurisdiction of Incorporation) 000-32179 02-0478229 ---------------------- ------------------------------- (Commission File Number) (IRS Employer Identification No.) 63 GREAT ROAD, MAYNARD, MASSACHUSETTS 01754 -------------------------------------- -------- (Address of Principal Executive Offices) (Zip Code) Registrant's telephone number, including area code: (978) 897-2800 -------------- <Page> ITEM 5. OTHER EVENTS. On June 27, 2002, EXACT Sciences Corporation entered into a strategic alliance and related warrant with Laboratory Corporation of America - -Registered Trademark- Holdings as described in the press release filed as Exhibit 99.1 to this Current Report on Form 8-K, such press release being incorporated herein by reference. ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS. (c) Exhibits 99.1 Press Release dated June 27, 2002. 2 <Page> SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. EXACT Sciences Corporation June 27, 2002 By: /s/ John A. McCarthy, Jr. ------------------------------- John A. McCarthy, Jr. Executive Vice President, Chief Operating Officer, Chief Financial Officer and Treasurer 3 <Page> EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION 99.1 Press Release dated June 27, 2002. 4