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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                    FORM 8-K
     


                                 CURRENT REPORT
     


                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                        Date of Report (Date of earliest
                                event reported):
                                  May 22, 1996

     

                                 XYTRONYX, INC.
                         ------------------------------
             (Exact name of registrant as specified in its charter)
     


                                    Delaware
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                  (State or other jurisdiction of incorporation
     

              0-14838                                  36-3258753          
            ------------                            -----------------
        (Commissioner File Number)       (IRS Employer Identification Number)
     
     


                             6555 Nancy Ridge Drive
                                    Suite 200
                          San Diego, California  92121
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               (Address of principal executive offices) (Zip Code)
     
     

Registrant's telephone number, including area code:  (619) 550-3900
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Item 5.   Other Events.

     The News Release dated May 22, 1996 announcing European distribution
agreement for the Periodontal Tissue Monitor kit, filed as Exhibit 99.52 hereto,
is hereby incorporated into this Report by reference.

     


Item 7.   Financial Statements, Pro Forma Financial Information and Exhibits.

     (c)  EXHIBITS. The following exhibit accompanies this Report:

     Exhibit
     Number                   Exhibit Description
     -------                  -------------------

     99.52     News Release dated May 22, 1996 announcing  European distribution
               agreement for the Periodontal Tissue Monitor kit.











                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                              XYTRONYX, INC.


                              By:   /s/ DALE SANDER              
                                   ------------------------------
                                        Dale Sander
                                        Chief Financial Officer

Date:  May 24, 1996


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                                INDEX TO EXHIBITS



Exhibit                                                          Sequentially
Number                       Description of Exhibit              Numbered Page
- -------                      ----------------------              -------------

  99.52     News Release dated May 22, 1996 announcing  European 
            distribution agreement for the Periodontal Tissue 
            Monitor kit.


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