_______________________________________________________________________________
                                EXHIBIT 10.40
BANK OF AMERICA                                 BUSINESS LOAN AGREEMENT
NATIONAL TRUST AND SAVINGS ASSOCIATION
_______________________________________________________________________________

This Agreement dated as of September 24, 1996, is between Bank of America 
National Trust and Savings Association (the "Bank") and Arris Pharmaceutical 
Corporation (the "Borrower").

1.   LINE OF CREDIT AMOUNT AND TERMS

1.1  LINE OF CREDIT AMOUNT.

(a)  During the availability period described below, the Bank will provide a
     line of credit to the Borrower.  The amount of the line of credit (the
     "Commitment") is the lesser of:

     (i)  Twelve Million Dollars ($12,000,000) or

     (ii) the sum of the following:

          (A)  the amount of Bank of America time deposits pledged to the Bank;
               plus

          (B)  the loan value of the marketable securities pledged to the Bank.
               The loan value of a marketable security will be a percentage of 
               its fair market value.  Except for the types of securities listed
               below, the fair market value will be determined by the Bank from 
               time to time in its sole discretion.  The percentage applied to 
               a particular marketable security will be set by the Bank at the 
               time it is pledged to the Bank.  The percentage can be changed by
               the Bank at any time for reasonable cause.  The Bank's records of
               the applicable percentage will be controlling.  It is provided, 
               however, that notwithstanding any of the foregoing, the Bank and 
               the Borrower agree that the loan value of marketable securities 
               consisting of (1) U.S. treasury bills will be 90%, (2) U.S. 
               treasury notes or bonds or other obligations issued or guaranteed
               by the federal government and with maturities longer than one 
               year will be 80%, and (3) U.S. corporate or municipal bonds rated
               at least AA by Standard & Poor's Ratings Group or at least Aa by 
               Moody's Investors Service, Inc. will be 75%.
              
     If at any time the total amount of principal outstanding under the line of
     credit exceeds this limit, the Borrower will immediately either increase
     the loan value of marketable securities or other acceptable collateral
     pledged to the Bank, or reduce the total amount outstanding in order to
     comply with this limit.  If any of the pledged assets are margin stock, the
     Borrower will provide the Bank a Form U-1 Purpose Statement, and the Bank
     and the Borrower will comply with the restrictions imposed by Regulation U
     of the Federal Reserve, which may require a reduction in the loan value of
     the margin stock pledged to the Bank.

     The Bank is prohibited from accepting as collateral certain Ineligible
     Securities while they are being underwritten or privately placed by BA
     Securities, Inc.  The Bank shall comply with these restrictions.  BA 
     Securities, Inc. is a wholly-owned subsidiary of BankAmerica Corporation, 
     and is a registered broker-dealer which is permitted to underwrite and deal
     in certain Ineligible Securities.  "Ineligible Securities" means securities
     which may not be underwritten or dealt in by member banks of the Federal 
     Reserve System under Section 16 of the Banking Act of 1933 (12 U.S.C. 
     Section 24, Seventh), as amended.

(b)  This is a revolving line of credit with a term repayment option.  During
     the availability period, the Borrower may repay principal amounts and 
     reborrow them.


                                      -1-


(c)  The Borrower agrees not to permit the outstanding principal balance of the
     line of credit to exceed the Commitment.

1.2  AVAILABILITY PERIOD.  The line of credit is available between the date of
this Agreement and December 31, 1997 (the "Expiration Date") unless the Borrower
is in default.

1.3  INTEREST RATE.

(a)  Unless the Borrower elects an optional interest rate as described below, 
     the interest rate is (i) the Bank's Reference Rate minus 1.50 percentage
     points with respect to that portion of the outstanding principal balance 
     of the line of credit that is less than or equal to the amount of Bank of 
     America time deposits pledged to the Bank and (ii) the Bank's Reference 
     Rate minus 1.0 percentage point with respect to that portion of the 
     outstanding principal balance of the line of credit that exceeds the amount
     of Bank of America time deposits pledged to the Bank.

(b)  The Reference Rate is the rate of interest publicly announced from time to
     time by the Bank in San Francisco, California, as its Reference Rate.  The
     Reference Rate is set by the Bank based on various factors, including the 
     Bank's costs and desired return, general economic conditions and other 
     factors, and is used as a reference point for pricing some loans.  The Bank
     may price loans to its customers at, above, or below the Reference Rate. 
     Any change in the Reference Rate shall take effect at the opening of 
     business on the day specified in the public announcement of a change in the
     Bank's Reference Rate.

1.4  REPAYMENT TERMS.

(a)  The Borrower will pay interest on October 1, 1996, and then monthly
     thereafter until payment in full of any principal outstanding under this 
     line of credit.

(b)  The Borrower will repay the principal amount outstanding on the Expiration
     Date in 20 successive equal quarterly installments starting April 1, 1998. 
     On December 31, 2002, the Borrower will repay the remaining principal 
     balance plus any interest then due.

(c)  The Borrower may prepay the loan in full or in part at any time.  The
     prepayment will be applied to the most remote installment of principal due
     under this Agreement.

1.5  OPTIONAL INTEREST RATES.  Instead of the interest rate based on the Bank's
Reference Rate, the Borrower may elect to have all or portions of the line of
credit (during the availability period and during the term repayment period)
bear interest at the rate(s) described below during an interest period agreed to
by the Bank and the Borrower.  Each interest rate is a rate per year.  Interest
will be paid on the last day of each interest period, and, if the interest
period is longer than three months, then on the last day each quarter during the
interest period.  At the end of any interest period, the interest rate will
revert to the rate based on the Reference Rate, unless the Borrower has
designated another optional interest rate for the portion.

1.6  LIBOR RATE.  The Borrower may elect to have all or portions of the
principal balance bear interest at the LIBOR Rate plus the applicable spread. 
The applicable spread will be (1) 0.495 percentage point with respect to that
portion of the outstanding LIBOR Rate portions that, when added to the
outstanding principal balance (if any) bearing interest at the Bank's Reference
Rate minus 1.5 percentage points, results in a sum less than or equal to the
amount of Bank of America time deposits pledged to the Bank and (2) 0.995
percentage point with respect to the remaining portion of the outstanding LIBOR
Rate portions.

Designation of a LIBOR Rate portion is subject to the following requirements:

(a)  The interest period during which the LIBOR Rate will be in effect will be
     one, two, three, or six months.  The first day of the interest period must
     be a day other than a Saturday or a Sunday on which the Bank is open for 
     business in California, New York and London and dealing in offshore dollars
     (a "LIBOR 


                                      -2-


     Banking Day").  The last day of the interest period and the actual number 
     of days during the interest period will be determined by the Bank using the
     practices of the London inter-bank market.

(b)  Each LIBOR Rate portion will be for an amount not less than Five Hundred
     Thousand Dollars ($500,000).

(c)  The "LIBOR Rate" means the interest rate determined by the following
     formula, rounded upward to the nearest 1/100 of one percent.  (All amounts
     in the calculation will be determined by the Bank as of the first day of 
     the interest period.)

                   LIBOR Rate  =  London Inter-Bank Offered Rate
                                  ------------------------------
                                    (1.00 - Reserve Percentage)

     Where,

     (i)  "London Inter-Bank Offered Rate" means the interest rate (rounded
          upward to the nearest  1/16th of one percent) at which the Bank's 
          London Branch, London, Great Britain, would offer U.S. dollar deposits
          for the applicable interest period to other major banks in the London 
          inter-bank market at approximately 11:00 a.m. London time two (2) 
          London Banking Days before the commencement of the interest period.  
          A "London Banking Day" is a day on which the Bank's London Branch is 
          open for business and dealing in offshore dollars.

     (ii) "Reserve Percentage" means the total of the maximum reserve 
           percentages for determining the reserves to be maintained by member 
           banks of the Federal Reserve System for Eurocurrency Liabilities, as 
           defined in Federal Reserve Board Regulation D, rounded upward to the 
           nearest 1/100 of one percent.  The percentage will be expressed as a 
           decimal, and will include, but not be limited to, marginal, 
           emergency, supplemental, special, and other reserve percentages.

(d)  The Borrower shall irrevocably request a LIBOR Rate portion no later than
     12:00 noon San Francisco time on the LIBOR Banking Day preceding the day on
     which the London Inter-Bank Offered Rate will be set, as specified above.

(e)  The Borrower may not elect a LIBOR Rate with respect to any principal
     amount which is scheduled to be repaid before the last day of the 
     applicable interest period.

(f)  Any portion of the principal balance already bearing interest at the LIBOR
     Rate will not be converted to a  different rate during its interest period.

(g)  Each prepayment of a LIBOR Rate portion, whether voluntary, by reason of
     acceleration or otherwise, will be accompanied by the amount of accrued 
     interest on the amount prepaid and a prepayment fee as described below.  
     A "prepayment" is a payment of an amount on a date earlier than the 
     scheduled payment date for such amount as required by this Agreement.  
     The prepayment fee shall be equal to the amount (if any) by which:

     (i)  the additional interest which would have been payable during the
          interest period on the amount prepaid had it not been prepaid, exceeds

     (ii) the interest which would have been recoverable by the Bank by placing
          the amount prepaid on deposit in the domestic certificate of deposit
          market, the eurodollar deposit market, or other appropriate money 
          market selected by the Bank, for a period starting on the date on 
          which it was prepaid and ending on the last day of the interest period
          for such portion (or the scheduled payment date for the amount 
          prepaid, if earlier).


                                      -3-


(h)  The Bank will have no obligation to accept an election for a LIBOR Rate
     portion if Dollar deposits in the principal amount, and for periods equal 
     to the interest period, of a LIBOR Rate portion are not available in the 
     London inter-bank market.

2.   EXPENSES

(a)  The Borrower agrees to immediately repay the Bank for expenses that 
     include, but not limited to, filing, recording and search fees, appraisal 
     fees and documentation fees related to this Agreement.

(b)  The Borrower agrees to reimburse the Bank for any expenses it incurs in the
     preparation of this Agreement and any agreement or instrument required by 
     this Agreement up to a maximum of Five Thousand Dollars ($5,000).  Expenses
     include, but are not limited to, reasonable attorneys' fees, including any 
     allocated costs of the Bank's in-house counsel.

3.   COLLATERAL

3.1  PERSONAL PROPERTY.  The Borrower's obligations to the Bank under this 
Agreement will be secured by personal property the Borrower now owns or will 
own in the future as listed below.  The collateral is further defined in 
security agreement(s) executed by the Borrower.  In addition, all personal 
property collateral securing this Agreement shall also secure all other 
present and future obligations of the Borrower to the Bank (excluding any 
consumer credit covered by the federal Truth in Lending law, unless the 
Borrower has otherwise agreed in writing).  All personal property collateral 
securing any other present or future obligations of the Borrower to the Bank 
shall also secure this Agreement.

(a)  Stock and other securities.

(b)  Bank of America time deposits.

4.   DISBURSEMENTS, PAYMENTS AND COSTS

4.1  REQUESTS FOR CREDIT.  Each request for an extension of credit will be made
in writing in a manner reasonably acceptable to the Bank, or by another means
acceptable to the Bank.

4.2  DISBURSEMENTS AND PAYMENTS.  Each disbursement by the Bank and each payment
by the Borrower will be:

(a)  made at the Bank's branch (or other location) selected by the Bank from
     time to time;

(b)  made for the account of the Bank's branch selected by the Bank from time to
     time;

(c)  made in immediately available funds consisting of U.S. dollars;

(d)  evidenced by records kept by the Bank.  In addition, the Bank may, at its
     discretion, require the Borrower to sign one or more promissory notes.

4.3  TELEPHONE AND TELEFAX AUTHORIZATION.

(a)  The Bank may honor telephone or telefax instructions for advances or
     repayments or for the designation of optional interest rates given by any 
     one of the individuals authorized to sign loan agreements on behalf of the 
     Borrower, or any other individual designated by any one of such authorized 
     signers.

(b)  Advances will be deposited in and repayments will be withdrawn from the
     Borrower's account number 14998-04747, or such other of the Borrower's 
     accounts with the Bank as designated in writing by the Borrower.


                                      -4-


(c)  The Borrower indemnifies and excuses the Bank (including its officers,
     employees, and agents) from all liability, loss, and costs in connection 
     with any act resulting from telephone or telefax instructions it reasonably
     believes are made by any individual authorized by the Borrower to give such
     instructions.  This indemnity and excuse will survive this Agreement.

4.4  DIRECT DEBIT (PRE-BILLING).

(a)  The Borrower agrees that the Bank will debit the Borrower's deposit account
     number 14998-04747 (the "Designated Account") on the date each payment of
     principal and interest and any fees from the Borrower becomes due (the "Due
     Date").  If the Due Date is not a banking day, the Designated Account will 
     be debited on the next banking day.

(b)  Approximately 10 days prior to each Due Date, the Bank will mail to the
     Borrower a statement of the amounts that will be due on that Due Date (the
     "Billed Amount").  The calculation will be made on the assumption that no 
     new extensions of credit or payments will be made between the date of the 
     billing statement and the Due Date, and that there will be no changes in 
     the applicable interest rate.

(c)  The Bank will debit the Designated Account for the Billed Amount,
     regardless of the actual amount due on that date (the "Accrued Amount").

     If the Billed Amount debited to the Designated Account differs from the
     Accrued Amount, the discrepancy will be treated as follows:

     (i)  If the Billed Amount is less than the Accrued Amount, the Billed
          Amount for the following Due Date will be increased by the amount of 
          the discrepancy.  The Borrower will not be in default by reason of 
          any such discrepancy.
    
     (ii) If the Billed Amount is more than the Accrued Amount, the Billed
          Amount for the following Due Date will be decreased by the amount of 
          the discrepancy.

     Regardless of any such discrepancy, interest will continue to accrue based
     on the actual amount of principal outstanding without compounding.  The
     Bank will not pay the Borrower interest on any overpayment.

(d)  The Borrower will maintain sufficient funds in the Designated Account to
     cover each debit.  If there are insufficient funds in the Designated 
     Account on the date the Bank enters any debit authorized by this Agreement,
     the debit will be reversed.

4.5  BANKING DAYS.  Unless otherwise provided in this Agreement, a banking day
is a day other than a Saturday or a Sunday on which the Bank is open for
business in California. All payments and disbursements which would be due on a
day which is not a banking day will be due on the next banking day.  All
payments received on a day which is not a banking day will be applied to the
credit on the next banking day.

4.6  TAXES.  If any payments to the Bank under this Agreement are made from
outside the United States, the Borrower will not deduct any foreign taxes from
any payments it makes to the Bank.  If any such taxes are imposed on any
payments made by the Borrower (including payments under this paragraph), the
Borrower will pay the taxes and will also pay to the Bank, at the time interest
is paid, any additional amount which the Bank specifies as necessary to preserve
the after-tax yield the Bank would have received if such taxes had not been
imposed. The Borrower will confirm that it has paid the taxes by giving the Bank
official tax receipts (or notarized copies) within 30 days after the due date.

4.7 ADDITIONAL COSTS.


                                      -5-


(a)  The Borrower will pay the Bank, on demand, for the Bank's costs or losses 
     arising from any statute or regulation, or any request or requirement of
     a regulatory agency which is applicable to all national banks or a class 
     of all national banks.  The costs and losses will be allocated to the loan 
     in a manner determined by the Bank, using any reasonable method.  The costs
     include the following:

     (i)  any reserve or deposit requirements; and

     (ii) any capital requirements relating to the Bank's assets and commitments
          for credit.

(b)  The Borrower's obligations under this subparagraph (a) of this paragraph 
     shall be limited to the Bank's costs and losses arising on or after the 
     date which is ninety (90) days after the date the Bank sends written notice
     to the Borrower confirming the Borrower's obligations under this paragraph 
     and describing in reasonably sufficient detail such costs and losses.

4.8  INTEREST CALCULATION.  Except as otherwise stated in this Agreement, all
interest and fees, if any, will be computed on the basis of a 360-day year and
the actual number of days elapsed.  This results in more interest or a higher
fee than if a 365-day year is used.

4.9  INTEREST ON LATE PAYMENTS.  At the Bank's sole option in each instance, any
amount not paid when due under this Agreement (including interest) shall bear
interest from the due date at the Bank's Reference Rate.  This may result in
compounding of interest.

4.10 DEFAULT RATE.  Upon the occurrence and during the continuation of any
default under this Agreement, advances under this Agreement will at the option
of the Bank bear interest at a rate per annum which is 1.0 percentage point
higher than the rate of interest otherwise provided under this Agreement.  This
will not constitute a waiver of any default.

5.   CONDITIONS

The Bank must receive the following items, in form and content acceptable to the
Bank, before it is required to extend any credit to the Borrower under this
Agreement:

5.1  AUTHORIZATIONS.  Evidence that the execution, delivery and performance by
the Borrower of this Agreement and any instrument or agreement required under
this Agreement have been duly authorized.

5.2  GOVERNING DOCUMENTS.  A copy of the Borrower's filed articles of
incorporation and any amendments thereto.

5.3  SECURITY AGREEMENTS.  Signed original security agreements, assignments and
financing statements (together with collateral in which the Bank requires a
possessory security interest), which the Bank requires.

5.4  EVIDENCE OF PRIORITY.  Evidence that security interests and liens in favor
of the Bank are valid, enforceable, and prior to all others' rights and
interests, except those the Bank consents to in writing.  This evidence must
include, without limitation, (i) a copy of a duly signed and filed financing
statement change (Form UCC-2) from Silicon Valley Bank ("SVB") with respect to
SVB's financing statement file no. 9519460184 pursuant to which SVB releases
from the collateral described in said financing statement any and all collateral
consisting of documents, cash, deposit accounts, securities accounts, investment
accounts, securities, certificates of deposit, instruments, chattel paper,
general intangibles and all other investments or property of any sort now or
hereafter owned by the Borrower AND maintained or administered by Bank of
America National Trust and Savings Association in the name of the Borrower or
for the benefit of the Borrower, and all proceeds thereof (the "BofA
Collateral") and (ii) a copy of duly signed and filed financing statement
changes (Form UCC-2) from Hambrecht & Quist Guaranty Finance, L. P. ("H&Q") with
respect to H&Q's financing statement file no. 94059807 and financing statement
file no. 9517760687 pursuant to which H&Q releases from the collateral described
in said financing statements any and all collateral consisting of the BofA
Collateral.


                                      -6-


5.5  OTHER ITEMS.  Any other items that the Bank reasonably requires.

6.   REPRESENTATIONS AND WARRANTIES

When the Borrower signs this Agreement, and until the Bank is repaid in full,
the Borrower makes the following representations and warranties.  Each request
for an extension of credit constitutes a renewed representation.

6.1  ORGANIZATION OF BORROWER.  The Borrower is a corporation duly formed and
existing under the laws of the state where organized.

6.2  AUTHORIZATION.  This Agreement, and any instrument or agreement required
hereunder, are within the Borrower's powers, have been duly authorized, and do
not conflict with any of its organizational papers.

6.3  ENFORCEABLE AGREEMENT.  This Agreement is a legal, valid and binding
agreement of the Borrower, enforceable against the Borrower in accordance with
its terms, and any instrument or agreement required hereunder, when executed and
delivered, will be similarly legal, valid, binding and enforceable.

6.4  GOOD STANDING.  In each state in which the Borrower does business, it is
properly licensed, in good standing, and, where required, in compliance with
fictitious name statutes.

6.5  NO CONFLICTS.  This Agreement does not conflict with any law, agreement, or
obligation by which the Borrower is bound.

6.6  FINANCIAL INFORMATION.  All financial and other information that has been
or will be supplied to the Bank is:

(a)  sufficiently complete to give the Bank accurate knowledge of the Borrower's
     financial condition.

(b)  in form and content required by the Bank.

(c)  in compliance with all government regulations that apply.

6.7  LAWSUITS.  There is no lawsuit, tax claim or other dispute pending or
threatened against the Borrower, which, if lost, would impair the Borrower's
financial condition or ability to repay the loan, except as have been disclosed
in writing to the Bank.

6.8  PERMITS, FRANCHISES.  The Borrower possesses all permits, memberships,
franchises, contracts and licenses required and all trademark rights, trade name
rights, patent rights and fictitious name rights necessary to enable it to
conduct the business in which it is now engaged.

6.9  COLLATERAL.  All collateral required in this Agreement is owned by the
grantor of the security interest free of any title defects or any liens or
interests of others.

6.10 OTHER OBLIGATIONS.  The Borrower is not in default on any obligation for
borrowed money, any purchase money obligation or any other material lease,
commitment, contract, instrument or obligation.

6.11 INCOME TAX RETURNS.  The Borrower has no knowledge of any pending
assessments or adjustments of its income tax for any year.

6.12 NO EVENT OF DEFAULT.  There is no event which is, or with notice or lapse
of time or both would be, a default under this Agreement.

6.13 LOCATION OF BORROWER.  The Borrower's place of business (or, if the
Borrower has more than one place of business, its chief executive office) is
located at the address listed under the Borrower's signature on this Agreement.


                                      -7-


7.   COVENANTS

The Borrower agrees, so long as credit is available under this Agreement and
until the Bank is repaid in full:

7.1  USE OF PROCEEDS.  To use the proceeds of the credit only for working
capital, capital expenditures and general corporate purposes.

7.2  USE OF PROCEEDS - INELIGIBLE SECURITIES.  Not to use, directly or
indirectly, any portion of the proceeds of the credit (including any letters of
credit) for any of the following purposes:

(a)  knowingly to purchase Ineligible Securities from BA Securities, Inc. (the
     "Arranger") during any period in which the Arranger makes a market in such
     Ineligible Securities; or 

(b)  knowingly to purchase during the underwriting or placement period 
     Ineligible Securities being underwritten or privately placed by the 
     Arranger.

7.3  FINANCIAL INFORMATION.  To provide the following financial information and
statements and such additional information as requested by the Bank from time to
time:

(a)  Within 120 days of the Borrower's fiscal year end, the Borrower's annual
     financial statements.  These financial statements must be audited (with an
     unqualified opinion) by Ernst & Young or by another Certified Public 
     Accountant ("CPA") acceptable to the Bank.

(b)  Copies of the Borrower's Form 10-K Annual Report, within 120 days of the
     Borrower's fiscal year end.

(c)  Copies of the Borrower's Form 10-Q Quarterly Report, within 60 days of the
     period's end.

(d)  Copies of the Borrower's Form 8-K Current Report within 30 days after the
     date of filing with the Securities and Exchange Commission.

7.4  NOTICES TO BANK.  To promptly notify the Bank in writing of:

(a)  any lawsuit over One Million Dollars ($1,000,000) against the Borrower.

(b)  any substantial dispute between the Borrower and any government authority.

(c)  any failure to comply with this Agreement.

(d)  any material adverse change in the Borrower's financial condition or
     ability to repay the loan (any such change hereinafter referred to as a
     "Material Adverse Change).

(e)  any change in the Borrower's name, legal structure, place of business, or
     chief executive office if the Borrower has more than one place of business.

7.5  BOOKS AND RECORDS.  To maintain adequate books and records.

7.6  COMPLIANCE WITH LAWS.  To comply with the laws (including any fictitious
name statute), regulations, and orders of any government body with authority
over the Borrower's business with which the failure to comply would cause a
Material Adverse Change.

7.7  PRESERVATION OF RIGHTS.  To maintain and preserve all rights, privileges,
and franchises which the Borrower now has and which the failure to maintain or
preserve would cause a Material Adverse Change.


                                      -8-


7.8  PERFECTION OF LIENS.  To help the Bank perfect and protect its security
interests and liens, and reimburse it for related necessary costs it incurs to
protect its security interests and liens.

7.9  INSURANCE.  To maintain insurance as is usual for the business it is in.

7.10 ADDITIONAL NEGATIVE COVENANTS.  Not to, without the Bank's written consent
(which consent shall not be unreasonably withheld):

(a)  engage in any business activities material in scope and substantially
     different from the Borrower's present business, which is health care.

(b)  liquidate or dissolve the Borrower's business.

8.   DEFAULT

If any of the following events occur, the Bank may do one or more of the
following: declare the Borrower in default, stop making any additional credit
available to the Borrower, and require the Borrower to repay its entire debt
immediately and without prior notice.  If an event of default occurs under the
paragraph entitled "Bankruptcy," below, then the entire debt outstanding under
this Agreement will automatically be due immediately or, with respect to any
bankruptcy petition filed against the Borrower, immediately upon the expiration
of the cure period without dismissal of the petition.

8.1  FAILURE TO PAY.  The Borrower fails to make a payment under this Agreement
within 15 days after the date when due.

8.2  LIEN PRIORITY.  The Bank fails to have an enforceable first lien (except
for any prior liens to which the Bank has consented in writing) on or security
interest in any property given as security for this loan.

8.3  FALSE INFORMATION.  The Borrower has given the Bank false or misleading
information or representations.

8.4  BANKRUPTCY.  The Borrower files a bankruptcy petition, a bankruptcy
petition is filed against the Borrower, or the Borrower makes a general
assignment for the benefit of creditors. The default will be deemed cured if any
bankruptcy petition filed against the Borrower is dismissed within a period of
45 days after the filing; provided, however, that the Bank will not be obligated
to extend any additional credit to the Borrower during that period.

8.5  RECEIVERS.  A receiver or similar official is appointed for the Borrower's
business, or the business is terminated.

8.6  LAWSUITS.  Any lawsuit or lawsuits are filed on behalf of one or more trade
creditors against the Borrower in an aggregate amount of Five Million Dollars
($5,000,000) or more in excess of any insurance coverage, and such lawsuit or
lawsuits are not dismissed within 30 days after filing; provided, however, that
the Bank will not be obligated to extend any additional credit to the Borrower
during that period.

8.7  JUDGMENTS.  Any judgments or arbitration awards are entered against the
Borrower, or the Borrower enters into any settlement agreements with respect to
any litigation or arbitration, in an aggregate amount of Five Million Dollars
($5,000,000) or more in excess of any insurance coverage, and such judgments or
arbitration awards remain unstayed, unvacated, undischarged or unsatisfied for
45 days after entry; provided, however, that the Bank will not be obligated to
extend any additional credit to the Borrower during that period.

8.8  GOVERNMENT ACTION.  Any government authority takes final, non-appealable
action that results in a Material Adverse Change.

8.9  MATERIAL ADVERSE CHANGE.  A Material Adverse Change occurs.


                                      -9-


8.10 DEFAULT UNDER RELATED DOCUMENTS.  Any guaranty, subordination agreement,
security agreement, deed of trust, or other document required by this Agreement
is no longer in effect,  or any such document is violated, and, if there is an
applicable grace or cure period, the violation continues beyond such grace or
cure period.

8.11 OTHER BANK AGREEMENTS.  The Borrower fails to meet the material conditions
of, or fails to perform any material obligation under any other agreement the
Borrower has with the Bank or any affiliate of the Bank.  If, in the Bank's
opinion, the breach is capable of being remedied, the breach will not be
considered an event of default under this Agreement for a period of 30 days
after the date on which the Bank gives written notice of the breach to the
Borrower; provided, however, that the Bank will not be obligated to extend any
additional credit to the Borrower during that period.

8.12 OTHER BREACH UNDER AGREEMENT.  The Borrower fails to meet the conditions
of, or fails to perform any obligation under, any term of this Agreement not
specifically referred to in this Article.  If, in the Bank's opinion, the breach
is capable of being remedied, the breach will not be considered an event of
default under this Agreement for a period of 30 days after the date on which the
Bank gives written notice of the breach to the Borrower; provided, however, that
the Bank will not be obligated to extend any additional credit to the Borrower
during that period.

9.   ENFORCING THIS AGREEMENT; MISCELLANEOUS

9.1  GAAP.  Except as otherwise stated in this Agreement, all financial
information provided to the Bank and all financial covenants will be made under
generally accepted accounting principles, consistently applied.

9.2  CALIFORNIA LAW.  This Agreement is governed by California law.

9.3  SUCCESSORS AND ASSIGNS.  This Agreement is binding on the Borrower's and
the Bank's successors and assignees.  The Borrower agrees that it may not assign
this Agreement without the Bank's prior consent.  The Bank may sell
participations in or, with the prior consent of the Borrower, (which consent
shall not be unreasonably withheld) assign this loan, and may exchange financial
information about the Borrower with actual or potential participants or
assignees.  If a participation is sold or the loan is assigned, the purchaser
will have the right of set-off against the Borrower.

9.4  ARBITRATION.

(a)  This paragraph concerns the resolution of any controversies or claims
     between the Borrower and the Bank, including but not limited to those that 
     arise from:
    
     (i)  This Agreement (including any renewals, extensions or modifications of
          this Agreement);

     (ii) Any document, agreement or procedure related to or delivered in
          connection with this Agreement;

     (iii)Any violation of this Agreement; or

     (iv) Any claims for damages resulting from any business conducted between
          the Borrower and the Bank, including claims for injury to persons, 
          property or business interests (torts).

(b)  At the request of the Borrower or the Bank, any such controversies or
     claims will be settled by arbitration in accordance with the United States 
     Arbitration Act.  The United States Arbitration Act will apply even though 
     this Agreement provides that it is governed by California law.

(c)  Arbitration proceedings will be administered by the American Arbitration
     Association and will be subject to its commercial rules of arbitration.


                                      -10-


(d)  For purposes of the application of the statute of limitations, the filing
     of an arbitration pursuant to this paragraph is the equivalent of the 
     filing of a lawsuit, and any claim or controversy which may be arbitrated 
     under this paragraph is subject to any applicable statute of limitations. 
     The arbitrators will have the authority to decide whether any such claim or
     controversy is barred by the statute of limitations and, if so, to dismiss 
     the arbitration on that basis.

(e)  If there is a dispute as to whether an issue is arbitrable, the arbitrators
     will have the authority to resolve any such dispute.

(f)  The decision that results from an arbitration proceeding may be submitted
     to any authorized court of law to be confirmed and enforced.

(g)  The procedure described above will not apply if the controversy or claim,
     at the time of the proposed submission to arbitration, arises from or 
     relates to an obligation to the Bank secured by real property located in 
     California.  In this case, both the Borrower and the Bank must consent to 
     submission of the claim or controversy to arbitration.  If both parties do
     not consent to arbitration, the controversy or claim will be settled as 
     follows:
    
     (i)  The Borrower and the Bank will designate a referee (or a panel of
          referees) selected under the auspices of the American Arbitration
          Association in the same manner as arbitrators are selected in 
          Association-sponsored proceedings;
    
     (ii) The designated referee (or the panel of referees) will be appointed by
          a court as provided in California Code of Civil Procedure Section 638 
          and the following related sections;

     (iii)The referee (or the presiding referee of the panel) will be an
          active attorney or a retired judge; and
    
     (iv) The award that results from the decision of the referee (or the panel)
          will be entered as a judgment in the court that appointed the referee,
          in accordance with the provisions of California Code of Civil 
          Procedure Sections 644 and 645.

(h)  This provision does not limit the right of the Borrower or the Bank to:

     (i)  exercise self-help remedies such as setoff;

     (ii) foreclose against or sell any real or personal property collateral; or

     (iii)act in a court of law, before, during or after the arbitration
          proceeding to obtain:
         
          (A)  an interim remedy; and/or

          (B)  additional or supplementary remedies.
    
(i)  The pursuit of or a successful action for interim, additional or
     supplementary remedies, or the filing of a court action, does not 
     constitute a waiver of the right of the Borrower or the Bank, including the
     suing party, to submit the controversy or claim to arbitration if the other
     party contests the lawsuit.  However, if the controversy or claim arises 
     from or relates to an obligation to the Bank which is secured by real 
     property located in California at the time of the proposed submission to 
     arbitration, this right is limited according to the provision above 
     requiring the consent of both the Borrower and the Bank to seek resolution 
     through arbitration.

(j)  If the Bank forecloses against any real property securing this Agreement,
     the Bank has the option to exercise the power of sale under the deed of 
     trust or mortgage, or to proceed by judicial foreclosure.


                                      -11-


9.5  SEVERABILITY; WAIVERS.  If any part of this Agreement is not enforceable,
the rest of the Agreement may be enforced.  The Bank retains all rights, even if
it makes a loan after default.  If the Bank waives a default, it may enforce a
later default.  Any consent or waiver under this Agreement must be in writing.

9.6  ADMINISTRATION COSTS.  The Borrower shall pay the Bank for all reasonable
costs incurred by the Bank in connection with administering this Agreement.

9.7  ATTORNEYS' FEES.  The Borrower shall reimburse the Bank for any reasonable
attorneys' fees and costs incurred by the Bank in connection with the
enforcement or preservation of any rights or remedies under this Agreement and
any other documents executed in connection with this Agreement, and including
any amendment, waiver, "workout" or restructuring under this Agreement.  In the
event of a lawsuit or arbitration proceeding, the prevailing party is entitled
to recover costs and reasonable attorneys' fees incurred in connection with the
lawsuit or arbitration proceeding, as determined by the court or arbitrator.  In
the event that any case is commenced by or against the Borrower under the
Bankruptcy Code (Title 11, United States Code) or any similar or successor
statute, the Bank is entitled to recover costs and reasonable attorneys' fees
incurred by the Bank related to the preservation, protection, or enforcement of
any rights of the Bank in such a case.  As used in this paragraph, "attorneys'
fees" includes the allocated costs of in-house counsel.

9.8  ONE AGREEMENT.  This Agreement and any related security or other agreements
required by this Agreement, collectively:

(a)  represent the sum of the understandings and agreements between the Bank and
     the Borrower concerning this credit; and

(b)  replace any prior oral or written agreements between the Bank and the
     Borrower concerning this credit; and

(c)  are intended by the Bank and the Borrower as the final, complete and
     exclusive statement of the terms agreed to by them.

In the event of any conflict between this Agreement and any other agreements
required by this Agreement, this Agreement will prevail.

9.9  NOTICES.  All notices required under this Agreement shall be personally
delivered or sent by first class mail, postage prepaid, to the addresses on the
signature page of this Agreement, or to such other addresses as the Bank and the
Borrower may specify from time to time in writing.

9.10 HEADINGS.  Article and paragraph headings are for reference only and shall
not affect the interpretation or meaning of any provisions of this Agreement.

This Agreement is executed as of the date stated at the top of the first page.


BANK OF AMERICA
NATIONAL TRUST AND SAVINGS ASSOCIATION     ARRIS PHARMACEUTICAL CORPORATION



X /s/ Stephanie Barrell                    X /s/ Daniel H. Petree
  ------------------------------------       -------------------------------
BY:     STEPHANIE BARRELL                  BY:     DANIEL H. PETREE    
TITLE:  VICE PRESIDENT                     TITLE:  EVP CORPORATE DEVELOPMENT 
                                                   AND CHIEF FINANCIAL OFFICER


                                     -12-



ADDRESS WHERE NOTICES TO THE BANK         ADDRESS WHERE NOTICES TO THE BORROWER
ARE TO BE SENT:                           ARE TO BE SENT:

San Francisco Commercial Banking          385 Olyster Point Blvd.
Office #1499                              South San Francisco, CA 94080 
345 Montgomery Street                  
San Francisco, CA 94104









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