EMPLOYMENT AGREEMENT


    EMPLOYMENT AGREEMENT ("Agreement") made and entered into by and between 
Apollo Genetics, Incorporated (the "Company"), a Delaware corporation with 
its principal place of business at 222 Third Street, Suite 3121, Cambridge, 
Massachusetts, and Katherine Gordon (the "Executive"), who resides at 395 
Broadway Street, Cambridge, Massachusetts, effective as of the 1st day of 
November, 1993 (the "Effective Date").

    WHEREAS, the operations of the Company and its Affiliates are a complex 
matter requiring direction and leadership in a variety of arenas, including 
financial, strategic planning, regulatory, community relations and others; 

    WHEREAS, the Executive is possessed of certain experience and expertise 
that qualify her to provide the direction and leadership required by the 
Company and its Affiliates; and 

    WHEREAS, subject to the terms and conditions hereinafter set forth, the 
Company therefore wishes to employ the Executive as its President and Chief 
Executive Officer and the Executive wishes to accept such employment; 

    NOW, THEREFORE, in consideration of the foregoing premises and the mutual 
promises, terms, provisions and conditions set forth in this Agreement, the 
parties hereby agree: 

    1. EMPLOYMENT. Subject to the terms and conditions set forth in this 
Agreement, the Company hereby offers and the Executive hereby accepts 
employment. 

    2. TERM.  Subject to earlier termination as hereafter provided, this 
Agreement shall have an original term of three (3) years commencing on the 
effective date hereof and shall be automatically extended thereafter for 
successive terms of two (2) years each, unless either party provides notice 
to the other at least ninety (90) days prior to the expiration of the 
original or any extension term that the Agreement is not to be extended. The 
term of this Agreement, as from time to time extended or renewed, is 
hereafter referred to as "the term of this Agreement" or "the term hereof".

    3. CAPACITY AND PERFORMANCE.

    a. During the term hereof, the Executive shall serve the Company as its 
President, Chief Executive Officer and a Director

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of the corporation.

    b. During the term hereof, the Executive shall be employed by the Company 
on a full-time basis and shall have all powers and duties consistent with 
such positions, subject to the direction of the Board.

    c. During the term hereof, the Executive shall devote her full business 
time and her best efforts, business judgment, skill and knowledge exclusively 
to the advancement of the business and interests of the Company and its 
Affiliates and to the discharge of her duties and responsibilities hereunder. 

    4. COMPENSATION AND BENEFITS. 

    a. BASE SALARY.  During the term hereof, the Company shall pay the 
Executive a base salary at the annual rate of $100,000 plus such other 
amounts, if any, as the Board of Directors of the Company, in its sole 
discretion, may from time to time determine.  The Executive's base salary 
shall be reviewed annually; provided, however, that in no event shall 
Executive's base salary be reduced below an annual rate of $100,000.  
Executive's salary shall be payable in bi-weekly installments or at such 
other frequency as the Company may from time to time determine for its senior 
executive officers as a group.

    b. BONUS COMPENSATION.  In addition to her base salary, the Executive 
shall receive a cash bonus to be awarded at the discretion of the Board of 
Directors. Issuance of the bonus shall be evaluated by the Board of Directors 
at least on an annual basis.     c. STOCK OPTIONS.  Executive shall be 
eligible to receive stock options as the Board of Directors shall determine 
at its sole discretion. 

    d. BUSINESS EXPENSES.  The Company shall pay or reimburse the Executive 
for all reasonable business expenses incurred or paid by the Executive in the 
performance of her duties and responsibilities hereunder, subject to any 
maximum annual limit and other restrictions on such expenses set by the Board 
and to such reasonable substantiation and documentation as may be specified 
by the Company from time to time. 

    e. INSURANCE.  The Company shall provide the Executive with, and pay the 
cost of, health, dental, life, and disability insurance as is generally made 
available to employees at levels similar to Executive's. 

    f. VACATIONS.  During the term hereof, the Executive shall be entitled to 
four (4) weeks of vacation per annum, to be taken at such times and intervals 
as shall be determined by the Executive, subject to the reasonable business 
needs of the Company.  One week of non-utilized vacation time may be carried

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over into the next year.  The Executive shall be entitled to cash 
compensation for one week of vacation time not taken during a given year.

    g. OTHER BENEFITS.  All other benefits offered to employees of the 
Company, including but not excluded to, paid vacations at designated 
holidays, shall be provided to the Executive.

    5. TERMINATION.  Notwithstanding the provisions of Section 2 hereof, the 
Executive's employment hereunder shall terminate prior to the expiration of 
the term under the following circumstances:

    a. DEATH.  In the event of the Executive's death during the term hereof, 
the Executive's employment hereunder shall immediately and automatically 
terminate.  In the event of the Executive's death during the term hereof, the 
Company shall pay to the Executive's designated beneficiary any earned and 
unpaid Base Salary, pro-rated through the date of her death.

    b. DISABILITY.

         i. The Company may terminate the Executive's employment hereunder 
through any illness, injury, accident or condition of either a physical or 
psychological nature and, as a result, is unable to perform substantially all 
of her duties and responsibilities hereunder for ninety (90) consecutive days 
during any period of three hundred and sixty-five (365) calendar days. 
Severance provisions of Section 5.d shall apply.

         ii. The Board may designate another employee to act in the 
Executive's place during any period of the Executive's disability.  
Notwithstanding any such designation, the Executive shall continue to receive 
the Base Salary in accordance with Section 4.a and benefits in accordance 
with Section 4.b - 4.g, to the extent permitted by the then-current terms of 
the applicable benefit plans, until the Executive becomes eligible for 
disability income benefits under the Company's disability income plan or 
until the termination of her employment, whichever shall first occur.

         iii. While receiving disability income payments under the Company's 
disability income plan, the Executive shall not be entitled to receive any 
Base Salary under Section 4.a hereof, but shall continue to participate in 
Company benefit plans in accordance with Section 4.b - 4.g and the terms of 
such plans, until the termination of her employment.

         iv. While receiving disability income payments under the Company's 
disability income plan and for as long as the Executive remains employed by 
the Company, the Company shall pay to the Executive the difference between 
60% of her Base Salary at the time the disability is incurred and the 
disability income

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benefits. This shall continue for the duration of the disability payments or 
until such time as employment is terminated. 

    c. BY THE COMPANY FOR CAUSE.  The Company may terminate the Executive's 
employment hereunder for Cause at any time upon notice to the Executive 
setting forth in reasonable detail the nature of such Cause.  The following, 
as determined by the Board in its reasonable judgment, shall constitute Cause 
for termination:

         i. Willful failure to perform, or gross negligence in the 
performance of, the Executive's duties and responsibilities to the Company 
and its Affiliates; 

         ii. Fraud, embezzlement or other material dishonesty with respect to 
the Company or any of its Affiliates; 

         iii. Conviction of, or plea or nolo contendere to, a felony or other 
crime involving moral turpitude. 

Upon the giving of notice of termination of the Executive's employment 
hereunder for Cause, the Company shall have no further obligation of 
liability to the Executive, other than for Based Salary and other benefits 
under this Agreement earned and unpaid at the date of termination. 

    d. BY THE COMPANY OTHER THAN FOR CAUSE.  The Company may terminate the 
Executive's employment hereunder other than for Cause at any time upon notice 
to the Executive.  In the event of such termination, the Company shall 
continue to pay the Executive the Base Salary at the rate in effect on the 
date of termination for a period of one year and shall continue to contribute 
to the cost of the Executive's participation in the Company's health, dental, 
life and disability insurance plans, provided that the Executive is entitled 
to continue such participation under applicable law and plan terms.  Notice 
by the Company that the Agreement is not to be extended as per Section 2 
shall constitute termination by the Company other than for cause. 

    e. BY THE EXECUTIVE FOR GOOD REASON.  The Executive may terminate her 
employment hereunder for Good Reason, upon notice to the Company setting 
forth in reasonable detail the nature of such Good Reason.  The following 
shall constitute Good Reason for termination by the Executive: 

         i. Failure of the Company to continue the Executive in the position 
of President and Chief Executive Officer; 

         ii. Material diminution in the nature or scope of the Executive's 
responsibilities, duties or authority; 

         iii. Material failure of the Company to provide the Executive the 
Based Salary and benefits in accordance with the terms of Section 4 hereof.

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In the event of termination in accordance with this Section 5.e, the Company 
shall continue to pay the Executive the Base Salary at the rate in effect of 
the date of termination for a period of one year and shall continue to 
contribute to the cost of the Executive's participation in the Company's 
health, dental, life and disability insurance plans, provided that the 
Executive is entitled to continue such participation under applicable law and 
plan terms. 

    g.  UPON CHANGE OF CONTROL. 

         iv. If a Change of Control occurs (as defined in Section 5.g.ii) 
and, within two years following such Change of Control, the Company 
terminates the Executive's employment other than for Cause, or the Executive 
terminates her employment for Good Reason, then, in lieu of any payments to 
or on behalf of the Executive under Section 5.d or 5.e hereof, the Company 
(A) shall pay the Executive, within ten business days of such termination, a 
lump sum payment equal to two and a half (2.5) times the sum of the Base 
Salary in effect at the date of such termination; and (B) shall pay the full 
cost of the Executive's continued participation in the Company's health, 
dental, life, and disability insurance plans for two and a half (2.5) years 
so long as the Executive remains entitled to continue such participation 
under applicable law. 

         v. A change of control ("Change of Control") shall be deemed to take 
place if hereafter (A) any Person or "group", other than the Company or any 
of its Affiliates, becomes a beneficial owner, directly or indirectly, of 
securities representing fifty percent (50%) or more of the total number of 
votes that may be cast for the election of directors of the Company; or (B) 
any merger or consolidation takes place involving the Company or any sale of 
all or substantially all of the assets of the Company or any combination of 
the foregoing in which the Company is not the surviving entity.

         vi. The Company shall promptly reimburse the Executive for the 
amount of all reasonable attorneys' fees and expenses incurred by the 
Executive in seeking to obtain or enforce any right or benefit provided the 
Executive under this Section 5.g.

    6. CONFIDENTIALITY .

    a. Beginning on the Effective Date, and at any time hereafter, the 
Executive shall treat as confidential any proprietary, confidential or secret 
information relating to the business or interests of the Company or any 
Affiliate of the Company, including, without limitation, the organizational 
structure, operations, business plans or technical projects of the Company or 
any subsidiary or Affiliate of the Company, and any research data or result, 
invention, trade secret, customer list, process or other work product 
developed by or for the

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Company or any subsidiary or Affiliate of the Company, whether on the 
premises of the Company or elsewhere ("Confidential Information"). Beginning 
on the Effective Date, and at any time hereafter, the Executive shall not 
disclose, utilize or make accessible in any manner or in any form any 
Confidential Information other than in connection with performing the 
services required of her under this Agreement, without the prior written 
consent of the Company.  Notwithstanding the foregoing, the provisions of 
this Section 6.a shall not apply to any proprietary, confidential or secret 
information or other research data or result, invention, trade secret, 
customer list or work product which is, at the commencement of this Agreement 
or at some later date, publically known under circumstances involving no 
breach of this Agreement or is lawfully and in good faith made available to 
Executive by a third party under no obligation of confidentiality with 
respect thereto. 

    b. All documents, records, apparatus, equipment and other physical 
property furnished to Executive by the Company or produced by Executive or 
others in connection with her employment shall be and remain the sole 
property of the Company.  Executive shall return and deliver such property to 
the Company as and when requested by the Company. 

    c. Executive agrees that the provisions of this Section 6 shall survive 
the termination of this employment and of this Agreement. 

    7. ASSIGNMENT OF RIGHTS TO INTELLECTUAL PROPERTY.  Executive hereby 
agrees that any and all information, inventions and discoveries, whether or 
not patentable, that she conceives and/or creates using the term hereof and 
any extensions thereof, and which are a direct or indirect result of work 
performed hereunder, shall be the sole and exclusive property of the Company. 
 Executive hereby assigns to the Company any and all right, title and 
interest which she has or may acquire in the same.  Executive further agrees 
that she will promptly execute any and all applications, assignments or other 
instruments which any officer of the Company or the Board of Directors of the 
Company shall deem necessary or useful in order to apply for and obtain 
Letters Patent in the United States and all foreign countries for said 
information, inventions and discoveries and in order to assign and convey to 
the Company the sole and exclusive right, title, and interest in and to said 
information, inventions, discoveries, patent applications and patents 
thereon.  The Company shall bear the cost of preparation of all such patent 
applications and assignments, and the cost of prosecution of all such patent 
applications in the United States patent office and in the patent offices of 
foreign countries. 

    8. NON-COMPETITION. 

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    a. Executive agrees that, during the period she is employed by the 
Company or any Affiliate of the Company, under this Agreement or otherwise, 
she will not engage in, or otherwise directly or indirectly be employed by, 
or act as a consultant, advisor or lender to, or be a director, officer, 
employee, stockholder, owner or partner of, any other business or 
organization, whether or not such business or organization now is or shall 
then be competing with the Company or Affiliate of the Company; provided, 
however, that Executive shall not be prohibited either from managing her own 
personal investments on her own personal time or from serving on up to two 
(2) outside boards of directors or advisory boards, so long as such 
activities do not (i) involve a business or organization which competes with 
the Company or any Affiliate of the Company, (ii) interfere or conflict with 
the performance of her duties as an employee of the Company or any subsidiary 
or Affiliate of the Company, (iii) otherwise result in a breach of any of the 
provisions of this Agreement, or (iv) in the case of serving as a director or 
advisory board member of other-companies, such activities for all such 
companies do not require, in the aggregate, more than ten (10) days per year, 
including travel time. 

Executive further agrees that if her employment with the Company is 
terminated by the Company pursuant to Section 5 hereof, or resigns or 
otherwise fails or refuses to perform the services required of her under this 
Agreement other than as a result of a breach of this Agreement by the Company 
(which breach is not cured within thirty (30) days after receiving notice 
thereof), then during the two-year period commencing on the date she ceases 
to be employed by the Company or any Affiliate of the Company, under this 
Agreement or otherwise, Executive shall not directly or indirectly compete 
with or be engaged in the same business as the Company its Affiliates, or be 
employed by, or act as consultant, advisor or lender to, or be a director, 
officer, employee, stockholder, owner or partner of, any business or 
organization which, at the time of such cessation, directly or indirectly 
competes with or is engaged in the same business as the Company or any 
subsidiary or Affiliate of the Company; PROVIDED, HOWEVER, that if 
Executive's employment with the Company is terminated pursuant to Section 5 
hereof, Executive's obligations pursuant to this sentence shall continue only 
so long as the Company pays Executive compensation at the same rate 
compensation was being paid to her pursuant to Section 4.a of this Agreement 
at the time of such termination.

    b. Executive agrees that for a period of three years from the termination 
of this Agreement she will not, directly or indirectly, employ or solicit the 
employment or engagement by others of any employees of, or consultants hired 
by, the Company, or any subsidiary or Affiliate of the Company, without the 
prior written consent of the Company, unless such person ceased to be 
employed or engaged by the Company or its subsidiary or Affiliate at least 
four (4) months prior to the solicitation.

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    9. REPRESENTATIONS AND WARRANTIES.  Executive represents and warrants to 
the Company that (i) Executive is under no contractual or other restriction 
or obligation which is inconsistent with the execution of this Agreement, the 
performance of her duties hereunder or the other rights of the Company and 
any subsidiary or Affiliate of the Company hereunder, and (ii) Executive is 
under no physical or mental disability that would hinder the performance by 
her of her duties under this Agreement.

    10. ASSIGNMENT.  Neither the Company nor the Executive may make any 
assignment of this Agreement or any interest herein, by operation of law or 
otherwise, without the prior written consent of the other; provided, however, 
that the Company may assign its rights and obligations under this Agreement 
without the consent of the Executive Clothe event that the Company shall 
hereafter affect a reorganization, consolidate with, or merge into, any other 
Person or transfer all or substantially all of its properties or assets to 
any other Person. This Agreement shall inure to the benefit of and be binding 
upon the Company and the administrators, heirs and permitted assigns.

    11. SEVERABILITY.  If any portion or provision of this Agreement shall to 
any extent be declared illegal or unenforceable by a court of competent 
jurisdiction, then the remainder of this Agreement, or the application of 
such portion or provision in circumstances other than those as to which it is 
so declared illegal or unenforceable, shall not be affected thereby, and each 
portion and provision of this Agreement shall be valid and enforceable to the 
fullest extent permitted by law.

    12. WAIVER. No waiver of any provision hereof shall be effective unless 
made in writing and signed by the waiving party. The failure of either party 
to require the performance of any term or obligation of this Agreement, or 
the waiver by either party of any breach of this Agreement, shall not prevent 
any subsequent enforcement of such term or obligation or be deemed a waiver 
of any subsequent breach. 

    13. NOTICES.  Any and all notices, requests, demands and other 
communications provided for by this Agreement shall be in writing and shall 
be effective when delivered in person or deposited in the United States mail, 
postage prepaid, registered or certified, and addressed to the Executive at 
her last known address on the books of the Company or, in the case of the s 
Company, at its principal place of business, or to such other address as 
either party may specify by notice to the other. 

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    14. ENTIRE AGREEMENT.  This Agreement constitutes the entire agreement 
between the parties and supersedes all prior communications, agreements and 
understandings, written or oral, with respect to the terms and conditions of 
the Executive's employment. 

    15. AMENDMENT.  This Agreement may be amended or modified only by a 
written instrument signed by the Executive and by a expressly authorized 
representative of the Company.

    16. HEADINGS.  The headings and captions in-this Agreement are for 
convenience only and in no way define or describe the scope or content of any 
provision of this Agreement. 

    17. COUNTERPARTS.  This Agreement may be executed in two or more 
counterparts, each of which shall be an original and all of which together 
shall constitute one and the same instrument. 

    18. GOVERNING LAW.  This is a Massachusetts contract and shall be 
construed and enforced under and be governed in all respects by the laws of 
the Commonwealth of Massachusetts, without regard to the conflict of laws 
principles thereof. 











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    IN WITNESS WHEREOF, this Agreement has been executed as a sealed 
instrument by the Company, by its duly authorized representative, and by the 
Executive, as of the date first above written. 

THE EXECUTIVE:                       THE COMPANY:



  /s/ Katherine Gordon                  By:    /S/ Alan Gelband
- --------------------------                  --------------------------------

                                     Title:    Chief Financial Officer
                                            --------------------------------














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