AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

                                  OF

                        APOLLO GENETICS, INC.

               INCORPORATED PURSUANT TO AN ORIGINAL
                   CERTIFICATE OF INCORPORATION
                 FILED WITH THE SECRETARY OF STATE
                   OF DELAWARE ON JULY 20, 1992


     We, the undersigned, for the purpose of amending and restating the 
Certificate of Incorporation of Apollo Genetics, Inc. (the "Corporation") 
under the laws of the State of Delaware hereby certify as follows:

     FIRST.  The name of the Corporation is:

                   Apollo BioPharmaceutics, Inc.

     SECOND.  The address of its registered office in the State of Delaware 
is Corporation Trust Center, 1209 Orange Street, in the City of Wilmington, 
County of New Castle.  The name of its registered agent at such address is 
The Corporation Trust Company.

     THIRD.  The nature of the business or purposes to be conducted or 
promoted by the Corporation is as follows:

     To engage in any lawful act or activity for which corporations may be 
organized under the General Corporation Law of Delaware.

     FOURTH:  The total number of shares of all classes of stock which the 
Corporation shall have authority to issue is (i) 20,000,000 shares of Common 
Stock, $0.02 par value per share ("Common Stock") and (ii) 1,000,000 shares 
of Preferred Stock, $0.01 par value per share ("Preferred Stock").

     Upon the effectiveness of this Restated Certificate of Incorporation, 
each three and one-third (3 1/3) issued and outstanding shares of Common 
Stock of the Corporation shall thereby be combined into one (1) validly 
issued, fully paid, and nonassessable shares of Common Stock of the 
Corporation.  No scrip or fractional shares will be issued, and each 
fractional share resulting from such combination shall be redeemed by the 
Corporation for cash at a price per share equal to the price to the public in 
the initial public offering of the Corporation's Common Stock.  There shall 
not be any change in the number of shares authorized by reason of such 
combination.




     The following is a statement of the designations and the powers, 
privileges and rights, and the qualifications, limitations or restrictions 
thereof in respect of each class of capital stock of the Corporation.

     A.   COMMON STOCK.

          1.   GENERAL.  The voting, dividend and liquidation rights of the 
holders of the Common Stock are subject to and qualified by the rights of the 
holders of the Preferred Stock of any series as may be designated by the 
Board of Directors upon any issuance of the Preferred Stock of any series.

          2.   VOTING.  The holders of the common stock are entitled to one 
vote for each share held at all meetings of stockholders (and written actions 
in lieu of meetings).  There shall be no cumulative voting.

     The number of authorized shares of Common Stock may be increased or 
decreased (but not below the number of shares thereof then outstanding) by 
the affirmative vote of the holders of a majority of the stock of the 
Corporation entitled to vote, irrespective of the provisions of Section 
242(b)(2) of the General Corporation Law of Delaware.

          3.   DIVIDENDS.  Dividends may be declared and paid on the Common 
Stock from funds lawfully available therefor as and when determined by the 
Board of Directors and subject to any preferential dividend rights of any 
then outstanding Preferred Stock.

          4.   LIQUIDATION.  Upon the dissolution or liquidation of the 
Corporation, whether voluntary or involuntary, holders of Common Stock will 
be entitled to receive all assets of the Corporation available for 
distribution to its stockholders, subject to any equivalent or preferential 
rights of any then outstanding Preferred Stock.

     B.   PREFERRED STOCK.

     Preferred Stock may be issued from time to time in one or more series, 
each of such series to have such terms as stated or expressed herein and in 
the resolution or resolutions providing for the issue of such series adopted 
by the Board of Directors of the Corporation as hereinafter provided.  Any 
shares of Preferred Stock which may be redeemed, purchased or otherwise 
acquired by the Corporation may be reissued except as otherwise provided by 
law.  Different series of Preferred Stock shall not be construed to 
constitute different classes of shares for the purposes of voting by classes 
unless expressly provided.

     Authority is hereby expressly granted to the Board of Directors, from 
time to time, to issue the Preferred Stock in one or more series, and in 
connection with the creation of any such series, by resolution or resolutions 
providing for the issue of the shares thereof, to determine and fix such 
voting powers, full or limited, or no voting powers, and such designations, 
preferences and relative participating, optional or other special rights, and 
qualifications, limitations or restrictions thereof, including, without 
limitation thereof, dividend rights, special voting rights, conversion 
rights, redemption privileges and liquidation preferences, as shall be stated 
and expressed in such resolutions, all to the full extent now or 

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hereafter permitted by the General Corporation Law of Delaware.  Without 
limiting the generality of the foregoing, the resolutions providing for 
issuance of any series of Preferred Stock may provide that such series shall 
be superior or rank equally or be junior to the Preferred Stock of any other 
series to the extent permitted by law.  Except as otherwise specifically 
provided in this Amended and Restated Certificate of Incorporation, no vote 
of the holders of the Preferred Stock or Common Stock shall be a prerequisite 
to the issuance of any shares of any series of the Preferred Stock authorized 
by and complying with the conditions of this Amended and Restated Certificate 
of Incorporation, the right to have such voting being expressly waived by all 
present and future holders of the capital stock of the Corporation.

     FIFTH.  In furtherance of and not in limitation of powers conferred by 
statute, it is further provided:

          1.   Election of directors need not be by written ballot; and

          2.   The directors shall be divided into three classes, as nearly 
equal in number as the then total number of directors constituting the entire 
Board permits, with the term of office of one class expiring each year.  The 
initial Class I directors elected by the stockholders of the Corporation 
shall hold office for a term expiring at the 1997 annual meeting of 
stockholders; the initial Class II directors elected by the stockholders of 
the Corporation shall hold office for a term expiring at the 1998 annual 
meeting of stockholders; and the initial Class III directors elected by the 
stockholders of the Corporation shall hold office for a term expiring at the 
1999 annual meeting of stockholders.  At each such annual meeting of 
stockholders and at each annual meeting thereafter, successors to the class 
of directors whose term expires at that meeting shall be elected for a term 
expiring at the third annual meeting following their election and until their 
successors shall be elected and qualified, subject to prior death, 
resignation, retirement or removal.  If the number of directors is changed, 
any increase or decrease shall be apportioned among the classes so as to 
maintain the number of directors in each class as nearly equal as possible, 
but in no event will a decrease in the number of directors shorten the term 
of any incumbent director.  Notwithstanding the foregoing, and except as 
otherwise required by law, whenever the holders of any one or more series of 
Preferred Stock shall have the right, voting separately as a class, to elect 
one or more directors of the Corporation, the election, terms of office and  
other features of such directorships shall be governed by the terms of the 
vote establishing such series, and such directors so elected shall not be 
divided into classes pursuant to this Article unless expressly provided by 
such terms.  This Section 2 of Article may not be amended, revised or 
revoked, in whole or in part, except by the affirmative vote of the holders 
of 80% of the voting power of the shares of all classes of stock of the 
Corporation entitled to vote for the election of directors, considered for 
the purposes of this Article as one class of stock.

          3.   Each director chosen to fill a vacancy in the Board of Directors
shall be elected to complete the term of office of the director who is being
succeeded.  In the case of any election of a new director to fill a directorship
created by an enlargement of the Board, the Board shall in such election assign
the class of directors to which such additional director

                                    -3-


is being elected, and each director so elected shall hold office for the same 
term as the other members of the class to which the director is assigned.

          4.   Except as otherwise determined by the Board of Directors in 
establishing a series of Preferred Stock as to directors elected by holders 
of such series, at any special meeting of the stockholders called at least in 
part for the purpose, any director or directors may, by the affirmative vote 
of the holders of at least a majority of the stock entitled to vote for the 
election of directors, by removed from office for cause.  The provisions of 
this subsection shall be the exclusive method for the removal of directors.  
This Section 4 of Article may not be amended, revised or revoked, in whole or 
in part, except by the affirmative vote of the holders of 80% of the voting 
power of the shares of all classes of stock of the Corporation entitled to 
vote for the election of directors, considered for the purposes of this 
Article as one class of stock.

          5.   The Board of Directors is expressly authorized to adopt, amend 
or repeal the By-Laws of the Corporation.

     SIXTH.  Whenever a compromise or arrangement is proposed between the 
Corporation and its creditors or any class of them and/or between the 
Corporation and its stockholders or any class of them, any court of equitable 
jurisdiction within the State of Delaware may, on the application in a 
summary way of the Corporation or of any creditor or stockholder thereof, or 
on the application of any receiver or receivers appointed for the Corporation 
under the provisions of section 291 of Title 8 of the Delaware Code or on the 
application of trustees in dissolution or of any receiver or receivers 
appointed for the Corporation under the provisions of section 279 of Title 8 
of the Delaware Code order a meeting of the creditors or class of creditors, 
and/or of the stockholders or class of stockholders of the Corporation, as 
the case may be, to be summoned in such manner as the said court directs.  If 
a majority in number representing three-fourths in value of the creditors or 
class of creditors, and/or of the stockholder or class of stockholders of the 
Corporation, as the case may be, agree to any compromise or arrangement and 
to any reorganization of the Corporation as consequence of such compromise or 
arrangement, the said compromise or arrangement and the said reorganization 
shall, if sanctioned by the court to which the said application has been 
made, be binding on all the creditors or class of creditors, and/or on all 
the stockholders or class of stockholders, of the Corporation, as the case 
may be, and also on the Corporation.

     SEVENTH.  Except to the extent that the General Corporation Law of 
Delaware prohibits the elimination or limitation of liability of directors 
for breaches of fiduciary duty, no director of the Corporation shall be 
personally liable to the Corporation or its stockholders for monetary damages 
for any breach of fiduciary duty as a director, notwithstanding any provision 
of law imposing such liability.  No amendment to or repeal of this provision 
shall apply to or have any effect on the liability or alleged liability of 
any director of the Corporation for or with respect to any acts or omissions 
of such director occurring prior to such amendment.


                                    -4-



     EIGHTH:   No action required to be taken or that may be taken at any 
annual or special meeting of stockholders of the Corporation may be taken by 
written consent without a meeting, and the power of stockholders to consent 
in writing, without a meeting, to the taking of any action is specifically 
denied.

     This Article may not be amended, revised or revoked, in whole or in 
part, except by the affirmative vote of the holders of 80% of the voting 
power of the shares of all classes of stock of the Corporation entitled to 
vote for the election of directors, considered for the purposes of this 
Article as one class of stock.

     NINTH.  1.     ACTIONS, SUITS AND PROCEEDINGS OTHER THAN BY OR IN THE 
RIGHT OF THE CORPORATION.  The Corporation shall indemnify each person who 
was or is a party or is threatened to be made a party to any threatened, 
pending or completed action, suit or proceeding, whether civil, criminal, 
administrative or investigative (other than an action by or in the right of 
the Corporation), by reason of the fact that he is or was, or has agreed to 
become, a director or officer of the Corporation, or is or was serving, or 
has agreed to serve, at the request of the Corporation, as a director, 
officer or trustee of, or in a similar capacity with, another corporation, 
partnership, joint venture, trust or other enterprise (including any employee 
benefit plan) (each such person being referred to hereinafter as an 
"Indemnitee"), or by reason of any action alleged to have been taken or 
omitted in such capacity, against all expenses (including attorneys' fees), 
judgments, fines and amounts paid in settlement actually and reasonably 
incurred by him or on his behalf in connection with such action, suit or 
proceeding and may appeal therefrom, if he acted in good faith and in a 
manner he reasonably believed to be in, or not opposed to, the best interests 
of the Corporation, and, with respect to any criminal action or proceeding, 
had no reasonable cause to believe his conduct was unlawful.  The termination 
of any action, suit or proceeding by judgment, order, settlement, conviction 
or upon a plea of NOLO CONTENDERE or its equivalent, shall not, of itself, 
create a presumption that the person did not act in good faith and in a 
manner which he reasonably believed to be in, or not opposed to, the best 
interests of the Corporation, and, with respect to any criminal action or 
proceeding, had reasonable cause to believe that his conduct was unlawful.  
Notwithstanding anything to the contrary in this Article, except as set forth 
in Section 6 below, the Corporation shall not indemnify an Indemnitee seeking 
indemnification in connection with a proceeding (or part thereof) initiated 
by the Indemnitee unless the initiation thereof was approved by the Board of 
Directors of the Corporation.

     2.   ACTIONS OR SUITS BY OR IN THE RIGHT OF THE CORPORATION.  The 
Corporation shall indemnify any Indemnitee who was or is a party or is 
threatened to be made a party to any threatened, pending or completed action 
or suit by or in the right of the Corporation to procure a judgment in its 
favor by reason of the fact that he is or was, or has agreed to become, a 
director or officer of the Corporation, or is or was serving, or has agreed 
to serve, at the request of the Corporation, as a director, officer or 
trustee of, or in a similar capacity with, another corporation, partnership, 
joint venture, trust or other enterprise (including any employee benefit 
plan), or by reason of any action alleged to have been taken or omitted in 
such capacity, against all expenses (including attorneys' fees) and amounts 
paid in settlement actually and reasonably incurred by him or on his behalf 
in connection with such action, suit or proceeding and any appeal therefrom, 
if he acted in good faith and in a

                                    -5-



manner he reasonably believed to be in, or not opposed to, the best interests 
of the Corporation, except that no indemnification shall be made in respect 
of any claim, issue or matter as to which such person shall have been 
adjudged to be liable to the Corporation unless and only to the extent that 
the Court of Chancery of Delaware or the court in which such action or suit 
was brought shall determine upon application that, despite the adjudication 
of such liability and in view of all the circumstances of the case, such 
person is fairly and reasonably entitled to indemnity for such expenses 
(including attorneys' fees) which the Court of Chancery of Delaware or such 
other court shall deem proper.

     3.   INDEMNIFICATION FOR EXPENSES OF SUCCESSFUL PARTY.  Notwithstanding 
the other provisions of this Article, to the extent that an Indemnitee has 
been successful, on the merits or otherwise, in defense of any action, suit 
or proceeding referred to in Sections 1 and 2 of this Article, or in defense 
of any claim, issue or matter therein, or on appeal from any such action, 
suit or proceeding, he shall be indemnified against all expenses (including 
attorneys' fees) actually and reasonably incurred by him or on his behalf in 
connection therewith.  Without limiting the foregoing, if any action, suit or 
proceeding is disposed of, on the merits or otherwise (including a 
disposition without prejudice), without (i) the disposition being adverse to 
the Indemnitee, (ii) an adjudication that the Indemnitee was liable to the 
Corporation, (iii) a plea of guilty or NOLO CONTENDERE by the Indemnitee, 
(iv) an adjudication that the Indemnitee did not act in good faith and in a 
manner he reasonably believed to be in or not opposed to the best interest of 
the Corporation, and (v) with respect to any criminal proceeding, an 
adjudication that the Indemnitee had reasonable cause to believe his conduct 
was unlawful, the Indemnitee shall be considered for the purposes hereof to 
have been wholly successful with respect thereto.

     4.   NOTIFICATION AND DEFENSE OF CLAIM.  As a condition precedent to his 
right to be indemnified, the Indemnitee must notify the Corporation in 
writing as soon as practicable of any action, suit, proceeding or 
investigation involving him for which indemnity will or could be sought.  
With respect to any action, suit, proceeding or investigation of which the 
Corporation is so notified, the Corporation will be entitled to participate 
therein at his own expense and/or to assume the defense thereof at its own 
expense, with legal counsel reasonably acceptable to the Indemnitee.  After 
notice from the Corporation to the Indemnitee of its election so to assume 
such defense, the Corporation shall not be liable to the Indemnitee for any 
legal or other expenses subsequently incurred by the Indemnitee in connection 
with such claim, other than as provided below in this Section 4.  The 
Indemnitee shall have the right to employ his own counsel in connection with 
such claim, but the fees and expenses of such counsel incurred after notice 
from the Corporation of its assumption of the defense thereof shall be at the 
expense of the Indemnitee unless (i) the employment of counsel by the 
Indemnitee has been authorized by the Corporation, (ii) counsel to the 
Indemnitee shall have reasonably concluded that there may be a conflict of 
interest or position on any significant issue between the Corporation and the 
Indemnitee in the conduct of the defense of such action or (iii) the 
Corporation shall not in fact have employed counsel to assume the defense of 
such action, in each of which cases the fees and expenses of counsel for the 
Indemnitee shall be at the expense of the Corporation, except as otherwise 
expressly provided by this Article.  The Corporation shall not be entitled, 
without the consent of the

                                     -6-



Indemnitee, to assume the defense of any claim brought by or in the right of 
the Corporation or as to which counsel for the Indemnitee shall have 
reasonably made the conclusion provided for in clause (ii) above.

     5.   ADVANCE OF EXPENSES.  Subject to the provisions of Section 6 below, 
in the event that the Corporation does not assume the defense pursuant to 
Section 4 of this Article of any action, suit, proceeding or investigation of 
which the Corporation receives notice under this Article, any expenses 
(including attorneys' fees) incurred by an Indemnitee in defending a civil or 
criminal action, suit, proceeding or investigation or any appeal therefrom 
shall be paid by the Corporation in advance of the final disposition of such 
matter, PROVIDED, HOWEVER, that the payment of such expenses incurred by an 
Indemnitee in advance of the final disposition of such matter shall be made 
only upon receipt of an undertaking by or on behalf of the Indemnitee to 
repay all mounts so advanced in the event that it shall ultimately be 
determined that the Indemnitee is not entitled to be indemnified by the 
Corporation as authorized in this Article. Such undertaking may be accepted 
without reference to the financial ability of such person to make such 
repayment.

     6.   PROCEDURE FOR INDEMNIFICATION.  In order to obtain indemnification 
or advancement of expenses pursuant to Section 1, 2, 3 or 5 of this Article, 
the Indemnitee shall submit to the Corporation a written request, including 
in such request such documentation and information as is reasonably available 
to the Indemnitee and is reasonably necessary to determine whether and to 
what extent the Indemnitee is entitled to indemnification or advancement of 
expenses.  Any such indemnification or advancement of expenses shall be made 
promptly, and in any event within 60 days after receipt by the Corporation or 
the written request of the Indemnitee, unless with respect to requests under 
Section 1, 2 or 5 the Corporation determines, by clear and convincing 
evidence, within such 60-day period that the Indemnitee did not meet the 
applicable standard of conduct set forth in Section 1 or 2, as the case may 
be.  Such determination shall be made in each instance by (a) a majority vote 
of a quorum of the directors of the Corporation consisting of persons who are 
not at that time parties to the action, suit or proceeding in question 
("disinterested directors"), (b) if not such quorum is obtainable, a majority 
vote of a committee of two or more disinterested directors, (c) a majority 
vote of a quorum of the outstanding shares of stock of all classes entitled 
to vote for directors, voting as a single class, which quorum shall consist 
of stockholders who are not at that time parties to the action, suit or 
proceeding in question, (d) independent legal counsel (who may be regular 
legal counsel to the Corporation), or (e) a court of competent jurisdiction.

     7.   REMEDIES.  The right to indemnification or advances as granted by 
this Article shall be enforceable by the Indemnitee in any court of competent 
jurisdiction if the Corporation denies such request, in whole or in part, or 
if no disposition thereof is made within the 60-day period referred to above 
in Section 6.  Unless otherwise provided by law, the burden of proving that 
the Indemnitee is not entitled to indemnification or advancement of expenses 
under this Article shall be on the Corporation.  Neither the failure of the 
Corporation to have made a determination prior to the commencement of such 
action that indemnification is proper in the circumstances because the 
Indemnitee has met the applicable standard of conduct, nor an actual 
determination by the Corporation pursuant to Section 6 that the Indemnitee 
has not met such applicable standard of conduct, shall be a defense to the 

                                    -7-




action or create a presumption that the Indemnitee has not met the applicable 
standard of conduct.  The Indemnitee's expenses (including attorneys' fees) 
incurred in connection with successfully establishing his right to 
indemnification, in whole or in part, in any such proceeding shall also be 
indemnified by the Corporation.

     8.   SUBSEQUENT AMENDMENT.  No amendment, termination or repeal of this 
Article or of the relevant provisions of the General Corporation Law of 
Delaware or any other applicable laws shall affect or diminish in any way the 
rights of any Indemnitee to indemnification under the provisions hereof with 
respect to any action, suit, proceeding or investigation arising out of or 
relating to any actions, transactions or facts occurring prior to the final 
adoption of such amendment, termination or repeal.

     9.   OTHER RIGHTS.  The indemnification and advancement of expenses 
provided by this Article shall not be deemed exclusive of any other rights to 
which an Indemnitee seeking indemnification or advancement of expenses may be 
entitled under any law (common or statutory), agreement or vote of 
stockholders or disinterested directors or otherwise, both as to action in 
his official capacity and as to action in any other capacity while holding 
office for the Corporation, and shall continue as to an Indemnitee who has 
ceased to be a director or officer, and shall inure to the benefit of the 
estate, heirs, executors and administrators of the Indemnitee.  Nothing 
contained in this Article shall be deemed to prohibit or limit, and the 
Corporation is specifically authorized to enter into, agreements with 
officers and procedures different from those set forth in this Article.  In 
addition, the Corporation may, to the extent authorized from time to time by 
its Board of Directors, grant indemnification rights to other employees or 
agents of the Corporation or other persons serving the Corporation and such 
rights may be equivalent to, or greater or less than, those set forth in this 
Article.

     10.  PARTIAL INDEMNIFICATION.  If an Indemnitee is entitled under any 
provision of this Article to indemnification by the Corporation for some or a 
portion of the expenses (including attorneys' fees), judgments, fines or 
amounts paid in settlement actually and reasonably incurred by him or on his 
behalf in connection with any action, suit, proceeding or investigation and 
any appeal therefrom but not, however, for the total amount thereof, the 
Corporation shall nevertheless indemnify the Indemnitee for the portion of 
such expenses (including attorneys' fees), judgments, fines or amounts paid 
in settlement to which the Indemnitee is entitled.

     11.  INSURANCE.  The Corporation may purchase and maintain insurance, at 
its expense, to protect itself and any director, officer, employee or agent 
of the Corporation or another corporation, partnership, joint venture, trust 
or other enterprise (including any employee benefit plan) against any 
expense, liability or loss incurred by him in any such capacity,or arising 
out of his status as such, whether or not the Corporation would have the 
power to indemnify such person against such expense, liability or loss under 
the General Corporation Law of Delaware.


                                    -8-




     12.  MERGER OR CONSOLIDATION.  If the Corporation is merged into or 
consolidated with another corporation and the Corporation is not the 
surviving corporation, the surviving corporation shall assume the obligations 
of the Corporation under this Article with respect to any action, suit, 
proceeding or investigation arising out of or relating to any actions, 
transactions or facts occurring prior to the date of such merger or 
consolidation.

     13.  SAVINGS CLAUSE.  If this Article or any portion hereof shall be 
invalidated on any ground by any court of competent jurisdiction, then the 
Corporation shall nevertheless indemnify each Indemnitee as to any expenses 
(including attorneys' fees), judgments, fines and amounts paid in settlement 
in connection with any action, suit, proceeding or investigation, whether 
civil, criminal or administrative, including an action by or in the right of 
the Corporation, to the fullest extent permitted by any applicable portion of 
this Article that shall not have been invalidated and to the fullest extent 
permitted by applicable law.

     14.  DEFINITIONS.  Terms used herein and defined in Section 145(h) and 
Section 145(i) of the General Corporation Law of Delaware shall have the 
respective meanings assigned to such terms in such Section 145(h) and Section 
145(i).

     15.  SUBSEQUENT LEGISLATION.  If the General Corporation Law of Delaware 
is amended after adoption of this Article to expand further the 
indemnification permitted to Indemnities, then the Corporation shall 
indemnify such persons to the fullest extent permitted by the General 
Corporation Law of Delaware, as so amended.

     TENTH.  The Corporation reserves the right to amend, alter, change or 
repeal any provision contained in this Certificate of Incorporation, in the 
manner now or hereafter prescribed by statute and this Certificate of 
Incorporation, and all rights conferred upon stockholders herein are granted 
subject to this reservation.

     ELEVENTH.  Section 203 of the General Corporation of Law of Delaware, as 
it may be amended from time to time, shall apply to the Corporation.

     EXECUTED in the city of Cambridge, Massachusetts, on the 9th day of 
December, 1996.

                                         /s/  Katherine Gordon
                                         ---------------------------
                                         Katherine Gordon
                                         President

ATTESTED:

/s/ Michael Lytton
- ----------------------------
Secretary