[SUBJECT TO STOCKHOLDER APPROVAL]


                                APOLLO GENETICS, INC.
                                           
                                 AMENDED AND RESTATED
                  1993 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN
                                           
1.  PURPOSE

    The purpose of this Amended and Restated 1993 Incentive and Non-Qualified 
Option Plan (the "Plan") is to encourage and enable selected management, 
other key employees, directors (whether or not employees), and consultants of 
Apollo Genetics, Inc. (the "Company") or a parent or subsidiary of the 
Company to acquire a proprietary interest in the Company through the 
ownership of common stock, par value $.02 per share (the "Common Stock"), of 
the Company. Such ownership will provide such employees, directors, and 
consultants with a more direct stake in the future welfare of the Company, 
and encourage them to remain with the Company or a parent or subsidiary of 
the Company. It is also expected that the Plan will encourage qualified 
persons to seek and accept employment with, or become associated with, the 
Company or a parent or subsidiary of the Company. Pursuant to the Plan, such 
persons may be offered the opportunity to acquire Common Stock through the 
grant of incentive stock options and "non-qualified" stock options.

    As used herein, the term "parent" or "subsidiary" shall mean any present 
or future corporation which is or would be a "parent corporation" or 
"subsidiary corporation" of the Company as the term is defined in Section 425 
of the Internal Revenue Code of 1986, as amended (the "Code") (determined as 
if the Company were the employer corporation). 

2.  ADMINISTRATION OF PLAN

    The Plan shall be administered by a Compensation Committee (the 
"Committee") as appointed from time to time by the Board of Directors of the 
Company, which committee shall consist of not less than two members of the 
Board of Directors and each member of which shall be a "Non-Employee 
Director," within the meaning of Rule 16b-3 promulgated under the Securities 
Exchange Act of 1934, as amended (the "Exchange Act"), or any successor rule 
or regulation ("Rule 16b-3"). Except as otherwise specifically provided 
herein, no person, other than members of the Committee, shall have any 
discretion as to decisions regarding the Plan. 

    In administering the Plan, the Committee may adopt rules and regulations 
for carrying out the Plan. The interpretation and decision made by the 
Committee with regard to any question arising under the Plan shall be final 
and conclusive on all persons participating or eligible to participate in the 
Plan. Subject to the provisions of the Plan, the Committee shall determine 
the terms of all options granted pursuant to the Plan, including, but not 
limited to, the persons to whom, and the time or times at which, grants shall 
be made, the number of options to be included in the grants, the number of 
options which shall be treated as incentive stock options, and the exercise 
price. 




3.  SHARES OF STOCK SUBJECT TO THE PLAN

    Except as provided in subparagraphs 6(h) and 6(i) and paragraph 7, the 
number of shares that may be issued or transferred pursuant to the exercise 
of options granted under the Plan shall not exceed 600,000 shares of Common 
Stock. Such shares may be authorized and unissued shares or previously issued 
shares acquired or to be acquired by the Company and held in treasury. Any 
shares subject to an option which for any reason expires or is terminated 
unexercised as to such shares may again be subject to an option right under 
the Plan. The aggregate Fair Market Value (determined at the time the option 
is granted) of the stock with respect to which incentive stock options are 
exercisable for the first time by an optionee during any calendar year (under 
the Plan and all plans of the Company and any parent and subsidiary of the 
Company) shall not exceed $100,000. 

4.  ELIGIBILITY

    Incentive stock options may be granted only to management and other key 
employees who are employed by the Company or a parent or subsidiary of the 
Company. An incentive stock option may be granted to a director of the 
Company or a parent or subsidiary of the Company, provided that the director 
is also an officer or key employee. Directors who are not officers or key 
employees, and consultants, may only be granted non-qualified stock options. 

5.  GRANTING OF OPTIONS

    No options pursuant to this Plan may be granted after the expiration of 
business on the tenth anniversary of the effective date of the Plan. The date 
of the grant of any option shall be the date on which the Committee 
authorizes the grant of such option. 

6.  OPTIONS

    Options shall be evidenced by stock option certificates or agreements in 
such form, not inconsistent with this Plan, as the Committee shall approve 
from time to time, which agreements need not be identical, and shall be 
subject to the following terms and conditions: 

    (a)  EXERCISE PRICE.  The exercise price under each incentive stock 
option shall be not less than 100% of the Fair Market Value of the Common 
Stock at the time the option is granted and not less than par value of such 
Common Stock. In the case of an incentive stock option granted to an employee 
owning more than 10% of the total combined voting power of all classes of 
stock of the Company or of any parent or subsidiary of the Company (a "10% 
Stockholder") actually or constructively under Section 425(d) of the Code, 
the exercise price shall not be less than 110% of the Fair Market Value of 
the Common Stock subject to the option at the time of its grant. The purchase 
price under each non-qualified stock option shall be specified by the 
Committee, but shall in no case be less than the greater of 50% of the Fair 
Market Value of the Common Stock at the time the option is granted and the 
par value of such Common Stock.




    (b)  MEDIUM AND TIME OF PAYMENT.  Stock purchased pursuant to the 
exercise of an option shall at the time of purchase be paid for in full in 
cash, or, upon conditions established by the Committee, by delivery of shares 
of Common Stock owned by the recipient. If payment is made by the delivery of 
shares, the value of the shares delivered shall be the Fair Market Value of 
such shares on the date of exercise of the respective option. Upon receipt of 
payment and such documentation as the Company may deem necessary to establish 
compliance with the Securities Act of 1933, as amended (the "Securities 
Act"), the Company shall, without stock transfer tax to the optionee or other 
person entitled to exercise the option, deliver to the person exercising the 
option a certificate or certificates for such shares. It shall be a condition 
to the performance of the Company's obligation to issue or transfer Common 
Stock upon exercise of an option or options that the optionee pay, or make 
provision satisfactory to the Company for the payment of, any taxes (other 
than stock transfer taxes) which the Company is obligated to collect with 
respect to the issue or transfer of Common Stock upon such exercise, 
including any federal, state, or local withholding taxes.

    (c)  WAITING PERIOD.  The waiting period and time for exercising an 
option shall be prescribed by the Committee in each particular case; 
provided, however, that no option may be exercised after ten years from the 
date it is granted. In the case of an incentive stock option granted to a 10% 
Stockholder, such option, by its terms, shall be exercisable only within five 
years from the date of grant.

    (d)  RIGHTS AS A STOCKHOLDER.  A recipient of options shall have no 
rights as a stockholder with respect to any shares issuable or transferable 
upon exercise thereof until the date a stock certificate is issued to him for 
such shares.  Except as otherwise expressly provided in the Plan, no 
adjustment shall be made for dividends or other rights for which the record 
date is prior to the date such stock certificate is issued.

    (e)  NON-ASSIGNABILITY OF OPTIONS.  No option shall be assignable or
transferable by 4$ s the recipient except by will or by the laws of descent and
distribution. During the lifetime of a recipient, options shall be exercisable
only by him.

    (f)  EFFECT OF TERMINATION OF EMPLOYMENT.  If a recipient's employment 
(or service as an officer, director or consultant) shall terminate for any 
reason, other than death or Retirement, the right of the recipient to 
exercise any option otherwise exercisable on the date of such termination 
shall expire unless such right is exercised within a period of three months 
after the date of such termination. The term "Retirement" shall mean the 
voluntary termination of employment (or service as an officer, director or 
consultant) by a recipient who has attained the age of 55 and who has at 
least five years service with the Company.  If a recipient's employment (or 
service as an officer, director or consultant) shall terminate because of 
death or Retirement, the right of the recipient to exercise any option 
otherwise exercisable on the date of such termination shall be unaffected by 
such termination and shall continue until the normal expiration of such 
option. Notwithstanding the foregoing, the tax treatment available pursuant 
to Section 422 of the Code upon the exercise of an incentive stock option 
will not be available to a recipient who exercises any incentive stock option 
more than (i) 12 months after the date of termination of employment due to 
death or (ii) three months after the date of termination of employment due to 
Retirement.  Option rights shall not be affected by any change of




employment as long as the recipient continues to be employed by either the 
Company or a parent or subsidiary of the Company. In no event, however, shall 
an option be exercisable after the expiration of its original term as 
determined by the Committee pursuant to subparagraph 6(c) above. The 
Committee may, if it determines that to do so would be in the Company's best 
interests, provide in a specific case or cases for the exercise of options 
which would otherwise terminate upon termination of employment with the 
Company for any reason, upon such terms and conditions as the Committee 
determines to be appropriate, nothing in the Plan or in any option agreement 
shall confer any right to continue in the employ of the Company or any parent 
or subsidiary of the Company or interfere in any way with the right of the 
Company or any parent or subsidiary of the Company to terminate the 
employment of a recipient at any time.

    (g)  LEAVE OF ABSENCE. In the case of a recipient on an approved leave of 
absence, the Committee may, if it determines that to do so would be in the 
best interests of the Company, provide in a specific case for continuation of 
options during such leave of absence, such continuation to be on such terms 
and conditions as the Committee determines to be appropriate, except that in 
no event shall an option be exercisable after 10 years from the date it is 
granted.

    (h)  RECAPITALIZATION. In the event the Committee in its discretion 
determines that any stock dividends, extraordinary cash dividends, creation 
of a class of equity securities, recapitalization, reorganization, merger, 
consolidation, split-up, spin-off, combination, exchange of shares, warrants 
or rights offering to purchase Common Stock at a price substantially below 
fair market value, or other similar transaction affects the Common Stock such 
that an adjustment is required in order to preserve the benefits or potential 
benefits intended to be made available under the Plan, then the Committee 
(subject, in the case of Incentive Stock Options, to any limitation required 
under the Code) shall equitably adjust any or all of (i) the number of shares 
available under the Plan, (ii) the number of shares deliverable upon the 
exercise of any outstanding options granted under the Plan and (ii) the net 
exercise price with respect to any outstanding options.

    (i)  SALE OR REORGANIZATION.  In case the Company is merged or 
consolidated with another corporation, or in case the property of stock of 
the Company is acquired by another corporation, or in case of a separation, 
reorganization, or liquidation of the Company, the Board of Directors of the 
Company, or the board of directors of any corporation assuming the 
obligations of the Company hereunder, shall either (i) make appropriate 
provisions for the Protection of any outstanding options by the-substitution 
on an equitable basis of appropriate stock of the Company, or appropriate 
stock of the merged, consolidated, or otherwise reorganized corporation, 
provided only that such substitution of options shall, with respect to 
incentive stock options, comply with the requirements of Section 425 of the 
Code, or (ii) give written notice to optionees that their options must be 
exercised within 30 days of the date of such notice or they will be 
terminated, and in connection with such notice, the Committee may in its 
discretion accelerate or waive any waiting period. 

    (j)  GENERAL RESTRICTIONS.  Each option granted under the Plan shall be 
subject to the requirement that, if at any time the Board of Directors shall 
determine, in its discretion, that the listing, registration, or 
qualification of the shares issuable or transferable upon exercise thereof 
upon any securities exchange or under any state or federal law, or the 
consent or approval of any governmental regulatory body is necessary or 
desirable as a condition of, or in connection




with, the granting of such option or the issue, transfer, or purchase of 
shares thereunder, such option may not be exercised in whole or in part 
unless such listing, registration, qualification, consent, or approval shall 
have been effected or obtained free of any conditions not acceptable to the 
Board of Directors. 

    The Company shall not be obligated to sell or issue any shares of Common 
Stock in any -manner in contravention of the Securities Act or any state 
securities law. The Board of Directors may, in connection with the granting 
of each option, require the individual to whom the option is to be granted to 
enter into an agreement with the Company stating that as a condition 
precedent to each exercise of the option, in whole or in part, he shall, if 
then required by the Company, represent to the Company in writing that such 
exercise is for investment only and not with a view to distribution, and also 
setting forth such other terms and conditions as the Committee may prescribe. 
Such agreements may also, in the discretion of the Committee, contain 
provisions requiring the forfeiture of any options granted and/or Common 
Stock held, in the event of the termination of employment or association, as 
the case may be, of the optionee with the Company. Upon any forfeiture of 
Common Stock pursuant to any agreement authorized by the preceding sentence, 
the Company shall pay consideration for such Common Stock to the optionee, 
pursuant to any such agreement, without interest thereon. 

    "The Fair Market Value" for all purposes under the Plan shall mean the 
closing price of shares of Common Stock, as reported in the Wall Street 
Journal, by the Nasdaq Stock Market or similar successor consolidated 
transactions reports (or a similar consolidated transactions report for the 
exchange on which the shares of Common Stock are then trading) for the 
relevant date, or if no sales of shares of Common Stock were made on such 
date, the average of the high and low prices of shares as reported in such 
composite transaction report for the preceding day on which sales of shares 
were made. If the shares are not listed on a national securities exchange or 
by the Nasdaq Stock Market at the time Fair Market Value is to be determined, 
then Fair Market Value shall be determined by the Committee in good faith 
pursuant to such method as the Committee deems appropriate and equitable. 
Under no circumstances shall the Fair Market Value of a share of Common Stock 
be less than its par value. 

7.  TERMINATION AND AMENDMENT OF THE PLAN

    The Board of Directors shall have the right to amend, suspend, or 
terminate the Plan at any time: provided, however, that no such action shall 
affect or in any way impair the rights of a recipient under any option right 
theretofore granted under the Plan; and, provided, further, that unless first 
duly approved by the stockholders of the Company entitled to vote thereon at 
a meeting (which may be the annual meeting) duly called and held for such 
purpose, except as provided in subparagraphs 6(h) and 6(i), no amendment or 
change shall be made in the Plan: (a) increasing the total number of shares 
which may be issued or transferred under the Plan; (b) extending the period 
during which options may be granted or exercised under the Plan; or (c) 
changing the designation of persons eligible to receive options under the 
Plan.




8.  NOTICE OF SALE OF SHARES REQUIRED

    The optionee agrees to notify the Company in writing within thirty (30) 
days of the disposition of one or more shares of stock which were transferred 
to such optionee pursuant to the exercise of an incentive stock option 
granted under this Plan if such disposition occurs within two years of the 
date of grant of the option or within one year after the exercise of the 
option. 

9.  EFFECTIVE DATE OF THE PLAN

    This Plan shall become effective December 17, 1993, subject, however, to 
approval by the stockholders of the Company within 12 months next following 
adoption by the Board of Directors; and if such approval is not obtained, the 
Plan shall terminate and any and all options granted during such interim 
period shall also terminate and be of no further force or effect. The Plan 
shall, in all events, terminate on the tenth anniversary of the effective 
date of the Plan, or on such earlier date as the Board of Directors of the 
Company may determine.  Any option outstanding at the termination date shall 
remain outstanding until it has either expired or has been exercised.

10. COMPLIANCE WITH RULE 16b-3
 
    With respect to persons subject to Section 16 of the Exchange Act, 
transactions under this Plan are intended to comply with all applicable 
conditions of Rule 16b-3 or its successors.  To the extent any provision of 
the Plan or action by the Committee (or any other person on behalf of the 
Committee or the Company) fails to so comply, it shall be deemed null and 
void, to the extent permitted by law and deemed advisable by the Committee.