SEPARATION AGREEMENT AND MUTUAL RELEASE

    This Agreement, dated as of September 18, 1996 ("Effective Date"), is 
between Metra Biosystems, Inc., a California corporation ("Metra"), and 
Colette Z. Andrea ("Andrea").

                                   RECITALS

    Andrea desires to resign her employment with Metra effective as of 
September 18, 1996 ("Resignation Date"), and Metra is willing to accept 
Andrea's resignation.

    Metra desires to retain Andrea's services as a consultant and Andrea is 
willing to serve as a consultant under the conditions described herein.

    Metra and Andrea desire to resolve all claims as described in this 
Agreement and thereby avoid the expense and uncertainty of litigation.

    ACCORDINGLY, the parties agree as follows:

    1.   METRA'S OBLIGATIONS.  In consideration for Andrea's voluntary 
resignation and the other obligations described below, Metra agrees to 
provide Andrea the following severance benefits:

         (A)  SEVERANCE AND CONSULTING PAYMENTS.  For the lesser of (a) 
    until March 18, 1997, or (b) until Andrea becomes employed at another 
    employer (defined as the "Initial Severance Period"), Metra agrees to pay 
    Andrea, semi-monthly and in accordance with the Company's normal payroll 
    practices Seven Thousand Five Hundred Dollars ($7,500), less applicable 
    withholdings and any amounts earned by Andrea through consulting activities 
    she provides to other entities.  In the event that Andrea becomes employed 
    at another employer prior to March 18, 1997, Metra agrees to pay Andrea as 
    a lump sum, less applicable withholdings, any remaining payments owed Andrea
    during the Initial Severance Period (E.G., if Andrea is employed at three 
    (3) months, the remaining three (3) months of pay in lump sum, which would 
    be $45,000, less the same withholdings that apply for any employee as 
    required by law, will be provided to Andrea.)

         If Andrea remains unemployed at the conclusion of the Initial
    Severance Period, and has made good faith efforts to seek reemployment,
    Metra agrees to continue these payments for the lesser of (a) until
    September 18, 1997, or (b) until Andrea becomes employed at another employer
    (defined as the "Extended Severance Period").  "Good faith" is defined as 
    the steps necessary for a reasonable person in Andrea's position at Metra 
    prior to the date of resignation hereunder to secure comparable employment 
    in Northern California.  "Employment" is defined as a full-time, 
    nonconsulting position, with an annual salary not less than $160,000.00.


                                         1




         Should Andrea become either physically or mentally disabled such that
    she cannot be employed, or if Andrea sustains death, the obligations of
    Metra will not cease under this Agreement, and the terms and conditions of
    the agreement will inure to the benefit of Andrea's family, husband and
    children.

         (B)  BENEFITS CONTINUATION.  Metra will provide Andrea and her
    dependents with the medical and dental benefits required by the
    Consolidated Omnibus Budget Reconciliation Act of 1985 ("COBRA").  In the
    provision of these benefits, Metra agrees to pay Andrea's COBRA premiums,
    less her current family copayment for coverage as Andrea and all executives
    now make, through September 18, 1997, or until Andrea becomes eligible for 
    coverage under another plan (the "Benefits Continuation Period"). Following 
    the Benefits Continuation Period, Metra shall continue to provide COBRA 
    benefits as required by law, with Andrea to pay the COBRA premiums.

         (C)  CONTINUED STOCK VESTING.  Subject to Andrea's continued
    eligibility to receive the severance and consulting payments described in
    Paragraph 1(a) above, and subject to her continued adherence to the
    noncompetition obligations set forth in paragraph 2(e) below, Andrea will
    continue to vest in common stock Andrea received under the
    December 30, 1994 stock grant.  However, Metra agrees that, should Andrea
    become reemployed during the Initial Severance Period, she, nonetheless,
    will be permitted to continue to vest in the common stock she received
    under the December 30, 1994 stock grant until March 18, 1997.

         (D)  OUTSTANDING AMOUNTS OWED FOR HOUSING LOAN AND RELOCATION
    EXPENSES.  Any amounts owed by Andrea to Metra arising from Andrea's
    housing loan or relocation expenses will be written off by Metra.

         (E)  INDEMNIFICATION.  Metra agrees to indemnify Andrea for any fees,
    costs and penalties if Andrea is named as a party or is threatened to be
    made a party to any threatened, pending or completed action, suit or
    proceeding, whether civil, criminal, administrative or investigative by
    reason of the fact that Andrea was an officer, employee or agent of Metra
    or based upon any action or inaction undertaken by Andrea while exercising
    her duties and responsibilities on behalf of Metra.  In this regard, Metra
    reaffirms its obligations to Andrea under the Metra Biosystems
    Indemnification Agreement the parties executed on September 26, 1994.

         (F)  REFERENCE LETTERS.  Metra agrees that Mr. George Dunbar and
    Mr. Ronald Steckel will provide Andrea with mutually-acceptable letters of
    reference (attached).

         (G)  PRESS RELEASE.   Prior to publishing a press release describing
    Andrea's resignation from the Company, Metra will share with Andrea the
    contents of any release in which her resignation is described.  The
    release, to the extent that it shall refer, either directly or indirectly,
    to Andrea shall be approved and/or edited by Andrea prior to its
    publication.


                                     2




    2.   ANDREA'S OBLIGATIONS.

         (A)  RESIGNATION.  Andrea resigns her employment with Metra effective
    as of September 18, 1996.

         (B)  NOTICE OF REEMPLOYMENT.  During the Initial and Extended
    Severance Periods, Andrea shall provide Metra advance written notice of
    (i) the effective date of any subsequent employment, and (ii) the effective
    date of her eligibility under any applicable benefit plan with another
    employer.

         (C)  NOTICE OF CONSULTANTSHIP INCOME AND REEMPLOYMENT EFFORTS.  Andrea
    agrees that throughout the severance continuation period, she will report,
    in writing and on a semi-monthly basis, to Debby Dean at Metra, all income
    she earns as a consultant or an employee from entities other than Metra
    and, further, understands that such income shall be deducted from the
    severance payments described in Paragraph 1(a) above.

         Andrea also agrees that she will report to Ms. Dean, in writing every
    ninety days, the number of all prospective employers and search firms that
    Andrea has contacted with respect to her efforts to seek reemployment.

         (D)  SERVICE AS CONSULTANT TO METRA.  During the severance period,
    Andrea agrees to serve as a consultant to Metra, and will provide
    consulting services, as required by the Company, not to exceed six hours
    per month.

         (E)  NONCOMPETITION.  During the period Andrea receives severance
    benefits under Paragraph 1(a) above, Andrea agrees that she will not work
    for, as either an employee or a consultant, any of the following companies: 
    (1) DSL; (2) Inc Star; (3) Osteometer; (4) Ostex International; (5) The 
    Nichols Institute; (6) Lunar; (7) Norland; and (8) Hologic.  If Andrea 
    accepts employment with, or provides consulting services for, the entities 
    listed above, all severance payments, benefits continuanceand stock vesting 
    under this Agreement will cease.

         (F)  COOPERATION.  Andrea shall cooperate with Metra in (i)  the
    orderly transfer of Andrea's responsibilities to other person(s); (ii) the
    defense of any action brought by any third party against Metra that relates
    in any way to Andrea's acts or omissions while employed by Metra; and
    (iii) the prompt return to Metra of all property of Metra, including,
    without limitation, her building access card and keys, all equipment,
    tangible proprietary information, documents, books, records, reports,
    contracts, lists, computer disks (or other computer-generated files or
    data), or copies thereof, created on any medium, prepared or obtained by
    Andrea in the course of or incident to her employment with Metra.


                                      3



         (G)  CONFIDENTIAL INFORMATION.  Andrea shall not, for the benefit of
    any person or entity other than Metra, disclose or use any information
    regarding Metra' business, employees, or customers, which was produced by
    any employee of Metra in the course of his or her employment or otherwise
    produced or acquired by or on behalf of Metra, and which is not properly in
    the public domain.

         Andrea further acknowledges that she remains bound by the obligations
    set forth in the Non-Disclosure Agreement between the parties, dated
    July 7, 1994, and in the Employee Confidentiality and Inventions Agreement
    that she executed on December 10, 1994.

    3.   ACKNOWLEDGMENT THAT NO OTHER COMPENSATION DUE ANDREA.  Andrea
expressly acknowledges that the payments and benefits described in Paragraph 1
above, include consideration beyond that to which Andrea is otherwise entitled
and all compensation due Andrea by Metra, including all wages, commissions,
bonus payments, and payments for accrued but unused vacation and stock options.

    4.   MUTUAL RELEASE.  

         (A)  RELEASE BY ANDREA.  Except for Metra's continuing obligations
    under this Agreement, Andrea and her representatives, heirs, successors,
    and assigns do hereby completely release and forever discharge Metra, any
    Affiliate, and its and their present and former shareholders, officers,
    directors, agents, employees, attorneys, successors, and assigns
    (collectively, "Released Parties") from all claims, rights, demands,
    actions, obligations, liabilities, and causes of action of every kind and
    character, known or unknown, mature or unmatured, which Andrea may now have
    or has ever had, arising out of Andrea's employment at Metra as prior to
    the date of her resignation from Metra, whether based on tort, contract
    (express or implied), or any federal, state, or local law, statute, or
    regulation (collectively, the "Released Claims").  By way of example and
    not in limitation of the foregoing, Released Claims shall include any
    claims arising under Title VII of the Civil Rights Act of 1964, the Age
    Discrimination in Employment Act, the Americans with Disabilities Act, and
    the California Fair Employment and Housing Act, as well as any claims
    asserting wrongful termination, breach of contract, breach of the covenant
    of good faith and fair dealing, negligent or intentional infliction of
    emotional distress, negligent or intentional misrepresentation, negligent
    or intentional interference with contract or prospective economic
    advantage, defamation, invasion of privacy, and claims related to
    disability.  Released Claims shall also include, but not be limited to,
    claims for severance pay, bonuses, sick leave, vacation pay, life or health
    insurance, or any other fringe benefit.  Andrea likewise releases the
    Released Parties from any and all obligations for attorneys' fees incurred
    in regard to the above claims or otherwise.  Notwithstanding the foregoing,
    Released Claims shall not include any claims based on obligations created
    by or reaffirmed in this Agreement.

                                     4



         (B)  RELEASE BY METRA.  Except for Andrea's continuing obligations
    under this Agreement, Metra, any Affiliate, and its and their present and
    former shareholders, officers, directors, agents, employees, attorneys,
    successors, and assigns (referred to hereinafter collectively as "Metra")
    do hereby completely release and forever discharge Andrea, and her
    representatives, heirs, successors, and assigns from all claims, rights,
    demands, actions, liabilities, causes of action, and obligations of any
    kind and character whatsoever, whether known or unknown, matured or
    unmatured, suspected or unsuspected, which Metra may now have or has ever
    had against Andrea from the beginning of time through the date Metra and
    Andrea executed this Agreement (collectively, the "Released Claims"). 

    5.   SECTION 1542 WAIVER.  The parties understand and agree that the
Released Claims include not only claims presently known to Andrea and/or Metra,
but also include all unknown or unanticipated claims, rights, demands, actions,
obligations, liabilities, and causes of action of every kind and character that
would otherwise come within the scope of the Released Claims as described in
Section 4.  Andrea and Metra understand that they may hereafter discover facts
different from what they now believe to be true which, if known, could have
materially affected this Agreement, but they, nevertheless, waive any claims or
rights based on different or additional facts.  Andrea and Metra knowingly and
voluntarily waive any and all rights or benefits that they may now have, or in
the future may have, under the terms of Section 1542 of the California Civil
Code, which provides as follows:

         A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES
         NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF EXECUTING THE
         RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY AFFECTED HIS
         SETTLEMENT WITH THE DEBTOR.

    6.   MUTUAL NONDISPARAGEMENT.  Both Andrea and Metra's senior management,
as well as Metra's Board of Directors, agree that both Andrea and Metra's senior
management, as well as Metra's Board of Directors (both present and future)
shall not make or publish, either orally or in writing, any disparaging
statements regarding Andrea or Metra or Metra's senior management, or in any way
impede or interfere with the contracts or customer relationships of the other. 
Metra will not authorize, ratify or condone any disparaging statements by any
other of its employees, agents, representatives of any type.

    7    COVENANT NOT TO SUE.  The parties shall not sue or initiate against
any Released Party any compliance review, action, or proceeding, or participate
in the same, individually or as a member of a class, under any contract (express
or implied), or any federal, state, or local law, statute, or regulation
pertaining in any manner to the Released Claims.

    8.   CONFIDENTIALITY.  The parties understand and agree that this Agreement
and each of its terms, and the negotiations surrounding it, are confidential and
shall not be disclosed by the other to any entity or person, for any reason, at
any time, without the prior written consent of the other, unless required by
law.  Notwithstanding the foregoing, Andrea may disclose the terms of


                                       5



this Agreement to her spouse, and for legitimate business reasons, to legal, 
financial, and tax advisors.

    9.   AGE DISCRIMINATION CLAIMS.  Andrea understands and agrees that, by
entering into this Agreement, (i) she is waiving any rights or claims she might
have under the Age Discrimination in Employment Act, as amended by the Older
Workers Benefit Protection Act; (ii) she has received consideration beyond that
to which she was previously entitled; (iii) she has been advised to consult with
an attorney before signing this Agreement and has consulted with the Law Office
of Maryanne Zanios Murphy; and (iv) she has been offered the opportunity to
evaluate the terms of this Agreement for not less than twenty-one (21) days
prior to her execution of the Agreement but has voluntarily waived the remainder
of the twenty-one day period.  Andrea may revoke this Agreement (by written
notice to Metra) for a period of seven (7) days after her execution of the
Agreement, and it shall become enforceable only upon the expiration of this
revocation period without prior revocation by Andrea.

    10.  ARBITRATION.  All claims that Andrea may have against Metra or any
other Released Party, or which Metra may have against Andrea, of any kind,
including, but not limited to, all claims in any way related to the subject
matter, interpretation, application, or alleged breach of this Agreement
("Arbitrable Claims") shall be resolved by arbitration.  Arbitrable Claims shall
include, but are not limited to, contract (express or implied) and tort claims
of all kinds, as well as all claims based on any federal, state, or local law,
statute, or regulation, excepting only claims under applicable workers'
compensation law and unemployment insurance claims.  Arbitration shall be final
and binding upon the parties and shall be the exclusive remedy for all
Arbitrable Claims.  Arbitration of Arbitrable Claims shall be in accordance with
the National Rules for the Resolution of Employment Disputes of the American
Arbitration Association, as amended, and as augmented by this Agreement.  Either
party may bring an action in court to compel arbitration under this Agreement
and to enforce an arbitration award.  Otherwise, neither party shall initiate or
prosecute any lawsuit or administrative action in any way related to any
Arbitrable Claim.  The Federal Arbitration Act shall govern the interpretation
and enforcement of this Section.  THE PARTIES HEREBY WAIVE ANY RIGHTS THEY MAY
HAVE TO TRIAL BY JURY IN REGARD TO ARBITRABLE CLAIMS.

    11.  NOTICES.  Any notice under this Agreement must be in writing and shall
be effective upon delivery by hand or three (3) business days after deposit in
the United States mail, postage prepaid, certified or registered, and addressed
to Metra or to Andrea at the corresponding address below.  Andrea shall be
obligated to notify Metra in writing of any change in her address.  Notice of
change of address shall be effective only when done in accordance with this
Section.

                                     6



Metra' Notice Address:

         Metra Biosystems, Inc.
         265 North Whisman Road
         Mountain View, CA 94043

Andrea's Notice Address:

         Colette Z. Andrea
         1531 Chaumont Drive
         San Jose, CA 95118

    12.  INTEGRATION.  The parties understand and agree that the preceding
Sections recite the sole consideration for this Agreement; that no
representation or promise has been made by Andrea, Metra, or any other Released
Party concerning the subject matter of this Agreement, except as expressly set
forth in this Agreement; and that all agreements and understandings between the
parties concerning the subject matter of this Agreement are embodied and
expressed in this Agreement.

    13.  AMENDMENTS; WAIVERS.  This Agreement may not be amended except by an
instrument in writing, signed by each of the parties.  No failure to exercise
and no delay in exercising any right, remedy, or power under this Agreement
shall operate as a waiver thereof, nor shall any single or partial exercise of
any right, remedy, or power under this Agreement preclude any other or further
exercise thereof, or the exercise of any other right, remedy, or power provided
herein or by law or in equity.

    14   ASSIGNMENT; SUCCESSORS AND ASSIGNS.  Andrea agrees that she will not
assign, sell, transfer, delegate, or otherwise dispose of, whether voluntarily
or involuntarily, or by operation of law, any rights or obligations under this
Agreement.  Any such purported assignment, transfer, or delegation shall be null
and void.  Andrea represents that she has not previously assigned or transferred
any claims or rights released by her pursuant to this Agreement.  Subject to the
foregoing, this Agreement shall be binding upon and shall inure to the benefit
of the parties and their respective heirs, successors, attorneys, and permitted
assigns.  This Agreement shall also inure to the benefit of any Released Party. 
This Agreement shall not benefit any other person or entity except as
specifically enumerated in this Agreement.

    15.  SEVERABILITY.  If any provision of this Agreement, or its application
to any person, place, or circumstance, is held by an arbitrator or a court of
competent jurisdiction to be invalid, unenforceable, or void, such provision
shall be enforced to the greatest extent permitted by law, and the remainder of
this Agreement and such provision as applied to other persons, places, and
circumstances shall remain in full force and effect.

    16.  ATTORNEYS' FEES.  In any legal action, arbitration, or other
proceeding brought to enforce or interpret the terms of this Agreement, the
prevailing party shall be entitled to recover reasonable attorneys' fees and
costs.


                                      7


    17.  GOVERNING LAW.  This Agreement shall be governed by and construed in
accordance with the law of the State of California.

    18.  REPRESENTATION BY COUNSEL.  The parties acknowledge that (i) they have
consulted counsel in regard to this Agreement; (ii) they have read and
understand the Agreement and they are fully aware of its legal effect; and (iii)
they are entering into this Agreement freely and voluntarily, and based on each
party's own judgment and not on any representations or promises made by the
other party, other than those contained in this Agreement.

    19.  AUTHORIZATION.  Each of the parties has executed this Agreement, in
the case of Metra by its duly authorized officer, as of the day and year first
written above.


                               /s/  Colette Z. Andrea
                       -----------------------------------------
                                   Colette Z. Andrea
    
    
    
                                METRA BIOSYSTEMS, INC.
    

                                /s/  George W. Dunbar
                       -----------------------------------------
                                   George W. Dunbar
                         President and Chief Executive Officer




September 18, 1996


To Whom It May Concern:

Colette was hired by Metra in September 1994 as Vice President of Marketing 
and Clinical Affairs. Her extensive experience in pharmaceutical marketing 
was attractive to us as we set about introducing a new diagnostic marker 
which complements hormone replacement therapy products.

While somewhat unusual to include marketing, Colette was invited to join 
Metra's road show team when the Company sought its initial public offering 
in June 1995. She proved to be a good presenter and was able to effectively 
respond to investor questions. She continued to be a regular marketing 
contact with Metra's investment community.

Colette assumed responsibility for the Americas Sales function in January 
1996, relinquishing Clinical Affairs at that time.

Colette is dynamic, competitive and has a high energy level. Colette is a 
strong strategic planner. She has been innovative in developing our launch 
plans. Her confidence and best efforts show when she is in the medical 
education role where she utilizes the strongest components of her technical, 
marketing and sales experiences and strengths.

Colette will certainly make a dynamic and visible contribution to any 
employer.

Sincerely,


/s/ George Dunbar

George Dunbar
President and CEO



September 18, 1996


To whom it may concern:

Over the past two years, I have worked with Colette Andrea in her initial 
role as Metra's Vice President of Marketing and Clinical Affairs and later as 
Vice President Marketing and U.S. Sales.

Colette brought a great deal of experience in pharmaceutical marketing to 
Metra. She exhibits a high degree of professionalism, a toughness in the face 
of difficult circumstances, and an intense desire to succeed. Colette pursued 
a tireless path including a rigorous travel schedule to help create market 
awareness for Metra's novel biochemical markers.

Colette took personal time to develop mentoring relationships with two 
employees within my group.

Colette will surely bring these same strengths to another employer.

Sincerely,

/s/ Ronald T. Steckel

Ronald T. Steckel
Senior Vice President