EXHIBIT 3.02

                                 STATE OF DELAWARE


                                    [SEAL]


                           OFFICE OF SECRETARY OF STATE

                               ------------------

     I, MICHAEL HARKINS, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY 
CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE CERTIFICATE OF 
AMENDMENT OF "CHIRON CORPORATION" FILED IN THIS OFFICE ON THE TWELFTH DAY OF 
DECEMBER, A.D. 1991, AT 11:24 O'CLOCK A.M.

                              * * * * * * * * * * *




[SEAL]

                                            /s/Michael Harkins
                                            -----------------------------------
                                            Michael Harkins, Secretary of State

                                            AUTHENTICATION: #3267833

                                                      DATE: 12/12/1991






                           CERTIFICATE OF AMENDMENT
                                       OF 
                     RESTATED CERTIFICATE OF INCORPORATION

     CHIRON CORPORATION, a corporation organized and existing under and by 
virtue of the General Corporation Law of the State of Delaware,

     DOES HEREBY CERTIFY:

     FIRST: That at a meeting of the Board of Directors of CHIRON 
CORPORATION, resolutions were duly adopted setting forth a proposed amendment 
of the Restated Certificate of Incorporation of said corporation, declaring 
said amendment to be advisable and calling a meeting of the stockholders of 
said corporation for consideration thereof. The resolution setting forth the 
proposed amendment is as follows:

     RESOLVED, that the Restated Certificate of Incorporation of this 
corporation be amended by changing the Article thereof numbered "FIFTH" so 
that, as amended, said Article shall be and read as follows:

     "FIFTH: This corporation is authorized to issue two classes of shares to 
be designated, respectively, `Preferred Stock' and `common stock.' The total 
number of shares which this corporation is authorized to issue is one hundred 
five million (105,000,000). Five million (5,000,000) shares shall be 
Preferred Stock and one hundred million (100,000,000) shares shall be common 
stock. The Preferred Stock shall have a par value of $0.01 per share; the 
common stock shall have a par value of $0.01 per share.

     1.    PREFERRED STOCK.

           The Preferred Stock may be issued from time to time in one or more 
      series. The Board of Directors is expressly authorized, in the 
      resolution or resolutions providing for the issuance of any wholly 
      unissued series of Preferred Stock, to fix, state and express the 
      powers, rights, designations, preferences, qualifications, limitations 
      and restrictions thereof, including without limitation: the rate of 
      dividends upon which and the times at which dividends of shares of such 
      series shall be payable and the preference, if any, which such 
      dividends shall have relative to dividends on shares of any other class 
      or classes or any other series of stock of the corporation; whether 
      such dividends shall be cumulative or noncumulative, and if cumulative, 
      the date or dates from which dividends on shares of such series shall 
      be cumulative; the voting rights, if any, to be provided for shares of 
      such series: the rights, if any, which the holders of shares of such 
      series shall have in the event of any voluntary or involuntary 
      liquidation, dissolution or winding up of the affairs of the 
      corporation; the rights, if any, which the holders of shares of such 
      series shall have to convert such shares into or exchange such shares 
      for shares of stock of the corporation, and the terms and conditions, 
      including price and rate of exchange of such conversion or 



      exchange; and the redemption rights (including sinking fund provisions), 
      if any, for shares of such series; and such other powers, rights, 
      designations, preferences, qualifications, limitations and restrictions 
      as the Board of Directors may desire to so fix. The Board of Directors 
      is also expressly authorized to fix the number of shares constituting 
      such series and to increase or decrease the number of shares of any 
      series prior to the issuance of shares of that series and to increase 
      or decrease the number of shares of any series subsequent to the 
      issuance of shares of that series, but not to decrease such number 
      below the number of shares outstanding. In case the number of shares of 
      any series shall be so decreased, the shares constituting such decrease 
      shall resume the status which they had prior to the adoption of the 
      resolution originally fixing the number of shares of such series.

     2.    COMMON STOCK.

          The common stock may be issued from time to time in one or more 
     series. Ninety-nine million five hundred thousand (99,500,000) shares of
     common stock are designated `Common Stock.' All other series of common
     stock shall collectively consist of five hundred thousand (500,000) shares
     and shall be designated, as a group, `Restricted Common Stock.'

     3.    RESTRICTED COMMON STOCK.

           (a)  AUTHORITY OF BOARD TO FIX RIGHTS OF RESTRICTED COMMON STOCK.  
     The Board of Directors is expressly authorized, in the resolution or 
     resolutions providing for the issuance of any wholly unissued series of 
     Restricted Common Stock, to fix, state and express, within the limits 
     expressed hereinbelow, the powers, designations, preferences and rights 
     of the Restricted Common Stock, and the qualifications, limitations or 
     restrictions thereof. The Board of Directors is also expressly 
     authorized to fix the number of shares constituting such series and to 
     increase or decrease the number of shares of any series prior to the 
     issuance of shares of that series and to increase or decrease the number 
     of shares of any series subsequent to the issue of shares of that 
     series, but not to decrease such number below the number of such series 
     then outstanding. In case the number of shares of any series shall be so 
     decreased, the shares constituting such decrease shall resume the status 
     which they had prior to the adoption of the resolution originally fixing 
     the number of shares of such series.

           (b)  SPECIFIC RIGHTS. The rights, preferences, privileges and   
     restrictions of the Common Stock and Restricted Common Stock shall be 
     identical in all respects, except as follows, or, for the Restricted 
     Common Stock, as fixed and determined by the Board of Directors within 
     the limitations which follow:

                i)   CONVERSION RIGHTS. The Restricted Common Stock may be  
     convertible into or exchangeable for Common Stock, at a conversion or

                                      2.



     exchange ratio of not more than one share of Common Stock for each share 
     of Restricted Common Stock and upon such other terms and conditions as 
     the Board of Directors may establish.

                ii)  VOTING RIGHTS. Subject to the special voting rights (if 
     any) of the Preferred Stock set forth or determined as provided in 
     this Article FIFTH, each holder of Common Stock of this corporation 
     shall be entitled to one vote for each share of such stock outstanding 
     in the name of such holder on the books of this corporation on the 
     record date designated for the purpose of such vote, and each holder of 
     Restricted Common Stock of the corporation shall be entitled, for each 
     share of such Restricted Common Stock outstanding in the name of such 
     holder on the books of the corporation on the record date designated for 
     the purpose of such vote, to the number of votes as has been fixed by 
     the Board of Directors, but the vote per share of Restricted Common 
     Stock shall not be more than the proportionate vote of the Common Stock 
     into which such Restricted Common Stock is convertible or exchangeable.

                iii) DIVIDEND RIGHTS. Subject to the prior rights (if any)    
     of the holders of the Preferred Stock as to dividends, the holders of 
     outstanding shares of Common Stock and Restricted Common Stock shall be 
     entitled to receive, when and as declared by the Board of Directors, out 
     of the assets of the corporation at the time legally available therefor, 
     dividends at the rate determined by the Board of Directors: provided, 
     however, that the dividend on each share of Restricted Common Stock 
     shall be less than the proportionate dividend on each share of Common 
     Stock into which it is convertible or exchangeable.

                iv)  LIQUIDATION RIGHTS. In the event of any liquidation,     
      dissolution or winding up of this corporation either voluntarily or 
     involuntarily, but subject to the liquidation preference (if any) of the 
     holders of Preferred Stock by reason of their ownership thereof, the 
     holders of Common Stock and Restricted Common Stock shall be entitled to 
     receive pro rata the remaining assets of the corporation available for 
     distribution to shareholders except that the amounts per share paid in 
     liquidation on each share of Restricted Common Stock shall be less than 
     the proportionate amount per share paid on each share of the Common 
     Stock into which it is convertible or exchangeable.

                v)   ADJUSTMENTS. The Board of Directors shall make 
     appropriate adjustments to the conversion or exchange ratio and to 
     the voting, dividend and liquidation rights of the Restricted Common 
     Stock in the event of any stock split, stock dividend or similar 
     transaction affecting the number of outstanding shares of Common Stock 
     or Restricted Common Stock without the corporation's receipt of 
     consideration thereof."

                                     3.



     SECOND: That thereafter, pursuant to resolution of its Board of 
Directors, a special meeting of the stockholders of said corporation was duly 
called and held, upon notice in accordance with Section 222 of the General 
Corporation Law of the State of Delaware at which meeting the necessary 
number of shares as required by statute were voted in favor of the amendment.

     THIRD: That said amendment was duly adopted in accordance with the 
provisions of Section 242 of the General Corporation Law of the State of 
Delaware.

     IN WITNESS WHEREOF, said CHIRON CORPORATION has caused this certificate 
to be signed by EDWARD E. PENHOET, its Vice Chairman of the Board of 
Directors and Chief Executive Officer, and attested by WILLIAM G. GREEN, its 
Secretary, this 12th day of December, 1991.



                                               By  /s/Edward E. Penhoet
                                                   --------------------------
                                                   Edward E. Penhoet
                                                   Vice Chairman and
                                                   Chief Executive Officer


(SEAL)

Attest: /s/William G. Green
       --------------------------------
           William G. Green, Secretary