SECURED PROMISSORY NOTE

$80,000                                                 Boston, Massachusetts
                                                        May 19, 1997

    FOR VALUE RECEIVED, the undersigned, Mark P. Carthy (the "Maker"), by 
this Secured Promissory Note (this "Note"), absolutely and unconditionally 
promises to pay to the order of CUBIST PHARMACEUTICALS, INC., a Delaware 
corporation (the "Payee"), the aggregate principal amount of Eighty Thousand 
Dollars ($80,000) on May 18, 2000 (the "Maturity Date"), and to pay interest 
on the principal amount outstanding from time to time hereunder, from the 
date hereof through and including the date on which such principal amount is 
paid in full, at a rate of four percent (4%) per annum simple interest. 
Interest hereunder shall be due and payable on the first anniversary hereof 
and on the Maturity Date or any accelerated maturity hereof.

    The Maker shall have the right to prepay the unpaid principal amount of 
this Note in full at any time, or in part from time to time, without premium 
or prepayment penalty, provided that there is paid with each such principal 
prepayment all accrued and unpaid interest to the date of prepayment 
(calculated on the basis of a 365-day year for the actual number of days for 
which the same is due).

    All payments of interest and principal hereunder shall be made at the 
principal residence or business address of the holder hereof. All payments 
hereunder shall be applied first to any unpaid accrued interest, second to 
payment of all, if any, other amounts except principal due under or in 
respect of this Note, and third to repayment of principal.

    This Note is made and delivered by the Maker to the Payee pursuant to 
that certain letter agreement, dated as of the date hereof, among the Payee 
and the Maker, and is secured pursuant to the provisions of a certain Stock 
Pledge Agreement, dated of even date herewith, between the Maker and the 
Payee.

    Anything implied herein to the contrary notwithstanding, in the event 
that (1) the Maker shall fail to pay when due all or any portion of the 
principal of or interest on this Note, (2) the Maker shall make an assignment 
of the whole or a substantial part of his assets for the benefit of 
creditors, or (3) there shall be commenced by or against the Maker any 
proceeding under any bankruptcy, insolvency, readjustment of debt or similar 
law of any jurisdiction, (each event referred to in clauses (1) through (3) 
above being hereinafter referred to herein as an "Event of Default") then 
without notice to or demand upon the Maker the entire unpaid principal of 
this Note, and all interest accrued thereon, shall (if not already due and 
payable) immediately become and be due and payable to the order of the holder 
hereof.




                                       -2-

    The Maker hereby, to the fullest extent permitted by applicable law: (a) 
waives presentment, demand, notice, protest, and all other demands and 
notices in connection with delivery, acceptance, performance, default, 
acceleration or enforcement of or under this Note; (b) assents to any 
extension or postponement of the time of payment or any other indulgence, and 
to any substitution, exchange or release of collateral; and (c) agrees to pay 
to the holder, on demand, all costs and expenses of collection, including, 
without limitation, reasonable attorneys' fees and legal expenses, incurred 
by the holder in enforcing this Note, whether or not litigation is commenced.

    No failure by the holder to exercise, or delay by the holder in 
exercising, any right or remedy hereunder shall operate as a waiver thereof, 
or of any other right or remedy, and no single or partial exercise of any 
right or remedy shall preclude any other or further exercise thereof or of 
any other right or remedy. Acceptance by the holder of any payment after the 
maturity of this Note has been accelerated shall not constitute a waiver of 
such acceleration.

    This Note shall take effect as an instrument under seal and shall be 
governed by and construed in accordance with the law of The Commonwealth of 
Massachusetts.

                                       /s/ Mark P. Carthy
                                       --------------------------------------
                                       Mark P. Carthy
                                       21 Stone Road
                                       Belmont, MA 02178