ONYX PHARMACEUTICALS, INC. Exhibit 11.1 COMPUTATION OF NET LOSS PER SHARE (In thousands, except per share amounts) (unaudited) Three Months Ended Six Months Ended June 30, June 30, -------------------- -------------------- 1997 1996 1997 1996 --------- --------- --------- --------- NET LOSS: $ (3,758) $ (2,367) $ (6,251) $ (4,660) --------- --------- --------- --------- --------- --------- --------- --------- Shares used in net loss per share computation: Weighted average shares of common stock outstanding: 9,680 5,814 9,602 3,395 Shares related to Staff Accounting Bulletins Nos. 55, 64 and 83 - - - 213 --------- --------- --------- --------- Shares used in net loss per share computation: 9,680 5,814 9,602 3,608 --------- --------- --------- --------- --------- --------- --------- --------- Net loss per share $ (0.39) $ (0.41) $ (0.65) $ (1.29) --------- --------- --------- --------- --------- --------- --------- --------- CALCULATION OF SHARES OUTSTANDING FOR COMPUTING PRO FORMA NET LOSS PER SHARE: Shares used in computing historical net loss per share (from above): 5,814 3,608 Adjusted to reflect the effect of the assumed conversion of convertible preferred stock from the date of issuance: 2,260 3,750 --------- --------- Shares used in computing pro forma net loss per share: 8,074 7,358 --------- --------- --------- --------- Pro forma net loss per share $ (0.29) $ (0.63) --------- --------- --------- ---------