Exhibit 10.29

September 14, 1999




Leonard Bell, M.D.
59 Tumblebrook Road
Woodbridge, Connecticut 06525


     Re:   Amendments to the Employment Agreement, dated as of April 1, 1997,
           by and between Alexion Pharmaceuticals, Inc. (the "Company") and
           Leonard Bell (The "Executive" or "Optionee") and the Stock Option
           Agreement, dated as of July 29, 1998, by and between the Company
           and the Optionee


Dear Dr. Bell

    I.     With reference to the Employment Agreement, dated as of April 1,
1997, by and between the Company and the Executive (the "Employment
Agreement"), please execute the signature line below to confirm our
understanding as follows:

    1.     Section 9 of the Employment Agreement shall hereinafter be
           referred to as Section 9(a); and

    2.     The following paragraph shall be added as Section 9(b) of the
           Employment Agreement:

               (b)   If (i) the Company has not on or prior to sixty days
           before the expiration of the Term of the Agreement (except for any
           termination pursuant to Section 7(a)(3), 7(a)(4) or 7(b), offered
           to enter into a new employment agreement with Executive on
           substantially the same terms as the Current Employment Agreement
           or on terms more favorable to the Executive, which offer shall not
           have been revoked at any time prior to such expiration or (ii) upon
           the expiration or termination of the agreement (except for any
           termination pursuant to Section 7(a)(3), 7(a)(4) or 7(b), the
           parties have not entered into a new employment agreement on
           substantially the same terms as the Agreement or on terms more
           favorable to the Executive, or (iii) the Executive is unable to
           continue his employment/service due to his death or unable to
           continue his employment


           and perform his duties due to physical or mental incapacity or
           disability, with or without reasonable accommodation, in accordance
           with applicable law, for a period of six months or more, all stock
           options and stock awards (and similar equity rights), held by the
           Executive prior to his death/disability, or the expiration or
           termination of the Agreement, shall vest and become immediately
           exercisable and remain exercisable through their original terms
           with all rights. This Section 9(b) shall survive the expiration or
           termination pursuant to Section 7(a)(3), 7(a)(4) or 7(b).

    II.    With reference to the Stock Option Agreement, dated as of July 29,
1998, by and between the Company and the Optionee (the "Stock
Option Agreement"), please execute the signature line to below to onfirm our
understanding as follows:

    1.     The first paragraph (and table included therein) of Section 3 of
           the Stock Option Agreement is hereby amended to read in its
           entirety as follows:

                3.  EXERCISE. Provided that the Optionee shall be in the
           employ or service (as an officer, director, consultant or other
           independent contractor or otherwise) by the Company or a subsidiary,
           the Option to purchase 60,000 shares of Common Stock shall become
           exercisable, subject to acceleration of such vesting as herein
           provided and as provided in that certain Employment Agreement
           between the Company and the Optionee, in effect from time to time,
           in accordance with the following schedule:


           Event Relating To Vesting                       Cumulative Percentage Of Option Exercisable
           -------------------------                       -------------------------------------------
                                                  
           If Optionee is employed/in                                         33 1/3%
           service on or after July 29, 1999
           but not on or after July 29, 2000

           If Optionee is employed/in                                         66 2/3%
           service on or after July 29, 2000
           but not on or after July 29, 2001

           If Optionee is employed/in                                         100%
           service on or after July 29, 2001

      2.   The last sentence of Section 8(d) is hereby eliminated.



     Capitalized terms used herein and not otherwise defined shall have the
respective meanings assigned thereto in each agreement, respectively.

Very truly yours,

ALEXION PHARMACEUTICALS, INC.

By: /s/ John Fried
   -----------------------
Name: John H. Fried, Ph.D.
Title: Chairman of the Board



                                       AGREED AND ACCEPTED BY:


                                       /s/ Leonard Bell
                                      ----------------------------
                                         Leonard Bell, M.D.