SECURITIES AND EXCHANGE COMMISSION


                             Washington, D.C. 20549


                       -----------------------------------

                               AMENDMENT NO. 1 TO
                                    FORM 10-Q

                QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                                       OR

                For the quarterly period ended December 31, 1999


                           Commission File No. 0-15360


                        BIOJECT MEDICAL TECHNOLOGIES INC.
             (Exact name of registrant as specified in its charter)



               Oregon                                  93-1099680
- --------------------------------------         -----------------------------
   (Jurisdiction of incorporation)              (I.R.S. identification no.)

       7620 SW Bridgeport Road
          Portland, Oregon                                97224
- --------------------------------------         -----------------------------
(Address of principal executive offices)               (Zip code)


                                 (503) 639-7221
             -------------------------------------------------------
              (Registrant's telephone number, including areas code)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.  Yes [X] No [ ]

At December 31, 1999 there were 5,828,784  outstanding shares of common stock of
the registrant.





                                  PART II
                             OTHER INFORMATION

Item 1.   Legal Proceedings

          None during the quarter ended December 31, 1999.

Item 2.   Changes in Securities

On July 15, 1999, the Board of Directors  approved,  subject to the  shareholder
approval,  a proposal to amend the Articles of Incorporation to effect a reverse
stock split by exchanging five outstanding  shares of the Company's common stock
for one new share of the Company's common stock. At the Company's annual meeting
in September,  1999,  the  shareholders  approved the amendment to the Company's
Articles of  Incorporation  to effect a  one-for-five  reverse  stock split.  On
October 13, 1999, a one-for-five reverse stock split was effected.  Prior to the
reverse split,  29,011,236 shares of Common Stock were  outstanding,  as well as
options,  warrants  and  convertible  preferred  stock to acquire an  additional
24,378,928  shares of common stock. The reverse stock split decreased the number
of outstanding  shares of common stock to  approximately  5.8 million shares and
approximately  4.8 million  shares were  reserved for issuance  upon exercise of
outstanding options, warrants and the conversion of convertible preferred stock.

In December 1996, the Company  completed two private  placements of units,  each
unit  consisting  of one share of Common  Stock and one warrant to purchase  one
share of Common Stock at an exercise price of $5.00. Preferred Technology,  Inc.
acted  as  agent  in  connection  with the  first  placement  and in  connection
therewith,  received a placement  fee and a warrant to acquire  shares of Common
Stock at an exercise price per share of $4.140625. In December 1999, warrants to
purchase 20,286 shares of Common Stock were exercised at $5.00 per share.

The  warrants  and the shares  issued upon  exercise of the  warrants  have been
issued pursuant to an exemption from registration under Rule 506 of Regulation D
and Section 4(2) of the  Securities  Act. In relying upon such exemption (1) the
Company  did not  engage  in any  "general  solicitation,"  (ii)  the  purchaser
represented  and the  Company  reasonably  believed  that the  purchaser  was an
accredited  investor and had such  knowledge  and  experience  in financial  and
business  matters such that it was capable of evaluating the merits and risks of
the  prospective  investment  and was  able to bear  the  economic  risk of such
investment,  (iii)  the  purchaser  was  provided  access to all  necessary  and
adequate  information  to enable the  purchaser to evaluate the  financial  risk
inherent in making an investment, and (iv) the purchaser represented that it was
acquiring the shares for itself and not for distribution.

Aggregate   proceeds  to  the  Company  from  the  warrant   exercises   totaled
approximately  $101,000.  In December,  1999,  stock  option  exercises of 3,250
shares of common stock were exercised for an aggregate of approximately $8,129.

Item 3.   Defaults Upon Senior Securities

          None during the quarter ended December 31, 1999.

Item 4.   Submission of Matters to a Vote of Security Holders

          None during the quarter ended December 31, 1999.

Item 5.   Other Information

          On October 7, 1999,  Michael Sember  resigned from Bioject's  Board of
Directors.



                                       15



Item 6.   Exhibits and Reports on Form 8-K

          EXHIBITS:

          10.70     License and  Distribution  Agreement dated December 21, 1999
                    between  Bioject,   Inc.  and  Serono   Laboratories,   Inc.
                    (Confidential  treatment  has been granted  pursuant to Rule
                    24b-2 under the Securities Exchange Act of 1934, as amended.
                    Confidential portions have been omitted and filed separately
                    with the SEC.  This exhibit is being  refiled  following the
                    confidential treatment review.)

          27.1      Financial Data Schedule

           REPORTS ON FORM 8K:

            None during the quarter ended December 31, 1999














                                       16





                                SIGNATURE

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


                                    BIOJECT MEDICAL TECHNOLOGIES INC.
                                    (Registrant)



Date:  March 15, 2000               /s/ James O'Shea
                                    ---------------------------------
                                    James O'Shea

                                    Chairman, Chief Executive Officer
                                    and President

                                    /s/ Christine M. Farrell

                                    ---------------------------------
                                    Christine M. Farrell
                                    Controller and Secretary






                                  EXHIBIT INDEX
                                  -------------

EXHIBIT
NUMBER         EXHIBIT DESCRIPTION
- ------         -------------------

10.70          License  and  Distribution  Agreement  dated  December  21,  1999
               between Bioject, Inc. and Serono Laboratories, Inc. (Confidential
               treatment  has been  granted  pursuant  to Rule  24b-2  under the
               Securities  Exchange  Act  of  1934,  as  amended.   Confidential
               portions  have been  omitted and filed  separately  with the SEC.
               This  exhibit  is  being  refiled   following  the   confidential
               treatment review.)

27.1           Financial Data Schedule