SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549
                       -----------------------------------

                               AMENDMENT NO. 2 TO
                                    FORM 10-Q


                QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                For the quarterly period ended September 30, 1999


                           Commission File No. 0-15360


                        BIOJECT MEDICAL TECHNOLOGIES INC.
             (Exact name of registrant as specified in its charter)



               Oregon                                  93-1099680
- --------------------------------------         -----------------------------
   (Jurisdiction of incorporation)              (I.R.S. identification no.)

       7620 SW Bridgeport Road
          Portland, Oregon                                97224
- --------------------------------------         -----------------------------
(Address of principal executive offices)               (Zip code)


                                 (503) 639-7221
             -------------------------------------------------------
              (Registrant's telephone number, including areas code)

     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes [X] No [ ]

     At October 31, 1999 there were 5,802,248 outstanding shares of common stock
of the registrant.





                                  PART II
                             OTHER INFORMATION


Item 1.   Legal Proceedings

          None during the quarter ended September 30, 1999.

Item 2.   Changes in Securities

In connection with the Company's purchase of Elan's interest in Marathon at June
30, 1999, the Company and Elan agreed to certain  changes in the terms of Elan's
Series A Convertible  Preferred  Stock  ("Series A Stock").  The modified  terms
fixed the conversion  price of the Series A Stock at $1.50,  eliminating a prior
provision  that,  in  certain  circumstances,  allowed  the Series A Stock to be
converted at 80% of the then current fair market value of the  Company's  stock,
if such  value was less than  $1.50.  The terms were also  modified  to give the
Company  the right to redeem the Series A Stock for cash  within  ninety days of
receiving  notice of the intent to redeem all or part of the Series A Stock into
common stock of the Company. The redemption price is the original issuance price
of the Series A Stock being converted plus accumulated preferred stock dividends
thereon from the date of issuance of the Series A Stock.  Modifying the terms of
the  Series  A  Stock  required  shareholder  approval  of an  amendment  to the
Company's   Articles  of  Incorporation.   Amended  Articles  of  Incorporation,
reflecting the modified terms, was referred to the Company's shareholders at the
Company's  annual  meeting in September,  1999.  The  shareholders  approved the
amendment to the Company's  Articles of Incorporation to modify the terms to fix
the  conversion  price to $1.50.  As a result of the Reverse  Stock  Split,  the
conversion rate was adjusted to $7.50 per share.

On July 9, 1999,  the last sale price of the Company's  common stock as reported
on the NASDAQ  National  Market  System  was  ($0.50)  per  share.  The Board of
Directors  believed that the recent per share price of the Common Stock affected
the marketability of the existing shares, increased the amount and percentage of
transaction  costs paid by individual  stockholders,  and affected the potential
ability of the Company to raise capital by issuing additional shares. As a means
of  improving   marketability  of  the  Common  Stock,  reducing   stockholders'
transaction  costs,  increasing  the  number  of  shares  available  for  future
issuances,  and other  considerations,  on July 15, 1999, the Board of Directors
approved,  subject to the shareholder approval, a proposal to amend the Articles
of  Incorporation to effect a reverse stock split by exchanging five outstanding
shares of the Company's  common stock for one new share of the Company's  common
stock.  At the Company's  annual meeting in September,  1999,  the  shareholders
approved the amendment to the Company's  Articles of  Incorporation  to effect a
one-for-five  reverse stock split. The effective date of the reverse was October
13, 1999. At July 15,1999,  29,011,236  shares of Common Stock were outstanding,
as well as  options,  warrants  and  convertible  preferred  stock to acquire an
additional 24,378,928 shares of Common Stock. The Reverse Stock Split, decreased
the number of outstanding  shares of Common Stock to  approximately  5.8 million
shares and  approximately  4.8 million  shares are reserved  for  issuance  upon
exercise of  outstanding  options,  warrants and the  conversion of  convertible
preferred  stock,  Approximately  89.3 million  shares are  available for future
issuances.  Earnings  per share  reflect  post  split  shares  of  common  stock
outstanding

On the effective  date,  the total number of shares of Common Stock held by each
stockholder  converted  automatically into a right to receive a number of shares
and  fractions  thereof  of New  Common  Stock  equal to the number of shares of
Common Stock owned immediately prior to the Reverse Stock Split divided by five.
No fractional shares or scrip were issued and, in lieu thereof, each stockholder
who would  otherwise  have been  entitled to a fraction of a share of New Common
Stock would received a whole share of New Common Stock.

Approval of the Reverse Stock Split did not affect any stockholder's  percentage
ownership interest in the Company or proportional  voting power except for minor
differences  resulting from fractional  shares.  The Reverse Stock Split did not
reduce the number of shareholders of the Company. The shares of New Common Stock
issued  upon   approval  of  the  Reverse   Stock  Split  were  fully  paid  and
nonassessable.  The voting rights and other  privileges of the holders of Common
Stock was not affected  substantially  by adoption of the Reverse Stock Split or
the subsequent implementation thereof.



Item 3.   Defaults Upon Senior Securities

          None during the quarter ended September 30, 1999.

Item 4.   Submission of Matters to a Vote of Security Holders

At the annual general meeting of the shareholders of the Company held at 9:00 am
on September 16, 1999 in Portland,  Oregon, the following matters were submitted
to a vote of the shareholders:

Election of  directors.  The slate of directors  was  approved by the  Company's
shareholders with no director  receiving less than 22,754,544 votes in favor and
no more than 299,578 withheld. David de Weese received 22,755,544 votes in favor
and 298,578 votes  withheld;  William A. Gouveia  received  22,755,544  votes in
favor and 298,578 votes  withheld;  Edward Flynn  received  22,755,544  votes in
favor and 298,578 votes withheld. Shares voted totaled 23,054,122.

Amend Articles to amend the terms of the Series A Preferred  Stock. The proposal
passed receiving 11,859,655 votes in favor,  1,338,834 votes against and 333,225
votes abstaining, out of shares voted totaling 13,531,714.

Amend Articles of  Incorporation  and grant the Board of Directors the authority
to effect a reverse split.  The proposal passed  receiving  20,520,691  votes in
favor,  1,936,771  votes against and 2,877,085 votes  abstaining,  out of shares
voted totaling 25,334.547.

There were 29,011,236 common shares outstanding as of the date of record of July
24, 1999.

Item 5.   Other Information

     On October 7, 1999, Mike Sember resigned from Bioject's Board of Directors.

Item 6.   Exhibits and Reports on Form 8-K

          EXHIBITS

Exhibit
 Number        Description
- -------        -----------

 3.1*          Amended and Restated Articles of Incorporation of the Company

10.69+         Letter Agreement dated June 29, 1999

10.67+         Agreement I between  Bioject,  Inc. and  AngioSense,  Inc.  dated
               September 21, 1999

10.68+         Agreement II between  Bioject,  Inc. and  AngioSense,  Inc. dated
               September 21, 1999

27.1*          Financial Data Schedule

- -------------------------
*    previously filed

+    Confidential treatment has been granted with respect to certain portions of
     this exhibit  pursuant to an application for  Confidential  Treatment filed
     with the Commission  under Rule 24b-2(b) under the Securities  Exchange Act
     of 1934,  as  amended.  These  exhibits  are being  refiled  following  the
     confidential treatment review.


          REPORTS ON FORM 8K:

          On July 13, 1999, the Company filed a report on Form 8-K regarding the
          sale of Marathon's technology license.





                                SIGNATURE

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.



                                    BIOJECT MEDICAL TECHNOLOGIES INC.
                                    (Registrant)



Date:  March 15, 2000               /s/ James O'Shea
                                    ---------------------------------
                                    James O'Shea
                                    Chairman, Chief Executive Officer
                                    and President



                                    /s/ Christine M. Farrell
                                    ---------------------------------
                                    Christine M. Farrell
                                    Controller and Secretary






                                  EXHIBIT INDEX
                                  -------------


Exhibit
 Number        Description
- -------        -----------

 3.1*          Amended and Restated Articles of Incorporation of the Company

10.69+         Letter Agreement dated June 29, 1999

10.67+         Agreement I between  Bioject,  Inc. and  AngioSense,  Inc.  dated
               September 21, 1999

10.68+         Agreement II between  Bioject,  Inc. and  AngioSense,  Inc. dated
               September 21, 1999

27.1*          Financial Data Schedule

- -------------------------
*    previously filed

+    Confidential treatment has been granted with respect to certain portions of
     this exhibit  pursuant to an application for  Confidential  Treatment filed
     with the Commission  under Rule 24b-2(b) under the Securities  Exchange Act
     of 1934,  as  amended.  These  exhibits  are being  refiled  following  the
     confidential treatment review.