EXHIBIT 3.1


                              AMENDED AND RESTATED
                            ARTICLES OF INCORPORATION
                                       OF
                        BIOJECT MEDICAL TECHNOLOGIES INC.


                                    ARTICLE I

                                      Name

     The name of the corporation  (the  "Corporation")  shall be Bioject Medical
Technologies Inc.

                                   ARTICLE II

                                    Duration

     The Corporation's duration shall be perpetual.

                                   ARTICLE III

                                    Purposes

     The purposes for which the Corporation is organized are:

     Section 1. In general,  to carry on any lawful business whatsoever which is
calculated,  directly or indirectly, to promote the interests of the Corporation
or to enhance the value of its properties.

     Section  2. To  engage  in and carry on any  lawful  business  or trade and
exercise all powers  granted to a corporation  formed under the Oregon  Business
Corporation Act,  including any amendments thereto or successor statute that may
hereinafter be enacted.

                                   ARTICLE IV

                            Authorized Capital Stock

     Section 1.  Classes.  After  giving  effect to the reverse  stock split set
forth in Section 1.1, the  Corporation  shall be authorized to issue two classes
of stock to be designated,  respectively,  "Common Stock" and "Preferred Stock";
the total number of shares which the  Corporation  shall have authority to issue
is One Hundred Ten Million  (110,000,000);  the  authorized  number of shares of
Common Stock shall be One Hundred Million (100,000,000),  without par value; the
authorized   number  of  shares  of   Preferred   Stock  shall  be  Ten  Million
(10,000,000), without par value.





                                       1



     Section  1.1.  Each five shares of issued and  outstanding  Common Stock of
this Corporation are, on the effective date hereof,  automatically  reclassified
into one share of Common Stock of this  Corporation,  thereby giving effect to a
one-for-five  reverse stock split (the "Reverse Stock Split").  All  outstanding
rights and obligations  (including option plans,  stock options and the exercise
price thereof,  stock purchase  warrants and the exercise prices thereof and the
conversion terms of the Corporation's  shares of Series A Convertible  Preferred
Stock, Series B Convertible  Preferred Stock and Series C Convertible  Preferred
Stock)  relating to this  Corporation's  Common  Stock  shall be  mathematically
adjusted to reflect the Reverse Stock Split so that the  proportionate  ratio of
such  rights and  obligations  to the  reclassified  shares will be equal to the
proportionate  ratio of such rights and  obligations  to the shares  outstanding
immediately  prior  to such  reclassification.  In lieu of the  issuance  of any
fractional  shares that would otherwise result from the Reverse Stock Split, the
Corporation  shall  issue  to  any  shareholder  that  would  otherwise  receive
fractional  shares one whole share,  the  additional  shares hereby issued being
taken from authorized but theretofore unissued shares of Common Stock.

     Section 2. Preferred  Stock.  Shares of Preferred  Stock may be issued from
time to time in one or more  series.  Shares  of  Preferred  Stock  which may be
redeemed,  purchased or acquired by the  Corporation  may be reissued  except as
otherwise  provided by law. The board of directors of the  Corporation is hereby
authorized  to  fix  the  designations  and  powers,  preferences  and  relative
participating, optional or other rights, if any, and qualifications, limitations
or other restrictions thereof, including,  without limitation, the dividend rate
(and whether or not dividends are cumulative), conversion rights, if any, voting
rights,  rights and terms of redemption  (including sinking fund provisions,  if
any), redemption price and liquidation preferences of any wholly unissued series
of Preferred Stock and the number of shares constituting any such series and the
designation  thereof,  or any of them; and to increase or decrease the number of
shares of any series  subsequent to the issue of shares of that series,  but not
below the number of shares of such series then outstanding.

     Designation  of Rights and  Preferences  of Series A Convertible  Preferred
     Stock,  Series B  Convertible  Preferred  Stock  and  Series C  Convertible
     Preferred Stock

     Section 2.1.  Definitions.  The following  terms shall have the  respective
meanings ascribed to them below.

     "Board" shall mean the Board of Directors of the Corporation.

     "Business Day" shall mean any day other than  Saturday,  Sunday or a day on
which  federally-chartered  banks  located  in New York,  New York or  Portland,
Oregon are permitted by law to be closed.

     "Closing Date" shall mean October 15, 1997.

     "Closing  Price" at any date shall mean the last reported sale price of the
Common Stock on the NASDAQ Stock Market or other principal  market of the Common
Stock on such date.





                                       2



     "Common Stock" shall mean, collectively, the Corporation's Common Stock and
any capital  stock of any class of the  Corporation  (other  than any  Preferred
Stock) hereafter  authorized that is not limited to a fixed amount of percentage
of par or stated  value in  respect  of the  rights of the  holders  thereof  to
participate in dividends or in the  distribution of assets upon any liquidation,
dissolution or winding up of the Corporation.

     "Conversion  Stock"  shall mean shares of the  Corporation's  Common  Stock
issuable upon the conversion of any shares of Preferred Stock.

     "Excluded  Stock"  shall mean (i) shares of Common Stock issued or reserved
for issuance by the Corporation as a stock dividend  payable in shares of Common
Stock, or upon any  subdivision or split-up of the outstanding  shares of Common
Stock, or upon conversion of shares of the Preferred Stock, (ii) up to 3,650,000
shares of  Common  Stock (or  Rights  (as  defined  below))  therefor  issued to
directors, officers or employees of the Corporation or its affiliates (or in the
case of options,  granted at an exercise  price) at less than Fair Value under a
duly-enacted  stock option or  compensation  plan, or (iii) any shares of Common
Stock issuable upon exercise of any warrants  currently  outstanding or warrants
which the  Corporation  has  committed,  as of October 15, 1997, to issue in the
future.

     "Fair Value" shall mean the fair market value of any  securities  or assets
as reasonably and in good faith determined by the Board.

     "Junior  Securities" shall mean any of the Corporation's  equity securities
(whether or not currently authorized) that are junior in liquidation  preference
to the Preferred Stock.

     "Liquidation  Value" of any share of Series A  Preferred  Stock or Series B
Preferred  Stock as of any  particular  date shall be equal to $15.00 per share.
Liquidation Value of Series C Preferred Stock is the Series C Issuance Price.

     "Market Price" of any security shall mean the average of the closing prices
of such security's sales on all securities  exchanges on which such security may
at the time be listed,  or, if there have been no sales on any such  exchange on
any day,  the  average of the highest  bid and lowest  asked  prices on all such
exchanges  at the end of such  day,  or, if on any day such  security  is not so
listed,  the average of the  representative  bid and asked prices  quoted in the
NASDAQ  Stock  Market as of 4:00  p.m.,  New York  time,  or, if on any day such
security is not quoted in the NASDAQ  Stock  Market,  the average of the highest
bid and lowest asked prices on such day in the domestic  over-the-counter market
as reported  by the  National  Quotation  Bureau,  Incorporated,  or any similar
successor  organization,  in each  such  case  averaged  over a period of the 10
trading days preceding the  determination  date. If at any time such security is
not listed on any  securities  exchange or quoted in the NASDAQ  Stock Market or
the over-the-counter market, the "Market Price" shall be the Fair Value thereof.




                                       3



     "Person"  shall  mean an  individual,  a  partnership,  a  corporation,  an
association,  a joint stock company, a trust, a joint venture, an unincorporated
organization  and a governmental  entity or any department,  agency or political
subdivision thereof.

     "Preferred  Stock"  shall mean the Series A Preferred  Stock,  the Series B
Preferred Stock and the Series C Preferred Stock,  or, as the context  requires,
all such series of preferred stock of the Corporation.

     "Preferred  Issuance Price" shall mean the purchase price per share for the
Series A Preferred Stock,  which is $15.00, and the purchase price per share for
the Series B Preferred Stock, which is $15.00.

     "Series  C  Issuance  Price"  means the  original  price per share at which
Series C Preferred Stock is issued.

     "Subsidiary"  shall  mean any  Person  of which the  shares of  outstanding
capital  stock or other equity  interests,  as the case may be,  possessing  the
voting  power under  ordinary  circumstances  in electing the board of directors
are,  at the time as of which  any  determination  is being  made,  owned by the
Corporation either directly or indirectly through subsidiaries.

     Section  2.2.  Preferred  Stock.  (a) Series A Preferred  Stock.  1,235,000
shares of the preferred stock,  without par value, of the Corporation are hereby
constituted  as a series of preferred  stock of the  Corporation  designated  as
Series A  Convertible  Preferred  Stock (the "Series A Preferred  Stock").  Such
amount shall be adjusted by the Corporation in the event that any adjustments to
the Series A Preferred Stock are required as set forth herein, including Section
2.7 hereof,  and, in connection  therewith,  the Corporation shall promptly take
all  necessary or  appropriate  actions and make all  necessary  or  appropriate
filings in connection therewith.

     (b)  Series B  Preferred  Stock.  200,000  shares of the  preferred  stock,
without par value,  of the  Corporation  are hereby  constituted  as a series of
preferred stock of the Corporation  designated as Series B Convertible Preferred
Stock (the  "Series B Preferred  Stock").  Such amount  shall be adjusted by the
Corporation in the event that any  adjustments  to the Series B Preferred  Stock
are  required  as set forth  herein,  including  Section  2.7  hereof,  and,  in
connection  therewith,  the  Corporation  shall  promptly  take all necessary or
appropriate  action and make all necessary or appropriate  filings in connection
therewith.

     (c)  Series C  Preferred  Stock.  500,000  shares of the  preferred  stock,
without par value,  of the  Corporation  are hereby  constituted  as a series of
preferred stock of the Corporation  designated as Series C Convertible Preferred
Stock (the  "Series C Preferred  Stock").  Such amount  shall be adjusted by the
Corporation in the event that any  adjustments  to the Series C Preferred  Stock
are  required  as set forth  herein,  including  Section  2.7  hereof,  and,  in
connection  therewith,  the  Corporation  shall  promptly  take all necessary or
appropriate  action and make all necessary or appropriate  filings in connection
therewith.





                                       4



     Section 2.3.  Dividends.  (a) General.  (1) Series A Preferred Stock.  Each
outstanding  share of Series A Preferred  Stock shall accrue a dividend equal to
9% per  annum of the  Preferred  Issuance  Price of  Series A  Preferred  Stock,
compounded semi-annually beginning six months from the date of first issuance of
Series A Preferred Stock;  such dividend shall be paid by issuance of additional
shares of Series A Preferred  Stock,  based upon a value equal to the  Preferred
Issuance Price.

     (2)  Series B  Preferred  Stock.  The  holder  of each  share  of  Series B
Preferred Stock shall be entitled to receive, pro rata among such holders and on
a pari passu  basis with the  holders  of the Series C  Preferred  Stock and the
holders of Common Stock,  as if the Series B Preferred  Stock had been converted
into Common Stock immediately prior to the record date in respect thereof,  when
and as declared by the Board out of funds legally  available for the declaration
and payment of dividends, cash dividends at the same rate and in the same amount
per share as any and all  dividends  declared  and paid in respect of the Common
Stock.  Except as set forth above, such holders shall not be entitled to receive
any dividends.

     (3)  Series C  Preferred  Stock.  The  holder  of each  share  of  Series C
Preferred Stock shall be entitled to receive, pro rata among such holders and on
a pari passu  basis with the  holders  of the Series B  Preferred  Stock and the
holders of Common Stock,  as if the Series C Preferred  Stock had been converted
into Common Stock immediately prior to the record date in respect thereof,  when
and as declared by the Board out of funds legally  available for the declaration
and payment of dividends, cash dividends at the same rate and in the same amount
per share as any and all  dividends  declared  and paid in respect of the Common
Stock.  Except as set forth above, such holders shall not be entitled to receive
any dividends.

     (b) Payment of Dividends.  (1) Series A Preferred Stock.  Dividends accrued
and unpaid on shares of Series A Preferred Stock as of the Mandatory  Conversion
Date (as defined in Section 2.6(a)(1) below) shall be payable in accordance with
Section 2.6 below.

     (2) Series B Preferred Stock.  Dividends payable in respect of the Series B
Preferred  Stock shall be paid as and when  dividends are paid in respect of the
Common Stock.

     (3) Series C Preferred Stock.  Dividends payable in respect of the Series C
Preferred  Stock shall be paid as and when  dividends are paid in respect of the
Common Stock.

     (4) Change in Dividend  Rate. If the  Corporation  shall fail to declare or
pay a dividend on a date on which  dividends  are to be  compounded  pursuant to
Section  2.3(a)(1)  hereof,  dividends on each share of Series A Preferred Stock
shall  thereupon  begin  to  accrue  at the  rate  of 9% of the  sum of (a)  the
Preferred Issuance Price and (b) accrued and unpaid dividends on such date. If a
dividend that was accrued and unpaid on a date dividends are to be compounded is
subsequently paid, the rate at which dividends accrue shall thereupon be lowered
to reflect such payment.





                                       5



     Section 2.4. Liquidation.  Upon any liquidation,  dissolution or winding up
of the Corporation,  each holder of Preferred Stock shall be entitled to receive
from amounts remaining after satisfaction of creditors and holders of securities
(if any) with  liquidation  preferences  senior to the Preferred  Stock, and pro
rata based on the respective outstanding liquidation preferences with holders of
securities with a liquidation  preference pari passu to the Preferred  Stock, an
amount  equal to the  Liquidation  Value,  plus  accrued  and  unpaid  dividends
thereon,  per share multiplied by the number of shares of Preferred Stock,  held
by  such  holder,  until  paid  in  full,  in  preference  and  priority  to any
distribution to any holder of Junior  Securities.  The Corporation shall provide
written notice of such liquidation,  dissolution or winding up, not less than 30
days prior to the payment  date  stated  therein,  to each record  holder of any
shares of Preferred Stock.

     Section 2.5.  Voting Rights.  (a) No Voting.  Except as provided in Section
2.5(b)  below  or as  required  by the  Oregon  Business  Corporation  Act,  the
outstanding  shares of  Preferred  Stock  shall not be  entitled  to vote on any
matter as to which stockholders of the Corporation shall be entitled to vote.

     (b)  Special  Voting  Rights.  The  Corporation  shall not,  without  first
obtaining the  affirmative  vote or written consent of a majority in interest of
the Series A Preferred Stock, voting as a class:

     (1)  amend or  repeal  any  provision  of,  or add any  provision  to,  the
Corporation's  Articles  of  Incorporation  or  By-laws  if  such  action  would
adversely  alter   preferences,   rights,   privileges  or  powers  of,  or  the
restrictions provided herein for the benefit of, the Series A Preferred Stock;

     (2) create a series of Preferred Stock with a liquidation preference senior
to the Series A Preferred Stock;

     (3) effect any merger, consolidation or similar transaction; or

     (4)  increase  or  decrease  the  number of  authorized  shares of Series A
Preferred Stock, except as required by Section 2.2 hereof.

     Section  2.6.  Conversion.  (a) Series A  Preferred  Stock.  (1)  Mandatory
Conversion. All holders of Series A Preferred Stock shall be required to convert
all of the  outstanding  shares of Series A  Preferred  Stock as of the  seventh
anniversary of the Closing Date (the "Mandatory Conversion Date"), in which case
the aggregate  Preferred  Issuance Price of all shares of the Series A Preferred
Stock plus  accrued and unpaid  dividends  thereon  held by each holder shall be
converted  into a number of shares of Common Stock  determined  by dividing such
sum by a price per share of Common  Stock  equal to $1.50 per share (the  "Fixed
Mandatory  Conversion  Rate"). In the event that any holder shall provide notice
to the  Corporation of its intention to convert such holder's shares of Series A
Preferred Stock, as provided above, the Corporation shall have the right, within
90 days of receipt of such  notice and upon five  business  days'  notice to the
holders, to cause to be redeemed for cash the shares of Series A Preferred Stock
subject to such notice,  at a price equal to aggregate  purchase  price for such
shares of Series A





                                       6



Preferred  Stock  plus  mandatory  dividends  thereon  at a rate equal to 9% per
annum,  from the date of issuance  until the date redeemed in full. In the event
that such cash amount is not paid within such  90-day  period,  such  redemption
right shall lapse and be of no further  force and effect,  and the holders shall
thereupon have the right once again to convert such shares of Series A Preferred
Stock into  shares of the  Corporation's  Common  Stock.  During such 90-day (or
shorter,  if  redeemed,  as set forth  above)  period,  the  holders of Series A
Preferred  Stock  shall not  convert  such stock into the  Corporation's  Common
Stock, whether or not the Corporation exercises its right of redemption.

     (2) Conversion  Prior to Mandatory  Conversion Date. Prior to the Mandatory
Conversion Date, all holders of Series A Preferred Stock shall have the right to
convert each share of Series A Preferred  Stock into ten shares of Common Stock,
without  giving effect to accrued and unpaid  dividends,  but subject to Section
2.6(e) below (the "Anti-dilution Adjustments").

     (b) Series B Preferred  Stock.  Series B Preferred  Stock is convertible in
the same manner and subject to the same terms and  conditions as provided for in
Section 2.6(a) above with respect to the holders of Series A Preferred Stock.

     (c) Series C Preferred  Stock.  (1)  Mandatory  Conversion.  All holders of
Series C Preferred  Stock  shall be  required to convert all of the  outstanding
shares of Series C Preferred Stock as of the Mandatory Conversion Date, in which
case the  aggregate  Preferred  Issuance  Price of all  shares  of the  Series C
Preferred  Stock plus accrued and unpaid  dividends  thereon held by each holder
shall be  converted  into a number  of  shares of  Common  Stock  determined  by
dividing such sum by one-tenth of the Series C Issuance Price.

     (2) Conversion  Prior to Mandatory  Conversion Date. Prior to the Mandatory
Conversion Date, all holders of Series C Preferred Stock shall have the right to
convert each share of Series C Preferred  Stock into ten shares of Common Stock,
without  giving  effect to accrued  and  unpaid  dividends,  but  subject to the
Anti-dilution Adjustments.

     (c)  Conversion  Procedure.  (1) Before  any holder of shares of  Preferred
Stock  shall be  entitled  to convert  any of such  shares into shares of Common
Stock,  such holder  shall  surrender  the  certificate  or  certificates,  duly
endorsed,  at the office of the  Corporation  or of any  transfer  agent for the
Preferred  Stock,  and  shall  give  written  notice to the  Corporation  at its
principal  corporate  office of the  election  to convert  such shares and shall
state therein the name or names in which the  certificate  or  certificates  for
shares of Common Stock are to be issued.

     (2) Each  conversion  of any shares of  Preferred  Stock shall be deemed to
have been effected on the close of business on the date on which the certificate
or  certificates  representing  such  Preferred  Stock to be converted have been
surrendered at the principal  corporate  office of the Corporation or the office
of any transfer agent for the Preferred  Stock.  At such time as such conversion
has been effected,  the rights of the holder of such Preferred Stock as a holder
shall  cease,  the Person or Persons in whose name or names any  certificate  or
certificates for shares of Conversion Stock are to be issued upon such





                                       7



conversion shall be deemed to have become the holder or holders of record of the
shares of Conversion Stock represented thereby.

     (3) As soon as possible  after a conversion  has been  effected (but in any
event  within  five  business  days  in the  case  of  clause  (6)  below),  the
Corporation or its transfer agent shall deliver to the converting holder:

     (i) a  certificate  or  certificates  representing  the number of shares of
Conversion Stock issuable by reason of such conversion in such name or names and
such denomination or denominations as the converting holder has specified; and

     (ii)  payment in an amount  equal to the amount  payable  under  clause (6)
below with respect to such conversion.

     (4) The  issuance  of  certificates  for  shares of  Conversion  Stock upon
conversion of the Preferred Stock shall be made without charge to the holders of
such Preferred Stock for any cost incurred by the Corporation in connection with
such  conversion and the related  issuance of shares of Conversion  Stock.  Upon
conversion of each share of Preferred Stock, the Corporation shall take all such
actions as are necessary in order to ensure that the  Conversion  Stock issuable
with  respect  to such  conversion  shall  be  validly  issued,  fully  paid and
nonassessable.

     (5) The  Corporation  shall not close its books against the transfer of the
Preferred Stock or of Conversion Stock issued or issuable upon conversion of the
Preferred Stock in any manner which interferes with the timely conversion of the
Preferred Stock.  The Corporation  shall assist and cooperate with any holder of
the  Preferred  Stock or  Conversion  Stock  required  to make any  governmental
filings or obtain any  governmental  approval prior to or in connection with any
conversion  of shares  hereunder  (including,  without  limitations,  making any
filings required to be made by the Corporation).

     (6) If any fractional interest in a share of Conversion Stock would, except
for the provisions of this clause (6), be deliverable upon any conversion of the
Preferred  Stock,  the  Corporation,  in lieu of delivering the fractional share
therefor, shall pay an amount to the holder thereof equal to the Market Price of
such fractional interest as of the date of conversion.

     (7) The  Corporation  shall at all times reserve and keep  available out of
its authorized but unissued shares of Conversion  Stock,  solely for the purpose
of issuance upon the conversion of the Preferred Stock, such number of shares of
Conversion  Stock  issuable  upon the  conversion of all  outstanding  shares of
Preferred  Stock.  All shares of Conversion  Stock which are so issuable  shall,
when issued,  be duly and validly issued,  fully paid and nonassessable and free
from all taxes,  liens and charges.  The Corporation shall take all such actions
as may be necessary to ensure that all such shares of Conversion Stock may be so
issued without violation of any applicable law or governmental regulation or any
requirements of any domestic  securities exchange or market upon which shares of
Conversion  Stock may be listed  (except for official  notice of issuance  which
shall be immediately delivered by the Corporation upon each such





                                       8



issuance and except for filings, notices of applicability and permissions solely
within the control of, or laws and regulations solely applicable to, the holders
of the Preferred Stock).

     (e)  Anti-dilution  Adjustments.  (1) Changes in Common Stock.  In case the
Corporation  shall at any time or from  time to time  after  the date of  filing
these  Articles of Amendment  (i) pay a dividend or make any other  distribution
with respect to its Common Stock in shares of Common Stock,  (ii)  subdivide its
outstanding  shares of Common  Stock  into a greater  number of shares of Common
Stock,  (iii) combine its  outstanding  shares of Common Stock or (iv) issue any
shares  of  its  capital  stock  or  other  assets  in  a  reclassification   or
reorganization  of the Common  Stock  (including  any such  reclassification  in
connection  with a  consolidation  or  merger in which  the  Corporation  is the
continuing  entity),  then the number and kind of shares of capital stock of the
Corporation  or other  assets that may be received  upon the  conversion  of the
Preferred  Stock shall be adjusted to the number of shares of  Conversion  Stock
and amount of any such  securities,  cash or other  property of the  Corporation
which the holders  would have owned or have been  entitled to receive  after the
happening  of any of the events  described  above had the  Preferred  Stock been
converted  immediately prior to the record date (or, if there is no record date,
the effective  date) for such event.  An adjustment made pursuant to this clause
(1)  shall  become   effective   upon  the  effective   date  of  such  payment,
sub-division,  combination or issuance as described  above. Any Conversion Stock
or other  assets  to be  acquired  as a result of such  adjustment  shall not be
issued  prior to the  effective  date of such  event.  For the  purposes of this
clause (1), the number of shares of Common Stock at any time  outstanding  shall
not include shares held in the treasury of the Corporation.  Notwithstanding any
other  provision  of this  Section  2.6(e)(1),  an action  described  in Section
2.6(e)(1)(i),  (ii) or (iii)  hereof  shall not  affect  the number of shares of
Conversion Stock issued upon mandatory  conversion of the Preferred Stock except
by operation of Section 2.6(e)(5) hereof.

     (2) Issuance of Rights.  In case the Corporation shall issue to all holders
of its Common Stock rights, options or warrants to subscribe for or purchase, or
other securities  exchangeable for or convertible  into,  shares of Common Stock
that are not  distributed  to  holders  of  Preferred  Stock  (any such  rights,
options, warrants or other securities, collectively, "Rights") (excluding rights
to purchase  Common Stock  pursuant to a Corporation  plan for  reinvestment  of
dividends  or interest  and  excluding  any  Excluded  Stock) at a  subscription
offering,  exercise  or  conversion  price  per  share (as  defined  below,  the
"offering price per share") which,  before deduction of customary  discounts and
commissions, is lower than the current Market Price per share of Common Stock on
the  record  date of such  issuance  or grant,  whether  or not,  in the case of
Rights, such Rights are immediately exercisable or convertible,  then the number
of shares of Conversion  Stock issuable upon  conversion of the Preferred  Stock
shall be  adjusted  by  multiplying  the  number of shares of  Conversion  Stock
issuable  upon  conversion  of the  Preferred  Stock  immediately  prior  to any
adjustment  in  connection  with  such  issuance  or  grant by a  fraction,  the
denominator  of which shall be the number of shares of Common Stock  outstanding
(exclusive  of any  treasury  shares) on the record date of issuance or grant of
such Rights plus the number of shares  which the  aggregate  offering  price (as
defined below) of the total number of shares of Common Stock so offered would





                                       9



purchase at the  current  Market  Price per share of Common  Stock on the record
date,  and the  numerator  of which is the  number of  shares  of  Common  Stock
outstanding  plus the aggregate  number of shares of Common Stock  issuable upon
exercise of the rights.  Such  adjustment  shall be made  immediately  after the
record date for the  issuance or granting of such  Rights.  For purposes of this
clause,  the  "offering  price per share" of Common Stock shall,  in the case of
Rights, be determined by dividing (x) the total amount received or receivable by
the Corporation in  consideration  of the issuance of such Rights plus the total
consideration  payable to the Corporation  upon exercise thereof (the "aggregate
offering  price"),  by (y) the total number of shares of Common Stock covered by
such Rights.

     (3) Dividends and  Distributions.  In case the Corporation shall distribute
to all holders of Common Stock any dividend or other  distribution  of evidences
of its  indebtedness or other assets (in each case other than cash dividends and
other than as provided in clause (1) above in which the holders of the Preferred
Stock are otherwise  entitled to share, as provided herein) or Rights,  then, in
each case,  all holders of the Preferred  Stock shall be entitled to receive all
of the same  dividends,  distributions  or  Rights,  as the case may be,  as the
holders of Common Stock,  on an as-converted  basis, as and when  distributed to
the  holders of Common  Stock,  at such time,  if any,  that the  holders of the
Preferred  Stock shall have  elected to convert such stock to Common  Stock,  as
provided herein.

     (4) Computations.  For the purpose of any computation under clauses (1) and
(2) above,  the current Market Price per share of Common Stock at any date shall
be as set forth in (i) the  definition  of Market  Price for the 10  consecutive
trading days commencing 20 trading days prior to the earlier to occur of (A) the
date as of which the Market Price is to be computed or (B) the last full trading
day before  the  commencement  of  "ex-dividend"  trading  in the  Common  Stock
relating to the event  giving rise to the  adjustment  required by clause (1) or
(2) or (ii) any other arm's-length  adjustment formula that the Board may use in
good faith.  In the event the Common Stock is not then publicly traded or if for
any other  reason  the  current  market  price per  share  cannot be  determined
pursuant to the foregoing provisions of this clause (4) the current market price
per share shall be the Fair Value thereof.

     (5) Adjustment.  Whenever the number of shares of Conversion Stock issuable
upon voluntary conversion of the Series A Preferred Stock and Series B Preferred
Stock is adjusted  as  provided  under  clause (1) or (2),  the Fixed  Mandatory
Conversion Rate shall be adjusted by multiplying such prices  immediately  prior
to such adjustment by a fraction,  the numerator of which shall be the number of
shares of Conversion  Stock issuable upon voluntary  conversion of any shares of
Series A Preferred Stock or Series B Preferred Stock  immediately  prior to such
adjustment,  and the  denominator  of which  shall be the  number  of  shares of
Conversion  Stock issuable upon  voluntary  conversion of any shares of Series A
Preferred Stock or Series B Preferred Stock immediately thereafter. Whenever the
number of shares of Conversion  Stock issuable upon voluntary  conversion of the
Series C Preferred  Stock is adjusted as provided  under  clause (1) or (2), the
Series C Issuance Price shall be adjusted by multiplying such prices immediately
prior to such  adjustment  by a fraction,  the  numerator  of which shall be the
number of





                                       10



shares of Conversion  Stock issuable upon voluntary  conversion of any shares of
Series  C  Preferred  Stock  immediately  prior  to  such  adjustment,  and  the
denominator of which shall be the number of shares of Conversion  Stock issuable
upon voluntary  conversion of any shares of Series C Preferred Stock immediately
thereafter.

     (6)  Securities.  For the purpose of this  Section 2.6, the term "shares of
Common  Stock"  shall mean (i) the class of stock  designated  as Common  Stock,
without par value, of the Corporation on the date of filing this  Certificate or
(ii)  any  other  class  of  stock   resulting   from   successive   changes  or
reclassifications  of such shares  consisting solely of changes in par value, or
from par value to no par value, or from no par value to par value.

     (7)  Re-Adjustment.  If, at any time after any  adjustment to the number of
Shares of Conversion  Stock issuable upon  conversion of the Preferred Stock and
the Conversion Price shall have been made pursuant to clause (2) of this Section
2.6,  any rights,  options,  warrants or other  securities  convertible  into or
exchangeable for shares of Common Stock shall have expired, or any thereof shall
not have  been  exercised,  the  Conversion  Price  and the  number of shares of
Conversion  Stock issuable upon  conversion of the Preferred  Stock shall,  upon
such  expiration,  be readjusted  and shall  thereafter be such as it would have
been had it been  originally  adjusted (or had the original  adjustment not been
required,  as the case may be) as if (A) the only shares of Common Stock offered
were the  shares  of  Common  Stock,  if any,  actually  issued or sold upon the
exercise  of such  rights,  options or  warrants  and (B) such  shares of Common
Stock, if any, were issued or sold for the  consideration  actually  received by
the Corporation for the issuance,  sale or grant of all such rights,  options or
warrants whether or not exercised;  provided,  further that no such readjustment
shall have the effect of  increasing  the  Conversion  Price or  decreasing  the
number of shares of Conversion  Stock issuable upon  conversion of the Preferred
Stock by an amount  (calculated  by  adjusting  such  increase  or  decrease  as
appropriate  to account for all other  adjustments  pursuant to this Section 2.6
following  the date of the original  adjustment  referred to above) in excess of
the amount of the adjustment initially made in respect of the issuance,  sale or
grant of such rights, options or warrants.

     (e)  Reorganization,  Reclassification  Consolidation,  Merger or Sale. Any
recapitalization,  reorganization, reclassification, consolidation, merger, sale
of all or  substantially  all of the  Corporation's  assets to another Person or
other  transaction  which is effected  in such a manner  that  holders of Common
Stock are entitled to receive (either  directly or upon subsequent  liquidation)
stock,  securities  or assets with respect to or in exchange for Common Stock is
referred  to herein as an "Organic  Change".  Prior to the  consummation  of any
Organic Change, the Corporation shall make appropriate provisions to ensure that
each of the holders of each share of the Preferred  Stock shall  thereafter have
the right to acquire and receive,  in lieu of or in addition to (as the case may
be) the  shares of  Conversion  Stock  immediately  theretofore  acquirable  and
receivable upon the conversion of such holder's  Preferred Stock, such shares of
stock,  securities  or assets as such holder would have  received in  connection
with such  Organic  Change if such  holder had  converted  its  Preferred  Stock
immediately  prior to such Organic  Change.  In each such case, the  Corporation
shall also make  appropriate  provisions  to ensure that the  provisions of this
Section 2.6 hereof shall  thereafter be applicable to the Preferred  Stock.  The
Corporation shall not effect any such





                                       11



consolidation,  merger or sale,  unless prior to the consummation  thereof,  the
successor   corporation   (if  other  than  the   Corporation)   resulting  from
consolidation  or merger or the  corporation  purchasing  such assets assumes by
written  instrument the obligation to deliver to each such holder such shares of
stock,  securities  or assets as, in accordance  with the foregoing  provisions,
such holder may be entitled to acquire.

     (f) Notices.  (1)  Immediately  upon any adjustment of the number of shares
issuable upon  conversion of the Preferred  Stock,  the  Corporation  shall give
written notice thereof to all holders of the Preferred  Stock,  setting forth in
reasonable detail and certifying the calculation of such adjustment.

     (2) The  Corporation  shall  give  written  notice  to all  holders  of the
Preferred  Stock  at least 10 days  prior to the date on which  the  Corporation
closes  its  books  or takes a record  of  determining  rights  to  receive  any
dividends or  distributions.  The Corporation  shall also give written notice to
the holders of the  Preferred  Stock at least 30 days prior to the date on which
Organic Change shall occur.

     Section 2.7. Redemption. (a) Series A Preferred Stock. (i) General. Subject
to the provisions of Section 2.6 above,  shares of Series A Preferred  Stock may
be redeemed by the Corporation,  as follows,  upon at least 45 days' and no more
than 90 days' prior written notice, at a price equal to the sum of the aggregate
Preferred Issuance Price of the Series A Preferred Stock plus accrued and unpaid
dividends.  From and after the third  anniversary  of the Closing  Date,  if the
Closing  Price  shall  be  equal  to or  greater  than  $2.25  (subject  to  the
anti-dilution  adjustments  described in Section  2.6(e)(1) above) for 20 out of
any 30 consecutive  trading days on or prior to any such applicable date (or, if
thereafter,  prior  to any  date for such a  redemption  if not  effected  prior
thereto) (the  "Redemption  Price  Condition"),  the Corporation  shall have the
right to redeem  one-third of the Series A Preferred  Stock (as to the Preferred
Issuance Price thereof),  together with one-third of the then-accrued and unpaid
dividends  through  such  date.  From and after the  fourth  anniversary  of the
Closing Date, if the Redemption  Price Condition is met, the  Corporation  shall
have the right to redeem an additional one-third of the Series A Preferred Stock
(as to the  Preferred  Issuance  Price  thereof),  together with one-half of the
then-accrued  and unpaid  dividends at such date (or two-thirds of  then-accrued
and  unpaid  dividend  at the  second  date if no Series A  Preferred  Stock was
previously  redeemed at or after the first such date).  From and after the fifth
anniversary of the Closing Date, if the Redemption  Price  Condition is met, the
Corporation shall have the right to redeem the balance of the Series A Preferred
Stock,  together with the remaining  accrued and unpaid  dividends at such date.
Prior to redemption,  the  Corporation  must provide the  applicable  redemption
notice within 60 days of the achievement of the Redemption Price Condition.

     (ii)  Early  Redemption.  The  Series A  Preferred  Stock  (or any  portion
thereof)  may be  redeemed  by the  Corporation  prior  to such  three,  four or
five-year  period,  as applicable,  only in the event the Corporation shall have
reasonably  determined,  in good faith,  after  consultation  with the  original
holder of shares of Series A Preferred  Stock to abandon the  development of the
Technology  (as defined in the  Securities  Purchase  Agreement  dated as of the
Closing Date among the  Corporation  and Elan  International  Services,  Ltd., a
Bermuda corporation) or products based on the Technology.





                                       12



     (iii) Notice of Redemption. Not less than 45 days but not more than 90 days
prior to the date of any redemption (each, a "Redemption Date"), as permitted by
this Section 2.7(a),  the Corporation  shall send a written notice of redemption
(the "Notice") to each holder of Series A Preferred  Stock to be redeemed in the
manner provided herein. The notice shall identify:

     (1) the Redemption Date;

     (2) the redemption price to be paid to such holder,  as provided above (the
"Redemption Price"), and applicable to such Series A Preferred Stock;

     (3) the  number of shares of Common  Stock  into  which a share of Series A
Preferred  Stock,  Series B Preferred Stock or Series C Preferred  Stock, as the
case may be, is convertible;

     (4) the name and address of the transfer  agent,  if any, in respect of the
Series A Preferred Stock;

     (5) that Series A Preferred Stock called for redemption may be converted by
the  holder,  as  otherwise  provided  herein,  at any time  before the close of
business on the Redemption Date; and

     (6) that Series A Preferred Stock called for redemption must be surrendered
to the transfer agent at the office of the  Corporation or its transfer agent to
collect the Redemption Price.

     (iv) Effect of Notice of  Redemption.  Upon the Notice,  Series A Preferred
Stock called for redemption shall become due and payable on the Redemption Date,
unless  converted prior to such date, and at the Redemption  Price stated in the
Notice.  Upon  surrender to the  Corporation  or transfer  agent shares shall be
redeemed and the Redemption  Price stated in the Notice shall be paid in cash in
full.

     (b) Series B Preferred  Stock.  Shares of Series B Preferred Stock shall be
redeemable by the  Corporation  in the same manner and subject to the same terms
and conditions as set forth for redemption of shares of Series A Preferred Stock
in Section 2.7(a) above.

     (c) Series C Preferred  Stock.  Shares of Series C Preferred Stock shall be
redeemable by the  Corporation  in the same manner and subject to the same terms
and conditions as set forth for redemption of shares of Series A Preferred Stock
in Section 2.7(a) above, except that shares of Series C Preferred Stock shall be
redeemed at a price equal to the sum of the  aggregate  Series C Issuance  Price
plus accrued and unpaid dividends.

     Section  2.8.  Registration  of  Transfer.  The  Corporation  shall  keep a
register for the registration of the record holders of the Preferred Stock. Upon
the surrender of any certificate representing any shares of Preferred Stock, the
Corporation  shall,  at the  request of the record  holder of such  certificate,
execute and deliver (at the Corporation's expense,





                                       13



provided  that the holder  will be  responsible  for any  transfer  taxes if the
certificate  is register in a new name) a new  certificate  or  certificates  in
exchange  therefore  representing  in the  aggregate the number of shares of the
Preferred Stock, as applicable, represented by the surrendered certificate. Each
such new  certificate  shall be registered in such name and shall represent such
number of shares of the Preferred  Stock, as applicable,  as is requested by the
holder of the surrendered  certificate and shall be  substantially  identical in
form to the surrendered certificate, and dividends shall accrue on the Preferred
Stock  represented by such new certificate from the date to which dividends have
been  fully  paid  on  such  Preferred  Stock  represented  by  the  surrendered
certificate.

     Section 2.9. Replacement.  Upon receipt of evidence reasonably satisfactory
to the Corporation (an affidavit of the registered  holder and an undertaking of
indemnity from a creditworthy indemnitor shall be satisfactory) of the ownership
and the loss,  theft,  destruction or mutilation of any  certificate  evidencing
shares  of the  Preferred  Stock,  and in the  case of any such  loss,  theft or
destruction,   upon  receipt  of  indemnity   reasonably   satisfactory  to  the
Corporation,  or,  in the case of any such  mutilation  upon  surrender  of such
certificate,  the Corporation shall (at its expense) execute and deliver in lieu
of such  certificate a new certificate of like kind  representing  the number of
shares of such series represented by such lost,  stolen,  destroyed or mutilated
certificate  and dated the date of such lost,  stolen,  destroyed  or  mutilated
certificate,  and dividends shall accrue on the Preferred  Stock  represented by
such new  certificate  from the date to which  dividends have been fully paid on
such lost, stolen, destroyed or mutilated certificate.

     Section 2.10.  Amendment and Waiver.  No amendment,  modification or waiver
shall be binding or  effective  with  respect to any  provision  of Section  2.1
through  Section  2.11 of these  Articles  of  Incorporation  without  the prior
written  consent of a Majority  in  Interest  of each of the Series A  Preferred
Stock,  Series B Preferred Stock or Series C Preferred Stock  outstanding at the
time such action is taken.

     Section 2.11.  Notices.  Except as otherwise  expressly provided hereunder,
all notices  referred to herein  shall be in writing and shall be  delivered  by
registered or certified mail, return receipt  requested and postage prepaid,  or
by reputable overnight courier or telecopy service,  charges prepaid,  and shall
be deemed to have been given when so mailed or sent (a) to the  Corporation,  at
its principal  executive  offices and (b) to any  stockholder,  at such holder's
address as it appears in the stock records of the Corporation  (unless otherwise
indicated by any such holder).

                                    ARTICLE V

                                Preemptive Rights

     The owners of shares of stock of the Corporation  shall not have preemptive
rights to  subscribe  for or purchase  any part of new or  additional  issues of
stock, or securities  convertible into stock, of any class  whatsoever,  whether
now or hereafter authorized, and whether issued for cash, property, services, by
way of dividends, or otherwise.





                                       14



                                   ARTICLE VI

                                Cumulative Voting

     Each shareholder  entitled to vote at any election for directors shall have
the right to vote, in person or by proxy,  the number of shares owned by him for
as many persons as there are  directors to be elected and for those  election he
has a right to vote, and no shareholder shall be entitled to cumulate his votes.

                                   ARTICLE VII

                       Limitation of Directors' Liability

     A director shall have no liability to the  Corporation or its  shareholders
for monetary damages for conduct as a director, except for (a) any breach of the
director's duty of loyalty to the Corporation or its  shareholders;  (b) acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law by the director;  (c) conduct  violating ORS 60.367; or (d) any
transaction from which the director derives an improper personal benefit. If the
Oregon  Business  Corporation  Act is hereafter  amended to authorize  corporate
action further eliminating or limiting the personal liability of directors, then
the  liability of a director  shall be  eliminated or limited to the full extent
permitted by the Oregon Business  Corporation  Act as so amended.  Any repeal or
modification of this Article shall not adversely  affect any right or protection
of a director  that exists at the time of such repeal or  modification  and that
extends to an act or omission of such director occurring prior to such repeal or
modification.

                                  ARTICLE VIII

                          Bylaws; Amendment of Articles

     Section 1. Bylaws.  The board of directors  shall have full power to adopt,
alter, amend or repeal the Bylaws or adopt new Bylaws. Nothing herein shall deny
the concurrent  power of the shareholders to adopt,  alter,  amend or repeal the
Bylaws.

     Section 2.  Amendment of Articles.  The  Corporation  reserves the right to
amend,  alter,  change or repeal any  provisions  contained  in its  Articles of
Incorporation in any manner now or hereafter prescribed or permitted by statute.
All  rights of  shareholders  of the  Corporation  are  granted  subject to this
reservation.

                                   ARTICLE IX

                           Registered Office and Agent

     The address of the  registered  office of the  Corporation is 601 SW Second
Avenue, Suite 2050, Portland, Oregon 97204, and the name of the registered agent
at such address is CT Corporation  System.  The registered office and registered
agent of the Corporation




                                       15



may be  changed  from  time to time by the  Board  of  Directors  but may not be
located outside of the State of Oregon.

                                    ARTICLE X

                                    Directors

     Section 1. Number of Directors. The Board of Directors shall consist of not
less  than six nor more than  eleven,  the  exact  number to be set as  provided
herein.  Until increased or decreased as provided herein, the Board of Directors
shall consist of eight members. The Board of Directors is authorized to increase
or  decrease  the size of the Board of  Directors  (within  the range  specified
above) at any time by the  affirmative  vote of two-thirds of the directors then
in office.  Without the unanimous  consent of the directors  then in office,  no
more than two additional  directors  shall be added to the Board of Directors in
any 12-month  period.  Without the unanimous  approval of the directors  then in
office, no person who is affiliated as an owner, director,  officer, employee or
consultant  of a company  or  business  deemed by the Board of  Directors  to be
competitive with that of the Corporation shall be eligible to serve of the Board
of Directors of the Corporation.

     Section 2. Classified Board.

     The Board shall be divided into three classes: Class I Directors,  Class II
Directors and Class III Directors.  Each such class of directors shall be nearly
equal in number of directors as possible.  Each director  shall serve for a term
ending at the third annual shareholders' meeting following the annual meeting at
which such director was elected;  provided,  however,  that the directors  first
elected as Class I Directors shall serve for a term ending at the annual meeting
to be held in the year following the first election of directors by classes, the
directors  first elected as Class II Directors  shall serve for a term ending at
the annual meeting to be held in the second year following the first election of
directors  by classes and the  directors  first  elected as Class III  directors
shall serve for a term ending at the annual meeting to be held in the third year
following  the first  election  of  directors  by classes.  Notwithstanding  the
foregoing,  each director shall serve until his or her successor shall have been
elected and qualified or until his or her earlier death, resignation or removal.

     At each annual election,  the directors chosen to succeed those whose terms
then expire shall be identified as being of the same class as the directors they
succeed,  unless, by reason of any intervening  changes in the authorized number
of directors,  the Board shall  designate one or more  directorships  whose term
then expire as  directorships  of another  class in order more nearly to achieve
equality in the number of directors  among the  classes.  When the Board fills a
vacancy  resulting  from the death,  resignation  or removal of a director,  the
director  chosen to fill that vacancy shall be of the same class as the director
he or she succeeds,  unless, by reason of any previous changes in the authorized
number of  directors,  the Board shall  designate the vacant  directorship  as a
directorship  of another  class in order more nearly to achieve  equality in the
number of




                                       16



directors among the classes.  The terms of any director  elected by the Board to
fill a vacancy will expire at the next  shareholders  meeting at which directors
are elected, despite the class such director has been elected to fill.

     Notwithstanding the rule that the three classes shall be as nearly equal in
number of  directors as possible,  upon any change in the  authorized  number of
directors,  each  director then  continuing  to serve as such will  nevertheless
continue  as a director  of the class of which he or she is a member,  until the
expiration of his or her current term or his or her earlier  death,  resignation
or removal.

     Newly created  directorships  resulting  from any increase in the number of
directors  and any  vacancies  on the Board of Directors  resulting  from death,
resignation, removal or other cause shall be filled by the affirmative vote of a
majority  of the  remaining  directors  then in office,  even though less than a
quorum  of the Board of  Directors.  No  decrease  in the  number  of  directors
constituting  the Board of  Directors  shall  shorten the term of any  incumbent
director.

     Section 3. Initial Directors as Classified.

     The directors of the Corporation  first elected to classes are eight (8) in
number and their names and class are:

Name                                   Class
- ----                                   -----

James C. O'Shea                         III
John Ruedy, MD                          III
William A. Gouveia                        I
Grace Keeney Fey                         II
Eric T. Herfindal                        II
Richard Plestina                         II
David H. DeWeese                          I
Michael T. Sember                       III


     Section 4. Removal of Directors.

     Directors  may be removed only for cause.  For purposes of this  Amendment,
"cause"  shall mean that the  director  has:  (i)  committed  an act of fraud or
embezzlement  against the  Corporation;  (ii) been  convicted  of, or plead nolo
contendre  to a crime  involving  moral  turpitude;  (iii) failed to perform the
director's  duties as a director  and such failure  constitutes  a breach of the
director's duty of loyalty to the  Corporation or provides an improper  personal
benefit to the director.




                                       17



                                   ARTICLE XI

                                  Incorporator

     The name and address of the incorporator are:

         Name                               Address
         ----                               -------
         Benjamin F. Stephens               c/o Bogle & Gates
                                            Two Union Square
                                            601 Union Street
                                            Seattle, Washington  98101-2346


                                   ARTICLE XII

                     Shareholder Approval Of Certain Events

     Notwithstanding any provision of Articles of Incorporation,  as amended, or
Bylaws  of the  Corporation,  and  notwithstanding  the fact  that  some  lesser
percentage may be allowed by law, any amendment,  change or repeal of Articles X
or XII, or any other  amendment  of the Articles of  Incorporation,  as amended,
which would have the effect of  modifying  or  permitting  circumvention  of the
provisions of Articles X or XII, shall require the following  shareholder votes:
(i) the  affirmative  votes  of 75  percent  of all  outstanding  shares  of the
Corporation  entitled to vote on the matter,  voting together as a single class;
and (ii) if any shares of the  Corporation are entitled to vote on the matter as
a separate  group,  the  affirmative  vote of 75 percent of such shares,  voting
separately.


DATED:   October 11, 1999.

                                         /s/ James C. O'Shea
                                         --------------------------------------