1 January 5, 1998 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, DC 20549 Ladies and Gentlemen: We have read Item 4 of Bio-Plexus' Form 8-K dated January 5, 1998 and are in agreement with the statements contained in the first, second and third paragraphs therein. Yours very truly, J. Timothy Reilly Price Waterhouse LLP